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Piet Herdewijn

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Publications

TOP 3
Carine Baraguey; Françoise Debart; Piet Herdewijn; Thomas Lavergne; Eveline Lescrinier; Jean-Jacques Vasseur
The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.
Mi-Yeon Jang; Eveline Lescrinier; Philippe Marlière; Jef Rozenski; Xiao-Ping Song; Matheus Froeyen; Piet Herdewijn
A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates.
Alessandro Stella; Kristien Van Belle; Mark Waer; Steven De Jonghe; Jean Herman; Thierry Louat; Jef Rozenski; Piet Herdewijn
Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay.

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2013: Carine Baraguey; Françoise Debart; Piet Herdewijn; Thomas Lavergne; Eveline Lescrinier; Jean-Jacques Vasseur
The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.
Organic & biomolecular chemistry 2013;11(16):2638-47.
2013: Mi-Yeon Jang; Eveline Lescrinier; Philippe Marlière; Jef Rozenski; Xiao-Ping Song; Matheus Froeyen; Piet Herdewijn
A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates.
Chemistry & biology 2013;20(3):416-23.
2013: Alessandro Stella; Kristien Van Belle; Mark Waer; Steven De Jonghe; Jean Herman; Thierry Louat; Jef Rozenski; Piet Herdewijn
Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay.
Bioorganic & medicinal chemistry 2013;21(5):1209-18.
2013: Amritraj Patra; Linlin Zhao; Mikhail Abramov; Joel Harp; Piet Herdewijn; Pradeep S Pallan; Martin Egli
Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic acids research 2013;41(4):2689-97.
2013: Joleen Masschelein; Wesley Mattheus; Chris Michiels; Pieter Moons; Jef Rozenski; Birgit Uytterhoeven; Rob Van Houdt; Abram Aertsen; Ling-Jie Gao; Piet Herdewijn; Chris Lamberigts; Eveline Lescrinier; Rob Lavigne
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics.
PloS one 2013;8(1):e54143.
2013: Ling-Jie Gao; J Stephan Schwed; Holger Stark; Lilia Weizel; Steven De Jonghe; Piet Herdewijn
Synthesis and evaluation of novel ligands for the histamine H₄ receptor based on a pyrrolo[2,3-d]pyrimidine scaffold.
Bioorganic & medicinal chemistry letters 2013;23(1):132-7.
2012: Xiao-Ping Song; Eveline Lescrinier; Camille Bouillon; Piet Herdewijn
Dipeptides as leaving group in the enzyme-catalyzed DNA synthesis.
Chemistry & biodiversity 2012;9(12):2685-700.
2012: Anne Giraut; Rania Abu El-Asrar; Marc Delarue; Philippe Marlière; Piet Herdewijn
2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.
Chembiochem : a European journal of chemical biology 2012;13(16):2439-44.
2012: Shiqiong Yang; Christophe Pannecouque; Piet Herdewijn
Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators.
Chemistry & biodiversity 2012;9(10):2186-94.
2012: Marijke Stevens; Natalia Dyubankova; Piet Herdewijn; Eveline Lescrinier; Steve Peigneur; Jan Tytgat
Design of bioactive peptides from naturally occurring μ-conotoxin structures.
The Journal of biological chemistry 2012;287(37):31382-92.
2012: Shrinivas Dumbre; Adeline Derouaux; Bernard Joris; Eveline Lescrinier; André Piette; Mohammed Terrak; Piet Herdewijn
Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.
Journal of the American Chemical Society 2012;134(22):9343-51.
2012: Punit P Seth; Jinghua Yu; Michael E Østergaard; Charles R Allerson; Martin Egli; Piet Herdewijn; Ali Jazayeri; Fengwu Liu; Pradeep S Pallan; Eric E Swayze
Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.
The Journal of organic chemistry 2012;77(11):5074-85.
2012: Vitor B Pinheiro; Marleen Renders; Alexander I Taylor; Jesper Wengel; Su Zhang; Mikhail Abramov; John C Chaput; Christopher Cozens; Piet Herdewijn; Stephen H McLaughlin; Sew-Yeu Peak Chew; Philipp Holliger
Synthetic genetic polymers capable of heredity and evolution.
Science (New York, N.Y.) 2012;336(6079):341-4.
2012: Martin Kögler; Thierry Louat; Hélène Munier-Lehmann; Jef Rozenski; Kristien Van Belle; Roger Busson; Steven De Jonghe; Piet Herdewijn
Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Chemistry & biodiversity 2012;9(3):536-56.
2012: Annelies Van Der Haegen; Elia Diego-García; Natalia Dyubankova; Piet Herdewijn; Eveline Lescrinier; Frank Marí; Carolina Möller; Ryno Naudé; Steve Peigneur; Jan Tytgat
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity.
Peptides 2012;34(1):106-13.
2012: Mohitosh Maiti; Koen Nauwelaerts; Piet Herdewijn
Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.
Bioorganic & medicinal chemistry letters 2012;22(4):1709-11.
2012: Shiqiong Yang; Anne Giraut; Eveline Lescrinier; Christophe Pannecouque; Piet Herdewijn
Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.
Organic & biomolecular chemistry 2012;10(1):146-53.
2011: Xiao-Ping Song; Eveline Lescrinier; Camille Bouillon; Piet Herdewijn
Iminodipropionic acid as the leaving group for DNA polymerization by HIV-1 reverse transcriptase.
Chembiochem : a European journal of chemical biology 2011;12(12):1868-80.
2011: Servaas Michielssens; Samuel L C Moors; Matheus Froeyen; Piet Herdewijn; Arnout Ceulemans
Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase.
Biophysical chemistry 2011;157(1-3):1-6.
2011: Philippe Marlière; Julien Patrouix; Sabine Tricot; M Bouzon; Stéphane Cruveiller; Volker Döring; Piet Herdewijn; Rupert Mutzel
Chemical evolution of a bacterium's genome.
Angewandte Chemie (International ed. in English) 2011;50(31):7109-14.
2011: Martin Kögler; Eveline Lescrinier; Thierry Louat; Anastasia Parchina; Jef Rozenski; Carol Sibley; Kristien Van Belle; Bart Vanderhoydonck; Steven De Jonghe; Jean Herman; Piet Herdewijn
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
Journal of medicinal chemistry 2011;54(13):4847-62.
2011: Margriet Ovaere; Piet Herdewijn; Luc Van Meervelt
The crystal structure of the CeNA:RNA hybrid ce(GCGTAGCG):r(CGCUACGC).
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(28):7823-30.
2011: Shiqiong Yang; Piet Herdewijn
Polymerase-dependent DNA synthesis from phosphoramidate-activated nucleotides.
Nucleosides, nucleotides & nucleic acids 2011;30(7-8):597-608.
2011: Qiuya Huang; Piet Herdewijn
Synthesis of (E)-3'-phosphonoalkenyl modified nucleoside phosphonates via a highly stereoselective olefin cross-metathesis reaction.
The Journal of organic chemistry 2011;76(10):3742-53.
2011: Alessandro Stella; Kenneth Segers; Steven De Jonghe; Bart Vanderhoydonck; Jef Rozenski; Jozef Anne; Piet Herdewijn
Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles.
Chemistry & biodiversity 2011;8(2):253-65.
2011: Mohitosh Maiti; Koen Nauwelaerts; Eveline Lescrinier; Piet Herdewijn
Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(5):1519-28.
2011: Mi-Yeon Jang; Yuan Lin; Steven De Jonghe; Ling-Jie Gao; Bart Vanderhoydonck; Matheus Froeyen; Jef Rozenski; Jean Herman; Thierry Louat; Kristien Van Belle; Mark Waer; Piet Herdewijn
Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.
Journal of medicinal chemistry 2011;54(2):655-68.
2011: Jennifer Vandooren; Nathalie Geurts; Erik Martens; Philippe E Van den Steen; Steven De Jonghe; Piet Herdewijn; Ghislain Opdenakker
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.
World journal of biological chemistry 2011;2(1):14-24.
2011: Shiqiong Yang; Matheus Froeyen; Eveline Lescrinier; Philippe Marlière; Piet Herdewijn
3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.
Organic & biomolecular chemistry 2011;9(1):111-9.
2011: Steven De Jonghe; Arnaud Marchand; Ling-Jie Gao; Agnes Calleja; Eva Cuveliers; Ilse Sienaert; Jean Herman; Gavin Clydesdale; Hassane Sefrioui; Yuan Lin; Wolfgang Pfleiderer; Mark Waer; Piet Herdewijn
Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.
Bioorganic & medicinal chemistry letters 2011;21(1):145-9.
2011: Mi-Yeon Jang; Steven De Jonghe; Kenneth Segers; Jozef Anne; Piet Herdewijn
Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors.
Bioorganic & medicinal chemistry 2011;19(1):702-14.
2010: Mohammed T A Salim; Yukinori Goto; Takayuki Hamasaki; Mika Okamoto; Hiroshi Aoyama; Yuichi Hashimoto; Simone Musiu; Jan Paeshuyse; Johan Neyts; Matheus Froeyen; Piet Herdewijn; Masanori Baba
Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives.
Antiviral research 2010;88(3):263-8.
2010: Suzanne J F Kaptein; Tine De Burghgraeve; Matheus Froeyen; Boris Pastorino; Marijke M F Alen; Juan A Mondotte; Piet Herdewijn; Michael Jacobs; Xavier de Lamballerie; Dominique Schols; Andrea V Gamarnik; Ferenc Sztaricskai; Johan Neyts
A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro.
Antimicrobial agents and chemotherapy 2010;54(12):5269-80.
2010: Wesley Mattheus; Joleen Masschelein; Ling-Jie Gao; Piet Herdewijn; Bart Landuyt; Guido Volckaert; Rob Lavigne
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.
Chemistry & biology 2010;17(10):1067-71.
2010: Daniele D'Alonzo; annalisa guaragna; Arthur Van Aerschot; Piet Herdewijn; Giovanni Palumbo
Toward L-homo-DNA: stereoselective de novo synthesis of β-L-erythro-hexopyranosyl nucleosides.
The Journal of organic chemistry 2010;75(19):6402-10.
2010: Koen Robeyns; Piet Herdewijn; Luc Van Meervelt
Comparison between the orthorhombic and tetragonal forms of the heptamer sequence d[GCG(xT)GCG]/d(CGCACGC).
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 9):1028-31.
2010: Jesper B Bramsen; Malgorzata M Pakula; Thomas B Hansen; Claus Bus; Niels Langkjær; Dalibor Odadzic; Romualdas Smicius; Suzy L Wengel; Jyoti Chattopadhyaya; Joachim W Engels; Piet Herdewijn; Jesper Wengel; Jørgen Kjems
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Nucleic acids research 2010;38(17):5761-73.
2010: Eveline Lescrinier; Natalia Dyubankova; Koen Nauwelaerts; Roger Jones; Piet Herdewijn
Structure determination of the top-loop of the conserved 3'-terminal secondary structure in the genome of flaviviruses.
Chembiochem : a European journal of chemical biology 2010;11(10):1404-12.
2010: Anne Giraut; Piet Herdewijn
Influence of the linkage between leaving group and nucleoside on substrate efficiency for incorporation in DNA catalyzed by reverse transcriptase.
Chembiochem : a European journal of chemical biology 2010;11(10):1399-403.
2010: Anne Giraut; Xiao-ping Song; Matheus Froeyen; Philippe Marlière; Piet Herdewijn
Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid polymerization in vivo.
Nucleic acids research 2010;38(8):2541-50.
2010: Margriet Ovaere; Arthur Van Aerschot; Mikhail Abramov; Piet Herdewijn; Luc Van Meervelt
Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 4):460-2.
2010: Wesley Mattheus; Ling-Jie Gao; Piet Herdewijn; Bart Landuyt; Jan Verhaegen; Joleen Masschelein; Guido Volckaert; Rob Lavigne
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster.
Chemistry & biology 2010;17(2):149-59.
2010: Mohitosh Maiti; Koen Nauwelaerts; Eveline Lescrinier; Frans C Schuit; Piet Herdewijn
Self-complementary sequence context in mature miRNAs.
Biochemical and biophysical research communications 2010;392(4):572-6.
2010: Mi-Yeon Jang; Steven De Jonghe; Kristien Van Belle; Thierry Louat; Mark Waer; Piet Herdewijn
Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues.
Bioorganic & medicinal chemistry letters 2010;20(3):844-7.
2010: Amutha Ramaswamy; Mathy Froeyen; Piet Herdewijn; Arnout Ceulemans
Helical structure of xylose-DNA.
Journal of the American Chemical Society 2010;132(2):587-95.
2010: Piet Herdewijn
Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone.
Chemistry & biodiversity 2010;7(1):1-59.
2010: Tong Li; Matheus Froeyen; Piet Herdewijn
Insight into ligand selectivity in HCV NS5B polymerase: molecular dynamics simulations, free energy decomposition and docking.
Journal of molecular modeling 2010;16(1):49-59.
2009: Mikhail Abramov; Marleen Renders; Piet Herdewijn
Synthesis of 2'-N-formamido nucleosides and biological evaluation.
Nucleosides, nucleotides & nucleic acids 2009;28(11):1042-50.
2009: Tomoko Wakabayashi; Katleen Craessaerts; Leen Bammens; Mostafa Bentahir; Filip Borgions; Piet Herdewijn; An Staes; Evy Timmerman; Joël Vandekerckhove; Eric Rubinstein; Claude Boucheix; Kris Gevaert; Bart De Strooper
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.
Nature cell biology 2009;11(11):1340-6.
2009: Katrijn Bockstael; Nick Geukens; Lieve Van Mellaert; Piet Herdewijn; Jozef Anne; Arthur Van Aerschot
Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis.
Microbiology (Reading, England) 2009;155(Pt 11):3719-29.
2009: Daniele D'Alonzo; Arthur Van Aerschot; Annalisa Guaragna; Giovanni Palumbo; Guy Schepers; Stefania Capone; Jef Rozenski; Piet Herdewijn
Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(39):10121-31.
2009: Ivan Zlatev; Anne Giraut; François Morvan; Piet Herdewijn; Jean-Jacques Vasseur
Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry 2009;17(19):7008-14.
2009: Servaas Michielssens; Nguyen Tien Trung; Matheus Froeyen; Piet Herdewijn; Minh Tho Nguyen; Arnout Ceulemans
Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study.
Physical chemistry chemical physics : PCCP 2009;11(33):7274-85.
2009: Anne Giraut; Natalia Dyubankova; Xiao-ping Song; Piet Herdewijn
Phosphodiester substrates for incorporation of nucleotides in DNA using HIV-1 reverse transcriptase.
Chembiochem : a European journal of chemical biology 2009;10(13):2246-52.
2009: Sergey N Mikhailov; Edward N Timofeev; Mikhail S Drenichev; Ekaterina V Efimtseva; Piet Herdewijn; Eric B Roesch; Marc M Lemaitre
Oligodeoxynucleotides containing N1-methyl-2'-deoxyadenosine and N6-methyl-2'-deoxyadenosine.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2009;Chapter 4():Unit 4.36 1-19.
2009: Katrijn Bockstael; Nick Geukens; C V Smitha Rao; Piet Herdewijn; Jozef Anne; Arthur Van Aerschot
An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors.
Journal of microbiological methods 2009;78(2):231-7.
2009: Piet Herdewijn; Philippe Marlière
Toward safe genetically modified organisms through the chemical diversification of nucleic acids.
Chemistry & biodiversity 2009;6(6):791-808.
2009: Jan Paeshuyse; Carine Letellier; Matheus Froeyen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Erik De Clercq; Alain Gueiffier; Jean-Claude Teulade; Piet Herdewijn; Gerhard Puerstinger; Frank Koenen; Pierre Kerkhofs; Pier Giovanni Baraldi; Johan Neyts
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Antiviral research 2009;82(3):141-7.
2009: Peter Buzder-Lantos; Katrijn Bockstael; Jozef Anne; Piet Herdewijn
Substrate based peptide aldehyde inhibits bacterial type I signal peptidase.
Bioorganic & medicinal chemistry letters 2009;19(10):2880-3.
2009: Guojie Wang; Georgii V Bobkov; Sergey N Mikhailov; Guy Schepers; Arthur Van Aerschot; Jef Rozenski; Mark Van Der Auweraer; Piet Herdewijn; Steven De Feyter
Detection of RNA hybridization by pyrene-labeled probes.
Chembiochem : a European journal of chemical biology 2009;10(7):1175-85.
2009: Qiuya Huang; Piet Herdewijn
Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety.
Nucleosides, nucleotides & nucleic acids 2009;28(5):337-51.
2009: Michael Fisher; Mikhail Abramov; Arthur Van Aerschot; Jef Rozenski; Vidula Dixit; Rudy L Juliano; Piet Herdewijn
Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf.
European journal of pharmacology 2009;606(1-3):38-44.
2009: Stijn Deborggraeve; Ximena Coronado; Aldo Solari; Ines Zulantay; Werner Apt; Pascal Mertens; Thierry Laurent; Thierry Leclipteux; Tim Stessens; Jean-Claude Dujardin; Piet Herdewijn; Philippe Büscher
T. cruzi OligoC-TesT: a simplified and standardized polymerase chain reaction format for diagnosis of Chagas disease.
PLoS neglected tropical diseases 2009;3(6):e450.
2009: Marleen Renders; Mikhail Abramov; Matheus Froeyen; Piet Herdewijn
Polymerase-catalysed incorporation of glucose nucleotides into a DNA duplex.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(22):5463-70.
2008: Marleen Renders; Roel Lievrouw; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic polymerization of phosphonate nucleosides.
Chembiochem : a European journal of chemical biology 2008;9(17):2883-8.
2008: Stijn Deborggraeve; Thierry Laurent; Diego Espinosa; Gert Van der Auwera; Margaret Mbuchi; Monique Wasunna; Sayda El-Safi; Ahmed Almustafa Al-Basheer; Jorge Arévalo; César Miranda-Verástegui; Thierry Leclipteux; Pascal Mertens; Jean-Claude Dujardin; Piet Herdewijn; Philippe Büscher
A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis.
The Journal of infectious diseases 2008;198(10):1565-72.
2008: Stijn Deborggraeve; Marleen Boelaert; Suman Rijal; Simonne De Doncker; Jean-Claude Dujardin; Piet Herdewijn; Philippe Büscher
Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease.
Tropical medicine & international health : TM & IH 2008;13(11):1378-83.
2008: Tong Li; Matheus Froeyen; Piet Herdewijn
Comparative structural dynamics of Tyrosyl-tRNA synthetase complexed with different substrates explored by molecular dynamics.
European biophysics journal : EBJ 2008;38(1):25-35.
2008: Guojie Wang; Mikhail Abramov; Arthur Van Aerschot; Jef Rozenski; Shengbin Lei; Andrey S Klymchenko; Mark Van Der Auweraer; Steven De Feyter; Piet Herdewijn
Dendritic nucleotides: interaction with an aliphatic acid monolayer.
Chemistry & biodiversity 2008;5(9):1675-82.
2008: Jan Paeshuyse; Inge Vliegen; Lotte Coelmont; Pieter Leyssen; Oriana Tabarrini; Piet Herdewijn; Harald Mittendorfer; Johnny Easmon; Violetta Cecchetti; Ralf Bartenschlager; Gerhard Puerstinger; Johan Neyts
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Antimicrobial agents and chemotherapy 2008;52(9):3433-7.
2008: Stijn Deborggraeve; Mathurin Koffi; Vincent Jamonneau; Frank A Bonsu; Richard Queyson; Pere P Simarro; Piet Herdewijn; Philippe Büscher
Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection.
Diagnostic microbiology and infectious disease 2008;61(4):428-33.
2008: Mikhail Abramov; Guy Schepers; Arthur Van Aerschot; Paul van Hummelen; Piet Herdewijn
HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches.
Biosensors & bioelectronics 2008;23(11):1728-32.
2008: Feng-Wu Liu; Alberto Di Salvo; Piet Herdewijn
Synthesis of 2'-cyclohexenylnucleosides and corresponding CeNA building blocks.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2008;Chapter 1():Unit 1.20.
2008: Pieter Van de Vijver; Tomasz Ostrowski; Brian Sproat; Jozef Goebels; Omer Rutgeerts; Arthur Van Aerschot; Mark Waer; Piet Herdewijn
Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants.
Journal of medicinal chemistry 2008;51(10):3020-9.
2008: Koen Robeyns; Piet Herdewijn; Luc Van Meervelt
Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG).
Nucleic acids research 2008;36(5):1407-14.
2008: Koen Robeyns; Piet Herdewijn; Luc Van Meervelt
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC.
Journal of the American Chemical Society 2008;130(6):1979-84.
2008: Robert Vrancken; Jan Paeshuyse; A Haegeman; Gerhard Puerstinger; Matheus Froeyen; Piet Herdewijn; Pierre Kerkhofs; Johan Neyts; Frank Koenen
Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.
Antiviral research 2008;77(2):114-9.
2008: Montserrat Terrazas; Philippe Marlière; Piet Herdewijn
Enzymatically catalyzed DNA synthesis using L-Asp-dGMP, L-Asp-dCMP, and L-Asp-dTMP.
Chemistry & biodiversity 2008;5(1):31-9.
2008: Tong Li; Matheus Froeyen; Piet Herdewijn
Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex.
Journal of molecular graphics & modelling 2008;26(5):813-23.
2007: Felix Voigts-Hoffmann; Martin Hengesbach; Andrei Yu Kobitski; Arthur Van Aerschot; Piet Herdewijn; G Ulrich Nienhaus; Mark Helm
A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys).
Journal of the American Chemical Society 2007;129(44):13382-3.
2007: Anca Margineanu; Steven De Feyter; Sergey Melnikov; Damien Marchand; Arthur Van Aerschot; Piet Herdewijn; Satoshi Habuchi; Frans C De Schryver; Johan Hofkens
Complexation of lipofectamine and cholesterol-modified DNA sequences studied by single-molecule fluorescence techniques.
Biomacromolecules 2007;8(11):3382-92.
2007: Jan Paeshuyse; Jean-Michel Chezal; Matheus Froeyen; Pieter Leyssen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Carine Letellier; Tong Li; Harald Mittendorfer; Frank Koenen; Pierre Kerkhofs; Erik De Clercq; Piet Herdewijn; Gerhard Puerstinger; Alain Gueiffier; Olivier Chavignon; Jean-Claude Teulade; Johan Neyts
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Journal of virology 2007;81(20):11046-53.
2007: Mikhail Abramov; Piet Herdewijn
Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2007;Chapter 1():Unit 1.18.
2007: Miguel Stevens; Jan Balzarini; Irene M Lagoja; Bernard Noppen; Katrien François; Arthur Van Aerschot; Piet Herdewijn; Erik De Clercq; Christophe Pannecouque
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.
Virology 2007;365(1):220-37.
2007: Koen Nauwelaerts; Michael Fisher; Matheus Froeyen; Eveline Lescrinier; Arthur Van Aerschot; Dong Xu; Robert DeLong; Hyumin Kang; Rudy L Juliano; Piet Herdewijn
Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides.
Journal of the American Chemical Society 2007;129(30):9340-8.
2007: Arnaud Marchand; Damien Marchand; Roger Busson; Philipe Marlière; Piet Herdewijn
Synthesis of a pyridoxine-peptide based delivery system for nucleotides.
Chemistry & biodiversity 2007;4(7):1450-65.
2007: Irene M Lagoja; Piet Herdewijn
Use of RNA in drug design.
Expert opinion on drug discovery 2007;2(6):889-903.
2007: Irene M Lagoja; Piet Herdewijn
Preparation of guanine and diaminopurine from biuret. Part III.
Chemistry & biodiversity 2007;4(4):818-22.
2007: Matheus Froeyen; François Morvan; Jean-Jacques Vasseur; Peter Nielsen; Arthur Van Aerschot; Helmut Rosemeyer; Piet Herdewijn
Conformational and chiral selection of oligonucleotides.
Chemistry & biodiversity 2007;4(4):803-17.
2007: Ding Zhou; Matheus Froeyen; Jef Rozenski; Arthur Van Aerschot; Piet Herdewijn
Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs).
Chemistry & biodiversity 2007;4(4):740-61.
2007: Piet Herdewijn; Rudy L Juliano
Nucleic acids with a six-membered carbohydrate mimic and RNA interference.
Blood cells, molecules & diseases 2007;38(2):100-1.
2007: Sergey N Mikhailov; Ekaterina V Efimtseva; Andrei A Rodionov; Georgii V Bobkov; Irina V Kulikova; Piet Herdewijn
Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2007;Chapter 1():Unit 1.14.
2007: Helmut Vorbrüggen; Irene M Lagoja; Piet Herdewijn
Synthesis of ribonucleosides by condensation using trimethylsilyl triflate.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2007;Chapter 1():Unit 1.13.
2007: Sergey N Mikhailov; Georgii V Bobkov; Kyrill V Brilliantov; Jef Rozenski; Arthur Van Aerschot; Piet Herdewijn; Michael H Fisher; Rudy L Juliano
2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1509-12.
2007: Helmut Rosemeyer; Eva-Maria Stürenberg; Piet Herdewijn
Nucleolipids as potential organogelators.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):995-9.
2007: O Adelfinskaya; M Terrazas; Matheus Froeyen; Philippe Marlière; Koen Nauwelaerts; Piet Herdewijn
Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids.
Nucleic acids research 2007;35(15):5060-72.
2007: Gert Emmerechts; Sofie Barbé; Piet Herdewijn; Jozef Anne; Jef Rozenski
Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays.
Nucleic acids research 2007;35(10):3494-503.
2007: Olga Adelfinskaya; Piet Herdewijn
Amino acid phosphoramidate nucleotides as alternative substrates for HIV-1 reverse transcriptase.
Angewandte Chemie (International ed. in English) 2007;46(23):4356-8.
2007: Marleen Renders; Gert Emmerechts; Jef Rozenski; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.
Angewandte Chemie (International ed. in English) 2007;46(14):2501-4.
2007: Michael Fisher; Mikhail Abramov; Arthur Van Aerschot; Dong Xu; Rudy L Juliano; Piet Herdewijn
Inhibition of MDR1 expression with altritol-modified siRNAs.
Nucleic acids research 2007;35(4):1064-74.
2007: Koen Nauwelaerts; Eveline Lescrinier; Piet Herdewijn
Structure of the alpha-homo-DNA:RNA duplex and the function of twist and slide to catalogue nucleic acid duplexes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(1):90-8.
2006: Mieke Vanhaecke; Wim Van den Ende; André Van Laere; Piet Herdewijn; Eveline Lescrinier
Complete NMR characterization of lychnose from Stellaria media (L.) Vill.
Carbohydrate research 2006;341(16):2744-50.
2006: Gerhard Puerstinger; Jan Paeshuyse; Piet Herdewijn; Jef Rozenski; Erik De Clercq; Johan Neyts
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5345-9.
2006: Piet Herdewijn
The interplay between antiviral activity, oligonucleotide hybridisation and nucleic acids incorporation studies.
Antiviral research 2006;71(2-3):317-21.
2006: Tongfei Wu; Koen Nauwelaerts; Arthur Van Aerschot; Matheus Froeyen; Eveline Lescrinier; Piet Herdewijn
Base-base interactions in the minor groove of double-stranded DNA.
The Journal of organic chemistry 2006;71(15):5423-31.
2006: Claudine Fraipont; Frédéric Sapunaric; Astrid Zervosen; Geneviève Auger; Bart Devreese; Thierry Lioux; Didier Blanot; Dominique Mengin-Lecreulx; Piet Herdewijn; Jozef Van Beeumen; Jean-Marie Frère; Martine Nguyen-Distèche
Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: specificity profile for the substrate.
Biochemistry 2006;45(12):4007-13.
2006: Eveline Lescrinier; Koen Nauwelaerts; Katia Zanier; Koen Poesen; Michael Sattler; Piet Herdewijn
The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif.
Nucleic acids research 2006;34(10):2878-86.
2006: Jan Paeshuyse; Pieter Leyssen; Eric Mabery; Nina Boddeker; Robert Vrancken; Matheus Froeyen; Israrul H Ansari; Hélène Dutartre; Jef Rozenski; Laura H V G Gil; Carine Letellier; Robert E Lanford; Bruno Canard; Frank Koenen; Pierre Kerkhofs; Ruben O Donis; Piet Herdewijn; Julia Watson; Erik De Clercq; Gerhard Puerstinger; Johan Neyts
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Journal of virology 2006;80(1):149-60.
2005: Ding Zhou; Irene M Lagoja; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Synthesis and properties of aminopropyl nucleic acids.
Chembiochem : a European journal of chemical biology 2005;6(12):2298-304.
2005: Gert Emmerechts; Piet Herdewijn; Jef Rozenski
Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;825(2):233-8.
2005: Kristof Van Hecke; Koen Uytterhoeven; Sergey N Mikhailov; Piet Herdewijn; Luc Van Meervelt
Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 10):953-5.
2005: Sergey N Mikhailov; Ekaterina V Efimtseva; Andrei A Rodionov; Alexandra A Shelkunova; Jef Rozenski; Gert Emmerechts; Guy Schepers; Arthur Van Aerschot; Piet Herdewijn
Synthesis of RNA containing O-beta-D-ribofuranosyl-(1''-2')-adenosine-5''-phosphate and 1-methyladenosine, minor components of tRNA.
Chemistry & biodiversity 2005;2(9):1153-63.
2005: Matheus Froeyen; Piet Herdewijn
Correct bond order assignment in a molecular framework using integer linear programming with application to molecules where only non-hydrogen atom coordinates are available.
Journal of chemical information and modeling 2005;45(5):1267-74.
2005: Irene M Lagoja; Piet Herdewijn
A potential prebiotic route to adenine from hypoxanthine.
Chemistry & biodiversity 2005;2(7):923-7.
2005: Patrick Chaltin; Anca Margineanu; Damien Marchand; Arthur Van Aerschot; Jef Rozenski; Frans C De Schryver; Andreas Herrmann; Klaus Müllen; Rudy L Juliano; Michael H Fisher; Hyunmin Kang; Steven De Feyter; Piet Herdewijn
Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids.
Bioconjugate chemistry 2005;16(4):827-36.
2005: Sara Vijgen; Koen Nauwelaerts; Jing Wang; Arthur Van Aerschot; Irene M Lagoja; Piet Herdewijn
Synthesis and conformational analysis of a ribo-type cyclohexenyl nucleoside.
The Journal of organic chemistry 2005;70(12):4591-7.
2005: Koen Robeyns; Piet Herdewijn; Luc Van Meervelt
Oligonucleotides with cyclohexene-nucleoside building blocks: crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 6):585-6.
2005: Tongfei Wu; Matheus Froeyen; Veerle Kempeneers; Christophe Pannecouque; Jing Wang; Roger Busson; Erik De Clercq; Piet Herdewijn
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.
Journal of the American Chemical Society 2005;127(14):5056-65.
2005: Timm Maier; Ingo Przylas; Norbert Strater; Piet Herdewijn; Wolfram Saenger
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.
Journal of the American Chemical Society 2005;127(9):2937-43.
2005: Gaelle Kolb; Sandrine Reigadas; Claudine Boiziau; Arthur Van Aerschot; Andrey A Arzumanov; Michael J Gait; Piet Herdewijn; Jean-Jacques Toulmé
Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.
Biochemistry 2005;44(8):2926-33.
2005: Ping Gu; Guy Schepers; Carsten Griebel; Jef Rozenski; Hans-Joachim Gais; Piet Herdewijn; Arthur Van Aerschot
Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA).
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):993-8.
2005: Veerle Kempeneers; Marleen Renders; Matheus Froeyen; Piet Herdewijn
Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization.
Nucleic acids research 2005;33(12):3828-36.
2005: Koen Nauwelaerts; Eveline Lescrinier; Gert Sclep; Piet Herdewijn
Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides.
Nucleic acids research 2005;33(8):2452-63.
2004: Veerle Vanheusden; Hélène Munier-Lehmann; Matheus Froeyen; Roger Busson; Jef Rozenski; Piet Herdewijn; Serge Van Calenbergh
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Journal of medicinal chemistry 2004;47(25):6187-94.
2004: Kris Morreel; John Ralph; Fachuang Lu; goeminne geert; Roger Busson; Piet Herdewijn; Jan Goeman; Johan Van der Eycken; Wout Boerjan; Eric Messens
Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols.
Plant physiology 2004;136(4):4023-36.
2004: Michihiro Ohno; Stefano Costanzi; Hak-Sung Kim; Veerle Kempeneers; Karen Vastmans; Piet Herdewijn; Savitri Maddileti; Zhan-Guo Gao; T Kendall Harden; Kenneth Alan Jacobson
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.
Bioorganic & medicinal chemistry 2004;12(21):5619-30.
2004: Anna Astriab-Fisher; Michael H Fisher; Rudy L Juliano; Piet Herdewijn
Increased uptake of antisense oligonucleotides by delivery as double stranded complexes.
Biochemical pharmacology 2004;68(3):403-7.
2004: Veerle Vanheusden; Roger Busson; Piet Herdewijn; Serge Van Calenbergh
Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine.
The Journal of organic chemistry 2004;69(13):4446-53.
2004: AS Golubeva; Boris S Ermolinsky; Ekaterina V Efimtseva; Vera L Tunitskaya; Arthur Van Aerschot; Piet Herdewijn; Sergey N Mikhailov; Sergey N Kochetkov
Interaction of HIV-1 reverse transcriptase with modified oligonucleotide primers containing 2'-O-beta-D-ribofuranosyladenosine.
Biochemistry. Biokhimii͡a 2004;69(2):130-6.
2004: Tongfei Wu; Matheus Froeyen; Guy Schepers; Kristof Mullens; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties.
Organic letters 2004;6(1):51-4.
2004: Veerle Kempeneers; Matheus Froeyen; Karen Vastmans; Piet Herdewijn
Influence of threose nucleoside units on the catalytic activity of a hammerhead ribozyme.
Chemistry & biodiversity 2004;1(1):112-23.
2004: Irene M Lagoja; Piet Herdewijn
One-step synthesis of hypoxanthine from glycinamide and diformylurea.
Chemistry & biodiversity 2004;1(1):106-11.
2004: Hyunmin Kang; Michael H Fisher; Dong Xu; Yuko J Miyamoto; Arnaud Marchand; Arthur Van Aerschot; Piet Herdewijn; Rudy L Juliano
Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.
Nucleic acids research 2004;32(14):4411-9.
2004: Michael Abramov; Arnaud Marchand; Agnes Calleja-Marchand; Piet Herdewijn
Synthesis of D-altritol nucleosides with a 3'-O-tert-butyldimethylsilyl protecting group.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):439-55.
2003: Sylvie Pochet; Pierre Alexandre Kaminski; Arthur Van Aerschot; Piet Herdewijn; Philippe Marlière
Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo.
Comptes rendus biologies 2003;326(12):1175-84.
2003: Koen Nauwelaerts; Karen Vastmans; Matheus Froeyen; Veerle Kempeneers; Jef Rozenski; Helmut Rosemeyer; Arthur Van Aerschot; Roger Busson; Jeffrey C Lacey; Ekaterina V Efimtseva; Sergey N Mikhailov; Eveline Lescrinier; Piet Herdewijn
Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.
Nucleic acids research 2003;31(23):6758-69.
2003: Irene M Lagoja; Arnaud Marchand; Arthur Van Aerschot; Piet Herdewijn
Synthesis of 1,5-anhydrohexitol building blocks for oligonucleotide synthesis.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2003;Chapter 1():Unit 1.9.
2003: Veerle Kempeneers; Karen Vastmans; Jef Rozenski; Piet Herdewijn
Recognition of threosyl nucleotides by DNA and RNA polymerases.
Nucleic acids research 2003;31(21):6221-6.
2003: Veerle Vanheusden; Philippe Van Rompaey; Hélène Munier-Lehmann; Sylvie Pochet; Piet Herdewijn; Serge Van Calenbergh
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Bioorganic & medicinal chemistry letters 2003;13(18):3045-8.
2003: Veerle Vanheusden; Hélène Munier-Lehmann; Matheus Froeyen; Laurence Dugué; Arne Heyerick; Denis De Keukeleire; Sylvie Pochet; Roger Busson; Piet Herdewijn; Serge Van Calenbergh
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Journal of medicinal chemistry 2003;46(18):3811-21.
2003: Eveline Lescrinier; Matheus Froeyen; Piet Herdewijn
Difference in conformational diversity between nucleic acids with a six-membered 'sugar' unit and natural 'furanose' nucleic acids.
Nucleic acids research 2003;31(12):2975-89.
2003: Jing Wang; Dolores Viña; Roger Busson; Piet Herdewijn
Stereocontrolled synthesis of ara-type cyclohexenyl nucleosides.
The Journal of organic chemistry 2003;68(11):4499-505.
2003: Jef Rozenski; Karen Vastmans; Arthur Van Aerschot; Piet Herdewijn
Evaluation of capillary HPLC/mass spectrometry as an alternative analysis method for gel electrophoresis of oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1513-6.
2003: Arthur Van Aerschot; Arnaud Marchand; Guy Schepers; W Van den Eynde; Jef Rozenski; Roger Busson; Piet Herdewijn
Methylated hexitol nucleic acids, towards congeners with improved antisense potential.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1227-9.
2003: Sergey N Mikhailov; Ekaterina V Efimtseva; Boris S Ermolinsky; Georgii V Bobkov; OI Andreeva; AS Golubeva; Sergey N Kochetkov; Arthur Van Aerschot; Guy Schepers; Piet Herdewijn
Oligonucleotides containing disaccharide nucleosides: synthesis, physicochemical, and substrate properties.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1117-8.
2003: Ekaterina V Efimtseva; Sergey N Mikhailov; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Chemical incorporation of 1-methyladenosine, minor tRNA component, into oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1113-5.
2003: Ekaterina V Efimtseva; Alexandra A Shelkunova; Sergey N Mikhailov; Koen Nauwelaerts; Jef Rozenski; Eveline Lescrinier; Piet Herdewijn
Synthesis and conformational properties of O-beta-D-ribofuranosyl-(1''-2')-guanosine and (adenosine)-5''-phosphate.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1109-11.
2003: Arthur Van Aerschot; Guy Schepers; Roger Busson; Johan Neyts; Erik De Clercq; Piet Herdewijn
Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):849-51.
2003: Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Erik De Clercq; Piet Herdewijn
Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):845-7.
2003: Irene M Lagoja; Christophe Pannecouque; Arthur Van Aerschot; Myriam Witvrouw; zeger debyser; Jan Balzarini; Piet Herdewijn; Erik De Clercq
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Journal of medicinal chemistry 2003;46(8):1546-53.
2003: Ekaterina V Efimtseva; Alexandra A Shelkunova; Sergey N Mikhailov; Koen Nauwelaerts; Jef Rozenski; Eveline Lescrinier; Piet Herdewijn
Synthesis and properties of phosphorylated 3'-O-beta-D-ribofuranosyl-2'-deoxythymidine.
Nucleosides, nucleotides & nucleic acids 2003;22(4):359-71.
2003: Irene M Lagoja; Sylvie Pochet; Valerie Boudou; Roy Little; Eveline Lescrinier; Jef Rozenski; Piet Herdewijn
A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides.
The Journal of organic chemistry 2003;68(5):1867-71.
2003: Ahmed Haouz; Veerle Vanheusden; Hélène Munier-Lehmann; Matheus Froeyen; Piet Herdewijn; Serge Van Calenbergh; Marc Delarue
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
The Journal of biological chemistry 2003;278(7):4963-71.
2003: Patrick Chaltin; Filip Borgions; Arthur Van Aerschot; Piet Herdewijn
Comparison of library screening techniques used in the development of dsDNA ligands.
Bioorganic & medicinal chemistry letters 2003;13(1):47-50.
2003: Ping Gu; Guy Schepers; Jef Rozenski; Arthur Van Aerschot; Piet Herdewijn
Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).
Oligonucleotides 2003;13(6):479-89.
2003: Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Erik De Clercq; Piet Herdewijn
Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides.
Antiviral chemistry & chemotherapy 2003;14(1):31-7.
2003: Arthur Van Aerschot; Guy Schepers; Roger Busson; Jef Rozenski; Johan Neyts; Erik De Clercq; Piet Herdewijn
Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation.
Antiviral chemistry & chemotherapy 2003;14(1):23-30.
2002: Oksana M Gritsenko; Elizaveta V Koudan; Sergey N Mikhailov; Boris S Ermolinsky; Arthur Van Aerschot; Piet Herdewijn; Elizaveta S Gromova
Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.
Nucleosides, nucleotides & nucleic acids 2002;21(11-12):753-64.
2002: Zhenyu Zhang; Patrick Chaltin; Arthur Van Aerschot; Jeff Lacey; Jef Rozenski; Roger Busson; Piet Herdewijn
New dsDNA binding unnatural oligopeptides with pyrimidine selectivity.
Bioorganic & medicinal chemistry 2002;10(11):3401-13.
2002: Veerle Vanheusden; Hélène Munier-Lehmann; Sylvie Pochet; Piet Herdewijn; Serge Van Calenbergh
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Bioorganic & medicinal chemistry letters 2002;12(19):2695-8.
2002: David T Manallack; William Pitt; Piet Herdewijn; Jan Balzarini; Erik De Clercq; Mark R Sanderson; Maninder Sohi; Frank Wien; Hélène Munier-Lehmann; Ahmed Haouz; Marc Delarue
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
Journal of enzyme inhibition and medicinal chemistry 2002;17(3):167-74.
2002: Karen Vastmans; Jef Rozenski; Arthur Van Aerschot; Piet Herdewijn
Recognition of HNA and 1,5-anhydrohexitol nucleotides by DNA metabolizing enzymes.
Biochimica et biophysica acta 2002;1597(1):115-22.
2002: Serge Van Calenbergh; Andreas Link; Shelly Fujikawa; Rianne A F de Ligt; Veerle Vanheusden; Abolfasl Golisade; Norbert Blaton; Jef Rozenski; Adriaan P IJzerman; Piet Herdewijn
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.
Journal of medicinal chemistry 2002;45(9):1845-52.
2002: Mads D Sørensen; Lisbet Kvaernø; Torsten Bryld; Anders E Håkansson; Birgit Verbeure; Gilles Gaubert; Piet Herdewijn; Jesper Wengel
alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties.
Journal of the American Chemical Society 2002;124(10):2164-76.
2002: Birgit Verbeure; Carl Jeff Lacey; Matheus Froeyen; Jef Rozenski; Piet Herdewijn
Synthesis and cleavage experiments of oligonucleotide conjugates with a diimidazole-derived catalytic center.
Bioconjugate chemistry 2002;13(2):333-50.
2002: Sergey N Mikhailov; Jef Rozenski; Ekaterina V Efimtseva; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Chemical incorporation of 1-methyladenosine into oligonucleotides.
Nucleic acids research 2002;30(5):1124-31.
2002: OI Andreeva; AS Golubeva; Sergey N Kochetkov; Arthur Van Aerschot; Piet Herdewijn; Ekaterina V Efimtseva; Boris S Ermolinsky; Sergey N Mikhailov
An additional 2'-ribofuranose residue at a specific position of the DNA primer prevents Its elongation by HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2002;12(4):681-4.
2002: Ruben Declercq; Arthur Van Aerschot; Randy J Read; Piet Herdewijn; Luc Van Meervelt
Crystal structure of double helical hexitol nucleic acids.
Journal of the American Chemical Society 2002;124(6):928-33.
2002: Steven De Jonghe; Inge Lamote; Krishnan Venkataraman; Swetlana Boldin-Adamsky; Ulrik Hillaert; Jef Rozenski; Chris Hendrix; Roger Busson; Denis De Keukeleire; Serge Van Calenbergh; Anthony H Futerman; Piet Herdewijn
Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons.
The Journal of organic chemistry 2002;67(3):988-96.
2002: Sofie Gijsbers; Stanny Asselberghs; Piet Herdewijn; Paul P Van Veldhoven
1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.
Biochimica et biophysica acta 2002;1580(1):1-8.
2002: Jef Rozenski; Patrick Chaltin; Arthur Van Aerschot; Piet Herdewijn
Characterization and sequence confirmation of unnatural amino acid containing peptide libraries using electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2002;16(10):982-7.
2002: B S Ermolinskiĭ; M V Fomicheva; Ekaterina V Efimtseva; S N Mikhaĭlov; D S Esipov; EF Boldyreva; Vyacheslav G Korobko; Arthur Van Aerschot; Piet Herdewijn
[Modified oligonucleotides containing 1-beta-D-galactopyranosylthymine: synthesis and substrate properties].
Bioorganicheskaia khimiia 2002;28(1):56-63.
2001: Luk Kerremans; Guy Schepers; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Hybridization between "six-membered" nucleic acids: RNA as a universal information system.
Organic letters 2001;3(26):4129-32.
2001: Birgit Verbeure; Eveline Lescrinier; Jing Wang; Piet Herdewijn
RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA).
Nucleic acids research 2001;29(24):4941-7.
2001: Jing Wang; Jordi Morral; C Hendrix; Piet Herdewijn
A straightforward stereoselective synthesis of D- and L-5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine.
The Journal of organic chemistry 2001;66(25):8478-82.
2001: Matheus Froeyen; Eveline Lescrinier; Luk Kerremans; Helmut Rosemeyer; Frank Seela; Birgit Verbeure; Irene M Lagoja; Jef Rozenski; Arthur Van Aerschot; Roger Busson; Piet Herdewijn
Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(23):5183-94.
2001: Arthur Van Aerschot; M Meldgaard; Guy Schepers; F Volders; Jef Rozenski; Roger Busson; Piet Herdewijn
Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners.
Nucleic acids research 2001;29(20):4187-94.
2001: IN Lavrik; Olga N Avdeeva; Olga A Dontsova; M Froeyen; Piet Herdewijn
Translational properties of mHNA, a messenger RNA containing anhydrohexitol nucleotides.
Biochemistry 2001;40(39):11777-84.
2001: Karen Vastmans; Matheus Froeyen; Luk Kerremans; Sylvie Pochet; Piet Herdewijn
Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides.
Nucleic acids research 2001;29(15):3154-63.
2001: Piet Herdewijn; Erik De Clercq
The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides.
Bioorganic & medicinal chemistry letters 2001;11(12):1591-7.
2001: Jing Wang; Birgit Verbeure; I Luyten; Matheus Froeyen; C Hendrix; Helmut Rosemeyer; Frank Seela; Arthur Van Aerschot; Piet Herdewijn
Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):785-8.
2001: Arthur Van Aerschot; M Meldgaard; F Volders; Guy Schepers; Jef Rozenski; Piet Herdewijn
Increased RNA affinity of HNA analogues by introducing alkoxy substituents at the C-1 or C-3 position.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):781-4.
2001: Jing Wang; Matheus Froeyen; C Hendrix; C Andrei; Robert Snoeck; Eveline Lescrinier; Erik De Clercq; Piet Herdewijn
(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):727-30.
2001: C Cheng; L Ma; H Miyajima; Piet Herdewijn
A neural network to predict melting temperature (Tm) of RNA duplex.
Nucleosides, nucleotides & nucleic acids 2001;20(3):261-9.
2001: Mads D Sørensen; Lisbet Kvaernø; Torsten Bryld; Anders E Håkansson; Lise Keinicke; Birgit Verbeure; Piet Herdewijn; Jesper Wengel
The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid).
Nucleic acids research. Supplement (2001) 2001;(1):25-6.
2000: H Meyermans; Kris Morreel; catherine Lapierre; Brigitte Pollet; A De Bruyn; Roger Busson; Piet Herdewijn; Bart Devreese; Jozef Van Beeumen; Jane M Marita; John Ralph; C Chen; B Burggraeve; Marc Van Montagu; Eric Messens; Wout Boerjan
Modifications in lignin and accumulation of phenolic glucosides in poplar xylem upon down-regulation of caffeoyl-coenzyme A O-methyltransferase, an enzyme involved in lignin biosynthesis.
The Journal of biological chemistry 2000;275(47):36899-909.
2000: I Van Overmeire; Swetlana Boldin-Adamsky; Krishnan Venkataraman; Rivka Zisling; Steven De Jonghe; Serge Van Calenbergh; Denis De Keukeleire; Anthony H Futerman; Piet Herdewijn
Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.
Journal of medicinal chemistry 2000;43(22):4189-99.
2000: Karen Vastmans; Sylvie Pochet; A Peys; Luk Kerremans; Arthur Van Aerschot; C Hendrix; Philippe Marlière; Piet Herdewijn
Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides.
Biochemistry 2000;39(42):12757-65.
2000: Andrei A Rodionov; Ekaterina V Efimtseva; Sergey N Mikhailov; Jef Rozenski; I Luyten; Piet Herdewijn
Synthesis and properties of O-beta-D-ribofuranosyl-(1"-2')-adenosine-5"-O-phosphate and its derivatives.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1847-59.
2000: Oksana M Gritsenko; Sergey N Mikhailov; Ekaterina V Efimtseva; Arthur Van Aerschot; Piet Herdewijn; Elizaveta S Gromova
Probing the MVAI methyltransferase region that interacts with DNA: affinity labeling with the dialdehyde-containing DNA duplexes.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1805-20.
2000: Eveline Lescrinier; R Esnouf; J Schraml; Roger Busson; H Heus; C Hilbers; Piet Herdewijn
Solution structure of a HNA-RNA hybrid.
Chemistry & biology 2000;7(9):719-31.
2000: D Atkins; M Miller; B De Bouvere; Arthur Van Aerschot; Piet Herdewijn
Evaluation of the cellular uptake of hexitol nucleic acids in HeLa cells.
Die Pharmazie 2000;55(8):615-7.
2000: Piet Herdewijn
Heterocyclic modifications of oligonucleotides and antisense technology.
Antisense & nucleic acid drug development 2000;10(4):297-310.
2000: Nandanan Erathodiyil; SY Jang; Stefano Moro; Hea Ok Kim; M A Siddiqui; P Russ; Victor E Marquez; R Busson; Piet Herdewijn; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
Journal of medicinal chemistry 2000;43(5):829-42.
2000: Jing Wang; Matheus Froeyen; C Hendrix; G Andrei; Robert Snoeck; Erik De Clercq; Piet Herdewijn
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
Journal of medicinal chemistry 2000;43(4):736-45.
2000: G N Thoithi; Ann Van Schepdael; Roger Busson; G Janssen; Arthur Van Aerschot; Piet Herdewijn; Eugène Roets; Jos Hoogmartens
Investigation of the kinetics of degradation of hexopyranosylated cytosine nucleosides using liquid chromatography.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):189-203.
2000: IA Kozlov; M Zielinski; B Allart; Luk Kerremans; Arthur Van Aerschot; Roger Busson; Piet Herdewijn; Leslie E Orgel
Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(1):151-5.
1999: Piet Herdewijn
Conformationally restricted carbohydrate-modified nucleic acids and antisense technology.
Biochimica et biophysica acta 1999;1489(1):167-79.
1999: Steven De Jonghe; I Van Overmeire; S Poulton; Chris Hendrix; Roger Busson; Serge Van Calenbergh; Denis De Keukeleire; S Spiegel; Piet Herdewijn
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.
Bioorganic & medicinal chemistry letters 1999;9(21):3175-80.
1999: Steven De Jonghe; I Van Overmeire; J Gunst; A De Bruyn; Chris Hendrix; Serge Van Calenbergh; Roger Busson; Denis De Keukeleire; Jan Philippé; Piet Herdewijn
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
Bioorganic & medicinal chemistry letters 1999;9(21):3159-64.
1999: Serge Van Calenbergh; Andreas Link; Conrad Kunick; Piet Herdewijn
Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.
Die Pharmazie 1999;54(10):727-9.
1999: I Van Overmeire; Swetlana Boldin-Adamsky; F Dumont; Serge Van Calenbergh; G Slegers; Denis De Keukeleire; Anthony H Futerman; Piet Herdewijn
Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.
Journal of medicinal chemistry 1999;42(14):2697-705.
1999: Marleen Maras; A De Bruyn; Wouter Vervecken; J Uusitalo; Merja Penttilä; Roger Busson; Piet Herdewijn; Roland Contreras
In vivo synthesis of complex N-glycans by expression of human N-acetylglucosaminyltransferase I in the filamentous fungus Trichoderma reesei.
FEBS letters 1999;452(3):365-70.
1999: Nandanan Erathodiyil; E Camaioni; SY Jang; YC Kim; Gloria Cristalli; Piet Herdewijn; John A Secrist; Kamal N Tiwari; A Mohanram; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
Journal of medicinal chemistry 1999;42(9):1625-38.
1999: Sergey N Mikhailov; Andrei A Rodionov; Ekaterina V Efimtseva; Boris S Ermolinsky; M V Fomitcheva; N S Padyukova; K Rothenbacher; Eveline Lescrinier; Piet Herdewijn
Studies on disaccharide nucleoside synthesis. Mechanism of the formation of trisaccharide purine nucleosides.
Nucleosides & nucleotides 1999;18(4-5):691-2.
1999: V Boudou; Luk Kerremans; B De Bouvere; Eveline Lescrinier; Guy Schepers; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety.
Nucleic acids research 1999;27(6):1450-6.
1999: Vera L Tunitskaya; EE Rusakova; LV Memelova; Sergey N Kochetkov; Arthur Van Aerschot; Piet Herdewijn; Ekaterina V Efimtseva; Boris S Ermolinsky; Sergey N Mikhailov
Mapping of T7 RNA polymerase active site with novel reagents--oligonucleotides with reactive dialdehyde groups.
FEBS letters 1999;442(1):20-4.
1999: IA Kozlov; B De Bouvere; Arthur Van Aerschot; Piet Herdewijn; Leslie E Orgel
Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.
Journal of the American Chemical Society 1999;121(25):5856-9.
1999: Ruben Declercq; Arthur Van Aerschot; Piet Herdewijn; Luc Van Meervelt
Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC).
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):279-80.
1998: T Ostrowski; B Wroblowski; Roger Busson; Jef Rozenski; Erik De Clercq; MS Bennett; JN Champness; WC Summers; Mark R Sanderson; Piet Herdewijn
5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
Journal of medicinal chemistry 1998;41(22):4343-53.
1998: JN Champness; MS Bennett; Frank Wien; R Visse; WC Summers; Piet Herdewijn; E de Clerq; T Ostrowski; R L Jarvest; Mark R Sanderson
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins 1998;32(3):350-61.
1997: Serge Van Calenbergh; J K von Frijtag Drabbe Künzel; Norbert Blaton; Oswald M Peeters; Jef Rozenski; A Van Aerschot; A De Bruyn; Denis De Keukeleire; Adriaan P IJzerman; Piet Herdewijn
N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.
Journal of medicinal chemistry 1997;40(23):3765-72.
1997: G Thoithi; Ann Van Schepdael; Piet Herdewijn; Eugène Roets; Jos Hoogmartens
Liquid chromatographic separation of hexopyranosylated cytosine nucleosides from their degradation products.
Journal of pharmaceutical and biomedical analysis 1997;16(3):533-40.
1997: MG Brevnov; Oksana M Gritsenko; Sergey N Mikhailov; Ekaterina V Efimtseva; Boris S Ermolinsky; Arthur Van Aerschot; Piet Herdewijn; A V Repyk; Elizaveta S Gromova
DNA duplexes with reactive dialdehyde groups as novel reagents for cross-linking to restriction- modification enzymes.
Nucleic acids research 1997;25(16):3302-9.
1997: K Croes; Minne Casteels; Stanny Asselberghs; Piet Herdewijn; Guy P Mannaerts; Paul P Van Veldhoven
Formation of a 2-methyl-branched fatty aldehyde during peroxisomal alpha-oxidation.
FEBS letters 1997;412(3):643-5.
1997: M Marangoni; Arthur Van Aerschot; P Augustyns; Jef Rozenski; Piet Herdewijn
Synthesis and hybridization properties of inverse oligonucleotides.
Nucleic acids research 1997;25(15):3034-41.
1997: Marleen Maras; A De Bruyn; J Schraml; Piet Herdewijn; Marc Claeyssens; Walter Fiers; Roland Contreras
Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.
European journal of biochemistry / FEBS 1997;245(3):617-25.
1997: Ignace Samson; Jef Rozenski; Bart Samyn; A Van Aerschot; Jozef Van Beeumen; Piet Herdewijn
Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei.
The Journal of biological chemistry 1997;272(17):11378-83.
1997: A De Bruyn; Marleen Maras; J Schraml; Piet Herdewijn; Roland Contreras
NMR evidence for a novel asparagine-linked oligosaccharide on cellobiohydrolase I from Trichoderma reesei RUTC 30.
FEBS letters 1997;405(1):111-3.
1997: Anja Wuyts; Nancy Van Osselaer; Annemie Haelens; Ignace Samson; Piet Herdewijn; A Ben-Baruch; J J Oppenheim; Paul Proost; Jo Van Damme
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties.
Biochemistry 1997;36(9):2716-23.
1997: W Saeyens; Denis De Keukeleire; Piet Herdewijn; A De Bruyn
Access to sterically confined nucleoside analogues via intramolecular photocycloadditions of arene-alkene trichromophores.
Biomedical chromatography : BMC 1997;11(2):79-80.
1996: H De Winter; Piet Herdewijn
Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Journal of medicinal chemistry 1996;39(24):4727-37.
1996: I Creuven; C Evrard; A Olivier; G Evrard; Arthur Van Aerschot; piet wigerinck; Piet Herdewijn; François Durant
Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.
Antiviral research 1996;30(2-3):63-74.
1996: C Hendrix; Jozef Anne; B Joris; Arthur Van Aerschot; Piet Herdewijn
Selection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA.
The Biochemical journal 1996;314 ( Pt 2)():655-61.
1996: Piet Herdewijn
Antisense oligonucleotides.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1996;58(4):359-81.
1995: Arthur Van Aerschot; Jef Rozenski; D Loakes; N Pillet; G Schepers; Piet Herdewijn
An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside.
Nucleic acids research 1995;23(21):4363-70.
1995: Serge Van Calenbergh; Christophe Verlinde; J Soenens; A De Bruyn; Mia callens; Norbert Blaton; Oswald M Peeters; Jef Rozenski; Wim G J Hol; Piet Herdewijn
Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.
Journal of medicinal chemistry 1995;38(19):3838-49.
1995: C Hendrix; M Mahieu; Jozef Anne; Serge Van Calenbergh; Arthur Van Aerschot; J Content; Piet Herdewijn
Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides.
Biochemical and biophysical research communications 1995;210(1):67-73.
1995: Ignace Samson; L Kerremans; Jef Rozenski; Bart Samyn; J Van Beeumen; Arthur Van Aerschot; Piet Herdewijn
Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.
Bioorganic & medicinal chemistry 1995;3(3):257-65.
1995: C Hendrix; Bart Devreese; Jef Rozenski; Arthur Van Aerschot; A De Bruyn; J Van Beeumen; Piet Herdewijn
Incorporation of 2'-amido-nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates.
Nucleic acids research 1995;23(1):51-7.
1995: Piet Herdewijn
[Structure-activity relation study of anti-herpes associations with a 2'-deoxyuridine basic structure].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1995;57(6):601-15.
1994: Christophe Verlinde; Mia callens; Serge Van Calenbergh; Arthur Van Aerschot; Piet Herdewijn; Véronique Hannaert; Paul A M Michels; Fred R Opperdoes; Wim G J Hol
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.
Journal of medicinal chemistry 1994;37(21):3605-13.
1994: A Olivier; I Creuven; C Evrard; G Evrard; M Dory; Arthur Van Aerschot; piet wigerinck; Piet Herdewijn; François Durant
Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.
Antiviral research 1994;24(4):289-304.
1994: C Bohman; Jan Balzarini; piet wigerinck; Arthur Van Aerschot; Piet Herdewijn; E De Clercq
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
The Journal of biological chemistry 1994;269(11):8036-43.
1993: Jan Balzarini; A Karlsson; L Wang; C Bohman; K Horská; Ivan Votruba; A Fridland; Arthur Van Aerschot; Piet Herdewijn; E De Clercq
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
The Journal of biological chemistry 1993;268(33):24591-8.
1993: Koen Augustyns; G Godard; C Hendrix; Arthur Van Aerschot; Jef Rozenski; TE Saison-Behmoaras; Piet Herdewijn
Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides.
Nucleic acids research 1993;21(20):4670-6.
1993: Arthur Van Aerschot; P Mamos; N J Weyns; S Ikeda; E De Clercq; Piet Herdewijn
Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
Journal of medicinal chemistry 1993;36(20):2938-42.
1993: I Verheggen; Arthur Van Aerschot; S Toppet; Robert Snoeck; G Janssen; Jan Balzarini; E De Clercq; Piet Herdewijn
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
Journal of medicinal chemistry 1993;36(14):2033-40.
1993: Ann Van Schepdael; N Ossembe; Piet Herdewijn; Eugène Roets; Jos Hoogmartens
Liquid chromatographic study of the stability of 5-halogeno-2'-deoxyuridines.
Journal of pharmaceutical and biomedical analysis 1993;11(4-5):345-51.
1993: piet wigerinck; L Kerremans; P Claes; Robert Snoeck; P Maudgal; E De Clercq; Piet Herdewijn
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
Journal of medicinal chemistry 1993;36(5):538-43.
1992: Koen Augustyns; F Vandendriessche; Arthur Van Aerschot; Roger Busson; C Urbanke; Piet Herdewijn
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.
Nucleic acids research 1992;20(18):4711-6.
1992: Piet Herdewijn
Novel nucleoside strategies for anti-HIV and anti-HSV therapy.
Antiviral research 1992;19(1):1-14.
1992: F Vandendriessche; Robert Snoeck; G Janssen; Jos Hoogmartens; Arthur Van Aerschot; E De Clercq; Piet Herdewijn
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
Journal of medicinal chemistry 1992;35(8):1458-65.
1992: H L De Winter; Camiel J De Ranter; Norbert Blaton; Oswald M Peeters; Arthur Van Aerschot; Piet Herdewijn
1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 1)():95-103.
1992: Piet Herdewijn
[Development of new enzyme inhibitors for the treatment of AIDS[ ].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1992;54(2):139-53.
1991: Jan Balzarini; C K Lee; Piet Herdewijn; E De Clercq
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus.
The Journal of biological chemistry 1991;266(32):21509-14.
1991: piet wigerinck; Christophe Pannecouque; Robert Snoeck; P Claes; E De Clercq; Piet Herdewijn
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Journal of medicinal chemistry 1991;34(8):2383-9.
1991: piet wigerinck; Robert Snoeck; P Claes; E De Clercq; Piet Herdewijn
Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
Journal of medicinal chemistry 1991;34(6):1767-72.
1991: Jan Balzarini; A Holy; J Jindrich; H Dvorakova; Z Hao; Robert Snoeck; Piet Herdewijn; D G Johns; E De Clercq
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4961-5.
1991: Koen Augustyns; Arthur Van Aerschot; Ann Van Schepdael; C Urbanke; Piet Herdewijn
Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
Nucleic acids research 1991;19(10):2587-93.
1991: Jan Balzarini; Z Hao; Piet Herdewijn; D G Johns; E De Clercq
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1499-503.
1991: Koen Augustyns; F Vandendriessche; Arthur Van Aerschot; Piet Herdewijn
Synthesis of oligonucleotides modified in the sugar moiety.
Nucleic acids symposium series 1991;(24):224.
1990: Arthur Van Aerschot; D Everaert; G Gosselin; Oswald M Peeters; Norbert Blaton; Camiel J De Ranter; J L Imbach; Jan Balzarini; E De Clercq; Piet Herdewijn
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
Antiviral research 1990;14(6):357-69.
1990: L Jie; Arthur Van Aerschot; Jan Balzarini; G Janssen; Roger Busson; Jos Hoogmartens; E De Clercq; Piet Herdewijn
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.
Journal of medicinal chemistry 1990;33(9):2481-7.
1990: piet wigerinck; Arthur Van Aerschot; G Janssen; P Claes; Jan Balzarini; E De Clercq; Piet Herdewijn
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.
Journal of medicinal chemistry 1990;33(2):868-73.
1989: Jan Balzarini; Arthur Van Aerschot; Piet Herdewijn; E De Clercq
2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent.
Biochemical and biophysical research communications 1989;164(3):1190-7.
1989: Arthur Van Aerschot; Piet Herdewijn; G Janssen; M Cools; E De Clercq
Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.
Antiviral research 1989;12(3):133-50.
1989: Morris J Robins; S G Wood; N K Dalley; Piet Herdewijn; Jan Balzarini; E De Clercq
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides.
Journal of medicinal chemistry 1989;32(8):1763-8.
1989: Arthur Van Aerschot; Piet Herdewijn; Jan Balzarini; Rudi Pauwels; E De Clercq
3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.
Journal of medicinal chemistry 1989;32(8):1743-9.
1989: Jan Balzarini; Arthur Van Aerschot; Rudi Pauwels; M Baba; Dominique Schols; Piet Herdewijn; E De Clercq
5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.
Molecular pharmacology 1989;35(5):571-7.
1989: Jan Balzarini; Piet Herdewijn; E De Clercq
Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo.
Antiviral research 1989;11(4):161-71.
1989: Jan Balzarini; Piet Herdewijn; E De Clercq
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
The Journal of biological chemistry 1989;264(11):6127-33.
1989: Jan Balzarini; Arthur Van Aerschot; Piet Herdewijn; E de Clercq
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.
Biochemical pharmacology 1989;38(6):869-74.
1989: Jan Balzarini; Lieve Naesens; Piet Herdewijn; I Rosenberg; A Holy; Rudi Pauwels; M Baba; D G Johns; E De Clercq
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):332-6.
1988: Piet Herdewijn; Jan Balzarini; M Baba; Rudi Pauwels; Arthur Van Aerschot; G Janssen; E De Clercq
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
Journal of medicinal chemistry 1988;31(10):2040-8.
1988: Rudi Pauwels; Jan Balzarini; M Baba; Robert Snoeck; Dominique Schols; Piet Herdewijn; Jan Desmyter; E De Clercq
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
Journal of virological methods 1988;20(4):309-21.
1988: Jan Balzarini; M Baba; Rudi Pauwels; Piet Herdewijn; E De Clerq
Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues.
Biochemical pharmacology 1988;37(14):2847-56.
1988: Jan Balzarini; Piet Herdewijn; Rudi Pauwels; S Broder; E De Clercq
Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity.
Biochemical pharmacology 1988;37(12):2395-403.
1988: Rudi Pauwels; M Baba; Jan Balzarini; Piet Herdewijn; Jan Desmyter; M J Robins; R M Zou; D Madej; E De Clercq
Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside.
Biochemical pharmacology 1988;37(7):1317-25.
1988: Jan Balzarini; M Baba; Rudi Pauwels; Piet Herdewijn; S G Wood; M J Robins; E de Clercq
Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus.
Molecular pharmacology 1988;33(3):243-9.
1988: Jan Balzarini; Rudi Pauwels; M Baba; Piet Herdewijn; E de Clercq; S Broder; D G Johns
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
Biochemical pharmacology 1988;37(5):897-903.
1987: Piet Herdewijn; Rudi Pauwels; M Baba; Jan Balzarini; E De Clercq
Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.
Journal of medicinal chemistry 1987;30(11):2131-7.
1987: M Baba; Rudi Pauwels; Jan Balzarini; Piet Herdewijn; E De Clercq; Jan Desmyter
Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro.
Antimicrobial agents and chemotherapy 1987;31(10):1613-7.
1987: Rudi Pauwels; E De Clercq; Jan Desmyter; Jan Balzarini; Patrick Goubau; Piet Herdewijn; H Vanderhaeghe; M Vandeputte
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
Journal of virological methods 1987;16(3):171-85.
1987: Jan Balzarini; M J Robins; R M Zou; Piet Herdewijn; E De Clercq
The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.
Biochemical and biophysical research communications 1987;145(1):277-83.
1987: Jan Balzarini; Rudi Pauwels; M Baba; M J Robins; R M Zou; Piet Herdewijn; E De Clercq
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro.
Biochemical and biophysical research communications 1987;145(1):269-76.