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Heiko Herwald

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TOP 3
L I Påhlman; Artur Schmidtchen; G Kasetty; Matthias Mörgelin; A I Olin; Heiko Herwald
Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.
Heiko Herwald
Anti-inflammatory, anti-coagulant, anti-biotic?
Songen Zhang; Heiko Herwald; Bengt Jeppsson; Milladur Rahman; Henrik Thorlacius
Geranylgeranyl transferase regulates streptococcal M1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung.

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All Publications

2013: L I Påhlman; Artur Schmidtchen; G Kasetty; Matthias Mörgelin; A I Olin; Heiko Herwald
Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.
Thrombosis and haemostasis 2013;109(5):930-9.
2013: Heiko Herwald
Anti-inflammatory, anti-coagulant, anti-biotic?
Thrombosis and haemostasis 2013;109(4):582.
2013: Songen Zhang; Heiko Herwald; Bengt Jeppsson; Milladur Rahman; Henrik Thorlacius
Geranylgeranyl transferase regulates streptococcal M1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung.
Shock (Augusta, Ga.) 2013;39(3):293-8.
2013: KM Kaukonen; Lennart Lindbom; Heiko Herwald; Ville Pettila
Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim) - a prospective, placebo-controlled, double-blind study.
BMC infectious diseases 2013;13():51.
2013: Oonagh Shannon; Heiko Herwald; Sonja Oehmcke
Modulation of the coagulation system during severe streptococcal disease.
Current topics in microbiology and immunology 2013;368():189-205.
2013: Heiko Herwald; Arne Egesten
Of DAMPs and macrophages.
Journal of innate immunity 2013;5(1):1.
2012: Songen Zhang; Su Zhang; Heiko Herwald; Bengt Jeppsson; Milladur Rahman; Henrik Thorlacius
Streptococcal m1 protein triggers farnesyltransferase-dependent formation of CXC chemokines in alveolar macrophages and neutrophil infiltration of the lungs.
Infection and immunity 2012;80(11):3952-9.
2012: Michelle S Chew; Anders Ersson; Heiko Herwald; Adam Linder; Stefan Santen; Henrik Thorlacius
Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2012;61(4):375-9.
2012: Songen Zhang; Su Zhang; Heiko Herwald; Bengt Jeppsson; Zhongquan Qi; Milladur Rahman; Henrik Thorlacius
Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling.
Journal of innate immunity 2012;4(4):399-408.
2011: Mercedes Valls Serón; Tom Plug; Philip G de Groot; Heiko Herwald; J Arnoud Marquart; Pauline F Marx; Joost C M Meijers
Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B.
Thrombosis and haemostasis 2011;106(4):609-16.
2011: P Chalupa; Heiko Herwald; Ondrej Beran; N Kaspříková; Margareta Holub
Evaluation of potential biomarkers for the discrimination of bacterial and viral infections.
Infection 2011;39(5):411-7.
2011: Torsten G Loof; Matthias Mörgelin; Anna Norrby-Teglund; Sonja Oehmcke; Anders I Olin; Ulrich Theopold; Gerhard Dickneite; Linda Johansson; Heiko Herwald
Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
Blood 2011;118(9):2589-98.
2011: Cetin Agar; Philip G de Groot; Bas de Laat; Heiko Herwald; Johannes Levels; Stephanie D D C Monk; Matthias Mörgelin; Rolf T Urbanus; Tom van der Poll; Gwendolyn van Os; Joost C M Meijers
β₂-glycoprotein I: a novel component of innate immunity.
Blood 2011;117(25):6939-47.
2011: Songen Zhang; Milladur Rahman; Su Zhang; Zhongquan Qi; Heiko Herwald; Henrik Thorlacius
Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung.
American journal of physiology. Lung cellular and molecular physiology 2011;300(6):L930-9.
2011: Maria Rapala-Kozik; Grazyna Bras; Barbara Chruscicka; Justyna Karkowska-Kuleta; Aneta Sroka; Heiko Herwald; Ky-Anh Nguyen; Sigrun Eick; Jan Potempa; Andrzej Kozik
Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.
Infection and immunity 2011;79(2):797-805.
2011: Heiko Herwald; Arne Egesten
The discovery of pathogen recognition receptors (PRR).
Journal of innate immunity 2011;3(5):435-6.
2011: Heiko Herwald; Ulrich Theopold
Hemostasis in invertebrates and vertebrates: an evolutionary excursion.
Journal of innate immunity 2011;3(1):1-2.
2011: Torsten G Loof; Otto Schmidt; Heiko Herwald; Ulrich Theopold
Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?
Journal of innate immunity 2011;3(1):34-40.
2011: Su Zhang; Songen Zhang; Milladur Rahman; Heiko Herwald; Henrik Thorlacius
Streptococcal M1 protein-induced lung injury is independent of platelets in mice.
Shock (Augusta, Ga.) 2011;35(1):86-91.
2010: Per Akesson; Heiko Herwald; Magnus Rasmussen; Katarina Håkansson; Magnus Abrahamson; Ahmed A K Hasan; Alvin H Schmaier; Werner Müller-Esterl; Lars Björck
Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant.
Microbiology (Reading, England) 2010;156(Pt 12):3660-8.
2010: Sonja Oehmcke; Oonagh Shannon; Matthias Mörgelin; Heiko Herwald
Streptococcal M proteins and their role as virulence determinants.
Clinica chimica acta; international journal of clinical chemistry 2010;411(17-18):1172-80.
2010: Ondrej Beran; Heiko Herwald; Olga Dzupová; Pavel Chalupa; Margareta Holub
Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.
Scandinavian journal of infectious diseases 2010;42(8):634-6.
2010: Thorgerdur Sigurdardottir; Viveka Björck; Heiko Herwald; Matthias Mörgelin; Sigurbjörg Rutardottir; Johan Törnebrant; Mikael Bodelsson
M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activation.
Shock (Augusta, Ga.) 2010;34(1):98-104.
2010: Sonja Oehmcke; Heiko Herwald
Contact system activation in severe infectious diseases.
Journal of molecular medicine (Berlin, Germany) 2010;88(2):121-6.
2010: Zhi Wang; Christine Wilhelmsson; Pavel Hyrsl; Torsten G Loof; Pavel Dobes; Martina Klupp; Olga Loseva; Matthias Mörgelin; Jennifer Iklé; Richard M Cripps; Heiko Herwald; Ulrich Theopold
Pathogen entrapment by transglutaminase--a conserved early innate immune mechanism.
PLoS pathogens 2010;6(2):e1000763.
2010: Torsten G Loof; Oliver Goldmann; André Gessner; Heiko Herwald; Eva Medina
Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.
The American journal of pathology 2010;176(2):754-63.
2010: Ingrid Berkestedt; Heiko Herwald; Lennart Ljunggren; Axel Nelson; Mikael Bodelsson
Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis.
Journal of innate immunity 2010;2(5):478-82.
2009: Erik Malmström; Matthias Mörgelin; Martin Malmsten; Linda Johansson; Anna Norrby-Teglund; Oonagh Shannon; Artur Schmidtchen; Joost C M Meijers; Heiko Herwald
Protein C inhibitor--a novel antimicrobial agent.
PLoS pathogens 2009;5(12):e1000698.
2009: Joakim Johansson; Lennart Lindbom; Heiko Herwald; Folke Sjöberg
Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?
Burns : journal of the International Society for Burn Injuries 2009;35(8):1185-7.
2009: Adam Linder; Bertil Christensson; Heiko Herwald; Lars Björck; Per Akesson
Heparin-binding protein: an early marker of circulatory failure in sepsis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;49(7):1044-50.
2009: Linda Johansson; Anna Linnér; Jonas Sundén-Cullberg; Axana Haggar; Heiko Herwald; Karin Loré; Carl Johan Treutiger; Anna Norrby-Teglund
Neutrophil-derived hyperresistinemia in severe acute streptococcal infections.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):4047-54.
2009: Sonja Oehmcke; Oonagh Shannon; Maren von Köckritz-Blickwede; Matthias Mörgelin; Adam Linder; Anders I Olin; Lars Björck; Heiko Herwald
Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen.
Blood 2009;114(2):444-51.
2009: Sonja Oehmcke; Matthias Mörgelin; Heiko Herwald
Activation of the human contact system on neutrophil extracellular traps.
Journal of innate immunity 2009;1(3):225-30.
2009: Heiko Herwald; Arne Egesten
Bacterial proteases disarming host defense.
Journal of innate immunity 2009;1(2):69.
2009: Sara H Bengtson; Caroline Sandén; Matthias Mörgelin; Pauline F Marx; Anders I Olin; L M Fredrik Leeb-Lundberg; Joost C M Meijers; Heiko Herwald
Activation of TAFI on the surface of Streptococcus pyogenes evokes inflammatory reactions by modulating the kallikrein/kinin system.
Journal of innate immunity 2009;1(1):18-28.
2008: Maren von Köckritz-Blickwede; Manfred Rohde; Sonja Oehmcke; Lloyd S Miller; Ambrose L Cheung; Heiko Herwald; Simon Foster; Eva Medina
Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model.
The American journal of pathology 2008;173(6):1657-68.
2008: Sara H Bengtson; Jane Eddleston; Matthias Mörgelin; Bruce L Zuraw; Heiko Herwald
Regulation of kinin B(2) receptors by bradykinin in human lung cells.
Biological chemistry 2008;389(11):1435-40.
2008: Oliver Soehnlein; Ylva Kai-Larsen; Robert Frithiof; Ole E Sorensen; Ellinor Kenne; Karin Scharffetter-Kochanek; Einar E Eriksson; Heiko Herwald; Birgitta Agerberth; Lennart Lindbom
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.
The Journal of clinical investigation 2008;118(10):3491-502.
2008: Oliver Soehnlein; Alma Zernecke; Einar E Eriksson; Antonio Gigliotti Rothfuchs; Christine T Pham; Heiko Herwald; Kiril Bidzhekov; Martin Rottenberg; Christian Weber; Lennart Lindbom
Neutrophil secretion products pave the way for inflammatory monocytes.
Blood 2008;112(4):1461-71.
2008: Oliver Soehnlein; S Oehmcke; X Ma; Antonio Gigliotti Rothfuchs; Robert Frithiof; Nico van Rooijen; M Mörgelin; Heiko Herwald; Lennart Lindbom
Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(2):405-12.
2008: Caroline Sandén; Johan Enquist; Sara H Bengtson; Heiko Herwald; L M Fredrik Leeb-Lundberg
Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation.
The Journal of pharmacology and experimental therapeutics 2008;326(1):24-32.
2008: Maria Nilsson; Sylwia Wasylik; Matthias Mörgelin; Anders I Olin; Joost C M Meijers; R H W M Derksen; Philip G de Groot; Heiko Herwald
The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes.
Molecular microbiology 2008;67(3):482-92.
2008: Lisa I Påhlman; Anders I Olin; Jessica Darenberg; Matthias Mörgelin; Malak Kotb; Heiko Herwald; Anna Norrby-Teglund
Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation.
Cellular microbiology 2008;10(2):404-14.
2008: Fredrik Kahn; Matthias Mörgelin; Oonagh Shannon; Anna Norrby-Teglund; Heiko Herwald; Anders I Olin; Lars Björck
Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.
PLoS pathogens 2008;4(9):e1000149.
2007: Inga-Maria Frick; Lars Björck; Heiko Herwald
The dual role of the contact system in bacterial infectious disease.
Thrombosis and haemostasis 2007;98(3):497-502.
2007: Lisa I Påhlman; Pauline F Marx; Matthias Mörgelin; Slawomir Lukomski; Joost C M Meijers; Heiko Herwald
Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B.
The Journal of biological chemistry 2007;282(34):24873-81.
2007: Lisa I Påhlman; Erik Malmström; Matthias Mörgelin; Heiko Herwald
M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes.
Microbiology (Reading, England) 2007;153(Pt 8):2458-64.
2006: Inga-Maria Frick; Per Akesson; Heiko Herwald; Matthias Mörgelin; Martin Malmsten; Dorit Nägler; Lars Björck
The contact system--a novel branch of innate immunity generating antibacterial peptides.
The EMBO journal 2006;25(23):5569-78.
2006: Sara H Bengtson; Stephen B Phagoo; Anna Norrby-Teglund; Lisa Påhlman; Matthias Mörgelin; Bruce L Zuraw; L M Fredrik Leeb-Lundberg; Heiko Herwald
Kinin receptor expression during Staphylococcus aureus infection.
Blood 2006;108(6):2055-63.
2006: Lisa I Påhlman; Matthias Mörgelin; Jana Eckert; Linda Johansson; Wayne Russell; Kristian Riesbeck; Oliver Soehnlein; Lennart Lindbom; Anna Norrby-Teglund; Ralf R Schumann; Lars Björck; Heiko Herwald
Streptococcal M protein: a multipotent and powerful inducer of inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1221-8.
2006: Maria Nilsson; Ole E Sørensen; Matthias Mörgelin; Maria Weineisen; Ulf Sjöbring; Heiko Herwald
Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators.
Thrombosis and haemostasis 2006;95(6):982-90.
2004: Katarina Lundqvist; Heiko Herwald; Andreas Sonesson; Artur Schmidtchen
Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa.
Thrombosis and haemostasis 2004;92(2):281-7.
2004: Heiko Herwald; Henning Cramer; Matthias Mörgelin; Wayne Russell; Ulla Sollenberg; Anna Norrby-Teglund; Hans Flodgaard; Lennart Lindbom; Lars Björck
M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.
Cell 2004;116(3):367-79.
2003: Eva Mattsson; Heiko Herwald; Arne Egesten
Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 beta.
Journal of thrombosis and haemostasis : JTH 2003;1(12):2569-76.
2003: Kristin Persson; Wayne Russell; Matthias Mörgelin; Heiko Herwald
The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptides.
The Journal of biological chemistry 2003;278(34):31884-90.
2003: Heiko Herwald; Matthias Mörgelin; B Dahlbäck; Lars Björck
Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma.
Journal of thrombosis and haemostasis : JTH 2003;1(2):284-91.
2003: Heiko Herwald; Matthias Mörgelin; Lars Björck
Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis.
Scandinavian journal of infectious diseases 2003;35(9):604-7.
2003: Hans Tapper; Heiko Herwald
Modulation of membrane traffic by microorganisms.
Contributions to microbiology 2003;10():58-74.
2002: Arne Olsén; Heiko Herwald; Mats Wikström; Kristin Persson; Eva Mattsson; Lars Björck
Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coli.
The Journal of biological chemistry 2002;277(37):34568-72.
2002: Robin Kahn; Heiko Herwald; Werner Müller-Esterl; Roland Schmitt; Ann-Christine Sjögren; Lennart Truedsson; Diana Karpman
Contact-system activation in children with vasculitis.
Lancet 2002;360(9332):535-41.
2002: Eva Mattsson; Heiko Herwald; Lars Björck; Arne Egesten
Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes.
Infection and immunity 2002;70(6):3033-9.
2002: Hans Tapper; Anna Karlsson; Matthias Mörgelin; Hans Flodgaard; Heiko Herwald
Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles.
Blood 2002;99(5):1785-93.
2001: N Gautam; A M Olofsson; Heiko Herwald; L F Iversen; Evy Lundgren-Akerlund; P Hedqvist; K E Arfors; Hans Flodgaard; Lennart Lindbom
Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability.
Nature medicine 2001;7(10):1123-7.
2001: Eva Mattsson; Heiko Herwald; H Cramer; K Persson; Ulf Sjöbring; Lars Björck
Staphylococcus aureus induces release of bradykinin in human plasma.
Infection and immunity 2001;69(6):3877-82.
2001: Heiko Herwald; Matthias Mörgelin; H G Svensson; Ulf Sjöbring
Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation.
European journal of biochemistry / FEBS 2001;268(2):396-404.
2000: K Persson; Matthias Mörgelin; Lennart Lindbom; P Alm; Lars Björck; Heiko Herwald
Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system.
The Journal of experimental medicine 2000;192(10):1415-24.
2000: Hans Tapper; Heiko Herwald
Modulation of hemostatic mechanisms in bacterial infectious diseases.
Blood 2000;96(7):2329-37.
2000: N Gautam; Heiko Herwald; P Hedqvist; Lennart Lindbom
Signaling via beta(2) integrins triggers neutrophil-dependent alteration in endothelial barrier function.
The Journal of experimental medicine 2000;191(11):1829-39.
1999: A M Olofsson; Mikael Vestberg; Heiko Herwald; J Rygaard; G David; K E Arfors; Viggo Linde; Hans Flodgaard; Jürgen Dedio; Werner Müller-Esterl; Evy Lundgren-Akerlund
Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis.
The Journal of clinical investigation 1999;104(7):885-94.
1998: Heiko Herwald; Matthias Mörgelin; Arne Olsén; M Rhen; B Dahlbäck; W Müller-Esterl; Lars Björck
Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases.
Nature medicine 1998;4(3):298-302.
1997: A Ben Nasr; Heiko Herwald; Ulf Sjöbring; T Renné; W Müller-Esterl; Lars Björck
Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin.
The Biochemical journal 1997;326 ( Pt 3)():657-60.
1996: Heiko Herwald; Mattias Collin; Werner Müller-Esterl; Lars Björck
Streptococcal cysteine proteinase releases kinins: a virulence mechanism.
The Journal of experimental medicine 1996;184(2):665-73.
1996: Heiko Herwald; Thomas Renné; J C Meijers; Dominic W Chung; J D Page; R W Colman; Werner Müller-Esterl
Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4.
The Journal of biological chemistry 1996;271(22):13061-7.
1996: Heiko Herwald; Jürgen Dedio; R Kellner; Michael Loos; Werner Müller-Esterl
Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor.
The Journal of biological chemistry 1996;271(22):13040-7.
1995: Ahmed Hasan; Douglas B Cines; Heiko Herwald; Alvin H Schmaier; Werner Müller-Esterl
Mapping the cell binding site on high molecular weight kininogen domain 5.
The Journal of biological chemistry 1995;270(33):19256-61.
1995: Heiko Herwald; Ahmed Hasan; Jasminka Godovac-Zimmermann; Alvin H Schmaier; Werner Müller-Esterl
Identification of an endothelial cell binding site on kininogen domain D3.
The Journal of biological chemistry 1995;270(24):14634-42.
1993: Heiko Herwald; Willi Jahnen-Dechent; S A Alla; J Hock; B N Bouma; Werner Müller-Esterl
Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain.
The Journal of biological chemistry 1993;268(19):14527-35.
1992: Heiko Herwald; H Hock; Willi Jahnen-Dechent; Werner Müller-Esterl
Mapping of the H-kininogen binding site exposed by the prekallikrein heavy chain.
Agents and actions. Supplements 1992;38 ( Pt 1)():225-32.