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Wim Hennink

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Hagenaars Niels; Verheul Rolf J; Mooren Imke; de Jong Pascal H J L F; Mastrobattista Enrico; Glansbeek Harrie L; Heldens Jacco G M; van den Bosch Han; Hennink Wim E; Jiskoot Wim
Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine.
Elgersma Ronald C; van Dijk Maarten; Dechesne Annemarie C; van Nostrum Cornelus F; Hennink Wim E; Rijkers Dirk T S; Liskamp Rob M J
Microwave-assisted click polymerization for the synthesis of Abeta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates.
Seyednejad Hajar; Vermonden Tina; Fedorovich Natalja E; van Eijk Roel; van Steenbergen Mies J; Dhert Wouter J A; van Nostrum Cornelus F; Hennink Wim E
Synthesis and characterization of hydroxyl-functionalized caprolactone copolymers and their effect on adhesion, proliferation, and differentiation of human mesenchymal stem cells.

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All Publications

2009: Hagenaars Niels; Verheul Rolf J; Mooren Imke; de Jong Pascal H J L F; Mastrobattista Enrico; Glansbeek Harrie L; Heldens Jacco G M; van den Bosch Han; Hennink Wim E; Jiskoot Wim
Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(2):126-33.
2009: Elgersma Ronald C; van Dijk Maarten; Dechesne Annemarie C; van Nostrum Cornelus F; Hennink Wim E; Rijkers Dirk T S; Liskamp Rob M J
Microwave-assisted click polymerization for the synthesis of Abeta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates.
Organic & biomolecular chemistry 2009;7(21):4517-25.
2009: Seyednejad Hajar; Vermonden Tina; Fedorovich Natalja E; van Eijk Roel; van Steenbergen Mies J; Dhert Wouter J A; van Nostrum Cornelus F; Hennink Wim E
Synthesis and characterization of hydroxyl-functionalized caprolactone copolymers and their effect on adhesion, proliferation, and differentiation of human mesenchymal stem cells.
Biomacromolecules 2009;10(11):3048-54.
2009: Tai Hongyun; Howard Daniel; Takae Seiji; Wang Wenxin; Vermonden Tina; Hennink Wim E; Stayton Patrick S; Hoffman Allan S; Endruweit Andreas; Alexander Cameron; Howdle Steven M; Shakesheff Kevin M
Photo-cross-linked hydrogels from thermoresponsive PEGMEMA-PPGMA-EGDMA copolymers containing multiple methacrylate groups: mechanical property, swelling, protein release, and cytotoxicity.
Biomacromolecules 2009;10(10):2895-903.
2009: van Hell Albert J; Crommelin Daan J A; Hennink Wim E; Mastrobattista Enrico
Stabilization of peptide vesicles by introducing inter-peptide disulfide bonds.
Pharmaceutical research 2009;26(9):2186-93.
2009: Rissmann Robert; Oudshoorn Marion H M; Hennink Wim E; Ponec Maria; Bouwstra Joke A
Skin barrier disruption by acetone: observations in a hairless mouse skin model.
Archives of dermatological research 2009;301(8):609-13.
2009: Oudshoorn Marion H M; Rissmann Robert; van der Coelen Dennis; Hennink Wim E; Ponec Maria; Bouwstra Joke A
Effect of synthetic vernix biofilms on barrier recovery of damaged mouse skin.
Experimental dermatology 2009;18(8):695-703.
2009: Ghassemi A H; van Steenbergen M J; Talsma H; van Nostrum C F; Jiskoot W; Crommelin D J A; Hennink W E
Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid).
Journal of controlled release : official journal of the Controlled Release Society 2009;138(1):57-63.
2009: Vente M A D; Nijsen J F W; de Roos R; van Steenbergen M J; Kaaijk C N J; Koster-Ammerlaan M J J; de Leege P F A; Hennink W E; van Het Schip A D; Krijger G C
Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radio-embolization: a validation study.
Biomedical microdevices 2009;11(4):763-72.
2009: Lukowiak Monika; Kosson Piotr; Hennink Wim E; Lipkowski Andrzej W
Synthesis and pharmacological properties of a new fluorescent opioid peptide analog.
Pharmacological reports : PR 2009;61(4):727-31.
2009: Lammers Twan; Subr Vladimir; Ulbrich Karel; Peschke Peter; Huber Peter E; Hennink Wim E; Storm Gert
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.
Biomaterials 2009;30(20):3466-75.
2009: de Graaf Albert J; Kooijman Marlous; Hennink Wim E; Mastrobattista Enrico
Nonnatural amino acids for site-specific protein conjugation.
Bioconjugate chemistry 2009;20(7):1281-95.
2009: Verheul Rolf J; Amidi Maryam; van Steenbergen Mies J; van Riet Elly; Jiskoot Wim; Hennink Wim E
Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans.
Biomaterials 2009;30(18):3129-35.
2009: Bult W; Seevinck P R; Krijger G C; Visser T; Kroon-Batenburg L M J; Bakker C J G; Hennink W E; van het Schip A D; Nijsen J F W
Microspheres with ultrahigh holmium content for radioablation of malignancies.
Pharmaceutical research 2009;26(6):1371-8.
2009: Wilschut K J; van der Aa M A E M; Oosting R S; Hennink W E; Koning G A; Crommelin D J A; Mastrobattista E
Fluorescence in situ hybridization to monitor the intracellular location and accessibility of plasmid DNA delivered by cationic polymer-based gene carriers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;72(2):391-6.
2009: Rissmann Robert; Oudshoorn Marion H M; Zwier Raphaël; Ponec Maria; Bouwstra Joke A; Hennink Wim E
Mimicking vernix caseosa--preparation and characterization of synthetic biofilms.
International journal of pharmaceutics 2009;372(1-2):59-65.
2009: De Geest Bruno G; De Koker Stefaan; Demeester Jo; De Smedt Stefaan C; Hennink Wim E
Pulsed in vitro release and in vivo behavior of exploding microcapsules.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(3):268-73.
2009: Tai Hongyun; Wang Wenxin; Vermonden Tina; Heath Felicity; Hennink Wim E; Alexander Cameron; Shakesheff Kevin M; Howdle Steven M
Thermoresponsive and photocrosslinkable PEGMEMA-PPGMA-EGDMA copolymers from a one-step ATRP synthesis.
Biomacromolecules 2009;10(4):822-8.
2009: Meng Fenghua; Hennink Wim E; Zhong Zhiyuan
Reduction-sensitive polymers and bioconjugates for biomedical applications.
Biomaterials 2009;30(12):2180-98.
2009: van den Berg Joost H; Nujien Bastiaan; Beijnen Jos H; Vincent Andrew; van Tinteren Harm; Kluge Jörn; Woerdeman Leonie A E; Hennink Wim E; Storm Gert; Schumacher Ton N; Haanen John B A G
Optimization of intradermal vaccination by DNA tattooing in human skin.
Human gene therapy 2009;20(3):181-9.
2009: Talelli Marina; Rijcken Cristianne J F; Lammers Twan; Seevinck Peter R; Storm Gert; van Nostrum Cornelus F; Hennink Wim E
Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery.
Langmuir : the ACS journal of surfaces and colloids 2009;25(4):2060-7.
2009: Oudshoorn Marion H M; Rissmann Robert; van der Coelen Dennis; Hennink Wim E; Ponec Maria; Bouwstra Joke A
Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery.
Experimental dermatology 2009;18(2):178-84.
2009: Chaisri Wasana; Hennink Wim E; Okonogi Siriporn
Preparation and characterization of cephalexin loaded PLGA microspheres.
Current drug delivery 2009;6(1):69-75.
2009: Fedorovich Natalja E; Oudshoorn Marion H; van Geemen Daphne; Hennink Wim E; Alblas Jacqueline; Dhert Wouter J A
The effect of photopolymerization on stem cells embedded in hydrogels.
Biomaterials 2009;30(3):344-53.
2008: Fretz Marjan M; Dolman M E Emmy M; Lacombe Marie; Prakash Jai; Nguyen Tri Q; Goldschmeding Roel; Pato Janos; Storm Gert; Hennink Wim E; Kok Robbert J
Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(3):200-7.
2008: Dolman M E M; Fretz M M; Segers G J W; Lacombe M; Prakash J; Storm G; Hennink W E; Kok R J
Renal targeting of kinase inhibitors.
International journal of pharmaceutics 2008;364(2):249-57.
2008: De Geest Bruno G; McShane Michael J; Demeester Jo; De Smedt Stefaan C; Hennink Wim E
Microcapsules ejecting nanosized species into the environment.
Journal of the American Chemical Society 2008;130(44):14480-2.
2008: van de Manakker Frank; Vermonden Tina; El Morabit Najim; van Nostrum Cornelus F; Hennink Wim E
Rheological behavior of self-assembling PEG-beta-cyclodextrin/PEG-cholesterol hydrogels.
Langmuir : the ACS journal of surfaces and colloids 2008;24(21):12559-67.
2008: van Dijk Maarten; Nollet Maria L; Weijers Pascal; Dechesne Annemarie C; van Nostrum Cornelus F; Hennink Wim E; Rijkers Dirk T S; Liskamp Rob M J
Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry.
Biomacromolecules 2008;9(10):2834-43.
2008: Rissmann Robert; Oudshoorn Marion H M; Kocks Elise; Hennink Wim E; Ponec Maria; Bouwstra Joke A
Lanolin-derived lipid mixtures mimic closely the lipid composition and organization of vernix caseosa lipids.
Biochimica et biophysica acta 2008;1778(10):2350-60.
2008: Van Tomme Sophie R; van Nostrum Cornelus F; Dijkstra Marjolein; De Smedt Stefaan C; Hennink Wim E
Effect of particle size and charge on the network properties of microsphere-based hydrogels.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):522-30.
2008: Lammers T; Subr V; Peschke P; Kühnlein R; Hennink W E; Ulbrich K; Kiessling F; Heilmann M; Debus J; Huber P E; Storm G
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
British journal of cancer 2008;99(6):900-10.
2008: Hofman Jan-Willem; Carstens Myrra G; van Zeeland Femke; Helwig Conny; Flesch Frits M; Hennink Wim E; van Nostrum Cornelus F
Photocytotoxicity of mTHPC (temoporfin) loaded polymeric micelles mediated by lipase catalyzed degradation.
Pharmaceutical research 2008;25(9):2065-73.
2008: Verheul Rolf J; Amidi Maryam; van der Wal Steffen; van Riet Elly; Jiskoot Wim; Hennink Wim E
Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan.
Biomaterials 2008;29(27):3642-9.
2008: Piest Martin; Lin Chao; Mateos-Timoneda Miguel A; Lok Martin C; Hennink Wim E; Feijen Jan; Engbersen Johan F J
Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties.
Journal of controlled release : official journal of the Controlled Release Society 2008;130(1):38-45.
2008: de Wolf Holger K; Johansson Nina; Thong Anh-Thy; Snel Cor J; Mastrobattista Enrico; Hennink Wim E; Storm Gert
Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes.
Pharmaceutical research 2008;25(7):1654-62.
2008: Amidi Maryam; Krudys Kevin M; Snel Cor J; Crommelin Daan J A; Della Pasqua Oscar E; Hennink Wim E; Jiskoot Wim
Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(3):257-66.
2008: Van Tomme Sophie R; Storm Gert; Hennink Wim E
In situ gelling hydrogels for pharmaceutical and biomedical applications.
International journal of pharmaceutics 2008;355(1-2):1-18.
2008: Romberg Birgit; Flesch Frits M; Hennink Wim E; Storm Gert
Enzyme-induced shedding of a poly(amino acid)-coating triggers contents release from dioleoyl phosphatidylethanolamine liposomes.
International journal of pharmaceutics 2008;355(1-2):108-13.
2008: Vermonden Tina; Fedorovich Natalja E; van Geemen Daphne; Alblas Jacqueline; van Nostrum Cornelus F; Dhert Wouter J A; Hennink Wim E
Photopolymerized thermosensitive hydrogels: synthesis, degradation, and cytocompatibility.
Biomacromolecules 2008;9(3):919-26.
2008: Luten J; van Steenbergen M J; Lok M C; de Graaff A M; van Nostrum C F; Talsma H; Hennink W E
Degradable PEG-folate coated poly(DMAEA-co-BA)phosphazene-based polyplexes exhibit receptor-specific gene expression.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(3):241-51.
2008: Luten Jordy; van Nostrum Cornelus F; De Smedt Stefaan C; Hennink Wim E
Biodegradable polymers as non-viral carriers for plasmid DNA delivery.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(2):97-110.
2008: de Wolf Holger K; Luten Jordy; Snel Cor J; Storm Gert; Hennink Wim E
Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice.
Molecular pharmaceutics 2008;5(2):349-57.
2008: Lin Chao; Blaauboer Cees-Jan; Timoneda Miguel Mateos; Lok Martin C; van Steenbergen Mies; Hennink Wim E; Zhong Zhiyuan; Feijen Jan; Engbersen Johan F J
Bioreducible poly(amido amine)s with oligoamine side chains: synthesis, characterization, and structural effects on gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(2):166-74.
2008: Mateos-Timoneda Miguel A; Lok Martin C; Hennink Wim E; Feijen Jan; Engbersen Johan F J
Poly(amido amine)s as gene delivery vectors: effects of quaternary nicotinamide moieties in the side chains.
ChemMedChem 2008;3(3):478-86.
2008: Carstens Myrra G; de Jong Pascal H J L F; van Nostrum Cornelus F; Kemmink Johan; Verrijk Ruud; de Leede Leo G J; Crommelin Daan J A; Hennink Wim E
The effect of core composition in biodegradable oligomeric micelles as taxane formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(3):596-606.
2008: Rissmann Robert; Groenink Hendrik W W; Gooris Gert S; Oudshoorn Marion H M; Hennink Wim E; Ponec Maria; Bouwstra Joke A
Temperature-induced changes in structural and physicochemical properties of vernix caseosa.
The Journal of investigative dermatology 2008;128(2):292-9.
2008: Amidi Maryam; Pellikaan Hubert C; de Boer Anne H; Crommelin Daan J A; Hennink Wim E; Jiskoot Wim
Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):191-200.
2008: Ramzi Aissa; Rijcken Cristianne J F; Veldhuis Theo F J; Schwahn Dietmar; Hennink Wim E; van Nostrum Cornelus F
Core-shell structure of degradable, thermosensitive polymeric micelles studied by small-angle neutron scattering.
The journal of physical chemistry. B 2008;112(3):784-92.
2008: De Geest Bruno G; Van Camp Wim; Du Prez Filip E; De Smedt Stefaan C; Demeester Jo; Hennink Wim E
Biodegradable microcapsules designed via 'click' chemistry.
Chemical communications (Cambridge, England) 2008;(2):190-2.
2008: Van Tomme Sophie R; Mens Ad; van Nostrum Cornelus F; Hennink Wim E
Macroscopic hydrogels by self-assembly of oligolactate-grafted dextran microspheres.
Biomacromolecules 2008;9(1):158-65.
2008: Carstens Myrra G; van Nostrum Cornelus F; Verrijk Ruud; de Leede Leo G J; Crommelin Daan J A; Hennink Wim E
A mechanistic study on the chemical and enzymatic degradation of PEG-Oligo(epsilon-caprolactone) micelles.
Journal of pharmaceutical sciences 2008;97(1):506-18.
2008: Romberg Birgit; Hennink Wim E; Storm Gert
Sheddable coatings for long-circulating nanoparticles.
Pharmaceutical research 2008;25(1):55-71.
2007: Rijcken Cristianne J F; Hofman Jan-Willem; van Zeeland Femke; Hennink Wim E; van Nostrum Cornelus F
Photosensitiser-loaded biodegradable polymeric micelles: preparation, characterisation and in vitro PDT efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(3):144-53.
2007: Vlugt-Wensink K D F; de Vrueh R; Gresnigt M G; Hoogerbrugge C M; van Buul-Offers S C; de Leede L G J; Sterkman L G W; Crommelin D J A; Hennink W E; Verrijk R
Preclinical and clinical in vitro in vivo correlation of an hGH dextran microsphere formulation.
Pharmaceutical research 2007;24(12):2239-48.
2007: Rijcken Cristianne J; Snel Cor J; Schiffelers Raymond M; van Nostrum Cornelus F; Hennink Wim E
Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies.
Biomaterials 2007;28(36):5581-93.
2007: Romberg Birgit; Oussoren Christien; Snel Cor J; Hennink Wim E; Storm Gert
Effect of liposome characteristics and dose on the pharmacokinetics of liposomes coated with poly(amino acid)s.
Pharmaceutical research 2007;24(12):2394-401.
2007: Paasonen Lauri; Romberg Birgit; Storm Gert; Yliperttula Marjo; Urtti Arto; Hennink Wim E
Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release.
Bioconjugate chemistry 2007;18(6):2131-6.
2007: Oudshoorn Marion H M; Penterman Roel; Rissmann Robert; Bouwstra Joke A; Broer Dirk J; Hennink Wim E
Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol.
Langmuir : the ACS journal of surfaces and colloids 2007;23(23):11819-25.
2007: Jiang Xulin; Lok Martin C; Hennink Wim E
Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery.
Bioconjugate chemistry 2007;18(6):2077-84.
2007: Zielhuis Sander W; Nijsen J Frank W; Seppenwoolde Jan-Henry; Bakker Chris J G; Krijger Gerard C; Dullens Hub F J; Zonnenberg Bernard A; van Rijk Peter P; Hennink Wim E; van het Schip Alfred D
Long-term toxicity of holmium-loaded poly(L-lactic acid) microspheres in rats.
Biomaterials 2007;28(31):4591-9.
2007: Vlugt-Wensink K D F; Meijer Y J; van Steenbergen M J; Verrijk R; Jiskoot W; Crommelin D J A; Hennink W E
Effect of excipients on the encapsulation efficiency and release of human growth hormone from dextran microspheres.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(3):589-96.
2007: De Jong Wim H; Dormans Jan A M A; Van Steenbergen Mies J; Verharen Henny W; Hennink Wim E
Tissue response in the rat and the mouse to degradable dextran hydrogels.
Journal of biomedical materials research. Part A 2007;83(2):538-45.
2007: Lin Chao; Zhong Zhiyuan; Lok Martin C; Jiang Xulin; Hennink Wim E; Feijen Jan; Engbersen Johan F J
Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection.
Journal of controlled release : official journal of the Controlled Release Society 2007;123(1):67-75.
2007: Leemhuis Mark; Kruijtzer John A W; Nostrum Cornelus F van; Hennink Wim E
In vitro hydrolytic degradation of hydroxyl-functionalized poly(alpha-hydroxy acid)s.
Biomacromolecules 2007;8(9):2943-9.
2007: Metz Bernard; Jiskoot Wim; Mekkes Dirk; Kingma Robert; Hennink Wim E; Crommelin Daan J A; Kersten Gideon F A
Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques.
Vaccine 2007;25(39-40):6863-71.
2007: van Hell Albert J; Costa Cristina I C A; Flesch Frits M; Sutter Marc; Jiskoot Wim; Crommelin Daan J A; Hennink Wim E; Mastrobattista Enrico
Self-assembly of recombinant amphiphilic oligopeptides into vesicles.
Biomacromolecules 2007;8(9):2753-61.
2007: Amidi Maryam; Pellikaan Hubert C; Hirschberg Hoang; de Boer Anne H; Crommelin Daan J A; Hennink Wim E; Kersten Gideon; Jiskoot Wim
Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs.
Vaccine 2007;25(37-38):6818-29.
2007: Hiemstra Christine; Zhong Zhiyuan; van Steenbergen Mies J; Hennink Wim E; Feijen Jan
Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(1):71-8.
2007: Zielhuis S W; Seppenwoolde J H; Bakker C J G; Jahnz U; Zonnenberg B A; van het Schip A D; Hennink W E; Nijsen J F W
Characterization of holmium loaded alginate microspheres for multimodality imaging and therapeutic applications.
Journal of biomedical materials research. Part A 2007;82(4):892-8.
2007: Mastrobattista Enrico; Hennink Wim E; Schiffelers Raymond M
Delivery of nucleic acids.
Pharmaceutical research 2007;24(8):1561-3.
2007: Fedorovich Natalja E; Alblas Jacqueline; de Wijn Joost R; Hennink Wim E; Verbout Ab J; Dhert Wouter J A
Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing.
Tissue engineering 2007;13(8):1905-25.
2007: de Wolf Holger K; de Raad Markus; Snel Cor; van Steenbergen Mies J; Fens Marcel H A M; Storm Gert; Hennink Wim E
Biodegradable poly(2-dimethylamino ethylamino)phosphazene for in vivo gene delivery to tumor cells. Effect of polymer molecular weight.
Pharmaceutical research 2007;24(8):1572-80.
2007: van der Aa M A E M; Huth U S; Häfele S Y; Schubert R; Oosting R S; Mastrobattista E; Hennink W E; Peschka-Süss R; Koning G A; Crommelin D J A
Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells.
Pharmaceutical research 2007;24(8):1590-8.
2007: Rijcken C J F; Soga O; Hennink W E; van Nostrum C F
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2007;120(3):131-48.
2007: Hiemstra Christine; Zhong Zhiyuan; Van Tomme Sophie R; van Steenbergen Mies J; Jacobs John J L; Otter Willem Den; Hennink Wim E; Feijen Jan
In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(3):320-7.
2007: Sutter Marc; Siepmann Juergen; Hennink Wim E; Jiskoot Wim
Recombinant gelatin hydrogels for the sustained release of proteins.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(3):301-12.
2007: Hofman Jan-Willem; van Zeeland Femke; Turker Selcan; Talsma Herre; Lambrechts Saskia A G; Sakharov Dmitri V; Hennink Wim E; van Nostrum Cornelus F
Peripheral and axial substitution of phthalocyanines with solketal groups: synthesis and in vitro evaluation for photodynamic therapy.
Journal of medicinal chemistry 2007;50(7):1485-94.
2007: Van Tomme Sophie R; Hennink Wim E
Biodegradable dextran hydrogels for protein delivery applications.
Expert review of medical devices 2007;4(2):147-64.
2007: Sutter Marc; Oliveira Sabrina; Sanders Niek N; Lucas Bart; van Hoek Arie; Hink Mark A; Visser Antonie J W G; De Smedt Stefaan C; Hennink Wim E; Jiskoot Wim
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.
Journal of fluorescence 2007;17(2):181-92.
2007: Romberg Birgit; Oussoren Christien; Snel Cor J; Carstens Myrra G; Hennink Wim E; Storm Gert
Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration.
Biochimica et biophysica acta 2007;1768(3):737-43.
2007: Romberg Birgit; Metselaar Josbert M; Baranyi Lajos; Snel Cor J; Bünger Rolf; Hennink Wim E; Szebeni Janos; Storm Gert
Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes.
International journal of pharmaceutics 2007;331(2):186-9.
2007: de Wolf Holger K; Snel Cor J; Verbaan Ferry J; Schiffelers Raymond M; Hennink Wim E; Storm Gert
Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration.
International journal of pharmaceutics 2007;331(2):167-75.
2007: Dijk Maarten van; Mustafa Khalid; Dechesne Annemarie C; Nostrum Cornelus F van; Hennink Wim E; Rijkers Dirk T S; Liskamp Rob M J
Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization.
Biomacromolecules 2007;8(2):327-30.
2007: Lammers Twan; Peschke Peter; Kühnlein Rainer; Subr Vladimir; Ulbrich Karel; Debus Jürgen; Huber Peter; Hennink Wim; Storm Gert
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):333-41.
2007: Lin Chao; Zhong Zhiyuan; Lok Martin C; Jiang Xulin; Hennink Wim E; Feijen Jan; Engbersen Johan F J
Novel bioreducible poly(amido amine)s for highly efficient gene delivery.
Bioconjugate chemistry 2007;18(1):138-45.
2006: Zhong Z Y; Lin C; Ma Y; Hempenius M A; Lok M C; Fretz M M; Engbersen J F J; Vancso G J; Hennink W E; Feijen J
Water-soluble cationic poly(ferrocenylsilane): an efficient DNA condensation and transfection agent.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e81-3.
2006: Lin C; Lammens T M; Zhong Z Y; Gu H; Lok M C; Jiang X; Hennink W E; Feijen J; Engbersen J F J
Disulfide-containing poly(beta-amino ester)s for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e79-81.
2006: Jiang X; van der Horst A; van Steenbergen M J; Akeroyd N; van Nostrum C F; Schoenmakers P J; Hennink W E
Aqueous size-exclusion chromatography of cationic polymers for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e69-71.
2006: Carstens M G; van Nostrum C F; Ramzi A; de Leede L G J; Crommelin D J A; Hennink W E
Self-assembly of PEG-oligolactates with monodisperse hydrophobic blocks.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e40-1.
2006: Hiemstra C; Zhong Z Y; Van Tomme S R; Hennink W E; Dijkstra P J; Feijen J
Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e19-21.
2006: Hiemstra C; Zhong Z Y; Jiang X; Hennink W E; Dijkstra P J; Feijen J
PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e17-9.
2006: Rijcken C J F; Leemhuis M; Hofman J-W; van Zeeland F; Ramzi A; van Nostrum C F; Hennink W E
Methacrylamide-oligolactates as building blocks for targeted biodegradable polymeric micelles to deliver photosensitizers.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e10-2.
2006: Vermonden Tina; M Nicolaas A; van Mies J; Hennink Wim E
Rheological studies of thermosensitive triblock copolymer hydrogels.
Langmuir : the ACS journal of surfaces and colloids 2006;22(24):10180-4.
2006: Vlugt-Wensink Karin D F; Jiang Xulin; Schotman Geert; Kruijtzer Govert; Vredenberg Arjen; Chung Jin T; Zhang Zhibing; Versluis Cees; Ramos Delphine; Verrijk Ruud; Jiskoot Wim; Crommelin Daan J A; Hennink Wim E
In vitro degradation behavior of microspheres based on cross-linked dextran.
Biomacromolecules 2006;7(11):2983-90.
2006: Lin Chao; Zhong Zhiyuan; Lok Martin C; Jiang Xulin; Hennink Wim E; Feijen Jan; Engbersen Johan F J
Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):130-7.
2006: Oudshoorn Marion H M; Rissmann Robert; Bouwstra Joke A; Hennink Wim E
Synthesis and characterization of hyperbranched polyglycerol hydrogels.
Biomaterials 2006;27(32):5471-9.
2006: Lammers Twan; Peschke Peter; Kühnlein Rainer; Subr Vladimir; Ulbrich Karel; Huber Peter; Hennink Wim; Storm Gert
Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems.
Neoplasia (New York, N.Y.) 2006;8(10):788-95.
2006: Ramzi A; Sutter M; Hennink W E; Jiskoot W
Static light scattering and small-angle neutron scattering study on aggregated recombinant gelatin in aqueous solution.
Journal of pharmaceutical sciences 2006;95(8):1703-11.
2006: Van Tomme Sophie R; van Nostrum Cornelus F; de Smedt Stefaan C; Hennink Wim E
Degradation behavior of dextran hydrogels composed of positively and negatively charged microspheres.
Biomaterials 2006;27(22):4141-8.
2006: Luten Jordy; Akeroyd Niels; Funhoff Arjen; Lok Martin C; Talsma Herre; Hennink Wim E
Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers.
Bioconjugate chemistry 2006;17(4):1077-84.
2006: Zielhuis Sander W; Nijsen Johannes F W; Krijger Gerard C; van het Schip Alfred D; Hennink Wim E
Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study.
Biomacromolecules 2006;7(7):2217-23.
2006: van Gaal Ethlinn V B; Hennink Wim E; Crommelin Daan J A; Mastrobattista Enrico
Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy.
Pharmaceutical research 2006;23(6):1053-74.
2006: Zielhuis S W; Nijsen J F W; Dorland L; Krijger G C; van Het Schip A D; Hennink W E
Removal of chloroform from biodegradable therapeutic microspheres by radiolysis.
International journal of pharmaceutics 2006;315(1-2):67-74.
2006: Romberg Birgit; Kettenes-van den Bosch J Jantina; de Vringer Tom; Storm Gert; Hennink Wim E
1H NMR spectroscopy as a tool for determining the composition of poly(hydroxyethyl-L-asparagine)-coated liposomes.
Bioconjugate chemistry 2006;17(3):860-4.
2006: Metz Bernard; Kersten Gideon F A; Baart Gino J E; de Jong Ad; Meiring Hugo; ten Hove Jan; van Steenbergen Mies J; Hennink Wim E; Crommelin Daan J A; Jiskoot Wim
Identification of formaldehyde-induced modifications in proteins: reactions with insulin.
Bioconjugate chemistry 2006;17(3):815-22.
2006: van der Aa Marieke A E M; Mastrobattista Enrico; Oosting Ronald S; Hennink Wim E; Koning Gerben A; Crommelin Daan J A
The nuclear pore complex: the gateway to successful nonviral gene delivery.
Pharmaceutical research 2006;23(3):447-59.
2006: Jiang Xulin; van der Horst Aschwin; van Steenbergen Mies J; Akeroyd Niels; van Nostrum Cornelus F; Schoenmakers Peter J; Hennink Wim E
Molar-mass characterization of cationic polymers for gene delivery by aqueous size-exclusion chromatography.
Pharmaceutical research 2006;23(3):595-603.
2006: Zielhuis S W; Nijsen J F W; de Roos R; Krijger G C; van Rijk P P; Hennink W E; van het Schip A D
Production of GMP-grade radioactive holmium loaded poly(L-lactic acid) microspheres for clinical application.
International journal of pharmaceutics 2006;311(1-2):69-74.
2006: Vlugt-Wensink Karin D F; Vlugt Thijs J H; Jiskoot Wim; Crommelin Daan J A; Verrijk Ruud; Hennink Wim E
Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):117-27.
2006: Amidi Maryam; Romeijn Stefan G; Borchard Gerrit; Junginger Hans E; Hennink Wim E; Jiskoot Wim
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):107-16.
2006: Bonsted Anette; Engesaeter Birgit Øvstebø; Høgset Anders; Maelandsmo Gunhild M; Prasmickaite Lina; D'Oliveira Christine; Hennink Wim E; van Steenis Jan Hein; Berg Kristian
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor.
The journal of gene medicine 2006;8(3):286-97.
2006: Mastrobattista Enrico; van der Aa Marieke A E M; Hennink Wim E; Crommelin Daan J A
Artificial viruses: a nanotechnological approach to gene delivery.
Nature reviews. Drug discovery 2006;5(2):115-21.
2005: Van Tomme Sophie R; De Geest Bruno G; Braeckmans Kevin; De Smedt Stefaan C; Siepmann Florence; Siepmann Juergen; van Nostrum Cornelus F; Hennink Wim E
Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):67-78.
2005: Zhong Zhiyuan; Song Yan; Engbersen Johan F J; Lok Martin C; Hennink Wim E; Feijen Jan
A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):317-29.
2005: de Wolf Holger K; Luten Jordy; Snel Cor J; Oussoren Christien; Hennink Wim E; Storm Gert
In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):275-87.
2005: Carstens Myrra G; van Nostrum Cornelus F; Ramzi Aissa; Meeldijk Johannes D; Verrijk Ruud; de Leede Leo L; Crommelin Daan J A; Hennink Wim E
Poly(ethylene glycol)--oligolactates with monodisperse hydrophobic blocks: preparation, characterization, and behavior in water.
Langmuir : the ACS journal of surfaces and colloids 2005;21(24):11446-54.
2005: Zhong Zhiyuan; Feijen Jan; Lok Martin C; Hennink Wim E; Christensen Lane V; Yockman James W; Kim Yong-Hee; Kim Sung Wan
Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties.
Biomacromolecules 2005;6(6):3440-8.
2005: Verbaan Ferry J; Klein Klouwenberg Peter; van Steenis Jan Hein; Snel Cor J; Boerman Otto; Hennink Wim E; Storm Gert
Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells.
International journal of pharmaceutics 2005;304(1-2):185-92.
2005: Zhao Yixian; Benita Yair; Lok Martin; Kuipers Betsy; van der Ley Peter; Jiskoot Wim; Hennink Wim E; Crommelin Daan J A; Oosting Ronald S
Multi-antigen immunization using IgG binding domain ZZ as carrier.
Vaccine 2005;23(43):5082-90.
2005: Arigita Carmen; Luijkx Thomas; Jiskoot Wim; Poelen Martien; Hennink Wim E; Crommelin Daan J A; Ley Peter van der; Els Cecile van; Kersten Gideon F A
Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives.
Vaccine 2005;23(43):5091-8.
2005: Pires Nuno M M; van der Hoeven Barend L; de Vries Margreet R; Havekes Louis M; van Vlijmen Bart J; Hennink Wim E; Quax Paul H A; Jukema J Wouter
Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff.
Biomaterials 2005;26(26):5386-94.
2005: Romberg Birgit; Metselaar Josbert M; deVringer Tom; Motonaga Kei; Kettenes-van den Bosch J Jantina; Oussoren Christien; Storm Gert; Hennink Wim E
Enzymatic degradation of liposome-grafted poly(hydroxyethyl L-glutamine).
Bioconjugate chemistry 2005;16(4):767-74.
2005: Rijcken Cristianne J F; Veldhuis Theo F J; Ramzi Aissa; Meeldijk Johannes D; van Nostrum Cornelus F; Hennink Wim E
Novel fast degradable thermosensitive polymeric micelles based on PEG-block-poly(N-(2-hydroxyethyl)methacrylamide-oligolactates).
Biomacromolecules 2005;6(4):2343-51.
2005: Bos Gert W; Hennink Wim E; Brouwer Linda A; den Otter Wim; Veldhuis Theo F J; van Nostrum Cornelus F; van Luyn Marja J A
Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats.
Biomaterials 2005;26(18):3901-9.
2005: Zielhuis S W; Nijsen J F W; Seppenwoolde J H; Zonnenberg B A; Bakker C J G; Hennink W E; van Rijk P P; van het Schip A D
Lanthanide bearing microparticulate systems for multi-modality imaging and targeted therapy of cancer.
Current medicinal chemistry. Anti-cancer agents 2005;5(3):303-13.
2005: Van Tomme Sophie R; van Steenbergen Mies J; De Smedt Stefaan C; van Nostrum Cornelus F; Hennink Wim E
Self-gelling hydrogels based on oppositely charged dextran microspheres.
Biomaterials 2005;26(14):2129-35.
2005: Soga Osamu; van Nostrum Cornelus F; Fens Marcel; Rijcken Cristianne J F; Schiffelers Raymond M; Storm Gert; Hennink Wim E
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):341-53.
2005: Zielhuis S W; Nijsen J F W; Figueiredo R; Feddes B; Vredenberg A M; van het Schip A D; Hennink W E
Surface characteristics of holmium-loaded poly(L-lactic acid) microspheres.
Biomaterials 2005;26(8):925-32.
2005: Funhoff Arjen M; Monge Sophie; Teeuwen Rosalie; Koning Gerben A; Schuurmans-Nieuwenbroek Nancy M E; Crommelin Daan J A; Haddleton David M; Hennink Wim E; van Nostrum Cornelus F
PEG shielded polymeric double-layered micelles for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2005;102(3):711-24.
2005: van der Aa M A E M; Koning G A; d'Oliveira C; Oosting R S; Wilschut K J; Hennink W E; Crommelin D J A
An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems.
The journal of gene medicine 2005;7(2):208-17.
2005: Zhong Z; Lok M C; Dijkstra P J; Hennink W E; Feijen J
Structurally well-defined copolymers of poly(ethylene glycol) and low molecular weight linear polyethylenimine as vectors for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):406-8.
2005: van der Aa M; Koning G; van der Gugten J; d'Oliveira C; Oosting R; Hennink W E; Crommelin D J A
Covalent attachment of an NLS-peptide to linear dna does not enhance transfection efficiency of cationic polymer based gene delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):395-7.
2005: Soga O; van Nostrum C F; Hennink W E
Thermosensitive and biodegradable polymeric micelles with transient stability.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):383-5.
2005: Chung J T; Vlugt-Wensink K D F; Hennink W E; Zhang Z
Effect of polymerization conditions on the network properties of dex-HEMA microspheres and macro-hydrogels.
International journal of pharmaceutics 2005;288(1):51-61.
2005: Funhoff Arjen M; van Nostrum Cornelus F; Lok Martin C; Kruijtzer John A W; Crommelin Daan J A; Hennink Wim E
Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):233-46.
2004: Vermonden Tina; van Steenbergen Mies J; Besseling Nicolaas A M; Marcelis Antonius T M; Hennink Wim E; Sudhölter Ernst J R; Cohen Stuart Martien A
Linear rheology of water-soluble reversible neodymium(III) coordination polymers.
Journal of the American Chemical Society 2004;126(48):15802-8.
2004: Bos Gert W; Kanellos Theofanis; Crommelin Daan J A; Hennink Wim E; Howard Colin R
Cationic polymers that enhance the performance of HbsAg DNA in vivo.
Vaccine 2004;23(4):460-9.
2004: Funhoff Arjen M; van Nostrum Cornelus F; Lok Martin C; Fretz Marjan M; Crommelin Daan J A; Hennink Wim E
Poly(3-guanidinopropyl methacrylate): a novel cationic polymer for gene delivery.
Bioconjugate chemistry 2004;15(6):1212-20.
2004: Soga Osamu; van Nostrum Cornelus F; Ramzi Aissa; Visser Tom; Soulimani Fouad; Frederik Peter M; Bomans Paul H H; Hennink Wim E
Physicochemical characterization of degradable thermosensitive polymeric micelles.
Langmuir : the ACS journal of surfaces and colloids 2004;20(21):9388-95.
2004: Hennink W E; De Jong S J; Bos G W; Veldhuis T F J; van Nostrum C F
Biodegradable dextran hydrogels crosslinked by stereocomplex formation for the controlled release of pharmaceutical proteins.
International journal of pharmaceutics 2004;277(1-2):99-104.
2004: Soga Osamu; van Nostrum Cornelus F; Hennink Wim E
Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity.
Biomacromolecules 2004;5(3):818-21.
2004: Neradovic D; Soga O; Van Nostrum C F; Hennink W E
The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups.
Biomaterials 2004;25(12):2409-18.
2004: Yilmaz Gülden; Jongboom Remy O J; Feil Herman; van Dijk Cees; Hennink Wim E
Permeation of volatile compounds through starch films.
Biomacromolecules 2004;5(2):650-6.
2004: Bos Gert W; Jacobs John J L; Koten Jan Willem; Van Tomme Sophie; Veldhuis Theo; van Nostrum Cornelus F; Den Otter Willem; Hennink Wim E
In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(4):561-7.
2004: Arigita Carmen; van den Berg Joost; Wensink Karin; van Steenbergen Mies; Hennink Wim E; Crommelin Daan J A; Kersten Gideon F A; Jiskoot Wim
Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(2-3):131-41.
2004: Metz Bernard; Kersten Gideon F A; Hoogerhout Peter; Brugghe Humphrey F; Timmermans Hans A M; de Jong Ad; Meiring Hugo; ten Hove Jan; Hennink Wim E; Crommelin Daan J A; Jiskoot Wim
Identification of formaldehyde-induced modifications in proteins: reactions with model peptides.
The Journal of biological chemistry 2004;279(8):6235-43.
2004: Funhoff Arjen M; van Nostrum Cornelus F; Janssen Adriënne P C A; Fens Marcel H A M; Crommelin Daan J A; Hennink Wim E
Polymer side-chain degradation as a tool to control the destabilization of polyplexes.
Pharmaceutical research 2004;21(1):170-6.
2004: Arigita Carmen; Jiskoot Wim; Westdijk Janny; van Ingen Cor; Hennink Wim E; Crommelin Daan J A; Kersten Gideon F A
Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines.
Vaccine 2004;22(5-6):629-42.
2004: Verbaan F J; Oussoren C; Snel C J; Crommelin D J A; Hennink W E; Storm G
Steric stabilization of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes mediates prolonged circulation and tumor targeting in mice.
The journal of gene medicine 2004;6(1):64-75.
2004: Funhoff Arjen M; van Nostrum Cornelus F; Koning Gerben A; Schuurmans-Nieuwenbroek Nancy M E; Crommelin Daan J A; Hennink Wim E
Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH.
Biomacromolecules 2004;5(1):32-9.
2003: Verbaan Ferry; van Dam Inger; Takakura Yoshinubu; Hashida Mitsuru; Hennink Wim; Storm Gert; Oussoren Christien
Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(4-5):419-27.
2003: Metz Bernard; Jiskoot Wim; Hennink Wim E; Crommelin Daan J A; Kersten Gideon F A
Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines.
Vaccine 2003;22(2):156-67.
2003: Metselaar Josbert M; Bruin Peter; de Boer Leo W T; de Vringer Tom; Snel Cor; Oussoren Christien; Wauben Marca H M; Crommelin Daan J A; Storm Gert; Hennink Wim E
A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity.
Bioconjugate chemistry 2003;14(6):1156-64.
2003: Koten J W; Van Luyn M J A; Cadée J A; Brouwer L; Hennink W E; Bijleveld C; Den Otter W
IL-2 loaded dextran microspheres with attractive histocompatibility properties for local IL-2 cancer therapy.
Cytokine 2003;24(3):57-66.
2003: Crommelin Daan J A; Storm Gert; Verrijk Ruud; de Leede Leo; Jiskoot Wim; Hennink Wim E
Shifting paradigms: biopharmaceuticals versus low molecular weight drugs.
International journal of pharmaceutics 2003;266(1-2):3-16.
2003: Arigita Carmen; Bevaart Lisette; Everse Linda A; Koning Gerben A; Hennink Wim E; Crommelin Daan J A; van de Winkel Jan G J; van Vugt Martine J; Kersten Gideon F A; Jiskoot Wim
Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response.
Infection and immunity 2003;71(9):5210-8.
2003: Stubbe Barbara G; Horkay Ferenc; Amsden Brian; Hennink Wim E; De Smedt Stefaan C; Demeester Jo
Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels.
Biomacromolecules 2003;4(3):691-5.
2003: Luten J; van Steenis J H; van Someren R; Kemmink J; Schuurmans-Nieuwenbroek N M E; Koning G A; Crommelin D J A; van Nostrum C F; Hennink W E
Water-soluble biodegradable cationic polyphosphazenes for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(3):483-97.
2003: van Steenis J H; van Maarseveen E M; Verbaan F J; Verrijk R; Crommelin D J A; Storm G; Hennink W E
Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):167-76.
2003: Crommelin Daan J A; Storm Gert; Jiskoot Wim; Stenekes Robert; Mastrobattista Enrico; Hennink Wim E
Nanotechnological approaches for the delivery of macromolecules.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):81-8.
2003: Arigita Carmen; Kersten Gideon F A; Hazendonk Ton; Hennink Wim E; Crommelin Daan J A; Jiskoot Wim
Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes.
Vaccine 2003;21(9-10):950-60.
2002: Meyvis Tom K L; Stubbe Barbara G; Van Steenbergen Mies J; Hennink Wim E; De Smedt Stefaan C; Demeester Joseph
A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels.
International journal of pharmaceutics 2002;244(1-2):163-8.
2002: van de Weert Marco; van Dijkhuizen-Radersma Riemke; Bezemer Jeroen M; Hennink Wim E; Crommelin Daan J A
Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2002;54(1):89-93.
2002: Nijsen J F; van Het Schip A D; van Steenbergen M J; Zielhuis S W; Kroon-Batenburg L M J; van de Weert M; van Rijk P P; Hennink W E
Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres.
Biomaterials 2002;23(8):1831-9.
2002: van de Weert Marco; van Steenbergen Marinus J; Cleland Jeffrey L; Heller Jorge; Hennink Wim E; Crommelin Daan J A
Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues.
Journal of pharmaceutical sciences 2002;91(4):1065-74.
2002: Yilmaz Gülden; Ongen Gaye; Jongboom Remy O J; Feil Herman; van Dijk Cees; Hennink Wim E
Modulated release of a volatile compound from starch matrixes via enzymatically controlled degradation.
Biomacromolecules 2002;3(2):305-11.
2002: De Groot Cornelis J; Cadée Jenny A; Koten Jan-Willem; Hennink Wim E; Den Otter Willem
Therapeutic efficacy of IL-2-loaded hydrogels in a mouse tumor model.
International journal of cancer. Journal international du cancer 2002;98(1):134-40.
2002: Nijsen J F W; van het Schip A D; Hennink W E; Rook D W; van Rijk P P; de Klerk J M H
Advances in nuclear oncology: microspheres for internal radionuclide therapy of liver tumours.
Current medicinal chemistry 2002;9(1):73-82.
2002: Cadée J A; de Groot C J; Jiskoot W; den Otter W; Hennink W E
Release of recombinant human interleukin-2 from dextran-based hydrogels.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):1-13.
2002: Hennink W E; van Nostrum C F
Novel crosslinking methods to design hydrogels.
Advanced drug delivery reviews 2002;54(1):13-36.
2001: Meyvis T; De Smedt S; Stubbe B; Hennink W; Demeester J
On the release of proteins from degrading dextran methacrylate hydrogels and the correlation with the rheologic properties of the hydrogels.
Pharmaceutical research 2001;18(11):1593-9.
2001: Nijsen J F; van Steenbergen M J; Kooijman H; Talsma H; Kroon-Batenburg L M; van De Weert M; van Rijk P P; De Witte A; Van Schip A D; Hennink W E
Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate.
Biomaterials 2001;22(22):3073-81.
2001: Cadée J A; van Steenbergen M J; Versluis C; Heck A J; Underberg W J; den Otter W; Jiskoot W; Hennink W E
Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate.
Pharmaceutical research 2001;18(10):1461-7.
2001: van Es R J; Nijsen J F; Dullens H F; Kicken M; van der Bilt A; Hennink W; Koole R; Slootweg P J
Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2001;29(5):289-97.
2001: van de Weert M; Haris P I; Hennink W E; Crommelin D J
Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors.
Analytical biochemistry 2001;297(2):160-9.
2001: Cadée J A; Brouwer L A; den Otter W; Hennink W E; van Luyn M J
A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats.
Journal of biomedical materials research 2001;56(4):600-9.
2001: Stenekes R J; Talsma H; Hennink W E
Formation of dextran hydrogels by crystallization.
Biomaterials 2001;22(13):1891-8.
2001: Mastrobattista E; Kapel R H; Eggenhuisen M H; Roholl P J; Crommelin D J; Hennink W E; Storm G
Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells.
Cancer gene therapy 2001;8(6):405-13.
2001: Nijsen F; Rook D; Brandt C; Meijer R; Dullens H; Zonnenberg B; de Klerk J; van Rijk P; Hennink W; van het Schip F
Targeting of liver tumour in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study.
European journal of nuclear medicine 2001;28(6):743-9.
2001: De Groot C J; Van Luyn M J; Van Dijk-Wolthuis W N; Cadée J A; Plantinga J A; Den Otter W; Hennink W E
In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts.
Biomaterials 2001;22(11):1197-203.
2001: de Jong S J; De Smedt S C; Demeester J; van Nostrum C F; Kettenes-van den Bosch J J; Hennink W E
Biodegradable hydrogels based on stereocomplex formation between lactic acid oligomers grafted to dextran.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):47-56.
2001: de Jong S J; van Eerdenbrugh B; van Nostrum C F; Kettenes-van den Bosch J J; Hennink W E
Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behavior.
Journal of controlled release : official journal of the Controlled Release Society 2001;71(3):261-75.
2001: Verbaan F J; Oussoren C; van Dam I M; Takakura Y; Hashida M; Crommelin D J; Hennink W E; Storm G
The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration.
International journal of pharmaceutics 2001;214(1-2):99-101.
2001: Stenekes R J; Loebis A E; Fernandes C M; Crommelin D J; Hennink W E
Degradable dextran microspheres for the controlled release of liposomes.
International journal of pharmaceutics 2001;214(1-2):17-20.
2000: Bos G W; Trullas-Jimeno A; Jiskoot W; Crommelin D J; Hennink W E
Sterilization of poly(dimethylamino) ethyl methacrylate-based gene transfer complexes.
International journal of pharmaceutics 2000;211(1-2):79-88.
2000: van de Weert M; Hennink W E; Jiskoot W
Protein instability in poly(lactic-co-glycolic acid) microparticles.
Pharmaceutical research 2000;17(10):1159-67.
2000: van de Weert M; Hoechstetter J; Hennink W E; Crommelin D J
The effect of a water/organic solvent interface on the structural stability of lysozyme.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(3):351-9.
2000: van de Weert M; van 't Hof1 R; van der Weerd J; Heeren R M; Posthuma G; Hennink W E; Crommelin D J
Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(1):31-40.
2000: Stenekes R J; Loebis A E; Fernandes C M; Crommelin D J; Hennink W E
Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept.
Pharmaceutical research 2000;17(6):690-5.
2000: Cadée J A; van Luyn M J; Brouwer L A; Plantinga J A; van Wachem P B; de Groot C J; den Otter W; Hennink W E
In vivo biocompatibility of dextran-based hydrogels.
Journal of biomedical materials research 2000;50(3):397-404.
2000: De Smedt S C; Demeester J; Hennink W E
Cationic polymer based gene delivery systems.
Pharmaceutical research 2000;17(2):113-26.
2000: van de Wetering P; Schuurmans-Nieuwenbroek N M; van Steenbergen M J; Crommelin D J; Hennink W E
Copolymers of 2-(dimethylamino)ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):193-203.
2000: Stenekes R J; De Smedt S C; Demeester J; Sun G; Zhang Z; Hennink W E
Pore sizes in hydrated dextran microspheres.
Biomacromolecules 2000;1(4):696-703.
2000: Zuidam N J; Posthuma G; de Vries E T; Crommelin D J; Hennink W E; Storm G
Effects of physicochemical characteristics of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes on cellular association and internalization.
Journal of drug targeting 2000;8(1):51-66.
1999: Fonseca M J; Storm G; Hennink W E; Gerritsen W R; Haisma H J
Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy.
The journal of gene medicine 1999;1(6):407-14.
1999: Stenekes R J; Hennink W E
Equilibrium water content of microspheres based on cross-linked dextran.
International journal of pharmaceutics 1999;189(2):131-5.
1999: Arigita C; Zuidam N J; Crommelin D J; Hennink W E
Association and dissociation characteristics of polymer/DNA complexes used for gene delivery.
Pharmaceutical research 1999;16(10):1534-41.
1999: Otter W D; Cadée J; Gavhumende R; De Groot C J; Hennink W E; Stewart R
Effective cancer therapy with a single injection of interleukin-2 at the site of the tumour.
Cancer immunology, immunotherapy : CII 1999;48(7):419-20.
1999: Cherng J Y; Talsma H; Crommelin D J; Hennink W E
Long term stability of poly((2-dimethylamino)ethyl methacrylate)-based gene delivery systems.
Pharmaceutical research 1999;16(9):1417-23.
1999: Cherng J Y; Schuurmans-Nieuwenbroek N M; Jiskoot W; Talsma H; Zuidam N J; Hennink W E; Crommelin D J
Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):343-53.
1999: Hinrichs W L; Schuurmans-Nieuwenbroek N M; van de Wetering P; Hennink W E
Thermosensitive polymers as carriers for DNA delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):249-59.
1999: Franssen O; Vandervennet L; Roders P; Hennink W E
Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):211-21.
1999: van Dijk-Wolthuis W N; van de Wetering P; Hinrichs W L; Hofmeyer L J; Liskamp R M; Crommelin D J; Hennink W E
A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate].
Bioconjugate chemistry 1999;10(4):687-92.
1999: van de Wetering P; Moret E E; Schuurmans-Nieuwenbroek N M; van Steenbergen M J; Hennink W E
Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery.
Bioconjugate chemistry 1999;10(4):589-97.
1999: Stenekes R J; Franssen O; van Bommel E M; Crommelin D J; Hennink W E
The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres.
International journal of pharmaceutics 1999;183(1):29-32.
1999: Cherng J Y; vd Wetering P; Talsma H; Crommelin D J; Hennink W E
Stabilization of polymer-based gene delivery systems.
International journal of pharmaceutics 1999;183(1):25-8.
1999: van de Wetering P; Schuurmans-Nieuwenbroek N M; Hennink W E; Storm G
Comparative transfection studies of human ovarian carcinoma cells in vitro, ex vivo and in vivo with poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes.
The journal of gene medicine 1999;1(3):156-65.
1999: Den Otter W; Balemans L; Battermann J J; Bernsen M R; Cadee J A; Dobrowolski Z; Everse L A; Fiszer-Maliszewska L; Gavhumende R; De Groot J W; De Groot K; Hennink W E; Hill F W; Jurgenliemp-Schulz I; Klein W R; Koten J W; Maas R A; Steerenberg P; Stewart R; Zembala M
Local low-dose IL-2 therapy.
Hepato-gastroenterology 1999;46 Suppl 1():1280-6.
1999: Cherng J Y; Talsma H; Verrijk R; Crommelin D J; Hennink W E
The effect of formulation parameters on the size of poly-((2-dimethylamino)ethyl methacrylate)-plasmid complexes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1999;47(3):215-24.
1999: Franssen O; Stenekes R J; Hennink W E
Controlled release of a model protein from enzymatically degrading dextran microspheres.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(2):219-28.
1999: van Es R J; Franssen O; Dullens H F; Bernsen M R; Bosman F; Hennink W E; Slootweg P J
The VX2 carcinoma in the rabbit auricle as an experimental model for intra-arterial embolization of head and neck squamous cell carcinoma with dextran microspheres.
Laboratory animals 1999;33(2):175-84.
1998: van de Wetering P; Cherng J Y; Talsma H; Crommelin D J; Hennink W E
2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):145-53.
1998: Stenekes R J; Franssen O; van Bommel E M; Crommelin D J; Hennink W E
The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics.
Pharmaceutical research 1998;15(4):557-61.
1997: Cherng J Y; van de Wetering P; Talsma H; Crommelin D J; Hennink W E
Freeze-drying of poly((2-dimethylamino)ethyl methacrylate)-based gene delivery systems.
Pharmaceutical research 1997;14(12):1838-41.
1997: van Dijk-Wolthuis W N; van Steenbergen M J; Underberg W J; Hennink W E
Degradation kinetics of methacrylated dextrans in aqueous solution.
Journal of pharmaceutical sciences 1997;86(4):413-7.
1996: Cherng J Y; van de Wetering P; Talsma H; Crommelin D J; Hennink W E
Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles.
Pharmaceutical research 1996;13(7):1038-42.
1990: Deurloo M J; Bohlken S; Kop W; Lerk C F; Hennink W; Bartelink H; Begg A C
Intratumoural administration of cisplatin in slow-release devices. I. Tumour response and toxicity.
Cancer chemotherapy and pharmacology 1990;27(2):135-40.

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