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Jonathan Ashwell

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Ivana Munitic; Jonathan P Scoville; Atef Allam; Mirela Kuka; Jonathan D Ashwell
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
Maria Letizia Giardino Torchia; Dragana Jankovic; Dietrich B Conze; Jonathan D Ashwell
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.
Mirela Kuka; Ivana Munitic; Jonathan D Ashwell
Identification and characterization of polyclonal αβ-T cells with dendritic cell properties.

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All Publications

2013: Ivana Munitic; Jonathan P Scoville; Atef Allam; Mirela Kuka; Jonathan D Ashwell
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1169-79.
2013: Maria Letizia Giardino Torchia; Dragana Jankovic; Dietrich B Conze; Jonathan D Ashwell
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):549-55.
2012: Mirela Kuka; Ivana Munitic; Jonathan D Ashwell
Identification and characterization of polyclonal αβ-T cells with dendritic cell properties.
Nature communications 2012;3():1223.
2011: Srinivasa M Srinivasula; Jonathan D Ashwell
A20: more than one way to skin a cat.
Molecular cell 2011;44(4):511-2.
2011: Ludmila Jirmanova; Paul R Mittelstadt; Nandakumara D Sarma; Maria Letizia Giardino Torchia; Jonathan D Ashwell
Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.
Blood 2011;118(12):3280-9.
2010: Ludmila Jirmanova; Jonathan D Ashwell
T cell priming: let there be light.
Cell research 2010;20(6):608-10.
2010: Dietrich B Conze; Yongge Zhao; Jonathan D Ashwell
Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.
PLoS biology 2010;8(10):e1000518.
2009: Atef Allam; Dietrich B Conze; Maria Letizia Giardino Torchia; Ivana Munitic; Hideo Yagita; Ryan T Sowell; Amanda L Marzo; Jonathan D Ashwell
The CD8+ memory T-cell state of readiness is actively maintained and reversible.
Blood 2009;114(10):2121-30.
2009: Yu-Chih Lo; Su-Chang Lin; Carla C Rospigliosi; Dietrich B Conze; Chuan-Jin Wu; Jonathan D Ashwell; David Eliezer; Hao Wu
Structural basis for recognition of diubiquitins by NEMO.
Molecular cell 2009;33(5):602-15.
2009: Ludmila Jirmanova; Dandapantula N Sarma; Dragana Jankovic; Paul R Mittelstadt; Jonathan D Ashwell
Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.
Blood 2009;113(10):2229-37.
2008: Jonathan D Ashwell
TWEAKing death.
The Journal of cell biology 2008;182(1):15-7.
2008: Dietrich B Conze; Chuan-Jin Wu; James A Thomas; Allison Landstrom; Jonathan D Ashwell
Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.
Molecular and cellular biology 2008;28(10):3538-47.
2008: Srinivasa M Srinivasula; Jonathan D Ashwell
IAPs: what's in a name?
Molecular cell 2008;30(2):123-35.
2008: Chuan-Jin Wu; Jonathan D Ashwell
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3023-8.
2007: Guozhi Zhu; Chuan-Jin Wu; Yongge Zhao; Jonathan D Ashwell
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.
Current biology : CB 2007;17(16):1438-43.
2007: Ludmila Jirmanova; Dragana Jankovic; Albert J Fornace; Jonathan D Ashwell
Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4153-8.
2007: Yongge Zhao; Dietrich B Conze; John Hanover; Jonathan D Ashwell
Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.
The Journal of biological chemistry 2007;282(11):7777-82.
2006: Jonathan D Ashwell
The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Nature reviews. Immunology 2006;6(7):532-40.
2006: Marco L Schito; Oleg N Demidov; Shin'ichi Saito; Jonathan D Ashwell; Ettore Appella
Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4818-25.
2006: Chuan-Jin Wu; Dietrich B Conze; Tao Li; Srinivasa M Srinivasula; Jonathan D Ashwell
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].
Nature cell biology 2006;8(4):398-406.
2005: Paul R Mittelstadt; Jesus M Salvador; Albert J Fornace; Jonathan D Ashwell
Activating p38 MAPK: new tricks for an old kinase.
Cell cycle (Georgetown, Tex.) 2005;4(9):1189-92.
2005: Chuan-Jin Wu; Dietrich B Conze; Xiaoming Li; Sai-Xia Ying; John Hanover; Jonathan D Ashwell
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.
The EMBO journal 2005;24(10):1886-98.
2005: Dietrich B Conze; Lori Albert; David A Ferrick; David V Goeddel; Wen-Chen Yeh; Tak Mak; Jonathan D Ashwell
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.
Molecular and cellular biology 2005;25(8):3348-56.
2005: Ivana Munitic; Philip E Ryan; Jonathan D Ashwell
T cells in G1 provide a memory-like response to secondary stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4010-8.
2005: Jesus M Salvador; Paul R Mittelstadt; Galina I Belova; Albert J Fornace; Jonathan D Ashwell
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Nature immunology 2005;6(4):396-402.
2005: Jesus M Salvador; Paul R Mittelstadt; Tad Guszczynski; Terry D Copeland; Hiroshi Yamaguchi; Ettore Appella; Albert J Fornace; Jonathan D Ashwell
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Nature immunology 2005;6(4):390-5.
2004: Ivana Munitic; Joy A Williams; Yili Yang; Bei Dong; Philip J Lucas; Nahed el-Kassar; Ronald E Gress; Jonathan D Ashwell
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.
Blood 2004;104(13):4165-72.
2004: Jonathan D Ashwell
Antigen-driven T cell expansion: affinity rules.
Immunity 2004;21(5):603-4.
2003: Paul R Mittelstadt; Jonathan D Ashwell
Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.
Molecular endocrinology (Baltimore, Md.) 2003;17(8):1534-42.
2002: Ugo D'Oro; Ivana Munitic; George Chacko; Tatiana S Karpova; James McNally; Jonathan D Ashwell
Regulation of constitutive TCR internalization by the zeta-chain.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6269-78.
2002: Yili Yang; Bei Dong; Paul R Mittelstadt; Hua Xiao; Jonathan D Ashwell
HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.
The Journal of biological chemistry 2002;277(22):19482-7.
2002: Jesus M Salvador; M Christine Hollander; Anh Thu Nguyen; Jeffrey B Kopp; Laura Barisoni; Jodene K Moore; Jonathan D Ashwell; Albert J Fornace
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
Immunity 2002;16(4):499-508.
2002: Xiaoming Li; Yili Yang; Jonathan D Ashwell
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
Nature 2002;416(6878):345-7.
2002: Denis Franchimont; Jérôme Galon; Melanie S Vacchio; Samuel Fan; Roberta Visconti; David M Frucht; Vincent Geenen; George Chrousos; Jonathan D Ashwell; John O'Shea
Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2212-8.
2002: Paul R Mittelstadt; Jérôme Galon; Denis Franchimont; John O'Shea; Jonathan D Ashwell
Glucocorticoid-inducible genes that regulate T-cell function.
Ernst Schering Research Foundation workshop 2002;(40):319-39.
2001: Paul R Mittelstadt; Jonathan D Ashwell
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.
The Journal of biological chemistry 2001;276(31):29603-10.
2001: Y Yang; Jonathan D Ashwell
Exploiting the apoptotic process for management of HIV: are we there yet?
Apoptosis : an international journal on programmed cell death 2001;6(1-2):139-46.
2000: Jonathan D Ashwell; Melanie S Vacchio; Jérôme Galon
Do glucocorticoids participate in thymocyte development?
Immunology today 2000;21(12):644-6.
2000: Melanie S Vacchio; Jonathan D Ashwell
Glucocorticoids and thymocyte development.
Seminars in immunology 2000;12(5):475-85.
2000: Yili Yang; Shengyun Fang; Jane P Jensen; Allan M Weissman; Jonathan D Ashwell
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
Science (New York, N.Y.) 2000;288(5467):874-7.
2000: Jyothi RENGARAJAN; Paul R Mittelstadt; Hans W Mages; Andrea J Gerth; Richard A Kroczek; Jonathan D Ashwell; Laurie H Glimcher
Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
Immunity 2000;12(3):293-300.
2000: F W Lu; K Yasutomo; G B Goodman; Louise J McHeyzer-Williams; Michael G McHeyzer-Williams; Ronald N Germain; Jonathan D Ashwell
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire.
Immunity 2000;12(2):183-92.
2000: Jonathan D Ashwell; F W Lu; Melanie S Vacchio
Glucocorticoids in T cell development and function*.
Annual review of immunology 2000;18():309-45.
1999: Yili Yang; Jonathan D Ashwell
Thymocyte apoptosis.
Journal of clinical immunology 1999;19(6):337-49.
1999: M Christine Hollander; MS Sheikh; Dmitry V Bulavin; K Lundgren; L Augeri-Henmueller; R Shehee; T A Molinaro; K E Kim; E Tolosa; Jonathan D Ashwell; Michael P Rosenberg; Qimin Zhan; P M Fernández-Salguero; William F Morgan; Chu-Xia Deng; Albert J Fornace
Genomic instability in Gadd45a-deficient mice.
Nature genetics 1999;23(2):176-84.
1999: Jonathan D Ashwell; Ugo D'Oro
CD45 and Src-family kinases: and now for something completely different.
Immunology today 1999;20(9):412-6.
1999: Y Yang; J S Hong; AM Eder; Jonathan D Ashwell
Bacterial death induced by expression of the intracellular portion of human Fas.
Cell death and differentiation 1999;6(8):805-12.
1999: LB King; E Tolosa; Joi M Lenczowski; F Lu; EF Lind; R Hunziker; Howard T Petrie; Jonathan D Ashwell
A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes.
International immunology 1999;11(8):1203-16.
1999: Melanie S Vacchio; J Y Lee; Jonathan D Ashwell
Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1327-33.
1999: Ugo D'Oro; Jonathan D Ashwell
Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1879-83.
1999: Paul R Mittelstadt; Jonathan D Ashwell
Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.
The Journal of biological chemistry 1999;274(5):3222-7.
1999: E Tolosa; Jonathan D Ashwell
Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development.
Neuroimmunomodulation 1999;6(1-2):90-6.
1998: AM Eder; L Dominguez; T F Franke; Jonathan D Ashwell
Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells.
The Journal of biological chemistry 1998;273(43):28025-31.
1998: Paul R Mittelstadt; Jonathan D Ashwell
Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression.
Molecular and cellular biology 1998;18(7):3744-51.
1998: Melanie S Vacchio; Jonathan D Ashwell; LB King
A positive role for thymus-derived steroids in formation of the T-cell repertoire.
Annals of the New York Academy of Sciences 1998;840():317-27.
1998: E Tolosa; LB King; Jonathan D Ashwell
Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice.
Immunity 1998;8(1):67-76.
1997: Ugo D'Oro; Melanie S Vacchio; Allan M Weissman; Jonathan D Ashwell
Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.
Immunity 1997;7(5):619-28.
1997: Melanie S Vacchio; Jonathan D Ashwell
Thymus-derived glucocorticoids regulate antigen-specific positive selection.
The Journal of experimental medicine 1997;185(11):2033-8.
1997: Yili Yang; Z H Liu; Carl Ware; Jonathan D Ashwell
A cysteine protease inhibitor prevents activation-induced T-cell apoptosis and death of peripheral blood cells from human immunodeficiency virus-infected individuals by inhibiting upregulation of Fas ligand.
Blood 1997;89(2):550-7.
1997: Joi M Lenczowski; L Dominguez; AM Eder; LB King; C M Zacharchuk; Jonathan D Ashwell
Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis.
Molecular and cellular biology 1997;17(1):170-81.
1996: Jonathan D Ashwell; LB King; Melanie S Vacchio
Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development.
Stem cells (Dayton, Ohio) 1996;14(5):490-500.
1996: Ugo D'Oro; Kazuyasu Sakaguchi; Ettore Appella; Jonathan D Ashwell
Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.
Molecular and cellular biology 1996;16(9):4996-5003.
1996: N N Khodarev; Jonathan D Ashwell
An inducible lymphocyte nuclear Ca2+/Mg(2+)-dependent endonuclease associated with apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):922-31.
1995: LB King; Melanie S Vacchio; K Dixon; R Hunziker; David Margulies; Jonathan D Ashwell
A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development.
Immunity 1995;3(5):647-56.
1995: Y Yang; Saverio Minucci; Keiko Ozato; R A Heyman; Jonathan D Ashwell
Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors.
The Journal of biological chemistry 1995;270(31):18672-7.
1995: Y Yang; M Merćep; Carl Ware; Jonathan D Ashwell
Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.
The Journal of experimental medicine 1995;181(5):1673-82.
1995: Y Yang; J Bailey; Melanie S Vacchio; Robert Yarchoan; Jonathan D Ashwell
Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3051-5.
1994: LB King; Melanie S Vacchio; Jonathan D Ashwell
To be or not to be: mutually antagonistic death signals regulate thymocyte apoptosis.
International archives of allergy and immunology 1994;105(4):355-8.
1994: B B Niklinska; D Hou; Carl H June; Allan M Weissman; Jonathan D Ashwell
CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.
Molecular and cellular biology 1994;14(12):8078-84.
1994: Y Yang; Saverio Minucci; D J Zand; Keiko Ozato; Jonathan D Ashwell
T cell activation and increases in protein kinase C activity enhance retinoic acid-induced gene transcription.
Molecular endocrinology (Baltimore, Md.) 1994;8(10):1370-6.
1994: D Petrak; S A Memon; Michael J Birrer; Jonathan D Ashwell; C M Zacharchuk
Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2046-51.
1994: Melanie S Vacchio; V Papadopoulos; Jonathan D Ashwell
Steroid production in the thymus: implications for thymocyte selection.
The Journal of experimental medicine 1994;179(6):1835-46.
1994: C M Burns; Kazuyasu Sakaguchi; Ettore Appella; Jonathan D Ashwell
CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.
The Journal of biological chemistry 1994;269(18):13594-600.
1994: C R Gattass; LB King; A D Luster; Jonathan D Ashwell
Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes.
The Journal of experimental medicine 1994;179(4):1373-8.
1994: Jonathan D Ashwell; N A Berger; J A Cidlowski; D P Lane; S J Korsmeyer
Coming to terms with death: apoptosis in cancer and immune development.
Immunology today 1994;15(4):147-51.
1994: LB King; Jonathan D Ashwell
Thymocyte and T cell apoptosis: is all death created equal?
Thymus 1994;23(3-4):209-30.
1994: Melanie S Vacchio; Jonathan D Ashwell
T cell tolerance.
Chemical immunology 1994;58():1-33.
1993: Y Yang; Melanie S Vacchio; Jonathan D Ashwell
9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6170-4.
1993: LB King; Jonathan D Ashwell
Signaling for death of lymphoid cells.
Current opinion in immunology 1993;5(3):368-73.
1993: S Volarević; B B Niklinska; C M Burns; Carl H June; Allan M Weissman; Jonathan D Ashwell
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains.
Science (New York, N.Y.) 1993;260(5107):541-4.
1993: S Wu; Y Yang; Scheherazade Sadegh-Nasseri; Jonathan D Ashwell
Use of bispecific heteroconjugated antibodies (anti-T cell antigen receptor x anti-MHC class II) to study activation of T cells with a full length or truncated antigen receptor zeta-chain.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2211-21.
1993: C M Burns; Jonathan D Ashwell
T-cell activation: ZAPping the T-cell receptor.
Current biology : CB 1993;3(2):97-9.
1992: E K Codias; T J Fleming; C M Zacharchuk; Jonathan D Ashwell; Thomas R Malek
Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):1825-52.
1992: S Volarević; B B Niklinska; C M Burns; H Yamada; Carl H June; F J Dumont; Jonathan D Ashwell
The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.
The Journal of experimental medicine 1992;176(3):835-44.
1992: Stuart J Frank; C Cenciarelli; B B Niklinska; F Letourneur; Jonathan D Ashwell; Allan M Weissman
Mutagenesis of T cell antigen receptor zeta chain tyrosine residues. Effects on tyrosine phosphorylation and lymphokine production.
The Journal of biological chemistry 1992;267(19):13656-60.
1992: C M Zacharchuk; Jonathan D Ashwell
Fruitful outcomes of intracellular cross-talk.
Current biology : CB 1992;2(5):246-8.
1992: B B Niklinska; H Yamada; John O'Shea; Carl H June; Jonathan D Ashwell
Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells.
The Journal of biological chemistry 1992;267(10):7154-9.
1991: C M Zacharchuk; M Merćep; Jonathan D Ashwell
Thymocyte activation and death: a mechanism for molding the T cell repertoire.
Annals of the New York Academy of Sciences 1991;636():52-70.
1991: C M Zacharchuk; M Merćep; Carl H June; Allan M Weissman; Jonathan D Ashwell
Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):460-5.
1991: Jonathan D Ashwell
Pas de deux.
Current biology : CB 1991;1(2):111-3.
1990: C M Zacharchuk; M Merćep; P K Chakraborti; S Stoney Simons; Jonathan D Ashwell
Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4037-45.
1990: S Volarević; C M Burns; J J Sussman; Jonathan D Ashwell
Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7085-9.
1990: Stuart J Frank; B B Niklinska; D G Orloff; M Merćep; Jonathan D Ashwell; Richard D Klausner
Structural mutations of the T cell receptor zeta chain and its role in T cell activation.
Science (New York, N.Y.) 1990;249(4965):174-7.
1989: Allan M Weissman; Stuart J Frank; D G Orloff; M Merćep; Jonathan D Ashwell; Richard D Klausner
Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.
The EMBO journal 1989;8(12):3651-6.
1989: M Merćep; Allan M Weissman; Stuart J Frank; Richard D Klausner; Jonathan D Ashwell
Activation-driven programmed cell death and T cell receptor zeta eta expression.
Science (New York, N.Y.) 1989;246(4934):1162-5.
1989: M Merćep; P D Noguchi; Jonathan D Ashwell
The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):4085-92.
1988: M Merćep; Juan Bonifacino; P Garcia-Morales; Lawrence E Samelson; Richard D Klausner; Jonathan D Ashwell
T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.
Science (New York, N.Y.) 1988;242(4878):571-4.
1988: Jonathan D Ashwell; Marc K Jenkins; R H Schwartz
Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2536-44.
1988: Juan Bonifacino; C Chen; Jennifer Lippincott-Schwartz; Jonathan D Ashwell; Richard D Klausner
Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6929-33.
1988: J J Sussman; M Merćep; T Saito; R N Germain; E Bonvini; Jonathan D Ashwell
Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma.
Nature 1988;334(6183):625-8.
1988: Jonathan D Ashwell
Are B lymphocytes the principal antigen-presenting cells in vivo?
Journal of immunology (Baltimore, Md. : 1950) 1988;140(11):3697-700.
1988: J J Sussman; T Saito; Ethan M Shevach; R N Germain; Jonathan D Ashwell
Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2520-6.
1988: J J Sussman; Juan Bonifacino; Jennifer Lippincott-Schwartz; Allan M Weissman; T Saito; Richard D Klausner; Jonathan D Ashwell
Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex.
Cell 1988;52(1):85-95.
1988: Juan Bonifacino; M Merćep; J J Sussman; Richard D Klausner; Jonathan D Ashwell
The T-cell antigen receptor: a complex signal-transducing molecule.
Princess Takamatsu symposia 1988;19():87-104.
1988: M Merćep; J A Bluestone; P D Noguchi; Jonathan D Ashwell
Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(1):324-35.