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Louis Hersh

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Rats
Mice

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Amino Acid Sequence

Anatomy

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Alzheimer Disease

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Co-Publications
Name
10
Juliano, Maria Aparecida
9
Juliano, Luiz
8
Hirsch, Etienne
8
Chow, Martin
8
Cottam, GL
8
Csuhai, Eva
8
Song, Eun Suk
7
Shimojo, Masahito
7
Agid, Yves
7
Geula, Changiz
7
Ma, Zhangliang
6
Kim, Myung-Hee
6
Gage, Fred
5
Mufson, Elliott
5
Saper, Clifford

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Publications

TOP 3
Liu Yinxing; Studzinski Christa; Beckett Tina; Guan Hanjun; Hersh Matthew A; Murphy M Paul; Klein Ronald; Hersh Louis B
Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease.
Guan Hanjun; Liu Yinxing; Daily Abigail; Police Sara; Kim Myung-Hee; Oddo Salvatore; LaFerla Frank M; Pauly James R; Murphy M Paul; Hersh Louis B
Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.
Chow K Martin; Gakh O; Payne I C; Juliano Maria Aparecida; Juliano Luiz; Isaya G; Hersh Louis B
Mammalian pitrilysin: substrate specificity and mitochondrial targeting.

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All Publications

2009: Liu Yinxing; Studzinski Christa; Beckett Tina; Guan Hanjun; Hersh Matthew A; Murphy M Paul; Klein Ronald; Hersh Louis B
Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1381-6.
2009: Guan Hanjun; Liu Yinxing; Daily Abigail; Police Sara; Kim Myung-Hee; Oddo Salvatore; LaFerla Frank M; Pauly James R; Murphy M Paul; Hersh Louis B
Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.
Journal of neuroscience research 2009;87(6):1462-73.
2009: Chow K Martin; Gakh O; Payne I C; Juliano Maria Aparecida; Juliano Luiz; Isaya G; Hersh Louis B
Mammalian pitrilysin: substrate specificity and mitochondrial targeting.
Biochemistry 2009;48(13):2868-77.
2009: Dempsey Edward C; Wick Marilee J; Karoor Vijaya; Barr Erica J; Tallman Dustin W; Wehling Carol A; Walchak Sandra J; Laudi Sven; Le Mysan; Oka Masahiko; Majka Susan; Cool Carlyne D; Fagan Karen A; Klemm Dwight J; Hersh Louis B; Gerard Norma P; Gerard Craig; Miller York E
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia.
The American journal of pathology 2009;174(3):782-96.
2009: Rose John B; Crews Leslie; Rockenstein Edward; Adame Anthony; Mante Michael; Hersh Louis B; Gage Fred H; Spencer Brian; Potkar Rewati; Marr Robert A; Masliah Eliezer
Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):1115-25.
2008: Hersh Louis B; Rodgers David W
Neprilysin and amyloid beta peptide degradation.
Current Alzheimer research 2008;5(2):225-31.
2008: Horiguchi A; Chen D Y T; Goodman O B; Zheng R; Shen R; Guan H; Hersh L B; Nanus D M
Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis.
Prostate cancer and prostatic diseases 2008;11(1):79-87.
2007: Liu Yinxing; Guan Hanjun; Beckett Tina L; Juliano Maria Aparecida; Juliano Luiz; Song Eun Suk; Chow K Martin; Murphy M Paul; Hersh Louis B
In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes.
Peptides 2007;28(12):2348-55.
2007: Horiguchi A; Zheng R; Goodman O B; Shen R; Guan H; Hersh L B; Nanus D M
Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth.
Cancer gene therapy 2007;14(6):583-9.
2007: Kim Minji; Hersh Louis B; Leissring Malcolm A; Ingelsson Martin; Matsui Toshifumi; Farris Wesley; Lu Alice; Hyman Bradley T; Selkoe Dennis J; Bertram Lars; Tanzi Rudolph E
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Yao Jia; Hersh Louis B
The vesicular monoamine transporter 2 contains trafficking signals in both its N-glycosylation and C-terminal domains.
Journal of neurochemistry 2007;100(5):1387-96.
2006: Song Eun Suk; Cady Clint; Fried Michael G; Hersh Louis B
Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation.
Biochemistry 2006;45(50):15085-91.
2006: Hersh L B
The insulysin (insulin degrading enzyme) enigma.
Cellular and molecular life sciences : CMLS 2006;63(21):2432-4.
2006: Stricker Rolf; Chow K Martin; Walther Daniela; Hanck Theodor; Hersh Louis B; Reiser Georg
Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.
Journal of neurochemistry 2006;98(2):343-54.
2006: Yao Hongbing; Hersh Louis B
Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin.
Archives of biochemistry and biophysics 2006;451(2):175-81.
2006: Daily Abigail; Nath Avindra; Hersh Louis B
Tat peptides inhibit neprilysin.
Journal of neurovirology 2006;12(3):153-60.
2006: Shimojo Masahito; Hersh Louis B
Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF.
Journal of neurochemistry 2006;96(4):1130-8.
2005: Shinall Heather; Song Eun Suk; Hersh Louis B
Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral.
Biochemistry 2005;44(46):15345-50.
2005: Chow K Martin; Ma Zhangliang; Cai Jian; Pierce William M; Hersh Louis B
Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase.
Biochimica et biophysica acta 2005;1723(1-3):292-301.
2005: Song Eun Suk; Daily Abigail; Fried Michael G; Juliano Maria Aparecida; Juliano Luiz; Hersh Louis B
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions.
The Journal of biological chemistry 2005;280(18):17701-6.
2005: Lazarov Orly; Robinson John; Tang Ya-Ping; Hairston Ilana S; Korade-Mirnics Zeljka; Lee Virginia M-Y; Hersh Louis B; Sapolsky Robert M; Mirnics Karoly; Sisodia Sangram S
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Cell 2005;120(5):701-13.
2005: Ma Zhangliang; Wang Xuebing; Hockman Steven; Snow E Charles; Hersh Louis B
Subcellular localization of nardilysin during mouse oocyte maturation.
Archives of biochemistry and biophysics 2005;434(1):187-94.
2005: Ertekin-Taner Nilüfer; Ronald James; Feuk Lars; Prince Jonathan; Tucker Michael; Younkin Linda; Hella Maria; Jain Shushant; Hackett Alyssa; Scanlin Leah; Kelly Jason; Kihiko-Ehman Muthoni; Neltner Matthew; Hersh Louis; Kindy Mark; Markesbery William; Hutton Michael; de Andrade Mariza; Petersen Ronald C; Graff-Radford Neill; Estus Steve; Brookes Anthony J; Younkin Steven G
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Human molecular genetics 2005;14(3):447-60.
2005: Nath Avindra; Hersh Louis B
Tat and amyloid: multiple interactions.
AIDS (London, England) 2005;19(2):203-4.
2005: Song Eun Suk; Hersh Louis B
Insulysin: an allosteric enzyme as a target for Alzheimer's disease.
Journal of molecular neuroscience : MN 2005;25(3):201-6.
2004: Yao Jia; Erickson Jeffrey D; Hersh Louis B
Protein kinase A affects trafficking of the vesicular monoamine transporters in PC12 cells.
Traffic (Copenhagen, Denmark) 2004;5(12):1006-16.
2004: Song Eun Suk; Juliano Maria Aparecida; Juliano Luiz; Fried Michael G; Wagner Steven L; Hersh Louis B
ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.
The Journal of biological chemistry 2004;279(52):54216-20.
2004: Huang Jian; Guan Hanjun; Booze Rosemarie M; Eckman Christopher B; Hersh Louis B
Estrogen regulates neprilysin activity in rat brain.
Neuroscience letters 2004;367(1):85-7.
2004: Cai Yiying; Cronin Ciarán N; Engel Andrew G; Ohno Kinji; Hersh Louis B; Rodgers David W
Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders.
The EMBO journal 2004;23(10):2047-58.
2004: Shimojo Masahito; Hersh Louis B
Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF).
Life sciences 2004;74(18):2213-25.
2004: Kim Myung-Hee; Hersh Louis B
The vesicular acetylcholine transporter interacts with clathrin-associated adaptor complexes AP-1 and AP-2.
The Journal of biological chemistry 2004;279(13):12580-7.
2004: Ma Zhangliang; Chow K Martin; Yao Jia; Hersh Louis B
Nuclear shuttling of the peptidase nardilysin.
Archives of biochemistry and biophysics 2004;422(2):153-60.
2004: Marr Robert A; Guan Hanjun; Rockenstein Edward; Kindy Mark; Gage Fred H; Verma Inder; Masliah Eliezer; Hersh Louis B
Neprilysin regulates amyloid Beta peptide levels.
Journal of molecular neuroscience : MN 2004;22(1-2):5-11.
2003: Whitaker Chastity; Eckman Chris; Almeida Claudia; Feinstein Douglas; Atwood Craig; Eckman Elizabeth; Crutcher Keith; Hersh Lou; Leissring Malcolm; LaVoie Matthew; Ertekin-Taner Nilufer; Shapiro Paul; Takahashi Reisuke; Yamin Rina; Mansourian Stefan; Estus Steve; Lesné Sylvain; Turner Tony; Farris Wes; Stroebel Gabrielle
Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002.
Journal of Alzheimer's disease : JAD 2003;5(6):491-7.
2003: Shimojo Masahito; Hersh Louis B
REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.
Molecular and cellular biology 2003;23(24):9025-31.
2003: Song Eun-Suk; Juliano Maria Aparecida; Juliano Luiz; Hersh Louis B
Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.
The Journal of biological chemistry 2003;278(50):49789-94.
2003: Thompson Michael W; Hersh Louis B
Analysis of conserved residues of the human puromycin-sensitive aminopeptidase.
Peptides 2003;24(9):1359-65.
2003: Ma Zhangliang; Daquin Alex; Yao Jia; Rodgers David; Thompson Michael W; Hersh Louis B
Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain.
Archives of biochemistry and biophysics 2003;415(1):80-6.
2003: Yamada Elizabeth S; Dmitrieva Nina; Keyser Kent T; Lindstrom Jon M; Hersh Louis B; Marshak David W
Synaptic connections of starburst amacrine cells and localization of acetylcholine receptors in primate retinas.
The Journal of comparative neurology 2003;461(1):76-90.
2003: Miller Bonnie C; Eckman Elizabeth A; Sambamurti Kumar; Dobbs Nicole; Chow K Martin; Eckman Christopher B; Hersh Louis B; Thiele Dwain L
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6221-6.
2003: Thompson Michael W; Govindaswami Meera; Hersh Louis B
Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein.
Archives of biochemistry and biophysics 2003;413(2):236-42.
2003: Kim Myung-Hee; Lu Mei; Rogers Gary; Parsons Stanley; Hersh Louis B
Specificity of the rat vesicular acetylcholine transporter.
Neurochemical research 2003;28(3-4):473-6.
2003: Marr Robert A; Rockenstein Edward; Mukherjee Atish; Kindy Mark S; Hersh Louis B; Gage Fred H; Verma Inder M; Masliah Eliezer
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):1992-6.
2003: Hersh Louis B; Shimojo Masahito
Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor.
Life sciences 2003;72(18-19):2021-8.
2003: Chow K Martin; Oakley Oliver; Goodman Jack; Ma Zhangliang; Juliano Maria Aparecida; Juliano Luiz; Hersh Louis B
Nardilysin cleaves peptides at monobasic sites.
Biochemistry 2003;42(7):2239-44.
2003: Wu C-K; Nagykery N; Hersh L B; Scinto L F M; Geula C
Selective age-related loss of calbindin-D28k from basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus).
Neuroscience 2003;120(1):249-59.
2003: Hersh Louis B
Peptidases, proteases and amyloid beta-peptide catabolism.
Current pharmaceutical design 2003;9(6):449-54.
2002: Mukherjee Atish; Hersh Louis B
Regulation of amyloid beta-peptide levels by enzymatic degradation.
Journal of Alzheimer's disease : JAD 2002;4(5):341-8.
2002: Ma Zhangliang; Chow K Martin; Csuhai Eva; Hersh Louis B
The use of proteolysis to study the structure of nardilysin.
Archives of biochemistry and biophysics 2002;401(2):198-204.
2002: Fischer Hanspeter S; Zernig Gerald; Hauser Kurt F; Gerard Craig; Hersh Louis B; Saria Alois
Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide.
Journal of molecular neuroscience : MN 2002;18(1-2):129-34.
2001: Ma Z; Csuhai E; Chow K M; Hersh L B
Expression of the acidic stretch of nardilysin as a functional binding domain.
Biochemistry 2001;40(31):9447-52.
2001: Shimojo M; Lee J H; Hersh L B
Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization.
The Journal of biological chemistry 2001;276(16):13121-6.
2001: Song E S; Mukherjee A; Juliano M A; Pyrek J S; Goodman J P; Juliano L; Hersh L B
Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates.
The Journal of biological chemistry 2001;276(2):1152-5.
2000: Lee J H; Chai Y G; Hersh L B
Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma.
Journal of molecular neuroscience : MN 2000;15(3):205-14.
2000: Shen R; Sumitomo M; Dai J; Hardy D O; Navarro D; Usmani B; Papandreou C N; Hersh L B; Shipp M A; Freedman L P; Nanus D M
Identification and characterization of two androgen response regions in the human neutral endopeptidase gene.
Molecular and cellular endocrinology 2000;170(1-2):131-42.
2000: Mukherjee A; Song E; Kihiko-Ehmann M; Goodman J P; Pyrek J S; Estus S; Hersh L B
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(23):8745-9.
2000: Lian W; Chen G; Wu D; Brown C K; Madauss K; Hersh L B; Rodgers D W
Crystallization and preliminary analysis of neurolysin.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 12):1644-6.
2000: Stoltze L; Schirle M; Schwarz G; Schröter C; Thompson M W; Hersh L B; Kalbacher H; Stevanovic S; Rammensee H G; Schild H
Two new proteases in the MHC class I processing pathway.
Nature immunology 2000;1(5):413-8.
2000: Wu C K; Hersh L B; Geula C
Cyto- and chemoarchitecture of basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus).
Experimental neurology 2000;165(2):306-26.
2000: Lee J H; Shimojo M; Chai Y G; Hersh L B
Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element.
Brain research. Molecular brain research 2000;80(1):88-98.
2000: Siems W; Maul B; Krause W; Gerard C; Hauser K F; Hersh L B; Fischer H S; Zernig G; Saria A
Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice.
European journal of pharmacology 2000;397(2-3):327-34.
2000: Chow K M; Csuhai E; Juliano M A; St Pyrek J; Juliano L; Hersh L B
Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase).
The Journal of biological chemistry 2000;275(26):19545-51.
2000: Cho G W; Kim M H; Chai Y G; Gilmor M L; Levey A I; Hersh L B
Phosphorylation of the rat vesicular acetylcholine transporter.
The Journal of biological chemistry 2000;275(26):19942-8.
2000: Kim M H; Lu M; Kelly M; Hersh L B
Mutational analysis of basic residues in the rat vesicular acetylcholine transporter. Identification of a transmembrane ion pair and evidence that histidine is not involved in proton translocation.
The Journal of biological chemistry 2000;275(9):6175-80.
1999: Shimojo M; Paquette A J; Anderson D J; Hersh L B
Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST.
Molecular and cellular biology 1999;19(10):6788-95.
1999: Gilmor M L; Erickson J D; Varoqui H; Hersh L B; Bennett D A; Cochran E J; Mufson E J; Levey A I
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease.
The Journal of comparative neurology 1999;411(4):693-704.
1999: Nambi P; Pullen M; Wu H L; Prabhakar U; Hersh L; Gellai M
Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: possible mechanism for ischemia-induced acute renal failure in rats?
Molecular and cellular biochemistry 1999;197(1-2):53-9.
1999: Thompson M W; Tobler A; Fontana A; Hersh L B
Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase.
Biochemical and biophysical research communications 1999;258(2):234-40.
1999: Csuhai E; Juliano M A; Pyrek J S; Harms A C; Juliano L; Hersh L B
New fluorogenic substrates for N-arginine dibasic convertase.
Analytical biochemistry 1999;269(1):149-54.
1999: Manaye K F; Zweig R; Wu D; Hersh L B; De Lacalle S; Saper C B; German D C
Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain.
Neuroscience 1999;89(3):759-70.
1999: Csuhai E; Juliano M A; Juliano L; Hersh L B
Kinetic analysis of spermine binding to NRD convertase.
Archives of biochemistry and biophysics 1999;362(2):291-300.
1999: Kim M H; Lu M; Lim E J; Chai Y G; Hersh L B
Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter.
The Journal of biological chemistry 1999;274(2):673-80.
1999: German D C; Manaye K F; Wu D; Hersh L B; Zweig R M
Mesopontine cholinergic and non-cholinergic neurons in schizophrenia.
Neuroscience 1999;94(1):33-8.
1999: Holt D J; Herman M M; Hyde T M; Kleinman J E; Sinton C M; German D C; Hersh L B; Graybiel A M; Saper C B
Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia.
Neuroscience 1999;94(1):21-31.
1998: Qiu W Q; Walsh D M; Ye Z; Vekrellis K; Zhang J; Podlisny M B; Rosner M R; Safavi A; Hersh L B; Selkoe D J
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
The Journal of biological chemistry 1998;273(49):32730-8.
1998: Ohkubo K; Baraniuk J N; Hohman R; Merida M; Hersh L B; Kaliner M A
Aminopeptidase activity in human nasal mucosa.
The Journal of allergy and clinical immunology 1998;102(5):741-50.
1998: Li C; Hersh L B
Characterization of the promoter region of the rat neprilysin gene.
Archives of biochemistry and biophysics 1998;358(1):189-95.
1998: Shimojo M; Wu D; Hersh L B
The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells.
Journal of neurochemistry 1998;71(3):1118-26.
1998: Li J Y; Dahlström A M; Hersh L B; Dahlström A
Fast axonal transport of the vesicular acetylcholine transporter (VAChT) in cholinergic neurons in the rat sciatic nerve.
Neurochemistry international 1998;32(5-6):457-67.
1998: Sarada B; Thiele D; Dang T; Lee J; Safavia A; Hersh L B; Cottam G L
Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE).
Journal of neuroimmunology 1998;85(1):59-68.
1998: Tanaka H; Zhao Y; Wu D; Hersh L B
The use of DNase I hypersensitivity site mapping to identify regulatory regions of the human cholinergic gene locus.
Journal of neurochemistry 1998;70(5):1799-808.
1998: Tanaka H; Shimojo M; Wu D; Hersh L B
Regulation of the cholinergic gene locus.
Journal of physiology, Paris 1998;92(2):149-52.
1998: Csuhai E; Chen G; Hersh L B
Regulation of N-arginine dibasic convertase activity by amines: putative role of a novel acidic domain as an amine binding site.
Biochemistry 1998;37(11):3787-94.
1998: Thiele D L; Sarada B; Dang T; Safavi A; Hersh L B; Cottam G L
Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells.
Advances in experimental medicine and biology 1998;437():291-300.
1997: Sarada B; Thiele D; Dang T; Safavi A; Hersh L B; Cottam G L
Increased expression of an endopeptidase (gamma-EGE/IDE) hydrolyzing beta-endorphin during differentiation and maturation of bone marrow macrophages.
Journal of leukocyte biology 1997;62(6):753-60.
1997: Saria A; Hauser K F; Traurig H H; Turbek C S; Hersh L; Gerard C
Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice.
Neuroscience letters 1997;234(1):27-30.
1997: Erbeznik H; Hersh L B
A novel mammalian high-molecular-weight aminopeptidase.
Archives of biochemistry and biophysics 1997;344(1):228-34.
1997: Baskin F; Li Y P; Hersh L B; Davis R M; Rosenberg R N
An AP-2 binding sequence within exon 1 of human and porcine choline acetyltransferase genes enhances transcription in neural cells.
Neuroscience 1997;76(3):821-7.
1997: Boissière F; Hunot S; Faucheux B; Hersh L B; Agid Y; Hirsch E C
Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease.
Dementia and geriatric cognitive disorders 1997;8(1):1-8.
1996: Safavi A; Miller B C; Cottam L; Hersh L B
Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme.
Biochemistry 1996;35(45):14318-25.
1996: Holt D J; Hersh L B; Saper C B
Cholinergic innervation in the human striatum: a three-compartment model.
Neuroscience 1996;74(1):67-87.
1996: Lian W; Wu D; Konings W N; Mierau I; Hersh L B
Heterologous expression and characterization of recombinant Lactococcus lactis neutral endopeptidase (neprilysin).
Archives of biochemistry and biophysics 1996;333(1):121-6.
1996: Miller B C; Thiele D; Hersh L B; Cottam G L
A secreted peptidase involved in T cell beta-endorphin metabolism.
Immunopharmacology 1996;31(2-3):151-61.
1996: Li C; Booze R M; Hersh L B
Tissue-specific expression of rat neutral endopeptidase mRNAs.
Annals of the New York Academy of Sciences 1996;780():145-55.
1996: Hersh L B; Inoue H; Li Y P
Transcriptional regulation of the human choline acetyltransferase gene.
Progress in brain research 1996;109():47-54.
1996: Safavi A; Miller B C; Hersh L B; Cottam G L
Purification and characterization of a secreted T cell beta-endorphin endopeptidase.
Advances in experimental medicine and biology 1996;402():71-9.
1995: Wu D; Hersh L B
Identification of an active site arginine in rat choline acetyltransferase by alanine scanning mutagenesis.
The Journal of biological chemistry 1995;270(49):29111-6.
1995: Constam D B; Tobler A R; Rensing-Ehl A; Kemler I; Hersh L B; Fontana A
Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization.
The Journal of biological chemistry 1995;270(45):26931-9.
1995: Li C; Chen G; Gerard N P; Gerard C; Bozic C R; Hersh L B
Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes.
Gene 1995;164(2):363-6.
1995: Vijayaragahaven J; Tucker M; Fehrentz J A; Isbell D; Hersh L B
Reaction of neprilysin (neutral endopeptidase) and thermolysin with cyclic peptides.
Archives of biochemistry and biophysics 1995;322(2):405-9.
1995: Csuhai E; Safavi A; Hersh L B
Purification and characterization of a secreted arginine-specific dibasic cleaving enzyme from EL-4 cells.
Biochemistry 1995;34(38):12411-9.
1995: Wu D; Ahmed S N; Lian W; Hersh L B
Activation of rat choline acetyltransferase by limited proteolysis.
The Journal of biological chemistry 1995;270(33):19395-401.
1995: Safavi A; Hersh L B
Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M.
Journal of neurochemistry 1995;65(1):389-95.
1995: Albrightson C R; Pullen M; Wu H L; Dytko G; Hersh L B; Nambi P
Thrombin-mediated down-regulation of endothelin receptors in mesangial cells coincides with the down-regulation of neutral endopeptidase activity.
Molecular pharmacology 1995;47(6):1156-63.
1995: Kioussi C; Mamalaki A; Jessen K; Mirsky R; Hersh L B; Matsas R
Expression of endopeptidase-24.11 (common acute lymphoblastic leukaemia antigen CD10) in the sciatic nerve of the adult rat after lesion and during regeneration.
The European journal of neuroscience 1995;7(5):951-61.
1995: Li Y P; Baskin F; Davis R; Wu D; Hersh L B
A cell type-specific silencer in the human choline acetyltransferase gene requiring two distinct and interactive E boxes.
Brain research. Molecular brain research 1995;30(1):106-14.
1995: Rodd D; Hersh L B
Endopeptidase 24.16B. A new variant of endopeptidase 24.16.
The Journal of biological chemistry 1995;270(17):10056-61.
1995: Li C; Booze R M; Hersh L B
Tissue-specific expression of rat neutral endopeptidase (neprilysin) mRNAs.
The Journal of biological chemistry 1995;270(11):5723-8.
1995: Inoue H; Li Y P; Wagner J A; Hersh L B
Expression of the choline acetyltransferase gene depends on protein kinase A activity.
Journal of neurochemistry 1995;64(3):985-90.
1995: Csuhai E; Little S S; Hersh L B
Inactivation of neuropeptides.
Progress in brain research 1995;104():131-42.
1995: Li C; Hersh L B
Neprilysin: assay methods, purification, and characterization.
Methods in enzymology 1995;248():253-63.
1995: Miller B C; Thiele D L; Rodd D; Hersh L B; Cottam G L
Active beta-endorphin metabolites generated by T-cell ectopeptidases.
Advances in experimental medicine and biology 1995;373():49-56.
1994: Gibbs R B; Wu D; Hersh L B; Pfaff D W
Effects of estrogen replacement on the relative levels of choline acetyltransferase, trkA, and nerve growth factor messenger RNAs in the basal forebrain and hippocampal formation of adult rats.
Experimental neurology 1994;129(1):70-80.
1994: Ransmayr G; Benesch H; Nowakowski C; Künig G; Heinsen H; Riederer P; Hersh L B
Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease.
Neuroscience letters 1994;177(1-2):11-4.
1994: De Lacalle S; Lim C; Sobreviela T; Mufson E J; Hersh L B; Saper C B
Cholinergic innervation in the human hippocampal formation including the entorhinal cortex.
The Journal of comparative neurology 1994;345(3):321-44.
1994: Selden N; Geula C; Hersh L; Mesulam M M
Human striatum: chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease.
Neuroscience 1994;60(3):621-36.
1994: Wu D; Hersh L B
Choline acetyltransferase: celebrating its fiftieth year.
Journal of neurochemistry 1994;62(5):1653-63.
1994: Miller B C; Thiele D L; Hersh L B; Cottam G L
Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells.
Archives of biochemistry and biophysics 1994;311(1):174-9.
1994: Johnson G D; Hersh L B
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
The Journal of biological chemistry 1994;269(10):7682-8.
1994: Miller B C; Ackroyd A; Hersh L B; Cottam G L
Methionine enkephalin metabolism by murine macrophage ectopeptidase(s).
Regulatory peptides 1994;50(1):87-98.
1994: Quay T; Slaughter C; Davis T P; Merrill B J; Hersh L B
Positional effects in the neprilysin (neutral endopeptidase) reaction.
Archives of biochemistry and biophysics 1994;308(1):133-6.
1993: Inoue H; Baetge E E; Hersh L B
Enhancer containing unusual GC box-like sequences on the human choline acetyltransferase gene.
Brain research. Molecular brain research 1993;20(4):299-304.
1993: Wu D; Schormann N; Lian W; Deisenhofer J; Hersh L B
Expression, purification, and characterization of recombinant Drosophila choline acetyltransferase.
Journal of neurochemistry 1993;61(4):1416-22.
1993: Armstrong D M; Sheffield R; Buzsaki G; Chen K S; Hersh L B; Nearing B; Gage F H
Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats.
Neurobiology of aging 1993;14(5):457-70.
1993: Li Y P; Baskin F; Davis R; Hersh L B
Cholinergic neuron-specific expression of the human choline acetyltransferase gene is controlled by silencer elements.
Journal of neurochemistry 1993;61(2):748-51.
1993: Hersh L B; Kong C F; Sampson C; Mues G; Li Y P; Fisher A; Hilt D; Baetge E E
Comparison of the promoter region of the human and porcine choline acetyltransferase genes: localization of an important enhancer region.
Journal of neurochemistry 1993;61(1):306-14.
1993: Carbini L A; Hersh L B
Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis.
Journal of neurochemistry 1993;61(1):247-53.
1993: Lehéricy S; Hirsch E C; Cervera-Piérot P; Hersh L B; Bakchine S; Piette F; Duyckaerts C; Hauw J J; Javoy-Agid F; Agid Y
Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease.
The Journal of comparative neurology 1993;330(1):15-31.
1993: Li Y P; Baetge E E; Hersh L B
Cyclic AMP regulation of the human choline acetyltransferase gene.
Neurochemical research 1993;18(3):271-5.
1993: de Lacalle S; Hersh L B; Saper C B
Cholinergic innervation of the human cerebellum.
The Journal of comparative neurology 1993;328(3):364-76.
1992: Hersh L B
Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15.
Neurochemical research 1992;17(11):1063-7.
1992: Mesulam M M; Mash D; Hersh L; Bothwell M; Geula C
Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus.
The Journal of comparative neurology 1992;323(2):252-68.
1992: Johnson G D; Hersh L B
Cloning a rat meprin cDNA reveals the enzyme is a heterodimer.
The Journal of biological chemistry 1992;267(19):13505-12.
1992: Iijima H; Gerard N P; Squassoni C; Ewig J; Face D; Drazen J M; Kim Y A; Shriver B; Hersh L B; Gerard C
Exon 16 del: a novel form of human neutral endopeptidase (CALLA).
The American journal of physiology 1992;262(6 Pt 1):L725-9.
1992: Kim Y A; Shriver B; Quay T; Hersh L B
Analysis of the importance of arginine 102 in neutral endopeptidase (enkephalinase) catalysis.
The Journal of biological chemistry 1992;267(17):12330-5.
1992: Gaykema R P; Nyakas C; Horvath E; Hersh L B; Majtenyi C; Luiten P G
Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease.
Neurobiology of aging 1992;13(3):441-8.
1992: Kim Y A; Shriver B; Hersh L B
Mutational analysis reveals only one catalytic histidine in neutral endopeptidase ("enkephalinase").
Biochemical and biophysical research communications 1992;184(2):883-7.
1992: Vida T A; Hersh L B
Glycosylation variants of endopeptidase-24.11 ('enkephalinase').
Neuropeptides 1992;21(4):245-55.
1992: Mesulam M M; Hersh L B; Mash D C; Geula C
Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: a choline acetyltransferase study.
The Journal of comparative neurology 1992;318(3):316-28.
1991: Weber S J; Greene D L; Sharma S D; Yamamura H I; Kramer T H; Burks T F; Hruby V J; Hersh L B; Davis T P
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1109-17.
1991: Casey M L; Smith J W; Nagai K; Hersh L B; MacDonald P C
Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium.
The Journal of biological chemistry 1991;266(34):23041-7.
1991: Shipp M A; Tarr G E; Chen C Y; Switzer S N; Hersh L B; Stein H; Sunday M E; Reinherz E L
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10662-6.
1991: Ibáñez C F; Pelto-Huikko M; Söder O; Ritzèn E M; Hersh L B; Hökfelt T; Persson H
Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3676-80.
1991: Armstrong D M; Brady R; Hersh L B; Hayes R C; Wiley R G
Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneurons following nerve injury.
The Journal of comparative neurology 1991;304(4):596-607.
1991: Strauss W L; Kemper R R; Jayakar P; Kong C F; Hersh L B; Hilt D C; Rabin M
Human choline acetyltransferase gene maps to region 10q11-q22.2 by in situ hybridization.
Genomics 1991;9(2):396-8.
1991: Lehéricy S; Hirsch E C; Hersh L B; Agid Y
Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients.
Neuroscience letters 1991;123(2):152-5.
1991: Fuxe K; Tinner B; Staines W; Hemsén A; Hersh L; Lundberg J M
Demonstration and nature of endothelin-3-like immunoreactivity in somatostatin and choline acetyltransferase-immunoreactive nerve cells of the neostriatum of the rat.
Neuroscience letters 1991;123(1):107-11.
1991: Gaykema R P; van Weeghel R; Hersh L B; Luiten P G
Prefrontal cortical projections to the cholinergic neurons in the basal forebrain.
The Journal of comparative neurology 1991;303(4):563-83.
1991: Juncos J L; Hirsch E C; Malessa S; Duyckaerts C; Hersh L B; Agid Y
Mesencephalic cholinergic nuclei in progressive supranuclear palsy.
Neurology 1991;41(1):25-30.
1991: Hersh L B
Use of site-directed mutagenesis to elucidate the active site of neutral endopeptidase 24.11 (enkephalinase).
NIDA research monograph 1991;111():188-201.
1991: Gaykema R P; Gaál G; Traber J; Hersh L B; Luiten P G
The basal forebrain cholinergic system: efferent and afferent connectivity and long-term effects of lesions.
Acta psychiatrica Scandinavica. Supplementum 1991;366():14-26.
1991: Gaykema R P; van der Kuil J; Hersh L B; Luiten P G
Patterns of direct projections from the hippocampus to the medial septum-diagonal band complex: anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunohistochemistry of choline acetyltransferase.
Neuroscience 1991;43(2-3):349-60.
1990: Kimura H; Tago H; Akiyama H; Hersh L B; Tooyama I; McGeer P L
Choline acetyltransferase immunopositive neurons in the lateral septum.
Brain research 1990;533(1):165-70.
1990: Vijayaraghavan J; Kim Y A; Jackson D; Orlowski M; Hersh L B
Use of site-directed mutagenesis to identify valine-573 in the S'1 binding site of rat neutral endopeptidase 24.11 (enkephalinase).
Biochemistry 1990;29(35):8052-6.
1990: Zoli M; Cintra A; Zini I; Hersh L B; Gustafsson J A; Fuxe K; Agnati L F
Nerve cell clusters in dorsal striatum and nucleus accumbens of the male rat demonstrated by glucocorticoid receptor immunoreactivity.
Journal of chemical neuroanatomy 1990;3(5):355-66.
1990: Vijayaraghavan J; Scicli A G; Carretero O A; Slaughter C; Moomaw C; Hersh L B
The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).
The Journal of biological chemistry 1990;265(24):14150-5.
1990: Bateman R C; Rodriguez G; Vijayaraghavan J; Hersh L B
Effect of electron withdrawing substituents on substrate hydrolysis by and inhibition of rat neutral endopeptidase 24.11 (enkephalinase) and thermolysin.
Archives of biochemistry and biophysics 1990;279(2):355-62.
1990: Brandel J P; Hirsch E C; Hersh L B; Javoy-Agid F
Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain.
Brain research 1990;515(1-2):117-25.
1990: Bateman R C; Kim Y A; Slaughter C; Hersh L B
N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11.
The Journal of biological chemistry 1990;265(15):8365-8.
1990: Wang F Z; Nelson P G; Fitzgerald S C; Hersh L B; Neale E A
Cholinergic function in cultures of mouse spinal cord neurons.
Journal of neuroscience research 1990;25(3):312-23.
1990: Armstrong D M; Manley L; Haycock J W; Hersh L B
Co-localization of choline acetyltransferase and tyrosine hydroxylase within neurons of the dorsal motor nucleus of the vagus.
Journal of chemical neuroanatomy 1990;3(2):133-40.
1990: Geula C; Tokuno H; Hersh L; Mesulam M M
Human striatal cholinergic neurons in development, aging and Alzheimer's disease.
Brain research 1990;508(2):310-2.
1990: Johnson G D; Hersh L B
Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase.
Archives of biochemistry and biophysics 1990;276(2):305-9.
1990: Dyer S H; Slaughter C A; Orth K; Moomaw C R; Hersh L B
Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat.
Journal of neurochemistry 1990;54(2):547-54.
1990: Carbini L; Rodriguez G; Hersh L B
Kinetic and inactivation studies of recombinant Drosophila choline acetyltransferase.
Brain research bulletin 1990;24(1):119-24.
1990: Carpenter M B; Huang Y; Pereira A B; Hersh L B
Immunocytochemical features of the vestibular nuclei in the monkey and cat.
Journal für Hirnforschung 1990;31(5):585-99.
1989: Lehéricy S; Hirsch E C; Cervera P; Hersh L B; Hauw J J; Ruberg M; Agid Y
Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8580-4.
1989: Alderson R F; Hua Z W; Hersh L B
Nerve growth factor and phorbol esters increase the number of choline acetyltransferase-positive cells in two morphologically distinct classes of basal forebrain neurons in primary cultures.
Brain research. Developmental brain research 1989;48(2):229-41.
1989: Tago H; McGeer P L; McGeer E G; Akiyama H; Hersh L B
Distribution of choline acetyltransferase immunopositive structures in the rat brainstem.
Brain research 1989;495(2):271-97.
1989: Mufson E J; Bothwell M; Hersh L B; Kordower J H
Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons.
The Journal of comparative neurology 1989;285(2):196-217.
1989: Bruce G; Hersh L B
The phosphorylation of choline acetyltransferase.
Neurochemical research 1989;14(7):613-20.
1989: Mesulam M M; Geula C; Bothwell M A; Hersh L B
Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons.
The Journal of comparative neurology 1989;283(4):611-33.
1989: Bateman R C; Jackson D; Slaughter C A; Unnithan S; Chai Y G; Moomaw C; Hersh L B
Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.
The Journal of biological chemistry 1989;264(11):6151-7.
1989: Tinner B; Fuxe K; Köhler C; Hersh L; Andersson K; Jansson A; Goldstein M; Agnati L F
Evidence for the existence of a population of arcuate neurons costoring choline acetyltransferase and tyrosine hydroxylase immunoreactivities in the male rat.
Neuroscience letters 1989;99(1-2):44-9.
1989: Kordower J H; Gash D M; Bothwell M; Hersh L; Mufson E J
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients.
Neurobiology of aging 1989;10(1):67-74.
1989: Hirsch E C; Graybiel A M; Hersh L B; Duyckaerts C; Agid Y
Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum.
Neuroscience letters 1989;96(2):145-50.
1989: Shipp M A; Vijayaraghavan J; Schmidt E V; Masteller E L; D'Adamio L; Hersh L B; Reinherz E L
Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):297-301.
1989: Eriksdotter-Nilsson M; Skirboll S; Ebendal T; Hersh L; Grassi J; Massoulié J; Olson L
NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;74(1):89-98.
1989: Lysakowski A; Wainer B H; Bruce G; Hersh L B
An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex.
Neuroscience 1989;28(2):291-336.
1989: Ransmayr G; Cervera P; Hirsch E; Ruberg M; Hersh L B; Duyckaerts C; Hauw J J; Delumeau C; Agid Y
Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease.
Neuroscience 1989;32(3):701-14.
1988: Hersh L B; Takane K; Gylys K; Moomaw C; Slaughter C
Conservation of amino acid sequences between human and porcine choline acetyltransferase.
Journal of neurochemistry 1988;51(6):1843-5.
1988: Mufson E J; Mash D C; Hersh L B
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease.
Annals of neurology 1988;24(5):623-9.
1988: McLellan S; Dyer S H; Rodriguez G; Hersh L B
Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases.
Journal of neurochemistry 1988;51(5):1552-9.
1988: Armstrong D M; Rotler A; Hersh L B; Pickel V M
Localization of choline acetyltransferase in perikarya and dendrites within the nuclei of the solitary tracts.
Journal of neuroscience research 1988;20(3):279-90.
1988: Armstrong D M; Hersh L B; Gage F H
Morphologic alterations of cholinergic processes in the neocortex of aged rats.
Neurobiology of aging 1988;9(2):199-205.
1988: Mariani A P; Hersh L B
Synaptic organization of cholinergic amacrine cells in the rhesus monkey retina.
The Journal of comparative neurology 1988;267(2):269-80.
1987: Armstrong D M; Bruce G; Hersh L B; Gage F H
Development of cholinergic neurons in the septal/diagonal band complex of the rat.
Brain research 1987;433(2):249-56.
1987: Okoyama S; Tago H; McGeer P L; Hersh L B; Kimura H
Cholinergic divergent projections from rat basal forebrain to the hippocampus and olfactory bulb.
Neuroscience letters 1987;83(1-2):77-81.
1987: Bruce G; Hersh L B
Studies on detergent released choline acetyltransferase from membrane fractions of rat and human brain.
Neurochemical research 1987;12(12):1059-66.
1987: Armstrong D M; Terry R D; Deteresa R M; Bruce G; Hersh L B; Gage F H
Response of septal cholinergic neurons to axotomy.
The Journal of comparative neurology 1987;264(3):421-36.
1987: Bateman R C; Hersh L B
Mechanism based design of inhibitors of neuropeptide degrading enzymes.
Drug design and delivery 1987;2(1):55-68.
1987: Carpenter M B; Chang L; Pereira A B; Hersh L B
Comparisons of the immunocytochemical localization of choline acetyltransferase in the vestibular nuclei of the monkey and rat.
Brain research 1987;418(2):403-8.
1987: Bateman R C; Hersh L B
Evidence for an essential histidine in neutral endopeptidase 24.11.
Biochemistry 1987;26(14):4237-42.
1987: Tago H; McGeer P L; Bruce G; Hersh L B
Distribution of choline acetyltransferase-containing neurons of the hypothalamus.
Brain research 1987;415(1):49-62.
1987: Hersh L B; Aboukhair N; Watson S
Immunohistochemical localization of aminopeptidase M in rat brain and periphery: relationship of enzyme localization and enkephalin metabolism.
Peptides 1987;8(3):523-32.
1987: Carpenter M B; Chang L; Pereira A B; Hersh L B; Bruce G; Wu J Y
Vestibular and cochlear efferent neurons in the monkey identified by immunocytochemical methods.
Brain research 1987;408(1-2):275-80.
1987: Shiromani P J; Armstrong D M; Bruce G; Hersh L B; Groves P M; Gillin J C
Relation of pontine choline acetyltransferase immunoreactive neurons with cells which increase discharge during REM sleep.
Brain research bulletin 1987;18(3):447-55.
1986: Armstrong D M; Bruce G; Hersh L B; Terry R D
Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain.
Neuroscience letters 1986;71(2):229-34.
1986: Jackson D G; Hersh L B
Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents.
The Journal of biological chemistry 1986;261(19):8649-54.
1986: Hersh L B; Morihara K
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin.
The Journal of biological chemistry 1986;261(14):6433-7.
1986: Hersh L B
Nomenclature for enkephalin degrading peptidases.
Life sciences 1986;38(13):1151-3.
1986: Lysakowski A; Wainer B H; Rye D B; Bruce G; Hersh L B
Cholinergic innervation displays strikingly different laminar preferences in several cortical areas.
Neuroscience letters 1986;64(1):102-8.
1985: German D C; Bruce G; Hersh L B
Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase.
Neuroscience letters 1985;61(1-2):1-5.
1985: Ojeda S R; Costa M E; Katz K H; Hersh L B
Evidence for the existence of substance P in the prepubertal rat ovary. I. Biochemical and physiologic studies.
Biology of reproduction 1985;33(2):286-95.
1985: Bruce G; Wainer B H; Hersh L B
Immunoaffinity purification of human choline acetyltransferase: comparison of the brain and placental enzymes.
Journal of neurochemistry 1985;45(2):611-20.
1985: Hersh L B
Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase.
Journal of neurochemistry 1985;44(5):1427-35.
1985: Ulrich C; Hersh L B
Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases.
Peptides 1985;6(3):475-82.
1985: Hersh L B
N-Methyl-L-glutamate synthase.
Methods in enzymology 1985;113():36-42.
1984: Hersh L B
Reaction of opioid peptides with neutral endopeptidase ("enkephalinase").
Journal of neurochemistry 1984;43(2):487-93.
1984: Rush R S; Mitas M; Powers J C; Tanaka T; Hersh L B
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase).
Archives of biochemistry and biophysics 1984;231(2):390-9.
1984: Hersh L B; Wainer B H; Andrews L P
Multiple isoelectric and molecular weight variants of choline acetyltransferase. Artifact or real?
The Journal of biological chemistry 1984;259(2):1253-8.
1983: Gafford J T; Skidgel R A; Erdös E G; Hersh L B
Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides.
Biochemistry 1983;22(13):3265-71.
1983: Hersh L B; Gafford J T; Powers J C; Tanaka T; Erdös E G
Novel substrates for angiotensin I converting enzyme.
Biochemical and biophysical research communications 1983;110(2):654-9.
1982: Hersh L B
Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium.
The Journal of biological chemistry 1982;257(21):12820-5.
1982: Hersh L B; Surendranathan K K
Reaction of malate thiokinase with methoxycarbonyl-CoA disulfide. Evidence for half-of-the-sites reactivity.
The Journal of biological chemistry 1982;257(19):11633-8.
1982: Rush R S; Hersh L B
Multiple molecular forms of rat brain enkephalinase.
Life sciences 1982;31(5):445-51.
1982: Hersh L B
Degradation of enkephalins: the search for an enkephalinase.
Molecular and cellular biochemistry 1982;47(1):35-43.
1981: Hersh L B
Immunological, physical, and chemical evidence for the identity of brain and kidney post-proline cleaving-enzyme.
Journal of neurochemistry 1981;37(1):172-8.
1981: Hersh L B
Inhibition of aminopeptidase and acetylcholinesterase by puromycin and puromycin analogs.
Journal of neurochemistry 1981;36(4):1594-6.
1981: Hersh L B
Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin.
Biochemistry 1981;20(8):2345-50.
1981: Hersh L B; Peet M
Half-of-the-sites reactivity in the malate thiokinase reaction.
The Journal of biological chemistry 1981;256(4):1732-7.
1981: Hersh L B; McKelvy J F
An aminopeptidase from bovine brain which catalyzes the hydrolysis of enkephalin.
Journal of neurochemistry 1981;36(1):171-8.
1981: Hersh L B; Smith D J
Methoxycarbonyl-CoA disulfide: an active site-directed sulfhydryl reagent.
Methods in enzymology 1981;72():584-7.
1980: Hersh L B; Smith T E; McKelvy J F
Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase.
Nature 1980;286(5769):160-2.
1980: Blumberg S; Teichberg V I; Charli J L; Hersh L B; McKelvy J F
Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline Cleaving enzyme from bovine brain.
Brain research 1980;192(2):477-86.
1980: Hersh L B
Studies on the kinetic mechanism and salt activation of bovine brain choline acetyltransferase.
Journal of neurochemistry 1980;34(5):1077-81.
1980: Hersh L B; Walsh C
Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD.
Methods in enzymology 1980;66():277-87.
1979: Hersh L B; Nair R V; Smith D J
The reaction of choline acetyltransferase with sulfhydryl reagents. Methoxycarbonyl-CoA disulfide as an active site-directed reagent.
The Journal of biological chemistry 1979;254(23):11988-92.
1979: Hersh L B; McKelvy J F
Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain.
Brain research 1979;168(3):553-64.
1979: Elwell M; Hersh L B
Substrate-dependent dissociation of malate thiokinase.
The Journal of biological chemistry 1979;254(7):2434-8.
1979: Hersh L B
The lack of specificity towards salts in the activation of choline acetyltransferase from human placenta.
Journal of neurochemistry 1979;32(3):991-6.
1978: Hersh L B; Barker L A; Rush B
Effect of sodium chloride on changing the rate-limiting step in the human placental choline acetyltransferase reaction.
The Journal of biological chemistry 1978;253(14):4966-70.
1978: Hersh L B; Coe B; Casey L
A fluorometric assay for choline acetyltransferase and its use in the purification of the enzyme from human placenta.
Journal of neurochemistry 1978;30(5):1077-85.
1978: Hersh L B; Peet M
Effect of salts on the physical and kinetic properties of human placental choline acetyltransferase.
Journal of neurochemistry 1978;30(5):1087-93.
1978: Millay R H; Schilling H; Hersh L B
The reduced nicotinamide adenine nucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Further studies on regulatory properties.
The Journal of biological chemistry 1978;253(5):1371-7.
1977: Hersh L B; Peet M
Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction.
The Journal of biological chemistry 1977;252(14):4796-802.
1977: Willerson J T; Stone M J; Ting R; Mukherjee A; Gomez-Sanchez C E; Lewis P; Hersh L B
Radioimmunoassay of creatine kinase-B isoenzyme in human sera: results in patients with acute myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(4):1711-5.
1976: Jorns M S; Hersh L B
Nucleophilic addition reactions of free and enzyme-bound deazaflavin.
The Journal of biological chemistry 1976;251(16):4872-81.
1976: Millay R H; Hersh L B
The reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Correlation of allosteric properties with changes in the sedimentation behavior.
The Journal of biological chemistry 1976;251(9):2754-60.
1976: Hersh L B; Jorns M S; Petterson J; Curie M
Letter: The formation of a semiquinone form of deazaFAD bound to D-amino acid oxidase.
Journal of the American Chemical Society 1976;98(3):865-7.
1975: Newaz S S; Hersh L B
Reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase in Pseudomonas MA: potential regulation between carbon assimilation and energy production.
Journal of bacteriology 1975;124(2):825-33.
1975: Hersh L B; Jorns M S
Use of 5-deazaFAD to study hydrogen transfer in the D-amino acid oxidase reaction.
The Journal of biological chemistry 1975;250(22):8728-34.
1975: Jorns M S; Hersh L B
N-Methylglutamate synthetase. Substrate-flavin hydrogen transfer reactions probed with deazaflavin mononucleotide.
The Journal of biological chemistry 1975;250(10):3620-8.
1974: Frenkel E P; Kitchens R L; Hersh L B; Frenkel R
Effect of vitamin B12 deprivation on the in vivo levels of coenzyme A intermediates associated with propionate metabolism.
The Journal of biological chemistry 1974;249(21):6984-91.
1974: Hersh L B
Malate thiokinase. The reaction mechanism as determined by initial rate studies.
The Journal of biological chemistry 1974;249(19):6264-71.
1974: Hersh L B
Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis.
The Journal of biological chemistry 1974;249(16):5208-12.
1974: Jorns M S; Hersh L B
Demonstration of enzymic hydrogen transfer from substrate to a flavine.
Journal of the American Chemical Society 1974;96(12):4012-4.
1974: Hersh L B; Raj P P; Ohlweiler D
Kinetics of succinyldithiocholine hydrolysis by serum cholinesterase: comparison to dibucaine and succinylcholine numbers.
The Journal of pharmacology and experimental therapeutics 1974;189(2):544-9.
1973: Hersh L B
Malate adenosine triphosphate lyase. Separation of the reaction into a malate thiokinase and malyl coenzyme A lyase.
The Journal of biological chemistry 1973;248(21):7295-303.
1973: Pollock R J; Hersh L B
N-methylglutamate synthetase. The use of flavin mononucleotide in oxidative catalysis.
The Journal of biological chemistry 1973;248(19):6724-33.
1972: Bellion E; Hersh L B
Methylamine metabolism in a pseudomonas species.
Archives of biochemistry and biophysics 1972;153(1):368-74.
1972: Hersh L B; Bellion E
Malate cleavage reaction in Pseudomonas species, (Shaw strain MA).
Biochemical and biophysical research communications 1972;48(3):712-9.
1972: Hersh L B
Rat liver -amidase. Kinetic evidence for an acyl-enzyme intermediate.
Biochemistry 1972;11(12):2251-6.
1972: Hersh L B; Stark M J; Worthen S; Fiero M K
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme.
Archives of biochemistry and biophysics 1972;150(1):219-26.
1971: Hersh L B
The effect of aliphatic alcohols and organic solvents on reactions catalyzed by 5-hydroxy-N-methylpyroglutamate synthetase.
The Journal of biological chemistry 1971;246(24):7804-9.
1971: Hersh L B
5-Hydroxy-N-methylpyroglutamate synthetase. Evidence for an -ketoglutaryl enzyme intermediate from partitioning studies.
The Journal of biological chemistry 1971;246(22):6803-6.
1971: Pollock R J; Hersh L B
N-methylglutamate synthetase. Purification and properties of the enzyme.
The Journal of biological chemistry 1971;246(15):4737-43.
1971: Hersh L B
Rat liver omega-amidase. Purification and properties.
Biochemistry 1971;10(15):2884-91.
1971: Hersh L B; Peterson J A; Thompson A A
An N-methyl glutamate dehydrogenase from Pseudomonas M.A.
Archives of biochemistry and biophysics 1971;145(1):115-20.
1970: Hersh L B; Srere P A
A continuous spectrophotometric method for ammonia-generating reactions.
Analytical biochemistry 1970;37(2):353-6.
1970: Hersh L B
5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action.
The Journal of biological chemistry 1970;245(14):3526-35.
1969: Hersh L B; Tsai L; Stadtman E R
The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid.
The Journal of biological chemistry 1969;244(17):4677-83.
1967: Hersh L B; Jencks W P
Isolation of an enzyme-coenzyme A intermediate from succinyl coenzyme A-acetoacetate coenzyme A transferase.
The Journal of biological chemistry 1967;242(2):339-40.

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