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Valerie Askanas

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Carla D'Agostino; W King Engel; Anna Nogalska; Mafalda Cacciottolo; Valerie Askanas
Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis.
Anna Nogalska; Carla D'Agostino; W King Engel; Valerie Askanas
Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers.
C D'Agostino; Anna Nogalska; W King Engel; Valerie Askanas
In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.

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2011: Carla D'Agostino; W King Engel; Anna Nogalska; Mafalda Cacciottolo; Valerie Askanas
Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis.
Acta neuropathologica 2011;122(5):627-36.
2011: Anna Nogalska; Carla D'Agostino; W King Engel; Valerie Askanas
Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers.
Neuroscience letters 2011;503(3):229-33.
2011: C D'Agostino; Anna Nogalska; W King Engel; Valerie Askanas
In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.
Neuropathology and applied neurobiology 2011;37(3):315-20.
2010: Anna Nogalska; Carla D'Agostino; W King Engel; William L Klein; Valerie Askanas
Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers.
Acta neuropathologica 2010;120(5):661-6.
2010: Anna Nogalska; Carla D'Agostino; Chiara Terracciano; W King Engel; Valerie Askanas
Impaired autophagy in sporadic inclusion-body myositis and in endoplasmic reticulum stress-provoked cultured human muscle fibers.
The American journal of pathology 2010;177(3):1377-87.
2010: Anna Nogalska; Carla D'Agostino; W King Engel; Kelvin J A Davies; Valerie Askanas
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.
Neurobiology of aging 2010;31(9):1637-48.
2010: Anna Nogalska; W King Engel; Valerie Askanas
Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers--possibly caused by endoplasmic reticulum stress.
Neuroscience letters 2010;474(3):140-3.
2010: Chiara Terracciano; Anna Nogalska; W King Engel; Valerie Askanas
In AbetaPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AbetaPP751 and GSK3beta activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis.
Journal of neurochemistry 2010;112(2):389-96.
2009: Anna Nogalska; Chiara Terracciano; Carla D'Agostino; W King Engel; Valerie Askanas
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Acta neuropathologica 2009;118(3):407-13.
2009: Valerie Askanas; W King Engel; Anna Nogalska
Inclusion body myositis: a degenerative muscle disease associated with intra-muscle fiber multi-protein aggregates, proteasome inhibition, endoplasmic reticulum stress and decreased lysosomal degradation.
Brain pathology (Zurich, Switzerland) 2009;19(3):493-506.
2009: Gaetano Vattemi; Anna Nogalska; W King Engel; Carla D'Agostino; Frederic Checler; Valerie Askanas
Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis.
Acta neuropathologica 2009;117(5):569-74.
2008: Valerie Askanas; W King Engel
Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains.
Acta neuropathologica 2008;116(6):583-95.
2008: Chiara Terracciano; Anna Nogalska; W King Engel; Slawomir Wojcik; Valerie Askanas
In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized.
Free radical biology & medicine 2008;45(6):773-9.
2008: S Wójcik; Anna Nogalska; W King Engel; Valerie Askanas
Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy.
Folia morphologica 2008;67(1):6-12.
2007: Valerie Askanas; Slawomir Wojcik; W King Engel
Expression of Nogo-A in human muscle fibers is not specific for amyotrophic lateral sclerosis.
Annals of neurology 2007;62(6):676-7; author reply 677.
2007: Valerie Askanas; W King Engel
Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis.
Current opinion in rheumatology 2007;19(6):550-9.
2007: Slawomir Wojcik; W King Engel; Riqiang Yan; Janis McFerrin; Valerie Askanas
NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers.
Acta neuropathologica 2007;114(5):517-26.
2007: Slawomir Wojcik; Anna Nogalska; Janis McFerrin; W King Engel; Gabriela Olędzka; Valerie Askanas
Myostatin precursor protein is increased and associates with amyloid-beta precursor protein in inclusion-body myositis culture model.
Neuropathology and applied neurobiology 2007;33(2):238-42.
2007: Anna Nogalska; Slawomir Wojcik; W King Engel; Janis McFerrin; Valerie Askanas
Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis.
Experimental neurology 2007;204(2):610-8.
2006: Slawomir Wojcik; W King Engel; Valerie Askanas
Increased expression of Noga-A in ALS muscle biopsies is not unique for this disease.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases 2006;25(3):116-8.
2006: Slawomir Wojcik; W King Engel; Janis McFerrin; Orlando Paciello; Valerie Askanas
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis.
Neuromuscular disorders : NMD 2006;16(12):839-44.
2006: Orlando Paciello; S Wójcik; W King Engel; Janis McFerrin; Valerie Askanas
Parkin and its association with alpha-synuclein and AbetaPP in inclusion-body myositis and AbetaPP-overexpressing cultured human muscle fibers.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases 2006;25(1):13-22.
2006: Anna Nogalska; W King Engel; Janis McFerrin; Koichi Kokame; Hiroto Komano; Valerie Askanas
Homocysteine-induced endoplasmic reticulum protein (Herp) is up-regulated in sporadic inclusion-body myositis and in endoplasmic reticulum stress-induced cultured human muscle fibers.
Journal of neurochemistry 2006;96(5):1491-9.
2006: Valerie Askanas; W King Engel
Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition.
Neurology 2006;66(2 Suppl 1):S39-48.
2006: W King Engel; Valerie Askanas
Inclusion-body myositis: clinical, diagnostic, and pathologic aspects.
Neurology 2006;66(2 Suppl 1):S20-9.
2005: Pietro Fratta; W King Engel; Janis McFerrin; Kelvin J A Davies; Sharon W Lin; Valerie Askanas
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers.
The American journal of pathology 2005;167(2):517-26.
2005: Sławomir Wójcik; W King Engel; Janis McFerrin; Valerie Askanas
Myostatin is increased and complexes with amyloid-beta within sporadic inclusion-body myositis muscle fibers.
Acta neuropathologica 2005;110(2):173-7.
2005: Valerie Askanas; W King Engel
Sporadic inclusion-body myositis: a proposed key pathogenetic role of the abnormalities of the ubiquitin-proteasome system, and protein misfolding and aggregation.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases 2005;24(1):17-24.
2005: Valerie Askanas; W King Engel
Molecular pathology and pathogenesis of inclusion-body myositis.
Microscopy research and technique 2005;67(3-4):114-20.
2004: P Fratta; W King Engel; Fijs W B van Leeuwen; Elly M Hol; Gaetano Vattemi; Valerie Askanas
Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.
Neurology 2004;63(6):1114-7.
2004: Valerie Askanas; W King Engel
Unicorns, dragons, polymyositis, and other mythical beasts.
Neurology 2004;63(2):403-4; author reply 404.
2004: Gaetano Vattemi; W King Engel; Janis McFerrin; Valerie Askanas
Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.
The American journal of pathology 2004;164(1):1-7.
2003: Valerie Askanas; W King Engel
Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging.
Current opinion in rheumatology 2003;15(6):737-44.
2003: Valerie Askanas; W King Engel; Janis McFerrin; Gaetano Vattemi
Transthyretin Val122Ile, accumulated Abeta, and inclusion-body myositis aspects in cultured muscle.
Neurology 2003;61(2):257-60.
2003: Gaetano Vattemi; W King Engel; Janis McFerrin; Valerie Askanas
Cystatin C colocalizes with amyloid-beta and coimmunoprecipitates with amyloid-beta precursor protein in sporadic inclusion-body myositis muscles.
Journal of neurochemistry 2003;85(6):1539-46.
2003: Valerie Askanas; W King Engel
Unfolding story of inclusion-body myositis and myopathies: role of misfolded proteins, amyloid-beta, cholesterol, and aging.
Journal of child neurology 2003;18(3):185-90.
2003: Gaetano Vattemi; W King Engel; Janis McFerrin; Lucia Pastorino; Joseph Buxbaum; Valerie Askanas
BACE1 and BACE2 in pathologic and normal human muscle.
Experimental neurology 2003;179(2):150-8.
2002: Valerie Askanas; W King Engel
Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms.
Current opinion in neurology 2002;15(5):525-31.
2002: Valerie Askanas; W King Engel
Newest pathogenetic considerations in inclusion-body myositis: possible role of amyloid-beta, cholesterol, relation to aging and to Alzheimer's disease.
Current rheumatology reports 2002;4(5):427-33.
2002: M Jaworska-Wilczynska; GM Wilczynski; W King Engel; Dudley K Strickland; Karl H Weisgraber; Valerie Askanas
Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle.
Neurology 2002;58(3):438-45.
2001: Gaetano Vattemi; W King Engel; Janis McFerrin; Joseph Buxbaum; Lucia Pastorino; Valerie Askanas
Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis.
Lancet 2001;358(9297):1962-4.
2001: GM Wilczynski; W King Engel; Valerie Askanas
Novel cytoplasmic immunolocalization of RNA polymerase II in inclusion-body myositis muscle.
Neuroreport 2001;12(9):1809-14.
2001: Y Wang; Yuichi Michikawa; C Mallidis; Y Bai; Linda Woodhouse; K E Yarasheski; C A Miller; Valerie Askanas; W King Engel; S Bhasin; Giuseppe Attardi
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4022-7.
2001: Valerie Askanas; W King Engel
Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(1):1-14.
2000: CC Kok; A Boyt; S Gaudieri; Ralph N Martins; Valerie Askanas; M Dalakas; L Kiers; Frank L Mastaglia; Michael J Garlepp
Mitochondrial DNA variants in inclusion body myositis.
Neuromuscular disorders : NMD 2000;10(8):604-11.
2000: GM Wilczynski; W King Engel; Valerie Askanas
Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation.
Neuroscience letters 2000;293(1):33-6.
2000: Valerie Askanas; W King Engel; RB Alvarez; Janis McFerrin; A Broccolini
Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions.
Journal of neuropathology and experimental neurology 2000;59(7):592-8.
2000: A Broccolini; W King Engel; RB Alvarez; Valerie Askanas
Redox factor-1 in muscle biopsies of patients with inclusion-body myositis.
Neuroscience letters 2000;287(1):1-4.
2000: GM Wilczynski; W King Engel; Valerie Askanas
Association of active extracellular signal-regulated protein kinase with paired helical filaments of inclusion-body myositis muscle suggests its role in inclusion-body myositis tau phosphorylation.
The American journal of pathology 2000;156(6):1835-40.
2000: Valerie Askanas; W King Engel; RB Alvarez; Blas Frangione; Jorge Ghiso; Ruben Vidal
Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele.
Annals of neurology 2000;47(4):544-9.
2000: A Broccolini; W King Engel; RB Alvarez; Valerie Askanas
Paired helical filaments of inclusion-body myositis muscle contain RNA and survival motor neuron protein.
The American journal of pathology 2000;156(4):1151-5.
1999: Janis McFerrin; W King Engel; Valerie Askanas
Cultured inclusion-body myositis muscle fibers do not accumulate beta-amyloid precursor protein and can be innervated.
Neurology 1999;53(9):2184-7.
1999: A Broccolini; W King Engel; Valerie Askanas
Localization of survival motor neuron protein in human apoptotic-like and regenerating muscle fibers, and neuromuscular junctions.
Neuroreport 1999;10(8):1637-41.
1998: Valerie Askanas; W King Engel
Does overexpression of betaAPP in aging muscle have a pathogenic role and a relevance to Alzheimer's disease? Clues from inclusion body myositis, cultured human muscle, and transgenic mice.
The American journal of pathology 1998;153(6):1673-7.
1998: Valerie Askanas; W King Engel
Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: current concepts of diagnosis and pathogenesis.
Current opinion in rheumatology 1998;10(6):530-42.
1998: Janis McFerrin; W King Engel; Valerie Askanas
Impaired innervation of cultured human muscle overexpressing betaAPP experimentally and genetically: relevance to inclusion-body myopathies.
Neuroreport 1998;9(14):3201-5.
1998: CC Yang; Valerie Askanas; W King Engel; RB Alvarez
Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions.
Neuroscience letters 1998;254(2):77-80.
1998: Valerie Askanas; W King Engel
Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: diseases of oxidative stress and aging?
Archives of neurology 1998;55(7):915-20.
1998: CC Yang; RB Alvarez; W King Engel; S L Heller; Valerie Askanas
Nitric oxide-induced oxidative stress in autosomal recessive and dominant inclusion-body myopathies.
Brain : a journal of neurology 1998;121 ( Pt 6)():1089-97.
1998: Valerie Askanas; W King Engel; RB Alvarez
Fourteen newly recognized proteins at the human neuromuscular junctions--and their nonjunctional accumulation in inclusion-body myositis.
Annals of the New York Academy of Sciences 1998;841():28-56.
1998: Valerie Askanas; W King Engel; CC Yang; RB Alvarez; Virginia M-Y Lee; Thomas Wisniewski
Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.
The American journal of pathology 1998;152(4):889-95.
1998: Valerie Askanas; W King Engel
Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging.
Scandinavian journal of rheumatology 1998;27(6):389-405.
1997: CC Yang; RB Alvarez; W King Engel; C K Haun; Valerie Askanas
Immunolocalization of nitric oxide synthases at the postsynaptic domain of human and rat neuromuscular junctions--light and electron microscopic studies.
Experimental neurology 1997;148(1):34-44.
1997: Valerie Askanas; Janis McFerrin; RB Alvarez; S Baqué; W King Engel
Beta APP gene transfer into cultured human muscle induces inclusion-body myositis aspects.
Neuroreport 1997;8(9-10):2155-8.
1997: Valerie Askanas
New developments in hereditary inclusion body myopathies.
Annals of neurology 1997;41(4):421-2.
1996: CC Yang; RB Alvarez; W King Engel; Valerie Askanas
Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis.
Neuroreport 1996;8(1):153-8.
1996: M Mirabella; RB Alvarez; W King Engel; Karl H Weisgraber; Valerie Askanas
Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies.
Annals of neurology 1996;40(6):864-72.
1996: Valerie Askanas; W King Engel; M Mirabella; Karl H Weisgraber; Ann M Saunders; Allen D Roses; Janis McFerrin
Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy.
Annals of neurology 1996;40(2):264-5.
1996: M Mirabella; RB Alvarez; M Bilak; W King Engel; Valerie Askanas
Difference in expression of phosphorylated tau epitopes between sporadic inclusion-body myositis and hereditary inclusion-body myopathies.
Journal of neuropathology and experimental neurology 1996;55(7):774-86.
1996: Valerie Askanas; RB Alvarez; M Mirabella; W King Engel
Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.
Annals of neurology 1996;39(3):389-91.
1996: Valerie Askanas; Janis McFerrin; S Baqué; RB Alvarez; E Sarkozi; W King Engel
Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1314-9.
1995: Valerie Askanas; W King Engel
New advances in the understanding of sporadic inclusion-body myositis and hereditary inclusion-body myopathies.
Current opinion in rheumatology 1995;7(6):486-96.
1995: Robert C Griggs; Valerie Askanas; S DiMauro; A Engel; G Karpati; Jerry R Mendell; L P Rowland
Inclusion body myositis and myopathies.
Annals of neurology 1995;38(5):705-13.
1995: S Braun; E Sarkozi; Janis McFerrin; Valerie Askanas
Hydrocortisone influences voltage-dependent L-type calcium channels in cultured human skeletal muscle.
Journal of neuroscience research 1995;41(6):727-33.
1995: Valerie Askanas; E Sarkozi; M Bilak; RB Alvarez; W King Engel
Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs.
Neuroreport 1995;6(7):1045-9.
1995: Valerie Askanas
Neurotrophic factors and amyotrophic lateral sclerosis.
Advances in neurology 1995;68():241-4.
1994: E Sarkozi; Valerie Askanas; W King Engel
Abnormal accumulation of prion protein mRNA in muscle fibers of patients with sporadic inclusion-body myositis and hereditary inclusion-body myopathy.
The American journal of pathology 1994;145(6):1280-4.
1994: Valerie Askanas; W King Engel; M Mirabella
Idiopathic inflammatory myopathies: inclusion-body myositis, polymyositis, and dermatomyositis.
Current opinion in neurology 1994;7(5):448-56.
1994: E Sarkozi; Valerie Askanas; S A Johnson; Janis McFerrin; W King Engel
Expression of beta-amyloid precursor protein gene is developmentally regulated in human muscle fibers in vivo and in vitro.
Experimental neurology 1994;128(1):27-33.
1994: M Bilak; Valerie Askanas; W King Engel
Alpha 1-antichymotrypsin is strongly immunolocalized at normal human and rat neuromuscular junctions.
Synapse (New York, N.Y.) 1994;16(4):280-3.
1994: Valerie Askanas; M Mirabella; W King Engel; RB Alvarez; Karl H Weisgraber
Apolipoprotein E immunoreactive deposits in inclusion-body muscle diseases.
Lancet 1994;343(8893):364-5.
1994: Valerie Askanas; W King Engel; M Bilak; RB Alvarez; Dennis J Selkoe
Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.
The American journal of pathology 1994;144(1):177-87.
1993: Mark A Sussman; M Bilak; Larry Kedes; W King Engel; Valerie Askanas
Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions.
Experimental cell research 1993;209(2):388-91.
1993: Valerie Askanas; W King Engel
New advances in inclusion-body myositis.
Current opinion in rheumatology 1993;5(6):732-41.
1993: Valerie Askanas; M Bilak; W King Engel; RB Alvarez; F Tomé; A Leclerc
Prion protein is abnormally accumulated in inclusion-body myositis.
Neuroreport 1993;5(1):25-8.
1993: A Martinuzzi; Lodovica Vergani; R Carrozzo; Marina Fanin; L Bartoloni; Corrado Angelini; Valerie Askanas; W King Engel
Expression of muscle-type phosphorylase in innervated and aneural cultured muscle of patients with myophosphorylase deficiency.
The Journal of clinical investigation 1993;92(4):1774-80.
1993: Valerie Askanas; RB Alvarez; W King Engel
beta-Amyloid precursor epitopes in muscle fibers of inclusion body myositis.
Annals of neurology 1993;34(4):551-60.
1993: Valerie Askanas; M Bilak; W King Engel; A Leclerc; F Tomé
Prion protein is strongly immunolocalized at the postsynaptic domain of human normal neuromuscular junctions.
Neuroscience letters 1993;159(1-2):111-4.
1993: E Sarkozi; Valerie Askanas; S A Johnson; W King Engel; RB Alvarez
beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle.
Neuroreport 1993;4(6):815-8.
1993: C Mariotti; Valerie Askanas; W King Engel
New organotypic model to culture the entire fetal rat spinal cord.
Journal of neuroscience methods 1993;48(1-2):157-67.
1993: Valerie Askanas; W King Engel; RB Alvarez
Enhanced detection of congo-red-positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique.
Neurology 1993;43(6):1265-7.
1993: S Braun; Valerie Askanas; W King Engel; E N Ibrahim
Long-term treatment with glucocorticoids increases synthesis and stability of junctional acetylcholine receptors on innervated cultured human muscle.
Journal of neurochemistry 1993;60(5):1929-35.
1993: M Bilak; Valerie Askanas; W King Engel
Strong immunoreactivity of alpha 1-antichymotrypsin co-localizes with beta-amyloid protein and ubiquitin in vacuolated muscle fibers of inclusion-body myositis.
Acta neuropathologica 1993;85(4):378-82.
1992: Valerie Askanas; W King Engel; RB Alvarez
Strong immunoreactivity of beta-amyloid precursor protein, including the beta-amyloid protein sequence, at human neuromuscular junctions.
Neuroscience letters 1992;143(1-2):96-100.
1992: Valerie Askanas; W King Engel; RB Alvarez
Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis.
The American journal of pathology 1992;141(1):31-6.
1992: P Serdaroglu; Valerie Askanas; W King Engel
Immunocytochemical localization of ubiquitin at human neuromuscular junctions.
Neuropathology and applied neurobiology 1992;18(3):232-6.
1992: Y C Park-Matsumoto; Valerie Askanas; W King Engel
The influence of muscle contractile activity versus neural factors on morphologic properties of innervated cultured human muscle.
Journal of neurocytology 1992;21(5):329-40.
1992: Valerie Askanas; Janis McFerrin; Y C Park-Matsumoto; C S Lee; W King Engel
Glucocorticoid increases acetylcholinesterase and organization of the postsynaptic membrane in innervated cultured human muscle.
Experimental neurology 1992;115(3):368-75.
1992: Valerie Askanas; W King Engel; R B Alvarez; G G Glenner
beta-Amyloid protein immunoreactivity in muscle of patients with inclusion-body myositis.
Lancet 1992;339(8792):560-1.
1992: Valerie Askanas; P Serdaroglu; W King Engel; RB Alvarez
Immunocytochemical localization of ubiquitin in inclusion body myositis allows its light-microscopic distinction from polymyositis.
Neurology 1992;42(2):460-1.
1992: S Braun; Valerie Askanas; W King Engel
Different degradation rates of junctional and extrajunctional acetylcholine receptors of human muscle cultured in monolayer and innervated by fetal rat spinal cord neurons.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1992;10(1):37-44.
1992: Valerie Askanas; RB Alvarez
Fast and reliable new method for electron-microscopic identification of cytoplasmic tubulo-filaments in muscle biopsies of patients with inclusion-body myositis.
Acta neuropathologica 1992;84(3):335-6.
1991: Valerie Askanas; P Serdaroglu; W King Engel; RB Alvarez
Immunolocalization of ubiquitin in muscle biopsies of patients with inclusion body myositis and oculopharyngeal muscular dystrophy.
Neuroscience letters 1991;130(1):73-6.
1991: Valerie Askanas; C Mariotti; W King Engel
Trophic factors for cultured lower motor neurons.
Advances in neurology 1991;56():37-56.
1990: T Kobayashi; Valerie Askanas; K Saito; W King Engel; K Ishikawa
Abnormalities of aneural and innervated cultured muscle fibers from patients with myotonic atrophy (dystrophy).
Archives of neurology 1990;47(8):893-6.
1990: Valerie Askanas; A Bornemann; W King Engel
Immunocytochemical localization of desmin at human neuromuscular junctions.
Neurology 1990;40(6):949-53.
1990: G Pegolo; Valerie Askanas; W King Engel
Expression of muscle-specific isozymes of phosphorylase and creatine kinase in human muscle fibers cultured aneurally in serum-free, hormonally/chemically enriched medium.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1990;8(3):299-308.
1990: A Martinuzzi; Valerie Askanas; W King Engel
Paralysis of innervated cultured human muscle fibers affects enzymes differentially.
Journal of neurochemistry 1990;54(1):223-9.
1989: F M Tomé; Valerie Askanas; W King Engel; R B Alvarez; C S Lee
Nuclear inclusions in innervated cultured muscle fibers from patients with oculopharyngeal muscular dystrophy.
Neurology 1989;39(7):926-32.
1989: Valerie Askanas; W King Engel; K Eagleson; G Micaglio
Influence of TRH and TRH analogues RGH-2202 and DN-1417 on cultured ventral spinal cord neurons.
Annals of the New York Academy of Sciences 1989;553():325-36.
1988: A Martinuzzi; Valerie Askanas; T Kobayashi; W King Engel
Asynchronous regulation of muscle specific isozymes of creatine kinase, glycogen phosphorylase, lactic dehydrogenase and phosphoglycerate mutase in innervated and non-innervated cultured human muscle.
Neuroscience letters 1988;89(2):216-22.
1988: C Desnuelle; Valerie Askanas; W King Engel
Dihydropyridine-sensitive Ca2+ channel in aneurally cultured human muscles. Relationship between high-affinity binding site and inhibition of calcium uptake.
FEBS letters 1988;230(1-2):95-100.
1988: G Micaglio; Valerie Askanas; F Moriwaka; W King Engel
Age-dependent requirements of cultured spinal cord neurons.
Developmental neuroscience 1988;10(1):12-6.
1988: Giuseppe Vita; Valerie Askanas; A Martinuzzi; W King Engel
Histoenzymatic profile of human muscle cultured in monolayer and innervated de novo by fetal rat spinal cord.
Muscle & nerve 1988;11(1):1-9.
1987: T Kobayashi; Valerie Askanas; W King Engel
Human muscle cultured in monolayer and cocultured with fetal rat spinal cord: importance of dorsal root ganglia for achieving successful functional innervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(10):3131-41.
1987: C Desnuelle; Valerie Askanas; W King Engel
Insulin enhances development of functional voltage-dependent Ca2+ channels in aneurally cultured human muscle.
Journal of neurochemistry 1987;49(4):1133-8.
1987: K M Rösler; Valerie Askanas; W King Engel; A Martinuzzi
Effects of electrical stimulation and tetrodotoxin paralysis on expression of muscle-specific isozymes of four enzymes in aneurally cultured embryonic rat muscle.
Experimental neurology 1987;97(3):739-45.
1987: Valerie Askanas; A Martinuzzi; W King Engel; T Kobayashi; L Z Stern; J D Hsu
Accumulation of CK-MM is impaired in innervated and contracting cultured muscle fibers of Duchenne muscular dystrophy patients.
Life sciences 1987;41(8):927-33.
1987: Valerie Askanas; H Kwan; RB Alvarez; W King Engel; T Kobayashi; A Martinuzzi; E F Hawkins
De novo neuromuscular junction formation on human muscle fibres cultured in monolayer and innervated by foetal rat spinal cord: ultrastructural and ultrastructural--cytochemical studies.
Journal of neurocytology 1987;16(4):523-37.
1987: A Martinuzzi; Valerie Askanas; T Kobayashi; W King Engel; J E Gorsky
Developmental expression of the muscle-specific isozyme of phosphoglycerate mutase in human muscle cultured in monolayer and innervated by fetal rat spinal cord.
Experimental neurology 1987;96(2):365-75.
1986: A Martinuzzi; Valerie Askanas; T Kobayashi; W King Engel; S Di Mauro
Expression of muscle-gene-specific isozymes of phosphorylase and creatine kinase in innervated cultured human muscle.
The Journal of cell biology 1986;103(4):1423-9.
1985: Valerie Askanas; W King Engel; T Kobayashi
Thyrotropin-releasing hormone enhances motor neuron-evoked contractions of cultured human muscle.
Annals of neurology 1985;18(6):716-9.
1985: E F Hawkins; W King Engel; Valerie Askanas
Cells of neural crest origin as possible models to investigate thyrotropin releasing hormone action in the central nervous system.
Neuropharmacology 1985;24(11):1109-12.
1985: Valerie Askanas; S Cave; G Gallez-Hawkins; W King Engel
Fibroblast growth factor, epidermal growth factor and insulin exert a neuronal-like influence on acetylcholine receptors in aneurally cultured human muscle.
Neuroscience letters 1985;61(1-2):213-9.
1985: Valerie Askanas; G Gallez-Hawkins
Synergistic influence of polypeptide growth factors on cultured human muscle.
Archives of neurology 1985;42(8):749-52.
1985: T Kobayashi; Valerie Askanas
Acetylcholine receptors and acetylcholinesterase accumulate at the nerve-muscle contacts of de novo grown human monolayer muscle cocultured with fetal rat spinal cord.
Experimental neurology 1985;88(2):327-35.
1985: Valerie Askanas; W King Engel; H H Kwan; N B Reddy; T Husainy; J Carlo; Teepu Siddique; R J Schwartzman; C J Hanna
Autosomal dominant syndrome of lipid neuromyopathy with normal carnitine: successful treatment with long-chain fatty-acid-free diet.
Neurology 1985;35(1):66-72.
1984: A J Tahmoush; Valerie Askanas; P G Nelson; W King Engel
Adult-onset acid maltase deficiency. Electrophysiological properties of aneurally cultured muscle.
Archives of neurology 1984;41(11):1190-2.
1984: Valerie Askanas; W King Engel; H H Kwan; J V Lawrence
Abnormality of cultured muscle and Schwann's cells in familial lipid neuromyopathy. Muscle corrected by neural influence.
Archives of neurology 1984;41(9):932-4.
1984: M C Dalakas; S Fujihara; Valerie Askanas; W King Engel; G G Glenner
Nature of amyloid deposits in hypernephroma. Immunocytochemical studies in 2 cases associated with amyloid polyneuropathy.
The American journal of pathology 1984;116(3):447-54.
1984: K M Schmidt-Achert; Valerie Askanas; W King Engel
Thyrotropin-releasing hormone enhances choline acetyltransferase and creatine kinase in cultured spinal ventral horn neurons.
Journal of neurochemistry 1984;43(2):586-9.
1983: J Avigan; Valerie Askanas; W King Engel
Muscle carnitine deficiency: fatty acid metabolism in cultured fibroblasts and muscle cells.
Neurology 1983;33(8):1021-6.
1983: A J Tahmoush; Valerie Askanas; P G Nelson; W King Engel
Electrophysiologic properties of aneurally cultured muscle from patients with myotonic muscular atrophy.
Neurology 1983;33(3):311-6.
1982: M B Jackson; H Lecar; Valerie Askanas; W King Engel
Single cholinergic receptor channel currents in cultured human muscle.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(10):1465-73.
1982: N B Reddy; Valerie Askanas; W King Engel
Demonstration of 2',3'-cyclic nucleotide 3'-phosphohydrolase in cultured human Schwann cells.
Journal of neurochemistry 1982;39(3):887-9.
1982: S Schiaffino; Valerie Askanas; W King Engel; M Vitadello; S Sartore
Myosin isoenzymes in cultured human muscle.
Archives of neurology 1982;39(6):347-9.
1982: N B Reddy; Valerie Askanas; K L Oliver; J V Lawrence; L Carter; W King Engel
Biochemical and morphological effects of 20,25-diazacholesterol on cultured muscle cells.
Biochemical pharmacology 1982;31(1):91-7.
1981: L S Carter; Valerie Askanas
Vital-freezing of human muscle cultures for storage and reculture.
Muscle & nerve 1981;4(5):367-9.
1981: Valerie Askanas; P J Marangos; W King Engel
CSF from amyotrophic lateral sclerosis patients applied to motor neurons in culture fails to alter neuron-specific enolase.
Neurology 1981;31(9):1196-7.
1981: Valerie Askanas; W King Engel; V M Berginer; W F Odenwald; A Galdi
Lysosomal abnormalities in cultured schwann cells from a patient with peripheral neuropathy and continuous muscle fiber activity.
Annals of neurology 1981;10(3):238-42.
1981: M C Dalakas; W King Engel; J E McClure; A L Goldstein; Valerie Askanas
Immunocytochemical localization of thymosin-alpha 1 in thymic epithelial cells of normal and myasthenia gravis patients and in thymic cultures.
Journal of the neurological sciences 1981;50(2):239-47.
1981: M I Kaiser-Kupfer; T Kuwabara; Valerie Askanas; L Brody; K Takki; I Dvoretzky; W King Engel
Systemic manifestations of gyrate atrophy of the choroid and retina.
Ophthalmology 1981;88(4):302-6.
1981: W F Odenwald; Valerie Askanas
Ultrastructural and cytochemical characteristics of cultured rat Schwann cells.
Acta neuropathologica 1981;54(2):135-42.
1981: M C Dalakas; W King Engel; J E McClure; A L Goldstein; Valerie Askanas
Identification of human thymic epithelial cells with antibodies to thymosin alpha 1 in myasthenia gravis.
Annals of the New York Academy of Sciences 1981;377():477-85.
1980: Valerie Askanas; W King Engel; M C Dalakas; J V Lawrence; L S Carter
Human schwann cells in tissue culture: histochemical and ultrastructural studies.
Archives of neurology 1980;37(6):329-37.
1980: J McLaughlin; Valerie Askanas; W King Engel
Adrenomyeloneuropathy: increased accumulation of very long chain fatty acid in cultured skeletal muscle.
Biochemical and biophysical research communications 1980;92(4):1202-7.
1979: Valerie Askanas; W King Engel; N B Reddy; P G Barth; J Bethlem; D R Krauss; M E Hibberd; J V Lawrence; L S Carter
X-linked recessive congenital muscle fiber hypotrophy with central nuclei: abnormalities of growth and adenylate cyclase in muscle tissue cultures.
Archives of neurology 1979;36(10):604-9.
1979: Valerie Askanas; J McLaughlin; W King Engel; B T Adornato
Abnormalities in cultured muscle and peripheral nerve of a patient with adrenomyeloneuropathy.
The New England journal of medicine 1979;301(11):588-90.
1978: Valerie Askanas; W King Engel; D E Britton; B T Adornato; R M Eiben
Reincarnation in cultured muscle of mitochondrial abnormalities. Two patients with epilepsy and lactic acidosis.
Archives of neurology 1978;35(12):801-9.
1978: Valerie Askanas; W King Engel; J Bethlem
Leptomeres in cultured human muscle.
Acta neuropathologica 1978;42(3):247-50.
1977: M C Meienhofer; Valerie Askanas; D Proux-Daegelen; J C Dreyfus; W King Engel
Muscle-type phosphorylase activity present in muscle cells cultured from three patients with myophosphorylase deficiency.
Archives of neurology 1977;34(12):779-81.
1977: Valerie Askanas; W King Engel; S P Ringel; A N Bender
Acetylcholine receptors of aneurally cultured human and animal muscle.
Neurology 1977;27(11):1019-22.
1977: M A Gorycki; Valerie Askanas
Improved technique for electron microscopy of cultured cells.
Stain technology 1977;52(5):249-54.
1976: W King Engel; Valerie Askanas
Letter: Overlooked avian oncornavirus in cultured muscle--functionally significant?
Science (New York, N.Y.) 1976;192(4245):1252-3.
1976: Valerie Askanas; W King Engel; S DiMauro; B R Brooks; M Mehler
Adult-onset acid maltase deficiency. Morphologic and biochemical abnormalities reproduced in in cultured muscle.
The New England journal of medicine 1976;294(11):573-8.
1976: Valerie Askanas; W King Engel; S DiMauro; M Mehler; B R Brooks
Acid maltase deficiency: reincarnation in cultured muscle fibers of the typical morphological and biochemical defects.
Transactions of the American Neurological Association 1976;101():174-5.
1976: W King Engel; Valerie Askanas
Remote effects of focal cancer on the neuromuscular system.
Advances in neurology 1976;15():119-47.
1975: Valerie Askanas; W King Engel
Chick muscle in tissue culture: the ubiquity of viral infection.
Acta neuropathologica 1975;32(4):271-9.
1975: Valerie Askanas; W King Engel
Distinct subtypes of type I fibers of human skeletal muscle.
Neurology 1975;25(9):879-87.
1975: Valerie Askanas; W King Engel
Letters to the editor: A technique of fiber selection from human muscle tissue cultures for histochemical-electronmicroscopic studies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1975;23(2):144-6.
1975: W King Engel; S C Bean; Valerie Askanas
Letter: The many causes of "idiopathic" scoliosis.
Lancet 1975;1(7900):228.
1975: Valerie Askanas; W King Engel
Distinct histochemical subtypes of type I fibers of human skeletal muscle.
Transactions of the American Neurological Association 1975;100():161-3.
1975: Valerie Askanas; W King Engel
A new program for investigating adult human skeletal muscle grown aneurally in tissue culture.
Neurology 1975;25(1):58-67.
1974: Valerie Askanas; D Hee
Histochemical and tissue culture studies of dystrophic and experimentally denervated animal muscle.
Journal of neuropathology and experimental neurology 1974;33(4):541-51.
1973: Valerie Askanas; D Hee
Histochemistry of cultured, embryonic and regenerating rat muscle.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1973;21(9):785-93.
1972: Valerie Askanas; S A Shafiq; A T Milhorat
Histochemistry of cultured aneural chick muscle. Morphological maturation without differentiation of fiber types.
Experimental neurology 1972;37(1):218-30.
1972: S A Shafiq; Valerie Askanas; S A Asiedu; A T Milhorat
Structural changes in human and chicken muscular dystrophy.
Muscle biology 1972;1():255-72.
1971: S A Shafiq; Valerie Askanas; A T Milhorat
Fiber types and preclinical changes in chicken muscular dystrophy.
Archives of neurology 1971;25(6):560-71.
1971: Valerie Askanas; S A Shafiq; D Adamchak
Sandwich embedding of multiple layers of muscle tissue culture for serial frozen sectioning.
Stain technology 1971;46(6):322-4.
1971: Valerie Askanas; S A Shafiq; A T Milhorat
Normal and dystrophic chicken muscle at successive stages in tissue culture.
Archives of neurology 1971;24(3):259-65.