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Alon Herschhorn

Research Profile

Chemicals & Drugs

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HIV-1

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Publications

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Anik Désormeaux; Mathieu Coutu; Christopher Gu; Alon Herschhorn; Youdong Mao; Halima Medjahed; Beatriz Pacheco; Joseph Sodroski; Shi-Hua Xiang; Andrés Finzi
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
Youdong Mao; Christopher Gu; Hillel Haim; Alon Herschhorn; Liping Wang; Shi-Hua Xiang; Xinzhen Yang; Joseph Sodroski
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.
Andrés Finzi; Alon Herschhorn; Peter D Kwong; Beatriz Pacheco; Marie Pancera; Liping Wang; Shi-Hua Xiang; Xing Zeng; Anik Desormeaux; Joseph Sodroski
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.

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All Publications

2013: Anik Désormeaux; Mathieu Coutu; Christopher Gu; Alon Herschhorn; Youdong Mao; Halima Medjahed; Beatriz Pacheco; Joseph Sodroski; Shi-Hua Xiang; Andrés Finzi
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
Journal of virology 2013;87(5):2549-62.
2012: Youdong Mao; Christopher Gu; Hillel Haim; Alon Herschhorn; Liping Wang; Shi-Hua Xiang; Xinzhen Yang; Joseph Sodroski
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.
Nature structural & molecular biology 2012;19(9):893-9.
2012: Andrés Finzi; Alon Herschhorn; Peter D Kwong; Beatriz Pacheco; Marie Pancera; Liping Wang; Shi-Hua Xiang; Xing Zeng; Anik Desormeaux; Joseph Sodroski
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.
Journal of virology 2012;86(17):8974-86.
2011: Michal Weitman; Keti Lerman; Abraham Nudelman; Dan Thomas Major; Amnon Hizi; Alon Herschhorn
Structure--activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1.
European journal of medicinal chemistry 2011;46(2):447-67.
2011: Iris Oz Gleenberg; Alon Herschhorn; Amnon Hizi
Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesis.
Nucleic acids research 2011;39(3):1042-53.
2011: Alon Herschhorn; David M Jones; Amos B Smith; Joel R Courter; Andres Finzi; Akihiro Sugawara; Joseph G Sodroski
An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.
PloS one 2011;6(11):e26731.
2010: Alon Herschhorn; Wayne A Marasco; Amnon Hizi
Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7623-32.
2010: Alon Herschhorn; Amnon Hizi
Retroviral reverse transcriptases.
Cellular and molecular life sciences : CMLS 2010;67(16):2717-47.
2008: Alon Herschhorn; Amnon Hizi
Virtual screening, identification, and biochemical characterization of novel inhibitors of the reverse transcriptase of human immunodeficiency virus type-1.
Journal of medicinal chemistry 2008;51(18):5702-13.
2008: Amnon Hizi; Alon Herschhorn
Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): a comparison of their molecular and biochemical properties.
Virus research 2008;134(1-2):203-20.
2008: Alon Herschhorn; Iris Oz Gleenberg; Amnon Hizi
Quantitative analysis of the interactions between HIV-1 integrase and retroviral reverse transcriptases.
The Biochemical journal 2008;412(1):163-70.
2008: Alon Herschhorn; Iris Oz Gleenberg; Amnon Hizi
Mechanism of inhibition of HIV-1 reverse transcriptase by the novel broad-range DNA polymerase inhibitor N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide.
Biochemistry 2008;47(1):490-502.
2007: Iris Oz Gleenberg; Alon Herschhorn; Amnon Hizi
Inhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr).
Journal of molecular biology 2007;369(5):1230-43.
2007: Alon Herschhorn; Lena Lerman; Michal Weitman; Iris Oz Gleenberg; Abraham Nudelman; Amnon Hizi
De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants.
Journal of medicinal chemistry 2007;50(10):2370-84.
2007: Iris Oz Gleenberg; Alon Herschhorn; Yehuda Goldgur; Amnon Hizi
Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.
Archives of biochemistry and biophysics 2007;458(2):202-12.
2005: Iris Oz Gleenberg; Orna Avidan; Yehuda Goldgur; Alon Herschhorn; Amnon Hizi
Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.
The Journal of biological chemistry 2005;280(23):21987-96.
2003: Alon Herschhorn; Arie Admon; Amnon Hizi
Recombinant human antibodies against the reverse transcriptase of human immunodeficiency virus type-1.
Biochimica et biophysica acta 2003;1648(1-2):154-63.