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Jean-Pierre Hénichart

Research Profile

Concepts & Ideas

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

Disorders

Prostatic Neoplasms

Procedures

Phenomena

Circular Dichroism

Genes & Molecular Sequences

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Alina Ghinet; Jean-Pierre Hénichart; Delphine Le Broc-Ryckewaert; Jean Pommery; Nicole Pommery; Bruno Quesnel; Benoît Rigo; Xavier Thuru; Philippe Gautret
Synthesis and biological evaluation of phenstatin metabolites.
Delphine Le Broc-Ryckewaert; Jean Pommery; Nicole Pommery; Benoît Rigo; Jean-François Wiart; Amaury Farce; Philippe Gautret; Alina Ghinet; Jean-Pierre Hénichart
In vitro metabolism of phenstatin: potential pharmacological consequences.
Nicolas Wlodarczyk; Delphine Le Broc-Ryckewaert; Pauline Gilleron; Amélie Lemoine; Amaury Farce; Philippe CHAVATTE; Joëlle Dubois; Nicole Pommery; Jean-Pierre Hénichart; Christophe Furman; Régis Millet
Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

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2011: Alina Ghinet; Jean-Pierre Hénichart; Delphine Le Broc-Ryckewaert; Jean Pommery; Nicole Pommery; Bruno Quesnel; Benoît Rigo; Xavier Thuru; Philippe Gautret
Synthesis and biological evaluation of phenstatin metabolites.
Bioorganic & medicinal chemistry 2011;19(20):6042-54.
2011: Delphine Le Broc-Ryckewaert; Jean Pommery; Nicole Pommery; Benoît Rigo; Jean-François Wiart; Amaury Farce; Philippe Gautret; Alina Ghinet; Jean-Pierre Hénichart
In vitro metabolism of phenstatin: potential pharmacological consequences.
Drug metabolism letters 2011;5(3):209-15.
2011: Nicolas Wlodarczyk; Delphine Le Broc-Ryckewaert; Pauline Gilleron; Amélie Lemoine; Amaury Farce; Philippe CHAVATTE; Joëlle Dubois; Nicole Pommery; Jean-Pierre Hénichart; Christophe Furman; Régis Millet
Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.
Journal of medicinal chemistry 2011;54(5):1178-90.
2009: Jamal El Bakali; Frédérique Klupsch; Aurore Guédin; Bertrand BRASSART; Gaëlle Fontaine; Amaury Farce; Pascal Roussel; Raymond Houssin; Jean-Luc Bernier; Philippe CHAVATTE; Jean-Louis Mergny; Jean-François Riou; Jean-Pierre Hénichart
2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
Bioorganic & medicinal chemistry letters 2009;19(13):3434-8.
2009: Anne Thiry; Aurélie Delayen; Laurence Goossens; Raymond Houssin; Marie Ledecq; Aurélie Frankart; Jean-Michel Dogné; Johan Wouters; Claudiu T Supuran; Jean-Pierre Hénichart; Bernard Masereel
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors.
European journal of medicinal chemistry 2009;44(2):511-8.
2008: Nicolas Bézière; Laurence Goossens; Jean Pommery; Hervé Vezin; Nadia Touati; Jean-Pierre Hénichart; Nicole Pommery
New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.
Bioorganic & medicinal chemistry letters 2008;18(16):4655-7.
2008: Adina Ryckebusch; Deborah Garcin; Amélie Lansiaux; Jean-François Goossens; Brigitte Baldeyrou; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.
Journal of medicinal chemistry 2008;51(12):3617-29.
2008: Fabrice Bailly; Clémence Queffélec; Gladys Mbemba; Jean-François Mouscadet; Nicole Pommery; Jean Pommery; Jean-Pierre Hénichart; Philippe Cotelle
Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
European journal of medicinal chemistry 2008;43(6):1222-9.
2007: Eric Stern; Giulio G Muccioli; Barbara Bosier; Laurie Hamtiaux; Régis Millet; Jacques H Poupaert; Jean-Pierre Hénichart; Patrick Depreux; Jean-François Goossens; Didier M Lambert
Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.
Journal of medicinal chemistry 2007;50(22):5471-84.
2007: Pauline Gilleron; Nicolas Wlodarczyk; Raymond Houssin; Amaury Farce; Guillaume Laconde; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Jean-Pierre Hénichart; Régis Millet
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(19):5465-71.
2007: Aurélie Telliez; Matthieu Desroses; Nicole Pommery; Olivier Briand; Amaury Farce; Guillaume Laconde; Amélie Lemoine; Patrick Depreux; Jean-Pierre Hénichart
Derivatives of Iressa, a specific epidermal growth factor receptor inhibitor, are powerful apoptosis inducers in PC3 prostatic cancer cells.
ChemMedChem 2007;2(3):318-32.
2007: Laurence Goossens; Nicole Pommery; Jean-Pierre Hénichart
COX-2/5-LOX dual acting anti-inflammatory drugs in cancer chemotherapy.
Current topics in medicinal chemistry 2007;7(3):283-96.
2006: Frédérique Klupsch; Raymond Houssin; Luc Humbert; Michel Imbenotte; Jean-Pierre Hénichart; Michel Lhermitte
Major metabolites of zolpidem: expeditious synthesis and mass spectra.
Chemical & pharmaceutical bulletin 2006;54(9):1318-21.
2006: Pauline Gilleron; Régis Millet; Raymond Houssin; Nicolas Wlodarczyk; Amaury Farce; Amélie Lemoine; Jean-François Goossens; Philippe CHAVATTE; Nicole Pommery; Jean-Pierre Hénichart
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.
European journal of medicinal chemistry 2006;41(6):745-55.
2006: Aurélie Telliez; Christophe Furman; Nicole Pommery; Jean-Pierre Hénichart
Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity.
Anti-cancer agents in medicinal chemistry 2006;6(3):187-208.
2006: Jean-Pierre Hénichart
Cyclooxygenase-2 inhibitors and cancer.
Anti-cancer agents in medicinal chemistry 2006;6(3):185.
2006: Murielle Mimeault; Erik Moore; Nicolas Moniaux; Jean-Pierre Hénichart; Patrick Depreux; Ming-Fong Lin; Surinder Batra
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells.
International journal of cancer. Journal international du cancer 2006;118(4):1022-31.
2006: Caroline Charlier; Aurelie Delayen; Bernadette Norberg; Jean-Pierre Hénichart; Johan Wouters
(2RS,5SR,6SR)-methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 2):o92-4.
2006: Pauline Gilleron; Régis Millet; Juozas Domarkas; Amaury Farce; Raymond Houssin; Jean-Pierre Hénichart
Synthesis of a novel conformationally restricted Val-Phe dipeptidomimetic.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(2):140-6.
2006: Caroline Charlier; Jean-Pierre Hénichart; François Durant; Johan Wouters
Structural insights into human 5-lipoxygenase inhibition: combined ligand-based and target-based approach.
Journal of medicinal chemistry 2006;49(1):186-95.
2006: Eric Stern; Giulio G Muccioli; Régis Millet; Jean-François Goossens; Amaury Farce; Philippe CHAVATTE; Jacques H Poupaert; Didier M Lambert; Patrick Depreux; Jean-Pierre Hénichart
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.
Journal of medicinal chemistry 2006;49(1):70-9.
2005: Nicole Pommery; Jean-Pierre Hénichart
Involvement of PI3K/Akt pathway in prostate cancer--potential strategies for developing targeted therapies.
Mini reviews in medicinal chemistry 2005;5(12):1125-32.
2005: Jean Pommery; Nicole Pommery; Jean-Pierre Hénichart
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
Prostaglandins, leukotrienes, and essential fatty acids 2005;73(6):411-7.
2005: Adina Ryckebusch; Pauline Gilleron; Régis Millet; Raymond Houssin; Amélie Lemoine; Nicole Pommery; Philippe Grellier; Christian Sergheraert; Jean-Pierre Hénichart
Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.
Chemical & pharmaceutical bulletin 2005;53(10):1324-6.
2005: Bruno Fuks; Patrice Talaga; Catherine Huart; Jean-Pierre Hénichart; Karine Bertrand; Renee Grimée; Geneviève Lorent
In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor.
European journal of pharmacology 2005;519(1-2):24-30.
2005: Laurence Goossens; Sophie Duban-Deweer; Jean Pommery; Jean-Pierre Hénichart; Jean-François Goossens
Spectroscopic study of fluorescent peptides for prenyl transferase assays.
Journal of pharmaceutical and biomedical analysis 2005;37(3):417-22.
2005: Guillaume Laconde; Patrick Depreux; Pascal Berthelot; Nicole Pommery; Jean-Pierre Hénichart
New antiproliferative benzoindolinothiazepines derivatives.
European journal of medicinal chemistry 2005;40(2):167-72.
2005: Murielle Mimeault; Nathalie Jouy; Patrick Depreux; Jean-Pierre Hénichart
Synergistic antiproliferative and apoptotic effects induced by mixed epidermal growth factor receptor inhibitor ZD1839 and nitric oxide donor in human prostatic cancer cell lines.
The Prostate 2005;62(2):187-99.
2005: Nicolas Wlodarczyk; Pauline Gilleron; Régis Millet; Raymond Houssin; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Ming X Wei; Jean-Pierre Hénichart
In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines.
Oncology research 2005;16(3):107-18.
2005: Nicole Pommery; Jean-Pierre Hénichart
[Involvement of PI3K/Akt pathway in prostate cancer. Potential strategies for developing targeted therapies].
Annales pharmaceutiques françaises 2005;63(1):69-75.
2004: Régis Millet; Juozas Domarkas; Raymond Houssin; Pauline Gilleron; Jean-François Goossens; Philippe CHAVATTE; Cédric Logé; Nicole Pommery; Jean Pommery; Jean-Pierre Hénichart
Potent and selective farnesyl transferase inhibitors.
Journal of medicinal chemistry 2004;47(27):6812-20.
2004: Nicole Pommery; Thierry Taverne; Aurélie Telliez; Laurence Goossens; Caroline Charlier; Jean Pommery; Jean-François Goossens; Raymond Houssin; François Durant; Jean-Pierre Hénichart
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Journal of medicinal chemistry 2004;47(25):6195-206.
2004: Caroline Charlier; Bernadette Norberg; Laurence Goossens; Jean-Pierre Hénichart; François Durant
1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 9):o648-52.
2004: Sarah Catoen-Chackal; Michaël Facompré; Raymond Houssin; Nicole Pommery; Jean-François Goossens; Pierre Colson; Christian Bailly; Jean-Pierre Hénichart
DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal of medicinal chemistry 2004;47(14):3665-73.
2004: Aurore Perzyna; Frédérique Klupsch; Raymond Houssin; Nicole Pommery; Amélie Lemoine; Jean-Pierre Hénichart
New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2004;14(9):2363-5.
2004: Frédéric Delbecq; Guy Cordonnier; Nicole Pommery; Didier Barbry; Jean-Pierre Hénichart
New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(5):1119-21.
2004: Natacha Malecki; Pascal Carato; Benoît Rigo; Jean-François Goossens; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis of condensed quinolines and quinazolines as DNA ligands.
Bioorganic & medicinal chemistry 2004;12(3):641-7.
2003: Murielle Mimeault; Nicole Pommery; Jean-Pierre Hénichart
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
International journal of cancer. Journal international du cancer 2003;106(1):116-24.
2003: Murielle Mimeault; Nicole Pommery; Nicole Wattez; Christian Bailly; Jean-Pierre Hénichart
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
The Prostate 2003;56(1):1-12.
2003: Aurore Perzyna; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Carine Marty; Michaël Facompré; Pierre Colson; Claude Houssier; Christian Bailly; Jean-Pierre Hénichart
Indolizino[1,2-b]quinolines derived from A-D rings of camptothecin: synthesis and DNA interaction.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):101-9.
2003: Guillaume Laconde; Nicole Pommery; Patrick Depreux; P Berthelot; Jean-Pierre Hénichart
New analogues of the anticancer E7070: synthesis and pharmacology.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):89-94.
2003: Sarah Chackal; Michaël Facompré; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Jean-Pierre Hénichart; Christian Bailly
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.
Bioorganic & medicinal chemistry letters 2003;13(5):943-6.
2003: Murielle Mimeault; Nicole Pommery; Jean-Pierre Hénichart
New advances on prostate carcinogenesis and therapies: involvement of EGF-EGFR transduction system.
Growth factors (Chur, Switzerland) 2003;21(1):1-14.
2003: Christophe Genicot; Bernard Christophe; Philippe Collart; Michel Gillard; Laurence Goossens; Jean-Pierre Hénichart; Marie-Agnès Lassoie; F Moureau; M Neuwels; Jean-Marie Nicolas; Patrick Pasau; Luc Quéré; Thomas Ryckmans; F Stiernet; Thierry Taverne; BerendJan van Keulen
Discovery of orally bioavailable NK1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):437-42.
2002: Aurore Perzyna; Carine Marty; Michaël Facompré; Jean-François Goossens; Nicole Pommery; Pierre Colson; Claude Houssier; Raymond Houssin; Jean-Pierre Hénichart; Christian Bailly
Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Journal of medicinal chemistry 2002;45(26):5809-12.
2002: Bertrand Le Bourdonnec; Christine Cauvin; Emmanuelle Meulon; Saïd Yous; Jean-François Goossens; François Durant; Raymond Houssin; Jean-Pierre Hénichart
Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.
Journal of medicinal chemistry 2002;45(21):4794-8.
2002: Régis Millet; Juozas Domarkas; Benoît Rigo; Laurence Goossens; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.
Bioorganic & medicinal chemistry 2002;10(9):2905-12.
2002: Axel Couture; Pierre Grandclaudon; Christophe Hoarau; Joséphine Cornet; Jean-Pierre Hénichart; Raymond Houssin
Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.
The Journal of organic chemistry 2002;67(11):3601-6.
2002: Sarah Chackal; Raymond Houssin; Jean-Pierre Hénichart
An efficient synthesis of the new benzo[c]pyrido[2,3,4-kl]acridine skeleton.
The Journal of organic chemistry 2002;67(10):3502-5.
2002: Sabine Barbey; Laurence Goossens; Thierry Taverne; Joséphine Cornet; Valérie Choesmel; Céline Rouaud; Gilles Gimeno; Sylvie Yannic-Arnoult; Catherine Michaux; Caroline Charlier; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Bioorganic & medicinal chemistry letters 2002;12(5):779-82.
2002: Raymond Houssin; Jean Pommery; Marie-Catherine Salaün; Sophie Duban-Deweer; Jean-François Goossens; Philippe CHAVATTE; Jean-Pierre Hénichart
Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.
Journal of medicinal chemistry 2002;45(2):533-6.
2001: C Cauvin; Bertrand Le Bourdonnec; Bernadette Norberg; Jean-Pierre Hénichart; François Durant
Pyrazolidine-3,5-dione angiotensin-II receptor antagonists.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 11):1330-2.
2001: Philippe CHAVATTE; Saïd Yous; Daniel Lesieur; Jean-Pierre Hénichart
Conformational analysis of tripeptide Ac-Lys-Pro-Val-NH2, COOH-terminal sequence of alpha-MSH.
The Journal of pharmacy and pharmacology 2001;53(7):949-53.
2001: Régis Millet; Laurence Goossens; K Bertrand-Caumont; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
A flexible approach to the design of new potent substance P receptor ligands.
The Journal of pharmacy and pharmacology 2001;53(7):929-34.
2001: Régis Millet; Laurence Goossens; Jean-François Goossens; Philippe CHAVATTE; K Bertrand-Caumont; Raymond Houssin; Jean-Pierre Hénichart
Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(6):323-30.
2001: Jean-François Goossens; E Bouey-Bencteux; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; William Laine; Brigitte Baldeyrou; Christian Bailly
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Biochemistry 2001;40(15):4663-71.
2001: C Audouin; N Mestdagh; Marie-Agnès Lassoie; Raymond Houssin; Jean-Pierre Hénichart
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 2001;11(6):845-8.
2001: R Dupont; Jean-François Goossens; Nicole Cotelle; L Vrielynck; Hervé Vezin; Jean-Pierre Hénichart; Philippe Cotelle
New bis-catechols 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry 2001;9(2):229-35.
2000: Bertrand Le Bourdonnec; E Meulon; Saïd Yous; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists.
Journal of medicinal chemistry 2000;43(14):2685-97.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Laurent Dassonneville; Michaël Facompré; Christian Bailly
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(2):125-31.
2000: F Dudouit; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; N Gelus; Christian Bailly
Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.
Bioorganic & medicinal chemistry letters 2000;10(6):553-7.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Fabrice Anizon; Michelle Prudhomme; C Dugave; J Riou; Christian Bailly
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
European journal of pharmacology 2000;389(2-3):141-6.
1999: M O Catrycke; Raymond Houssin; Jean-Pierre Hénichart; B Pfeiffer; Pierre Renard; Laurent Dassonneville; Christian Bailly
Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.
Bioorganic & medicinal chemistry letters 1999;9(14):2025-30.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; D Sevère; Jean-François Riou; Jean-François Goossens; Jean-Pierre Hénichart; Christian Bailly; E Labourier; J Tazzi; Doriano Fabbro; T Meyer; AM Aubertin
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.
1999: F Leroux; BerendJan van Keulen; J Daliers; Nicole Pommery; Jean-Pierre Hénichart
Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives.
Bioorganic & medicinal chemistry 1999;7(3):509-16.
1998: E Bouey-Bencteux; C Loison; Nicole Pommery; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.
Anti-cancer drug design 1998;13(8):893-922.
1997: N Boitte; Nicole Pommery; P Colson; Claude Houssier; M J Waring; Jean-Pierre Hénichart; C Bailly
Synthesis, DNA-binding and cytotoxic properties of a bis(netropsin)-anthracenedione conjugate.
Anti-cancer drug design 1997;12(6):481-501.
1996: J F Goossens; P Cotelle; Philippe CHAVATTE; Jean-Pierre Hénichart
NMR study of five N-terminal peptide fragments of the vasoactive intestinal peptide: crucial role of aromatic residues.
Peptide research 1996;9(6):322-6.
1996: Nicole Helbecque; A el Idrissi Boutaher; Jean-Pierre Hénichart
Interaction with DNA of oligopeptides related to the Arc repressor.
Peptide research 1996;9(1):21-7.
1995: Bertrand Plouvier; Raymond Houssin; Nicole Helbecque; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Christian Bailly
Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.
Anti-cancer drug design 1995;10(2):155-66.
1995: C Bourdouxhe; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Michael J Waring; W A Denny; Christian Bailly
Design of composite drug molecules: mutual effects on binding to DNA of an intercalator, amsacrine, and a minor groove binder, netropsin.
Anti-cancer drug design 1995;10(2):131-54.
1994: Christian Bailly; C Michaux; Pierre Colson; Claude Houssier; Jian-Sheng Sun; Thérèse Garestier; Claude Hélène; Jean-Pierre Hénichart; C Rivalle; Emile Bisagni
Reaction of a biscationic distamycin-ellipticine hybrid ligand with DNA. Mode and sequence specificity of binding.
Biochemistry 1994;33(51):15348-64.
1994: V Galet; J L Bernier; Jean-Pierre Hénichart; Daniel Lesieur; C Abadie; L Rochette; A Lindenbaum; Jacqueline Chalas; J F Renaud de la Faverie; Bruno Pfeiffer
Benzoselenazolinone derivatives designed to be glutathione peroxidase mimetics feature inhibition of cyclooxygenase/5-lipoxygenase pathways and anti-inflammatory activity.
Journal of medicinal chemistry 1994;37(18):2903-11.
1994: Bertrand Plouvier; Raymond Houssin; B Hecquet; Pierre Colson; Claude Houssier; M J Waring; Jean-Pierre Hénichart; Christian Bailly
Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.
Bioconjugate chemistry 1994;5(5):475-81.
1994: P Fossé; Brigitte RENE; JM Saucier; Jean-Pierre Hénichart; M J Waring; P Colson; C Houssier; C Bailly
Stimulation of site-specific topoisomerase II-mediated DNA cleavage by an N-methylpyrrolecarboxamide-anilinoacridine conjugate: relation to DNA binding.
Biochemistry 1994;33(33):9865-74.
1994: N Mestdagh; B Vandewalle; Louis Hornez; Jean-Pierre Hénichart
Comparative study of intracellular calcium and adenosine 3',5'-cyclic monophosphate levels in human breast carcinoma cells sensitive or resistant to Adriamycin: contribution to reversion of chemoresistance.
Biochemical pharmacology 1994;48(4):709-16.
1994: F Leroux; J F Goossens; Nicole Pommery; Jean-Pierre Hénichart
A new vasoactive intestinal peptide antagonist discriminates VIP receptors on guinea pig trachea and human neuroblastoma cells.
Regulatory peptides 1994;52(2):119-28.
1994: J F Goossens; F Leroux; Nicole Pommery; J Pommery; Jean-Pierre Hénichart
High-performance liquid chromatographic determination of cyclic 3',5'-AMP with fluorescence detection. Vasoactive intestinal peptide-induced modification of its concentration in neuroblastoma cells.
Journal of chromatography. B, Biomedical applications 1994;657(1):192-6.
1994: K E Rao; Gilles Gosselin; D Mrani; Christian Périgaud; Jean-Louis Imbach; Christian Bailly; Jean-Pierre Hénichart; P Colson; Claude Houssier; J W Lown
Psoralen--lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease III stop assay, and mode of binding from electric linear dichroism.
Anti-cancer drug design 1994;9(3):221-37.
1994: N Mestdagh; Nicole Pommery; J M Saucier; B Hecquet; C Fournier; C Slomianny; E Teissier; Jean-Pierre Hénichart
Chemoresistance to doxorubicin and cisplatin in a murine cell line. Analysis of P-glycoprotein, topoisomerase II activity, glutathione and related enzymes.
Anticancer research 1994;14(3A):869-74.
1994: A Kénani; C Bailly; Raymond Houssin; Jean-Pierre Hénichart
Comparative subcellular distribution of the copper complexes of bleomycin-A2 and deglycobleomycin-A2.
Anti-cancer drugs 1994;5(2):199-201.
1994: S Flock; F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier
Interaction of two peptide-acridine conjugates containing the SPKK peptide motif with DNA and chromatin.
Journal of biomolecular structure & dynamics 1994;11(4):881-900.
1993: N Mestdagh; E Morier-Teissier; Jean-Pierre Hénichart
Effect of various chemosensitizers on chemoresistance to adriamycin in MIP-101 cell line, a colon carcinoma cell line: analysis of glutathione and related enzymes.
Anti-cancer drugs 1993;4(6):641-50.
1993: E Morier-Teissier; N Boitte; Nicole Helbecque; Jean-Luc Bernier; Nicole Pommery; J L Duvalet; C Fournier; B Hecquet; Jean Pierre Catteau; Jean-Pierre Hénichart
Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His.
Journal of medicinal chemistry 1993;36(15):2084-90.
1993: F Bailly; Christian Bailly; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
A tandem repeat of the SPKK peptide motif induces psi-type DNA structures at alternating AT sequences.
FEBS letters 1993;324(2):181-4.
1993: Christian Bailly; V Leclere; Nicole Pommery; Pierre Colson; Claude Houssier; C Rivalle; Emile Bisagni; Jean-Pierre Hénichart
Binding to DNA, cellular uptake and biological activity of a distamycin-ellipticine hybrid molecule.
Anti-cancer drug design 1993;8(2):145-64.
1993: J F Goossens; D Manechez; Nicole Pommery; P Formstecher; Jean-Pierre Hénichart
VIP potentiates retinoic-acid effect on tissue transglutaminase activity in human neuroblastoma, the SK-N-SH cells.
Neuropeptides 1993;24(2):99-103.
1992: C Bourdouxhe; Pierre Colson; Claude Houssier; Jian-Sheng Sun; T Montenay-Garestier; Claude Hélène; C Rivalle; Emile Bisagni; Michael J Waring; Jean-Pierre Hénichart
Binding of a distamycin-ellipticine hybrid molecule to DNA and chromatin: spectroscopic, biochemical, and molecular modeling investigations.
Biochemistry 1992;31(49):12385-96.
1992: Christian Bailly; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier
Drug-DNA sequence-dependent interactions analysed by electric linear dichroism.
Journal of molecular recognition : JMR 1992;5(4):155-71.
1992: Christian Bailly; P Colson; Claude Houssier; Raymond Houssin; D Mrani; Gilles Gosselin; Jean-Louis Imbach; M J Waring; J W Lown; Jean-Pierre Hénichart
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.
Biochemistry 1992;31(35):8349-62.
1992: N Cotelle; Jean-Luc Bernier; Jean-Pierre Hénichart; Jean Pierre Catteau; E Gaydou; J C Wallet
Scavenger and antioxidant properties of ten synthetic flavones.
Free radical biology & medicine 1992;13(3):211-9.
1992: F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart
Selective binding to AT sequences in DNA by an acridine-linked peptide containing the SPKK motif.
Biochemical and biophysical research communications 1992;184(2):930-7.
1992: N Mestdagh; J Poupaert; Jean-Pierre Hénichart; Joseph Vamecq
Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions.
Biochemical pharmacology 1992;43(7):1529-37.
1992: N Cotelle; E Trémolières; Jean-Luc Bernier; Jean Pierre Catteau; Jean-Pierre Hénichart
Redox chemistry of complexes of nickel(II) with some biologically important peptides in the presence of reduced oxygen species: an ESR study.
Journal of inorganic biochemistry 1992;46(1):7-15.
1992: C Bailly; J S Sun; P Colson; C Houssier; C Hélène; M J Waring; Jean-Pierre Hénichart
Design of a sequence-specific DNA-cleaving molecule which conjugates a copper-chelating peptide, a netropsin residue, and an acridine chromophore.
Bioconjugate chemistry 1992;3(2):100-3.
1992: C Bailly; M Collyn-d'Hooghe; Danièle Lantoine; C Fournier; B Hecquet; P Fosse; JM Saucier; P Colson; C Houssier; Jean-Pierre Hénichart
Biological activity and molecular interaction of a netropsin-acridine hybrid ligand with chromatin and topoisomerase II.
Biochemical pharmacology 1992;43(3):457-66.
1992: E Morier-Teissier; Jean-Luc Bernier; Dominique Coulaud; Jean-Pierre Hénichart; Etienne Delain
Electron microscopic observations of the effects of anthraquinone derivatives on plasmid DNA.
Journal of biomolecular structure & dynamics 1992;9(4):653-66.
1992: F Bailly; Christian Bailly; Nicole Helbecque; Nicole Pommery; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
Relationship between DNA-binding and biological activity of anilinoacridine derivatives containing the nucleic acid-binding unit SPKK.
Anti-cancer drug design 1992;7(1):83-100.
1991: Bertrand Plouvier; Christian Bailly; Raymond Houssin; K E Rao; W J Lown; Jean-Pierre Hénichart; M J Waring
DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.
Nucleic acids research 1991;19(21):5821-9.
1991: C Bailly; Jean-Pierre Hénichart
DNA recognition by intercalator-minor-groove binder hybrid molecules.
Bioconjugate chemistry 1991;2(6):379-93.
1991: F Hamy; Philippe Verwaerde; Nicole Helbecque; P Formstecher; Jean-Pierre Hénichart
Nuclear targeting of a viral-cointernalized protein by a short signal sequence from human retinoic acid receptors.
Bioconjugate chemistry 1991;2(5):375-8.
1991: N Cotelle; S Moreau; P Cotelle; Jean Pierre Catteau; Jean-Luc Bernier; Jean-Pierre Hénichart
Generation of free radicals by simple prenylated hydroquinone derivatives, natural antitumor agents from the marine urochordate Aplidium californicum.
Chemical research in toxicology 1991;4(3):300-5.
1991: R Mahdadi; A Kenani; Nicole Pommery; J Pommery; Jean-Pierre Hénichart; Michel Lhermitte
High-performance liquid chromatography assay of bleomycin in human plasma and rat hepatocytes in culture.
Cancer chemotherapy and pharmacology 1991;28(1):22-6.
1991: N Cotelle; S Moreau; Jean-Luc Bernier; Jean Pierre Catteau; Jean-Pierre Hénichart
Antioxidant properties of natural hydroquinones from the marine colonial tunicate Aplidium californicum.
Free radical biology & medicine 1991;11(1):63-8.
1990: Christian Bailly; C OhUigin; C Rivalle; Emile Bisagni; Jean-Pierre Hénichart; Michael J Waring
Sequence-selective binding of an ellipticine derivative to DNA.
Nucleic acids research 1990;18(21):6283-91.
1990: N Cotelle; M Lohez; P Cotelle; Jean-Pierre Hénichart
Conformational study of the threonine-rich C-terminal pentapeptide of peptide T.
Biochemical and biophysical research communications 1990;171(2):596-602.
1990: E Morier-Teissier; Jean-Luc Bernier; M Lohez; Jean Pierre Catteau; Jean-Pierre Hénichart
Free radical production and DNA cleavage by copper chelating peptide-anthraquinones.
Anti-cancer drug design 1990;5(3):291-305.
1990: M Imbert; B Laine; Nicole Helbecque; J P Mornon; Jean-Pierre Hénichart; Pierre-Eric Sautière
Conformational study of the chromosomal protein MC1 from the archaebacterium Methanosarcina barkeri.
Biochimica et biophysica acta 1990;1038(3):346-54.
1990: C Bailly; Jean-Pierre Hénichart
Subcellular distribution of a nitroxide spin-labeled netropsin-acridine hybrid in living KB cells: Electron Spin Resonance Study.
Biochemical and biophysical research communications 1990;167(2):798-806.
1990: Christian Bailly; Nicole Helbecque; Jean-Pierre Hénichart; P Colson; Claude Houssier; K E Rao; R G Shea; J W Lown
Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand.
Journal of molecular recognition : JMR 1990;3(1):26-35.
1990: Christian Bailly; J C Beauvillain; Jean-Luc Bernier; Jean-Pierre Hénichart
Plasma membrane perturbations of KB3 cells induced by the bleomycin-iron complex.
Cancer research 1990;50(2):385-92.
1989: E Morier-Teissier; Christian Bailly; Jean-Luc Bernier; Raymond Houssin; Nicole Helbecque; Jean Pierre Catteau; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
Synthesis, biological activity and DNA interaction of anilinoacridine and bithiazole peptide derivatives related to the anti-tumor drugs m-AMSA and bleomycin.
Anti-cancer drug design 1989;4(1):37-52.
1989: Christian Bailly; Jean Pierre Catteau; Jean-Pierre Hénichart; K Reszka; R G Shea; K Krowicki; J W Lown
Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies.
Biochemical pharmacology 1989;38(10):1625-30.
1989: Jean-Luc Bernier; M Lohez; Nicole Helbecque; Jean-Pierre Hénichart
Effect of combination of m-AMSA and doxorubicin on their redox properties and on DNA cleavage.
Chemico-biological interactions 1989;70(1-2):103-15.
1988: A Kénani; C Bailly; Nicole Helbecque; Jean Pierre Catteau; Raymond Houssin; Jean-Luc Bernier; Jean-Pierre Hénichart
The role of the gulose-mannose part of bleomycin in activation of iron-molecular oxygen complexes.
The Biochemical journal 1988;253(2):497-504.
1988: A Kenani; G Lamblin; Jean-Pierre Hénichart
A convenient method for the cleavage of the D-mannosyl-L-gulose disaccharide from bleomycin-A2.
Carbohydrate research 1988;177():81-9.
1988: Christian Bailly; A Kenani; Nicole Helbecque; Jean-Luc Bernier; Raymond Houssin; Jean-Pierre Hénichart
DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.
Biochemical and biophysical research communications 1988;152(2):695-702.
1987: Nicole Helbecque; Jean-Luc Bernier; Jean-Pierre Hénichart; Arlette Martinage; Pierre-Eric Sautière
Synthesis and conformation of the amino-terminal hexapeptide of histone H2B from gonads of the starfish Asterias rubens.
International journal of peptide and protein research 1987;30(5):689-94.
1987: C Bailly; Jean Pierre Catteau; Nicole Helbecque; Jean-Luc Bernier; Raymond Houssin; C Denis; Jean-Pierre Hénichart
Complexation of copper(II) by a peptide hybrid of bleomycin and amsacrine. Circular dichroism and electron spin resonance studies.
Journal of inorganic biochemistry 1987;31(3):211-20.
1987: A Kenani; M Lohez; Raymond Houssin; Nicole Helbecque; Jean-Luc Bernier; P Lemay; Jean-Pierre Hénichart
Chelating, DNA-binding and DNA-cleaving properties of a synthetic model for bleomycin.
Anti-cancer drug design 1987;2(1):47-59.
1987: C Bailly; Jean-Luc Bernier; Raymond Houssin; Nicole Helbecque; Jean-Pierre Hénichart
Design of two metal-chelating, DNA-binding models: molecular combinations of bleomycin and amsacrine anti-tumour drugs.
Anti-cancer drug design 1987;1(4):303-12.
1986: Jean-Luc Bernier; A Kenani; Raymond Houssin; Nicole Helbecque; M Lohez; B Hecquet; Jean-Pierre Hénichart
Molecular interaction between bleomycin and amsacrine in the presence of cupric ions.
Journal of inorganic biochemistry 1986;27(4):271-85.
1985: Jean-Pierre Hénichart; Jean-Luc Bernier; Nicole Helbecque; Raymond Houssin
Is the bithiazole moiety of bleomycin a classical intercalator?
Nucleic acids research 1985;13(18):6703-17.
1985: Jean-Pierre Hénichart; Jean-Luc Bernier; Raymond Houssin; M Lohez; A Kenani; Jean Pierre Catteau
Copper(II)- and iron(II)-complexes of methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR investigation.
Biochemical and biophysical research communications 1985;126(3):1036-41.
1985: Nicole Helbecque; Jean-Luc Bernier; Jean-Pierre Hénichart
Design of a new DNA-polyintercalating drug, a bisacridinyl peptidic analogue of Triostin A.
The Biochemical journal 1985;225(3):829-32.
1983: P Lemay; Jean-Luc Bernier; Jean-Pierre Hénichart; Jean Pierre Catteau
Subcellular distribution of nitroxide spin-labelled 9-aminoacridine in living KB cells.
Biochemical and biophysical research communications 1983;111(3):1074-81.
1982: Jean-Pierre Hénichart; Jean-Luc Bernier; Jean Pierre Catteau
Interaction of 4-(9-acridinylamino)aniline and derivatives with DNA. Influence of a lysylglycyl side chain on the binding parameters.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1982;363(8):835-41.
1980: Raymond Houssin; Jean-Pierre Hénichart; M Foulon; F Baert
Structure-neuromuscular blocking activity relationships of ketophosphonium salts.
Journal of pharmaceutical sciences 1980;69(8):888-91.