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Robert Aslanian

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Dong Xiao; Wei Zhou; Robert Aslanian; Xiao Chen; James Fossetta; Zhuyan Guo; Xianhai Huang; Anandan Palani; Michael Sofolarides; Peter Spacciapoli; Fang Tian; Prashant Trivedi; Charles E Whitehurst; Daniel Lundell
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Hongmei Li; Anandan Palani; Dmitri A Pissarnitski; Jun Qin; Lixin Song; Monica Vicarel; Lili Zhang; Wei Zhou; Zhaoning Zhu; Robert Aslanian; Thomas A Bara; Inhou Chu; John W Clader; Mary E Cohen-Williams; David Cole; Michael Czarniecki; Pawan Dhondi; William Greenlee; Lynn Hyde; Hubert Josien; Xianhai Huang
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Purakkattle Biju; Rema Bitar; Richard Chapman; Stephen Eckel; Xiomara Fernandez; Aileen House; Yanlin Jia; Johanna Jimenez; Yoon Joo Lee; Gissela Lieber; Yeon-Hee Lim; Kevin McCormick; Robbie Mcleod; John C Anthes; Robert Aslanian; Michael Berlin; Daniel Prelusky; Hongwu Wang; Jonathan Phillips
Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).

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All Publications

2013: Dong Xiao; Wei Zhou; Robert Aslanian; Xiao Chen; James Fossetta; Zhuyan Guo; Xianhai Huang; Anandan Palani; Michael Sofolarides; Peter Spacciapoli; Fang Tian; Prashant Trivedi; Charles E Whitehurst; Daniel Lundell
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(11):3262-6.
2013: Hongmei Li; Anandan Palani; Dmitri A Pissarnitski; Jun Qin; Lixin Song; Monica Vicarel; Lili Zhang; Wei Zhou; Zhaoning Zhu; Robert Aslanian; Thomas A Bara; Inhou Chu; John W Clader; Mary E Cohen-Williams; David Cole; Michael Czarniecki; Pawan Dhondi; William Greenlee; Lynn Hyde; Hubert Josien; Xianhai Huang
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters 2013;23(2):466-71.
2012: Purakkattle Biju; Rema Bitar; Richard Chapman; Stephen Eckel; Xiomara Fernandez; Aileen House; Yanlin Jia; Johanna Jimenez; Yoon Joo Lee; Gissela Lieber; Yeon-Hee Lim; Kevin McCormick; Robbie Mcleod; John C Anthes; Robert Aslanian; Michael Berlin; Daniel Prelusky; Hongwu Wang; Jonathan Phillips
Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).
Bioorganic & medicinal chemistry letters 2012;22(9):3291-5.
2012: Dong Xiao; Robert Aslanian; Joyce J Hwa; Jean E Lachowicz; Anandan Palani; Michael Sofolarides; Christopher Sondey; Robert E West; Shirley M Williams; Ren-Long Wu; Walter A Korfmacher
Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists.
Bioorganic & medicinal chemistry letters 2012;22(9):3354-7.
2012: Rongze Kuang; Ling Lin; John J Piwinski; Daniel Prelusky; John Schwerdt; Neng-Yang Shih; Ho-Jane Shue; Pauline C Ting; Robert Aslanian; Motasim Billah; David J Blythin; Jianhua Cao; Chander S Celly; Xiao Chen; Danlin Gu; Ping Wu; Li Xiao; Ji Zhang; Xiang Zhang; Peng Wang
Discovery of oxazole-based PDE4 inhibitors with picomolar potency.
Bioorganic & medicinal chemistry letters 2012;22(7):2594-7.
2012: Ning Shao; Christopher Sondey; Robert E West; Shirley M Williams; Ren-Long Wu; Robert Aslanian; Joyce Hwa; Jean E Lachowicz; Anandan Palani
Synthesis and structure-activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists.
Bioorganic & medicinal chemistry letters 2012;22(5):2075-8.
2011: Purakkattle Biju; Rema Bitar; Richard Chapman; Stephen Eckel; Xiomara Fernandez; Aileen House; George Kelly; Kevin McCormick; Robbie McLeod; Michelle Natiello; Jonathan Phillips; Daniel Prelusky; Daniel Solomon; Robert Aslanian; Michael Berlin; John C Anthes
Steroidal C-21 mercapto derivatives as dissociated steroids: discovery of an inhaled dissociated steroid.
Bioorganic & medicinal chemistry letters 2011;21(21):6343-7.
2009: Robert Aslanian; John J Piwinski; Xiaohong Zhu; Tony Priestley; Steve Sorota; Xiao-Yi Du; Xue-Song Zhang; Robbie L McLeod; Robert E West; Shirley M Williams; John A Hey
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Bioorganic & medicinal chemistry letters 2009;19(17):5043-7.
2009: Tze-Ming Chan; Birendra Pramanik; Robert Aslanian; Vincent Gullo; Mahesh Patel; Bart Cronin; Chris Boyce; Kevin McCormick; Mike Berlin; Xiaohong Zhu; Alexei Buevich; Larry Heimark; Peter Bartner; Guodong Chen; Haiyan Pu; Vinod R Hegde
Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing.
Journal of pharmaceutical and biomedical analysis 2009;49(2):327-32.
2009: Xianhai Huang; Ning Shao; Robert Huryk; Anandan Palani; Robert Aslanian; Cynthia Seidel-Dugan
The discovery of potent antitumor agent C11-deoxypsymberin/irciniastatin A: total synthesis and biology of advanced psymberin analogs.
Organic letters 2009;11(4):867-70.
2009: Dong Xiao; Anandan Palani; Robert Aslanian; Brian A McKittrick; Andrew T McPhail; Craig C Correll; P Tara Phelps; John C Anthes; Diane Rindgen
Spiro-piperidine azetidinones as potent TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2009;19(3):783-7.
2008: Hongwu Wang; Robert Aslanian; Vincent S Madison
Induced-fit docking of mometasone furoate and further evidence for glucocorticoid receptor 17alpha pocket flexibility.
Journal of molecular graphics & modelling 2008;27(4):512-21.
2008: Robert Aslanian; Xiaohong Zhu; Henry A Vaccaro; Neng-Yang Shih; John J Piwinski; Shirley M Williams; Robert E West
Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.
Bioorganic & medicinal chemistry letters 2008;18(18):5032-6.
2007: Rongze Kuang; Ho-Jane Shue; David J Blythin; Neng-Yang Shih; Danlin Gu; Xiao Chen; John H Schwerdt; Ling Lin; Pauline C Ting; Xiaohong Zhu; Robert Aslanian; John J Piwinski; Li Xiao; Daniel Prelusky; Ping Wu; Ji Zhang; Xiang Zhang; Chander Celly; Michael Minnicozzi; Motasim Billah; Peng Wang
Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(18):5150-4.
2007: Xianhai Huang; Ning Shao; Anandan Palani; Robert Aslanian; Alexei V Buevich
The total synthesis of psymberin.
Organic letters 2007;9(13):2597-600.
2006: Michael Berlin; Pauline C Ting; Wayne D Vaccaro; Robert Aslanian; Kevin D McCormick; Joe F Lee; Margaret M Albanese; Mwangi wa Mutahi; John J Piwinski; Neng-Yang Shih; Luli Duguma; Daniel M Solomon; Wei Zhou; Rosy Sher; Leonard Favreau; Matthew Bryant; Walter A Korfmacher; Cymbylene Nardo; Robert E West; John C Anthes; Shirley M Williams; Ren-Long Wu; H Susan She; Maria A Rivelli; Michel R Corboz; John A Hey
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(4):989-94.
2006: Wayne D Vaccaro; Rosy Sher; Michael Berlin; Neng-Yang Shih; Robert Aslanian; John H Schwerdt; Kevin D McCormick; John J Piwinski; Robert E West; John C Anthes; Shirley M Williams; Ren-Long Wu; H Susan She; Maria A Rivelli; Jennifer C Mutter; Michel R Corboz; John A Hey; Leonard Favreau
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Bioorganic & medicinal chemistry letters 2006;16(2):395-9.
2005: Pauline C Ting; Shelby P Umland; Robert Aslanian; Jianhua Cao; Charles G Garlisi; Ying Huang; James Jakway; Zhidan Liu; Himanshu Shah; Fang Tian; Yuntao Wan; Neng-Yang Shih
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
Bioorganic & medicinal chemistry letters 2005;15(12):3020-3.
2005: Pauline C Ting; Joe F Lee; Jie Wu; Shelby P Umland; Robert Aslanian; Jianhua Cao; Youhao Dong; Charles G Garlisi; Eric J Gilbert; Ying Huang; James Jakway; Joseph Kelly; Zhidan Liu; Stuart W McCombie; Himanshu Shah; Fang Tian; Yuntao Wan; Neng-Yang Shih
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(5):1375-8.
2004: Xianhai Huang; Anandan Palani; Dong Xiao; Robert Aslanian; Neng-Yang Shih
Manipulation of N,O-nucleophilicity: efficient formation of 4-N-substituted 2,4-dihydro-3H-1,2,4-triazolin-3-ones.
Organic letters 2004;6(25):4795-8.
2003: Robert Aslanian; Mwangi wa Mutahi; Neng-Yang Shih; John J Piwinski; Robert West; Shirley M Williams; Susan She; Ren-Long Wu; John A Hey
Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.
Bioorganic & medicinal chemistry letters 2003;13(12):1959-61.
2003: Robbie L McLeod; Charles A Rizzo; Robert E West; Robert Aslanian; Kevin D McCormick; Matthew Bryant; Yunsheng Hsieh; Walter A Korfmacher; Garfield G Mingo; LoriAnn M Varty; Shirley M Williams; Neng-Yang Shih; Robert W Egan; John A Hey
Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).
The Journal of pharmacology and experimental therapeutics 2003;305(3):1037-44.
2002: Richard Yang; John A Hey; Robert Aslanian; Charles A Rizzo
Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes.
Pharmacology 2002;66(3):128-35.
2002: Pauline C Ting; Joe Lee; Margaret M Albanese; Wing Tom; Daniel Solomon; Robert Aslanian; Neng-Yang Shih; Robert West
The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(18):2643-6.
2002: Robert Aslanian; Mwangi wa Mutahi; Neng-Yang Shih; Kevin D McCormick; John J Piwinski; Pauline C Ting; Margaret M Albanese; Michael Berlin; Xiaohong Zhu; Shing-Chung Wong; Stuart B Rosenblum; Yueheng Jiang; Robert West; Susan She; Shirley M Williams; Matthew Bryant; John A Hey
Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.
Bioorganic & medicinal chemistry letters 2002;12(6):937-41.
2002: Gregory A Reichard; James Spitler; Robert Aslanian; Mwangi wa Mutahi; Neng-Yang Shih; Ling Lin; Pauline C Ting; John C Anthes; John J Piwinski
Structure-activity relationships of oxime neurokinin antagonists: oxime modifications.
Bioorganic & medicinal chemistry letters 2002;12(5):833-6.
2000: Gregory A Reichard; Z T Ball; Robert Aslanian; John C Anthes; Neng-Yang Shih; John J Piwinski
The design and synthesis of novel NK1/NK2 dual antagonists.
Bioorganic & medicinal chemistry letters 2000;10(20):2329-32.
1998: Robbie L McLeod; Robert Aslanian; M del Prado; Ruth A Duffy; Robert W Egan; William Kreutner; R McQuade; John A Hey
Sch 50971, an orally active histamine H3 receptor agonist, inhibits central neurogenic vascular inflammation and produces sedation in the guinea pig.
The Journal of pharmacology and experimental therapeutics 1998;287(1):43-50.
1998: John A Hey; Robert Aslanian; Donald C Bolser; Richard W Chapman; Robert W Egan; Charles A Rizzo; Neng-Yang Shih; Xiomara Fernandez; Robbie L McLeod; Robert West; William Kreutner
Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971.
Arzneimittel-Forschung 1998;48(9):881-8.
1998: Robert Aslanian; J E Brown; Neng-Yang Shih; M wa Mutahi; MJ Green; Susan She; M Del Prado; Robert West; J Hey
4-[(1H-imidazol-4-yl) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor.
Bioorganic & medicinal chemistry letters 1998;8(16):2263-8.
1998: Neng-Yang Shih; Robert Aslanian; A T Lupo; S Orlando; John J Piwinski; MJ Green; Ashit K Ganguly; Robert West; S Tozzi; William Kreutner; John A Hey
Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo.
Bioorganic & medicinal chemistry letters 1998;8(3):243-8.
1995: Neng-Yang Shih; A T Lupo; Robert Aslanian; S Orlando; John J Piwinski; M J Green; Ashit K Ganguly; M A Clark; S Tozzi; William Kreutner
A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist.
Journal of medicinal chemistry 1995;38(10):1593-9.