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Emmanuel Hermans

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Ronald Deumens; Patrice Forget; Emmanuel Hermans; Patricia Lavand'homme; Michael Schubert; Arnaud Steyaert; Marc De Kock
Prevention of chronic postoperative pain: Cellular, molecular, and clinical insights for mechanism-based treatment approaches.
Stéphanie De Simoni; Emmanuel Hermans; Bernard Knoops; Dominique Linard; Julie Goemaere
Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP(+) -induced cell death.
M C Focant; Stéphanie Goursaud; C Boucherie; A O Dumont; Emmanuel Hermans
PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats.

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All Publications

2013: Ronald Deumens; Patrice Forget; Emmanuel Hermans; Patricia Lavand'homme; Michael Schubert; Arnaud Steyaert; Marc De Kock
Prevention of chronic postoperative pain: Cellular, molecular, and clinical insights for mechanism-based treatment approaches.
Progress in neurobiology 2013;104():1-37.
2013: Stéphanie De Simoni; Emmanuel Hermans; Bernard Knoops; Dominique Linard; Julie Goemaere
Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP(+) -induced cell death.
Journal of neurochemistry 2013;125(3):473-85.
2013: M C Focant; Stéphanie Goursaud; C Boucherie; A O Dumont; Emmanuel Hermans
PICK1 expression in reactive astrocytes within the spinal cord of amyotrophic lateral sclerosis (ALS) rats.
Neuropathology and applied neurobiology 2013;39(3):231-42.
2012: Barbara Bosier; Didier M Lambert; Birgit Mertens; Yvette Michotte; Giulio G Muccioli; Sophie Sarre; Emmanuel Hermans
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Neuropharmacology 2012;62(7):2328-36.
2012: Beryl Koener; Jean-Marie Maloteaux; Barbara Bosier; Marylène C Focant; Emmanuel Hermans
Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole.
Progress in neuro-psychopharmacology & biological psychiatry 2012;36(1):60-70.
2011: Stéphanie Goursaud; Julie V Berger; Marylène C Focant; Jean-Marie Maloteaux; Yannick Nizet; Emmanuel Hermans
The VPAC2 agonist peptide histidine isoleucine (PHI) up-regulates glutamate transport in the corpus callosum of a rat model of amyotrophic lateral sclerosis (hSOD1G93A) by inhibiting caspase-3 mediated inactivation of GLT-1a.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3674-86.
2011: Marylène C Focant; Stéphanie Goursaud; Yannick Nizet; Emmanuel Hermans
Differential regulation of C-terminal splice variants of the glutamate transporter GLT-1 by tumor necrosis factor-alpha in primary cultures of astrocytes.
Neurochemistry international 2011;58(7):751-8.
2011: Beryl Koener; Emmanuel Hermans
Inducible expression of G protein-coupled receptors in transfected cells.
Methods in molecular biology (Clifton, N.J.) 2011;746():3-20.
2011: Beryl Koener; Stéphanie Goursaud; Morgane Van De Stadt; André-Guilhem Calas; Anne P Jeanjean; Jean-Marie Maloteaux; Emmanuel Hermans
Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization.
Naunyn-Schmiedeberg's archives of pharmacology 2011;383(1):65-77.
2010: Barbara Bosier; Sophie Sarre; Ilse Smolders; Yvette Michotte; Emmanuel Hermans; Didier M Lambert
Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.
Neuropharmacology 2010;59(6):503-10.
2010: Barbara Bosier; Giulio G Muccioli; Emmanuel Hermans; Didier M Lambert
Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities.
Biochemical pharmacology 2010;80(1):1-12.
2009: Sébastien Tilleux; Stéphanie Goursaud; Emmanuel Hermans
Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia.
Neurochemistry international 2009;55(1-3):35-40.
2009: Stéphanie Goursaud; Jean-Marie Maloteaux; Emmanuel Hermans
Distinct expression and regulation of the glutamate transporter isoforms GLT-1a and GLT-1b in cultured astrocytes from a rat model of amyotrophic lateral sclerosis (hSOD1G93A).
Neurochemistry international 2009;55(1-3):28-34.
2009: Nicolas Vanhoutte; Jorge Abarca-Quinones; Bénédicte F Jordan; Bernard Gallez; Jean-Marie Maloteaux; Emmanuel Hermans
Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat.
Experimental neurology 2009;218(1):56-63.
2009: Cédric Boucherie; Sabrina Schäfer; Patricia Lavand'homme; Jean-Marie Maloteaux; Emmanuel Hermans
Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis.
Journal of neuroscience research 2009;87(9):2034-46.
2009: Cédric Boucherie; Emmanuel Hermans
Adult stem cell therapies for neurological disorders: benefits beyond neuronal replacement?
Journal of neuroscience research 2009;87(7):1509-21.
2009: Stéphanie Goursaud; Elena N Kozlova; Jean-Marie Maloteaux; Emmanuel Hermans
Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties.
Journal of neurochemistry 2009;108(6):1442-52.
2009: Emmanuel Hermans
Multiplicity and regulation of G-protein couplings.
Bulletin et mémoires de l'Académie royale de médecine de Belgique 2009;164(5-6):255-62.
2008: Barbara Bosier; Didier M Lambert; Emmanuel Hermans
Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.
FEBS letters 2008;582(28):3861-7.
2008: Barbara Bosier; Emmanuel Hermans; Dm Lambert
Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor.
British journal of pharmacology 2008;155(1):24-33.
2008: Cédric Boucherie; Anne-Sophie Caumont; Jean-Marie Maloteaux; Emmanuel Hermans
In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1(G93A)).
Experimental neurology 2008;212(2):557-61.
2008: Nicolas Vanhoutte; Emmanuel Hermans
Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1.
FEBS letters 2008;582(13):1847-52.
2008: Sébastien Tilleux; Emmanuel Hermans
Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures.
Journal of neurochemistry 2008;105(6):2224-36.
2008: Stéphanie Goursaud; Jean-Marie Maloteaux; Emmanuel Hermans
Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake.
Journal of neurochemistry 2008;105(4):1165-75.
2007: Beryl Koener; Emmanuel Hermans; Hermans Emmanuel; Jean-Marie Maloteaux; Anne Jean-Jean; Eric Louis Constant
Paradoxical motor syndrome following a switch from atypical neuroleptics to aripiprazole.
The American journal of psychiatry 2007;164(9):1437-8.
2007: Sébastien Tilleux; Julie Berger; Emmanuel Hermans
Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5.
Journal of neuroimmunology 2007;189(1-2):23-30.
2007: Barbara Bosier; Sébastien Tilleux; Mustapha Najimi; Didier M Lambert; Emmanuel Hermans
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
Journal of neurochemistry 2007;102(6):1996-2007.
2007: Barbara Bosier; Emmanuel Hermans
Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance.
Trends in pharmacological sciences 2007;28(8):438-46.
2007: Sébastien Tilleux; Emmanuel Hermans
Neuroinflammation and regulation of glial glutamate uptake in neurological disorders.
Journal of neuroscience research 2007;85(10):2059-70.
2006: Isabelle de Hemptinne; Cédric Boucherie; Roland Pochet; Kadiombo Bantubungi; Serge N Schiffmann; Jean-Marie Maloteaux; Emmanuel Hermans
Unilateral induction of progenitors in the spinal cord of hSOD1(G93A) transgenic rats correlates with an asymmetrical hind limb paralysis.
Neuroscience letters 2006;401(1-2):25-9.
2006: Anne-Sophie Caumont; Jean-Noël Octave; Emmanuel Hermans
Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells.
Journal of neurochemistry 2006;97(1):128-39.
2006: Anne-Sophie Caumont; Jean-Noël Octave; Emmanuel Hermans
Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells.
Neuroscience letters 2006;394(3):196-201.
2006: Céline Vermeiren; Isabelle Hemptinne; Nicolas Vanhoutte; Sébastien Tilleux; Jean-Marie Maloteaux; Emmanuel Hermans
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2006;96(3):719-31.
2005: Céline Vermeiren; Mustapha Najimi; Nicolas Vanhoutte; Sébastien Tilleux; Isabelle de Hemptinne; Jean-Marie Maloteaux; Emmanuel Hermans
Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes.
Journal of neurochemistry 2005;94(2):405-16.
2005: Mustapha Najimi; Jean-Marie Maloteaux; Emmanuel Hermans
Pertussis toxin-sensitive modulation of glutamate transport by endothelin-1 type A receptors in glioma cells.
Biochimica et biophysica acta 2005;1668(2):195-202.
2005: Céline Vermeiren; Mustapha Najimi; Jean-Marie Maloteaux; Emmanuel Hermans
Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation.
Neurochemistry international 2005;46(2):137-47.
2004: Nicolas Vanhoutte; Isabelle de Hemptinne; Céline Vermeiren; Jean-Marie Maloteaux; Emmanuel Hermans
In vitro differentiated neural stem cells express functional glial glutamate transporters.
Neuroscience letters 2004;370(2-3):230-5.
2004: Sophie J Govaerts; Emmanuel Hermans; Didier M Lambert
Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(3):233-43.
2004: V Race; Sandrine Marie; Pascal Kienlen-Campard; Emmanuel Hermans; Jean-Noël Octave; Georges Van den Berghe; Marie-Françoise Vincent
Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1227-9.
2004: Isabelle de Hemptinne; Céline Vermeiren; Jean-Marie Maloteaux; Emmanuel Hermans
Induction of glial glutamate transporters in adult mesenchymal stem cells.
Journal of neurochemistry 2004;91(1):155-66.
2004: Sophie J Govaerts; Giulio G Muccioli; Emmanuel Hermans; Didier M Lambert
Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors.
European journal of pharmacology 2004;495(1):43-53.
2004: Magali Peeters; Pascal Romieu; Tangui Maurice; Tsung-Ping Su; Jean-Marie Maloteaux; Emmanuel Hermans
Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine.
The European journal of neuroscience 2004;19(8):2212-20.
2003: Muriel Geurts; Jean-Marie Maloteaux; Emmanuel Hermans
Altered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletion.
Biochemical pharmacology 2003;66(7):1163-70.
2003: Delphine Skrzydelski; Anne-Marie Lhiaubet; Antony Lebeau; Patricia Forgez; Misa Yamada; Emmanuel Hermans; William Rostene; Didier Pelaprat
Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.
Molecular pharmacology 2003;64(2):421-9.
2003: Emmanuel Hermans
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors.
Pharmacology & therapeutics 2003;99(1):25-44.
2003: Magali Peeters; Jean-Marie Maloteaux; Emmanuel Hermans
Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum.
Neuroscience letters 2003;343(3):205-9.
2002: Muriel Geurts; Emmanuel Hermans; Jean-Marie Maloteaux
Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum.
Neuroscience letters 2002;333(2):146-50.
2002: Magali Peeters; Guylène Page; Jean-Marie Maloteaux; Emmanuel Hermans
Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine.
Brain research 2002;949(1-2):32-41.
2002: Mustapha Najimi; Jean-Marie Maloteaux; Emmanuel Hermans
Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1.
FEBS letters 2002;523(1-3):224-8.
2002: Mustapha Najimi; Philippe Gailly; Jean-Marie Maloteaux; Emmanuel Hermans
Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins.
FEBS letters 2002;512(1-3):329-33.
2002: Guylène Page; Sylvie Chalon; Patrick Emond; Jean-Marie Maloteaux; Emmanuel Hermans
Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells.
Neurochemistry international 2002;40(2):105-13.
2001: Mustapha Najimi; Emmanuel Hermans; William Rostène; Patricia Forgez
Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells.
Metabolic brain disease 2001;16(3-4):165-74.
2001: Guylène Page; Magali Peeters; Mustapha Najimi; Jean-Marie Maloteaux; Emmanuel Hermans
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Journal of neurochemistry 2001;76(5):1282-90.
2000: Philippe Gailly; Mustapha Najimi; Emmanuel Hermans
Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins.
FEBS letters 2000;483(2-3):109-13.
2000: Guylène Page; Magali Peeters; Jean-Marie Maloteaux; Emmanuel Hermans
Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine.
European journal of pharmacology 2000;403(1-2):75-80.
1999: Muriel Geurts; Emmanuel Hermans; Jean-Marie Maloteaux
Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment.
European journal of pharmacology 1999;382(2):119-27.
1999: Didier M Lambert; F G DiPaolo; P Sonveaux; Martial Kanyonyo; Sophie J Govaerts; Emmanuel Hermans; Jean-Luc Bueb; Nathalie M Delzenne; Eric Tschirhart
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors.
Biochimica et biophysica acta 1999;1440(2-3):266-74.
1999: Muriel Geurts; Emmanuel Hermans; J Cumps; Jean-Marie Maloteaux
Dopamine receptor-modulated [35S]GTPgammaS binding in striatum of 6-hydroxydopamine-lesioned rats.
Brain research 1999;841(1-2):135-42.
1999: Martial Kanyonyo; Sophie J Govaerts; Emmanuel Hermans; Jacques H Poupaert; Didier M Lambert
3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.
Bioorganic & medicinal chemistry letters 1999;9(15):2233-6.
1999: Muriel Geurts; Emmanuel Hermans; Jean-Marie Maloteaux
Assessment of striatal D1 and D2 dopamine receptor-G protein coupling by agonist-induced [35S]GTP gamma S binding.
Life sciences 1999;65(16):1633-45.
1998: Mustapha Najimi; Frédérique Souazé; M Méndez; Emmanuel Hermans; Tsouria Berbar; William Rostène; Patricia Forgez
Activation of receptor gene transcription is required to maintain cell sensitization after agonist exposure. Study on neurotensin receptor.
The Journal of biological chemistry 1998;273(34):21634-41.
1998: Emmanuel Hermans; Jean-Marie Maloteaux
Mechanisms of regulation of neurotensin receptors.
Pharmacology & therapeutics 1998;79(2):89-104.
1997: Emmanuel Hermans; Muriel Geurts; Jean-Marie Maloteaux
Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor.
British journal of pharmacology 1997;121(8):1817-23.
1997: Emmanuel Hermans; M A Vanisberg; Muriel Geurts; Jean-Marie Maloteaux
Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons.
Neurochemistry international 1997;31(2):291-9.
1996: Emmanuel Hermans; Jean-Marie Maloteaux
Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells.
Biochemical pharmacology 1996;51(12):1749-52.
1996: P Gailly; Emmanuel Hermans; Jean-Marie Gillis
Role of [Ca2+]i in "Ca2+ stores depletion-Ca2+ entry coupling' in fibroblasts expressing the rat neurotensin receptor.
The Journal of physiology 1996;491 ( Pt 3)():635-46.
1996: Emmanuel Hermans; Jean-Noël Octave; Jean-Marie Maloteaux
Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization.
Molecular pharmacology 1996;49(2):365-72.
1995: Emmanuel Hermans; P Gailly; Jean-Marie Gillis; Jean-Noël Octave; Jean-Marie Maloteaux
Lack of rapid desensitization of Ca2+ responses in transfected CHO cells expressing the rat neurotensin receptor despite agonist-induced internalization.
Journal of neurochemistry 1995;64(6):2518-25.
1994: Emmanuel Hermans; P Gailly; Jean-Noël Octave; Jean-Marie Maloteaux
Rapid desensitization of agonist-induced calcium mobilization in transfected PC12 cells expressing the rat neurotensin receptor.
Biochemical and biophysical research communications 1994;198(1):400-7.
1994: Emmanuel Hermans; Jean-Noël Octave; Jean-Marie Maloteaux
Receptor mediated internalization of neurotensin in transfected Chinese hamster ovary cells.
Biochemical pharmacology 1994;47(1):89-91.
1994: Jean-Marie Maloteaux; Emmanuel Hermans
Agonist-induced muscarinic cholinergic receptor internalization, recycling and degradation in cultured neuronal cells. Cellular mechanisms and role in desensitization.
Biochemical pharmacology 1994;47(1):77-88.
1993: P Gailly; Emmanuel Hermans; Jean-Noël Octave; Jean-Marie Gillis
Specific increase of genetic expression of parvalbumin in fast skeletal muscles of mdx mice.
FEBS letters 1993;326(1-3):272-4.
1993: Emmanuel Hermans; A P Jeanjean; P M Laduron; Jean-Noël Octave; Jean-Marie Maloteaux
Postnatal ontogeny of the rat brain neurotensin receptor mRNA.
Neuroscience letters 1993;157(1):45-8.
1993: Emmanuel Hermans; A P Jeanjean; V Fardin; Laurent Pradier; C Garret; P M Laduron; Jean-Noël Octave; Jean-Marie Maloteaux
Interaction of the substance P receptor antagonist RP 67580 with the rat brain NK1 receptor expressed in transfected CHO cells.
European journal of pharmacology 1993;245(1):43-50.
1992: Saliha Moussaoui; Emmanuel Hermans; A M Mathieu; Bruno Bonici; F Clerc; F Guinet; C Garret; P M Laduron
Polyclonal antibodies against the rat NK1 receptor: characterization and localization in the spinal cord.
Neuroreport 1992;3(12):1073-6.
1992: Emmanuel Hermans; Jean-Marie Maloteaux; Jean-Noël Octave
Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor.
Brain research. Molecular brain research 1992;15(3-4):332-8.