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Paula Henthorn

Research Profile

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TOP 3
Meryl P Littman; Michael G Raducha; Claire A Wiley; Paula S Henthorn
Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs.
John C Fyfe; Richa Agarwala; Rabá A Al-Tamimi; Junlong Liu; Alejandro A Schäffer; Paula S Henthorn
A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.
Douglas R Kennedy; Brian J Hartnett; Jeffrey S Kennedy; William Vernau; Peter F Moore; Thomas M O'Malley; Linda C Burkly; Paula S Henthorn; Peter J Felsburg
Ex vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency and the development of a thymic T cell lymphoma.

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All Publications

2013: Meryl P Littman; Michael G Raducha; Claire A Wiley; Paula S Henthorn
Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs.
Mammalian genome : official journal of the International Mammalian Genome Society 2013;24(3-4):119-26.
2011: John C Fyfe; Richa Agarwala; Rabá A Al-Tamimi; Junlong Liu; Alejandro A Schäffer; Paula S Henthorn
A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.
Neurogenetics 2011;12(3):223-32.
2011: Douglas R Kennedy; Brian J Hartnett; Jeffrey S Kennedy; William Vernau; Peter F Moore; Thomas M O'Malley; Linda C Burkly; Paula S Henthorn; Peter J Felsburg
Ex vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency and the development of a thymic T cell lymphoma.
Veterinary immunology and immunopathology 2011;142(1-2):36-48.
2010: John C Fyfe; Raba' A Al-Tamimi; Rudy J Castellani; Diana Rosenstein; Daniel Goldowitz; Paula S Henthorn
Inherited neuroaxonal dystrophy in dogs causing lethal, fetal-onset motor system dysfunction and cerebellar hypoplasia.
The Journal of comparative neurology 2010;518(18):3771-84.
2009: Douglas R Kennedy; Kyle McLellan; Peter F Moore; Paula S Henthorn; Peter J Felsburg
Effect of ex vivo culture of CD34+ bone marrow cells on immune reconstitution of XSCID dogs following allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(6):662-70.
2009: Danika L Bannasch; Paula S Henthorn
Changing paradigms in diagnosis of inherited defects associated with urolithiasis.
The Veterinary clinics of North America. Small animal practice 2009;39(1):111-25.
2008: Petra Werner; Michael G Raducha; Ulana Prociuk; Meg M Sleeper; Thomas J Van Winkle; Paula S Henthorn
A novel locus for dilated cardiomyopathy maps to canine chromosome 8.
Genomics 2008;91(6):517-21.
2007: William Vernau; Brian J Hartnett; Douglas R Kennedy; Peter F Moore; Paula S Henthorn; Kenneth I Weinberg; Peter J Felsburg
T cell repertoire development in XSCID dogs following nonconditioned allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(9):1005-15.
2007: Steven E Suter; Terry A Gouthro; Thomas M O'Malley; Brian J Hartnett; Peter A McSweeney; Peter F Moore; Peter J Felsburg; Mark E Haskins; Paula S Henthorn
Marking of peripheral T-lymphocytes by retroviral transduction and transplantation of CD34+ cells in a canine X-linked severe combined immunodeficiency model.
Veterinary immunology and immunopathology 2007;117(3-4):183-96.
2007: John C Fyfe; Rebeccah Kurzhals; Michelle G Hawkins; Ping Wang; Naoya Yuhki; Urs Giger; Thomas J Van Winkle; Mark E Haskins; Donald F Patterson; Paula S Henthorn
A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest cats.
Molecular genetics and metabolism 2007;90(4):383-92.
2006: Mathew P Swerdlow; Douglas R Kennedy; Jeffrey S Kennedy; Robert J Washabau; Paula S Henthorn; Peter F Moore; Simon R Carding; Peter J Felsburg
Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells.
Veterinary immunology and immunopathology 2006;114(3-4):313-9.
2006: Steven E Suter; Terry A Gouthro; Peter A McSweeney; Richard A Nash; Mark E Haskins; Peter J Felsburg; Paula S Henthorn
Optimized transduction of canine paediatric CD34(+) cells using an MSCV-based bicistronic vector.
Veterinary research communications 2006;30(8):881-901.
2006: Anne M Traas; Margret Casal; Mark E Haskins; Paula S Henthorn
Genetic counseling in the era of molecular diagnostics.
Theriogenology 2006;66(3):599-605.
2006: Michael H Goldschmidt; Jeffrey S Kennedy; Douglas R Kennedy; Hang Yuan; David E Holt; Margret L Casal; Anne M Traas; Elizabeth A Mauldin; Peter F Moore; Paula S Henthorn; Brian J Hartnett; Kenneth I Weinberg; Richard Schlegel; Peter J Felsburg
Severe papillomavirus infection progressing to metastatic squamous cell carcinoma in bone marrow-transplanted X-linked SCID dogs.
Journal of virology 2006;80(13):6621-8.
2006: Margret L Casal; Richard M Munuve; M Anne Janis; Petra Werner; Paula S Henthorn
Epilepsy in Irish Wolfhounds.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2006;20(1):131-5.
2005: Margret L Casal; Jennifer L Scheidt; James L Rhodes; Paula S Henthorn; Petra Werner
Mutation identification in a canine model of X-linked ectodermal dysplasia.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(7):524-31.
2005: Petra Werner; Michael G Raducha; Ulana Prociuk; Elaine A Ostrander; Richard S Spielman; Ewen F Kirkness; Donald F Patterson; Paula S Henthorn
The keeshond defect in cardiac conotruncal development is oligogenic.
Human genetics 2005;116(5):368-77.
2004: Steven E Suter; Terry A Gouthro; Peter A McSweeney; Richard A Nash; Mark E Haskins; Peter J Felsburg; Paula S Henthorn
Isolation and characterization of pediatric canine bone marrow CD34+ cells.
Veterinary immunology and immunopathology 2004;101(1-2):31-47.
2004: Margret L Casal; Donna M Dambach; T Meister; Peter Jezyk; Donald F Patterson; Paula S Henthorn
Familial glomerulonephropathy in the Bullmastiff.
Veterinary pathology 2004;41(4):319-25.
2004: Petra Werner; Michael G Raducha; D Shin; Elaine A Ostrander; Ewen F Kirkness; Donald F Patterson; Paula S Henthorn
Assignment of 10 canine genes to the canine linkage and comparative maps.
Animal genetics 2004;35(3):249-51.
2003: Qianchuan He; John C Fyfe; Alejandro A Schäffer; Adam Kilkenney; Petra Werner; Ewen F Kirkness; Paula S Henthorn
Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(11):758-64.
2003: Peter J Felsburg; Brian J Hartnett; Terry A Gouthro; Paula S Henthorn
Thymopoiesis and T cell development in common gamma chain-deficient dogs.
Immunologic research 2003;27(2-3):235-46.
2002: Susan E Kimmel; Cynthia R Ward; Paula S Henthorn; Rebecka S Hess
Familial insulin-dependent diabetes mellitus in Samoyed dogs.
Journal of the American Animal Hospital Association 2002;38(3):235-8.
2002: Thomas Licht; Mark E Haskins; Paula S Henthorn; Sandra E Kleiman; David M Bodine; Todd Whitwam; Jennifer M Puck; Michael M Gottesman; John R Melniczek
Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3123-8.
2002: Steven Mumm; Jonathan Jones; Patrick M Finnegan; Paula S Henthorn; Michelle N Podgornik; Michael P Whyte
Denaturing gradient gel electrophoresis analysis of the tissue nonspecific alkaline phosphatase isoenzyme gene in hypophosphatasia.
Molecular genetics and metabolism 2002;75(2):143-53.
2002: Brian J Hartnett; DaPeng Yao; Steven E Suter; N Matthew Ellinwood; Paula S Henthorn; Peter F Moore; Peter A McSweeney; Richard A Nash; Jeffrey D Brown; Kenneth I Weinberg; Peter J Felsburg
Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(4):188-97.
2002: Meg M Sleeper; Paula S Henthorn; Camasamudram Vijayasarathy; Donna M Dambach; Tim Bowers; Pierre Tijskens; Clara F Armstrong; Edward B Lankford
Dilated cardiomyopathy in juvenile Portuguese Water Dogs.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2002;16(1):52-62.
2001: Meg M Sleeper; Paula S Henthorn; Edward B Lankford
Differing opinion regarding the etiology of juvenile cardiomyopathy in Portuguese water dogs.
American journal of medical genetics 2001;104(3):262-4.
2000: Paula S Henthorn; J Liu; T Gidalevich; J Fang; Margret L Casal; Donald F Patterson; Urs Giger
Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs.
Human genetics 2000;107(4):295-303.
1999: John R Melniczek; Donna M Dambach; Ulana Prociuk; Peter Jezyk; Paula S Henthorn; Donald F Patterson; Urs Giger
Sry-negative XX sex reversal in a family of Norwegian Elkhounds.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1999;13(6):564-9.
1999: Brian J Hartnett; Paula S Henthorn; Peter F Moore; Kenneth I Weinberg; HD Ochs; Peter J Felsburg
Bone marrow transplantation for canine X-linked severe combined immunodeficiency.
Veterinary immunology and immunopathology 1999;69(2-4):137-44.
1999: Peter J Felsburg; Brian J Hartnett; Paula S Henthorn; Peter F Moore; S Krakowka; HD Ochs
Canine X-linked severe combined immunodeficiency.
Veterinary immunology and immunopathology 1999;69(2-4):127-35.
1999: Petra Werner; Cathryn S Mellersh; Michael G Raducha; SA DeRose; Gregory M Acland; Ulana Prociuk; NA Wiegand; Gustavo D Aguirre; Paula S Henthorn; Donald F Patterson; Elaine A Ostrander
Anchoring of canine linkage groups with chromosome-specific markers.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(8):814-23.
1999: Petra Werner; Michael G Raducha; Ulana Prociuk; Marcia L Budarf; Paula S Henthorn; Donald F Patterson
Comparative mapping of the DiGeorge region in the dog and exclusion of linkage to inherited canine conotruncal heart defects.
The Journal of heredity 1999;90(4):494-8.
1999: John C Fyfe; Rebeccah Kurzhals; M E Lassaline; Paula S Henthorn; P R Alur; P Wang; John H Wolfe; Urs Giger; Mark E Haskins; Donald F Patterson; H Sun; S Jain; Naoya Yuhki
Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII.
Genomics 1999;58(2):121-8.
1999: Todd Whitwam; Mark E Haskins; Paula S Henthorn; David M Bodine; Jennifer M Puck
Canine lymphocyte expression of retrovirally transferred human common gamma chain.
Annals of the New York Academy of Sciences 1999;872():387-90.
1999: Barbara Kohn; Paula S Henthorn; Yashoda Rajpurohit; M P Reilly; Toshio Asakura; Urs Giger
Feline adult beta-globin polymorphism reflected in restriction fragment length patterns.
The Journal of heredity 1999;90(1):177-81.
1999: Petra Werner; Michael G Raducha; Ulana Prociuk; Paula S Henthorn; Donald F Patterson
A comparative approach to physical and linkage mapping of genes on canine chromosomes using gene-associated simple sequence repeat polymorphisms illustrated by studies of dog chromosome 9.
The Journal of heredity 1999;90(1):39-42.
1998: Todd Whitwam; Mark E Haskins; Paula S Henthorn; J N Kraszewski; Sandra E Kleiman; Nancy E Seidel; David M Bodine; Jennifer M Puck
Retroviral marking of canine bone marrow: long-term, high-level expression of human interleukin-2 receptor common gamma chain in canine lymphocytes.
Blood 1998;92(5):1565-75.
1998: Petra Werner; Michael G Raducha; Ulana Prociuk; L A Lyons; James Kehler; Paula S Henthorn; Donald F Patterson
RXRA and HSPA5 map to the telomeric end of dog chromosome 9.
Animal genetics 1998;29(3):220-3.
1998: J Ray; A Bouvet; C DeSanto; John C Fyfe; D Xu; John H Wolfe; Gustavo D Aguirre; Donald F Patterson; Mark E Haskins; Paula S Henthorn
Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells.
Genomics 1998;48(2):248-53.
1998: Peter J Felsburg; RL Somberg; Brian J Hartnett; Paula S Henthorn; Simon R Carding
Canine X-linked severe combined immunodeficiency. A model for investigating the requirement for the common gamma chain (gamma c) in human lymphocyte development and function.
Immunologic research 1998;17(1-2):63-73.
1997: R P Pullen; RL Somberg; Peter J Felsburg; Paula S Henthorn
X-linked severe combined immunodeficiency in a family of Cardigan Welsh corgis.
Journal of the American Animal Hospital Association 1997;33(6):494-9.
1997: Peter J Felsburg; RL Somberg; Brian J Hartnett; S F Suter; Paula S Henthorn; Peter F Moore; Kenneth I Weinberg; HD Ochs
Full immunologic reconstitution following nonconditioned bone marrow transplantation for canine X-linked severe combined immunodeficiency.
Blood 1997;90(8):3214-21.
1997: Petra Werner; Michael G Raducha; Ulana Prociuk; Paula S Henthorn; Donald F Patterson
Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5.
Genomics 1997;42(1):74-82.
1997: Jennifer M Puck; AE Pepper; Paula S Henthorn; Fabio Candotti; J Isakov; Todd Whitwam; Mary Ellen Conley; Roxanne E Fischer; Howard M Rosenblatt; Trudy N Small; Rebecca H Buckley
Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency.
Blood 1997;89(6):1968-77.
1996: B F Smith; H Stedman; Y Rajpurohit; Paula S Henthorn; John H Wolfe; Donald F Patterson; Urs Giger
Molecular basis of canine muscle type phosphofructokinase deficiency.
The Journal of biological chemistry 1996;271(33):20070-4.
1996: Kenton Fedde; M P Michell; Paula S Henthorn; Michael P Whyte
Aberrant properties of alkaline phosphatase in patient fibroblasts correlate with clinical expressivity in severe forms of hypophosphatasia.
The Journal of clinical endocrinology and metabolism 1996;81(7):2587-94.
1996: Michael P Whyte; D A Walkenhorst; Kenton Fedde; Paula S Henthorn; C S Hill
Hypophosphatasia: levels of bone alkaline phosphatase immunoreactivity in serum reflect disease severity.
The Journal of clinical endocrinology and metabolism 1996;81(6):2142-8.
1996: A Tipold; RL Somberg; Paula S Henthorn; Michael G Raducha; P Feesburg
Restriction fragment length polymorphism of the T-cell receptor beta-chain gene in dogs.
Veterinary immunology and immunopathology 1996;51(3-4):225-33.
1996: RL Somberg; A Tipold; Brian J Hartnett; Peter F Moore; Paula S Henthorn; Peter J Felsburg
Postnatal development of T cells in dogs with X-linked severe combined immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1431-5.
1996: B F Smith; Paula S Henthorn; Y Rajpurohit; H Stedman; John H Wolfe; Donald F Patterson; Urs Giger
A cDNA encoding canine muscle-type phosphofructokinase.
Gene 1996;168(2):275-6.
1995: Paula S Henthorn; Michael P Whyte
Infantile hypophosphatasia: successful prenatal assessment by testing for tissue-non-specific alkaline phosphatase isoenzyme gene mutations.
Prenatal diagnosis 1995;15(11):1001-6.
1995: RL Somberg; R P Pullen; Margret L Casal; Donald F Patterson; Peter J Felsburg; Paula S Henthorn
A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease.
Veterinary immunology and immunopathology 1995;47(3-4):203-13.
1995: Michael P Whyte; M Landt; L M Ryan; R A Mulivor; Paula S Henthorn; Kenton Fedde; J Dennis Mahuren; Stephen P Coburn
Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.
The Journal of clinical investigation 1995;95(4):1440-5.
1994: Paula S Henthorn; RL Somberg; V M Fimiani; Jennifer M Puck; Donald F Patterson; Peter J Felsburg
IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease.
Genomics 1994;23(1):69-74.
1994: S M Deschênes; Jennifer M Puck; Amalia Dutra; RL Somberg; Peter J Felsburg; Paula S Henthorn
Comparative mapping of canine and human proximal Xq and genetic analysis of canine X-linked severe combined immunodeficiency.
Genomics 1994;23(1):62-8.
1993: Jennifer M Puck; S M Deschênes; J C Porter; Amalia Dutra; C J Brown; H F Willard; Paula S Henthorn
The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1.
Human molecular genetics 1993;2(8):1099-104.
1992: Paula S Henthorn; Michael P Whyte
Missense mutations of the tissue-nonspecific alkaline phosphatase gene in hypophosphatasia.
Clinical chemistry 1992;38(12):2501-5.
1992: Paula S Henthorn; Michael G Raducha; Kenton Fedde; M A Lafferty; Michael P Whyte
Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9924-8.
1991: Paula S Henthorn; C C Stewart; Tom Kadesch; Jennifer M Puck
The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22.
Genomics 1991;11(2):374-8.
1991: J M Puck; C C Stewart; Paula S Henthorn
A high-frequency RFLP at the human TFE3 locus on the X chromosome.
Nucleic acids research 1991;19(3):684.
1990: Paula S Henthorn; R McCarrick-Walmsley; Tom Kadesch
Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor.
Nucleic acids research 1990;18(3):678.
1990: Paula S Henthorn; R McCarrick-Walmsley; Tom Kadesch
Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor.
Nucleic acids research 1990;18(3):677.
1990: Paula S Henthorn; Oliver Smithies; D L Mager
Molecular analysis of deletions in the human beta-globin gene cluster: deletion junctions and locations of breakpoints.
Genomics 1990;6(2):226-37.
1990: Paula S Henthorn; M Kiledjian; Tom Kadesch
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
Science (New York, N.Y.) 1990;247(4941):467-70.
1988: Paula S Henthorn; P Zervos; Michael G Raducha; H Harris; Tom Kadesch
Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6342-6.
1988: M J Weiss; K Ray; Paula S Henthorn; B Lamb; Tom Kadesch; H Harris
Structure of the human liver/bone/kidney alkaline phosphatase gene.
The Journal of biological chemistry 1988;263(24):12002-10.
1988: Paula S Henthorn; Michael G Raducha; Tom Kadesch; M J Weiss; H Harris
Sequence and characterization of the human intestinal alkaline phosphatase gene.
The Journal of biological chemistry 1988;263(24):12011-9.
1988: M Smith; M J Weiss; Constance A Griffin; Jeffrey C Murray; K H Buetow; Beverly S Emanuel; Paula S Henthorn; H Harris
Regional assignment of the gene for human liver/bone/kidney alkaline phosphatase to chromosome 1p36.1-p34.
Genomics 1988;2(2):139-43.
1987: Constance A Griffin; M Smith; Paula S Henthorn; H Harris; M J Weiss; Michael G Raducha; Beverly S Emanuel
Human placental and intestinal alkaline phosphatase genes map to 2q34-q37.
American journal of human genetics 1987;41(6):1025-34.
1987: Paula S Henthorn; Michael G Raducha; Y H Edwards; M J Weiss; C Slaughter; M A Lafferty; H Harris
Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(5):1234-8.
1986: M J Weiss; Paula S Henthorn; M A Lafferty; C Slaughter; Michael G Raducha; H Harris
Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7182-6.
1986: Paula S Henthorn; B J Knoll; Michael G Raducha; K N Rothblum; C Slaughter; M Weiss; M A Lafferty; T Fischer; H Harris
Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5597-601.
1986: Paula S Henthorn; D L Mager; T H Huisman; Oliver Smithies
A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(14):5194-8.
1985: D L Mager; Paula S Henthorn; Oliver Smithies
A Chinese G gamma + (A gamma delta beta)zero thalassemia deletion: comparison to other deletions in the human beta-globin gene cluster and sequence analysis of the breakpoints.
Nucleic acids research 1985;13(18):6559-75.
1985: D L Mager; Paula S Henthorn
A retrovirus-like element occurs between the 3' breakpoints of two large deletions in the human beta-globin gene cluster.
Progress in clinical and biological research 1985;191():81-91.
1984: D L Mager; Paula S Henthorn
Identification of a retrovirus-like repetitive element in human DNA.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7510-4.