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Pamela Hershberger

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Qiuhong Zhang; Jan Beumer; Shama Buch; Brenda Diergaarde; Beatriz Kanterewicz; Yan Lin; Robert Parise; Martin Petkovich; Pamela A Hershberger
CYP24 inhibition preserves 1α,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells.
Jan H Beumer; David Z D'Argenio; Beatriz Kanterewicz; Robert A Parise; Martin Petkovich; Pamela A Hershberger
A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.
Jan H Beumer; Julie L Eiseman; Judith A Gilbert; Julianne L Holleran; Archibong E Yellow-Duke; Dana M Clausen; David Z D'Argenio; Matthew M Ames; Pamela A Hershberger; Robert A Parise; Lihua Bai; Joseph M Covey; Merrill J Egorin
Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.

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All Publications

2012: Qiuhong Zhang; Jan Beumer; Shama Buch; Brenda Diergaarde; Beatriz Kanterewicz; Yan Lin; Robert Parise; Martin Petkovich; Pamela A Hershberger
CYP24 inhibition preserves 1α,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells.
Molecular and cellular endocrinology 2012;355(1):153-61.
2012: Jan H Beumer; David Z D'Argenio; Beatriz Kanterewicz; Robert A Parise; Martin Petkovich; Pamela A Hershberger
A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.
Steroids 2012;77(5):477-83.
2011: Jan H Beumer; Julie L Eiseman; Judith A Gilbert; Julianne L Holleran; Archibong E Yellow-Duke; Dana M Clausen; David Z D'Argenio; Matthew M Ames; Pamela A Hershberger; Robert A Parise; Lihua Bai; Joseph M Covey; Merrill J Egorin
Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.
Cancer chemotherapy and pharmacology 2011;67(2):421-30.
2011: Malini Srinivasan; Anil V Parwani; Pamela A Hershberger; Diana E Lenzner; Joel L Weissfeld
Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer.
The Journal of steroid biochemistry and molecular biology 2011;123(1-2):30-6.
2010: Mark Nichols; Peng Cheng; Yue Liu; Beatriz Kanterewicz; Pamela A Hershberger; Kenneth S McCarty
Breast cancer-derived M543V mutation in helix 12 of estrogen receptor alpha inverts response to estrogen and SERMs.
Breast cancer research and treatment 2010;120(3):761-8.
2010: Taofeek K Owonikoko; Suresh S Ramalingam; Beatriz Kanterewicz; Trent E Balius; Chandra P Belani; Pamela A Hershberger
Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells.
International journal of cancer. Journal international du cancer 2010;126(3):743-55.
2009: Jill M Siegfried; Pamela A Hershberger; Laura P Stabile
Estrogen receptor signaling in lung cancer.
Seminars in oncology 2009;36(6):524-31.
2009: Pamela A Hershberger; Laura P Stabile; Beatriz Kanterewicz; Mary E Rothstein; Christopher T Gubish; Stephanie Land; Yongli Shuai; Jill M Siegfried; Mark Nichols
Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-small cell lung cancer cells.
The Journal of steroid biochemistry and molecular biology 2009;116(1-2):102-9.
2008: Yingyu Ma; Wei-Dong Yu; Pamela A Hershberger; Geraldine Flynn; Rui-Xian Kong; Donald L Trump; Candace S Johnson
1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model.
Molecular cancer therapeutics 2008;7(9):3047-55.
2006: Robert A Parise; Merrill J Egorin; Beatriz Kanterewicz; Mohammed Taimi; Martin Petkovich; April M Lew; Samuel S Chuang; Mark Nichols; Talal El-Hefnawy; Pamela A Hershberger
CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer.
International journal of cancer. Journal international du cancer 2006;119(8):1819-28.
2006: Candace S Johnson; Josephia R Muindi; Pamela A Hershberger; Donald L Trump
The antitumor efficacy of calcitriol: preclinical studies.
Anticancer research 2006;26(4A):2543-9.
2005: Pamela A Hershberger; A Cecilia Vasquez; Beatriz Kanterewicz; Stephanie Land; Jill M Siegfried; Mark Nichols
Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.
Cancer research 2005;65(4):1598-605.
2004: Peng Cheng; Beatriz Kanterewicz; Pamela A Hershberger; Kenneth S McCarty; Billy W Day; Mark Nichols
Inhibition of estrogen receptor alpha-mediated transcription by antiestrogenic 1,1-dichloro-2,2,3-triarylcyclopropanes.
Molecular pharmacology 2004;66(4):970-7.
2004: Donald L Trump; Pamela A Hershberger; Ronald J Bernardi; Sharmilla Ahmed; Josephia R Muindi; Marwan G Fakih; Wei-Dong Yu; Candace S Johnson
Anti-tumor activity of calcitriol: pre-clinical and clinical studies.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):519-26.
2003: Sanjay Srivastava; Dong Xiao; Karen L Lew; Pamela A Hershberger; Demetrius M Kokkinakis; Candace S Johnson; Donald L Trump; Shivendra V Singh
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.
Carcinogenesis 2003;24(10):1665-70.
2003: Masatoshi Eto; Jaafar Bennouna; Oriana C Hunter; Pamela A Hershberger; Tatsuya Kanto; Candace S Johnson; Michael T Lotze; Andrew A Amoscato
C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells.
The Prostate 2003;57(1):66-79.
2003: Dong Xiao; Sanjay Srivastava; Karen L Lew; Yan Zeng; Pamela A Hershberger; Candace S Johnson; Donald L Trump; Shivendra V Singh
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis.
Carcinogenesis 2003;24(5):891-7.
2002: Josephia R Muindi; Yibing Peng; Douglas M Potter; Pamela A Hershberger; Jil S Tauch; Mary Jo Capozzoli; Merrill J Egorin; Candace S Johnson; Donald L Trump
Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel.
Clinical pharmacology and therapeutics 2002;72(6):648-59.
2002: Candace S Johnson; Pamela A Hershberger; Ronald J Bernardi; Terence F Mcguire; Donald L Trump
Vitamin D receptor: a potential target for intervention.
Urology 2002;60(3 Suppl 1):123-30; discussion 130-1.
2002: Pamela A Hershberger; Terence F Mcguire; Wei-Dong Yu; Eleanor G Zuhowski; Jan H M Schellens; Merrill J Egorin; Donald L Trump; Candace S Johnson
Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression.
Molecular cancer therapeutics 2002;1(10):821-9.
2001: Ronald J Bernardi; Donald L Trump; Wei-Dong Yu; Terence F Mcguire; Pamela A Hershberger; Candace S Johnson
Combination of 1alpha,25-dihydroxyvitamin D(3) with dexamethasone enhances cell cycle arrest and apoptosis: role of nuclear receptor cross-talk and Erk/Akt signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4164-73.
2001: Pamela A Hershberger; Wei-Dong Yu; Ruth A Modzelewski; Robert M Rueger; Candace S Johnson; Donald L Trump
Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):1043-51.
2001: Badrinath R Konety; John Lavelle; G Pirtskalaishvili; Rajiv Dhir; Susan A Meyers; TS Nguyen; Pamela A Hershberger; Michael R Shurin; Candace S Johnson; Donald L Trump; Mark L Zeidel; Robert H Getzenberg
Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo.
The Journal of urology 2001;165(1):253-8.
1999: Pamela A Hershberger; Ruth A Modzelewski; Z R Shurin; Robert M Rueger; Donald L Trump; Candace S Johnson
1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo.
Cancer research 1999;59(11):2644-9.
1998: H He; Pamela A Hershberger; Susan A McCarthy
Down-modulation of a novel Bax-associated protein during apoptosis in normal mature B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1176-82.
1998: H He; Pamela A Hershberger; Susan A McCarthy
Characterization of a novel Bax-associated protein expressed in hemopoietic tissues and regulated during thymocyte apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1169-75.
1998: Pamela A Hershberger; H He; Susan A McCarthy
In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis.
Cellular immunology 1998;185(2):134-45.
1997: Lina Lu; Shiguang Qian; Pamela A Hershberger; William A Rudert; DH Lynch; Angus W Thomson
Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5676-84.
1997: Lina Lu; Shiguang Qian; Pamela A Hershberger; William A Rudert; Y Li; FG Chambers; Thomas E Starzl; DH Lynch; Angus W Thomson
Blocking of the B7-CD28 pathway increases apoptosis induced in activated T cells by in vitro-generated CD95L (FasL) positive dendritic cells.
Transplantation proceedings 1997;29(1-2):1094-5.