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Houman Ashrafian

Research Profile

Disorders

Anatomy

Physiology

Chemicals & Drugs

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Heart Valve Prosthesis

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TOP 3
Hussain Contractor; Colin Cunnington; Jonathan Diesch; Rebekka Jensen; Cedric Manlhiot; Julian O M Ormerod; Andrew Redington; Michael R Schmidt; Nicolaj Brejnholt Støttrup; Houman Ashrafian; Hans Erik Bøtker; Rajesh K Kharbanda
Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.
Michael S Dodd; Hugh Watkins; Houman Ashrafian; Vicky Ball; Rosalind Bray; Kieran Clarke; Damian J Tyler
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
Michael s Dodd; Lisa C Heather; Lydia M Le Page; Marie A Schroeder; Anne-Marie Seymour; Houman Ashrafian; Helen J Atherton; Daniel R Ball; Kieran Clarke; Hugh Watkins; Damian J Tyler
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

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2013: Hussain Contractor; Colin Cunnington; Jonathan Diesch; Rebekka Jensen; Cedric Manlhiot; Julian O M Ormerod; Andrew Redington; Michael R Schmidt; Nicolaj Brejnholt Støttrup; Houman Ashrafian; Hans Erik Bøtker; Rajesh K Kharbanda
Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.
Basic research in cardiology 2013;108(3):343.
2013: Michael S Dodd; Hugh Watkins; Houman Ashrafian; Vicky Ball; Rosalind Bray; Kieran Clarke; Damian J Tyler
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2013;15():19.
2012: Michael s Dodd; Lisa C Heather; Lydia M Le Page; Marie A Schroeder; Anne-Marie Seymour; Houman Ashrafian; Helen J Atherton; Daniel R Ball; Kieran Clarke; Hugh Watkins; Damian J Tyler
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.
Cardiovascular research 2012;95(1):69-76.
2012: Sandra Marisa Oliveira; Katalin Pinter; Houman Ashrafian; Mohamed Bellahcene; David Carling; Barbara Casadei; Joanna K Davies; Ying Ge; Henrik Isackson; Raquel Sancho Solis; Jeffery W Walker; Hugh Watkins; Arash Yavari; Yin-Hua Zhang; Charles Redwood
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
Circulation research 2012;110(9):1192-201.
2011: Lindsay M Edwards; Houman Ashrafian; Bernard Korzeniewski
In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration.
Molecular bioSystems 2011;7(12):3335-42.
2011: Houman Ashrafian; William J McKenna; Hugh Watkins
Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy.
Circulation research 2011;109(1):86-96.
2011: Vanash M Patel; Ara Darzi; Sejal Jiwan; Jeremy K Nicholson; Kamran Ahmed; Sonal Arora; Houman Ashrafian; Thanos Athanasiou
How has healthcare research performance been assessed?: a systematic review.
Journal of the Royal Society of Medicine 2011;104(6):251-61.
2011: Houman Ashrafian; Thanos Athanasiou; J V Li; Marco Bueter; Kamran Ahmed; K Nagpal; Elaine Holmes; Ara Darzi; Stephen R Bloom
Diabetes resolution and hyperinsulinaemia after metabolic Roux-en-Y gastric bypass.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2011;12(5):e257-72.
2011: Hugh Watkins; Houman Ashrafian; Charles Redwood
Inherited cardiomyopathies.
The New England journal of medicine 2011;364(17):1643-56.
2011: Julian O M Ormerod; Houman Ashrafian; Abdul R Maher; Sayqa Arif; Violetta Steeples; Gustav V R Born; Stuart Egginton; Martin Feelisch; Hugh Watkins; Michael P Frenneaux
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.
Cardiovascular research 2011;89(3):560-5.
2011: Houman Ashrafian; Stefan Neubauer
Metabolic modulation in heart failure: high time for a definitive clinical trial.
Heart (British Cardiac Society) 2011;97(4):267-8.
2011: Neil J Howell; Houman Ashrafian; Nigel E Drury; Aaron M Ranasinghe; Hussain Contractor; Henrik Isackson; Melanie Calvert; Lynne K Williams; Nick Freemantle; David W Quinn; David Green; Michael Frenneaux; Robert S Bonser; Jorge G Mascaro; Timothy R Graham; Stephen J Rooney; Ian C Wilson; Domenico Pagano
Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial.
Circulation 2011;123(2):170-7.
2010: Houman Ashrafian; Marco Bueter; Kamran Ahmed; A Suliman; Stephen R Bloom; Ara Darzi; Thanos Athanasiou
Metabolic surgery: an evolution through bariatric animal models.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2010;11(12):907-20.
2010: Khalid Abozguia; Perry Elliott; William McKenna; Thanh Trung Phan; Ganesh Nallur-Shivu; Ibrar Ahmed; Abdul R Maher; Kulvinder Kaur; Jenny Taylor; Anke Henning; Houman Ashrafian; Hugh Watkins; Michael Frenneaux
Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.
Circulation 2010;122(16):1562-9.
2010: Linda O'Flaherty; Julie Adam; Lisa C Heather; Alexander V Zhdanov; Yuen-Li Chung; Melroy X Miranda; Joanne Croft; Simon Olpin; Kieran Clarke; Christopher W Pugh; John Griffiths; Dmitri Papkovsky; Houman Ashrafian; Peter J Ratcliffe; Patrick J Pollard
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
Human molecular genetics 2010;19(19):3844-51.
2010: Mohammad Nassimizadeh; Houman Ashrafian; Nigel E Drury; Neil J Howell; Janet Digby; Domenico Pagano; Michael P Frenneaux; Gustav V R Born
Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2010;7(3):213-5.
2010: Houman Ashrafian; Louise Docherty; Vincenzo Leo; Christopher Towlson; Monica Neilan; Violetta Steeples; Craig A Lygate; Tertius A Hough; Stuart Townsend; Debbie Williams; Sara Wells; Dominic Norris; Sarah Glyn-Jones; John Land; Ivana Barbaric; Zuzanne Lalanne; Paul Denny; Dorota Szumska; Shoumo Bhattacharya; Julian L Griffin; Iain Hargreaves; Narcis Fernandez-Fuentes; Michael Cheeseman; Hugh Watkins; T Neil Dear
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
PLoS genetics 2010;6(6):e1001000.
2009: Kamran Ahmed; Houman Ashrafian; George B Hanna; Ara Darzi; Thanos Athanasiou
Assessment of specialists in cardiovascular practice.
Nature reviews. Cardiology 2009;6(10):659-67.
2009: Houman Ashrafian; Christopher Rao; Ara Darzi; Thanos Athanasiou
Benchmarking in surgical research.
Lancet 2009;374(9695):1045-7.
2009: Thanh T Phan; Khalid Abozguia; Ganesh Nallur Shivu; Gnanadevan Mahadevan; Ibrar Ahmed; Lynne Williams; Girish Dwivedi; Kiran Patel; Paul Steendijk; Houman Ashrafian; Anke Henning; Michael Frenneaux
Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.
Journal of the American College of Cardiology 2009;54(5):402-9.
2009: Houman Ashrafian; Carel W le Roux
Metabolic surgery and gut hormones - a review of bariatric entero-humoral modulation.
Physiology & behavior 2009;97(5):620-31.
2009: Sonal Arora; Houman Ashrafian; Elliott D Smock; Philip Ng
Total laparoscopic repair of sigmoid foreign body perforation.
Journal of laparoendoscopic & advanced surgical techniques. Part A 2009;19(3):401-3.
2009: Houman Ashrafian; Stefan Neubauer
Metabolomic profiling of cardiac substrate utilization: fanning the flames of systems biology?
Circulation 2009;119(13):1700-2.
2009: David H Perlman; Selena M Bauer; Houman Ashrafian; Nathan S Bryan; Maria F Garcia-Saura; Chee C Lim; Bernadette O Fernandez; Giuseppe Infusini; Mark E McComb; Catherine E Costello; Martin Feelisch
Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.
Circulation research 2009;104(6):796-804.
2009: Houman Ashrafian; Thanos Athanasiou
Extracorporeal life support for severe drug-induced cardiotoxicity: a promising therapeutic choice.
Critical care (London, England) 2009;13(5):187.
2008: Martin Feelisch; Bernadette O Fernandez; Nathan S Bryan; Maria Francisca Garcia-Saura; Selena Bauer; David R Whitlock; Peter C Ford; David R Janero; Juan Rodriguez; Houman Ashrafian
Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems.
The Journal of biological chemistry 2008;283(49):33927-34.
2008: Houman Ashrafian; Hugh Watkins
Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?
Heart (British Cardiac Society) 2008;94(10):1251-3.
2008: Hugh Watkins; Houman Ashrafian; W J McKenna
The genetics of hypertrophic cardiomyopathy: Teare redux.
Heart (British Cardiac Society) 2008;94(10):1264-8.
2008: Julian O M Ormerod; Houman Ashrafian; Michael P Frenneaux
Impaired energetics in heart failure - a new therapeutic target.
Pharmacology & therapeutics 2008;119(3):264-74.
2008: Eric Lim; Ayyaz Ali; Panagiotis Theodorou; Ines Sousa; Houman Ashrafian; Themis Chamageorgakis; Alison Duncan; Michael Henein; PETER DIGGLE; John Pepper
Longitudinal study of the profile and predictors of left ventricular mass regression after stentless aortic valve replacement.
The Annals of thoracic surgery 2008;85(6):2026-9.
2008: Houman Ashrafian
A simple "bedside" method for calculating the risks of thoracic aortic aneurysms.
Annals of vascular surgery 2008;22(3):496.
2008: RP Vincent; Houman Ashrafian; Carel W le Roux
Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity.
Nature clinical practice. Gastroenterology & hepatology 2008;5(5):268-77.
2008: Houman Ashrafian; Lynne Williams; Michael P Frenneaux
The pathophysiology of heart failure: a tale of two old paradigms revisited.
Clinical medicine (London, England) 2008;8(2):192-7.
2008: Houman Ashrafian
Recovery from gut flora sepsis in the Ancient World.
The American journal of gastroenterology 2008;103(3):515.
2008: Abdul R Maher; Alexandra B Milsom; Prasad Gunaruwan; Khalid Abozguia; Ibrar Ahmed; Rebekah A Weaver; Philip Thomas; Houman Ashrafian; Gustav V R Born; Philip E James; Michael P Frenneaux
Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.
Circulation 2008;117(5):670-7.
2008: RAJESH AGGARWAL; Luke Hodgson; Christopher Rao; Houman Ashrafian; Andre Chow; Emmanouil Zacharakis; Thanos Athanasiou; Ara Darzi; Desmond Johnston
Surgical management of morbid obesity.
British journal of hospital medicine (London, England : 2005) 2008;69(2):95-100.
2007: Houman Ashrafian; Michael P Frenneaux; Lionel Henry Opie
Metabolic mechanisms in heart failure.
Circulation 2007;116(4):434-48.
2007: Houman Ashrafian; Victor Tsang; Martin Kostolny
Rare presentation of subclavian artery isolation in a neonate with a family history of aortic arch anomalies.
The Annals of thoracic surgery 2007;83(6):2226-8.
2007: Gyorgy Andreka; Marton Vertesaljai; Gergely Szánthó; Gusztav Font; Zsolt Piroth; Géza Fontos; Eszter D Juhasz; Laszlo Szekely; Zsolt László Szelid; Mark S Turner; Houman Ashrafian; Michael P Frenneaux; Peter Andreka
Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs.
Heart (British Cardiac Society) 2007;93(6):749-52.
2007: Houman Ashrafian; Hugh Watkins
Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype.
Journal of the American College of Cardiology 2007;49(12):1251-64.
2007: Houman Ashrafian
Anatomically specific clinical examination of the carotid arterial tree.
Anatomical science international 2007;82(1):16-23.
2007: Pedro Jose Lopez; Houman Ashrafian; Simon A Clarke; Helen Johnson; Edward M Kiely
Early experience with the antegrade colonic enema stopper to reduce stomal stenosis.
Journal of pediatric surgery 2007;42(3):522-4.
2007: Houman Ashrafian; Michael P Frenneaux
Metabolic modulation in heart failure: the coming of age.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2007;21(1):5-7.
2007: Houman Ashrafian; John D Horowitz; Michael P Frenneaux
Perhexiline.
Cardiovascular drug reviews 2007;25(1):76-97.
2007: Houman Ashrafian; Mark J Mason; Andrew G Mitchell
Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2007;9(1):50-4.
2007: Houman Ashrafian; Tiong Keng Lim; Roxy Senior
Carotid ultrasound imaging: an effective technique for detecting early atherosclerosis-vascular screening for cardiovascular disease has come of age.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2007;20(1):1-3.
2007: Houman Ashrafian; Richard G Bogle
Antimicrobial prophylaxis for endocarditis: emotion or science?
Heart (British Cardiac Society) 2007;93(1):5-6.
2006: Houman Ashrafian
The Coanda effect and preferential right atrial streaming.
Chest 2006;130(1):300.
2006: Houman Ashrafian
Three saints and critical limb ischemia.
Annals of vascular surgery 2006;20(4):553-4.
2006: Houman Ashrafian
Auscultatory bedside tests for thoracic aortic disease.
International journal of cardiology 2006;108(1):111.
2006: Houman Ashrafian
Pulsatile pseudo-proptosis, aortic regurgitation and 31 eponyms.
International journal of cardiology 2006;107(3):421-3.
2006: Houman Ashrafian; Girish Dwivedi; Roxy Senior
Assessing myocardial perfusion after myocardial infarction.
PLoS medicine 2006;3(3):e131.
2006: Houman Ashrafian
Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis.
Lancet 2006;367(9510):618-21.
2006: Tiong Keng Lim; Houman Ashrafian; Girish Dwivedi; Paul O Collinson; Roxy Senior
Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure.
European journal of heart failure 2006;8(1):38-45.
2005: Leong Lee; Ross Campbell; Michaela Scheuermann-Freestone; Rachel Taylor; Prasad Gunaruwan; Lynne Williams; Houman Ashrafian; John Horowitz; Alan G Fraser; Kieran Clarke; Michael Frenneaux
Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment.
Circulation 2005;112(21):3280-8.
2005: Houman Ashrafian; Andonis G Violaris
Beta-blocker therapy of cardiovascular diseases in patients with bronchial asthma or COPD: the pro viewpoint.
Primary care respiratory journal : journal of the General Practice Airways Group 2005;14(5):236-41.
2005: Roxy Senior; Houman Ashrafian
Detecting acute coronary syndrome in the emergency department: the answer is in seeing the heart: why look further?
European heart journal 2005;26(16):1573-5.
2005: Houman Ashrafian
Hereditary angioedema in a martial arts family.
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2005;15(4):277-8.
2005: Eric Lim; Ayyaz Ali; Zain Khalpey; Houman Ashrafian; Christopher Jackson; Ziad A Ali; Themis Chamageorgakis; Francis Wells; John Pepper; Anthony DeSouza; Neil Moat
A validated simple model to predict coexistent coronary disease in patients undergoing mitral valve surgery.
The Journal of thoracic and cardiovascular surgery 2005;129(6):1318-21.
2005: Houman Ashrafian; Thanos Athanasiou; John Yap; Anthony DeSouza
Two-chamber intracardiac mesothelioma.
Asian cardiovascular & thoracic annals 2005;13(2):184-6.
2005: Houman Ashrafian; Pankaj Kumar; Pradid K Sarkar; Anthony DeSouza
Delayed penetrating intrathoracic injury from multiple rib fractures.
The Journal of trauma 2005;58(4):858-9.
2005: Roxy Senior; Houman Ashrafian
Screening for isolated diastolic dysfunction--a bridge too far?
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 2005;6(2):79-82.
2005: Houman Ashrafian
Familial proptosis and obesity in the Ptolemies.
Journal of the Royal Society of Medicine 2005;98(2):85-6.
2005: Ayyaz Ali; Pankaj Kumar; Thanos Athanasiou; James C Halstead; Houman Ashrafian; Ziad A Ali; Sanjay Kumar; Panagiotis Theodorou; John R Pepper
Is routine use of stentless aortic prostheses justified in an elderly (aged > or =75 years) population?
The Journal of heart valve disease 2005;14(1):64-70; discussion 70-1.
2004: Thanos Athanasiou; Pankaj Kumar; Houman Ashrafian; Sujit Nair; Alex Charitou; Rex D Stanbridge
Aortic valve replacement in a patient with Takayasu's disease without cross-clamping the calcified ascending aorta.
Asian cardiovascular & thoracic annals 2004;12(4):376-8.
2004: Lok B Yap; Dev Mukerjee; Peter M Timms; Houman Ashrafian; John G Coghlan
Natriuretic peptides, respiratory disease, and the right heart.
Chest 2004;126(4):1330-6.
2004: Maha T Barakat; Houman Ashrafian; Jeannie F Todd; Karim Meeran; Graham R Williams
Severe hypercalcaemia from secretion of parathyroid hormone-related peptide.
The lancet oncology 2004;5(10):633-5.
2004: Lok B Yap; Houman Ashrafian; Dev Mukerjee; John G Coghlan; Peter M Timms
The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension.
Clinical biochemistry 2004;37(10):847-56.
2004: Houman Ashrafian
The death of Alexander the Great--a spinal twist of fate.
Journal of the history of the neurosciences 2004;13(2):138-42.
2004: Houman Ashrafian; Richard G Bogle
Sensitizing the insensitive.
Clinical nephrology 2004;61(6):440-3.
2004: Maha T Barakat; Houman Ashrafian; Jeannie F Todd; Joseph J Boyle; John A Lynn; Graham R Williams
Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(4):977-80.
2004: Houman Ashrafian; Richard G Bogle; Stuart D Rosen; Michael Henein; Timothy W Evans
Portable echocardiography.
BMJ (Clinical research ed.) 2004;328(7435):300-1.
2004: Thanos Athanasiou; Houman Ashrafian; Brian Glenville; Roberto Casula
Coronary artery bypass with the use of a magnetic distal anastomotic device: surgical technique and preliminary experience.
The heart surgery forum 2004;7(6):356-9.
2003: Houman Ashrafian
Sudden death in young athletes.
The New England journal of medicine 2003;349(25):2464-5; author reply 2464-5.
2003: Houman Ashrafian
Hepcidin: the missing link between hemochromatosis and infections.
Infection and immunity 2003;71(12):6693-700.
2003: Houman Ashrafian; Pankaj Kumar; Thanos Athanasiou; Rex D Stanbridge
Minimally invasive off-pump pulmonary embolectomy.
Cardiovascular surgery (London, England) 2003;11(6):471-3.
2003: Houman Ashrafian
Human thermostat.
Lancet 2003;362(9397):1767.
2003: Roberto Casula; Pankaj Kumar; Houman Ashrafian; Thanos Athanasiou
Evolving techniques for endoscopic radial artery harvesting.
Cardiovascular surgery (London, England) 2003;11(5):425-7.
2003: Ayyaz Ali; Eric Lim; James C Halstead; Houman Ashrafian; Ziad A Ali; Zain Khalpey; Panagiotis Theodorou; Themis Chamageorgakis; Pankaj Kumar; Christopher Jackson; John Pepper
Porcine or human stentless valves for aortic valve replacement? Results of a 10-year comparative study.
The Journal of heart valve disease 2003;12(4):430-5; discussion 435.
2003: Houman Ashrafian; Charles Redwood; Edward Blair; Hugh Watkins
Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.
Trends in genetics : TIG 2003;19(5):263-8.
2002: Houman Ashrafian; L Swan
The mechanism of formation of pulmonary arteriovenous malformations associated with the classic Glenn shunt (superior cavopulmonary anastomosis).
Heart (British Cardiac Society) 2002;88(6):639.
2002: Lorna Swan; Houman Ashrafian; Michael A Gatzoulis
Repair of coarctation: a higher goal?
Lancet 2002;359(9310):977-8.
2002: Houman Ashrafian
Cardiac energetics in congestive heart failure.
Circulation 2002;105(6):e44-5.
2002: Houman Ashrafian; Simon D Taylor-Robinson; John Calam; Raymond J Playford
Once you start, you can't stop.
Lancet 2002;359(9302):226.
2001: Edward Blair; Charles Redwood; Houman Ashrafian; M Oliveira; John Broxholme; B Kerr; A Salmon; Ingegerd Ostman-Smith; Hugh Watkins
Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
Human molecular genetics 2001;10(11):1215-20.