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Christian Herrmann

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Phenomena

Protein Binding

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Procedures

Physiology

Signal Transduction

Occupations

Thermodynamics

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Network (preview)

Co-Publications
Name
20
Wittinghofer, Alfred
15
Kalbitzer, Hans Robert
8
Geyer, Matthias
8
Praefcke, Gerrit
8
Wohlgemuth, Sabine
6
Linnemann, Thomas
5
Kiel, Christina
5
Spoerner, Michael
4
Engelhard, Martin
4
Vetter, Ingrid
4
Müller, Oliver
3
Prakash, Balaji
3
Renault, Louis
3
Block, C
3
Huber, F

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Publications

TOP 3
Kiel Christina; Filchtinski Daniel; Spoerner Michael; Schreiber Gideon; Kalbitzer Hans Robert; Herrmann Christian
Improved binding of raf to Ras.GDP is correlated with biological activity.
Brockmeier Achim; Skopnik Manuel; Koch Brigitte; Herrmann Christian; Hengstenberg Wolfgang; Welti Stefan; Scheffzek Klaus
Activity of the Enterococcus faecalis EIIA(gnt) PTS component and its strong interaction with EIIB(gnt).
Köster Stefan; Wehner Mark; Herrmann Christian; Kühlbrandt Werner; Yildiz Ozkan
Structure and function of the FeoB G-domain from Methanococcus jannaschii.

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All Publications

2009: Kiel Christina; Filchtinski Daniel; Spoerner Michael; Schreiber Gideon; Kalbitzer Hans Robert; Herrmann Christian
Improved binding of raf to Ras.GDP is correlated with biological activity.
The Journal of biological chemistry 2009;284(46):31893-902.
2009: Brockmeier Achim; Skopnik Manuel; Koch Brigitte; Herrmann Christian; Hengstenberg Wolfgang; Welti Stefan; Scheffzek Klaus
Activity of the Enterococcus faecalis EIIA(gnt) PTS component and its strong interaction with EIIB(gnt).
Biochemical and biophysical research communications 2009;388(4):630-6.
2009: Köster Stefan; Wehner Mark; Herrmann Christian; Kühlbrandt Werner; Yildiz Ozkan
Structure and function of the FeoB G-domain from Methanococcus jannaschii.
Journal of molecular biology 2009;392(2):405-19.
2009: Vöpel Tobias; Kunzelmann Simone; Herrmann Christian
Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis.
FEBS letters 2009;583(12):1923-7.
2008: Wilbert Jürgen; Meyer Jürgen; Baier Kurt; Guckenberger Matthias; Herrmann Christian; Hess Robin; Janka Christian; Ma Lei; Mersebach Torben; Richter Anne; Roth Michael; Schilling Klaus; Flentje Michael
Tumor tracking and motion compensation with an adaptive tumor tracking system (ATTS): system description and prototype testing.
Medical physics 2008;35(9):3911-21.
2008: Filchtinski Daniel; Bee Christine; Savopol Tudor; Engelhard Martin; Becker Christian F W; Herrmann Christian
Probing ras effector interactions on nanoparticle supported lipid bilayers.
Bioconjugate chemistry 2008;19(9):1938-44.
2008: Stieglitz Benjamin; Bee Christine; Schwarz Daniel; Yildiz Ozkan; Moshnikova Anna; Khokhlatchev Andrei; Herrmann Christian
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.
The EMBO journal 2008;27(14):1995-2005.
2007: Spoerner Michael; Nuehs Andrea; Herrmann Christian; Steiner Guido; Kalbitzer Hans Robert
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.
The FEBS journal 2007;274(6):1419-33.
2007: Constantinescu Diana; Weingärtner Hermann; Herrmann Christian
Protein denaturation by ionic liquids and the Hofmeister series: a case study of aqueous solutions of ribonuclease A.
Angewandte Chemie (International ed. in English) 2007;46(46):8887-9.
2006: Kunzelmann Simone; Praefcke Gerrit J K; Herrmann Christian
Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1).
The Journal of biological chemistry 2006;281(39):28627-35.
2006: Harjes Elena; Harjes Stefan; Wohlgemuth Sabine; Müller Karl-Heinz; Krieger Elmar; Herrmann Christian; Bayer Peter
GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.
Structure (London, England : 1993) 2006;14(5):881-8.
2006: Ghosh Agnidipta; Praefcke Gerrit J K; Renault Louis; Wittinghofer Alfred; Herrmann Christian
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature 2006;440(7080):101-4.
2005: Wohlgemuth Sabine; Kiel Christina; Krämer Astrid; Serrano Luis; Wittinghofer Fred; Herrmann Christian
Recognizing and defining true Ras binding domains I: biochemical analysis.
Journal of molecular biology 2005;348(3):741-58.
2005: Spoerner Michael; Nuehs Andrea; Ganser Petra; Herrmann Christian; Wittinghofer Alfred; Kalbitzer Hans Robert
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Biochemistry 2005;44(6):2225-36.
2005: Kunzelmann Simone; Praefcke Gerrit J K; Herrmann Christian
Nucleotide binding and self-stimulated GTPase activity of human guanylate-binding protein 1 (hGBP1).
Methods in enzymology 2005;404():512-27.
2004: Praefcke Gerrit J K; Kloep Stephan; Benscheid Utz; Lilie Hauke; Prakash Balaji; Herrmann Christian
Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis.
Journal of molecular biology 2004;344(1):257-69.
2004: Ghosh Agnidipta; Uthaiah Revathy; Howard Jonathan; Herrmann Christian; Wolf Eva
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.
Molecular cell 2004;15(5):727-39.
2004: Kiel Christina; Serrano Luis; Herrmann Christian
A detailed thermodynamic analysis of ras/effector complex interfaces.
Journal of molecular biology 2004;340(5):1039-58.
2004: Kiel C; Selzer T; Shaul Y; Schreiber G; Herrmann C
Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9223-8.
2004: Waldmann Herbert; Karaguni Ioanna-Maria; Carpintero Mercedes; Gourzoulidou Eleni; Herrmann Christian; Brockmann Christoph; Oschkinat Hartmut; Müller Oliver
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.
Angewandte Chemie (International ed. in English) 2004;43(4):454-8.
2004: Müller Oliver; Gourzoulidou Eleni; Carpintero Mercedes; Karaguni Ioanna-Maria; Langerak Anette; Herrmann Christian; Möröy Tarik; Klein-Hitpass Ludger; Waldmann Herbert
Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.
Angewandte Chemie (International ed. in English) 2004;43(4):450-4.
2003: Uthaiah Revathy C; Praefcke Gerrit J K; Howard Jonathan C; Herrmann Christian
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization.
The Journal of biological chemistry 2003;278(31):29336-43.
2003: Hippler-Mreyen Silke; Klare Johann P; Wegener Ansgar A; Seidel Ralf; Herrmann Christian; Schmies Georg; Nagel Georg; Bamberg Ernst; Engelhard M
Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology.
Journal of molecular biology 2003;330(5):1203-13.
2003: Tickenbrock Lara; Kössmeier Katja; Rehmann Holger; Herrmann Christian; Müller Oliver
Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein.
Journal of molecular biology 2003;327(2):359-67.
2003: Herrmann Christian
Ras-effector interactions: after one decade.
Current opinion in structural biology 2003;13(1):122-9.
2002: Stumber Michael; Herrmann Christian; Wohlgemuth Sabine; Kalbitzer Hans Robert; Jahn Werner; Geyer Matthias
Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPgammaNH(2) and GTPgammaF.
European journal of biochemistry / FEBS 2002;269(13):3270-8.
2002: Dursina Beatrice; Thomä Nicolas H; Sidorovitch Vadim; Niculae Anca; Iakovenko Andrei; Rak Alexy; Albert Stefan; Ceacareanu Alice-Corina; Kölling Ralf; Herrmann Christian; Goody Roger S; Alexandrov Kirill
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.
Biochemistry 2002;41(21):6805-16.
2002: Linnemann Thomas; Kiel Christina; Herter Peter; Herrmann Christian
The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution.
The Journal of biological chemistry 2002;277(10):7831-7.
2002: Ahmadian Mohammad Reza; Wittinghofer Alfred; Herrmann Christian
Fluorescence methods in the study of small GTP-binding proteins.
Methods in molecular biology (Clifton, N.J.) 2002;189():45-63.
2001: Scheffzek K; Grünewald P; Wohlgemuth S; Kabsch W; Tu H; Wigler M; Wittinghofer A; Herrmann C
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure (London, England : 1993) 2001;9(11):1043-50.
2001: Gronwald W; Huber F; Grünewald P; Spörner M; Wohlgemuth S; Herrmann C; Kalbitzer H R
Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe.
Structure (London, England : 1993) 2001;9(11):1029-41.
2001: Inoue K; Maurer T; Yamada H; Herrmann C; Horn G; Kalbitzer H R; Akasaka K
High-pressure NMR study of the complex of a GTPase Rap1A with its effector RalGDS. A conformational switch in RalGDS revealed from non-linear pressure shifts.
FEBS letters 2001;506(3):180-4.
2001: Gronwald W; Brunner E; Huber F; Wenzler M; Herrmann C; Kalbitzer H R
Overcoming the problems associated with poor spectra quality of the protein kinase Byr2 using residual dipolar couplings.
Protein science : a publication of the Protein Society 2001;10(6):1260-3.
2001: Rudolph M G; Linnemann T; Grunewald P; Wittinghofer A; Vetter I R; Herrmann C
Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry.
The Journal of biological chemistry 2001;276(26):23914-21.
2001: Spoerner M; Herrmann C; Vetter I R; Kalbitzer H R; Wittinghofer A
Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4944-9.
2001: Groemping Y; Klostermeier D; Herrmann C; Veit T; Seidel R; Reinstein J
Regulation of ATPase and chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE.
Journal of molecular biology 2001;305(5):1173-83.
2000: Steiner G; Kremer W; Linnemann T; Herrmann C; Geyer M; Kalbitzer H R
Sequence-specific resonance assignment of the Ras-binding domain of AF6.
Journal of biomolecular NMR 2000;18(1):73-4.
2000: Prakash B; Renault L; Praefcke G J; Herrmann C; Wittinghofer A
Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism.
The EMBO journal 2000;19(17):4555-64.
2000: Vetter I R; Hofmann F; Wohlgemuth S; Herrmann C; Just I
Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin.
Journal of molecular biology 2000;301(5):1091-5.
2000: Inoue K; Yamada H; Akasaka K; Herrmann C; Kremer W; Maurer T; Döker R; Kalbitzer H R
Pressure-induced local unfolding of the Ras binding domain of RalGDS.
Nature structural biology 2000;7(7):547-50.
2000: Huber F; Gronwald W; Wohlgemuth S; Herrmann C; Geyer M; Wittinghofer A; Kalbitzer H R
Sequential NMR assignment of the RAS-binding domain of Byr2.
Journal of biomolecular NMR 2000;16(4):355-6.
2000: Prakash B; Praefcke G J; Renault L; Wittinghofer A; Herrmann C
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.
Nature 2000;403(6769):567-71.
2000: Weber C K; Slupsky J R; Herrmann C; Schuler M; Rapp U R; Block C
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes.
Oncogene 2000;19(2):169-76.
1999: Praefcke G J; Geyer M; Schwemmle M; Robert Kalbitzer H; Herrmann C
Nucleotide-binding characteristics of human guanylate-binding protein 1 (hGBP1) and identification of the third GTP-binding motif.
Journal of molecular biology 1999;292(2):321-32.
1999: Sydor J R; Herrmann C; Kent S B; Goody R S; Engelhard M
Design, total chemical synthesis, and binding properties of a [Leu-91-N1-methyl-7-azaTrp]Ras-binding domain of c-Raf-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7865-70.
1999: Vetter I R; Linnemann T; Wohlgemuth S; Geyer M; Kalbitzer H R; Herrmann C; Wittinghofer A
Structural and biochemical analysis of Ras-effector signaling via RalGDS.
FEBS letters 1999;451(2):175-80.
1999: Linnemann T; Geyer M; Jaitner B K; Block C; Kalbitzer H R; Wittinghofer A; Herrmann C
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.
The Journal of biological chemistry 1999;274(19):13556-62.
1998: Herrmann C; Block C; Geisen C; Haas K; Weber C; Winde G; Möröy T; Müller O
Sulindac sulfide inhibits Ras signaling.
Oncogene 1998;17(14):1769-76.
1998: Sydor J R; Engelhard M; Wittinghofer A; Goody R S; Herrmann C
Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex.
Biochemistry 1998;37(40):14292-9.
1998: Herrmann C; Ahmadian M R; Hofmann F; Just I
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.
The Journal of biological chemistry 1998;273(26):16134-9.
1997: Jaitner B K; Becker J; Linnemann T; Herrmann C; Wittinghofer A; Block C
Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis.
The Journal of biological chemistry 1997;272(47):29927-33.
1997: Geyer M; Herrmann C; Wohlgemuth S; Wittinghofer A; Kalbitzer H R
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nature structural biology 1997;4(9):694-9.
1996: Geyer M; Schweins T; Herrmann C; Prisner T; Wittinghofer A; Kalbitzer H R
Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.
Biochemistry 1996;35(32):10308-20.
1996: Nassar N; Horn G; Herrmann C; Block C; Janknecht R; Wittinghofer A
Ras/Rap effector specificity determined by charge reversal.
Nature structural biology 1996;3(8):723-9.
1996: Herrmann C; Horn G; Spaargaren M; Wittinghofer A
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor.
The Journal of biological chemistry 1996;271(12):6794-800.
1996: Block C; Janknecht R; Herrmann C; Nassar N; Wittinghofer A
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo.
Nature structural biology 1996;3(3):244-51.
1996: Herrmann C; Nassar N
Ras and its effectors.
Progress in biophysics and molecular biology 1996;66(1):1-41.
1995: Wittinghofer A; Herrmann C
Ras-effector interactions, the problem of specificity.
FEBS letters 1995;369(1):52-6.
1995: Nassar N; Horn G; Herrmann C; Scherer A; McCormick F; Wittinghofer A
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature 1995;375(6532):554-60.
1995: Herrmann C; Martin G A; Wittinghofer A
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase.
The Journal of biological chemistry 1995;270(7):2901-5.

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