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Ann Hessell

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TOP 3
Brian Moldt; Falk Nimmerjahn; Paul W H I Parren; Pascal Poignard; Eva G Rakasz; Jörn E Schmitz; Niccole Schultz; Mami Shibata-Koyama; David Watkins; Anne-Sophie Dugast; D Cameron Dunlop; David T Evans; Samantha L Finstad; Donald N Forthal; Ann J Hessell; Shigeru Iida; Chenggang Jin; Yutaka Kanda; Gary Landucci; Michael D Alpert; Galit Alter; Dennis R Burton
A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques.
Marinieve Montero; Emil F Pai; Sue Tsai; Shixia Wang; Sampson Wu; Dennis R Burton; William F Degrado; Jason E Donald; Naveed Gulzar; Ann J Hessell; Jean-Philippe Julien; Kristina-Ana Klaric; Christa Lepik; Shan Lu; Jamie K Scott
Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.
Ann J Hessell; Nancy Haigwood
Neutralizing antibodies and control of HIV: moves and countermoves.

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All Publications

2012: Brian Moldt; Falk Nimmerjahn; Paul W H I Parren; Pascal Poignard; Eva G Rakasz; Jörn E Schmitz; Niccole Schultz; Mami Shibata-Koyama; David Watkins; Anne-Sophie Dugast; D Cameron Dunlop; David T Evans; Samantha L Finstad; Donald N Forthal; Ann J Hessell; Shigeru Iida; Chenggang Jin; Yutaka Kanda; Gary Landucci; Michael D Alpert; Galit Alter; Dennis R Burton
A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques.
Journal of virology 2012;86(11):6189-96.
2012: Marinieve Montero; Emil F Pai; Sue Tsai; Shixia Wang; Sampson Wu; Dennis R Burton; William F Degrado; Jason E Donald; Naveed Gulzar; Ann J Hessell; Jean-Philippe Julien; Kristina-Ana Klaric; Christa Lepik; Shan Lu; Jamie K Scott
Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.
Journal of virology 2012;86(6):2930-41.
2012: Ann J Hessell; Nancy Haigwood
Neutralizing antibodies and control of HIV: moves and countermoves.
Current HIV/AIDS reports 2012;9(1):64-72.
2011: Brian Moldt; Pascal Poignard; Niccole Schultz; Michael D Alpert; D Cameron Dunlop; David T Evans; Jackson D Harvey; Ann J Hessell; Dennis R Burton
A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV.
Journal of virology 2011;85(20):10572-81.
2011: Dennis R Burton; Lisa Cavacini; Lara A Doyle; D Cameron Dunlop; Ann J Hessell; Brandon F Keele; Thomas A Ketas; Per Johan Klasse; Brian Moldt; Pascal Poignard; Ronald S Veazey; John P Moore
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(27):11181-6.
2011: Kyriacos C Nicolaou; Silvano Sanchini; David Sarlah; Gang Lu; T Robert Wu; Daniel K. Nomura; Benjamin F Cravatt; Beatrice Cubitt; Juan Carlos de la Torre; Ann J Hessell; Dennis R Burton
Design, synthesis, and biological evaluation of a biyouyanagin compound library.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6715-20.
2011: Jason T Weinfurter; Gemma E May; Taeko Soma; Ann J Hessell; Enrique J León; Caitlin E Macnair; Shari M Piaskowski; Kim Weisgrau; Jessica Furlott; Nicholas J Maness; Jason Reed; Nancy A Wilson; Eva G Rakasz; Dennis R Burton; Thomas C Friedrich
Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus.
Journal of virology 2011;85(1):530-41.
2010: Matthew R Reynolds; Andrea M Weiler; Shari M Piaskowski; Holly L Kolar; Ann J Hessell; Madelyn Weiker; Kim L Weisgrau; Enrique J León; W Eric Rogers; Robert Makowsky; Adrian B McDermott; Rosanne Boyle; Nancy A Wilson; David Allison; Dennis R Burton; Wayne C Koff; David Ian Watkins
Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge.
Journal of virology 2010;84(18):9190-9.
2010: Evelien M Bunnik; Marit J van Gils; Marilie S D Lobbrecht; Linaida Pisas; Nening M Nanlohy; Debbie Van Baarle; Ad C van Nuenen; Ann J Hessell; Hanneke Schuitemaker
Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure.
The Journal of general virology 2010;91(Pt 5):1354-64.
2010: Ann J Hessell; Eva G Rakasz; David M Tehrani; Michael Huber; Kimberly L Weisgrau; Gary Landucci; Donald N Forthal; Wayne C Koff; Pascal Poignard; David Ian Watkins; Dennis R Burton
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L.
Journal of virology 2010;84(3):1302-13.
2009: Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science (New York, N.Y.) 2009;326(5956):1123-7.
2009: Jeffrey E Lee; Marnie L Fusco; Dafna M Abelson; Ann J Hessell; Dennis R Burton; Erica Ollmann Saphire
Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 11):1162-80.
2009: Ann J Hessell; Pascal Poignard; Meredith Hunter; Lars Hangartner; David M Tehrani; Wim K Bleeker; Paul W H I Parren; Preston A Marx; Dennis R Burton
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.
Nature medicine 2009;15(8):951-4.
2009: Ann J Hessell; Eva G Rakasz; Pascal Poignard; Lars Hangartner; Gary Landucci; Donald N Forthal; Wayne C Koff; David Ian Watkins; Dennis R Burton
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers.
PLoS pathogens 2009;5(5):e1000433.
2008: Jeffrey E Lee; Marnie L Fusco; Ann J Hessell; Wendelien B Oswald; Dennis R Burton; Erica Ollmann Saphire
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature 2008;454(7201):177-82.
2007: Ann J Hessell; Lars Hangartner; Meredith Hunter; Carin E G Havenith; Frank J Beurskens; Joost M Bakker; Caroline Lanigan; Gary Landucci; Donald N Forthal; Paul W H I Parren; Preston A Marx; Dennis R Burton
Fc receptor but not complement binding is important in antibody protection against HIV.
Nature 2007;449(7158):101-4.
2007: Nicholas J Mantis; Jana Palaia; Ann J Hessell; Simren Mehta; Zhiyi Zhu; Blaise Corthésy; Marian R Neutra; Dennis R Burton; Edward janoff
Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3144-52.
2007: John V Williams; Zhifeng Chen; Gabriella Cseke; David W Wright; Christopher Jay Keefer; Sharon J Tollefson; Ann J Hessell; Amy Podsiad; Bryan E Shepherd; Pietro Paolo Sanna; Dennis R Burton; James Crowe; R Anthony Williamson
A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo.
Journal of virology 2007;81(15):8315-24.
2007: Josh D Nelson; Florence Brunel; Richard Jensen; Emma T Crooks; Rosa M F Cardoso; Meng Wang; Ann J Hessell; Ian A Wilson; James M Binley; Philip E Dawson; Dennis R Burton; Michael B Zwick
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
Journal of virology 2007;81(8):4033-43.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2002: Felix Meissner; Toshiaki Maruyama; Marco Frentsch; Ann J Hessell; Luis L Rodriguez; Thomas W Geisbert; Peter B Jahrling; Dennis R Burton; Paul W H I Parren
Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay.
Virology 2002;300(2):236-43.
2001: M Hezareh; Ann J Hessell; R C Jensen; J G van de Winkel; Paul W H I Parren
Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1.
Journal of virology 2001;75(24):12161-8.
2001: Paul W H I Parren; Preston A Marx; Ann J Hessell; Amara Luckay; Janet M Harouse; Cecilia Cheng-Mayer; John P Moore; Dennis R Burton
Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro.
Journal of virology 2001;75(17):8340-7.
2000: Lucy Dorrell; Ann J Hessell; Meng Wang; Hilton Whittle; Saihou Sabally; Sarah Rowland-Jones; Dennis R Burton; Paul W H I Parren
Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia.
AIDS (London, England) 2000;14(9):1117-22.