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Chaim Hershko

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All Publications

2010: Chaim Hershko
Pathogenesis and management of iron toxicity in thalassemia.
Annals of the New York Academy of Sciences 2010;1202():1-9.
2009: Chaim Hershko; Barry Skikne
Pathogenesis and management of iron deficiency anemia: emerging role of celiac disease, helicobacter pylori, and autoimmune gastritis.
Seminars in hematology 2009;46(4):339-50.
2009: Chaim Hershko
Iron overload in Asia.
Blood 2009;114(1):1-2.
2009: Chaim Hershko; Aharon Ronson
Iron deficiency, Helicobacter infection and gastritis.
Acta haematologica 2009;122(2-3):97-102.
2007: Chaim Hershko
Mechanism of iron toxicity.
Food and nutrition bulletin 2007;28(4 Suppl):S500-9.
2007: Chaim Hershko
Iron loading and its clinical implications.
American journal of hematology 2007;82(12 Suppl):1147-8.
2007: Chaim Hershko; Julian Patz; Aharon Ronson
The anemia of achylia gastrica revisited.
Blood cells, molecules & diseases 2007;39(2):178-83.
2007: Chaim Hershko; Mara Ianculovich; Moshe Souroujon
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.
Acta haematologica 2007;118(1):19-26.
2007: Chaim Hershko; Mara Ianculovich; Moshe Souroujon
A hematologist's view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication.
Blood cells, molecules & diseases 2007;38(1):45-53.
2006: Hava Glickstein; Rinat Ben El; Gabriela Link; William Breuer; Abraham M Konijn; Chaim Hershko; Hanspeter Nick; Ioav Cabantchik
Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences.
Blood 2006;108(9):3195-203.
2006: Chaim Hershko; Aharon Ronson; Moshe Souroujon; Itzhak Maschler; Judith Heyd; Julian Patz
Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion.
Blood 2006;107(4):1673-9.
2005: Chaim Hershko
[Lead poisoning by contaminated flour: an unfinished story].
Harefuah 2005;144(7):458-62, 528.
2005: Chaim Hershko; Amnon Lahad; Dan Kereth
Gastropathic sideropenia.
Best practice & research. Clinical haematology 2005;18(2):363-80.
2005: Chaim Hershko; A Victor Hoffbrand; Dan Keret; Moshe Souroujon; Itzhak Maschler; Yehudit Monselise; Amnon Lahad
Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia.
Haematologica 2005;90(5):585-95.
2005: Chaim Hershko; Gabriela Link; Abraham M Konijn; Ioav Cabantchik
Iron chelation therapy.
Current hematology reports 2005;4(2):110-6.
2005: Chaim Hershko; Gabriela Link; Abraham M Konijn; Ioav Cabantchik
Objectives and mechanism of iron chelation therapy.
Annals of the New York Academy of Sciences 2005;1054():124-35.
2005: Chaim Hershko; Gabriela Link; Abraham M Konijn; Z Ioav Cabantchik
Iron overload and chelation.
Hematology (Amsterdam, Netherlands) 2005;10 Suppl 1():171-3.
2004: Pensri Pootrakul; William Breuer; Matias Sametband; Pornpan Sirankapracha; Chaim Hershko; Ioav Cabantchik
Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator.
Blood 2004;104(5):1504-10.
2004: Michal Mates; Gideon Nesher; Batia Roth; Rina Rosenberg; Judith Heyd; Chaim Hershko
Transient severe eosinophilia precipitating massive venous thrombosis in a patient with hereditary thrombophilia.
Acta haematologica 2004;112(4):209-11.
2004: Anat Gafter-Gvili; Miron Prokocimer; William Breuer; Ioav Zeev Cabantchik; Chaim Hershko
Non-transferrin-bound serum iron (NTBI) in megaloblastic anemia: effect of vitamin B(12) treatment.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(1):32-4.
2003: Breno P Esposito; William Breuer; Pornpan Sirankapracha; Pensri Pootrakul; Chaim Hershko; Ioav Cabantchik
Labile plasma iron in iron overload: redox activity and susceptibility to chelation.
Blood 2003;102(7):2670-7.
2003: A Victor Hoffbrand; Alan Cohen; Chaim Hershko
Role of deferiprone in chelation therapy for transfusional iron overload.
Blood 2003;102(1):17-24.
2003: Gabriela Link; Prem Ponka; Abraham M Konijn; William Breuer; Ioav Cabantchik; Chaim Hershko
Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells.
Blood 2003;101(10):4172-9.
2003: Chaim Hershko; Aya Abrahamov; Abraham M Konijn; William Breuer; Ioav Zeev Cabantchik; Pensri Pootrakul; Gabriela Link
Objectives and methods of iron chelation therapy.
Bioinorganic chemistry and applications 2003;():151-68.
2002: Chaim Hershko; Gabriela Link; Abraham M Konijn
Cardioprotective effect of iron chelators.
Advances in experimental medicine and biology 2002;509():77-89.
2002: Anat Gafter-Gvili; Miron Prokocimer; William Breuer; Ioav Zeev Cabantchik; Chaim Hershko
Increased non-transferrin-bound serum iron in megaloblastic anaemia.
Acta haematologica 2002;108(1):53-4.
2002: Chaim Hershko; Gabriela Link; Abraham M Konijn; M Huerta; Eliezer Rosenmann; Constantin Reinus
The iron-loaded gerbil model revisited: effects of deferoxamine and deferiprone treatment.
The Journal of laboratory and clinical medicine 2002;139(1):50-8.
2001: Gabriela Link; Abraham M Konijn; William Breuer; Ioav Cabantchik; Chaim Hershko
Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture.
The Journal of laboratory and clinical medicine 2001;138(2):130-8.
2001: Chaim Hershko; Abraham M Konijn; H P Nick; William Breuer; Ioav Cabantchik; Gabriela Link
ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture.
Blood 2001;97(4):1115-22.
2001: William Breuer; M J Ermers; Pensri Pootrakul; A Abramov; Chaim Hershko; Ioav Cabantchik
Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy.
Blood 2001;97(3):792-8.
2000: William Breuer; M J Ermers; Pensri Pootrakul; A Abramov; Chaim Hershko; Ioav Cabantchik
Desferrioxamine-chelatable iron (DCI), a component of serum non-transferrin-bound iron (NTBI) used for assessing iron chelation therapy.
Transfusion science 2000;23(3):241-2.
2000: William Breuer; Chaim Hershko; Ioav Cabantchik
The importance of non-transferrin bound iron in disorders of iron metabolism.
Transfusion science 2000;23(3):185-92.
2000: E Richter; N El-Sharif; A Fischbein; Abraham M Konijn; Raphael Gorodetsky; H El-Sharif; B Kaul; Chaim Hershko; F Grauer; H Foner; A Al-Baba; Z Dweik; M Lihsounat
Re-emergence of lead poisoning from contaminated flour in a West Bank Palestinian village.
International journal of occupational and environmental health 2000;6(3):183-6.
2000: William Breuer; Aharon Ronson; Itzchak Slotki; A Abramov; Chaim Hershko; Ioav Cabantchik
The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation.
Blood 2000;95(9):2975-82.
1999: Esther G Meyron-Holtz; Boris Vaisman; Ioav Cabantchik; Eitan Fibach; Tracey A Rouault; Chaim Hershko; Abraham M Konijn
Regulation of intracellular iron metabolism in human erythroid precursors by internalized extracellular ferritin.
Blood 1999;94(9):3205-11.
1999: Gabriela Link; Abraham M Konijn; Chaim Hershko
Cardioprotective effect of alpha-tocopherol, ascorbate, deferoxamine, and deferiprone: mitochondrial function in cultured, iron-loaded heart cells.
The Journal of laboratory and clinical medicine 1999;133(2):179-88.
1998: Chaim Hershko; Gabriela Link; Ioav Zeev Cabantchik
Pathophysiology of iron overload.
Annals of the New York Academy of Sciences 1998;850():191-201.
1998: Chaim Hershko; Abraham M Konijn; Gabriela Link
Iron chelators for thalassaemia.
British journal of haematology 1998;101(3):399-406.
1998: Gabriela Link; Ann Saada (Reisch); A Pinson; Abraham M Konijn; Chaim Hershko
Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells.
The Journal of laboratory and clinical medicine 1998;131(5):466-74.
1997: G Rivkin; Gabriela Link; E Simhon; R L Cyjon; J Y Klein; Chaim Hershko
IRC011, a new synthetic chelator with selective interaction with catabolic red blood cell iron: evaluation in hypertransfused rats with hepatocellular and reticuloendothelial radioiron probes and in iron-loaded rat heart cells in culture.
Blood 1997;90(10):4180-7.
1997: I Halili-Rutman; Chaim Hershko; Gabriela Link; A J Rutman; Asher Shainberg
Inhibition of calcium accumulation by the sarcoplasmic reticulum: a putative mechanism for the cardiotoxicity of adriamycin.
Biochemical pharmacology 1997;54(1):211-4.
1996: Gabriela Link; R Tirosh; A Pinson; Chaim Hershko
Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction.
The Journal of laboratory and clinical medicine 1996;127(3):272-8.
1996: Chaim Hershko; A Pinson; Gabriela Link
Prevention of anthracycline cardiotoxicity by iron chelation.
Acta haematologica 1996;95(1):87-92.
1995: M Mates; J Heyd; M Souroujon; A Ben Sasson; N Manny; Chaim Hershko
The haematologist as watchdog of community health by full blood count.
QJM : monthly journal of the Association of Physicians 1995;88(5):333-9.
1994: Chaim Hershko
Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators.
Baillière's clinical haematology 1994;7(4):965-1000.
1994: Chaim Hershko; Z I Cabantchik
Control of malaria by drug-mediated iron deprivation.
Israel journal of medical sciences 1994;30(11):840-5.
1994: Gabriela Link; A Pinson; Chaim Hershko
Ability of the orally effective iron chelators dimethyl- and diethyl-hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells.
Blood 1994;83(9):2692-7.
1994: D Meerkin; Y Ashkenazi; S Gottschalk-Sabag; Chaim Hershko
Plasma cell dyscrasia with marrow fibrosis. A reversible syndrome mimicking agnogenic myeloid metaplasia.
Cancer 1994;73(3):625-8.
1994: Gabriela Link; A Pinson; Chaim Hershko
Identification of thiolic sarcolemmal proteins as a primary target of iron toxicity in cultured heart cells.
Advances in experimental medicine and biology 1994;356():267-76.
1993: Chaim Hershko; Gabriela Link; M Tzahor; A Pinson
The role of iron and iron chelators in anthracycline cardiotoxicity.
Leukemia & lymphoma 1993;11(3-4):207-14.
1993: Chaim Hershko; Gabriela Link; M Tzahor; J P Kaltwasser; Pierre Athias; Alain Grynberg; A Pinson
Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture.
The Journal of laboratory and clinical medicine 1993;122(3):245-51.
1993: Amos M Yinnon; G A Morali; Avner Tzvi Goren; Bernard Rudensky; M Isacsohn; J Michel; Chaim Hershko
Effect of age and duration of disease on the clinical manifestations of brucellosis. A study of 73 consecutive patients in Israel.
Israel journal of medical sciences 1993;29(1):11-6.
1993: Gabriela Link; A Pinson; Chaim Hershko
Iron loading of cultured cardiac myocytes modifies sarcolemmal structure and increases lysosomal fragility.
The Journal of laboratory and clinical medicine 1993;121(1):127-34.
1992: Chaim Hershko; Victor Roland Gordeuk; PE Thuma; E N Theanacho; D T Spira; R C Hider; T E Peto; Gary Brittenham
The antimalarial effect of iron chelators: studies in animal models and in humans with mild falciparum malaria.
Journal of inorganic biochemistry 1992;47(3-4):267-77.
1992: S Zevin; Gabriela Link; R W Grady; R C Hider; H H Peter; Chaim Hershko
Origin and fate of iron mobilized by the 3-hydroxypyridin-4-one oral chelators: studies in hypertransfused rats by selective radioiron probes of reticuloendothelial and hepatocellular iron stores.
Blood 1992;79(1):248-53.
1992: Chaim Hershko
Iron chelators in medicine.
Molecular aspects of medicine 1992;13(2):113-65.
1991: Gabriela Link; Pierre Athias; Alain Grynberg; Chaim Hershko; A Pinson
Iron loading modifies beta-adrenergic responsiveness in cultured ventricular myocytes.
Cardioscience 1991;2(3):185-8.
1991: Chaim Hershko; Gabriela Link; A Pinson; H H Peter; P Dobbin; R C Hider
Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture.
Blood 1991;77(9):2049-53.
1991: Chaim Hershko; E N Theanacho; D T Spira; H H Peter; P Dobbin; R C Hider
The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyridin-4-one oral iron chelators.
Blood 1991;77(3):637-43.
1990: Chaim Hershko; M Sonnenblick; J Ashkenazi
Control of steroid-resistant autoimmune haemolytic anaemia by cyclosporine.
British journal of haematology 1990;76(3):436-7.
1990: Chaim Hershko; Gabriela Link; A Pinson
Principles of iron chelating therapy.
Seminars in hematology 1990;27(2):91-4.
1990: Chaim Hershko; A Pinson; Gabriela Link
Iron chelation.
Blood reviews 1990;4(1):1-8.
1990: Chaim Hershko; Gabriela Link; A Pinson; S Avramovici-Grisaru; S Sarel; H H Peter; R C Hider; R W Grady
New orally effective iron chelators. Animal studies.
Annals of the New York Academy of Sciences 1990;612():351-60.
1989: Amos M Yinnon; E N Theanacho; R W Grady; D T Spira; Chaim Hershko
Antimalarial effect of HBED and other phenolic and catecholic iron chelators.
Blood 1989;74(6):2166-71.
1989: Chaim Hershko
Mechanism of iron toxicity and its possible role in red cell membrane damage.
Seminars in hematology 1989;26(4):277-85.
1989: Gabriela Link; A Pinson; I Kahane; Chaim Hershko
Iron loading modifies the fatty acid composition of cultured rat myocardial cells and liposomal vesicles: effect of ascorbate and alpha-tocopherol on myocardial lipid peroxidation.
The Journal of laboratory and clinical medicine 1989;114(3):243-9.
1989: N Hiller; Moshe Sonnenblick; Chaim Hershko
Paraneoplastic hypercalcemia in endometrial carcinoma.
Oncology 1989;46(1):45-8.
1989: Gabriela Link; Pierre Athias; Alain Grynberg; A Pinson; Chaim Hershko
Effect of iron loading on transmembrane potential, contraction, and automaticity of rat ventricular muscle cells in culture.
The Journal of laboratory and clinical medicine 1989;113(1):103-11.
1989: Chaim Hershko; A Eisenberg; A Avni; F Grauer; C Acker; M Hamdallah; S Shahin; J Moreb; E Richter; E Weissenberg
Lead poisoning by contaminated flour.
Reviews on environmental health 1989;8(1-4):17-23.
1988: Amos M Yinnon; A M Konijn; Gabriela Link; J Moreb; Chaim Hershko
Diagnostic value of ferritin in malignant pleural and peritoneal effusions.
Cancer 1988;62(12):2564-8.
1988: Chaim Hershko; T E Peto; D J Weatherall
Iron and infection.
British medical journal (Clinical research ed.) 1988;296(6623):660-4.
1988: Amos M Yinnon; J Kopolovic; L Dollberg; Chaim Hershko
Evolution of malignant lymphoma in agnogenic myeloid metaplasia.
Oncology 1988;45(5):373-7.
1988: G Nesher; A Zimran; Chaim Hershko
Reduced incidence of hyperkalemia and azotemia in patients receiving sulindac compared with indomethacin.
Nephron 1988;48(4):291-5.
1988: Chaim Hershko; D J Weatherall
Iron-chelating therapy.
Critical reviews in clinical laboratory sciences 1988;26(4):303-45.
1986: Chaim Hershko; A Eisenberg; A Avni; E Richter; E Weissenberg
[Lead poisoning in West Bank Arabs caused by contaminated flour].
Harefuah 1986;111(10):339-41.
1986: Chaim Hershko; A G Link; A Pinson; S Grisaru; S Sarel; R W Grady
[Hemochromatosis and iron chelating therapy].
Harefuah 1986;111(10):336-8.
1985: A Eisenberg; A Avni; F Grauer; E Weissenberg; C Acker; M Hamdallah; S Shahin; J Moreb; Chaim Hershko
Identification of community flour mills as the source of lead poisoning in West Bank Arabs.
Archives of internal medicine 1985;145(10):1848-51.
1985: Chaim Hershko; A M Konijn; Gabriela Link; J Moreb; F Grauer; E Weissenberg
Combined use of zinc protoporphyrin (ZPP), mean corpuscular volume and haemoglobin measurements for classifying microcytic RBC disorders in children and young adults.
Clinical and laboratory haematology 1985;7(3):259-69.
1984: Chaim Hershko; A M Konijn; J Moreb; Gabriela Link; F Grauer; E Weissenberg
Iron depletion and blood lead levels in a population with endemic lead poisoning.
Israel journal of medical sciences 1984;20(11):1039-43.
1984: Chaim Hershko; A Abrahamov; J Moreb; M Hersh; R Shiffman; A Shahin; Elihu D Richter; A M Konijn; E Weissenberg; F Graver
Lead poisoning in a West Bank Arab Village.
Archives of internal medicine 1984;144(10):1969-73.
1983: Chaim Hershko; Y Yaffe; Elihu D Richter; A M Konijn; A Abrahamov; M Hersh; J Morreb; E Weissenberg; A Shahin
[Lead poisoning].
Harefuah 1983;105(10):303-6.
1983: S Avramovici-Grisaru; S Sarel; Gabriela Link; Chaim Hershko
Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives.
Journal of medicinal chemistry 1983;26(2):298-302.
1983: J Moreb; M M Popovtzer; Michael M Friedlaender; A M Konijn; Chaim Hershko
Evaluation of iron status in patients on chronic hemodialysis: relative usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume and red cell protoporphyrin.
Nephron 1983;35(3):196-200.
1982: Chaim Hershko; J Moreb; Y Gaziel; A M Konijn; E A Rachmilewitz
Reduced frequency of iron deficiency anaemia in sickle cell trait.
Scandinavian journal of haematology 1982;29(4):304-10.
1981: Chaim Hershko; D Bar-Or; Y Gaziel; E Naparstek; A M Konijn; N Grossowicz; N Kaufman; G Izak
Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations.
The American journal of clinical nutrition 1981;34(8):1600-10.
1981: Chaim Hershko; S Avramovici-Grisaru; Gabriela Link; L Gelfand; S Sarel
Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal.
The Journal of laboratory and clinical medicine 1981;98(1):99-108.
1980: Chaim Hershko; Y Gaziel; D Bar-Or; G Izak; E Naparstek; N Grossowicz; N Kaufman; A M Konijn
Anemia among Druze children in the Golan Heights.
Israel journal of medical sciences 1980;16(5):384-8.