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John Hepler

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Chemicals & Drugs

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Publications

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Peishen Zhao; John R Hepler; Caroline Nunn; Suneela Ramineni; Peter Chidiac
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.
Christopher P Vellano; Joe B Blumer; Nicole E Brown; John R Hepler
Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.
Kelly L McCoy; Alan V Smrcka; Stephen F Traynelis; Christopher P Vellano; Stefka Gyoneva; John R Hepler
Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.

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All Publications

2013: Peishen Zhao; John R Hepler; Caroline Nunn; Suneela Ramineni; Peter Chidiac
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.
Journal of cellular biochemistry 2013;114(6):1414-23.
2013: Christopher P Vellano; Joe B Blumer; Nicole E Brown; John R Hepler
Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.
The Journal of biological chemistry 2013;288(5):3620-31.
2012: Kelly L McCoy; Alan V Smrcka; Stephen F Traynelis; Christopher P Vellano; Stefka Gyoneva; John R Hepler
Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.
Cellular signalling 2012;24(6):1351-60.
2011: Christopher P Vellano; John R Hepler; Ellen M Maher; Joe B Blumer
G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.
The Journal of biological chemistry 2011;286(44):38659-69.
2011: Christopher P Vellano; Sarah Emerson Lee; Serena M Dudek; John R Hepler
RGS14 at the interface of hippocampal signaling and synaptic plasticity.
Trends in pharmacological sciences 2011;32(11):666-74.
2011: Christopher P Vellano; Feng-Jue Shu; Suneela Ramineni; Cindee K Yates; Gregory G Tall; John R Hepler
Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.
Biochemistry 2011;50(5):752-62.
2010: Sarah Emerson Lee; Stephen B Simons; Scott A Heldt; Meilan Zhao; Jason P Schroeder; Christopher P Vellano; D Patrick Cowan; Suneela Ramineni; Cindee K Yates; Yue Feng; Yoland Smith; J David Sweatt; David Weinshenker; Kerry J Ressler; Serena M Dudek; John R Hepler
RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(39):16994-8.
2010: Kelly L McCoy; Stephen F Traynelis; John R Hepler
PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
Molecular pharmacology 2010;77(6):1005-15.
2010: Feng-jue Shu; Suneela Ramineni; John R Hepler
RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.
Cellular signalling 2010;22(3):366-76.
2007: Steven Gu; Janet He; Wing-Ting Ho; Suneela Ramineni; David M Thal; Ramanathan Natesh; John J G Tesmer; John R Hepler; Scott P Heximer
Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.
The Journal of biological chemistry 2007;282(45):33064-75.
2007: Katherine H. Pedone; John R Hepler
The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function.
The Journal of biological chemistry 2007;282(35):25199-212.
2007: Seena K Ajit; Suneela Ramineni; Wade Edris; Rachel A Hunt; Wah-Tung Hum; John R Hepler; Kathleen H Young
RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.
Cellular signalling 2007;19(4):723-30.
2007: Feng-jue Shu; Suneela Ramineni; Whitney Amyot; John R Hepler
Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.
Cellular signalling 2007;19(1):163-76.
2006: Karen L Neitzel; John R Hepler
Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling.
Seminars in cell & developmental biology 2006;17(3):383-9.
2006: Anju Anne Roy; Alessandra Baragli; Leah S Bernstein; John R Hepler; Terence E Hébert; Peter Chidiac
RGS2 interacts with Gs and adenylyl cyclase in living cells.
Cellular signalling 2006;18(3):336-48.
2006: Katherine B Hubbard; John R Hepler
Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins.
Cellular signalling 2006;18(2):135-50.
2005: John R Hepler
R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain.
Science's STKE : signal transduction knowledge environment 2005;2005(294):pe38.
2005: Chris Hague; Leah S Bernstein; Suneela Ramineni; Zhongjian Chen; Kenneth P Minneman; John R Hepler
Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.
The Journal of biological chemistry 2005;280(29):27289-95.
2005: Richard D Peavy; Katherine B Hubbard; Anthony Lau; R Brett Fields; Kaiming Xu; C Justin Lee; Terri T Lee; Kimberly Gernert; Thomas J Murphy; John R Hepler
Differential effects of Gq alpha, G14 alpha, and G15 alpha on vascular smooth muscle cell survival and gene expression profiles.
Molecular pharmacology 2005;67(6):2102-14.
2005: Olivier Nicole; Anna Goldshmidt; Cecily E Hamill; Scott D Sorensen; Aristide Sastre; Polina Lyuboslavsky; John R Hepler; Robert J McKeon; Stephen F Traynelis
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4319-29.
2005: John R Hepler; Wendy Cladman; Suneela Ramineni; Susanne Hollinger; Peter Chidiac
Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity.
Biochemistry 2005;44(14):5495-502.
2004: Candice E Junge; C Justin Lee; Katherine B Hubbard; Zhoabin Zhang; Jeffrey J Olson; John R Hepler; Daniel J Brat; Stephen F Traynelis
Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes.
Experimental neurology 2004;188(1):94-103.
2004: Leah S Bernstein; Suneela Ramineni; Chris Hague; Wendy Cladman; Peter Chidiac; Allan Levey; John R Hepler
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
The Journal of biological chemistry 2004;279(20):21248-56.
2004: Susanne Hollinger; John R Hepler
Methods for measuring RGS protein phosphorylation by G protein-regulated kinases.
Methods in molecular biology (Clifton, N.J.) 2004;237():205-19.
2004: Leah S Bernstein; Maurine E Linder; John R Hepler
Analysis of RGS protein palmitoylation.
Methods in molecular biology (Clifton, N.J.) 2004;237():195-204.
2003: Scott D Sorensen; Olivier Nicole; Richard D Peavy; Lisa M Montoya; C Justin Lee; Thomas J Murphy; Stephen F Traynelis; John R Hepler
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
Molecular pharmacology 2003;64(5):1199-209.
2003: John R Hepler
RGS protein and G protein interactions: a little help from their friends.
Molecular pharmacology 2003;64(3):547-9.
2003: Susanne Hollinger; Suneela Ramineni; John R Hepler
Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.
Biochemistry 2003;42(3):811-9.
2002: Susanne Hollinger; John R Hepler
Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.
Pharmacological reviews 2002;54(3):527-59.
2002: Peter Chidiac; Martha E Gadd; John R Hepler
Measuring RGS protein interactions with Gq alpha.
Methods in enzymology 2002;344():686-702.
2001: Susanne Hollinger; J B Taylor; E H Goldman; John R Hepler
RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.
Journal of neurochemistry 2001;79(5):941-9.
2001: M L Cunningham; Gary L Waldo; Susanne Hollinger; John R Hepler; T Kendall Harden
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
The Journal of biological chemistry 2001;276(8):5438-44.
2000: J J Rose; J B Taylor; J Shi; Mark Cockett; P G Jones; John R Hepler
RGS7 is palmitoylated and exists as biochemically distinct forms.
Journal of neurochemistry 2000;75(5):2103-12.
1999: Scott P Heximer; SP Srinivasa; Leah S Bernstein; J L Bernard; Maurine E Linder; John R Hepler; Kendall J Blumer
G protein selectivity is a determinant of RGS2 function.
The Journal of biological chemistry 1999;274(48):34253-9.
1999: John R Hepler
Emerging roles for RGS proteins in cell signalling.
Trends in pharmacological sciences 1999;20(9):376-82.
1998: Julie A Saugstad; Michael J Marino; J A Folk; John R Hepler; P Jeffrey Conn
RGS4 inhibits signaling by group I metabotropic glutamate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(3):905-13.
1997: Scott P Heximer; N Watson; Maurine E Linder; Kendall J Blumer; John R Hepler
RGS2/G0S8 is a selective inhibitor of Gqalpha function.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14389-93.
1996: John R Hepler; G H Biddlecome; C Kleuss; L A Camp; Hofmann Sandra; Elliott M Ross; Alfred G Gilman
Functional importance of the amino terminus of Gq alpha.
The Journal of biological chemistry 1996;271(1):496-504.
1994: R Taussig; W J Tang; John R Hepler; Alfred G Gilman
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
The Journal of biological chemistry 1994;269(8):6093-100.
1994: John R Hepler; Tohru Kozasa; Alfred G Gilman
Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells.
Methods in enzymology 1994;237():191-212.
1993: Tohru Kozasa; John R Hepler; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9176-80.
1993: John R Hepler; Tohru Kozasa; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.
The Journal of biological chemistry 1993;268(19):14367-75.
1993: Maurine E Linder; P Middleton; John R Hepler; R Taussig; Alfred G Gilman; Susanne M Mumby
Lipid modifications of G proteins: alpha subunits are palmitoylated.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3675-9.
1992: John R Hepler; Alfred G Gilman
G proteins.
Trends in biochemical sciences 1992;17(10):383-7.
1991: A V Smrcka; John R Hepler; K O Brown; Paul C Sternweis
Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
Science (New York, N.Y.) 1991;251(4995):804-7.