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Stefan Herzig

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Wanchana Jangsangthong; Elza Kuzmenkina; Ann Kristin Böhnke; Stefan Herzig
Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.
Sara Dizayee; Peter Hein; Sonja Kaestner; Christoph Klein; Fabian Kuck; Jan Matthes; Janos Meszaros; Bernd Nürnberg; Roland P Piekorz; Stefan Herzig
Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.
Wanchana Jangsangthong; Elza Kuzmenkina; Ismail F Y Khan; Jan Matthes; Roger Hullin; Stefan Herzig
Inactivation of L-type calcium channels is determined by the length of the N terminus of mutant beta(1) subunits.

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2011: Wanchana Jangsangthong; Elza Kuzmenkina; Ann Kristin Böhnke; Stefan Herzig
Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.
Biophysical journal 2011;101(11):2661-70.
2011: Sara Dizayee; Peter Hein; Sonja Kaestner; Christoph Klein; Fabian Kuck; Jan Matthes; Janos Meszaros; Bernd Nürnberg; Roland P Piekorz; Stefan Herzig
Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.
PloS one 2011;6(9):e24979.
2010: Wanchana Jangsangthong; Elza Kuzmenkina; Ismail F Y Khan; Jan Matthes; Roger Hullin; Stefan Herzig
Inactivation of L-type calcium channels is determined by the length of the N terminus of mutant beta(1) subunits.
Pflügers Archiv : European journal of physiology 2010;459(3):399-411.
2010: Jan Matthes; Stefan Herzig
Less is more, or enough is enough? Ca(2+)-dependent inactivation revisited.
The Journal of physiology 2010;588(Pt 1):15-6.
2009: Nadine Beetz; Lutz Hein; Janos Meszaros; Ralf Gilsbach; Frederico Barreto; Marcel Meissner; Uta C Hoppe; Arnold Schwartz; Stefan Herzig; Jan Matthes
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.
Cardiovascular research 2009;84(3):396-406.
2009: Peter Bartels; Kerstin Behnke; Guido Michels; Ferdi Groner; Toni Schneider; Margit Henry; Paula Q Barrett; Ho-Won Kang; Jung-Ha Lee; Martin H J Wiesen; Jan Matthes; Stefan Herzig
Structural and biophysical determinants of single Ca(V)3.1 and Ca(V)3.2 T-type calcium channel inhibition by N(2)O.
Cell calcium 2009;46(4):293-302.
2009: Jasmin Herz; Julian Pardo; Hamid Kashkar; Michael Schramm; Elza Kuzmenkina; Erik Bos; Katja Wiegmann; Reinhard Wallich; Peter J Peters; Stefan Herzig; Elmon Schmelzer; Martin Krönke; Markus M Simon; Olaf Utermöhlen
Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.
Nature immunology 2009;10(7):761-8.
2009: Mathias C Brandt; Jeannette Endres-Becker; Naufal Zagidullin; Lukas J Motloch; Fikret Er; Dennis Rottlaender; Guido Michels; Stefan Herzig; Uta C Hoppe
Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H355-63.
2009: Guido Michels; Ismail F Khan; Jeannette Endres-Becker; Dennis Rottlaender; Stefan Herzig; Arjang Ruhparwar; Thorsten Wahlers; Uta C Hoppe
Regulation of the human cardiac mitochondrial Ca2+ uptake by 2 different voltage-gated Ca2+ channels.
Circulation 2009;119(18):2435-43.
2008: Jan Matthes; Alexander Look; Amina K Hahne; Ara Tekian; Stefan Herzig
The semi-structured triple jump--a new assessment tool reflects qualifications of tutors in a PBL course on basic pharmacology.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(1):55-63.
2007: Stefan Herzig; Ismail F Y Khan; Dirk Gründemann; Jan Matthes; Andreas Ludwig; Guido Michels; Uta C Hoppe; Dipayan Chaudhuri; Arnold Schwartz; David T Yue; Roger Hullin
Mechanism of Ca(v)1.2 channel modulation by the amino terminus of cardiac beta2-subunits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1527-38.
2007: Dennis Rottlaender; Jan Matthes; Stephen F Vatner; Roland Seifert; Stefan Herzig
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate.
The Journal of pharmacology and experimental therapeutics 2007;321(2):608-15.
2007: Roger Hullin; Jan Matthes; Sibylle von Vietinghoff; Ilona Bodi; Marta Rubio; Karen D'Souza; Ismail Friedrich Khan; Dennis Rottländer; Uta C Hoppe; Paul Mohacsi; Eva Schmitteckert; Ralf Gilsbach; Moritz Bünemann; Lutz Hein; Arnold Schwartz; Stefan Herzig
Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.
PloS one 2007;2(3):e292.
2006: Stefan Herzig; L Biehl; H Stelberg; Christian Hick; Norbert Schmeisser; Armin Koerfer
[When is a doctor a good doctor? An analysis of the contents of statements by representatives of the medical profession ].
Deutsche medizinische Wochenschrift (1946) 2006;131(51-52):2883-8.
2006: Guido Michels; Fikret Er; Michael Eicks; Stefan Herzig; Uta C Hoppe
Long-term and immediate effect of testosterone on single T-type calcium channel in neonatal rat cardiomyocytes.
Endocrinology 2006;147(11):5160-9.
2006: Laetitia Pereira; Jan Matthes; Iris Schuster; Héctor H Valdivia; Stefan Herzig; Sylvain Richard; Ana Gomez
Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice.
Diabetes 2006;55(3):608-15.
2005: Guido Michels; Stefan Herzig; Uta C Hoppe
[Levosimendan].
Deutsche medizinische Wochenschrift (1946) 2005;130(43):2444-6.
2005: Amina Katharina Hahne; Ralf Benndorf; Peter Frey; Stefan Herzig
Attitude towards computer-based learning: determinants as revealed by a controlled interventional study.
Medical education 2005;39(9):935-43.
2005: Guido Michels; Fikret Er; Ismail Khan; Michael Südkamp; Stefan Herzig; Uta C Hoppe
Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.
Circulation 2005;111(4):399-404.
2004: Torsten Christ; Melinda Wüst; Jan Matthes; Michael Jänchen; Susanne Jürgens; Stefan Herzig; Erich Wettwer; Dobromir Dobrev; Klaus Matschke; Dietrich Mebs; Ursula Ravens
An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(6):474-83.
2004: Jan Matthes; Leyla Yildirim; Georg Wietzorrek; Daniel Reimer; Jörg Striessnig; Stefan Herzig
Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(6):554-62.
2004: Susanne Wirtz; Stefan Herzig
Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine.
British journal of pharmacology 2004;142(2):275-84.
2004: Katharina Foerster; Tomas Kaeferstein; Ferdi Groner; Stefan Engelhardt; Jan Matthes; Walter J Koch; Martin J Lohse; Stefan Herzig
Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(5):490-5.
2004: Ferdi Groner; Marta Rubio; Patrick Schulte-Euler; Jan Matthes; Ismail F Y Khan; Ilona Bodi; Sheryl E Koch; Arnold Schwartz; Stefan Herzig
Single-channel gating and regulation of human L-type calcium channels in cardiomyocytes of transgenic mice.
Biochemical and biophysical research communications 2004;314(3):878-84.
2004: Jan Matthes; Andreas Jäger; Renate Handrock; Ferdi Groner; Uwe Mehlhorn; Robert H G Schwinger; Gyula Varadi; Arnold Schwartz; Stefan Herzig
Ca2+-dependent modulation of single human cardiac L-type calcium channels by the calcineurin inhibitor cyclosporine.
Journal of molecular and cellular cardiology 2004;36(2):241-55.
2003: Katharina Foerster; Ferdi Groner; Jan Matthes; Walter J Koch; Lutz Birnbaumer; Stefan Herzig
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14475-80.
2003: Roger Hullin; Ismail Friedrich Yunus Khan; Susanne Wirtz; Paul Mohacsi; Gyula Varadi; Arnold Schwartz; Stefan Herzig
Cardiac L-type calcium channel beta-subunits expressed in human heart have differential effects on single channel characteristics.
The Journal of biological chemistry 2003;278(24):21623-30.
2003: Stefan Herzig; Ralph-Mario Linke; Bent Marxen; Ulf Börner; Wolfram Antepohl
Long-term follow up of factual knowledge after a single, randomised problem-based learning course.
BMC medical education 2003;3():3.
2002: Jan Matthes; Bent Marxen; Ralph-Mario Linke; Wolfram Antepohl; Silke Coburger; Hildegard Christ; Walter Lehmacher; Stefan Herzig
The influence of tutor qualification on the process and outcome of learning in a problem-based course of basic medical pharmacology.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(1):58-63.
2002: Guido Michels; Jan Matthes; Renate Handrock; Ute Kuchinke; Ferdi Groner; Leanne L Cribbs; Alexey Pereverzev; Toni Schneider; Edward Perez-Reyes; Stefan Herzig
Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels.
Molecular pharmacology 2002;61(3):682-94.
2001: Jan Matthes; F Mathen; Stefan Herzig; Klaus Wassermann
[Therapy of severe pulmonary hypertension with prostacyclin and iloprost].
Deutsche medizinische Wochenschrift (1946) 2001;126(21):631-7.
2001: Jürgen F Heubach; Eva M Graf; P Molenaar; A Jäger; F Schröder; Stefan Herzig; Sian E Harding; Ursula Ravens
Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor.
British journal of pharmacology 2001;133(1):73-82.
2000: Hartmut Lüss; O Klein-Wiele; Peter Bokník; Stefan Herzig; Jörg Knapp; Bettina Linck; Frank U Müller; Hans H Scheld; C Schmid; Wilhelm Schmitz; Joachim Neumann
Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.
Journal of molecular and cellular cardiology 2000;32(12):2349-59.
2000: Peter Bokník; M Fockenbrock; Stefan Herzig; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; T Müller; Wilhelm Schmitz; F Schröder; Joachim Neumann
Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(3):222-31.
2000: Jan Matthes; Irene G Huber; O Haaf; Wolfram Antepohl; Jörg Striessnig; Stefan Herzig
Pharmacodynamic interaction between mibefradil and other calcium channel blockers.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(6):578-83.
2000: U Kreuzberg; Peter Theissen; Harald Schicha; F Schröder; Uwe Mehlhorn; Ernst-Rainer de Vivie; Peter Bokník; J Neumann; C Grohé; Stefan Herzig
Single-channel activity and expression of atrial L-type Ca(2+) channels in patients with latent hyperthyroidism.
American journal of physiology. Heart and circulatory physiology 2000;278(3):H723-30.
1999: Lev M Yagupolskii; Wolfram Antepohl; Ferruh Artunc; Renate Handrock; B M Klebanov; I I Maletina; Bent Marxen; K I Petko; Ulrich Quast; A Vogt; C Weiss; J Zibold; Stefan Herzig
Vasorelaxation by new hybrid compounds containing dihydropyridine and pinacidil-like moieties.
Journal of medicinal chemistry 1999;42(25):5266-71.
1999: Renate Handrock; RA Rao-Schymanski; N Klugbauer; F Hofmann; Stefan Herzig
Dihydropyridine enantiomers block recombinant L-type Ca2+ channels by two different mechanisms.
The Journal of physiology 1999;521 Pt 1():31-42.
1999: Melani Lauven; Renate Handrock; A Müller; F Hofmann; Stefan Herzig
Interaction of three structurally distinct Ca2+ channel activators with single L-type Ca2+ channels.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(2):122-8.
1999: F Schröder; Stefan Herzig
Effects of beta2-adrenergic stimulation on single-channel gating of rat cardiac L-type Ca2+ channels.
The American journal of physiology 1999;276(3 Pt 2):H834-43.
1999: Wolfram Antepohl; Stefan Herzig
Problem-based learning versus lecture-based learning in a course of basic pharmacology: a controlled, randomized study.
Medical education 1999;33(2):106-13.
1998: F Schröder; Renate Handrock; Dirk J Beuckelmann; Stephan Hirt; Roger Hullin; L Priebe; Robert H G Schwinger; J Weil; Stefan Herzig
Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle.
Circulation 1998;98(10):969-76.
1998: Renate Handrock; F Schröder; Stephan Hirt; A Haverich; Clemens Mittmann; Stefan Herzig
Single-channel properties of L-type calcium channels from failing human ventricle.
Cardiovascular research 1998;37(2):445-55.
1998: F Schröder; Stefan Herzig
[Cyclosporine].
Deutsche medizinische Wochenschrift (1946) 1998;123(5):121-2.
1998: Renate Handrock; Stefan Herzig
[Amlodipine].
Deutsche medizinische Wochenschrift (1946) 1998;123(1-2):19-20.
1997: Wolfram Antepohl; Stefan Herzig; M Böhm
[Carvedilol].
Deutsche medizinische Wochenschrift (1946) 1997;122(25-26):833-4.
1996: U Vahlensieck; Peter Bokník; Jörg Knapp; Bettina Linck; Frank U Müller; J Neumann; Stefan Herzig; Hartmut Schlüter; Walter Zidek; M C Deng; Hans H Scheld; W Schmitz
Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors.
British journal of pharmacology 1996;119(5):835-44.
1996: Jörg Seebeck; Wolfgang E Schmidt; H Kilbinger; J Neumann; N Zimmermann; Stefan Herzig
PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(4):424-30.
1996: Renate Handrock; Stefan Herzig
Stereoselectivity of Ca2+ channel block by dihydropyridines: no modulation by the voltage protocol.
European journal of pharmacology 1996;309(3):317-21.
1996: Stefan Herzig
Ca2+ channel activation by CGP 48506, a new positive inotropic benzodiazocine derivative.
European journal of pharmacology 1996;295(1):113-7.
1995: D Heber; Stefan Herzig; Frank Moosig; H Neujahr
Derivatives of 3-digitoxigenone amidinohydrazone: synthesis and effect on the digitalis receptor of several species. Part 7: Compounds with positive inotropic activity.
Die Pharmazie 1995;50(10):663-7.
1995: Stefan Herzig; H Mönig
[Octreotide].
Deutsche medizinische Wochenschrift (1946) 1995;120(30):1051-2.
1995: J Neumann; Stefan Herzig; Peter Boknik; M Apel; G Kaspareit; W Schmitz; H Scholz; M Tepel; N Zimmermann
On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor.
The Journal of pharmacology and experimental therapeutics 1995;274(1):530-9.
1995: Stefan Herzig; J Jischa; A Beinhauer; B Geirhos; K Tacke; Ralf G Hempelmann
Quinidine-induced potentiation of cardiovascular effects of nitrendipine: functional aspects and possible molecular mechanisms.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(6):636-43.
1995: K Wiechen; David T Yue; Stefan Herzig
Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca2+ channels.
The Journal of physiology 1995;484 ( Pt 3)():583-92.
1995: Ralf G Hempelmann; I Papadopoulos; Stefan Herzig
Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum.
European journal of pharmacology 1995;276(3):277-80.
1994: J Neumann; Peter Bokník; Stefan Herzig; W Schmitz; H Scholz; K Wiechen; N Zimmermann
Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor.
The Journal of pharmacology and experimental therapeutics 1994;271(1):535-41.
1994: Hinnerk Wulf; J Gödicke; Stefan Herzig
Functional interaction between local anaesthetics and calcium antagonists in guineapig myocardium: 2. Electrophysiological studies with bupivacaine and nifedipine.
British journal of anaesthesia 1994;73(3):364-70.
1994: Stefan Herzig; L Ruhnke; Hinnerk Wulf
Functional interaction between local anaesthetics and calcium antagonists in guineapig myocardium: 1. Cardiodepressant effects in isolated organs.
British journal of anaesthesia 1994;73(3):357-63.
1994: Stefan Herzig; D Heber; A Mescheder; U Reifenstein-Herzig; T Thormann; M Verborg; K Mohr
Pharmacological characterization of positive inotropic derivatives of 4-amino-7-methyl-1,8-naphthyridine-3-carboxylic acid.
Arzneimittel-Forschung 1994;44(8):937-42.
1993: F Schröder; Stefan Herzig
Pattern of interaction between dihydropyridine calcium antagonists and cationic amphiphilic drugs in isolated guinea-pig left atria.
Arzneimittel-Forschung 1993;43(11):1148-51.
1993: Stefan Herzig; Parag G Patil; J Neumann; C M Staschen; David T Yue
Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gating.
Biophysical journal 1993;65(4):1599-612.
1993: J Neumann; Peter Boknik; Stefan Herzig; W Schmitz; H Scholz; Ramesh Gupta; A M Watanabe
Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid.
The American journal of physiology 1993;265(1 Pt 2):H257-66.
1992: Stefan Herzig; H Lüllmann; H Sieg
Frequency- and potential-dependency of the negative inotropic action of various dihydropyridine and non-dihydropyridine calcium antagonists.
Pharmacology & toxicology 1992;71(3 Pt 1):229-35.
1992: J Gödicke; Stefan Herzig; A Mescheder; K Mohr; F Steinke
Enantioselectivity of asocainol studied at different conditions: a novel approach to check the feasibility of molecular models of antiarrhythmic drug action.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(3):345-51.
1992: S Braun; N Frey; Stefan Herzig; C Hilbert
Potentiation of cardiodepressive action among calcium antagonists from different classes: evidence for a mechanism at the single calcium channel level.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(5):586-93.
1992: Stefan Herzig
Marked dependence of the cardiac effects of gallopamil on the extracellular K(+)-concentration.
General pharmacology 1992;23(3):403-8.
1991: Stefan Herzig; E Lilienthal; K Mohr
The positive inotropic drugs DPI 201-106, BDF 9148, and veratridine increase ouabain toxicity and [3H]ouabain binding in guinea pig heart.
Journal of cardiovascular pharmacology 1991;18(2):182-9.
1991: C Borst; Ralf G Hempelmann; Stefan Herzig; K Mohr
Modulation of ouabain binding in beating ventricular myocardium from guinea-pigs: effects of lidocaine and monensin.
Pharmacology & toxicology 1991;68(4):243-8.
1991: Stefan Herzig; K Mohr; S Schmidt; J Splieth
Diastolic tension and contraction amplitude in calcium-loaded rat ventricular myocardium are differently affected by drugs.
General pharmacology 1991;22(5):793-6.
1990: Stefan Herzig; A Koch; M Pfaffendorf
Differentiation between negative inotropic drugs by means of potentiated post-rest contractions in guinea-pig heart.
General pharmacology 1990;21(6):881-6.
1990: David T Yue; Stefan Herzig; Eduardo Marban
Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):753-7.
1989: Stefan Herzig; H Lüllmann
The binding of (+)-isradipine by guinea-pig intact atria.
British journal of pharmacology 1989;97(4):1246-50.
1988: Stefan Herzig; H Lüllmann; K Mohr; R Schmitz
Interpretation of [3H]ouabain binding in guinea-pig ventricular myocardium in relation to sodium pump activity.
The Journal of physiology 1988;396():105-20.
1987: Stefan Herzig; H Lüllmann; K Mohr; B Seemann
Acrihellin, a cardioactive steroid escaping from the organ-bath.
Naunyn-Schmiedeberg's archives of pharmacology 1987;335(3):326-30.
1985: Stefan Herzig; H Lüllmann; K Mohr
On the cooperativity of ouabain-binding to intact myocardium.
Journal of molecular and cellular cardiology 1985;17(11):1095-104.