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Paul Hertzog

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Kristie Jenkins; Jing Jing Khoo; Natalie A Borg; Jodee Gould; Paul J Hertzog; Kathryn Hjerrild; Phillip Nagley; Rebecca Piganis; Anthony Sadler; Belinda J Thomas; Die Wang; Ashley Mansell
Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
Samuel C Forster; Jodee A Gould; Alexander M Finkel; Paul J Hertzog
RNA-eXpress annotates novel transcript features in RNA-seq data.
Ka Yee Fung; Caroline E Gargett; Philip M Hansbro; Daniel J Carr; Helen Cumming; Nicole de Weerd; Jay C Horvat; Niamh E Mangan; Jemma R Mayall; Hong P T Nguyen; Belinda Parker; Sarah A Robertson; Laila C Roisman; Jamie Rossjohn; John E Schjenken; Sebastian A Stifter; Paul J Hertzog
Interferon-ε protects the female reproductive tract from viral and bacterial infection.

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All Publications

2013: Kristie Jenkins; Jing Jing Khoo; Natalie A Borg; Jodee Gould; Paul J Hertzog; Kathryn Hjerrild; Phillip Nagley; Rebecca Piganis; Anthony Sadler; Belinda J Thomas; Die Wang; Ashley Mansell
Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
Immunology and cell biology 2013;91(4):321-30.
2013: Samuel C Forster; Jodee A Gould; Alexander M Finkel; Paul J Hertzog
RNA-eXpress annotates novel transcript features in RNA-seq data.
Bioinformatics (Oxford, England) 2013;29(6):810-2.
2013: Ka Yee Fung; Caroline E Gargett; Philip M Hansbro; Daniel J Carr; Helen Cumming; Nicole de Weerd; Jay C Horvat; Niamh E Mangan; Jemma R Mayall; Hong P T Nguyen; Belinda Parker; Sarah A Robertson; Laila C Roisman; Jamie Rossjohn; John E Schjenken; Sebastian A Stifter; Paul J Hertzog
Interferon-ε protects the female reproductive tract from viral and bacterial infection.
Science (New York, N.Y.) 2013;339(6123):1088-92.
2013: Irina Rusinova; Simon Yu; Anitha Kannan; Marion Masse; Ross Chapman; Helen Cumming; Sam Forster; Paul J Hertzog
Interferome v2.0: an updated database of annotated interferon-regulated genes.
Nucleic acids research 2013;41(Database issue):D1040-6.
2012: Paul J Hertzog
Overview. Type I interferons as primers, activators and inhibitors of innate and adaptive immune responses.
Immunology and cell biology 2012;90(5):471-3.
2012: Claire J Greenhill; Paul J Hertzog; Andrew G Jarnicki; Matthias Ernst; Jodee Gould; Ashley Mansell; Brendan J Jenkins
LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.
Immunology and cell biology 2012;90(5):559-63.
2011: Rebecca A R Piganis; Christian W Schindler; Nicole de Weerd; Jodee A Gould; Ashley Mansell; Sandra E Nicholson; Paul J Hertzog
Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2.
The Journal of biological chemistry 2011;286(39):33811-8.
2011: Erika J Lapinskas; Jonathan Cebon; Ian D Davis; Paul J Hertzog; Suzanne Svobodova; Melanie A Pritchard
The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2011;14(4):316-22.
2010: Maria Kaparakis; Lynne Turnbull; Leticia Carneiro; Stephen Firth; Harold A Coleman; Helena C Parkington; Lionel Le Bourhis; Abdulgader Karrar; Jérôme Viala; Johnson Mak; Melanie L Hutton; John K Davies; Peter J Crack; Paul J Hertzog; Dana J Philpott; Stephen E Girardin; Cynthia B Whitchurch; Richard L Ferrero
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells.
Cellular microbiology 2010;12(3):372-85.
2010: Renee L Rogers; Isabelle Van Seuningen; Jodee Gould; Paul J Hertzog; Matthew J Naylor; Melanie A Pritchard
Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.
PloS one 2010;5(10):e13150.
2010: Daniel J Gough; Nicole L Messina; Linda Hii; Jodee A Gould; Kanaga Sabapathy; Ashley P S Robertson; Joseph A Trapani; David E Levy; Paul J Hertzog; chris clarke; Ricky Johnstone
Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
PLoS biology 2010;8(4):e1000361.
2009: Andrew J Fleetwood; Hang Dinh; Andrew D Cook; Paul J Hertzog; John A Hamilton
GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.
Journal of leukocyte biology 2009;86(2):411-21.
2008: Connie H Y Wong; Steven Bozinovski; Paul J Hertzog; Michael J Hickey; Peter J Crack
Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.
Journal of neurochemistry 2008;107(1):241-52.
2007: Susie J Noppert; Katherine A Fitzgerald; Paul J Hertzog
The role of type I interferons in TLR responses.
Immunology and cell biology 2007;85(6):446-57.
2007: Nicole de Weerd; shamith samarajiwa; Paul J Hertzog
Type I interferon receptors: biochemistry and biological functions.
The Journal of biological chemistry 2007;282(28):20053-7.
2007: Debra A O'Leary; Peter G Noakes; Nickolas A Lavidis; Ismail Kola; Paul J Hertzog; Sika Ristevski
Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function.
Molecular and cellular biology 2007;27(9):3470-80.
2007: Nicole Flentjar; Po-Yin Chu; Annie Y-N Ng; Cameron N Johnstone; Joan K Heath; Matthias Ernst; Paul J Hertzog; Melanie A Pritchard
TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.
Gastroenterology 2007;132(4):1410-9.
2007: Trevor J Wilson; Orly Lacham-Kaplan; Jodee Gould; Andrew Holloway; Ivan Bertoncello; Paul J Hertzog; Alan Trounson
Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating.
Molecular reproduction and development 2007;74(4):512-9.
2007: B Verstak; Paul J Hertzog; Ashley Mansell
Toll-like receptor signalling and the clinical benefits that lie within.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007;56(1):1-10.
2006: Peter J Crack; Juliet M Taylor; Ugur Ali; Ashley Mansell; Paul J Hertzog
Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury.
Stroke; a journal of cerebral circulation 2006;37(6):1533-8.
2006: Peter J Crack; K Cimdins; Ugur Ali; Paul J Hertzog; Rocco C Iannello
Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(5):645-57.
2006: Ashley Mansell; Rosealee Smith; Sarah L Doyle; Pearl Gray; Jennifer E Fenner; Peter J Crack; Sandra E Nicholson; Douglas J Hilton; Luke A J O'Neill; Paul J Hertzog
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Nature immunology 2006;7(2):148-55.
2006: Dakang Xu; Trevor J Wilson; Paul J Hertzog
Ultraviolet-induced apoptosis in embryonic stem cells in vitro.
Methods in molecular biology (Clifton, N.J.) 2006;329():327-38.
2006: Jennifer E Fenner; Robyn Starr; Ann L Cornish; Jian-Guo Zhang; Donald Metcalf; Robert D Schreiber; Kathleen Sheehan; Douglas J Hilton; Warren S Alexander; Paul J Hertzog
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
Nature immunology 2006;7(1):33-9.
2005: Judy de Haan; Nada Stefanovic; David J Nikolic-Paterson; Lyndee L Scurr; Kevin D Croft; Trevor A Mori; Paul J Hertzog; Ismail Kola; Robert C Atkins; Gregory H Tesch
Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy.
American journal of physiology. Renal physiology 2005;289(3):F544-51.
2005: Jodie Palmer; Matthias Ernst; Annet Hammacher; Paul J Hertzog
Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo.
The Prostate 2005;62(3):282-9.
2005: Jiong Zhou; Renee Chehab; Josephine Tkalcevic; Matthew J Naylor; Jessica Harris; Trevor J Wilson; Sue Tsao; Irene Tellis; Silva Zavarsek; Dakang Xu; Erika J Lapinskas; Jane E Visvader; Geoffrey J Lindeman; Ross Thomas; Christopher J Ormandy; Paul J Hertzog; Ismail Kola; Melanie A Pritchard
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.
The EMBO journal 2005;24(3):635-44.
2005: Laureane Mittaz; Sharon Ricardo; Gemma Martinez; Ismail Kola; Darren J Kelly; Melissa H Little; Paul J Hertzog; Melanie A Pritchard
Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(2):419-23.
2005: Debra A O'Leary; Daniela Koleski; Ismail Kola; Paul J Hertzog; Sika Ristevski
Identification and expression analysis of alternative transcripts of the mouse GA-binding protein (Gabp) subunits alpha and beta1.
Gene 2005;344():79-92.
2005: Juliet M Taylor; Ugur Ali; Rocco C Iannello; Paul J Hertzog; Peter J Crack
Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death.
Journal of neurochemistry 2005;92(2):283-93.
2004: Debra A O'Leary; Melanie A Pritchard; Dakang Xu; Ismail Kola; Paul J Hertzog; Sika Ristevski
Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS.
Biochimica et biophysica acta 2004;1739(1):81-7.
2004: Erika J Lapinskas; Jodie Palmer; Sharon Ricardo; Paul J Hertzog; Annet Hammacher; Melanie A Pritchard
A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands.
Histochemistry and cell biology 2004;122(6):521-6.
2004: Juliet M Taylor; Peter J Crack; Jodee A Gould; Ugur Ali; Paul J Hertzog; Rocco C Iannello
Akt phosphorylation and NFkappaB activation are counterregulated under conditions of oxidative stress.
Experimental cell research 2004;300(2):463-75.
2004: Jodie Palmer; Paul J Hertzog; Annet Hammacher
Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells.
The international journal of biochemistry & cell biology 2004;36(11):2258-69.
2004: Ashley Mansell; Elizabeth K Brint; Jodee A Gould; Luke A J O'Neill; Paul J Hertzog
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.
The Journal of biological chemistry 2004;279(36):37227-30.
2004: Matthew P Hardy; Catherine M Owczarek; Lars S Jermiin; Mikael Ejdebäck; Paul J Hertzog
Characterization of the type I interferon locus and identification of novel genes.
Genomics 2004;84(2):331-45.
2004: Sika Ristevski; Debra A O'Leary; Anders P Thornell; Michael J Owen; Ismail Kola; Paul J Hertzog
The ETS transcription factor GABPalpha is essential for early embryogenesis.
Molecular and cellular biology 2004;24(13):5844-9.
2004: Laureane Mittaz; D L Russell; T Wilson; Melissa Brasted; J Tkalcevic; Lois salamonsen; Paul J Hertzog; Melanie A Pritchard
Adamts-1 is essential for the development and function of the urogenital system.
Biology of reproduction 2004;70(4):1096-105.
2004: Catherine M Owczarek; KJ Portbury; Matthew P Hardy; Debra A O'Leary; J Kudoh; K Shibuya; N Shimizu; Ismail Kola; Paul J Hertzog
Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.
Gene 2004;324():65-77.
2004: Judy de Haan; Cecile Bladier; Mehrnoush Lotfi-Miri; Juliet Taylor; Paul Hutchinson; Peter J Crack; Paul J Hertzog; Ismail Kola
Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death.
Free radical biology & medicine 2004;36(1):53-64.
2003: Ernst Wolvetang; O M Bradfield; T Hatzistavrou; Peter J Crack; Jorge Busciglio; Ismail Kola; Paul J Hertzog
Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis.
Neurobiology of disease 2003;14(3):349-56.
2003: Paul J Hertzog; Luke A J O'Neill; John A Hamilton
The interferon in TLR signaling: more than just antiviral.
Trends in immunology 2003;24(10):534-9.
2003: E W Wolvetang; O M Bradfield; Martin J Tymms; Silva Zavarsek; T Hatzistavrou; Ismail Kola; Paul J Hertzog
The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome.
Biochimica et biophysica acta 2003;1628(2):105-10.
2003: Naoko Ohtani; Paul Brennan; Stefan Gaubatz; Elaine Sanij; Paul J Hertzog; Ernst Wolvetang; Jacques Ghysdael; Martin Rowe; Eiji Hara
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.
The Journal of cell biology 2003;162(2):173-83.
2003: S Trajanovska; Catherine M Owczarek; P G Stanton; Paul J Hertzog
Generation and characterization of recombinant unmodified and phosphorylatable murine IFN-alpha1 in the methylotropic yeast Pichia pastoris.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(7):351-8.
2003: Elaine Sanij; Bernadette Scott; Trevor Wilson; Dakang Xu; Paul J Hertzog; Ernst Wolvetang
Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein.
Immunology letters 2003;86(1):63-70.
2003: Meredith O'Keeffe; Hubertus Hochrein; David Vremec; Bernadette Scott; Paul J Hertzog; Lilliana Tatarczuch; Ken Shortman
Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors.
Blood 2003;101(4):1453-9.
2003: Matthew P Hardy; Elaine Sanij; Paul J Hertzog; Catherine M Owczarek
Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(2):105-18.
2003: Ernst Wolvetang; Trevor J Wilson; Elaine Sanij; Jorge Busciglio; T Hatzistavrou; A Seth; Paul J Hertzog; Ismail Kola
ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway.
Human molecular genetics 2003;12(3):247-55.
2003: David Chan; Trevor J Wilson; Dakang Xu; H E Cowdery; Elaine Sanij; Paul J Hertzog; Ismail Kola
Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.
British journal of cancer 2003;88(1):137-45.
2003: Judy de Haan; Peter J Crack; Nicole Flentjar; Rocco C Iannello; Paul J Hertzog; Ismail Kola
An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse.
Redox report : communications in free radical research 2003;8(2):69-79.
2003: Peter J Crack; Juliet M Taylor; Judy de Haan; Ismail Kola; Paul J Hertzog; Rocco C Iannello
Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(1):19-22.
2002: Meredith O'Keeffe; Hubertus Hochrein; David Vremec; Irina Caminschi; Joanna L Miller; E Margot Anders; Li Wu; Mireille Lahoud; Sandrine Henri; Bernadette Scott; Paul J Hertzog; Lilliana Tatarczuch; Ken Shortman
Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus.
The Journal of experimental medicine 2002;196(10):1307-19.
2002: Nicole Flentjar; Peter J Crack; Richard Boyd; Mark Malin; Judy de Haan; Paul J Hertzog; Ismail Kola; Rocco C Iannello
Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury.
Experimental neurology 2002;177(1):9-20.
2002: Trevor J Wilson; Helen E Cowdery; Dakang Xu; Ismail Kola; Paul J Hertzog
A human CD2 minigene directs CRE-mediated recombination in T cells in vivo.
Genesis (New York, N.Y. : 2000) 2002;33(4):181-4.
2002: Dakang Xu; Trevor J Wilson; David Chan; Elisabetta De Luca; Jiong Zhou; Paul J Hertzog; Ismail Kola
Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells.
The EMBO journal 2002;21(15):4081-93.
2002: Sika Ristevski; Patrick P L Tam; Paul J Hertzog; Ismail Kola
Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo.
Mechanisms of development 2002;116(1-2):165-8.
2002: Matthew P Hardy; Paul J Hertzog; Catherine M Owczarek
Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression.
The Biochemical journal 2002;365(Pt 2):355-67.
2002: Annie Y-N Ng; Paul Waring; Sika Ristevski; Caroline Wang; Trevor Wilson; Melanie Pritchard; Paul J Hertzog; Ismail Kola
Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium.
Gastroenterology 2002;122(5):1455-66.
2001: Elaine Sanij; T Hatzistavrou; Paul J Hertzog; Ismail Kola; Ernst Wolvetang
Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome.
Biochemical and biophysical research communications 2001;287(4):1003-8.
2001: Peter J Crack; Juliet M Taylor; Nicole Flentjar; Judy de Haan; Paul J Hertzog; Rocco C Iannello; Ismail Kola
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury.
Journal of neurochemistry 2001;78(6):1389-99.
2001: Mireille Lahoud; Sika Ristevski; Deon J Venter; Lars S Jermiin; Ivan Bertoncello; Silva Zavarsek; Suzanne Hasthorpe; J Drago; David M de Kretser; Paul J Hertzog; Ismail Kola
Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.
Genome research 2001;11(8):1327-34.
2001: Sika Ristevski; P P Tam; Ismail Kola; Paul J Hertzog
Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mouse limb development.
Mechanisms of development 2001;104(1-2):139-42.
2001: Hubertus Hochrein; Ken Shortman; David Vremec; B Scott; Paul J Hertzog; Meredith O'Keeffe
Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5448-55.
2001: Matthew P Hardy; Catherine M Owczarek; S Trajanovska; X Liu; Ismail Kola; Paul J Hertzog
The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties.
Blood 2001;97(2):473-82.
2001: A Giudice; Jodee A Gould; K B Freeman; S Rastan; Paul J Hertzog; Ismail Kola; Rocco C Iannello
Identification and characterization of alternatively spliced murine Rgs11 isoforms: genomic structure and gene analysis.
Cytogenetics and cell genetics 2001;94(3-4):216-24.
2001: Catherine M Owczarek; Herbert Treutlein; KJ Portbury; L M Gulluyan; Ismail Kola; Paul J Hertzog
A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1.
Cytogenetics and cell genetics 2001;92(3-4):196-203.
2001: Paul J Hertzog
Isolation of embryonic fibroblasts and their use in the in vitro characterization of gene function.
Methods in molecular biology (Clifton, N.J.) 2001;158():205-15.
2001: Mireille Lahoud; Trevor J Wilson; Paul J Hertzog
Choice of mouse strains for gene targeting.
Methods in molecular biology (Clifton, N.J.) 2001;158():107-19.
2001: Paul J Hertzog; Ismail Kola
Overview. Gene knockouts.
Methods in molecular biology (Clifton, N.J.) 2001;158():1-10.
2000: Catherine M Owczarek; KJ Portbury; Ismail Kola; Paul J Hertzog
Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids.
Cytogenetics and cell genetics 2000;89(3-4):240-1.
1999: Warren S Alexander; Robyn Starr; Jennifer E Fenner; Clare L Scott; Emanuela Handman; Naomi S Sprigg; Jason E Corbin; Ann L Cornish; Rima Darwiche; Catherine M Owczarek; Thomas W H Kay; Nicos A Nicola; Paul J Hertzog; Donald Metcalf; Douglas J Hilton
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Cell 1999;98(5):597-608.
1998: L H McKinlay; Martin J Tymms; RS Thomas; Arun Seth; Suzanne Hasthorpe; Paul J Hertzog; Ismail Kola
The role of Ets-1 in mast cell granulocyte-macrophage colony-stimulating factor expression and activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4098-105.
1998: Judy de Haan; Cecile Bladier; P Griffiths; M Kelner; Ross D O'Shea; Nam Sang Cheung; R T Bronson; M J Silvestro; S Wild; S S Zheng; Philip M Beart; Paul J Hertzog; Ismail Kola
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.
The Journal of biological chemistry 1998;273(35):22528-36.
1997: Catherine M Owczarek; S Y Hwang; K A Holland; L M Gulluyan; M Tavaria; B Weaver; N C Reich; Ismail Kola; Paul J Hertzog
Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2.
The Journal of biological chemistry 1997;272(38):23865-70.
1997: K A Holland; Catherine M Owczarek; S Y Hwang; Martin J Tymms; S N Constantinescu; Lawrence M Pfeffer; Ismail Kola; Paul J Hertzog
A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and Is necessary for transcriptional activation of interferon-regulated genes.
The Journal of biological chemistry 1997;272(34):21045-51.
1997: Ismail Kola; Paul J Hertzog
Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome.
Human molecular genetics 1997;6(10):1713-27.
1996: S Y Hwang; K A Holland; Ismail Kola; Paul J Hertzog
Binding of interferon-alpha and -beta to a component of the human type I interferon receptor expressed in simian cells.
The international journal of biochemistry & cell biology 1996;28(8):911-6.
1996: John A Hamilton; Genevieve A Whitty; I Kola; Paul J Hertzog
Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2553-7.
1995: S Y Hwang; Paul J Hertzog; K A Holland; S H Sumarsono; Martin J Tymms; John A Hamilton; Genevieve A Whitty; I Bertoncello; Ismail Kola
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11284-8.
1995: A H Hart; C M Corrick; Martin J Tymms; Paul J Hertzog; Ismail Kola
Human ERG is a proto-oncogene with mitogenic and transforming activity.
Oncogene 1995;10(7):1423-30.
1995: A L Greenway; Paul J Hertzog; Rodney J Devenish; Anthony Linnane
Constitutive and virus-induced interferon production by peripheral blood leukocytes.
Experimental hematology 1995;23(3):229-35.
1994: A L Greenway; Paul J Hertzog; Rodney J Devenish; F J Dudley; G L McMullen; Anthony Linnane
Immunolocalisation of interferon-alpha in hepatitis C patients and its correlation with response to interferon-alpha therapy.
Journal of hepatology 1994;21(5):842-52.
1994: Paul J Hertzog; S Y Hwang; Ismail Kola
Role of interferons in the regulation of cell proliferation, differentiation, and development.
Molecular reproduction and development 1994;39(2):226-32.
1994: E R Brandt; Rodney J Devenish; Paul J Hertzog; F J Dudley; Anthony Linnane
Detection of interferon-alpha expression by PCR in patients with chronic hepatitis C and hepatitis non-A, non-B.
Journal of gastroenterology and hepatology 1994;9(4):373-80.
1994: S Y Hwang; A L Greenway; G L McMullen; Paul J Hertzog
Detection of cells producing murine interferon-alpha using antipeptide antibodies.
Immunology and cell biology 1994;72(3):234-40.
1994: Paul J Hertzog; S Y Hwang; K A Holland; Martin J Tymms; Rocco C Iannello; Ismail Kola
A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons.
The Journal of biological chemistry 1994;269(19):14088-93.
1994: L Wang; Paul J Hertzog; M Galanis; M L Overall; GJ Waine; Anthony Linnane
Structure-function analysis of human IFN-alpha. Mapping of a conformational epitope by homologue scanning.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):705-15.
1993: E R Brandt; I R Mackay; Paul J Hertzog; B F Cheetham; M Sherritt; Claude C A Bernard
Molecular detection of interferon-alpha expression in multiple sclerosis brain.
Journal of neuroimmunology 1993;44(1):1-5.
1993: A L Greenway; E R Brandt; Paul J Hertzog; Rodney J Devenish; Anthony Linnane
Post-transcriptional regulation of interferon-alpha 4 subtype production by lymphoblastoid cells.
Hematological oncology 1993;11(1):7-21.
1992: T G Johns; I R Mackay; K A Callister; Paul J Hertzog; Rodney J Devenish; Anthony Linnane
Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon beta.
Journal of the National Cancer Institute 1992;84(15):1185-90.
1992: M L Overall; P Chambers; Paul J Hertzog
Different interactions of interferon-alpha subtypes at the surface of epithelial and lymphoid cells.
Journal of interferon research 1992;12(4):281-8.
1992: B E Loveland; T G Johns; I R Mackay; F Vaillant; Z X Wang; Paul J Hertzog
Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays.
Biochemistry international 1992;27(3):501-10.
1992: M L Overall; Paul J Hertzog
Functional analysis of interferon-alpha subtypes using monoclonal antibodies to interferon-alpha 4a--subtype reactivity, neutralisation of biological activities and epitope analysis.
Molecular immunology 1992;29(3):391-9.
1992: A L Greenway; M L Overall; N Sattayasai; Merrill J Rowley; Paul J Hertzog; G L McMullen; B F Cheetham; Sangkot Marzuki
Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines.
Immunology 1992;75(1):182-8.
1991: N Sattayasai; Sangkot Marzuki; G L McMullen; H M Geysen; T J Mason; A R Hibbs; M Overall; Paul J Hertzog; Anthony Linnane
Subtype-specificity of antipeptide antibodies raised against unique sequences of human interferons-alpha.
Molecular immunology 1991;28(9):975-83.
1991: Paul J Hertzog; A Wright; G Harris; Anthony Linnane; I R Mackay
Intermittent interferonemia and interferon responses in multiple sclerosis.
Clinical immunology and immunopathology 1991;58(1):18-32.
1990: Paul J Hertzog; T G Johns; K A Callister; A Dinatale; Anthony Linnane
Comparative antiproliferative and receptor binding activities of interferons alpha and beta on lymphoblastoid and melanoma cells.
Biochemistry international 1990;22(6):1095-102.
1990: T G Johns; J A Kerry; B A Veitch; I R Mackay; P J Tutton; Martin J Tymms; B F Cheetham; Paul J Hertzog; Anthony Linnane
Pharmacokinetics, tissue distribution, and cell localization of [35S]methionine-labeled recombinant human and murine alpha interferons in mice.
Cancer research 1990;50(15):4718-23.
1989: Paul J Hertzog; B F Cheetham; J L Sexton; Anthony Linnane
Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C.
Biochemistry international 1989;19(6):1427-36.
1989: M L Overall; Sangkot Marzuki; Paul J Hertzog
Comparison of different ELISAs for the detection of monoclonal antibodies to human interferon-alpha. Implications for antibody screening.
Journal of immunological methods 1989;119(1):27-33.
1988: Paul J Hertzog; P Emery; B F Cheetham; I R Mackay; Anthony Linnane
Interferons in rheumatoid arthritis: alterations in production and response related to disease activity.
Clinical immunology and immunopathology 1988;48(2):192-201.
1988: M J Jean-François; Paul J Hertzog; Sangkot Marzuki
Isolation and characterisation of monoclonal antibodies against hydrophobic membrane subunit 9 of the yeast mitochondrial H+-ATPase.
Biochimica et biophysica acta 1988;933(1):223-8.
1986: M W Beilharz; I T Nisbet; Martin J Tymms; Paul J Hertzog; Anthony Linnane
Antiviral and antiproliferative activities of interferon-alpha 1: the role of cysteine residues.
Journal of interferon research 1986;6(6):677-85.
1985: I T Nisbet; M W Beilharz; Paul J Hertzog; Martin J Tymms; Anthony Linnane
Single amino acid substitutions at conserved residues of human interferon-alpha can effect antiviral specific activity.
Biochemistry international 1985;11(3):301-9.