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Kithsiri Herath

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Genes & Molecular Sequences

Molecular Structure

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Publications

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Sheo B Singh; George K Abruzzo; Kithsiri B Herath; Jennifer Nielsen Kahn; Paul Mann; Mary Motyl
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.
Sheo B Singh; FRANCISCA VCICENTE; Hao Wang; Deborah L Zink; George K Abruzzo; Gerald F Bills; Javier Collado; S Galuska; RA Giacobbe; Antonio González del Val; Guy Harris; Kithsiri B Herath; Jennifer Nielsen Kahn; Jesus Martin; John G Ondeyka; Gonzalo Platas; Fernando Reyes; Terry Roemer; Deming Xu
Isolation, structure, and biological activity of Phaeofungin, a cyclic lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test.
Haihong Zhou; Rory J Rohm; Raymond Rosa; Sheng-Ping Wang; Kenny K Wong; Kithsiri B Herath; Brian K Hubbard; James Hubert; Douglas G Johns; Michael E Lassman; Wenyu Li; Theresa McLaughlin; Vivienne Mendoza; Stephen Previs; Thomas P Roddy
Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water.

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All Publications

2013: Sheo B Singh; George K Abruzzo; Kithsiri B Herath; Jennifer Nielsen Kahn; Paul Mann; Mary Motyl
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.
Bioorganic & medicinal chemistry letters 2013;23(11):3253-6.
2013: Sheo B Singh; FRANCISCA VCICENTE; Hao Wang; Deborah L Zink; George K Abruzzo; Gerald F Bills; Javier Collado; S Galuska; RA Giacobbe; Antonio González del Val; Guy Harris; Kithsiri B Herath; Jennifer Nielsen Kahn; Jesus Martin; John G Ondeyka; Gonzalo Platas; Fernando Reyes; Terry Roemer; Deming Xu
Isolation, structure, and biological activity of Phaeofungin, a cyclic lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test.
Journal of natural products 2013;76(3):334-45.
2012: Haihong Zhou; Rory J Rohm; Raymond Rosa; Sheng-Ping Wang; Kenny K Wong; Kithsiri B Herath; Brian K Hubbard; James Hubert; Douglas G Johns; Michael E Lassman; Wenyu Li; Theresa McLaughlin; Vivienne Mendoza; Stephen Previs; Thomas P Roddy
Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water.
Journal of lipid research 2012;53(6):1223-31.
2012: Kithsiri B Herath; Hiranthi Jayasuriya; John Phillips; Jon D Polishook; Jan Sigmund; Angela Basilio; Gerald F Bills; Mercedes de la Cruz; Robert Donald; Michael Goetz; FRANCISCA VCICENTE; Deborah L Zink; Sheo B Singh
Isolation, structure elucidation, and antibacterial activity of methiosetin, a tetramic acid from a tropical sooty mold (Capnodium sp.).
Journal of natural products 2012;75(3):420-4.
2011: Jose Castro-Perez; Zhu Chen; Athula Attygalle; Kithsiri B Herath; Brian K Hubbard; Douglas G Johns; David G McLaren; Lyndon J Mitnaul; Nico M M Nibbering; Stephen Previs; Thomas P Roddy; Vinit Shah; Rob Vreeken; Sheng-Ping Wang; Thomas Hankemeier
Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry.
Journal of the American Society for Mass Spectrometry 2011;22(9):1552-67.
2011: Kithsiri B Herath; Brian K Hubbard; Douglas G Johns; Christopher Johnson; Alison Kulick; Michael E Lassman; Paul L Miller; Stephen F Previs; Genevieve Andrews-Kelly; Gowi Bhat; Rory J Rohm; Sheng-Ping Wang; Thomas P Roddy
Equilibration of (2)H labeling between body water and free amino acids: enabling studies of proteome synthesis.
Analytical biochemistry 2011;415(2):197-9.
2011: Stephen F Previs; Sheng-Ping Wang; Jing Xu; Genevieve Andrews-Kelly; Karim Azer; Gowri Bhat; Keiana Dunn; Kithsiri B Herath; Brian K Hubbard; Douglas G Johns; Christopher Johnson; Alison Kulick; Ablatt Mahsut; Paul L Miller; Thomas P Roddy
Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject.
Journal of lipid research 2011;52(7):1420-8.
2011: Chaowei Zhang; John G Ondeyka; Kithsiri B Herath; Hiranthi Jayasuriya; Ziqiang Guan; Deborah L Zink; Lisa Dietrich; Bruce Burgess; Sookhee N Ha; Jun Wang; Sheo B Singh
Platensimycin and platencin congeners from Streptomyces platensis.
Journal of natural products 2011;74(3):329-40.
2011: Ablatt Mahsut; Sheng-Ping Wang; David G McLaren; Gowri Bhat; Kithsiri B Herath; Paul L Miller; Brian K Hubbard; Douglas G Johns; Stephen F Previs; Thomas P Roddy
Headspace analyses of ²H labeling of acetone: enabling studies of fatty acid oxidation in vivo.
Analytical biochemistry 2011;408(2):351-3.
2009: Sheo B Singh; John G Ondeyka; Kithsiri B Herath; Chaowei Zhang; Hiranthi Jayasuriya; Deborah L Zink; Gopalakrishnan Parthasarathy; Joseph W Becker; Jun Wang; Stephen M Soisson
Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorganic & medicinal chemistry letters 2009;19(16):4756-9.
2009: Chaowei Zhang; Kithsiri B Herath; Hiranthi Jayasuriya; John G Ondeyka; Deborah L Zink; James Occi; Gwyneth Birdsall; Jayashree Venugopal; Misti Ushio; Bruce Burgess; Prakash Masurekar; John F Barrett; Sheo B Singh
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
Journal of natural products 2009;72(5):841-7.
2008: Kithsiri B Herath; Chaowei Zhang; Hiranthi Jayasuriya; John G Ondeyka; Deborah L Zink; Bruce Burgess; Jun Wang; Sheo B Singh
Structure and semisynthesis of platensimide A, produced by Streptomyces platensis.
Organic letters 2008;10(9):1699-702.
2007: Kithsiri B Herath; Athula Attygalle; Sheo B Singh
Biosynthetic studies of platensimycin.
Journal of the American Chemical Society 2007;129(50):15422-3.
2007: Sheo B Singh; James Occi; Hiranthi Jayasuriya; Kithsiri B Herath; Mary Motyl; Karen Dorso; Charles Gill; Emily Hickey; Karen M Overbye; John F Barrett; Prakash Masurekar
Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
The Journal of antibiotics 2007;60(9):565-71.
2007: Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Chaowei Zhang; Deborah L Zink; Mark Brower; Francis P Gailliot; Joyce Greene; Gwyneth Birdsall; Jayashree Venugopal; Misti Ushio; Bruce Burgess; Greg Russotti; Andre Walker; Michelle Hesse; Anna Seeley; Beth Junker; Neal Connors; Oscar Salazar; Olga Genilloud; Kun Liu; Prakash Masurekar; John F Barrett; Sheo B Singh
Isolation and structure elucidation of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
The Journal of antibiotics 2007;60(9):554-64.
2007: Jun Wang; Srinivas Kodali; Sang Ho Lee; Andrew Galgoci; Ronald Painter; Karen Dorso; Fred Racine; Mary Motyl; Lorraine Hernandez; Elizabeth Tinney; Steven L Colletti; Kithsiri B Herath; Richard Cummings; Oscar Salazar; Ignacio González; Angela Basilio; FRANCISCA VCICENTE; Olga Genilloud; Fernando Pelaez; Hiranthi Jayasuriya; Katherine Young; Doris F Cully; Sheo B Singh
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7612-6.
2007: Hiranthi Jayasuriya; Kithsiri B Herath; Chaowei Zhang; Deborah L Zink; Angela Basilio; Olga Genilloud; Maria Teresa Diez; FRANCISCA VCICENTE; Ignacio Gonzalez; Oscar Salazar; Fernando Pelaez; Richard Cummings; Sookhee Ha; Jun Wang; Sheo B Singh
Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.
Angewandte Chemie (International ed. in English) 2007;46(25):4684-8.
2006: Sheo B Singh; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri B Herath; Chaowei Zhang; Deborah L Zink; Nancy N Tsou; Richard G Ball; Angela Basilio; Olga Genilloud; Maria Teresa Diez; FRANCISCA VCICENTE; Fernando Pelaez; Katherine Young; Jun Wang
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
Journal of the American Chemical Society 2006;128(36):11916-20.
2006: Chaowei Zhang; John G Ondeyka; Kithsiri B Herath; Ziqiang Guan; Javier Collado; Fernando Pelaez; Penny Sue Leavitt; Anne Gurnett; Bakela Nare; Paul A Liberator; Sheo B Singh
Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.
Journal of natural products 2006;69(4):710-2.
2006: Katherine Young; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri B Herath; Chaowei Zhang; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Vickie Brown-Driver; Robert Yamamoto; Lynn Silver; Yingcong Zheng; Judith I Ventura; Janet Sigmund; Sookhee Ha; Angela Basilio; FRANCISCA VCICENTE; José Rubén Tormo; Fernando Pelaez; Phil Youngman; Doris F Cully; John F Barrett; Dennis M Schmatz; Sheo B Singh; Jun Wang
Discovery of FabH/FabF inhibitors from natural products.
Antimicrobial agents and chemotherapy 2006;50(2):519-26.
2005: Kithsiri B Herath; Hiranthi Jayasuriya; John G Ondeyka; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Angeles Cabello; Pasquale P Vicario; Hans Zweerink; Ziqiang Guan; Sheo B Singh
Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists.
The Journal of antibiotics 2005;58(11):686-94.
2005: John G Ondeyka; Hiranthi Jayasuriya; Kithsiri B Herath; Ziqiang Guan; Marvin Schulman; Javier Collado; Anne W Dombrowski; Soojin S Kwon; Christine McCallum; Neelam Sharma; Karen L Macnaul; Nancy Hayes; John G Menke; Sheo B Singh
Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors.
The Journal of antibiotics 2005;58(9):559-65.
2005: Kithsiri B Herath; Hiranthi Jayasuriya; Ziqiang Guan; Marvin Schulman; Carolyn Ruby; Neelam Sharma; Karen L Macnaul; John G Menke; Srinivas Kodali; Andrew Galgoci; Jun Wang; Sheo B Singh
Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.
Journal of natural products 2005;68(9):1437-40.
2005: Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Ziqiang Guan; Robert P Borris; Suroojnauth Tiwari; Wil de Jong; Flor Chavez; Jeremy Moss; Dennis W Stevenson; Hans T Beck; Marc Slattery; Nelson Zamora; Marvin Schulman; Aisha Ali; Neelam Sharma; Karen L Macnaul; Nancy Hayes; John G Menke; Sheo B Singh
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
Journal of natural products 2005;68(8):1247-52.
2005: Kithsiri B Herath; Hiranthi Jayasuriya; John G Ondeyka; Ziqiang Guan; Robert P Borris; Eirik Stijfhoorn; Dennis Stevenson; Jianhua Wang; Neelam Sharma; Karen L Macnaul; John G Menke; Aisha Ali; Marvin Schulman; Sheo B Singh
Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.
Journal of natural products 2005;68(4):617-9.
2005: Chaowei Zhang; John G Ondeyka; Kithsiri B Herath; Ziqiang Guan; Javier Collado; Gonzalo Platas; Fernando Pelaez; Penny Sue Leavitt; Anne Gurnett; Bakela Nare; Paul A Liberator; Sheo B Singh
Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
Journal of natural products 2005;68(4):611-3.
2005: Srinivas Kodali; Andrew Galgoci; Katherine Young; Ronald Painter; Lynn Silver; Kithsiri B Herath; Sheo B Singh; Doris F Cully; John F Barrett; Dennis M Schmatz; Jun Wang
Determination of selectivity and efficacy of fatty acid synthesis inhibitors.
The Journal of biological chemistry 2005;280(2):1669-77.
2005: John G Ondeykal; Kithsiri B Herath; Hiranthi Jayasuriya; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Marina Mojena; Gregory Koch; Jerry DiSalvo; Julie A DeMartino; Ziqiang Guan; Weerachai Nanakorn; Cori M Morenberg; Michael J Balick; Dennis W Stevenson; Marc Slattery; Robert P Borris; Sheo B Singh
Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Molecular diversity 2005;9(1-3):123-9.
2004: Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; Manuel Sanchez; Ziqiang Guan; Suroojnauth Tiwari; Dennis W Stevenson; Robert P Borris; Sheo B Singh
Isolation and structure of antagonists of chemokine receptor (CCR5).
Journal of natural products 2004;67(6):1036-8.
2004: Kithsiri B Herath; Hiranthi Jayasuriya; Gerald F Bills; Jon D Polishook; Anne W Dombrowski; Ziqiang Guan; Peter J Felock; Daria J Hazuda; Sheo B Singh
Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide.
Journal of natural products 2004;67(5):872-4.
2004: Athula Attygalle; Xiaogang Wu; Josef Ruzicka; Sheetal Rao; Silvina Garcia; Kithsiri B Herath; Jerrold Meinwald; David R Maddison; Kipling W Will
Defensive chemicals of two species of Trachypachus Motschulski.
Journal of chemical ecology 2004;30(3):577-88.
2003: Jun Wang; Andrew Galgoci; Srinivas Kodali; Kithsiri B Herath; Hiranthi Jayasuriya; Karen Dorso; FRANCISCA VCICENTE; Antonio González; Doris F Cully; David Bramhill; Sheo Singh
Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics.
The Journal of biological chemistry 2003;278(45):44424-8.
2002: Sheo B Singh; Kithsiri B Herath; Ziqiang Guan; Deborah L Zink; Anne W Dombrowski; Jon D Polishook; Keith C Silverman; Russell Lingham; Peter J Felock; Daria J Hazuda
Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase.
Organic letters 2002;4(9):1431-4.
1998: Jerrold Meinwald; Q Huang; J Vrkoc; Kithsiri B Herath; Z C Yang; Frank Schroeder; Athula Attygalle; Vikram K Iyengar; R C Morgan; Thomas Eisner
Mirasorvone: a masked 20-ketopregnane from the defensive secretion of a diving beetle (Thermonectus marmoratus).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2733-7.
1997: Thomas Eisner; R C Morgan; Athula Attygalle; Scott R Smedley; Kithsiri B Herath; Jerrold Meinwald
Defensive production of quinoline by a phasmid insect (Oreophoetes peruana).
The Journal of experimental biology 1997;200(Pt 19):2493-500.