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Matthias Hentze

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Alfredo Castello; Bernd Fischer; Matthias W Hentze; Thomas Preiss
RNA-binding proteins in Mendelian disease.
Matthias W Hentze; Thomas Preiss
Circular RNAs: splicing's enigma variations.
Bruno Galy; Norbert Gretz; Hermann-Josef Gröne; Christiane Becker; Dunja Ferring-Appel; Klaus Schümann; Matthias W Hentze
Iron regulatory proteins control a mucosal block to intestinal iron absorption.

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All Publications

2013: Alfredo Castello; Bernd Fischer; Matthias W Hentze; Thomas Preiss
RNA-binding proteins in Mendelian disease.
Trends in genetics : TIG 2013;29(5):318-27.
2013: Matthias W Hentze; Thomas Preiss
Circular RNAs: splicing's enigma variations.
The EMBO journal 2013;32(7):923-5.
2013: Bruno Galy; Norbert Gretz; Hermann-Josef Gröne; Christiane Becker; Dunja Ferring-Appel; Klaus Schümann; Matthias W Hentze
Iron regulatory proteins control a mucosal block to intestinal iron absorption.
Cell reports 2013;3(3):844-57.
2013: Alfredo Castello; Katrin Eichelbaum; Bernd Fischer; Rastislav Horos; Jeroen Krijgsveld; Lars M Steinmetz; Claudia Strein; Matthias W Hentze
System-wide identification of RNA-binding proteins by interactome capture.
Nature protocols 2013;8(3):491-500.
2013: Sheila A Anderson; Aimee T Broman; Yuan-I Chang; Alisa Damnernsawad; Kathryn M Deck; Mark D Fleming; Bruno Galy; Matthias W Hentze; Christina Kendziorski; Christopher P Nizzi; Paul J Schmidt; Jing Zhang; Richard S Eisenstein
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
Cell metabolism 2013;17(2):282-90.
2012: Flavia D'Alessio; Matthias W Hentze; Martina U Muckenthaler
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
Journal of hepatology 2012;57(5):1052-60.
2012: Fátima Gebauer; Thomas Preiss; Matthias W Hentze
From cis-regulatory elements to complex RNPs and back.
Cold Spring Harbor perspectives in biology 2012;4(7):a012245.
2012: Alfredo Castello; Norman E Davey; Katrin Eichelbaum; Bernd Fischer; Rastislav Horos; David T Humphreys; Jeroen Krijgsveld; Thomas Preiss; Lars M Steinmetz; Claudia Strein; Benedikt M Beckmann; Matthias W Hentze
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell 2012;149(6):1393-406.
2012: Francesca Moretti; Agnieszka Zdanowicz-Specht; Constanze Kaiser; Matthias W Hentze
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.
Nature structural & molecular biology 2012;19(6):603-8.
2012: Claudia M Casanova; Kent E Duncan; Matthias W Hentze; Beate Neumann; Kerstin Putzker; Peter Sehr; Christian Thoma
Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation.
PloS one 2012;7(9):e45943.
2011: Mayka Sanchez; Bjoern Schwanhaeusser; Matthias Selbach; Martina U Muckenthaler; Tomi Bähr-Ivacevic; Vladimir Benes; Jonathon Blake; Bruno Galy; Matthias W Hentze
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.
Blood 2011;118(22):e168-79.
2011: Jan Medenbach; Markus Seiler; Matthias W Hentze
Translational control via protein-regulated upstream open reading frames.
Cell 2011;145(6):902-13.
2011: Aurélie M Rakotondrafara; Matthias W Hentze
An efficient factor-depleted mammalian in vitro translation system.
Nature protocols 2011;6(5):563-71.
2011: Gabriele Neu-Yilik; Beate Amthor; Niels H Gehring; Sharif Bahri; Helena Paidassi; Matthias W Hentze; Andreas E Kulozik
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.
RNA (New York, N.Y.) 2011;17(5):843-54.
2011: Sven Danckwardt; Anne-Susan Gantzert; Stephan Macher-Goeppinger; Hans Christian Probst; Marc Gentzel; Matthias Wilm; Hermann-Josef Gröne; Peter Schirmacher; Matthias W Hentze; Andreas E Kulozik
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
Molecular cell 2011;41(3):298-310.
2010: Francesca Moretti; Rolf Thermann; Matthias W Hentze
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame.
RNA (New York, N.Y.) 2010;16(12):2493-502.
2010: Madhuri Bhuvanagiri; Anna M Schlitter; Matthias W Hentze; Andreas E Kulozik
NMD: RNA biology meets human genetic medicine.
The Biochemical journal 2010;430(3):365-77.
2010: Lyora A Cohen; Lucia Gutierrez; Avital Weiss; Yael Leichtmann-Bardoogo; De-liang Zhang; Daniel R Crooks; Rachid Sougrat; Avigail Morgenstern; Bruno Galy; Matthias W Hentze; Francisco J Lazaro; Tracey A Rouault; Esther G Meyron-Holtz
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.
Blood 2010;116(9):1574-84.
2010: Bruno Galy; Dunja Ferring-Appel; Sven W Sauer; Sylvia Kaden; Saïd Lyoumi; Herve Puy; Stefan Kölker; Hermann-Josef Gröne; Matthias W Hentze
Iron regulatory proteins secure mitochondrial iron sufficiency and function.
Cell metabolism 2010;12(2):194-201.
2010: Matthias W Hentze; Thomas Preiss
The REM phase of gene regulation.
Trends in biochemical sciences 2010;35(8):423-6.
2010: Matthias W Hentze; Martina U Muckenthaler; Bruno Galy; Clara Camaschella
Two to tango: regulation of Mammalian iron metabolism.
Cell 2010;142(1):24-38.
2010: Mónica Campillos; Ildefonso Cases; Matthias W Hentze; Mayka Sanchez
SIREs: searching for iron-responsive elements.
Nucleic acids research 2010;38(Web Server issue):W360-7.
2010: Katarzyna Mleczko-Sanecka; Guillem Casanovas; Anan Ragab; Katja Breitkopf; Alexandra Müller; Michael Boutros; Steven Dooley; Matthias W Hentze; Martina U Muckenthaler
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.
Blood 2010;115(13):2657-65.
2010: Andrey V Pisarev; Maxim A Skabkin; Vera P Pisareva; Olga V Skabkina; Aurélie M Rakotondrafara; Matthias W Hentze; Christopher U T Hellen; Tatyana V Pestova
The role of ABCE1 in eukaryotic posttermination ribosomal recycling.
Molecular cell 2010;37(2):196-210.
2010: Tiago J S Lopes; Tatyana Luganskaja; Maja Vujić Spasić; Matthias W Hentze; Martina U Muckenthaler; Klaus Schümann; Jens G Reich
Systems analysis of iron metabolism: the network of iron pools and fluxes.
BMC systems biology 2010;4():112.
2010: Yevhen Vainshtein; Mayka Sanchez; Alvis Brazma; Matthias W Hentze; Thomas Dandekar; Martina U Muckenthaler
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays.
BMC bioinformatics 2010;11():112.
2009: Kent E Duncan; Claudia Strein; Matthias W Hentze
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA.
Molecular cell 2009;36(4):571-82.
2009: Agnieszka Zdanowicz; Rolf Thermann; Joanna Kowalska; Jacek Jemielity; Kent Duncan; Thomas Preiss; Edward Darzynkiewicz; Matthias W Hentze
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.
Molecular cell 2009;35(6):881-8.
2009: Lydie Viatte; Hermann-Josef Gröne; Matthias W Hentze; Bruno Galy
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.
Journal of molecular medicine (Berlin, Germany) 2009;87(9):913-21.
2009: Marcello Clerici; André Mourão; Irina Gutsche; Niels H Gehring; Matthias W Hentze; Andreas Kulozik; Jan kadlec; Michael Sattler; Stephen Cusack
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
The EMBO journal 2009;28(15):2293-306.
2009: Niels H Gehring; Styliani Lamprinaki; Matthias W Hentze; Andreas E Kulozik
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
PLoS biology 2009;7(5):e1000120.
2009: Niels H Gehring; Styliani Lamprinaki; Andreas E Kulozik; Matthias W Hentze
Disassembly of exon junction complexes by PYM.
Cell 2009;137(3):536-48.
2009: Guillem Casanovas; Katarzyna Mleczko-Sanecka; Sandro Altamura; Matthias W Hentze; Martina U Muckenthaler
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):471-80.
2009: Matthias W Hentze
EMBO Molecular Medicine: Conquering new frontiers.
EMBO molecular medicine 2009;1(1):5.
2009: Dunja Ferring-Appel; Matthias W Hentze; Bruno Galy
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism.
Blood 2009;113(3):679-87.
2009: Traude H Beilharz; David T Humphreys; Jennifer L Clancy; Rolf Thermann; David I K Martin; Matthias W Hentze; Thomas Preiss
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.
PloS one 2009;4(8):e6783.
2008: Christian Thoma; Sven Fraterman; Marc Gentzel; Matthias Wilm; Matthias W Hentze
Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.
RNA (New York, N.Y.) 2008;14(8):1579-89.
2008: Maria Vittoria Verga Falzacappa; Guillem Casanovas; Matthias W Hentze; Martina U Muckenthaler
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.
Journal of molecular medicine (Berlin, Germany) 2008;86(5):531-40.
2008: Pavel Ivanov; Niels H Gehring; Joachim B Kunz; Matthias W Hentze; Andreas E Kulozik
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
The EMBO journal 2008;27(5):736-47.
2008: Sven Danckwardt; Matthias W Hentze; Andreas E Kulozik
3' end mRNA processing: molecular mechanisms and implications for health and disease.
The EMBO journal 2008;27(3):482-98.
2008: Maja Vujić Spasić; Judit Kiss; Thomas Herrmann; Bruno Galy; Stefanie Martinache; Jens Stolte; Hermann-Josef Gröne; Wolfgang Stremmel; Matthias W Hentze; Martina U Muckenthaler
Hfe acts in hepatocytes to prevent hemochromatosis.
Cell metabolism 2008;7(2):173-8.
2008: Niels H Gehring; Matthias W Hentze; Andreas E Kulozik
Tethering assays to investigate nonsense-mediated mRNA decay activating proteins.
Methods in enzymology 2008;448():467-82.
2008: Martina U Muckenthaler; Bruno Galy; Matthias W Hentze
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.
Annual review of nutrition 2008;28():197-213.
2008: Mirco Castoldi; Sabine Schmidt; Vladimir Benes; Matthias W Hentze; Martina U Muckenthaler
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes.
Nature protocols 2008;3(2):321-9.
2008: Bruno Galy; Dunja Ferring-Appel; Sylvia Kaden; Hermann-Josef Gröne; Matthias W Hentze
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.
Cell metabolism 2008;7(1):79-85.
2007: Susanne Till; erwan lejeune; Rolf Thermann; Miriam Bortfeld; Michael Hothorn; Daniel Enderle; Constanze Heinrich; Matthias W Hentze; Andreas G Ladurner
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
Nature structural & molecular biology 2007;14(10):897-903.
2007: Mirco Castoldi; Vladimir Benes; Matthias W Hentze; Martina U Muckenthaler
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes.
Methods (San Diego, Calif.) 2007;43(2):146-52.
2007: Melanie J Percy; Mayka Sanchez; Sabina Swierczek; Mary Frances McMullin; Mariluz P Mojica-Henshaw; Martina U Muckenthaler; Josef T Prchal; Matthias W Hentze
Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
Blood 2007;110(7):2776-7.
2007: Carine Fillebeen; Martina U Muckenthaler; Bill Andriopoulos; Martin Bisaillon; Zineb Mounir; Matthias W Hentze; Antonis E Koromilas; Kostas Pantopoulos
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.
Journal of hepatology 2007;47(1):12-22.
2007: Rolf Thermann; Matthias W Hentze
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.
Nature 2007;447(7146):875-8.
2007: Sven Danckwardt; Isabelle Kaufmann; Marc Gentzel; Konrad Foerstner; Anne-Susan Gantzert; Niels H Gehring; Gabriele Neu-Yilik; Peer Bork; Walter Keller; Matthias Wilm; Matthias W Hentze; Andreas E Kulozik
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.
The EMBO journal 2007;26(11):2658-69.
2007: Maja Vujic Spasic; Judit Kiss; Thomas Herrmann; Regina Kessler; Jens Stolte; Bruno Galy; Birgit Rathkolb; Eckhard Wolf; Wolfgang Stremmel; Matthias W Hentze; Martina U Muckenthaler
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.
Blood 2007;109(10):4511-7.
2007: Mayka Sanchez; Bruno Galy; Martina U Muckenthaler; Matthias W Hentze
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.
Nature structural & molecular biology 2007;14(5):420-6.
2007: Susanne Ludwiczek; Igor Theurl; Martina U Muckenthaler; Martin Jakab; Sabine M Mair; Milan Theurl; Judit Kiss; Markus Paulmichl; Matthias W Hentze; Markus Ritter; Günter Weiss
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1.
Nature medicine 2007;13(4):448-54.
2007: Fátima Gebauer; Matthias W Hentze
Studying translational control in Drosophila cell-free systems.
Methods in enzymology 2007;429():23-33.
2007: Mayka Sanchez; Bruno Galy; Matthias W Hentze; Martina U Muckenthaler
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays.
Nature protocols 2007;2(8):2033-42.
2007: Marcelo H Viegas; Niels H Gehring; Stephen Breit; Matthias W Hentze; Andreas E Kulozik
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway.
Nucleic acids research 2007;35(13):4542-51.
2007: Marija Mihailovich; Rolf Thermann; Fabio Grohovaz; Matthias W Hentze; Daniele Zacchetti
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.
Nucleic acids research 2007;35(9):2975-85.
2007: Maria Vittoria Verga Falzacappa; Maja Vujic Spasic; Regina Kessler; Jens Stolte; Matthias W Hentze; Martina U Muckenthaler
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.
Blood 2007;109(1):353-8.
2006: Stephanie Boelz; Gabriele Neu-Yilik; Niels H Gehring; Matthias W Hentze; Andreas E Kulozik
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.
Biochemical and biophysical research communications 2006;349(1):186-91.
2006: Bruno Galy; Sabine M Hölter; Thomas Klopstock; Dunja Ferring; Lore Becker; Sylvia Kaden; Wolfgang Wurst; Hermann-Josef Gröne; Matthias W Hentze
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse.
Nature genetics 2006;38(9):967-9; discussion 969-70.
2006: Mayka Sanchez; Bruno Galy; Thomas Dandekar; Peter Bengert; Yevhen Vainshtein; Jens Stolte; Martina U Muckenthaler; Matthias W Hentze
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.
The Journal of biological chemistry 2006;281(32):22865-74.
2006: Jill A Holbrook; Gabriele Neu-Yilik; Niels H Gehring; Andreas E Kulozik; Matthias W Hentze
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay.
EMBO reports 2006;7(7):722-6.
2006: Gianfranca Corna; Bruno Galy; Matthias W Hentze; Gaetano Cairo
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice.
Journal of molecular medicine (Berlin, Germany) 2006;84(7):551-60.
2006: Joachim B Kunz; Gabriele Neu-Yilik; Matthias W Hentze; Andreas E Kulozik; Niels H Gehring
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
RNA (New York, N.Y.) 2006;12(6):1015-22.
2006: Sven Danckwardt; K Hartmann; B Katz; Matthias W Hentze; Y Levy; R Eichele; varda deutsch; Andreas E Kulozik; O Ben-Tal
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1078-85.
2006: Mirco Castoldi; Sabine Schmidt; Vladimir Benes; Mikkel Noerholm; Andreas E Kulozik; Matthias W Hentze; Martina U Muckenthaler
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA).
RNA (New York, N.Y.) 2006;12(5):913-20.
2006: Hoyin Mok; Agnieszka E Mlodnicka; Matthias W Hentze; Martina U Muckenthaler; Armin Schumacher
The molecular circuitry regulating the switch between iron deficiency and overload in mice.
The Journal of biological chemistry 2006;281(12):7946-51.
2006: Marina Chekulaeva; Matthias W Hentze; Anne Ephrussi
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
Cell 2006;124(3):521-33.
2006: Kent Duncan; Marica Grskovic; Claudia Strein; Karsten Beckmann; Ricarda Niggeweg; Irina Abaza; Fátima Gebauer; Matthias Wilm; Matthias W Hentze
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation.
Genes & development 2006;20(3):368-79.
2006: Clemens Stockklausner; Stephen Breit; Gabriele Neu-Yilik; Nicole Echner; Matthias W Hentze; Andreas E Kulozik; Niels H Gehring
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).
Nucleic acids research 2006;34(8):2355-63.
2006: Sven Danckwardt; Kathrin Hartmann; Niels H Gehring; Matthias W Hentze; Andreas E Kulozik
3' end processing of the prothrombin mRNA in thrombophilia.
Acta haematologica 2006;115(3-4):192-7.
2005: Bruno Galy; Dunja Ferring; Matthias W Hentze
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.
Genesis (New York, N.Y. : 2000) 2005;43(4):181-8.
2005: Niels H Gehring; Joachim B Kunz; Gabriele Neu-Yilik; Stephen Breit; Marcelo H Viegas; Matthias W Hentze; Andreas E Kulozik
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
Molecular cell 2005;20(1):65-75.
2005: Bruno Galy; Dunja Ferring; Belen Minana; Oliver Bell; Heinz G Janser; Martina U Muckenthaler; Klaus Schümann; Matthias W Hentze
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).
Blood 2005;106(7):2580-9.
2005: Patrick Hundsdoerfer; Christian Thoma; Matthias W Hentze
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13421-6.
2005: Karsten Beckmann; Marica Grskovic; Fátima Gebauer; Matthias W Hentze
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila.
Cell 2005;122(4):529-40.
2005: Carine Fillebeen; Ana María Rivas-Estilla; Martin Bisaillon; Prem Ponka; Martina U Muckenthaler; Matthias W Hentze; Antonis E Koromilas; Kostas Pantopoulos
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
The Journal of biological chemistry 2005;280(10):9049-57.
2004: Fátima Gebauer; Matthias W Hentze
Molecular mechanisms of translational control.
Nature reviews. Molecular cell biology 2004;5(10):827-35.
2004: Christian Thoma; Giovanna Bergamini; Bruno Galy; Patrick Hundsdoerfer; Matthias W Hentze
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP.
Molecular cell 2004;15(6):925-35.
2004: Martina U Muckenthaler; Pedro Rodrigues; Maria G Macedo; Belen Minana; Karen Brennan; Elsa M Cardoso; Matthias W Hentze; Maria de Sousa
Molecular analysis of iron overload in beta2-microglobulin-deficient mice.
Blood cells, molecules & diseases 2004;33(2):125-31.
2004: Jill A Holbrook; Gabriele Neu-Yilik; Matthias W Hentze; Andreas E Kulozik
Nonsense-mediated decay approaches the clinic.
Nature genetics 2004;36(8):801-8.
2004: Sven Danckwardt; Niels H Gehring; Gabriele Neu-Yilik; Patrick Hundsdoerfer; Margit Pforsich; Ute Frede; Matthias W Hentze; Andreas E Kulozik
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.
Blood 2004;104(2):428-35.
2004: Bruno Galy; Dunja Ferring; Monika Benesova; Vladimir Benes; Matthias W Hentze
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.
RNA (New York, N.Y.) 2004;10(7):1019-25.
2004: CINDY ROY; Angel O Custodio; Jos de Graaf; Susanne Schneider; Imo Akpan; Lynne K Montross; Mayka Sanchez; Alessandro Gaudino; Matthias W Hentze; Nancy C Andrews; Martina U Muckenthaler
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
Nature genetics 2004;36(5):481-5.
2004: Robert A Bonnah; Martina U Muckenthaler; Hanqian L Carlson; Belen Minana; Caroline A Enns; Matthias W Hentze; Magdalene So
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.
Cellular microbiology 2004;6(5):473-84.
2004: Matthias W Hentze; Martina U Muckenthaler; Nancy C Andrews
Balancing acts: molecular control of mammalian iron metabolism.
Cell 2004;117(3):285-97.
2004: Jian Wang; Guohua Chen; Martina U Muckenthaler; Bruno Galy; Matthias W Hentze; Kostas Pantopoulos
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.
Molecular and cellular biology 2004;24(3):954-65.
2004: Gabriele Neu-Yilik; Niels H Gehring; Matthias W Hentze; Andreas E Kulozik
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.
Genome biology 2004;5(4):218.
2004: Christian Thoma; Antje Ostareck-Lederer; Matthias W Hentze
A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells.
Methods in molecular biology (Clifton, N.J.) 2004;257():171-80.
2004: Julie Baron-Benhamou; Niels H Gehring; Andreas E Kulozik; Matthias W Hentze
Using the lambdaN peptide to tether proteins to RNAs.
Methods in molecular biology (Clifton, N.J.) 2004;257():135-54.
2004: Thomas Herrmann; Martina U Muckenthaler; Frank van der Hoeven; Karen Brennan; Sven G Gehrke; Nadia Hubert; Consolato Sergi; Hermann-Josef Gröne; Iris Kaiser; Isabella Gosch; Martin Volkmann; Hans-Dieter Riedel; Matthias W Hentze; A Francis Stewart; Wolfgang Stremmel
Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.
Journal of molecular medicine (Berlin, Germany) 2004;82(1):39-48.
2003: Thomas Preiss; Julie Baron-Benhamou; Wilhelm Ansorge; Matthias W Hentze
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.
Nature structural biology 2003;10(12):1039-47.
2003: Tetsuo Ohnishi; Akio Yamashita; Isao Kashima; Thomas Schell; Kirk R Anders; Andrew Grimson; Takahisa Hachiya; Matthias W Hentze; Philip Anderson; Shigeo Ohno
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
Molecular cell 2003;12(5):1187-200.
2003: Marica Grskovic; Matthias W Hentze; Fátima Gebauer
A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA.
The EMBO journal 2003;22(20):5571-81.
2003: Thomas Schell; Thomas Köcher; Matthias Wilm; Bertrand Seraphin; Andreas E Kulozik; Matthias W Hentze
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.
The Biochemical journal 2003;373(Pt 3):775-83.
2003: Julie Baron-Benhamou; Puri Fortes; Toshifumi Inada; Thomas Preiss; Matthias W Hentze
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast.
RNA (New York, N.Y.) 2003;9(6):654-62.
2003: Fátima Gebauer; Marica Grskovic; Matthias W Hentze
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA.
Molecular cell 2003;11(5):1397-404.
2003: Martina U Muckenthaler; CINDY ROY; Angel O Custodio; Belén Miñana; Jos deGraaf; Lynne K Montross; Nancy C Andrews; Matthias W Hentze
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
Nature genetics 2003;34(1):102-7.
2003: Martina U Muckenthaler; Alexandra Richter; Nikolas Gunkel; Dieter Riedel; Maria Polycarpou-Schwarz; Sabine Hentze; Mechthild Falkenhahn; Wolfgang Stremmel; Wilhelm Ansorge; Matthias W Hentze
Relationships and distinctions in iron-regulatory networks responding to interrelated signals.
Blood 2003;101(9):3690-8.
2003: Niels H Gehring; Gabriele Neu-Yilik; Thomas Schell; Matthias W Hentze; Andreas E Kulozik
Y14 and hUpf3b form an NMD-activating complex.
Molecular cell 2003;11(4):939-49.
2003: Khristy Thompson; Sharon Menzies; Martina U Muckenthaler; Frank M Torti; Teresa Wood; Suzy V Torti; Matthias W Hentze; John Beard; James Connor
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.
Journal of neuroscience research 2003;71(1):46-63.
2002: Nadia Hubert; Matthias W Hentze
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12345-50.
2002: Klaus Schümann; Berit Borch-Iohnsen; Matthias W Hentze; Joannes Marx
Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board.
The American journal of clinical nutrition 2002;76(3):499-500.
2002: Antje Ostareck-Lederer; Dirk H Ostareck; Christophe Cans; Gitte Neubauer; Karol Bomsztyk; Giulio Superti-Furga; Matthias W Hentze
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Molecular and cellular biology 2002;22(13):4535-43.
2002: Sven Danckwardt; Gabriele Neu-Yilik; Rolf Thermann; Ute Frede; Matthias W Hentze; Andreas E Kulozik
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay.
Blood 2002;99(5):1811-6.
2002: Katja S Brocke; Gabriele Neu-Yilik; Niels H Gehring; Matthias W Hentze; Andreas E Kulozik
The human intronless melanocortin 4-receptor gene is NMD insensitive.
Human molecular genetics 2002;11(3):331-5.
2002: Thomas Schell; Andreas E Kulozik; Matthias W Hentze
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.
Genome biology 2002;3(3):REVIEWS1006.
2001: Hiromi Gunshin; Charles R Allerson; Maria Polycarpou-Schwarz; A Rofts; Jack T Rogers; F Kishi; Matthias W Hentze; Tracey A Rouault; Nancy C Andrews; Matthias A Hediger
Iron-dependent regulation of the divalent metal ion transporter.
FEBS letters 2001;509(2):309-16.
2001: Matthias W Hentze
Protein synthesis. Believe it or not-translation in the nucleus.
Science (New York, N.Y.) 2001;293(5532):1058-9.
2001: Fátima Gebauer; Matthias W Hentze
Fertility facts: male and female germ cell development requires translational control by CPEB.
Molecular cell 2001;8(2):247-9.
2001: Niels H Gehring; Ute Frede; Gabriele Neu-Yilik; Patrick Hundsdoerfer; Barbara Vetter; Matthias W Hentze; Andreas E Kulozik
Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia.
Nature genetics 2001;28(4):389-92.
2001: Sebastian Mueller; Kostas Pantopoulos; C A Hübner; Wolfgang Stremmel; Matthias W Hentze
IRP1 activation by extracellular oxidative stress in the perfused rat liver.
The Journal of biological chemistry 2001;276(25):23192-6.
2001: Gabriele Neu-Yilik; Niels H Gehring; Rolf Thermann; Ute Frede; Matthias W Hentze; Andreas E Kulozik
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.
The EMBO journal 2001;20(3):532-40.
2001: Dirk H Ostareck; Antje Ostareck-Lederer; I N Shatsky; Matthias W Hentze
Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining.
Cell 2001;104(2):281-90.
2001: Fátima Gebauer; Dirk H Ostareck; Antje Ostareck-Lederer; Marica Grskovic; Matthias W Hentze
Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?
Cold Spring Harbor symposia on quantitative biology 2001;66():329-36.
2001: E De Gregorio; J Baron; Thomas Preiss; Matthias W Hentze
Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.
RNA (New York, N.Y.) 2001;7(1):106-13.
2000: G Bergamini; Thomas Preiss; Matthias W Hentze
Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system.
RNA (New York, N.Y.) 2000;6(12):1781-90.
2000: Matthias W Hentze; Elisa Izaurralde; Bertrand Séraphin
A new era for the RNA world. Conference: RNA 2000.
EMBO reports 2000;1(5):394-8.
2000: Puri Fortes; T Inada; Thomas Preiss; Matthias W Hentze; Iain W Mattaj; A B Sachs
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation.
Molecular cell 2000;6(1):191-6.
2000: Martin Volkmann; JH Schiff; M Hör; Matthias W Hentze; Walter Fiehn; J Merkt
[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract].
Der Internist 2000;41(4):381-4.
2000: Stefania Castagnetti; Matthias W Hentze; Anne Ephrussi; Fátima Gebauer
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.
Development (Cambridge, England) 2000;127(5):1063-8.
1999: Hans-Dieter Riedel; Martina U Muckenthaler; Sven G Gehrke; I Mohr; K Brennan; Thomas Herrmann; BA Fitscher; Matthias W Hentze; Wolfgang Stremmel
HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.
Blood 1999;94(11):3915-21.
1999: Fátima Gebauer; davide corona; Thomas Preiss; Peter B Becker; Matthias W Hentze
Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail.
The EMBO journal 1999;18(21):6146-54.
1999: Thomas Preiss; Matthias W Hentze
From factors to mechanisms: translation and translational control in eukaryotes.
Current opinion in genetics & development 1999;9(5):515-21.
1999: E De Gregorio; Thomas Preiss; Matthias W Hentze
Translation driven by an eIF4G core domain in vivo.
The EMBO journal 1999;18(17):4865-74.
1999: V Gegout; J Schlegl; B Schläger; Matthias W Hentze; J Reinbolt; Bernard Ehresmann; Chantal Ehresmann; Pascale Romby
Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting.
The Journal of biological chemistry 1999;274(21):15052-8.
1999: N H Gehring; Matthias W Hentze; Kostas Pantopoulos
Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress.
The Journal of biological chemistry 1999;274(10):6219-25.
1999: Matthias W Hentze; A E Kulozik
A perfect message: RNA surveillance and nonsense-mediated decay.
Cell 1999;96(3):307-10.
1999: E Paraskeva; N K Gray; B Schläger; K Wehr; Matthias W Hentze
Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements.
Molecular and cellular biology 1999;19(1):807-16.
1998: Antje Ostareck-Lederer; Dirk H Ostareck; Matthias W Hentze
Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
Trends in biochemical sciences 1998;23(11):409-11.
1998: Thomas Preiss; Martina U Muckenthaler; Matthias W Hentze
Poly(A)-tail-promoted translation in yeast: implications for translational control.
RNA (New York, N.Y.) 1998;4(11):1321-31.
1998: Martina U Muckenthaler; N K Gray; Matthias W Hentze
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.
Molecular cell 1998;2(3):383-8.
1998: Kostas Pantopoulos; Matthias W Hentze
Activation of iron regulatory protein-1 by oxidative stress in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10559-63.
1998: E De Gregorio; Thomas Preiss; Matthias W Hentze
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent.
RNA (New York, N.Y.) 1998;4(7):828-36.
1998: Rolf Thermann; Gabriele Neu-Yilik; A Deters; Ute Frede; K Wehr; Christian Hagemeier; Matthias W Hentze; Andreas E Kulozik
Binary specification of nonsense codons by splicing and cytoplasmic translation.
The EMBO journal 1998;17(12):3484-94.
1998: Martina U Muckenthaler; Nikolas Gunkel; D Frishman; A Cyrklaff; P Tomancak; Matthias W Hentze
Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans.
European journal of biochemistry / FEBS 1998;254(2):230-7.
1998: Thomas Preiss; Matthias W Hentze
Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast.
Nature 1998;392(6675):516-20.
1998: E Paraskeva; Ann Atzberger; Matthias W Hentze
A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):951-6.
1998: Fátima Gebauer; Livia Merendino; Matthias W Hentze; Juan Valcárcel
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.
RNA (New York, N.Y.) 1998;4(2):142-50.
1998: Thomas Dandekar; K Beyer; Peer Bork; MR Kenealy; Kostas Pantopoulos; Matthias W Hentze; V Sonntag-Buck; Gilles Flouriot; Frank Gannon; S Schreiber
Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches.
Bioinformatics (Oxford, England) 1998;14(3):271-8.
1997: J Schlegl; V Gegout; B Schläger; Matthias W Hentze; Eric Westhof; Chantal Ehresmann; Bernard Ehresmann; Pascale Romby
Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.
RNA (New York, N.Y.) 1997;3(10):1159-72.
1997: Martina U Muckenthaler; Nikolas Gunkel; R Stripecke; Matthias W Hentze
Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association.
RNA (New York, N.Y.) 1997;3(9):983-95.
1997: Dirk H Ostareck; Antje Ostareck-Lederer; Matthias Wilm; Bernd-Joachim Thiele; Matthias Mann; Matthias W Hentze
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.
Cell 1997;89(4):597-606.
1997: Kostas Pantopoulos; Sebastian Mueller; Ann Atzberger; Wilhelm Ansorge; Wolfgang Stremmel; Matthias W Hentze
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
The Journal of biological chemistry 1997;272(15):9802-8.
1997: Matthias W Hentze
eIF4G: a multipurpose ribosome adapter?
Science (New York, N.Y.) 1997;275(5299):500-1.
1997: Martina U Muckenthaler; Matthias W Hentze
Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins.
Progress in molecular and subcellular biology 1997;18():93-115.
1997: G Weiss; C Bogdan; Matthias W Hentze
Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):420-5.
1996: Matthias W Hentze; Lukas C Kühn
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8175-82.
1996: D Frishman; Matthias W Hentze
Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships.
European journal of biochemistry / FEBS 1996;239(1):197-200.
1996: Kostas Pantopoulos; Günter Weiss; Matthias W Hentze
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways.
Molecular and cellular biology 1996;16(7):3781-8.
1996: E Paraskeva; Matthias W Hentze
Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1.
FEBS letters 1996;389(1):40-3.
1996: N K Gray; Kostas Pantopoulos; Thomas Dandekar; B A Ackrell; Matthias W Hentze
Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4925-30.
1995: Kostas Pantopoulos; Matthias W Hentze
Rapid responses to oxidative stress mediated by iron regulatory protein.
The EMBO journal 1995;14(12):2917-24.
1995: Matthias W Hentze
Translational regulation: versatile mechanisms for metabolic and developmental control.
Current opinion in cell biology 1995;7(3):393-8.
1995: Kostas Pantopoulos; N K Gray; Matthias W Hentze
Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.
RNA (New York, N.Y.) 1995;1(2):155-63.
1995: Kostas Pantopoulos; Matthias W Hentze
Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1267-71.
1995: Thomas Dandekar; Matthias W Hentze
Finding the hairpin in the haystack: searching for RNA motifs.
Trends in genetics : TIG 1995;11(2):45-50.
1994: H E Johansson; G J Belsham; BS Sproat; Matthias W Hentze
Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides.
Nucleic acids research 1994;22(22):4591-8.
1994: R Stripecke; C C Oliveira; J E McCarthy; Matthias W Hentze
Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.
Molecular and cellular biology 1994;14(9):5898-909.
1994: Günter Weiss; Gabriele Werner-Felmayer; Ernst R Werner; Kurt Grünewald; H Wachter; Matthias W Hentze
Iron regulates nitric oxide synthase activity by controlling nuclear transcription.
The Journal of experimental medicine 1994;180(3):969-76.
1994: N K Gray; Matthias W Hentze
Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.
The EMBO journal 1994;13(16):3882-91.
1994: N K Gray; Matthias W Hentze
Regulation of protein synthesis by mRNA structure.
Molecular biology reports 1994;19(3):195-200.
1994: Kostas Pantopoulos; Günter Weiss; Matthias W Hentze
Nitric oxide and the post-transcriptional control of cellular iron traffic.
Trends in cell biology 1994;4(3):82-6.
1994: Matthias W Hentze
Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?
Trends in biochemical sciences 1994;19(3):101-3.
1994: Kostas Pantopoulos; H E Johansson; Matthias W Hentze
The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.
Progress in nucleic acid research and molecular biology 1994;48():181-238.
1994: Matthias W Hentze
Translational control by iron-responsive elements.
Advances in experimental medicine and biology 1994;356():119-26.
1994: Günter Weiss; B Goossen; Wolfgang Doppler; Dietmar Fuchs; Kostas Pantopoulos; Gabriele Werner-Felmayer; Kurt Grünewald; H Wachter; Matthias W Hentze
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.
Advances in experimental medicine and biology 1994;356():133-9.
1993: N K Gray; S Quick; B Goossen; A Constable; H Hirling; Lukas C Kühn; Matthias W Hentze
Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch.
European journal of biochemistry / FEBS 1993;218(2):657-67.
1993: ojar melefors; Matthias W Hentze
Iron regulatory factor--the conductor of cellular iron regulation.
Blood reviews 1993;7(4):251-8.
1993: C C Oliveira; B Goossen; N I Zanchin; John E G McCarthy; Matthias W Hentze; R Stripecke
Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae.
Nucleic acids research 1993;21(23):5316-22.
1993: Günter Weiss; B Goossen; Wolfgang Doppler; D Fuchs; Kostas Pantopoulos; Gabriele Werner-Felmayer; H Wachter; Matthias W Hentze
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.
The EMBO journal 1993;12(9):3651-7.
1993: ojar melefors; B Goossen; H E Johansson; R Stripecke; N K Gray; Matthias W Hentze
Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.
The Journal of biological chemistry 1993;268(8):5974-8.
1993: ojar melefors; Matthias W Hentze
Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(2):85-90.
1992: R Stripecke; Matthias W Hentze
Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro.
Nucleic acids research 1992;20(21):5555-64.
1992: A Constable; S Quick; N K Gray; Matthias W Hentze
Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4554-8.
1992: B Goossen; Matthias W Hentze
Position is the critical determinant for function of iron-responsive elements as translational regulators.
Molecular and cellular biology 1992;12(5):1959-66.
1991: Thomas Dandekar; R Stripecke; N K Gray; B Goossen; A Constable; H E Johansson; Matthias W Hentze
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
The EMBO journal 1991;10(7):1903-9.
1991: Matthias W Hentze; P Argos
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
Nucleic acids research 1991;19(8):1739-40.
1991: H E Johansson; N De Groot; A A Hochberg; Matthias W Hentze
Effect of heparin contained in preparations of small cytoplasmic RNAs on cell-free translation.
The Journal of biological chemistry 1991;266(3):1921-5.
1991: Matthias W Hentze
Translational regulation of ferritin biosynthesis by iron: a review.
Current studies in hematology and blood transfusion 1991;(58):115-26.
1990: B Goossen; S W Caughman; J B Harford; Richard D Klausner; Matthias W Hentze
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.
The EMBO journal 1990;9(12):4127-33.
1990: Matthias W Hentze; B Goossen; S W Caughman
Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.
Molecular biology reports 1990;14(2-3):61.
1990: Matthias W Hentze
Overcoming inhibitions. Translational Control sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, September 13-17, 1989.
The New biologist 1990;2(1):33-6.
1989: David Haile; Matthias W Hentze; Tracey A Rouault; J B Harford; Richard D Klausner
Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.
Molecular and cellular biology 1989;9(11):5055-61.
1989: Matthias W Hentze; H N Seuanez; Stephen J O'Brien; J B Harford; Richard D Klausner
Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.
Nucleic acids research 1989;17(15):6103-8.
1989: Tracey A Rouault; Matthias W Hentze; David Haile; J B Harford; Richard D Klausner
The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5768-72.
1989: David M Koeller; J L Casey; Matthias W Hentze; E M Gerhardt; L N Chan; Richard D Klausner; J B Harford
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3574-8.
1989: Matthias W Hentze; Tracey A Rouault; J B Harford; Richard D Klausner
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Science (New York, N.Y.) 1989;244(4902):357-9.
1988: S W Caughman; Matthias W Hentze; Tracey A Rouault; J B Harford; Richard D Klausner
The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.
The Journal of biological chemistry 1988;263(35):19048-52.
1988: Matthias W Hentze; S W Caughman; J L Casey; David M Koeller; Tracey A Rouault; J B Harford; Richard D Klausner
A model for the structure and functions of iron-responsive elements.
Gene 1988;72(1-2):201-8.
1988: Tracey A Rouault; Matthias W Hentze; S W Caughman; J B Harford; Richard D Klausner
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.
Science (New York, N.Y.) 1988;241(4870):1207-10.
1988: J L Casey; Matthias W Hentze; David M Koeller; S W Caughman; Tracey A Rouault; Richard D Klausner; J B Harford
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
Science (New York, N.Y.) 1988;240(4854):924-8.
1987: Matthias W Hentze; S W Caughman; Tracey A Rouault; J G Barriocanal; Andrew Dancis; J B Harford; Richard D Klausner
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
Science (New York, N.Y.) 1987;238(4833):1570-3.
1987: Matthias W Hentze; Tracey A Rouault; S W Caughman; Andrew Dancis; J B Harford; Richard D Klausner
A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6730-4.
1987: Tracey A Rouault; Matthias W Hentze; Andrew Dancis; W Caughman; J B Harford; R D Klausner
Influence of altered transcription on the translational control of human ferritin expression.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6335-9.