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Matthias Hentze

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
33
Muckenthaler, Martina
27
Kulozik, Andreas
18
Gehring, Niels
17
Pantopoulos, Kostas
15
Neu-Yilik, Gabriele
14
Galy, Bruno
12
Klausner, Richard
12
Preiss, Thomas
11
Rouault, Tracey
9
Gebauer, Fátima
7
Stremmel, Wolfgang
7
Thermann, Rolf
6
Weiss, Günter
6
Ostareck-Lederer, Antje
6
Danckwardt, Sven

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Publications

TOP 3
Zdanowicz Agnieszka; Thermann Rolf; Kowalska Joanna; Jemielity Jacek; Duncan Kent; Preiss Thomas; Darzynkiewicz Edward; Hentze Matthias W
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.
Viatte Lydie; Gröne Hermann-Josef; Hentze Matthias W; Galy Bruno
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.
Gehring Niels H; Lamprinaki Styliani; Hentze Matthias W; Kulozik Andreas E
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

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All Publications

2009: Zdanowicz Agnieszka; Thermann Rolf; Kowalska Joanna; Jemielity Jacek; Duncan Kent; Preiss Thomas; Darzynkiewicz Edward; Hentze Matthias W
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.
Molecular cell 2009;35(6):881-8.
2009: Viatte Lydie; Gröne Hermann-Josef; Hentze Matthias W; Galy Bruno
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.
Journal of molecular medicine (Berlin, Germany) 2009;87(9):913-21.
2009: Gehring Niels H; Lamprinaki Styliani; Hentze Matthias W; Kulozik Andreas E
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
PLoS biology 2009;7(5):e1000120.
2009: Gehring Niels H; Lamprinaki Styliani; Kulozik Andreas E; Hentze Matthias W
Disassembly of exon junction complexes by PYM.
Cell 2009;137(3):536-48.
2009: Casanovas Guillem; Mleczko-Sanecka Katarzyna; Altamura Sandro; Hentze Matthias W; Muckenthaler Martina U
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):471-80.
2009: Ferring-Appel Dunja; Hentze Matthias W; Galy Bruno
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism.
Blood 2009;113(3):679-87.
2009: Beilharz Traude H; Humphreys David T; Clancy Jennifer L; Thermann Rolf; Martin David I K; Hentze Matthias W; Preiss Thomas
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.
PloS one 2009;4(8):e6783.
2008: Thoma Christian; Fraterman Sven; Gentzel Marc; Wilm Matthias; Hentze Matthias W
Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.
RNA (New York, N.Y.) 2008;14(8):1579-89.
2008: Verga Falzacappa Maria Vittoria; Casanovas Guillem; Hentze Matthias W; Muckenthaler Martina U
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.
Journal of molecular medicine (Berlin, Germany) 2008;86(5):531-40.
2008: Ivanov Pavel V; Gehring Niels H; Kunz Joachim B; Hentze Matthias W; Kulozik Andreas E
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
The EMBO journal 2008;27(5):736-47.
2008: Danckwardt Sven; Hentze Matthias W; Kulozik Andreas E
3' end mRNA processing: molecular mechanisms and implications for health and disease.
The EMBO journal 2008;27(3):482-98.
2008: Vujic Spasic Maja; Kiss Judit; Herrmann Thomas; Galy Bruno; Martinache Stefanie; Stolte Jens; Gröne Hermann-Josef; Stremmel Wolfgang; Hentze Matthias W; Muckenthaler Martina U
Hfe acts in hepatocytes to prevent hemochromatosis.
Cell metabolism 2008;7(2):173-8.
2008: Galy Bruno; Ferring-Appel Dunja; Kaden Sylvia; Gröne Hermann-Josef; Hentze Matthias W
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.
Cell metabolism 2008;7(1):79-85.
2008: Gehring Niels H; Hentze Matthias W; Kulozik Andreas E
Tethering assays to investigate nonsense-mediated mRNA decay activating proteins.
Methods in enzymology 2008;448():467-82.
2008: Muckenthaler Martina U; Galy Bruno; Hentze Matthias W
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.
Annual review of nutrition 2008;28():197-213.
2008: Castoldi Mirco; Schmidt Sabine; Benes Vladimir; Hentze Matthias W; Muckenthaler Martina U
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes.
Nature protocols 2008;3(2):321-9.
2007: Till Susanne; Lejeune Erwan; Thermann Rolf; Bortfeld Miriam; Hothorn Michael; Enderle Daniel; Heinrich Constanze; Hentze Matthias W; Ladurner Andreas G
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
Nature structural & molecular biology 2007;14(10):897-903.
2007: Castoldi Mirco; Benes Vladimir; Hentze Matthias W; Muckenthaler Martina U
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes.
Methods (San Diego, Calif.) 2007;43(2):146-52.
2007: Percy Melanie J; Sanchez Mayka; Swierczek Sabina; McMullin Mary Frances; Mojica-Henshaw Mariluz P; Muckenthaler Martina U; Prchal Josef T; Hentze Matthias W
Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
Blood 2007;110(7):2776-7.
2007: Fillebeen Carine; Muckenthaler Martina; Andriopoulos Bill; Bisaillon Martin; Mounir Zineb; Hentze Matthias W; Koromilas Antonis E; Pantopoulos Kostas
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.
Journal of hepatology 2007;47(1):12-22.
2007: Thermann Rolf; Hentze Matthias W
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.
Nature 2007;447(7146):875-8.
2007: Danckwardt Sven; Kaufmann Isabelle; Gentzel Marc; Foerstner Konrad U; Gantzert Anne-Susan; Gehring Niels H; Neu-Yilik Gabriele; Bork Peer; Keller Walter; Wilm Matthias; Hentze Matthias W; Kulozik Andreas E
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.
The EMBO journal 2007;26(11):2658-69.
2007: Sanchez Mayka; Galy Bruno; Muckenthaler Martina U; Hentze Matthias W
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.
Nature structural & molecular biology 2007;14(5):420-6.
2007: Vujic Spasic Maja; Kiss Judit; Herrmann Thomas; Kessler Regina; Stolte Jens; Galy Bruno; Rathkolb Birgit; Wolf Eckhard; Stremmel Wolfgang; Hentze Matthias W; Muckenthaler Martina U
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.
Blood 2007;109(10):4511-7.
2007: Ludwiczek Susanne; Theurl Igor; Muckenthaler Martina U; Jakab Martin; Mair Sabine M; Theurl Milan; Kiss Judit; Paulmichl Markus; Hentze Matthias W; Ritter Markus; Weiss Guenter
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1.
Nature medicine 2007;13(4):448-54.
2007: Verga Falzacappa Maria Vittoria; Vujic Spasic Maja; Kessler Regina; Stolte Jens; Hentze Matthias W; Muckenthaler Martina U
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.
Blood 2007;109(1):353-8.
2007: Gebauer Fátima; Hentze Matthias W
Studying translational control in Drosophila cell-free systems.
Methods in enzymology 2007;429():23-33.
2007: Sanchez Mayka; Galy Bruno; Hentze Matthias W; Muckenthaler Martina U
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays.
Nature protocols 2007;2(8):2033-42.
2007: Viegas Marcelo H; Gehring Niels H; Breit Stephen; Hentze Matthias W; Kulozik Andreas E
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway.
Nucleic acids research 2007;35(13):4542-51.
2007: Mihailovich Marija; Thermann Rolf; Grohovaz Fabio; Hentze Matthias W; Zacchetti Daniele
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.
Nucleic acids research 2007;35(9):2975-85.
2006: Boelz Stephanie; Neu-Yilik Gabriele; Gehring Niels H; Hentze Matthias W; Kulozik Andreas E
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.
Biochemical and biophysical research communications 2006;349(1):186-91.
2006: Galy Bruno; Hölter Sabine M; Klopstock Thomas; Ferring Dunja; Becker Lore; Kaden Sylvia; Wurst Wolfgang; Gröne Hermann-Josef; Hentze Matthias W
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse.
Nature genetics 2006;38(9):967-9; discussion 969-70.
2006: Sanchez Mayka; Galy Bruno; Dandekar Thomas; Bengert Peter; Vainshtein Yevhen; Stolte Jens; Muckenthaler Martina U; Hentze Matthias W
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.
The Journal of biological chemistry 2006;281(32):22865-74.
2006: Holbrook Jill A; Neu-Yilik Gabriele; Gehring Niels H; Kulozik Andreas E; Hentze Matthias W
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay.
EMBO reports 2006;7(7):722-6.
2006: Corna Gianfranca; Galy Bruno; Hentze Matthias W; Cairo Gaetano
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice.
Journal of molecular medicine (Berlin, Germany) 2006;84(7):551-60.
2006: Kunz Joachim B; Neu-Yilik Gabriele; Hentze Matthias W; Kulozik Andreas E; Gehring Niels H
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
RNA (New York, N.Y.) 2006;12(6):1015-22.
2006: Danckwardt S; Hartmann K; Katz B; Hentze M W; Levy Y; Eichele R; Deutsch V; Kulozik A E; Ben-Tal O
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1078-85.
2006: Castoldi Mirco; Schmidt Sabine; Benes Vladimir; Noerholm Mikkel; Kulozik Andreas E; Hentze Matthias W; Muckenthaler Martina U
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA).
RNA (New York, N.Y.) 2006;12(5):913-20.
2006: Mok Henry; Mlodnicka Agnieszka E; Hentze Matthias W; Muckenthaler Martina; Schumacher Armin
The molecular circuitry regulating the switch between iron deficiency and overload in mice.
The Journal of biological chemistry 2006;281(12):7946-51.
2006: Chekulaeva Marina; Hentze Matthias W; Ephrussi Anne
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
Cell 2006;124(3):521-33.
2006: Duncan Kent; Grskovic Marica; Strein Claudia; Beckmann Karsten; Niggeweg Ricarda; Abaza Irina; Gebauer Fátima; Wilm Matthias; Hentze Matthias W
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation.
Genes & development 2006;20(3):368-79.
2006: Stockklausner Clemens; Breit Stephen; Neu-Yilik Gabriele; Echner Nicole; Hentze Matthias W; Kulozik Andreas E; Gehring Niels H
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).
Nucleic acids research 2006;34(8):2355-63.
2006: Danckwardt Sven; Hartmann Kathrin; Gehring Niels H; Hentze Matthias W; Kulozik Andreas E
3' end processing of the prothrombin mRNA in thrombophilia.
Acta haematologica 2006;115(3-4):192-7.
2005: Galy Bruno; Ferring Dunja; Hentze Matthias W
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.
Genesis (New York, N.Y. : 2000) 2005;43(4):181-8.
2005: Gehring Niels H; Kunz Joachim B; Neu-Yilik Gabriele; Breit Stephen; Viegas Marcelo H; Hentze Matthias W; Kulozik Andreas E
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
Molecular cell 2005;20(1):65-75.
2005: Galy Bruno; Ferring Dunja; Minana Belen; Bell Oliver; Janser Heinz G; Muckenthaler Martina; Schümann Klaus; Hentze Matthias W
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).
Blood 2005;106(7):2580-9.
2005: Hundsdoerfer Patrick; Thoma Christian; Hentze Matthias W
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13421-6.
2005: Beckmann Karsten; Grskovic Marica; Gebauer Fátima; Hentze Matthias W
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila.
Cell 2005;122(4):529-40.
2005: Fillebeen Carine; Rivas-Estilla Ana Maria; Bisaillon Martin; Ponka Prem; Muckenthaler Martina; Hentze Matthias W; Koromilas Antonis E; Pantopoulos Kostas
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
The Journal of biological chemistry 2005;280(10):9049-57.
2004: Gebauer Fátima; Hentze Matthias W
Molecular mechanisms of translational control.
Nature reviews. Molecular cell biology 2004;5(10):827-35.
2004: Thoma Christian; Bergamini Giovanna; Galy Bruno; Hundsdoerfer Patrick; Hentze Matthias W
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP.
Molecular cell 2004;15(6):925-35.
2004: Muckenthaler Martina U; Rodrigues Pedro; Macedo Maria G; Minana Belen; Brennan Karen; Cardoso Elsa M; Hentze Matthias W; de Sousa Maria
Molecular analysis of iron overload in beta2-microglobulin-deficient mice.
Blood cells, molecules & diseases 2004;33(2):125-31.
2004: Holbrook Jill A; Neu-Yilik Gabriele; Hentze Matthias W; Kulozik Andreas E
Nonsense-mediated decay approaches the clinic.
Nature genetics 2004;36(8):801-8.
2004: Galy Bruno; Ferring Dunja; Benesova Monika; Benes Vladimir; Hentze Matthias W
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.
RNA (New York, N.Y.) 2004;10(7):1019-25.
2004: Danckwardt Sven; Gehring Niels H; Neu-Yilik Gabriele; Hundsdoerfer Patrick; Pforsich Margit; Frede Ute; Hentze Matthias W; Kulozik Andreas E
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.
Blood 2004;104(2):428-35.
2004: Roy Cindy N; Custodio Angel O; de Graaf Jos; Schneider Susanne; Akpan Imo; Montross Lynne K; Sanchez Mayka; Gaudino Alessandro; Hentze Matthias W; Andrews Nancy C; Muckenthaler Martina U
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
Nature genetics 2004;36(5):481-5.
2004: Bonnah Robert A; Muckenthaler Martina U; Carlson Hanqian; Minana Belen; Enns Caroline A; Hentze Matthias W; So Magdalene
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.
Cellular microbiology 2004;6(5):473-84.
2004: Hentze Matthias W; Muckenthaler Martina U; Andrews Nancy C
Balancing acts: molecular control of mammalian iron metabolism.
Cell 2004;117(3):285-97.
2004: Wang Jian; Chen Guohua; Muckenthaler Martina; Galy Bruno; Hentze Matthias W; Pantopoulos Kostas
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.
Molecular and cellular biology 2004;24(3):954-65.
2004: Herrmann Thomas; Muckenthaler Martina; van der Hoeven Frank; Brennan Karen; Gehrke Sven G; Hubert Nadia; Sergi Consolato; Gröne Hermann-Josef; Kaiser Iris; Gosch Isabella; Volkmann Martin; Riedel Hans-Dieter; Hentze Matthias W; Stewart A Francis; Stremmel Wolfgang
Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.
Journal of molecular medicine (Berlin, Germany) 2004;82(1):39-48.
2004: Neu-Yilik Gabriele; Gehring Niels H; Hentze Matthias W; Kulozik Andreas E
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.
Genome biology 2004;5(4):218.
2004: Thoma Christian; Ostareck-Lederer Antje; Hentze Matthias W
A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells.
Methods in molecular biology (Clifton, N.J.) 2004;257():171-80.
2004: Baron-Benhamou Julie; Gehring Niels H; Kulozik Andreas E; Hentze Matthias W
Using the lambdaN peptide to tether proteins to RNAs.
Methods in molecular biology (Clifton, N.J.) 2004;257():135-54.
2003: Preiss Thomas; Baron-Benhamou Julie; Ansorge Wilhelm; Hentze Matthias W
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.
Nature structural biology 2003;10(12):1039-47.
2003: Ohnishi Tetsuo; Yamashita Akio; Kashima Isao; Schell Thomas; Anders Kirk R; Grimson Andrew; Hachiya Takahisa; Hentze Matthias W; Anderson Philip; Ohno Shigeo
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
Molecular cell 2003;12(5):1187-200.
2003: Grskovic Marica; Hentze Matthias W; Gebauer Fátima
A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA.
The EMBO journal 2003;22(20):5571-81.
2003: Schell Thomas; Köcher Thomas; Wilm Matthias; Seraphin Bertrand; Kulozik Andreas E; Hentze Matthias W
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.
The Biochemical journal 2003;373(Pt 3):775-83.
2003: Baron-Benhamou Julie; Fortes Puri; Inada Toshifumi; Preiss Thomas; Hentze Matthias W
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast.
RNA (New York, N.Y.) 2003;9(6):654-62.
2003: Gebauer Fátima; Grskovic Marica; Hentze Matthias W
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA.
Molecular cell 2003;11(5):1397-404.
2003: Muckenthaler Martina; Roy Cindy N; Custodio Angel O; Miñana Belén; deGraaf Jos; Montross Lynne K; Andrews Nancy C; Hentze Matthias W
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
Nature genetics 2003;34(1):102-7.
2003: Muckenthaler Martina; Richter Alexandra; Gunkel Niki; Riedel Dieter; Polycarpou-Schwarz Maria; Hentze Sabine; Falkenhahn Mechthild; Stremmel Wolfgang; Ansorge Wilhelm; Hentze Matthias W
Relationships and distinctions in iron-regulatory networks responding to interrelated signals.
Blood 2003;101(9):3690-8.
2003: Gehring Niels H; Neu-Yilik Gabriele; Schell Thomas; Hentze Matthias W; Kulozik Andreas E
Y14 and hUpf3b form an NMD-activating complex.
Molecular cell 2003;11(4):939-49.
2003: Thompson Khristy; Menzies Sharon; Muckenthaler Martina; Torti Frank M; Wood Teresa; Torti Suzy V; Hentze Matthias W; Beard John; Connor James
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.
Journal of neuroscience research 2003;71(1):46-63.
2002: Hubert Nadia; Hentze Matthias W
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12345-50.
2002: Schümann Klaus; Borch-Iohnsen Berit; Hentze Matthias W; Marx Joannes J M
Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board.
The American journal of clinical nutrition 2002;76(3):499-500.
2002: Ostareck-Lederer Antje; Ostareck Dirk H; Cans Christophe; Neubauer Gitte; Bomsztyk Karol; Superti-Furga Giulio; Hentze Matthias W
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Molecular and cellular biology 2002;22(13):4535-43.
2002: Danckwardt Sven; Neu-Yilik Gabriele; Thermann Rolf; Frede Ute; Hentze Matthias W; Kulozik Andreas E
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay.
Blood 2002;99(5):1811-6.
2002: Brocke Katja S; Neu-Yilik Gabriele; Gehring Niels H; Hentze Matthias W; Kulozik Andreas E
The human intronless melanocortin 4-receptor gene is NMD insensitive.
Human molecular genetics 2002;11(3):331-5.
2002: Schell Thomas; Kulozik Andreas E; Hentze Matthias W
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.
Genome biology 2002;3(3):REVIEWS1006.
2001: Gunshin H; Allerson C R; Polycarpou-Schwarz M; Rofts A; Rogers J T; Kishi F; Hentze M W; Rouault T A; Andrews N C; Hediger M A
Iron-dependent regulation of the divalent metal ion transporter.
FEBS letters 2001;509(2):309-16.
2001: Gebauer F; Hentze M W
Fertility facts: male and female germ cell development requires translational control by CPEB.
Molecular cell 2001;8(2):247-9.
2001: Hentze M W
Protein synthesis. Believe it or not-translation in the nucleus.
Science (New York, N.Y.) 2001;293(5532):1058-9.
2001: Gehring N H; Frede U; Neu-Yilik G; Hundsdoerfer P; Vetter B; Hentze M W; Kulozik A E
Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia.
Nature genetics 2001;28(4):389-92.
2001: Mueller S; Pantopoulos K; Hübner C A; Stremmel W; Hentze M W
IRP1 activation by extracellular oxidative stress in the perfused rat liver.
The Journal of biological chemistry 2001;276(25):23192-6.
2001: Neu-Yilik G; Gehring N H; Thermann R; Frede U; Hentze M W; Kulozik A E
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.
The EMBO journal 2001;20(3):532-40.
2001: De Gregorio E; Baron J; Preiss T; Hentze M W
Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.
RNA (New York, N.Y.) 2001;7(1):106-13.
2001: Ostareck D H; Ostareck-Lederer A; Shatsky I N; Hentze M W
Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining.
Cell 2001;104(2):281-90.
2001: Gebauer F; Ostareck D H; Ostareck-Lederer A; Grskovic M; Hentze M W
Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?
Cold Spring Harbor symposia on quantitative biology 2001;66():329-36.
2000: Bergamini G; Preiss T; Hentze M W
Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system.
RNA (New York, N.Y.) 2000;6(12):1781-90.
2000: Hentze M W; Izaurralde E; Séraphin B
A new era for the RNA world. Conference: RNA 2000.
EMBO reports 2000;1(5):394-8.
2000: Fortes P; Inada T; Preiss T; Hentze M W; Mattaj I W; Sachs A B
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation.
Molecular cell 2000;6(1):191-6.
2000: Volkmann M; Schiff J H; Hör M; Hentze M W; Fiehn W; Merkt J
[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]
Der Internist 2000;41(4):381-4.
2000: Castagnetti S; Hentze M W; Ephrussi A; Gebauer F
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.
Development (Cambridge, England) 2000;127(5):1063-8.
1999: Riedel H D; Muckenthaler M U; Gehrke S G; Mohr I; Brennan K; Herrmann T; Fitscher B A; Hentze M W; Stremmel W
HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.
Blood 1999;94(11):3915-21.
1999: Gebauer F; Corona D F; Preiss T; Becker P B; Hentze M W
Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail.
The EMBO journal 1999;18(21):6146-54.
1999: Preiss T; Hentze M W
From factors to mechanisms: translation and translational control in eukaryotes.
Current opinion in genetics & development 1999;9(5):515-21.
1999: De Gregorio E; Preiss T; Hentze M W
Translation driven by an eIF4G core domain in vivo.
The EMBO journal 1999;18(17):4865-74.
1999: Gegout V; Schlegl J; Schläger B; Hentze M W; Reinbolt J; Ehresmann B; Ehresmann C; Romby P
Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting.
The Journal of biological chemistry 1999;274(21):15052-8.
1999: Gehring N H; Hentze M W; Pantopoulos K
Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress.
The Journal of biological chemistry 1999;274(10):6219-25.
1999: Hentze M W; Kulozik A E
A perfect message: RNA surveillance and nonsense-mediated decay.
Cell 1999;96(3):307-10.
1999: Paraskeva E; Gray N K; Schläger B; Wehr K; Hentze M W
Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements.
Molecular and cellular biology 1999;19(1):807-16.
1998: Ostareck-Lederer A; Ostareck D H; Hentze M W
Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
Trends in biochemical sciences 1998;23(11):409-11.
1998: Preiss T; Muckenthaler M; Hentze M W
Poly(A)-tail-promoted translation in yeast: implications for translational control.
RNA (New York, N.Y.) 1998;4(11):1321-31.
1998: Muckenthaler M; Gray N K; Hentze M W
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.
Molecular cell 1998;2(3):383-8.
1998: Pantopoulos K; Hentze M W
Activation of iron regulatory protein-1 by oxidative stress in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10559-63.
1998: De Gregorio E; Preiss T; Hentze M W
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent.
RNA (New York, N.Y.) 1998;4(7):828-36.
1998: Muckenthaler M; Gunkel N; Frishman D; Cyrklaff A; Tomancak P; Hentze M W
Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans.
European journal of biochemistry / FEBS 1998;254(2):230-7.
1998: Thermann R; Neu-Yilik G; Deters A; Frede U; Wehr K; Hagemeier C; Hentze M W; Kulozik A E
Binary specification of nonsense codons by splicing and cytoplasmic translation.
The EMBO journal 1998;17(12):3484-94.
1998: Preiss T; Hentze M W
Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast.
Nature 1998;392(6675):516-20.
1998: Gebauer F; Merendino L; Hentze M W; Valcárcel J
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.
RNA (New York, N.Y.) 1998;4(2):142-50.
1998: Paraskeva E; Atzberger A; Hentze M W
A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):951-6.
1998: Dandekar T; Beyer K; Bork P; Kenealy M R; Pantopoulos K; Hentze M; Sonntag-Buck V; Flouriot G; Gannon F; Schreiber S
Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches.
Bioinformatics (Oxford, England) 1998;14(3):271-8.
1997: Schlegl J; Gegout V; Schläger B; Hentze M W; Westhof E; Ehresmann C; Ehresmann B; Romby P
Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.
RNA (New York, N.Y.) 1997;3(10):1159-72.
1997: Muckenthaler M; Gunkel N; Stripecke R; Hentze M W
Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association.
RNA (New York, N.Y.) 1997;3(9):983-95.
1997: Ostareck D H; Ostareck-Lederer A; Wilm M; Thiele B J; Mann M; Hentze M W
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.
Cell 1997;89(4):597-606.
1997: Pantopoulos K; Mueller S; Atzberger A; Ansorge W; Stremmel W; Hentze M W
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
The Journal of biological chemistry 1997;272(15):9802-8.
1997: Hentze M W
eIF4G: a multipurpose ribosome adapter?
Science (New York, N.Y.) 1997;275(5299):500-1.
1997: Weiss G; Bogdan C; Hentze M W
Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):420-5.
1997: Muckenthaler M; Hentze M W
Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins.
Progress in molecular and subcellular biology 1997;18():93-115.
1996: Hentze M W; Kühn L C
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8175-82.
1996: Frishman D; Hentze M W
Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships.
European journal of biochemistry / FEBS 1996;239(1):197-200.
1996: Pantopoulos K; Weiss G; Hentze M W
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways.
Molecular and cellular biology 1996;16(7):3781-8.
1996: Paraskeva E; Hentze M W
Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1.
FEBS letters 1996;389(1):40-3.
1996: Gray N K; Pantopoulos K; Dandekar T; Ackrell B A; Hentze M W
Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4925-30.
1995: Pantopoulos K; Hentze M W
Rapid responses to oxidative stress mediated by iron regulatory protein.
The EMBO journal 1995;14(12):2917-24.
1995: Hentze M W
Translational regulation: versatile mechanisms for metabolic and developmental control.
Current opinion in cell biology 1995;7(3):393-8.
1995: Pantopoulos K; Gray N K; Hentze M W
Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.
RNA (New York, N.Y.) 1995;1(2):155-63.
1995: Dandekar T; Hentze M W
Finding the hairpin in the haystack: searching for RNA motifs.
Trends in genetics : TIG 1995;11(2):45-50.
1995: Pantopoulos K; Hentze M W
Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1267-71.
1994: Johansson H E; Belsham G J; Sproat B S; Hentze M W
Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides.
Nucleic acids research 1994;22(22):4591-8.
1994: Stripecke R; Oliveira C C; McCarthy J E; Hentze M W
Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.
Molecular and cellular biology 1994;14(9):5898-909.
1994: Weiss G; Werner-Felmayer G; Werner E R; Grünewald K; Wachter H; Hentze M W
Iron regulates nitric oxide synthase activity by controlling nuclear transcription.
The Journal of experimental medicine 1994;180(3):969-76.
1994: Gray N K; Hentze M W
Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.
The EMBO journal 1994;13(16):3882-91.
1994: Gray N K; Hentze M W
Regulation of protein synthesis by mRNA structure.
Molecular biology reports 1994;19(3):195-200.
1994: Pantopoulos K; Weiss G; Hentze M W
Nitric oxide and the post-transcriptional control of cellular iron traffic.
Trends in cell biology 1994;4(3):82-6.
1994: Hentze M W
Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?
Trends in biochemical sciences 1994;19(3):101-3.
1994: Pantopoulos K; Johansson H E; Hentze M W
The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.
Progress in nucleic acid research and molecular biology 1994;48():181-238.
1994: Hentze M W
Translational control by iron-responsive elements.
Advances in experimental medicine and biology 1994;356():119-26.
1994: Weiss G; Goossen B; Doppler W; Fuchs D; Pantopoulos K; Werner-Felmayer G; Grünewald K; Wachter H; Hentze M W
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.
Advances in experimental medicine and biology 1994;356():133-9.
1993: Gray N K; Quick S; Goossen B; Constable A; Hirling H; Kühn L C; Hentze M W
Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch.
European journal of biochemistry / FEBS 1993;218(2):657-67.
1993: Melefors O; Hentze M W
Iron regulatory factor--the conductor of cellular iron regulation.
Blood reviews 1993;7(4):251-8.
1993: Oliveira C C; Goossen B; Zanchin N I; McCarthy J E; Hentze M W; Stripecke R
Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae.
Nucleic acids research 1993;21(23):5316-22.
1993: Weiss G; Goossen B; Doppler W; Fuchs D; Pantopoulos K; Werner-Felmayer G; Wachter H; Hentze M W
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.
The EMBO journal 1993;12(9):3651-7.
1993: Melefors O; Goossen B; Johansson H E; Stripecke R; Gray N K; Hentze M W
Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.
The Journal of biological chemistry 1993;268(8):5974-8.
1993: Melefors O; Hentze M W
Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(2):85-90.
1992: Stripecke R; Hentze M W
Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro.
Nucleic acids research 1992;20(21):5555-64.
1992: Constable A; Quick S; Gray N K; Hentze M W
Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4554-8.
1992: Goossen B; Hentze M W
Position is the critical determinant for function of iron-responsive elements as translational regulators.
Molecular and cellular biology 1992;12(5):1959-66.
1991: Dandekar T; Stripecke R; Gray N K; Goossen B; Constable A; Johansson H E; Hentze M W
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
The EMBO journal 1991;10(7):1903-9.
1991: Hentze M W; Argos P
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
Nucleic acids research 1991;19(8):1739-40.
1991: Johansson H E; De Groot N; Hochberg A A; Hentze M W
Effect of heparin contained in preparations of small cytoplasmic RNAs on cell-free translation.
The Journal of biological chemistry 1991;266(3):1921-5.
1991: Hentze M W
Translational regulation of ferritin biosynthesis by iron: a review.
Current studies in hematology and blood transfusion 1991;(58):115-26.
1990: Goossen B; Caughman S W; Harford J B; Klausner R D; Hentze M W
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.
The EMBO journal 1990;9(12):4127-33.
1990: Hentze M W
Overcoming inhibitions. Translational Control sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, September 13-17, 1989.
The New biologist 1990;2(1):33-6.
1990: Hentze M W; Goossen B; Caughman S W
Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.
Molecular biology reports 1990;14(2-3):61.
1989: Haile D J; Hentze M W; Rouault T A; Harford J B; Klausner R D
Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.
Molecular and cellular biology 1989;9(11):5055-61.
1989: Hentze M W; Seuanez H N; O'Brien S J; Harford J B; Klausner R D
Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.
Nucleic acids research 1989;17(15):6103-8.
1989: Rouault T A; Hentze M W; Haile D J; Harford J B; Klausner R D
The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5768-72.
1989: Koeller D M; Casey J L; Hentze M W; Gerhardt E M; Chan L N; Klausner R D; Harford J B
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3574-8.
1989: Hentze M W; Rouault T A; Harford J B; Klausner R D
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Science (New York, N.Y.) 1989;244(4902):357-9.
1988: Hentze M W; Caughman S W; Casey J L; Koeller D M; Rouault T A; Harford J B; Klausner R D
A model for the structure and functions of iron-responsive elements.
Gene 1988;72(1-2):201-8.
1988: Caughman S W; Hentze M W; Rouault T A; Harford J B; Klausner R D
The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.
The Journal of biological chemistry 1988;263(35):19048-52.
1988: Rouault T A; Hentze M W; Caughman S W; Harford J B; Klausner R D
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.
Science (New York, N.Y.) 1988;241(4870):1207-10.
1988: Casey J L; Hentze M W; Koeller D M; Caughman S W; Rouault T A; Klausner R D; Harford J B
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
Science (New York, N.Y.) 1988;240(4854):924-8.
1987: Hentze M W; Caughman S W; Rouault T A; Barriocanal J G; Dancis A; Harford J B; Klausner R D
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
Science (New York, N.Y.) 1987;238(4833):1570-3.
1987: Hentze M W; Rouault T A; Caughman S W; Dancis A; Harford J B; Klausner R D
A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6730-4.
1987: Rouault T A; Hentze M W; Dancis A; Caughman W; Harford J B; Klausner R D
Influence of altered transcription on the translational control of human ferritin expression.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6335-9.

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