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James Herman

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Yan Jia; Yunsheng Yang; Qimin Zhan; Malcolm V Brock; James G Herman; Mingzhou Guo
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.
Rathi N Pillai; Suresh S Ramalingam; Maria J A Ribeiro; You Shaojin; Gabriel L Sica; Vijay A Varma; Liu Yuan; Malcom V Brock; Seth A Brodie; James G Herman; Fadlo R Khuri; Ge Li; Dana C Nickleach; Taofeek K Owonikoko; Dacian Bonta; Johann C Brandes
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.
Joshi J Alumkal; James G Herman
Distinct epigenetic mechanisms distinguish TMPRSS2-ERG fusion-positive and -negative prostate cancers.

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All Publications

2013: Yan Jia; Yunsheng Yang; Qimin Zhan; Malcolm V Brock; James G Herman; Mingzhou Guo
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.
The Journal of pathology 2013;230(2):194-204.
2013: Rathi N Pillai; Suresh S Ramalingam; Maria J A Ribeiro; You Shaojin; Gabriel L Sica; Vijay A Varma; Liu Yuan; Malcom V Brock; Seth A Brodie; James G Herman; Fadlo R Khuri; Ge Li; Dana C Nickleach; Taofeek K Owonikoko; Dacian Bonta; Johann C Brandes
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1603-11.
2012: Joshi J Alumkal; James G Herman
Distinct epigenetic mechanisms distinguish TMPRSS2-ERG fusion-positive and -negative prostate cancers.
Cancer discovery 2012;2(11):979-81.
2012: Yan Jia; Yunsheng Yang; Yuanzi Yu; Qimin Zhan; Xiaofei Zheng; Malcolm V Brock; James G Herman; Mingzhou Guo
Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer.
The Journal of molecular diagnostics : JMD 2012;14(6):577-85.
2012: Xuefeng Liu; Qimin Zhan; Xiaomei Zhang; Malcolm V Brock; James G Herman; Mingzhou Guo
CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer.
Cancer biology & therapy 2012;13(12):1152-7.
2012: Leander Van Neste; Joseph W Bigley; Jonathan I Epstein; James G Herman; Gaëtan Otto; Wim van Criekinge
The epigenetic promise for prostate cancer diagnosis.
The Prostate 2012;72(11):1248-61.
2012: Dongtao Yin; Yuanzi Yu; Malcolm V Brock; Chao Han; James G Herman; Yan Jia; Yang Liu; Xiaomo Su; Mingzhou Guo
SOX17 methylation inhibits its antagonism of Wnt signaling pathway in lung cancer.
Discovery medicine 2012;14(74):33-40.
2012: Jana Jeschke; Alexander Koch; Kornel E Schuebel; Wim van Criekinge; Leander Van Neste; Ilse Vlassenbroeck; Andreas Winterpacht; Stephen B Baylin; Marilia Freitas Calmon; Timothy A Chan; Leslie Cope; Valérie Deregowski; Mashaal Dhir; Edward Gabrielson; Sabine C Glöckner; James G Herman; Craig M Hooker; NITA AHUJA
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen.
Epigenetics : official journal of the DNA Methylation Society 2012;7(7):701-9.
2012: Michael J Hassett; James G Herman; Clifford A Hudis; Melissa E Hughes; Paul Kelly Marcom; Joyce C Niland; Jane E Pettinga; David Share; Samuel M Silver; Richard Theriault; Jonathan L Vandergrift; Douglas W Blayney; Stephen B Edge; Yu-Ning Wong; Jane C Weeks
Adoption of gene expression profile testing and association with use of chemotherapy among women with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(18):2218-26.
2012: Shuguang Leng; Maria A Picchi; Christine A Stidley; Holly J Wolf; Christin M Yingling; Malcolm V Brock; Tim Byers; Kieu Do; William J Feser; Wilbur A Franklin; James G Herman; Timothy C Kennedy; Anna E Baron; Stephen B Baylin; Steven A Belinsky
Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(12):3387-95.
2012: Muriel X G Draht; James G Herman; Gerrit A Meijer; Veerle Melotte; Hanneke Niessen; Robert R Riedl; Beatriz Carvalho; Manon van Engeland; Kim M Smits
Promoter CpG island methylation markers in colorectal cancer: the road ahead.
Epigenomics 2012;4(2):179-94.
2012: Yan Jia; Yazhuo Li; Yunsheng Yang; Yuanzi Yu; Qimin Zhan; Malcolm V Brock; Baoping Cao; James G Herman; Mingzhou Guo
Methylation of TFPI-2 is an early event of esophageal carcinogenesis.
Epigenomics 2012;4(2):135-46.
2012: Shabana Shabbeer; Brian W Simons; Simon A Williams; James G Herman; Michael A Carducci
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence.
Cancer prevention research (Philadelphia, Pa.) 2012;5(2):229-39.
2012: Laura A E Hughes; Piet A van den Brandt; James G Herman; NITA AHUJA; Kim M Smits; Matty P Weijenberg; Daisy Jonkers; Carolina A J Khalid-de Bakker; Manon van Engeland
The CpG island methylator phenotype in colorectal cancer: progress and problems.
Biochimica et biophysica acta 2012;1825(1):77-85.
2011: Rosalyn A Juergens; Beverly Lee; Sara C Murphy; Kristen Rodgers; Michelle A Rudek; Rosa Sebree; Salina D Tsai; Frank P Vendetti; John Wrangle; Ming Zhao; Stephen B Baylin; Steven A Belinsky; Malcolm V Brock; Barbara Coleman; Igor Espinoza Delgado; Noreli Franco; James G Herman; Craig M Hooker; Charles Rudin
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.
Cancer discovery 2011;1(7):598-607.
2011: Mashaal Dhir; Sabine C Glöckner; James G Herman; Christine A Iacobuzio-Donahue; Jana Jeschke; Elizabeth Montgomery; Emmanouil P Pappou; Shinichi Yachida; Leander Van Neste; Stephen B Baylin; NITA AHUJA
Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.
International journal of cancer. Journal international du cancer 2011;129(8):1889-98.
2011: Stefan Wilop; James G Herman; Edgar Jost; Tim H Brümmendorf; Manel Esteller; Agustín F Fernandez; Oliver Galm
Array-based DNA methylation profiling in acute myeloid leukaemia.
British journal of haematology 2011;155(1):65-72.
2011: Stefan Wilop; Tim H Brümmendorf; James G Herman; Edgar Jost; Marjolein H F M Lentjes; Manon van Engeland; Thomas B van Gemmeren; Oliver Galm
Methylation-associated dysregulation of the suppressor of cytokine signaling-3 gene in multiple myeloma.
Epigenetics : official journal of the DNA Methylation Society 2011;6(8):1047-52.
2011: Iris J H van Vlodrop; Marcella M L L Baldewijns; Sarah Derks; James G Herman; Hanneke E C Niessen; Wim van Criekinge; Manon van Engeland
Analysis of promoter CpG island hypermethylation in cancer: location, location, location!
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(13):4225-31.
2011: Helai P Mohammad; H S Prevas; DAVID WATKINS; M Zhang; W Zhang; James G Herman; Craig M Hooker; David L Huso; Baktiar O Karim; B R Leadem; Stephen B Baylin
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Oncogene 2011;30(23):2659-69.
2011: Manon van Engeland; Sarah Derks; Kim M Smits; Gerrit A Meijer; James G Herman
Colorectal cancer epigenetics: complex simplicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(10):1382-91.
2011: Joo-Mi Yi; Mashaal Dhir; Leander Van Neste; Stephanie R Downing; Jana Jeschke; Sabine C Glöckner; Marilia de Freitas Calmon; Craig M Hooker; Juan M Funes; Chris Boshoff; Kim M Smits; Manon van Engeland; Matty P Weijenberg; Christine A Iacobuzio-Donahue; James G Herman; Kornel E Schuebel; Stephen B Baylin; NITA AHUJA
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1535-45.
2011: Rama S Dwivedi; James G Herman; Timothy A McCaffrey; Dominic S C Raj
Beyond genetics: epigenetic code in chronic kidney disease.
Kidney international 2011;79(1):23-32.
2010: Manon van Engeland; James G Herman
Viewing the epigenetics of colorectal cancer through the window of folic acid effects.
Cancer prevention research (Philadelphia, Pa.) 2010;3(12):1509-12.
2010: J D F Licchesi; L Van Neste; V K Tiwari; Leslie Cope; X Lin; Stephen B Baylin; James G Herman
Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc.
Oncogene 2010;29(44):5923-34.
2010: Yan Jia; Yunsheng Yang; Shuang Liu; James G Herman; Fengmin Lu; Mingzhou Guo
SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma.
Epigenetics : official journal of the DNA Methylation Society 2010;5(8):743-9.
2010: Hariharan P Easwaran; Leander Van Neste; Leslie Cope; Subhojit Sen; Helai P Mohammad; Gayle J Pageau; Jeanne B Lawrence; James G Herman; Kornel E Schuebel; Stephen B Baylin
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.
Cancer research 2010;70(20):8015-24.
2010: Jürgen Veeck; Santiago Ropero; Fernando Setien; Eva Gonzalez-Suarez; Ana Osorio; Javier Benitez; James G Herman; Manel Esteller
BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(29):e563-4; author reply e565-6.
2010: Elizabeth A Griffiths; Steven D Gore; Craig M Hooker; Helai P Mohammad; A MICHAEL MCDEVITT; B Douglas Smith; Judith E Karp; James G Herman; Hetty Carraway
Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.
Epigenetics : official journal of the DNA Methylation Society 2010;5(7):590-600.
2010: Elizabeth A Griffiths; Steven D Gore; Craig M Hooker; A MICHAEL MCDEVITT; Judith E Karp; B Douglas Smith; Helai P Mohammad; Ying Ye; James G Herman; Hetty Carraway
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.
Leukemia & lymphoma 2010;51(9):1711-9.
2010: Iris Middeldorf; Oliver Galm; Rainhardt Osieka; Edgar Jost; James G Herman; Stefan Wilop
Sequence of administration and methylation of SOCS3 may govern response to gemtuzumab ozogamicin in combination with conventional chemotherapy in patients with refractory or relapsed acute myelogenous leukemia (AML).
American journal of hematology 2010;85(7):477-81.
2010: Megan A Healey; Staci L Deaton; Jonathan K Alder; Véronique Winnepenninckx; Robert A Casero; James G Herman
Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma.
Epigenetics : official journal of the DNA Methylation Society 2010;5(5):410-21.
2010: Spasenija Savic; Noreli Franco; Bruno Grilli; Audrey Barascud; Michelle Herzog; Beata Bode; Heinz Loosli; Peter Spieler; René Schönegg; Inti Zlobec; Douglas P Clark; James G Herman; Lukas Bubendorf
Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology.
Chest 2010;138(1):137-44.
2010: Vasudev J Bailey; Yi Zhang; Brian P Keeley; Chao Yin; Kristen L Pelosky; Malcolm V Brock; Stephen B Baylin; James G Herman; Tza-Huei Wang
Single-tube analysis of DNA methylation with silica superparamagnetic beads.
Clinical chemistry 2010;56(6):1022-5.
2010: Houtan Noushmehr; Daniel J Weisenberger; Kristin Diefes; Heidi S Phillips; Kanan Pujara; Benjamin P Berman; Fei Pan; Christopher E Pelloski; Erik P Sulman; Krishna P Bhat; Roel G W Verhaak; Katherine A Hoadley; D Neil Hayes; Charles M Perou; Heather K Schmidt; Li Ding; Richard K Wilson; David Van Den Berg; Hui Shen; Henrik Bengtsson; Pierre Neuvial; Leslie Cope; Jonathan Buckley; James G Herman; Stephen B Baylin; Peter W Laird; Kenneth Aldape
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
Cancer cell 2010;17(5):510-22.
2010: W Zhang; X Zeng; K J Briggs; ROBERT BEATY; B Simons; R-W Chiu Yen; M A Tyler; H-C Tsai; Y Ye; G S Gesell; James G Herman; Stephen B Baylin; DAVID WATKINS
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Oncogene 2010;29(17):2467-76.
2010: Iris J H van Vlodrop; Marcella M L Baldewijns; Kim M Smits; Leo J Schouten; Leander van Neste; Wim van Criekinge; Hein van Poppel; Evelyne Lerut; Kornel E Schuebel; NITA AHUJA; James G Herman; Adriaan P de Bruïne; Manon van Engeland
Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma.
The American journal of pathology 2010;176(2):575-84.
2010: Vasudev J Bailey; Brian P Keeley; Yi Zhang; Yi-Ping Ho; Hariharan Easwaran; Malcolm V Brock; Kristen L Pelosky; Hetty Carraway; Stephen B Baylin; James G Herman; Tza-Huei Wang
Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection.
Chembiochem : a European journal of chemical biology 2010;11(1):71-4.
2009: Ying Ye; A MICHAEL MCDEVITT; Mingzhou Guo; Wei Zhang; Oliver Galm; Steven D Gore; Judith E Karp; Jaroslaw P Maciejewski; Jeanne Kowalski; Hua-Ling Tsai; Lukasz Gondek; Hsing-Chen Tsai; Xiaofei Wang; Craig M Hooker; B Douglas Smith; Hetty Carraway; James G Herman
Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies.
Cancer research 2009;69(21):8482-90.
2009: Jörg Tost; James G Herman
Welcome to Epigenomics.
Epigenomics 2009;1(1):1-3.
2009: Jianqing Lin; Jill Gilbert; MICHELLE RUDEK-RENAUT; James Zwiebel; Steven D Gore; Anchalee Jiemjit; Ming Zhao; Sharyn D Baker; Richard F Ambinder; James G Herman; Ross C Donehower; Michael A Carducci
A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6241-9.
2009: Tamer E Fandy; James G Herman; Patrick Kerns; Anchalee Jiemjit; Elizabeth Sugar; Si Ho Choi; Allen S Yang; Timothy Aucott; Tianna Dauses; Rosalie Odchimar-Reissig; Jonathan D Licht; Melanie J McConnell; Chris Nasrallah; Kwang-Hee (Marianne) Kim; Weijia Zhang; Yezou Sun; Anthony J Murgo; Igor Espinoza-Delgado; Katharine Oteiza; Ibitayo Owoeye; Lewis R Silverman; Steven D Gore; Hetty Carraway
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.
Blood 2009;114(13):2764-73.
2009: Charles Rudin; Erika Avila-Tang; Curtis C Harris; James G Herman; Fred R Hirsch; William Pao; Ann Grossbart Schwartz; Kirsi H Vahakangas; Jonathan M Samet
Lung cancer in never smokers: molecular profiles and therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5646-61.
2009: JEAN WANG; Mingzhou Guo; Elizabeth Montgomery; Richard E Thompson; Hilary Cosby; Lisa Hicks; Shelun Wang; James G Herman; Marcia Canto
DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus.
The American journal of gastroenterology 2009;104(9):2153-60.
2009: Edgar Jost; D Gezer; Stefan Wilop; H Suzuki; James G Herman; Rainhardt Osieka; Oliver Galm
Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma.
Cancer letters 2009;281(1):24-31.
2009: Vasudev J Bailey; Hariharan Easwaran; Yi Zhang; Elizabeth Griffiths; Steven A Belinsky; James G Herman; Stephen B Baylin; Hetty Carraway; Tza-Huei Wang
MS-qFRET: a quantum dot-based method for analysis of DNA methylation.
Genome research 2009;19(8):1455-61.
2009: Veerle Melotte; Marjolein H F M Lentjes; Sandra M van den Bosch; Debby M E I Hellebrekers; Joep P J de Hoon; Kim A D Wouters; Kathleen L J Daenen; Iris E J M Partouns-Hendriks; Filip Stessels; joost louwagie; Kim M Smits; Matty P Weijenberg; Silvia Sanduleanu; Carolina A J Khalid-de Bakker; Frank A Oort; Gerrit A Meijer; Daisy M A E Jonkers; James G Herman; Adriaan P de Bruïne; Manon van Engeland
N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer.
Journal of the National Cancer Institute 2009;101(13):916-27.
2009: S de Vogel; Matty P Weijenberg; James G Herman; K A D Wouters; A F P M de Goeij; Piet A van den Brandt; A P de Bruïne; Manon van Engeland
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(7):1216-22.
2009: Debby M E I Hellebrekers; Marjolein H F M Lentjes; Sandra M van den Bosch; Veerle Melotte; Kim A D Wouters; Kathleen L J Daenen; Kim M Smits; Yoshimitsu Akiyama; Yasuhito Yuasa; Silvia Sanduleanu; Carolina A J Khalid-de Bakker; Daisy Jonkers; Matty P Weijenberg; joost louwagie; Wim van Criekinge; Beatriz Carvalho; Gerrit A Meijer; Stephen B Baylin; James G Herman; Adriaan P de Bruïne; Manon van Engeland
GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):3990-7.
2009: Sabine C Glöckner; Mashaal Dhir; Joo-Mi Yi; Kelly E McGarvey; Leander Van Neste; joost louwagie; Timothy Chan; Wolfram Kleeberger; Adriaan P de Bruïne; Kim M Smits; Carolina A J Khalid-de Bakker; Daisy M A E Jonkers; Reinhold W Stockbrügger; Gerrit A Meijer; Frank A Oort; Christine A Iacobuzio-Donahue; Katja Bierau; James G Herman; Stephen B Baylin; Manon Van Engeland; Kornel E Schuebel; NITA AHUJA
Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.
Cancer research 2009;69(11):4691-9.
2009: Sarah Derks; Linda J W Bosch; Hanneke E C Niessen; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Sandra Mongera; J Willem Voncken; Gerrit A Meijer; Adriaan P de Bruïne; James G Herman; Manon van Engeland
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Carcinogenesis 2009;30(6):1041-8.
2009: Ilaria Cavallari; Micol Silic-Benussi; Francesca Rende; Annalisa Martines; Paola Fogar; Daniela Basso; Manuela Della Vella; Sergio Pedrazzoli; James G Herman; Luigi Chieco-Bianchi; Giovanni Esposito; Vincenzo Ciminale; Donna M D'Agostino
Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma.
Genes, chromosomes & cancer 2009;48(5):383-96.
2009: Yi Zhang; Vasudev Bailey; Christopher M Puleo; Hariharan Easwaran; Elizabeth Griffiths; James G Herman; Stephen B Baylin; Tza-Huei Wang
DNA methylation analysis on a droplet-in-oil PCR array.
Lab on a chip 2009;9(8):1059-64.
2009: Michael A Vogelbaum; Brian Berkey; David M Peereboom; David Macdonald; Caterina Giannini; John H Suh; Robert Jenkins; James G Herman; Paul Brown; Deborah T Blumenthal; Christopher Biggs; Christopher Schultz; Minesh Mehta
Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131.
Neuro-oncology 2009;11(2):167-75.
2009: Edgar Jost; Nicole do O; Stefan Wilop; James G Herman; Rainhardt Osieka; Oliver Galm
Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia.
Leukemia research 2009;33(3):443-9.
2009: Hetty Carraway; Shelun Wang; Amanda Blackford; Mingzhou Guo; Penny Powers; Stacie Jeter; Nancy E Davidson; Pedram Argani; Kyle Terrell; James G Herman; Julie R Lange
Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence.
Breast cancer research and treatment 2009;114(2):315-25.
2009: Laura A E Hughes; Piet A van den Brandt; Adriaan P de Bruïne; Kim A D Wouters; Sarah Hulsmans; Angela Spiertz; R Alexandra Goldbohm; Anton F P M de Goeij; James G Herman; Matty P Weijenberg; Manon van Engeland
Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms.
PloS one 2009;4(11):e7951.
2009: Tram Kim Lam; Lisa Gallicchio; Kristina Lindsley; Meredith Shiels; Edward Hammond; XU GUANG TAO; Liwei Chen; Karen Robinson; Laura E Caulfield; James G Herman; Eliseo Guallar; Anthony J Alberg
Cruciferous vegetable consumption and lung cancer risk: a systematic review.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(1):184-95.
2009: Liwei Chen; Lisa Gallicchio; Kristina Boyd-Lindsley; XU GUANG TAO; Karen Robinson; Tram Kim Lam; James G Herman; Laura E Caulfield; Eliseo Guallar; Anthony J Alberg
Alcohol consumption and the risk of nasopharyngeal carcinoma: a systematic review.
Nutrition and cancer 2009;61(1):1-15.
2009: Julien D F Licchesi; James G Herman
Methylation-specific PCR.
Methods in molecular biology (Clifton, N.J.) 2009;507():305-23.
2008: Vijay K Tiwari; Kelly M McGarvey; Julien D F Licchesi; Joyce E Ohm; James G Herman; Dirk Schübeler; Stephen B Baylin
PcG proteins, DNA methylation, and gene repression by chromatin looping.
PLoS biology 2008;6(12):2911-27.
2008: Kim M Smits; Arjen H G Cleven; Matty P Weijenberg; Laura A E Hughes; James G Herman; Adriaan P de Bruïne; Manon van Engeland
Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response.
Pharmacogenomics 2008;9(12):1903-16.
2008: Kiyoshi Misawa; Yo Ueda; Takeharu Kanazawa; Yuki Misawa; Ilwhan Jang; John Chadwick Brenner; Tetsuya Ogawa; Satoru Takebayashi; Reidar A Grenman; James G Herman; Hiroyuki Mineta; Thomas Carey
Epigenetic inactivation of galanin receptor 1 in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7604-13.
2008: Joshi J Alumkal; Zhe Zhang; Elizabeth B Humphreys; Christina Bennett; Leslie A Mangold; Michael A Carducci; Alan W Partin; Elizabeth Garrett-Mayer; Angelo M DeMarzo; James G Herman
Effect of DNA methylation on identification of aggressive prostate cancer.
Urology 2008;72(6):1234-9.
2008: Mingzhou Guo; Jingli Ren; Malcolm V Brock; James G Herman; Hetty Carraway
Promoter methylation of HIN-1 in the progression to esophageal squamous cancer.
Epigenetics : official journal of the DNA Methylation Society 2008;3(6):336-41.
2008: Christin L Hanigan; Manon Van Engeland; Adriaan P De Bruine; Kim A Wouters; Matty P Weijenberg; James R Eshleman; James G Herman
An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.
Gastroenterology 2008;135(5):1654-1664.e2.
2008: Joo-Mi Yi; Hsing-Chen Tsai; Sabine C Glöckner; Steven Lin; Joyce E Ohm; Hari Easwaran; C David James; Joseph F Costello; Gregory J Riggins; Charles G Eberhart; John Laterra; Angelo L Vescovi; NITA AHUJA; James G Herman; Kornel E Schuebel; Stephen B Baylin
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.
Cancer research 2008;68(19):8094-103.
2008: Mashaal Dhir; Elizabeth Montgomery; Sabine C Glöckner; Kornel E Schuebel; Craig M Hooker; James G Herman; Stephen B Baylin; Susan L Gearhart; NITA AHUJA
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(10):1745-53.
2008: Monika E Hegi; Lili Liu; James G Herman; Roger Stupp; Wolfgang Wick; Michael Weller; Minesh Mehta; Mark R Gilbert
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(25):4189-99.
2008: Edgar Jost; J Schmid; Stefan Wilop; C Schubert; H Suzuki; James G Herman; R Osieka; Oliver Galm
Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia.
British journal of haematology 2008;142(5):745-53.
2008: Ismail Celik; Lisa Gallicchio; Kristina Boyd; Tram K Lam; Genevieve M Matanoski; XU GUANG TAO; Meredith Shiels; Edward Hammond; Liwei Chen; Karen Robinson; Laura E Caulfield; James G Herman; Eliseo Guallar; Anthony J Alberg
Arsenic in drinking water and lung cancer: a systematic review.
Environmental research 2008;108(1):48-55.
2008: Lisa Gallicchio; Kristina Boyd; Genevieve M Matanoski; XU GUANG TAO; Liwei Chen; Tram K Lam; Meredith Shiels; Edward Hammond; Karen Robinson; Laura E Caulfield; James G Herman; Eliseo Guallar; Anthony J Alberg
Carotenoids and the risk of developing lung cancer: a systematic review.
The American journal of clinical nutrition 2008;88(2):372-83.
2008: Kelly M McGarvey; Leander Van Neste; Leslie Cope; Joyce E Ohm; James G Herman; Wim van Criekinge; Kornel E Schuebel; Stephen B Baylin
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.
Cancer research 2008;68(14):5753-9.
2008: Anchalee Jiemjit; James G Herman; K A Bailey; Stephen B Baylin; Hetty Carraway; Tamer E Fandy; Steven D Gore
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
Oncogene 2008;27(25):3615-23.
2008: Timothy Chan; Sabine Glockner; Joo-Mi Yi; Wei Chen; Leander Van Neste; Leslie Cope; James G Herman; Victor E Velculescu; Kornel E Schuebel; NITA AHUJA; Stephen B Baylin
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
PLoS medicine 2008;5(5):e114.
2008: Julien D F Licchesi; William H Westra; Craig M Hooker; James G Herman
Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2570-8.
2008: Julien D F Licchesi; William H Westra; Craig M Hooker; Emi O Machida; Stephen B Baylin; James G Herman
Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.
Carcinogenesis 2008;29(5):895-904.
2008: Wei Zhang; Sabine C Glöckner; Mingzhou Guo; Emi Ota Machida; David H Wang; Hariharan Easwaran; Leander Van Neste; James G Herman; Kornel E Schuebel; DAVID WATKINS; NITA AHUJA; Stephen B Baylin
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
Cancer research 2008;68(8):2764-72.
2008: Malcolm V Brock; Craig M Hooker; Emi Ota-Machida; Yu Han; Mingzhou Guo; Stephen Ames; Sabine Glöckner; Steven Piantadosi; Edward Gabrielson; Genevieve Pridham; Kristen Pelosky; Steven A Belinsky; Stephen C Yang; Stephen B Baylin; James G Herman
DNA methylation markers and early recurrence in stage I lung cancer.
The New England journal of medicine 2008;358(11):1118-28.
2008: Sarah Derks; Cindy Postma; Beatriz Carvalho; Sandra M van den Bosch; Peter Moerkerk; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.
Carcinogenesis 2008;29(2):434-9.
2007: Hirohide Yoshikawa; Kenichi Matsubara; Xiaoling Zhou; Shu Okamura; Takahiko Kubo; Yaeko Murase; Yuko Shikauchi; Manel Esteller; James G Herman; Xin Wei Wang; Curtis C Harris
WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.
Molecular biology of the cell 2007;18(11):4292-303.
2007: Byungwoo Ryu; Dave S Kim; Amena M DeLuca; Megan A Healey; Shariff Dunlap; Mary Jo Fackler; James G Herman; Rhoda M Alani
Id1 expression is transcriptionally regulated in radial growth phase melanomas.
International journal of cancer. Journal international du cancer 2007;121(8):1705-9.
2007: BAOJIN FU; Mingzhou Guo; Shelun Wang; Domenico Campagna; Mingde Luo; James G Herman; Christine A Iacobuzio-Donahue
Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types.
Cancer biology & therapy 2007;6(10):1546-52.
2007: Mingzhou Guo; Michael G House; Hiromu Suzuki; Ying Ye; Malcolm V Brock; Fengmin Lu; Zhihua Liu; Anil K Rustgi; James G Herman
Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.
International journal of cancer. Journal international du cancer 2007;121(6):1219-26.
2007: Johann C Brandes; Hetty Carraway; James G Herman
Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter.
Oncogene 2007;26(42):6229-37.
2007: Kornel E Schuebel; Wei Chen; Leslie Cope; Sabine C Glöckner; Hiromu Suzuki; Joo-Mi Yi; Timothy Chan; Leander Van Neste; Wim van Criekinge; Sandra van den Bosch; Manon van Engeland; Angela H Ting; Kam-Wing Jair; Wayne Yu; Minoru Toyota; Kohzoh Imai; NITA AHUJA; James G Herman; Stephen B Baylin
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
PLoS genetics 2007;3(9):1709-23.
2007: Debby M E I Hellebrekers; Veerle Melotte; Emmanuelle Viré; Elise Langenkamp; Grietje Molema; François Fuks; James G Herman; Wim van Criekinge; Arjan W Griffioen; Manon van Engeland
Identification of epigenetically silenced genes in tumor endothelial cells.
Cancer research 2007;67(9):4138-48.
2007: Ramon Martinez; Gabriele Schackert; Ricardo Yaya Tur; Iñigo Rojas-Marcos; James G Herman; Manel Esteller
Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme.
Journal of neuro-oncology 2007;83(1):91-3.
2007: Elisabeth Iljas Heath; Marcia Canto; Steven Piantadosi; Elizabeth Montgomery; Wilfred M Weinstein; James G Herman; Andrew J Dannenberg; Yang Vincent; Albert O Shar; Ernest T Hawk; Arlene A Forastiere
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial.
Journal of the National Cancer Institute 2007;99(7):545-57.
2007: Edgar Jost; N do O; Edgar Dahl; C E Maintz; P Jousten; L Habets; Stefan Wilop; James G Herman; Rainhardt Osieka; Oliver Galm
Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders.
Leukemia 2007;21(3):505-10.
2007: J M A Pijnenborg; Geeske C Dam de Veen; N Kisters; Bert Delvoux; Manon van Engeland; James G Herman; Patrick G Groothuis
RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(3):491-7.
2007: Joyce E Ohm; Kelly M McGarvey; Xiaobing Yu; Linzhao Cheng; Kornel E Schuebel; Leslie Cope; Helai P Mohammad; Wei Chen; Vincent C Daniel; Wayne Yu; berman david; Thomas Jenuwein; Kevin Pruitt; Saul J Sharkis; DAVID WATKINS; James G Herman; Stephen B Baylin
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Nature genetics 2007;39(2):237-42.
2007: Hetty Carraway; James G Herman
Monitoring methylation and gene expression in cancer.
Methods in molecular biology (Clifton, N.J.) 2007;383():187-202.
2007: Malcolm V Brock; James G Herman; Stephen B Baylin
Cancer as a manifestation of aberrant chromatin structure.
Cancer journal (Sudbury, Mass.) 2007;13(1):3-8.
2007: Rebekah L Zinn; Kevin Pruitt; Sayaka Eguchi; Stephen B Baylin; James G Herman
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site.
Cancer research 2007;67(1):194-201.
2006: Linda C Chu; Charles G Eberhart; Stuart A Grossman; James G Herman
Epigenetic silencing of multiple genes in primary CNS lymphoma.
International journal of cancer. Journal international du cancer 2006;119(10):2487-91.
2006: Mingzhou Guo; Michael G House; Yoshimitsu Akiyama; Yu Qi; Domenico Capagna; John W Harmon; Stephen B Baylin; Malcolm V Brock; James G Herman
Hypermethylation of the GATA gene family in esophageal cancer.
International journal of cancer. Journal international du cancer 2006;119(9):2078-83.
2006: Sharon Benzeno; F Lu; Mingzhou Guo; Olena Barbash; Fang Zhang; James G Herman; Peter S Klein; Anil K Rustgi; J Alan Diehl
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.
Oncogene 2006;25(47):6291-303.
2006: Anju Singh; Vikas Misra; Rajesh K Thimmulappa; Hannah Lee; Stephen Ames; Mohammad Hoque; James G Herman; Stephen B Baylin; David Sidransky; Edward Gabrielson; Malcolm V Brock; Shyam Biswal
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
PLoS medicine 2006;3(10):e420.
2006: Malcolm V Brock; Craig M Hooker; Eric A Engels; Richard D Moore; Maura L Gillison; Anthony J Alberg; Jeanne C Keruly; Stephen C Yang; Richard F Heitmiller; Stephen B Baylin; James G Herman; Julie R Brahmer
Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care.
Journal of acquired immune deficiency syndromes (1999) 2006;43(1):47-55.
2006: Lisa Gallicchio; Genevieve M Matanoski; XU GUANG TAO; Liwei Chen; Tram K Lam; Kristina Boyd; Karen Robinson; Lyssa Balick; Stephanie Mickelson; Laura E Caulfield; James G Herman; Eliseo Guallar; Anthony J Alberg
Adulthood consumption of preserved and nonpreserved vegetables and the risk of nasopharyngeal carcinoma: a systematic review.
International journal of cancer. Journal international du cancer 2006;119(5):1125-35.
2006: Mingzhou Guo; Jingli Ren; Michael G House; Yu Qi; Malcolm V Brock; James G Herman
Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4515-22.
2006: Weiguo Han; Stephane Cauchi; James G Herman; Simon Spivack
DNA methylation mapping by tag-modified bisulfite genomic sequencing.
Analytical biochemistry 2006;355(1):50-61.
2006: Johann C Brandes; James G Herman
p53 expression after treatment with zebularine is not due to demethylation.
Cancer research 2006;66(13):6892; author reply 6893.
2006: Steven D Gore; Stephen B Baylin; Elizabeth Sugar; Hetty Carraway; Carole B Miller; Michael A Carducci; Michael R Grever; Oliver Galm; Tianna Dauses; Judith E Karp; MICHELLE RUDEK-RENAUT; Ming Zhao; B Douglas Smith; Jasper Manning; Anchalee Jiemjit; George J Dover; Abbie Mays; James Zwiebel; Anthony J Murgo; Li-Jun Weng; James G Herman
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.
Cancer research 2006;66(12):6361-9.
2006: Emi Ota Machida; Malcolm V Brock; Craig M Hooker; Jun Nakayama; Akiko Ishida; Jun Amano; Maria A Picchi; Steven A Belinsky; James G Herman; Shun'ichiro Taniguchi; Stephen B Baylin
Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.
Cancer research 2006;66(12):6210-8.
2006: Hubert Fenton; Brian Carlile; Elizabeth Montgomery; Hetty Carraway; James G Herman; Fikret Sahin; Gloria H Su; Pedram Argani
LKB1 protein expression in human breast cancer.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2006;14(2):146-53.
2006: Steven A Belinsky; Kieu C Liechty; Frederick D Gentry; Holly J Wolf; Justin Rogers; Kieu O Vu; Jerry Haney; Timothy C Kennedy; Fred R Hirsch; York E Miller; Wilbur A Franklin; James G Herman; Stephen B Baylin; Paul A Bunn; Tim E Byers
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.
Cancer research 2006;66(6):3338-44.
2006: Kevin Pruitt; Rebekah L Zinn; Joyce E Ohm; Kelly M McGarvey; Sung-Hae L Kang; DAVID WATKINS; James G Herman; Stephen B Baylin
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
PLoS genetics 2006;2(3):e40.
2006: Kyle D Weaver; Stuart A Grossman; James G Herman
Methylated tumor-specific DNA as a plasma biomarker in patients with glioma.
Cancer investigation 2006;24(1):35-40.
2006: Mingzhou Guo; Shuang Liu; James G Herman; Hui Zhuang; Fengmin Lu
Gefitinib-sensitizing mutation in esophageal carcinoma cell line Kyse450.
Cancer biology & therapy 2006;5(2):152-5.
2006: Sarah Derks; Cindy Postma; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Mario A J A Hermsen; Walter Giaretti; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Promoter methylation precedes chromosomal alterations in colorectal cancer development.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2006;28(5-6):247-57.
2006: Oliver Galm; James G Herman; Stephen B Baylin
The fundamental role of epigenetics in hematopoietic malignancies.
Blood reviews 2006;20(1):1-13.
2005: Oliver Galm; Stefan Wilop; Christian Lüders; Edgar Jost; Gerald Gehbauer; James G Herman; Rainhardt Osieka
Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia.
Annals of hematology 2005;84 Suppl 1():39-46.
2005: Malcolm V Brock; Craig M Hooker; Rex C-W Yung; Mingzhou Guo; Yu Han; Stephen E Ames; David C Chang; Stephen C Yang; David Mason; Marc S Sussman; Stephen B Baylin; James G Herman
Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?
The Annals of thoracic surgery 2005;80(4):1241-7.
2005: Angela H Ting; Kornel E Schuebel; James G Herman; Stephen B Baylin
Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation.
Nature genetics 2005;37(8):906-10.
2005: Oliver Galm; Hiromu Suzuki; Yoshimitsu Akiyama; Manel Esteller; Malcolm V Brock; Rainhardt Osieka; Stephen B Baylin; James G Herman
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.
Oncogene 2005;24(30):4799-805.
2005: Johann C Brandes; Manon van Engeland; Kim A D Wouters; Matty P Weijenberg; James G Herman
CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype.
Carcinogenesis 2005;26(6):1152-6.
2005: Kyeong-Man Hong; Sei-Hoon Yang; Mingzhou Guo; James G Herman; Jin Jen
Semiautomatic detection of DNA methylation at CpG islands.
BioTechniques 2005;38(3):354, 356, 358.
2005: Bin Yang; Michael G House; Mingzhou Guo; James G Herman; Douglas P Clark
Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(3):412-20.
2005: James G Herman
Epigenetic changes in cancer and preneoplasia.
Cold Spring Harbor symposia on quantitative biology 2005;70():329-33.
2005: Oliver Galm; James G Herman
Methylation-specific polymerase chain reaction.
Methods in molecular medicine 2005;113():279-91.
2005: Malcolm V Brock; Craig M Hooker; James E Syphard; William H Westra; Li Xu; Anthony J Alberg; David Mason; Stephen B Baylin; James G Herman; Rex C-W Yung; Julie R Brahmer; Charles Rudin; David S Ettinger; Stephen C Yang
Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come.
The Journal of thoracic and cardiovascular surgery 2005;129(1):64-72.
2004: Judith C Keen; Elizabeth Garrett-Mayer; Catherine Pettit; Kelly M Mack; Jasper Manning; James G Herman; Nancy E Davidson
Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells.
Cancer biology & therapy 2004;3(12):1304-12.
2004: Mingzhou Guo; Yoshimitsu Akiyama; Michael G House; Craig M Hooker; Elisabeth Iljas Heath; Edward Gabrielson; Stephen C Yang; Yu Han; Stephen B Baylin; James G Herman; Malcolm V Brock
Hypermethylation of the GATA genes in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7917-24.
2004: Oliver Galm; Stefan Wilop; J Reichelt; Edgar Jost; Gerald Gehbauer; James G Herman; Rainhardt Osieka
DNA methylation changes in multiple myeloma.
Leukemia 2004;18(10):1687-92.
2004: Young Kyung Bae; Amy Brown; Elizabeth Garrett-Mayer; Daniel Bornman; Mary Jo Fackler; Saraswati Sukumar; James G Herman; Edward Gabrielson
Hypermethylation in histologically distinct classes of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):5998-6005.
2004: Inmaculada Ibanez de Caceres; Cristina Battagli; Manel Esteller; James G Herman; Essel Dulaimi; Mitchell I Edelson; Cynthia Bergman; Hormoz Ehya; Burton L Eisenberg; Paul Cairns
Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients.
Cancer research 2004;64(18):6476-81.
2004: Mingzhou Guo; Michael G House; Craig M Hooker; Yu Han; Elisabeth Iljas Heath; Edward Gabrielson; Stephen C Yang; Stephen B Baylin; James G Herman; Malcolm V Brock
Promoter hypermethylation of resected bronchial margins: a field defect of changes?
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5131-6.
2004: Jill Gilbert; Steven D Gore; James G Herman; Michael A Carducci
The clinical application of targeting cancer through histone acetylation and hypomethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(14):4589-96.
2004: James G Herman
Circulating methylated DNA.
Annals of the New York Academy of Sciences 2004;1022():33-9.
2004: James G Herman
Epigenetics in lung cancer: focus on progression and early lesions.
Chest 2004;125(5 Suppl):119S-22S.
2004: Hiromu Suzuki; DAVID WATKINS; Kam-Wing Jair; Kornel E Schuebel; Sanford D Markowitz; Wei Dong Chen; Theresa P Pretlow; Bin Yang; Yoshimitsu Akiyama; Manon van Engeland; Minoru Toyota; Takashi Tokino; Yuji Hinoda; Kohzoh Imai; James G Herman; Stephen B Baylin
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Nature genetics 2004;36(4):417-22.
2004: Eva Musulén; Victor Moreno; German Reyes; Francesc Josep Sancho; Miguel A Peinado; Manel Esteller; James G Herman; Neus Combalia; Mercè Rey; Gabriel Capellá
Standardized approach for microsatellite instability detection in gastric carcinomas.
Human pathology 2004;35(3):335-42.
2004: Donna Douglas; Yoshimitsu Akiyama; Hetty Carraway; Steven A Belinsky; Manel Esteller; Edward Gabrielson; Sigmund Weitzman; Trevor Williams; James G Herman; Stephen B Baylin
Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer.
Cancer research 2004;64(5):1611-20.
2004: Manel Esteller; James G Herman
Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.
Oncogene 2004;23(1):1-8.
2004: Sarah Derks; Marjolein H F M Lentjes; Debby M E I Hellebrekers; Adriaan P de Bruïne; James G Herman; Manon van Engeland
Methylation-specific PCR unraveled.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2004;26(5-6):291-9.
2003: Michael G House; Mingzhou Guo; David T Efron; Keith D Lillemoe; John L Cameron; James E Syphard; Craig M Hooker; Susan C Abraham; Elizabeth Montgomery; James G Herman; Malcolm V Brock
Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2003;7(8):1004-14; discussion 1014.
2003: Michael G House; James G Herman; Mingzhou Guo; Craig M Hooker; Richard D Schulick; John L Cameron; Ralph Hruban; Anirban Maitra; Charles J Yeo
Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms.
Surgery 2003;134(6):902-8; discussion 909.
2003: Yoshimitsu Akiyama; Neil Watkins; Hiromu Suzuki; Kam-Wing Jair; Manon van Engeland; Manel Esteller; Hidekazu Sakai; Chun-Yan Ren; Yasuhito Yuasa; James G Herman; Stephen B Baylin
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Molecular and cellular biology 2003;23(23):8429-39.
2003: James G Herman; Stephen B Baylin
Gene silencing in cancer in association with promoter hypermethylation.
The New England journal of medicine 2003;349(21):2042-54.
2003: Steven A Belinsky; Donna M Klinge; Christine A Stidley; Jean-Pierre J Issa; James G Herman; Thomas H March; Stephen B Baylin
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Cancer research 2003;63(21):7089-93.
2003: Paul G Corn; E Robert McDonald; James G Herman; Wafik S El-Deiry
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Nature genetics 2003;35(3):229-37.
2003: Max M van Noesel; Saskia van Bezouw; Paul A Voûte; James G Herman; Rob Pieters; Rogier Versteeg
Clustering of hypermethylated genes in neuroblastoma.
Genes, chromosomes & cancer 2003;38(3):226-33.
2003: Michael G House; Ignacio I Wistuba; Pedram Argani; Mingzhou Guo; Richard D Schulick; Ralph Hruban; James G Herman; Anirban Maitra
Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer.
Annals of surgical oncology 2003;10(8):882-9.
2003: Gemma Tarafa; Esther Prat; Rosa-Ana Risques; Sara González; Jordi Camps; Mònica Grau; Elisabet Guinó; Victor Moreno; Manel Esteller; James G Herman; Josep Ramon Germà; Rosa Miró; Miguel A Peinado; Gabriel Capellá
Common genetic evolutionary pathways in familial adenomatous polyposis tumors.
Cancer research 2003;63(18):5731-7.
2003: Lan Yan; Sharyl J Nass; Dawn Smith; William G Nelson; James G Herman; Nancy E Davidson
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.
Cancer biology & therapy 2003;2(5):552-6.
2003: Michael G House; James G Herman; Mingzhou Guo; Craig M Hooker; Richard D Schulick; Keith D Lillemoe; John L Cameron; Ralph Hruban; Anirban Maitra; Charles J Yeo
Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms.
Annals of surgery 2003;238(3):423-31; discussion 431-2.
2003: Bin Yang; Mingzhou Guo; James G Herman; Douglas P Clark
Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma.
The American journal of pathology 2003;163(3):1101-7.
2003: David Sarrió; Gema Moreno-Bueno; David Hardisson; Carolina Sánchez-Estévez; Mingzhou Guo; James G Herman; Carlos Gamallo; Manel Esteller; José Palacios
Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.
International journal of cancer. Journal international du cancer 2003;106(2):208-15.
2003: Malcolm V Brock; Mingzhou Gou; Yoshimitsu Akiyama; Alison Muller; Tsung-Teh Wu; Elizabeth Montgomery; Mari Deasel; Paul Germonpré; Lewis Rubinson; Richard F Heitmiller; Stephen C Yang; Arlene A Forastiere; Stephen B Baylin; James G Herman
Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):2912-9.
2003: Manon van Engeland; Matty P Weijenberg; Guido M J M Roemen; Mirian Brink; Adriaan P de Bruïne; R Alexandra Goldbohm; Piet A van den Brandt; Stephen B Baylin; Anton F P M de Goeij; James G Herman
Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer.
Cancer research 2003;63(12):3133-7.
2003: Charles R Holst; Gerard J Nuovo; Manel Esteller; Karen L Chew; Stephen B Baylin; James G Herman; Thea D Tlsty
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Cancer research 2003;63(7):1596-601.
2003: Gema Moreno-Bueno; David Hardisson; David Sarrió; Carolina Sánchez; Raúl Cassia; Jaime Prat; James G Herman; Manel Esteller; Xavier Matías-Guiu; José Palacios
Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia.
The Journal of pathology 2003;199(4):471-8.
2003: Oliver Galm; Hirohide Yoshikawa; Manel Esteller; Rainhardt Osieka; James G Herman
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma.
Blood 2003;101(7):2784-8.
2003: Maria Fe Paz; Mario F Fraga; Sonia Avila; Mingzhou Guo; Marina Pollan; James G Herman; Manel Esteller
A systematic profile of DNA methylation in human cancer cell lines.
Cancer research 2003;63(5):1114-21.
2003: Michael G House; Mingzhou Guo; Christine A Iacobuzio-Donahue; James G Herman
Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas.
Carcinogenesis 2003;24(2):193-8.
2003: Wen Yong Chen; Xiaobei Zeng; Mark Carter; Craig N Morrell; Ray-Whay Chiu Yen; Manel Esteller; DAVID WATKINS; James G Herman; Joseph L Mankowski; Stephen B Baylin
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Nature genetics 2003;33(2):197-202.
2003: Kurtis E Bachman; Ben Ho Park; Ina Rhee; Harith Rajagopalan; James G Herman; Stephen B Baylin; Kenneth W Kinzler; Bert Vogelstein
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.
Cancer cell 2003;3(1):89-95.
2002: Jill A Fahrner; Sayaka Eguchi; James G Herman; Stephen B Baylin
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.
Cancer research 2002;62(24):7213-8.
2002: Frederic Tort; Silvia Hernàndez; Sílvia Beà; Antonio Martínez; Manel Esteller; James G Herman; Xavier Puig; Emma Camacho; Montse Sánchez; Iracema Nayach; Armando Lopez-Guillermo; Pedro L Fernández; Dolors Colomer; Luis Hernàndez; Elias Campo
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas.
Blood 2002;100(13):4602-8.
2002: James G Herman
Hypermethylation pathways to colorectal cancer. Implications for prevention and detection.
Gastroenterology clinics of North America 2002;31(4):945-58.
2002: Gema Moreno-Bueno; David Hardisson; Carolina Sánchez; David Sarrió; Raúl Cassia; Ginesa García-Rostán; Jaime Prat; Mingzhou Guo; James G Herman; Xavier Matías-Guiu; Manel Esteller; José Palacios
Abnormalities of the APC/beta-catenin pathway in endometrial cancer.
Oncogene 2002;21(52):7981-90.
2002: Enrique Lerma; Manel Esteller; James G Herman; Jaime Prat
Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus.
Human pathology 2002;33(11):1120-5.
2002: Manel Esteller; Mingzhou Guo; Victor Moreno; Miquel Angel Peinado; Gabriel Capella; Oliver Galm; Stephen B Baylin; James G Herman
Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer.
Cancer research 2002;62(20):5902-5.
2002: Elizabeth Cameron; Aleksandar Mijovic; James G Herman; Stephen B Baylin; Anjala Pradhan; Ghulam J Mufti; Feyruz V Rassool
P15INK4B is not mutated in adult familial myelodysplastic syndromes.
British journal of haematology 2002;119(1):277-9.
2002: Manel Esteller; Mario F Fraga; Maria Fe Paz; Elias Campo; Dolors Colomer; Francisco J Novo; María J Calasanz; Oliver Galm; Mingzhou Guo; Javier Benitez; James G Herman
Cancer epigenetics and methylation.
Science (New York, N.Y.) 2002;297(5588):1807-8; discussion 1807-8.
2002: Maria Fe Paz; Sonia Avila; Mario F Fraga; Marina Pollan; Gabriel Capella; Miguel A Peinado; Montserrat Sanchez-Cespedes; James G Herman; Manel Esteller
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
Cancer research 2002;62(15):4519-24.
2002: Montserrat Sanchez-Cespedes; Paola Parrella; Manel Esteller; Shuji Nomoto; Barry Trink; James M Engles; William H Westra; James G Herman; David Sidransky
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Cancer research 2002;62(13):3659-62.
2002: Hiromu Suzuki; Edward Gabrielson; Wei Chen; Ramaswamy Anbazhagan; Manon van Engeland; Matty P Weijenberg; James G Herman; Stephen B Baylin
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.
Nature genetics 2002;31(2):141-9.
2002: Manon van Engeland; Guido M J M Roemen; Mirian Brink; Marco M M Pachen; Matty P Weijenberg; Adriaan P de Bruïne; Jan-Willem Arends; Piet A van den Brandt; Anton F P M de Goeij; James G Herman
K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
Oncogene 2002;21(23):3792-5.
2002: Max M van Noesel; Saskia van Bezouw; Gajja S Salomons; Paul A Voûte; Rob Pieters; Stephen B Baylin; James G Herman; Rogier Versteeg
Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation.
Cancer research 2002;62(7):2157-61.
2002: Päivi Laiho; Virpi Launonen; Päivi Lahermo; Manel Esteller; Mingzhou Guo; James G Herman; Jukka-Pekka Mecklin; Heikki Järvinen; Pertti Sistonen; Kyoung-Mee Kim; Darryl Shibata; richard Houlston; Lauri A Aaltonen
Low-level microsatellite instability in most colorectal carcinomas.
Cancer research 2002;62(4):1166-70.
2002: Manel Esteller; Gianluca Gaidano; Steven Goodman; Vittorina Zagonel; Daniela Capello; Barbara Botto; Davide Rossi; Annunziata Gloghini; Umberto Vitolo; Antonino Carbone; Stephen B Baylin; James G Herman
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Journal of the National Cancer Institute 2002;94(1):26-32.
2002: Oliver Galm; Michael R Rountree; Kurtis E Bachman; Kam-Wing Jair; Stephen B Baylin; James G Herman
Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density.
Genome research 2002;12(1):153-7.
2002: Manel Esteller; James G Herman
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours.
The Journal of pathology 2002;196(1):1-7.
2001: Manel Esteller; Mario F Fraga; Mingzhou Guo; J Garcia-Foncillas; I Hedenfalk; A K Godwin; J Trojan; Catherine Vaurs-Barrière; Yves-Jean Bignon; S Ramus; J Benitez; T Caldes; Y Akiyama; Y Yuasa; Virpi Launonen; M J Canal; R Rodriguez; Gabriel Capella; Miguel A Peinado; A Borg; L A Aaltonen; bruce ponder; Stephen B Baylin; James G Herman
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
Human molecular genetics 2001;10(26):3001-7.
2001: Xiaoming Yang; D L Phillips; AT Ferguson; William G Nelson; James G Herman; Nancy E Davidson
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Cancer research 2001;61(19):7025-9.
2001: Otavia L Caballero; D Cohen; Q Liu; Manel Esteller; JT Bonacum; P White; James M Engles; Robert Yochem; James G Herman; William H Westra; Christoph Lengauer; David Sidransky; Jin Jen
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer.
Genes, chromosomes & cancer 2001;32(2):119-25.
2001: Paul G Corn; Elisabeth Iljas Heath; Richard F Heitmiller; Franz Fogt; Arlene A Forastiere; James G Herman; Tsung-Teh Wu
Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2765-9.
2001: Paul Cairns; Manel Esteller; James G Herman; Mark P Schoenberg; Carmen Jeronimo; Montserrat Sanchez-Cespedes; N H Chow; M Grasso; LI WU; William H Westra; David Sidransky
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2727-30.
2001: Daniel M Bornman; S Mathew; J Alsruhe; James G Herman; Edward Gabrielson
Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals.
The American journal of pathology 2001;159(3):831-5.
2001: S A Nicholson; N T Okby; Mohammed A Khan; Judith A Welsh; Mary McMenamin; William D Travis; James R Jett; Henry D Tazelaar; Victor Trastek; Peter C Pairolero; P G Corn; James G Herman; Lance A Liotta; Neil E Caporaso; Curtis C Harris
Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma.
Cancer research 2001;61(14):5636-43.
2001: Arvind K Virmani; Asha Rathi; Ubaradka G Sathyanarayana; Asha Padar; Chun Xian Huang; H T Cunnigham; Alfredo J Farinas; Sara Milchgrub; David M Euhus; Michael Z Gilcrease; James G Herman; John D Minna; Adi F Gazdar
Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1998-2004.
2001: Manel Esteller; Rosa-Ana Risques; M Toyota; Gabriel Capella; Victor Moreno; Miguel A Peinado; Stephen B Baylin; James G Herman
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Cancer research 2001;61(12):4689-92.
2001: Michael R Rountree; Kurtis E Bachman; James G Herman; Stephen B Baylin
DNA methylation, chromatin inheritance, and cancer.
Oncogene 2001;20(24):3156-65.
2001: Stephen B Baylin; James G Herman
Promoter hypermethylation--can this change alone ever designate true tumor suppressor gene function?
Journal of the National Cancer Institute 2001;93(9):664-5.
2001: James G Herman; Stephen B Baylin
Methylation-specific PCR.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 10():Unit 10.6.
2001: H Yoshikawa; K Matsubara; G S Qian; P Jackson; John Groopman; J E Manning; C C Harris; James G Herman
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.
Nature genetics 2001;28(1):29-35.
2001: Manel Esteller; P G Corn; Stephen B Baylin; James G Herman
A gene hypermethylation profile of human cancer.
Cancer research 2001;61(8):3225-9.
2001: Manel Esteller; C Cordon-Cardo; P G Corn; Meltzer Stephen J.; K S Pohar; DAVID WATKINS; Gabriel Capella; Miguel A Peinado; X Matias-Guiu; J Prat; Stephen B Baylin; James G Herman
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.
Cancer research 2001;61(7):2816-21.
2001: Stephen B Baylin; Manel Esteller; Michael R Rountree; Kurtis E Bachman; Kornel E Schuebel; James G Herman
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.
Human molecular genetics 2001;10(7):687-92.
2001: Montserrat Sanchez-Cespedes; PA Decker; Kara Doffek; M Esteller; William H Westra; E A Alawi; James G Herman; Micheal J Demeure; David Sidransky; Steven A Ahrendt
Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers.
Cancer research 2001;61(5):2092-6.
2001: A Steven Fleisher; M Esteller; Gen Tamura; A Rashid; O Colin Stine; Jing Yin; Tongtong Zou; John M Abraham; Dehe Kong; Satoshi Nishizuka; Stephen P James; Keith T Wilson; James G Herman; Meltzer Stephen J.
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.
Oncogene 2001;20(3):329-35.
2001: Manel Esteller; S González; Rosa-Ana Risques; Eugenio Marcuello; Bafalluy Mangues; Josep Ramon Germà; James G Herman; Gabriel Capellà; Miguel A Peinado
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(2):299-304.
2001: Maria Soengas; P Capodieci; D Polsky; J Mora; M Esteller; X Opitz-Araya; R McCombie; James G Herman; W L Gerald; Yuri Lazebnik; C Cordón-Cardó; Scott W Lowe
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma.
Nature 2001;409(6817):207-11.
2001: Ramaswamy Anbazhagan; James G Herman; K Enika; Edward Gabrielson
Spreadsheet-based program for the analysis of DNA methylation.
BioTechniques 2001;30(1):110-4.
2000: X Yang; AT Ferguson; Sharyl J Nass; D L Phillips; KA Butash; S M Wang; James G Herman; Nancy E Davidson
Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition.
Cancer research 2000;60(24):6890-4.
2000: M Esteller; Jesus Garcia-Foncillas; Esther Andion; Steven Goodman; O F Hidalgo; V Vanaclocha; Stephen B Baylin; James G Herman
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
The New England journal of medicine 2000;343(19):1350-4.
2000: P G Corn; B Douglas Smith; E S Ruckdeschel; D Douglas; Stephen B Baylin; James G Herman
E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4243-8.
2000: William A Palmisano; Kevin K Divine; G Saccomanno; Frank D Gilliland; Stephen B Baylin; James G Herman; Steven A Belinsky
Predicting lung cancer by detecting aberrant promoter methylation in sputum.
Cancer research 2000;60(21):5954-8.
2000: Stephen B Baylin; S A Belinsky; James G Herman
Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.
Journal of the National Cancer Institute 2000;92(18):1460-1.
2000: A Steven Fleisher; M Esteller; Noam Harpaz; Anatoly Leytin; A Rashid; Yan Xu; J Liang; O Colin Stine; Jing Yin; Tongtong Zou; John M Abraham; Dehe Kong; Keith T Wilson; Stephen P James; James G Herman; Meltzer Stephen J.
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.
Cancer research 2000;60(17):4864-8.
2000: Manel Esteller; A Sparks; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; S Gonzalez; Gemma Tarafa; David Sidransky; Meltzer Stephen J.; Stephen B Baylin; James G Herman
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Cancer research 2000;60(16):4366-71.
2000: Sharyl J Nass; James G Herman; Edward Gabrielson; Philip W Iversen; F F Parl; Nancy E Davidson; Jeremy R Graff
Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.
Cancer research 2000;60(16):4346-8.
2000: Manel Esteller; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; DAVID WATKINS; Jean-Pierre J Issa; David Sidransky; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer research 2000;60(9):2368-71.
2000: Ina Rhee; Kam-Wing Jair; Ray-Whay Chiu Yen; Christoph Lengauer; James G Herman; Kenneth W Kinzler; Bert Vogelstein; Stephen B Baylin; Kornel E Schuebel
CpG methylation is maintained in human cancer cells lacking DNMT1.
Nature 2000;404(6781):1003-7.
2000: M Esteller; J M Silva; G Dominguez; F Bonilla; Xavier Matias-Guiu; E Lerma; Elena Bussaglia; Jaime Prat; IC Harkes; E A Repasky; Edward Gabrielson; Mieke Schutte; Stephen B Baylin; James G Herman
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
Journal of the National Cancer Institute 2000;92(7):564-9.
2000: Stephen B Baylin; James G Herman
DNA hypermethylation in tumorigenesis: epigenetics joins genetics.
Trends in genetics : TIG 2000;16(4):168-74.
2000: Montserrat Sanchez-Cespedes; Manel Esteller; LI WU; Homaira Nawroz-Danish; George H Yoo; Wayne M Koch; Jin Jen; James G Herman; David Sidransky
Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.
Cancer research 2000;60(4):892-5.
2000: C Eng; James G Herman; Stephen B Baylin
A bird's eye view of global methylation.
Nature genetics 2000;24(2):101-2.
2000: Jeremy R Graff; Edward Gabrielson; H Fujii; Stephen B Baylin; James G Herman
Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.
The Journal of biological chemistry 2000;275(4):2727-32.
2000: Manel Esteller; E Avizienyte; P G Corn; Ragnhild A Lothe; Stephen B Baylin; Lauri A Aaltonen; James G Herman
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.
Oncogene 2000;19(1):164-8.
2000: James G Herman; Stephen B Baylin
Promoter-region hypermethylation and gene silencing in human cancer.
Current topics in microbiology and immunology 2000;249():35-54.
2000: M Esteller; Silvia Tortola; Minoru Toyota; G Capella; Miguel A Peinado; Stephen B Baylin; James G Herman
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
Cancer research 2000;60(1):129-33.
1999: M Esteller; Lluis Catasus; Xavier Matias-Guiu; G L Mutter; Jaime Prat; Stephen B Baylin; James G Herman
hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis.
The American journal of pathology 1999;155(5):1767-72.
1999: G J Nuovo; T W Plaia; S A Belinsky; Stephen B Baylin; James G Herman
In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12754-9.
1999: Montserrat Sanchez-Cespedes; AL Reed; MR Buta; LI WU; William H Westra; James G Herman; Stephen C Yang; Jin Jen; David Sidransky
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer.
Oncogene 1999;18(43):5843-9.
1999: James G Herman
Hypermethylation of tumor suppressor genes in cancer.
Seminars in cancer biology 1999;9(5):359-67.
1999: E E Cameron; Stephen B Baylin; James G Herman
p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing.
Blood 1999;94(7):2445-51.
1999: Montserrat Sanchez-Cespedes; Manel Esteller; K Hibi; F O Cope; William H Westra; Steven Piantadosi; James G Herman; Jin Jen; David Sidransky
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2450-4.
1999: Jay-Jiguang Zhu; T Maruyama; L B Jacoby; James G Herman; James Gusella; Peter Black; J K Wu
Clonal analysis of a case of multiple meningiomas using multiple molecular genetic approaches: pathology case report.
Neurosurgery 1999;45(2):409-16.
1999: Minoru Toyota; NITA AHUJA; M Ohe-Toyota; James G Herman; Stephen B Baylin; Jean-Pierre J Issa
CpG island methylator phenotype in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8681-6.
1999: P G Corn; Steven J Kuerbitz; M M van Noesel; M Esteller; Nicole Compitello; Stephen B Baylin; James G Herman
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.
Cancer research 1999;59(14):3352-6.
1999: R A Katzenellenbogen; Stephen B Baylin; James G Herman
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Blood 1999;93(12):4347-53.
1999: A Steven Fleisher; M Esteller; Suna Wang; Gen Tamura; H Suzuki; Jing Yin; Tongtong Zou; John M Abraham; Dehe Kong; Kara N Smolinski; YQ Shi; MG Rhyu; SM Powell; Stephen P James; Keith T Wilson; James G Herman; Meltzer Stephen J.
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.
Cancer research 1999;59(5):1090-5.
1999: Steven A Ahrendt; JT Chow; L H Xu; Stephen C Yang; Claus F Eisenberger; M Esteller; James G Herman; LI WU; PA Decker; Jin Jen; David Sidransky
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.
Journal of the National Cancer Institute 1999;91(4):332-9.
1999: Kurtis E Bachman; James G Herman; P G Corn; A Merlo; Joseph F Costello; W K Cavenee; Stephen B Baylin; Jeremy R Graff
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Cancer research 1999;59(4):798-802.
1999: Manel Esteller; Stanley R Hamilton; Peter C Burger; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
Cancer research 1999;59(4):793-7.
1999: James G Herman
p16(INK4): involvement early and often in gastrointestinal malignancies.
Gastroenterology 1999;116(2):483-5.
1999: E E Cameron; Kurtis E Bachman; S Myöhänen; James G Herman; Stephen B Baylin
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer.
Nature genetics 1999;21(1):103-7.
1999: Manel Esteller; Montserrat Sanchez-Cespedes; R Rosell; David Sidransky; Stephen B Baylin; James G Herman
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.
Cancer research 1999;59(1):67-70.
1998: David F Jarrard; H Kinoshita; Y Shi; C Sandefur; D Hoff; Lorraine F Meisner; C Chang; James G Herman; William B Isaacs; N Nassif
Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells.
Cancer research 1998;58(23):5310-4.
1998: Manel Esteller; Ross Levine; Stephen B Baylin; L H Ellenson; James G Herman
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.
Oncogene 1998;17(18):2413-7.
1998: Manel Esteller; P G Corn; J M Urena; Edward Gabrielson; Stephen B Baylin; James G Herman
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.
Cancer research 1998;58(20):4515-8.
1998: Steven A Belinsky; Kristen J Nikula; William A Palmisano; R Michels; G Saccomanno; Edward Gabrielson; Stephen B Baylin; James G Herman
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11891-6.
1998: Paul Cairns; Ella Evron; Kenji Okami; N Halachmi; Manel Esteller; James G Herman; S Bose; SI Wang; Ramon Parsons; David Sidransky
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Oncogene 1998;16(24):3215-8.
1998: Rena Lapidus; Sharyl J Nass; KA Butash; F F Parl; Sigmund A Weitzman; J G Graff; James G Herman; Nancy E Davidson
Mapping of ER gene CpG island methylation-specific polymerase chain reaction.
Cancer research 1998;58(12):2515-9.
1998: James G Herman; A Umar; Kornelia Polyak; Jeremy R Graff; NITA AHUJA; Jean-Pierre J Issa; Sanford Markowitz; James Willson; Stanley R Hamilton; Kenneth W Kinzler; Michael F Kane; Richard D Kolodner; Bert Vogelstein; T A Kunkel; Stephen B Baylin
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6870-5.
1998: Jeremy R Graff; V E Greenberg; James G Herman; William H Westra; ER Boghaert; Kenneth B Ain; Motoyasu Saji; Martha A Zeiger; Stephen G Zimmer; Stephen B Baylin
Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.
Cancer research 1998;58(10):2063-6.
1998: S Hiraguri; T Godfrey; H Nakamura; J Graff; Colin Collins; L Shayesteh; N Doggett; K Johnson; M Wheelock; James G Herman; Stephen B Baylin; Daniel Pinkel; Joe Gray
Mechanisms of inactivation of E-cadherin in breast cancer cell lines.
Cancer research 1998;58(9):1972-7.
1998: S K Myöhänen; Stephen B Baylin; James G Herman
Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.
Cancer research 1998;58(4):591-3.
1998: Peter Muscarella; W Scott Melvin; William E Fisher; J Foor; E Christopher Ellison; James G Herman; WJ Schirmer; Charles L Hitchcock; Barry R DeYoung; Christopher M Weghorst
Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation.
Cancer research 1998;58(2):237-40.
1998: Stephen B Baylin; James G Herman; Jeremy R Graff; Paula M Vertino; Jean-Pierre J Issa
Alterations in DNA methylation: a fundamental aspect of neoplasia.
Advances in cancer research 1998;72():141-96.
1997: Paul Cairns; Kenji Okami; Sarel Halachmi; N Halachmi; Manel Esteller; James G Herman; Jin Jen; William B Isaacs; G Steven Bova; David Sidransky
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
Cancer research 1997;57(22):4997-5000.
1997: Jeremy R Graff; James G Herman; S Myöhänen; Stephen B Baylin; Paula M Vertino
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.
The Journal of biological chemistry 1997;272(35):22322-9.
1997: NITA AHUJA; A L Mohan; Qing Li; J M Stolker; James G Herman; Stanley R Hamilton; Stephen B Baylin; Jean-Pierre J Issa
Association between CpG island methylation and microsatellite instability in colorectal cancer.
Cancer research 1997;57(16):3370-4.
1997: Mieke Schutte; Ralph Hruban; Joseph Geradts; R Maynard; Werner Hilgers; S K Rabindran; Christopher A Moskaluk; Stephan Hahn; Irmgard Schwarte-Waldhoff; Wolff Schmiegel; Stephen B Baylin; Scott E Kern; James G Herman
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
Cancer research 1997;57(15):3126-30.
1997: David F Jarrard; G Steven Bova; Charles M Ewing; Sokhom Pin; SH Nguyen; Stephen B Baylin; Paul Cairns; David Sidransky; James G Herman; William B Isaacs
Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer.
Genes, chromosomes & cancer 1997;19(2):90-6.
1997: T Kubota; S Das; S L Christian; Stephen B Baylin; James G Herman; David Ledbetter
Methylation-specific PCR simplifies imprinting analysis.
Nature genetics 1997;16(1):16-7.
1997: Jean-Pierre J Issa; Stephen B Baylin; James G Herman
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
Leukemia 1997;11 Suppl 1():S7-11.
1997: James G Herman; Curt I Civin; Jean-Pierre J Issa; Michael I Collector; Saul J Sharkis; Stephen B Baylin
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.
Cancer research 1997;57(5):837-41.
1997: DS Swafford; S K Middleton; William A Palmisano; Kristen J Nikula; Yohannes Tesfaigzi; Stephen B Baylin; James G Herman; Steven A Belinsky
Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
Molecular and cellular biology 1997;17(3):1366-74.
1996: James G Herman; Jeremy R Graff; S Myöhänen; Barry D Nelkin; Stephen B Baylin
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9821-6.
1996: James G Herman; Jin Jen; A Merlo; Stephen B Baylin
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
Cancer research 1996;56(4):722-7.
1996: J Wu; James G Herman; G Wilson; R Y Lee; Ray-Whay Chiu Yen; M Mabry; A de Bustros; Barry D Nelkin; Stephen B Baylin
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Cancer research 1996;56(3):616-22.
1995: Jeremy R Graff; James G Herman; Rena Lapidus; H Chopra; R Xu; David F Jarrard; William B Isaacs; PAULA PITHA-ROWE; Nancy E Davidson; Stephen B Baylin
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.
Cancer research 1995;55(22):5195-9.
1995: James G Herman; A Merlo; Li Mao; Rena Lapidus; Jean-Pierre J Issa; Nancy E Davidson; David Sidransky; Stephen B Baylin
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.
Cancer research 1995;55(20):4525-30.
1995: A Merlo; James G Herman; Li Mao; Daniel Lee; Edward Gabrielson; Peter C Burger; Stephen B Baylin; David Sidransky
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Nature medicine 1995;1(7):686-92.
1994: James G Herman; F Latif; Y Weng; M I Lerman; B Zbar; S Liu; D Samid; D S Duan; JR Gnarra; W M Linehan
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9700-4.
1993: J Wu; Jean-Pierre J Issa; James G Herman; D E Bassett; Barry D Nelkin; Stephen B Baylin
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8891-5.
1989: Barry D Nelkin; Y Nakamura; R W White; A C de Bustros; James G Herman; S A Wells; Stephen B Baylin
Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma.
Cancer research 1989;49(15):4114-9.
1988: James G Herman; W E Beschorner; Kenneth L Baughman; J K Boitnott; Georgia B Vogelsang; WM BAUMGARTNER
Pseudo-graft-versus-host disease in heart and heart-lung recipients.
Transplantation 1988;46(1):93-8.
1987: James G Herman
Keeping a hold of hard copy.
Applied radiology 1987;16(1):21, 24, 26.