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Morten Hentzer

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Morten T Rybtke; Bradley R Borlee; Michael Givskov; Morten Hentzer; Yasuhiko Irie; Keiji Murakami; Thomas E Nielsen; Matthew R Parsek; Tim Tolker-Nielsen
Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.
Robert Sautter; Lisa Schneper; Tina Wassermann; Søren Molin; Dennis E Ohman; Damaris Ramos; Oana Ciofu; Caroline A Devries; Morten Hentzer; Arne Heydorn; Niels Høiby; Arsalan Kharazmi; Chong-Lek Koh; Kalai Mathee
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.
Christian Garde; Thomas Bjarnsholt; Michael Givskov; Tim Holm Jakobsen; Morten Hentzer; Anetta Claussen; Kim Sneppen; Jesper Ferkinghoff-Borg; Thomas Sams
Quorum sensing regulation in Aeromonas hydrophila.

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2012: Morten T Rybtke; Bradley R Borlee; Michael Givskov; Morten Hentzer; Yasuhiko Irie; Keiji Murakami; Thomas E Nielsen; Matthew R Parsek; Tim Tolker-Nielsen
Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.
Applied and environmental microbiology 2012;78(15):5060-9.
2012: Robert Sautter; Lisa Schneper; Tina Wassermann; Søren Molin; Dennis E Ohman; Damaris Ramos; Oana Ciofu; Caroline A Devries; Morten Hentzer; Arne Heydorn; Niels Høiby; Arsalan Kharazmi; Chong-Lek Koh; Kalai Mathee
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.
Gene 2012;498(2):242-53.
2010: Christian Garde; Thomas Bjarnsholt; Michael Givskov; Tim Holm Jakobsen; Morten Hentzer; Anetta Claussen; Kim Sneppen; Jesper Ferkinghoff-Borg; Thomas Sams
Quorum sensing regulation in Aeromonas hydrophila.
Journal of molecular biology 2010;396(4):849-57.
2009: Liang Yang; Morten Theil Rybtke; Tim Holm Jakobsen; Morten Hentzer; Thomas Bjarnsholt; Michael Givskov; Tim Tolker-Nielsen
Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.
Antimicrobial agents and chemotherapy 2009;53(6):2432-43.
2007: Nadine Hoffmann; Baoleri Lee; Morten Hentzer; Thomas Bovbjerg Rasmussen; Zhijun Song; Helle Krogh Johansen; Michael Givskov; Niels Høiby
Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice.
Antimicrobial agents and chemotherapy 2007;51(10):3677-87.
2006: Joshua D Shrout; David L Chopp; Collin L Just; Morten Hentzer; Michael Givskov; Matthew R Parsek
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional.
Molecular microbiology 2006;62(5):1264-77.
2006: Kerstin Schreiber; Nelli Boes; Martin Eschbach; Lothar Jaensch; Jürgen Wehland; Thomas Bjarnsholt; Michael Givskov; Morten Hentzer; Max Schobert
Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein.
Journal of bacteriology 2006;188(2):659-68.
2005: Thomas Bjarnsholt; Peter Østrup Jensen; Thomas Bovbjerg Rasmussen; Lars Christophersen; Henrik Calum; Morten Hentzer; Hans Petter Hougen; Jørgen Rygaard; Claus Moser; Leo Eberl; Niels Høiby; Michael Givskov
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections.
Microbiology (Reading, England) 2005;151(Pt 12):3873-80.
2005: Alessandra Bragonzi; Dieter Worlitzsch; Gerald B Pier; Petra Timpert; Martina Ulrich; Morten Hentzer; Jens Bo Andersen; Michael Givskov; Massimo Conese; Gerd Doring
Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.
The Journal of infectious diseases 2005;192(3):410-9.
2005: Thomas Bovbjerg Rasmussen; Mette E Skindersoe; Thomas Bjarnsholt; Richard K Phipps; Kathrine B Christensen; Peter Ostrup Jensen; Jens Bo Andersen; Birgit Koch; Thomas O Larsen; Morten Hentzer; Leo Eberl; Niels Hoiby; Michael Givskov
Identity and effects of quorum-sensing inhibitors produced by Penicillium species.
Microbiology (Reading, England) 2005;151(Pt 5):1325-40.
2005: Nadine Hoffmann; Thomas Bovbjerg Rasmussen; Peter Østrup Jensen; Charlotte Stub; Morten Hentzer; Søren Molin; Oana Ciofu; Michael Givskov; Helle Krogh Johansen; Niels Høiby
Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.
Infection and immunity 2005;73(4):2504-14.
2005: Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Mette E Skindersoe; Morten Hentzer; Peter Kristoffersen; Manuela Köte; John Nielsen; Leo Eberl; Michael Givskov
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.
Journal of bacteriology 2005;187(5):1799-814.
2005: Thomas Bjarnsholt; Peter Østrup Jensen; Mette Burmølle; Morten Hentzer; Janus A J Haagensen; Hans Petter Hougen; Henrik Calum; Kit G Madsen; Claus Moser; Søren Molin; Niels Høiby; Michael Givskov
Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent.
Microbiology (Reading, England) 2005;151(Pt 2):373-83.
2004: Thomas Danhorn; Morten Hentzer; Michael Givskov; Matthew R Parsek; Clay Fuqua
Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system.
Journal of bacteriology 2004;186(14):4492-501.
2004: Andres Plata Stapper; Giri Narasimhan; Dennis Ohman; Johnny Barakat; Morten Hentzer; Søren Molin; Arsalan Kharazmi; Niels Høiby; Kalai Mathee
Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation.
Journal of medical microbiology 2004;53(Pt 7):679-90.
2004: H Wu; Zhijun Song; Morten Hentzer; Jens Bo Andersen; Søren Molin; Michael Givskov; Niels Høiby
Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice.
The Journal of antimicrobial chemotherapy 2004;53(6):1054-61.
2004: Niels Bagge; Martin Schuster; Morten Hentzer; Oana Ciofu; Michael Givskov; Everett Peter Greenberg; Niels Høiby
Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Antimicrobial agents and chemotherapy 2004;48(4):1175-87.
2004: Niels Bagge; Morten Hentzer; Jens Bo Andersen; Oana Ciofu; Michael Givskov; Niels Høiby
Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2004;48(4):1168-74.
2003: Catalina Arevalo-Ferro; Morten Hentzer; Gerold Reil; Angelika Görg; Staffan Kjelleberg; Michael Givskov; Kathrin Riedel; Leo Eberl
Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.
Environmental microbiology 2003;5(12):1350-69.
2003: Morten Hentzer; Michael Givskov
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.
The Journal of clinical investigation 2003;112(9):1300-7.
2003: Morten Hentzer; Hong Wu; Jens Bo Andersen; Kathrin Riedel; Thomas Bovbjerg Rasmussen; Niels Bagge; Naresh Kumar; Mark A Schembri; Zhijun Song; Peter Kristoffersen; Mike Manefield; J William Costerton; Søren Molin; Leo Eberl; Peter D Steinberg; Staffan Kjelleberg; Niels Høiby; Michael Givskov
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.
The EMBO journal 2003;22(15):3803-15.
2003: Morten Hentzer; Leo Eberl; John Nielsen; Michael Givskov
Quorum sensing : a novel target for the treatment of biofilm infections.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2003;17(4):241-50.
2002: Niels Bagge; Oana Ciofu; Morten Hentzer; Joan I A Campbell; Michael Givskov; Niels Høiby
Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
Antimicrobial agents and chemotherapy 2002;46(11):3406-11.
2002: David C Laux; Joy M Corson; Michael Givskov; Morten Hentzer; Annette Møller; Kathleen A Wosencroft; Joan C Olson; Karen A Krogfelt; Joanna B Goldberg; Paul S Cohen
Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA.
Microbiology (Reading, England) 2002;148(Pt 6):1709-23.
2002: Arne Heydorn; Bjarne K Ersbøll; Junichi Kato; Morten Hentzer; Matthew R Parsek; Tim Tolker-Nielsen; Michael Givskov; Søren Molin
Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.
Applied and environmental microbiology 2002;68(4):2008-17.
2002: J A Olsen; R Severinsen; Thomas Bovbjerg Rasmussen; Morten Hentzer; Michael Givskov; Jens Nielsen
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers.
Bioorganic & medicinal chemistry letters 2002;12(3):325-8.
2002: Morten Hentzer; Kathrin Riedel; Thomas Bovbjerg Rasmussen; Arne Heydorn; Jens Bo Andersen; Matthew R Parsek; Scott A Rice; Leo Eberl; Søren Molin; Niels Høiby; Staffan Kjelleberg; Michael Givskov
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.
Microbiology (Reading, England) 2002;148(Pt 1):87-102.
2001: Kathrin Riedel; Morten Hentzer; O Geisenberger; Birgit Huber; Anette Steidle; H Wu; Niels Høiby; Michael Givskov; Søren Molin; Leo Eberl
N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.
Microbiology (Reading, England) 2001;147(Pt 12):3249-62.
2001: Birgit Huber; Kathrin Riedel; Morten Hentzer; Arne Heydorn; Astrid Gotschlich; Michael Givskov; Søren Molin; Leo Eberl
The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility.
Microbiology (Reading, England) 2001;147(Pt 9):2517-28.
2001: Morten Hentzer; Gail M Teitzel; G J Balzer; Arne Heydorn; Søren Molin; Michael Givskov; Matthew R Parsek
Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function.
Journal of bacteriology 2001;183(18):5395-401.
2001: Jens Bo Andersen; Arne Heydorn; Morten Hentzer; Leo Eberl; O Geisenberger; Bjarke Bak Christensen; Søren Molin; Michael Givskov
gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication.
Applied and environmental microbiology 2001;67(2):575-85.
2001: Timothy S Charlton; Michael Givskov; R deNys; Jens Bo Andersen; Morten Hentzer; S Rice; Staffan Kjelleberg
Genetic and chemical tools for investigating signaling processes in biofilms.
Methods in enzymology 2001;336():108-28.
2000: Timothy S Charlton; Rocky de Nys; Andrew G Netting; Naresh Kumar; Morten Hentzer; Michael Givskov; Staffan Kjelleberg
A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm.
Environmental microbiology 2000;2(5):530-41.
2000: H Wu; Z Song; Morten Hentzer; Jens Bo Andersen; Arne Heydorn; Kalai Mathee; Claus Moser; Leo Eberl; Søren Molin; Niels Høiby; Michael Givskov
Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2481-93.
2000: Arne Heydorn; Bjarne K Ersbøll; Morten Hentzer; Matthew R Parsek; Michael Givskov; Søren Molin
Experimental reproducibility in flow-chamber biofilms.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2409-15.
2000: Arne Heydorn; AT Nielsen; Morten Hentzer; Claus Sternberg; Michael Givskov; Bjarne K Ersbøll; Søren Molin
Quantification of biofilm structures by the novel computer program COMSTAT.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2395-407.
2000: L F Bautista; A Aleksenko; Morten Hentzer; AL Santerre Henriksen; Jens Nielsen
Antisense silencing of the creA gene in Aspergillus nidulans.
Applied and environmental microbiology 2000;66(10):4579-81.