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Jean-Claude Henquin

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Jean-Claude Henquin; Joelle Marchandise; Myriam Nenquin; Sebastien Godecharles; Yves Guiot; Christine Sempoux; Jacques Rahier
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.
Nizar I Mourad; Myriam Nenquin; Jean-Claude Henquin
Amplification of insulin secretion by acetylcholine or phorbol ester is independent of β-cell microfilaments and distinct from metabolic amplification.
Eléonore Dubois; Christophe Erneux; Lazaros C Foukas; Jean-Claude Henquin; Monique Jacoby; Eileen Pernot; Serge N Schiffmann; Marianne Blockmans; Bart Vanhaesebroeck; Stéphane Schurmans
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

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2013: Jean-Claude Henquin; Joelle Marchandise; Myriam Nenquin; Sebastien Godecharles; Yves Guiot; Christine Sempoux; Jacques Rahier
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.
Diabetes 2013;62(5):1689-96.
2013: Nizar I Mourad; Myriam Nenquin; Jean-Claude Henquin
Amplification of insulin secretion by acetylcholine or phorbol ester is independent of β-cell microfilaments and distinct from metabolic amplification.
Molecular and cellular endocrinology 2013;367(1-2):11-20.
2012: Eléonore Dubois; Christophe Erneux; Lazaros C Foukas; Jean-Claude Henquin; Monique Jacoby; Eileen Pernot; Serge N Schiffmann; Marianne Blockmans; Bart Vanhaesebroeck; Stéphane Schurmans
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Cellular signalling 2012;24(11):1971-80.
2012: Nizar I Mourad; Myriam Nenquin; Jean-Claude Henquin
cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments.
Endocrinology 2012;153(10):4644-54.
2012: Jean-Claude Henquin
Do pancreatic β cells "taste" nutrients to secrete insulin?
Science signaling 2012;5(239):pe36.
2011: Jean-Claude Henquin; Myriam Nenquin; Claire Nihoul-Fékété; Timo Otonkoski; Christine Bellanné-Chantelot; Pascale de Lonlay; Yves Guiot; Christine Sempoux; Jacques Rahier
In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.
The Journal of clinical investigation 2011;121(10):3932-42.
2011: Jean-Claude Henquin
The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells.
Diabetes research and clinical practice 2011;93 Suppl 1():S27-31.
2011: Jean-Claude Henquin; Jacques Rahier
Pancreatic alpha cell mass in European subjects with type 2 diabetes.
Diabetologia 2011;54(7):1720-5.
2011: Nizar I Mourad; Myriam Nenquin; Jean-Claude Henquin
Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules.
American journal of physiology. Cell physiology 2011;300(3):C697-706.
2010: Magalie A Ravier; R Cheng-Xue; A E Palmer; Jean-Claude Henquin; Patrick Gilon
Subplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion.
Diabetologia 2010;53(9):1947-57.
2010: Nizar I Mourad; Myriam Nenquin; Jean-Claude Henquin
Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments.
American journal of physiology. Cell physiology 2010;299(2):C389-98.
2010: Andras Szollosi; Myriam Nenquin; Jean-Claude Henquin
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.
British journal of pharmacology 2010;159(3):669-77.
2009: Jean-Claude Henquin; Myriam Nenquin; Magalie A Ravier; Andras Szollosi
Shortcomings of current models of glucose-induced insulin secretion.
Diabetes, obesity & metabolism 2009;11 Suppl 4():168-79.
2009: Bo Ahrén; Domenico Accili; Christian Boitard; Suad Efendic; Jean-Claude Henquin; Susumu Seino; Donald F Steiner; Erol Cerasi
β-Cell research - A decade of rapid growth.
Diabetes, obesity & metabolism 2009;11 Suppl 4():iv-ix.
2009: Nicolas Quoix; Rui Cheng-Xue; Laurine Mattart; Ziad Zeinoun; Yves Guiot; Mélanie C Beauvois; Jean-Claude Henquin; Patrick Gilon
Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.
Diabetes 2009;58(2):412-21.
2009: Magalie A Ravier; Myriam Nenquin; Takashi Miki; Susumu Seino; Jean-Claude Henquin
Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.
Endocrinology 2009;150(1):33-45.
2008: Jacques Rahier; Yves Guiot; R M Goebbels; C Sempoux; Jean-Claude Henquin
Pancreatic beta-cell mass in European subjects with type 2 diabetes.
Diabetes, obesity & metabolism 2008;10 Suppl 4():32-42.
2008: Jean-Claude Henquin; Erol Cerasi; Suad Efendic; Donald F Steiner; Christian Boitard
Pancreatic beta-cell mass or beta-cell function? That is the question!
Diabetes, obesity & metabolism 2008;10 Suppl 4():1-4.
2008: Jean-Claude Henquin; Myriam Nenquin; Andras Szollosi; Atsutaka Kubosaki; A L Notkins
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.
The Journal of endocrinology 2008;196(3):573-81.
2007: Denis Dufrane; Myriam Nenquin; Jean-Claude Henquin
Nutrient control of insulin secretion in perifused adult pig islets.
Diabetes & metabolism 2007;33(6):430-8.
2007: Suad Efendic; Christian Boitard; Ele Ferrannini; Jean-Claude Henquin; Donald F Steiner; Erol Cerasi
Of mighty mice and diabetic men: animal models of islet dysfunction.
Diabetes, obesity & metabolism 2007;9 Suppl 2():1-4.
2007: Nicolas Quoix; Rui Cheng-Xue; Yves Guiot; Pedro L Herrera; Jean-Claude Henquin; Patrick Gilon
The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.
FEBS letters 2007;581(22):4235-40.
2007: Yves Guiot; M Stevens; I Marhfour; Patrick Stiernet; Michael V Mikhailov; S J H Ashcroft; Jacques Rahier; Jean-Claude Henquin; C Sempoux
Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.
Diabetologia 2007;50(9):1889-99.
2007: Patrick Stiernet; Myriam Nenquin; Pierre Moulin; Jean-Christophe Jonas; Jean-Claude Henquin
Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1.
The Journal of biological chemistry 2007;282(34):24538-46.
2007: Andras Szollosi; Myriam Nenquin; Jean-Claude Henquin
Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.
The Journal of biological chemistry 2007;282(20):14768-76.
2007: Pierre Moulin; Yves Guiot; Jean-Christophe Jonas; Jacques Rahier; Olivier Devuyst; Jean-Claude Henquin
Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla.
Journal of molecular endocrinology 2007;38(3):409-22.
2007: Andras Szollosi; Myriam Nenquin; Lydia Aguilar-Bryan; Joseph Bryan; Jean-Claude Henquin
Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.
The Journal of biological chemistry 2007;282(3):1747-56.
2006: Jean-Claude Henquin; Denis Dufrane; Myriam Nenquin
Nutrient control of insulin secretion in isolated normal human islets.
Diabetes 2006;55(12):3470-7.
2006: Patrick Stiernet; Yves Guiot; Patrick Gilon; Jean-Claude Henquin
Glucose acutely decreases pH of secretory granules in mouse pancreatic islets. Mechanisms and influence on insulin secretion.
The Journal of biological chemistry 2006;281(31):22142-51.
2006: MZ Khaldi; H Elouil; Yves Guiot; Jean-Claude Henquin; Jean-Christophe Jonas
Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E137-46.
2006: Melanie C Beauvois; Charafa Merezak; Jean-Christophe Jonas; Magalie A Ravier; Jean-Claude Henquin; Patrick Gilon
Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum.
American journal of physiology. Cell physiology 2006;290(6):C1503-11.
2006: Nobuyoshi Ishiyama; Magalie A Ravier; Jean-Claude Henquin
Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E540-9.
2006: Jean-Claude Henquin; Myriam Nenquin; Patrick Stiernet; Bo Ahren
In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells.
Diabetes 2006;55(2):441-51.
2005: Christian Boitard; Suad Efendic; Ele Ferrannini; Jean-Claude Henquin; Donald F Steiner; Erol Cerasi
A tale of two cousins: type 1 and type 2 diabetes.
Diabetes 2005;54 Suppl 2():S1-3.
2005: Magalie A Ravier; Martin Güldenagel; Anne Charollais; Asllan Gjinovci; Dorothée Caille; Goran Söhl; Claes B Wollheim; Klaus Willecke; Jean-Claude Henquin; Paolo Meda
Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
Diabetes 2005;54(6):1798-807.
2005: Denis Dufrane; Rose-Marie Goebbels; Yves Guiot; Jean-Paul Squifflet; Jean-Claude Henquin; Pierre Gianello
A simple method using a polymethylpenten chamber for isolation of human pancreatic islets.
Pancreas 2005;30(3):e51-9.
2005: H Elouil; A K Cardozo; D L Eizirik; Jean-Claude Henquin; Jean-Christophe Jonas
High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.
Diabetologia 2005;48(3):496-505.
2004: Jean-Claude Henquin
Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues.
Diabetes 2004;53 Suppl 3():S48-58.
2004: Jean-Claude Henquin; Christian Boitard; Erol Cerasi; Ele Ferrannini; Donald F Steiner; Suad Efendic
Impact of treatment on islet function in type 2 diabetes.
Diabetes 2004;53 Suppl 3():S1-5.
2004: Melanie C Beauvois; Abdelilah Arredouani; Jean-Christophe Jonas; jean-francois rolland; Frans Schuit; Jean-Claude Henquin; Patrick Gilon
Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.
The Journal of physiology 2004;559(Pt 1):141-56.
2004: Milos Zarkovic; Jean-Claude Henquin
Synchronization and entrainment of cytoplasmic Ca2+ oscillations in cell clusters prepared from single or multiple mouse pancreatic islets.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E340-7.
2004: MZ Khaldi; Yves Guiot; Patrick Gilon; Jean-Claude Henquin; Jean-Christophe Jonas
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E207-17.
2004: Myriam Nenquin; Andras Szollosi; Lydia Aguilar-Bryan; Joseph Bryan; Jean-Claude Henquin
Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.
The Journal of biological chemistry 2004;279(31):32316-24.
2004: Christian Boitard; Erol Cerasi; Suad Efendic; Jean-Claude Henquin; Donald F Steiner; Ele Ferrannini
Novel factors in the regulation of beta-cell function.
Diabetes 2004;53 Suppl 1():S1-3.
2003: Mark Van de Casteele; Benjamin Ate Kefas; Ying Cai; Harry Heimberg; Donald Scott; Jean-Claude Henquin; Daniel Pipeleers; Jean Christophe Jonas
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.
Biochemical and biophysical research communications 2003;312(4):937-44.
2003: Jean-Claude Henquin; Magalie A Ravier; Myriam Nenquin; Jean-Christophe Jonas; Patrick Gilon
Hierarchy of the beta-cell signals controlling insulin secretion.
European journal of clinical investigation 2003;33(9):742-50.
2003: Jean-Christophe Jonas; Yves Guiot; Jacques Rahier; Jean-Claude Henquin
Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP.
Diabetologia 2003;46(9):1234-44.
2002: Abdelilah Arredouani; Yves Guiot; Jean-Christophe Jonas; Lynne H Liu; Myriam Nenquin; José A Pertusa; Jacques Rahier; jean-francois rolland; Gary E Shull; Martine Stevens; Frank Wuytack; Jean-Claude Henquin; Patrick Gilon
SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.
Diabetes 2002;51(11):3245-53.
2002: Magalie A Ravier; Jean-Claude Henquin
Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets.
FEBS letters 2002;530(1-3):215-9.
2002: jean-francois rolland; Jean-Claude Henquin; Patrick Gilon
G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells.
The Journal of biological chemistry 2002;277(41):38373-80.
2002: GYSLAINE BERTRAND; Nobuyoshi Ishiyama; Myriam Nenquin; Magalie A Ravier; Jean-Claude Henquin
The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related.
The Journal of biological chemistry 2002;277(36):32883-91.
2002: Magalie A Ravier; J Sehlin; Jean-Claude Henquin
Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob/ obmice.
Diabetologia 2002;45(8):1154-63.
2002: Jose A G Pertusa; Ronit Nesher; Nurit Kaiser; Erol Cerasi; Jean-Claude Henquin; Jean-Christophe Jonas
Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes.
Diabetes 2002;51(8):2552-60.
2002: Abdelilah Arredouani; Jean-Claude Henquin; Patrick Gilon
Contribution of the endoplasmic reticulum to the glucose-induced [Ca(2+)](c) response in mouse pancreatic islets.
American journal of physiology. Endocrinology and metabolism 2002;282(5):E982-91.
2002: Lise L Kjems; Magalie A Ravier; Jean-Christophe Jonas; Jean-Claude Henquin
Do oscillations of insulin secretion occur in the absence of cytoplasmic Ca2+ oscillations in beta-cells?
Diabetes 2002;51 Suppl 1():S177-82.
2002: Patrick Gilon; Magalie A Ravier; Jean-Christophe Jonas; Jean-Claude Henquin
Control mechanisms of the oscillations of insulin secretion in vitro and in vivo.
Diabetes 2002;51 Suppl 1():S144-51.
2002: Jean-Claude Henquin; Nobuyoshi Ishiyama; Myriam Nenquin; Magalie A Ravier; Jean-Christophe Jonas
Signals and pools underlying biphasic insulin secretion.
Diabetes 2002;51 Suppl 1():S60-7.
2002: Jean-Claude Henquin; Christian Boitard; Suad Efendic; Ele Ferrannini; Donald F Steiner; Erol Cerasi
Insulin secretion: movement at all levels.
Diabetes 2002;51 Suppl 1():S1-2.
2002: jean-francois rolland; Jean-Claude Henquin; Patrick Gilon
Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells.
Diabetes 2002;51(2):376-84.
2001: Patrick Gilon; Jean-Claude Henquin
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function.
Endocrine reviews 2001;22(5):565-604.
2001: Jean-Christophe Jonas; D Ross Laybutt; Garry Steil; Nitin Trivedi; J G Pertusa; Mark Van de Casteele; Gordon C Weir; Jean-Claude Henquin
High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells.
The Journal of biological chemistry 2001;276(38):35375-81.
2001: FC Jonkers; Yves Guiot; Jacques Rahier; Jean-Claude Henquin
Tolbutamide stimulation of pancreatic beta-cells involves both cell recruitment and increase in the individual Ca(2+) response.
British journal of pharmacology 2001;133(4):575-85.
2001: FC Jonkers; Jean-Claude Henquin
Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response.
Diabetes 2001;50(3):540-50.
2001: Jean-Christophe Jonas; R Laybutt; Garry Steil; Nitin Trivedi; Gordon C Weir; Jean-Claude Henquin
Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration.
Diabetes 2001;50 Suppl 1():S137.
2001: M J Garcia-Barrado; Magalie A Ravier; jean-francois rolland; Patrick Gilon; Myriam Nenquin; Jean-Claude Henquin
Inhibition of protein synthesis sequentially impairs distinct steps of stimulus-secretion coupling in pancreatic beta cells.
Endocrinology 2001;142(1):299-307.
2000: Jean-Claude Henquin
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Diabetes 2000;49(11):1751-60.
2000: Magalie A Ravier; K Eto; FC Jonkers; Myriam Nenquin; T Kadowaki; Jean-Claude Henquin
The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout.
The Journal of biological chemistry 2000;275(3):1587-93.
2000: Jean-Claude Henquin; M Anello; Y Sato
[ATP-dependent potassium channels and insulin secretion: essential but not sufficient role].
Journées annuelles de diabétologie de l'Hôtel-Dieu 2000;():13-24.
1999: Magalie A Ravier; Patrick Gilon; Jean-Claude Henquin
Oscillations of insulin secretion can be triggered by imposed oscillations of cytoplasmic Ca2+ or metabolism in normal mouse islets.
Diabetes 1999;48(12):2374-82.
1999: FC Jonkers; J C Jonas; Patrick Gilon; Jean-Claude Henquin
Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells.
The Journal of physiology 1999;520 Pt 3():839-49.
1999: Daisy Flamez; Patrick Gilon; Karen Moens; A Van Breusegem; Dominique Delmeire; LA Scrocchi; Jean-Claude Henquin; Daniel J Drucker; Frans Schuit
Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.
Diabetes 1999;48(10):1979-86.
1999: M Anello; Patrick Gilon; Jean-Claude Henquin
Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content.
British journal of pharmacology 1999;127(8):1883-91.
1999: C Warnotte; Myriam Nenquin; Jean-Claude Henquin
Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion.
Molecular and cellular endocrinology 1999;153(1-2):147-53.
1999: Patrick Gilon; Abdelilah Arredouani; P Gailly; Jesper Gromada; Jean-Claude Henquin
Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell.
The Journal of biological chemistry 1999;274(29):20197-205.
1999: Y Sato; M Anello; Jean-Claude Henquin
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells.
Endocrinology 1999;140(5):2252-7.
1998: P Detimary; S Dejonghe; Zhidong Ling; Daniel Pipeleers; Frans Schuit; Jean-Claude Henquin
The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets.
The Journal of biological chemistry 1998;273(51):33905-8.
1998: Y Sato; Jean-Claude Henquin
The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism.
Diabetes 1998;47(11):1713-21.
1998: Jean-Christophe Jonas; Patrick Gilon; Jean-Claude Henquin
Temporal and quantitative correlations between insulin secretion and stably elevated or oscillatory cytoplasmic Ca2+ in mouse pancreatic beta-cells.
Diabetes 1998;47(8):1266-73.
1998: P Detimary; Patrick Gilon; Jean-Claude Henquin
Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets.
The Biochemical journal 1998;333 ( Pt 2)():269-74.
1998: P Mariot; Patrick Gilon; Myriam Nenquin; Jean-Claude Henquin
Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells.
Diabetes 1998;47(3):365-73.
1998: Jean-Claude Henquin
A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells.
Endocrinology 1998;139(3):993-8.
1998: Jean-Claude Henquin; J C Jonas; Patrick Gilon
Functional significance of Ca2+ oscillations in pancreatic beta cells.
Diabetes & metabolism 1998;24(1):30-6.
1998: Y Sato; Myriam Nenquin; Jean-Claude Henquin
Relative contribution of Ca2+-dependent and Ca2+-independent mechanisms to the regulation of insulin secretion by glucose.
FEBS letters 1998;421(2):115-9.
1998: Y Sato; P Mariot; P Detimary; Patrick Gilon; Jean-Claude Henquin
Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion.
British journal of pharmacology 1998;123(1):97-105.
1997: BA Reul; D J Becker; LN Ongemba; C J Bailey; Jean-Claude Henquin; Sonia M Brichard
Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate.
The Journal of endocrinology 1997;155(1):55-64.
1997: Y Miura; Jean-Claude Henquin; Patrick Gilon
Emptying of intracellular Ca2+ stores stimulates Ca2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms.
The Journal of physiology 1997;503 ( Pt 2)():387-98.
1997: BA Reul; LN Ongemba; A M Pottier; Jean-Claude Henquin; Sonia M Brichard
Insulin and insulin-like growth factor 1 antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue.
The Biochemical journal 1997;324 ( Pt 2)():605-10.
1997: P Detimary; C Xiao; Jean-Claude Henquin
Tight links between adenine and guanine nucleotide pools in mouse pancreatic islets: a study with mycophenolic acid.
The Biochemical journal 1997;324 ( Pt 2)():467-71.
1997: Patrick Gilon; J Yakel; Jesper Gromada; Y Zhu; Jean-Claude Henquin; P Rorsman
G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells.
The Journal of physiology 1997;499 ( Pt 1)():65-76.
1997: C Lambillotte; Patrick Gilon; Jean-Claude Henquin
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
The Journal of clinical investigation 1997;99(3):414-23.
1997: V Rousseau; D J Becker; LN Ongemba; J Rahier; Jean-Claude Henquin; Sonia M Brichard
Developmental and nutritional changes of ob and PPAR gamma 2 gene expression in rat white adipose tissue.
The Biochemical journal 1997;321 ( Pt 2)():451-6.
1997: Jean-Claude Henquin
Ionic and metabolic messengers in the control of insulin secretion.
The Japanese journal of physiology 1997;47 Suppl 1():S9.
1996: P Detimary; J C Jonas; Jean-Claude Henquin
Stable and diffusible pools of nucleotides in pancreatic islet cells.
Endocrinology 1996;137(11):4671-6.
1996: M J Garcia-Barrado; Patrick Gilon; Y Sato; Myriam Nenquin; Jean-Claude Henquin
No evidence for a role of reverse Na(+)-Ca2+ exchange in insulin release from mouse pancreatic islets.
The American journal of physiology 1996;271(3 Pt 1):E426-33.
1996: P Detimary; G Van den Berghe; Jean-Claude Henquin
Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets.
The Journal of biological chemistry 1996;271(34):20559-65.
1996: Y Miura; Patrick Gilon; Jean-Claude Henquin
Muscarinic stimulation increases Na+ entry in pancreatic B-cells by a mechanism other than the emptying of intracellular Ca2+ pools.
Biochemical and biophysical research communications 1996;224(1):67-73.
1996: J C Jonas; Jean-Claude Henquin
Possible involvement of a tyrosine kinase-dependent pathway in the regulation of phosphoinositide metabolism by vanadate in normal mouse islets.
The Biochemical journal 1996;315 ( Pt 1)():49-55.
1996: M J Garcia-Barrado; J C Jonas; Patrick Gilon; Jean-Claude Henquin
Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells.
European journal of pharmacology 1996;298(3):279-86.
1996: A T Ozcelikay; D J Becker; LN Ongemba; A M Pottier; Jean-Claude Henquin; Sonia M Brichard
Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate.
The American journal of physiology 1996;270(2 Pt 1):E344-52.
1996: R M Shepherd; Patrick Gilon; Jean-Claude Henquin
Ketoisocaproic acid and leucine increase cytoplasmic pH in mouse pancreatic B cells: role of cytoplasmic Ca2+ and pH-regulating exchangers.
Endocrinology 1996;137(2):677-85.
1996: D J Becker; BA Reul; A T Ozcelikay; J P Buchet; Jean-Claude Henquin; Sonia M Brichard
Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats.
Diabetologia 1996;39(1):3-11.
1995: Patrick Gilon; Jean-Claude Henquin
Distinct effects of glucose on the synchronous oscillations of insulin release and cytoplasmic Ca2+ concentration measured simultaneously in single mouse islets.
Endocrinology 1995;136(12):5725-30.
1995: Patrick Gilon; Myriam Nenquin; Jean-Claude Henquin
Muscarinic stimulation exerts both stimulatory and inhibitory effects on the concentration of cytoplasmic Ca2+ in the electrically excitable pancreatic B-cell.
The Biochemical journal 1995;311 ( Pt 1)():259-67.
1995: P Detimary; J C Jonas; Jean-Claude Henquin
Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets.
The Journal of clinical investigation 1995;96(4):1738-45.
1995: D J Becker; LN Ongemba; V Brichard; Jean-Claude Henquin; Sonia M Brichard
Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue.
FEBS letters 1995;371(3):324-8.
1995: R M Shepherd; Jean-Claude Henquin
The role of metabolism, cytoplasmic Ca2+, and pH-regulating exchangers in glucose-induced rise of cytoplasmic pH in normal mouse pancreatic islets.
The Journal of biological chemistry 1995;270(14):7915-21.
1995: J C Jonas; T D Plant; Patrick Gilon; P Detimary; Myriam Nenquin; Jean-Claude Henquin
Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets.
British journal of pharmacology 1995;114(4):872-80.
1994: Sonia M Brichard; LN Ongemba; J Girard; Jean-Claude Henquin
Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate.
Diabetologia 1994;37(11):1065-72.
1994: J C Jonas; M J Garcia-Barrado; I Angel; Jean-Claude Henquin
The imidazoline SL 84.0418 shows stereoselectivity in blocking alpha 2-adrenoceptors but not ATP-sensitive K+ channels in pancreatic B-cells.
European journal of pharmacology 1994;264(1):81-4.
1994: Patrick Gilon; J C Jonas; Jean-Claude Henquin
Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets.
Diabetologia 1994;37(10):1007-14.
1994: G Drews; A Debuyser; Jean-Claude Henquin
Significance of membrane repolarization and cyclic AMP changes in mouse pancreatic B-cells for the inhibition of insulin release by galanin.
Molecular and cellular endocrinology 1994;105(1):97-102.
1994: Jean-Claude Henquin; F Carton; LN Ongemba; D J Becker
Improvement of mild hypoinsulinaemic diabetes in the rat by low non-toxic doses of vanadate.
The Journal of endocrinology 1994;142(3):555-61.
1994: D J Becker; L N Ongemba; Jean-Claude Henquin
Comparison of the effects of various vanadium salts on glucose homeostasis in streptozotocin-diabetic rats.
European journal of pharmacology 1994;260(2-3):169-75.
1994: Z Y Gao; Patrick Gilon; Jean-Claude Henquin
The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse.
Endocrinology 1994;135(1):191-9.
1994: C Warnotte; Patrick Gilon; Myriam Nenquin; Jean-Claude Henquin
Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells.
Diabetes 1994;43(5):703-11.
1994: J C Jonas; T D Plant; I Angel; S Z Langer; Jean-Claude Henquin
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
European journal of pharmacology 1994;254(1-2):27-33.
1994: Jean-Claude Henquin; M Gembal; P Detimary; Z Y Gao; C Warnotte; Patrick Gilon
Multisite control of insulin release by glucose.
Diabète & métabolisme 1994;20(2):132-7.
1994: P Detimary; Patrick Gilon; Myriam Nenquin; Jean-Claude Henquin
Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells.
The Biochemical journal 1994;297 ( Pt 3)():455-61.
1994: Jean-Claude Henquin; P Detimary; M Gembal; J C Jonas; R M Shepherd; C Warnotte; Patrick Gilon
[Biophysical aspects of control of insulin secretion].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1994;():21-32.
1993: Patrick Gilon; R M Shepherd; Jean-Claude Henquin
Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.
The Journal of biological chemistry 1993;268(30):22265-8.
1993: M Gembal; P Detimary; Patrick Gilon; Z Y Gao; Jean-Claude Henquin
Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.
The Journal of clinical investigation 1993;91(3):871-80.
1993: G Drews; P Detimary; Jean-Claude Henquin
Non-additivity of adrenaline and galanin effects on 86Rb efflux and membrane potential in mouse B-cells suggests sharing of common targets.
Biochimica et biophysica acta 1993;1175(2):214-8.
1992: Patrick Gilon; Jean-Claude Henquin
Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell.
The Journal of biological chemistry 1992;267(29):20713-20.
1992: Jean-Claude Henquin
The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?
Diabetologia 1992;35(10):907-12.
1992: J C Jonas; T D Plant; Jean-Claude Henquin
Imidazoline antagonists of alpha 2-adrenoceptors increase insulin release in vitro by inhibiting ATP-sensitive K+ channels in pancreatic beta-cells.
British journal of pharmacology 1992;107(1):8-14.
1992: Sonia M Brichard; LN Ongemba; Jean-Claude Henquin
Oral vanadate decreases muscle insulin resistance in obese fa/fa rats.
Diabetologia 1992;35(6):522-7.
1992: M Gembal; Patrick Gilon; Jean-Claude Henquin
Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells.
The Journal of clinical investigation 1992;89(4):1288-95.
1992: Z Y Gao; M Gérard; Jean-Claude Henquin
Glucose- and concentration-dependence of vasopressin-induced hormone release by mouse pancreatic islets.
Regulatory peptides 1992;38(1):89-98.
1991: A Q Zhang; Z Y Gao; Patrick Gilon; Myriam Nenquin; G Drews; Jean-Claude Henquin
Vanadate stimulation of insulin release in normal mouse islets.
The Journal of biological chemistry 1991;266(32):21649-56.
1991: Sonia M Brichard; LN Ongemba; J Kolanowski; Jean-Claude Henquin
The influence of vanadate on insulin counter-regulatory hormones in obese fa/fa rats.
The Journal of endocrinology 1991;131(2):185-91.
1991: Patrick Gilon; GYSLAINE BERTRAND; M M Loubatières-Mariani; C Remacle; Jean-Claude Henquin
The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas.
Endocrinology 1991;129(5):2521-9.
1991: T D Plant; J C Jonas; Jean-Claude Henquin
Clonidine inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells.
British journal of pharmacology 1991;104(2):385-90.
1991: A Debuyser; G Drews; Jean-Claude Henquin
Adrenaline inhibition of insulin release: role of the repolarization of the B cell membrane.
Pflügers Archiv : European journal of physiology 1991;419(2):131-7.
1991: A Debuyser; G Drews; Jean-Claude Henquin
The influence of temperature on the effects of acetylcholine and adrenaline on the membrane potential and 86Rb efflux in mouse pancreatic B-cells.
Experimental physiology 1991;76(4):553-9.
1991: A Debuyser; G Drews; Jean-Claude Henquin
Adrenaline inhibition of insulin release: role of cyclic AMP.
Molecular and cellular endocrinology 1991;78(3):179-86.
1991: Z Y Gao; G Drews; Jean-Claude Henquin
Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets.
The Biochemical journal 1991;276 ( Pt 1)():169-74.
1991: M P Hermans; W Schmeer; M Gérard; Jean-Claude Henquin
Effects of chloride deficiency on the pancreatic B-cell response to acetylcholine.
Biochimica et biophysica acta 1991;1092(2):205-10.
1990: Z Y Gao; G Drews; Myriam Nenquin; T D Plant; Jean-Claude Henquin
Mechanisms of the stimulation of insulin release by arginine-vasopressin in normal mouse islets.
The Journal of biological chemistry 1990;265(26):15724-30.
1990: M G Garrino; Jean-Claude Henquin
B cell adrenoceptors and sulphonylurea-induced insulin release in mouse islets.
Diabetologia 1990;33(3):145-7.
1990: G Drews; A Debuyser; Myriam Nenquin; Jean-Claude Henquin
Galanin and epinephrine act on distinct receptors to inhibit insulin release by the same mechanisms including an increase in K+ permeability of the B-cell membrane.
Endocrinology 1990;126(3):1646-53.
1990: GYSLAINE BERTRAND; Jean-Claude Henquin
The influence of sodium omission on alpha 2-adrenergic inhibition of insulin release by mouse islets.
Life sciences 1990;47(4):299-305.
1989: P Petit; GYSLAINE BERTRAND; W Schmeer; Jean-Claude Henquin
Effects of extracellular adenine nucleotides on the electrical, ionic and secretory events in mouse pancreatic beta-cells.
British journal of pharmacology 1989;98(3):875-82.
1989: Sonia M Brichard; A M Pottier; Jean-Claude Henquin
Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats.
Endocrinology 1989;125(5):2510-6.
1989: M G Garrino; T D Plant; Jean-Claude Henquin
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
British journal of pharmacology 1989;98(3):957-65.
1989: GYSLAINE BERTRAND; P Petit; M Bozem; Jean-Claude Henquin
Membrane and intracellular effects of adenosine in mouse pancreatic beta-cells.
The American journal of physiology 1989;257(4 Pt 1):E473-8.
1989: GYSLAINE BERTRAND; Myriam Nenquin; Jean-Claude Henquin
Comparison of the inhibition of insulin release by activation of adenosine and alpha 2-adrenergic receptors in rat beta-cells.
The Biochemical journal 1989;259(1):223-8.
1989: T D Plant; M G Garrino; Jean-Claude Henquin
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S152-3.
1988: M Bozem; Jean-Claude Henquin
Glucose modulation of spike activity independently from changes in slow waves of membrane potential in mouse B-cells.
Pflügers Archiv : European journal of physiology 1988;413(2):147-52.
1988: W Okitolonda; Sonia M Brichard; A M Pottier; Jean-Claude Henquin
Influence of low- and high-protein diets on glucose homeostasis in the rat.
The British journal of nutrition 1988;60(3):509-16.
1988: Jean-Claude Henquin
ATP-sensitive K+ channels may control glucose-induced electrical activity in pancreatic B-cells.
Biochemical and biophysical research communications 1988;156(2):769-75.
1988: Sonia M Brichard; W Okitolonda; Jean-Claude Henquin
Long term improvement of glucose homeostasis by vanadate treatment in diabetic rats.
Endocrinology 1988;123(4):2048-53.
1988: M C Garcia; M P Hermans; Jean-Claude Henquin
Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets.
The Biochemical journal 1988;254(1):211-8.
1988: Jean-Claude Henquin; Myriam Nenquin
The muscarinic receptor subtype in mouse pancreatic B-cells.
FEBS letters 1988;236(1):89-92.
1988: Jean-Claude Henquin; M C Garcia; M Bozem; M P Hermans; Myriam Nenquin
Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx.
Endocrinology 1988;122(5):2134-42.
1988: R de Miguel; T Tamagawa; W Schmeer; Myriam Nenquin; Jean-Claude Henquin
Effects of acute sodium omission on insulin release, ionic flux and membrane potential in mouse pancreatic B-cells.
Biochimica et biophysica acta 1988;969(2):198-207.
1988: M G Garrino; Jean-Claude Henquin
Highly potent and stereoselective effects of the benzoic acid derivative AZ-DF 265 on pancreatic beta-cells.
British journal of pharmacology 1988;93(1):61-8.
1987: W Okitolonda; Sonia M Brichard; Jean-Claude Henquin
Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat.
Diabetologia 1987;30(12):946-51.
1987: M Bozem; M G Garrino; Jean-Claude Henquin
Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells.
Pflügers Archiv : European journal of physiology 1987;410(4-5):457-63.
1987: Jean-Claude Henquin; M G Garrino; Myriam Nenquin
Stimulation of insulin release by benzoic acid derivatives related to the non-sulphonylurea moiety of glibenclamide: structural requirements and cellular mechanisms.
European journal of pharmacology 1987;141(2):243-51.
1987: M Bozem; Myriam Nenquin; Jean-Claude Henquin
The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester.
Endocrinology 1987;121(3):1025-33.
1987: Jean-Claude Henquin; M Bozem; W Schmeer; Myriam Nenquin
Distinct mechanisms for two amplification systems of insulin release.
The Biochemical journal 1987;246(2):393-9.
1987: M P Hermans; W Schmeer; Jean-Claude Henquin
The permissive effect of glucose, tolbutamide and high K+ on arginine stimulation of insulin release in isolated mouse islets.
Diabetologia 1987;30(8):659-65.
1987: M P Hermans; W Schmeer; Jean-Claude Henquin
Modulation of the effect of acetylcholine on insulin release by the membrane potential of B cells.
Endocrinology 1987;120(5):1765-73.
1987: Jean-Claude Henquin
Regulation of insulin release by ionic and electrical events in B cells.
Hormone research 1987;27(3):168-78.
1986: W Okitolonda; A M Pottier; Jean-Claude Henquin
Glucose homeostasis in rats treated acutely and chronically with quinine.
European journal of pharmacology 1986;132(2-3):179-85.
1986: M P Hermans; M Gérard; Jean-Claude Henquin
Role of the decrease in ionized calcium in the inhibition of insulin release by chloride-free solutions.
Biochimica et biophysica acta 1986;889(2):262-5.
1986: M G Garrino; H P Meissner; Jean-Claude Henquin
The non-sulfonylurea moiety of gliquidone mimics the effects of the parent molecule on pancreatic B-cells.
European journal of pharmacology 1986;124(3):309-16.
1986: Jean-Claude Henquin; M G Garrino; Myriam Nenquin; G Paolisso; M Hermans
Pharmacological control of 86Rb efflux from mouse pancreatic islets.
Advances in experimental medicine and biology 1986;211():83-93.
1985: Jean-Claude Henquin; W Schmeer; Myriam Nenquin; H P Meissner
Effects of a calcium channel agonist on the electrical, ionic and secretory events in mouse pancreatic B-cells.
Biochemical and biophysical research communications 1985;131(2):980-6.
1985: M G Garrino; W Schmeer; Myriam Nenquin; H P Meissner; Jean-Claude Henquin
Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide.
Diabetologia 1985;28(9):697-703.
1985: Jean-Claude Henquin; R de Miguel; M G Garrino; M Hermans; Myriam Nenquin
Nutrient insulin secretagogues decrease 45Ca2+ efflux from islet cells by a mechanism other than the inhibition of the Na+-Ca2+ countertransport.
FEBS letters 1985;187(1):177-81.
1985: G Paolisso; Myriam Nenquin; W Schmeer; F Mathot; H P Meissner; Jean-Claude Henquin
Sparteine increases insulin release by decreasing the K+ permeability of the B-cell membrane.
Biochemical pharmacology 1985;34(13):2355-61.
1984: Myriam Nenquin; P Awouters; F Mathot; Jean-Claude Henquin
Distinct effects of acetylcholine and glucose on 45calcium and 86rubidium efflux from mouse pancreatic islets.
FEBS letters 1984;176(2):457-61.
1984: Jean-Claude Henquin; W Schmeer; Myriam Nenquin; H P Meissner
Forskolin suppresses the slow cyclic variations of glucose-induced electrical activity in pancreatic B cells.
Biochemical and biophysical research communications 1984;120(3):797-803.
1983: Jean-Claude Henquin; W Schmeer; H P Meissner
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells.
Endocrinology 1983;112(6):2218-20.
1982: S Charles; T Tamagawa; Jean-Claude Henquin
A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids.
The Biochemical journal 1982;208(2):301-8.
1982: Jean-Claude Henquin; S Charles; Myriam Nenquin; F Mathot; T Tamagawa
Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli.
Diabetes 1982;31(9):776-83.
1982: Jean-Claude Henquin; H P Meissner; W Schmeer
Cyclic variations of glucose-induced electrical activity in pancreatic B cells.
Pflügers Archiv : European journal of physiology 1982;393(4):322-7.