FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Martin Hewison

Research Profile

Chemicals & Drugs

Anatomy

Procedures

Reverse Transcriptase Polymerase Chain Reaction

Physiology

Disorders

Vitamin D Deficiency

Co-author Network

Publications

TOP 3
Thomas S Lisse; Sandra Rieger; John S Adams; Rene F Chun; Martin Hewison
Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts.
Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Justine Bacchetta; Rene F Chun; Barbara Gales; Thomas S Lisse; Isidro B Salusky; Jessica L Sea; Katherine Wesseling-Perry; John S Adams; Martin Hewison
Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Martin Hewison (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Thomas S Lisse; Sandra Rieger; John S Adams; Rene F Chun; Martin Hewison
Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(6):1478-88.
2013: Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Science (New York, N.Y.) 2013;339(6126):1448-53.
2013: Justine Bacchetta; Rene F Chun; Barbara Gales; Thomas S Lisse; Isidro B Salusky; Jessica L Sea; Katherine Wesseling-Perry; John S Adams; Martin Hewison
Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):46-55.
2012: John S Adams; Martin Hewison
Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.
Archives of biochemistry and biophysics 2012;523(1):95-102.
2012: Mohammad M Ahasan; Cécile Bénézech; Christopher D Buckley; Jorge H Caamaño; Andrew R Clark; Andrew Filer; Rowan Hardy; Zaki Hassan-Smith; Martin Hewison; Christopher Jones; Maria Juarez; Kirren Kaur; Gareth Lavery; Stuart A Morgan; Dominika Nanus; Elizabeth H Rabbitt; Karim Raza; Paul M Stewart; Mark S Cooper
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells.
Arthritis and rheumatism 2012;64(7):2404-13.
2012: Nancy Q Liu; Martin Hewison
Vitamin D, the placenta and pregnancy.
Archives of biochemistry and biophysics 2012;523(1):37-47.
2012: Martin Hewison
Vitamin D and immune function: autocrine, paracrine or endocrine?
Scandinavian journal of clinical and laboratory investigation. Supplementum 2012;243():92-102.
2012: Martin Hewison
An update on vitamin D and human immunity.
Clinical endocrinology 2012;76(3):315-25.
2012: Martin Hewison
Vitamin D and the immune system: new perspectives on an old theme.
Rheumatic diseases clinics of North America 2012;38(1):125-39.
2012: Martin Hewison
Vitamin D and immune function: an overview.
The Proceedings of the Nutrition Society 2012;71(1):50-61.
2012: Rene F Chun; John S Adams; Bradford E Peercy; Martin Hewison
Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling.
PloS one 2012;7(1):e30773.
2011: Venu Lagishetty; Nancy Q Liu; Martin Hewison
Vitamin D metabolism and innate immunity.
Molecular and cellular endocrinology 2011;347(1-2):97-105.
2011: Mario Fabri; Martin Hewison; Bruce W Hollis; Shankar S Iyer; Eun-Kyeong Jo; Stephan R Krutzik; Hye-Mi Lee; David M Lewinsohn; Philip T Liu; Dennis Montoya; Susan Realegeno; Mirjam Schenk; Dong-Min Shin; Peter Allan Sieling; Andreas Steinmeyer; Steffen Stenger; Rosane M B Teles; Jae-Min Yuk; Ulrich Zügel; John S Adams; Barry R Bloom; Heiko Bruns; Genhong Cheng; Robert L Modlin
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.
Science translational medicine 2011;3(104):104ra102.
2011: Thomas S Lisse; Martin Hewison
Vitamin D: a new player in the world of mTOR signaling.
Cell cycle (Georgetown, Tex.) 2011;10(12):1888-9.
2011: Martin Hewison
Antibacterial effects of vitamin D.
Nature reviews. Endocrinology 2011;7(6):337-45.
2011: Nancy Q Liu; Amber Kaplan; Venu Lagishetty; Yuxin B Ouyang; Yi Ouyang; Charles F Simmons; Ozlem Equils; Martin Hewison
Vitamin D and the regulation of placental inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5968-74.
2011: Thomas S Lisse; Martin Hewison; John S Adams
Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling.
Steroids 2011;76(4):331-9.
2011: Thomas S Lisse; Ting Liu; Martin Irmler; Johannes Beckers; Hong Chen; John S Adams; Martin Hewison
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(3):937-47.
2011: Julia Lepenies; Paul M Stewart; Paul Cockwell; Kevin S Eardley; Martin Hewison; Thomas Ihl; Tina Kienitz; Marcus Quinkler
Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease.
Nephron. Clinical practice 2011;119(2):c97-c104.
2010: Kristina Edfeldt; Philip T Liu; Rene Chun; Mario Fabri; Mirjam Schenk; Matthew Wheelwright; Caroline Keegan; Stephan R Krutzik; John S Adams; Martin Hewison; Robert L Modlin
T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22593-8.
2010: Julia Lepenies; Martin Hewison; Paul M Stewart; Marcus Quinkler
Renal PPARγ mRNA expression increases with impairment of renal function in patients with chronic kidney disease.
Nephrology (Carlton, Vic.) 2010;15(7):683-91.
2010: Rene F Chun; Anna L Lauridsen; Lizabeth Suon; Lee A Zella; J Wesley Pike; Robert L Modlin; Adrian R Martineau; Robert J Wilkinson; John Adams; Martin Hewison
Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D.
The Journal of clinical endocrinology and metabolism 2010;95(7):3368-76.
2010: Venu Lagishetty; Rene Chun; Nancy Q Liu; Thomas S Lisse; John S Adams; Martin Hewison
1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines.
The Journal of steroid biochemistry and molecular biology 2010;121(1-2):228-33.
2010: Ozlem Equils; Martin Hewison
A role for vitamin D in placental immunology.
The Journal of infectious diseases 2010;201(12):1950-1; author reply 1951.
2010: Martin Hewison
Vitamin D and the intracrinology of innate immunity.
Molecular and cellular endocrinology 2010;321(2):103-11.
2010: Martin Hewison
Vitamin D and the immune system: new perspectives on an old theme.
Endocrinology and metabolism clinics of North America 2010;39(2):365-79, table of contents.
2010: Venu Lagishetty; Alexander Misharin; Nancy Q Liu; Thomas S Lisse; Rene Chun; Yi Ouyang; Sandra M McLachlan; John S Adams; Martin Hewison
Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis.
Endocrinology 2010;151(6):2423-32.
2010: K Kaur; R Hardy; M M Ahasan; M Eijken; J P van Leeuwen; Andrew Filer; A M Thomas; Karim Raza; Christopher D Buckley; Paul M Stewart; Elizabeth H Rabbitt; Martin Hewison; Mark S Cooper
Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss.
Annals of the rheumatic diseases 2010;69(6):1185-90.
2010: John S Adams; Martin Hewison
Update in vitamin D.
The Journal of clinical endocrinology and metabolism 2010;95(2):471-8.
2010: Martin Hewison; John S Adams
Vitamin D insufficiency and skeletal development in utero.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(1):11-3.
2009: Louisa E Jeffery; Fiona Burke; Manuela Mura; Yong Zheng; Omar Qureshi; Martin Hewison; Lucy S K Walker; David A Lammas; Karim Raza; David M Sansom
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5458-67.
2009: Dennis Montoya; Daniel Cruz; Rosane M B Teles; Delphine J Lee; Maria Teresa Ochoa; Stephan R Krutzik; Rene Chun; Mirjam Schenk; Xiaoran Zhang; Benjamin G Ferguson; Anne E Burdick; Euzenir N Sarno; Thomas H Rea; Martin Hewison; John S Adams; Genhong Cheng; Robert L Modlin
Divergence of macrophage phagocytic and antimicrobial programs in leprosy.
Cell host & microbe 2009;6(4):343-53.
2009: Hong Chen; Thomas Landes Clemens; Martin Hewison; John S Adams
Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro.
Endocrinology 2009;150(5):2429-35.
2009: John S Adams; Songyang Ren; Philip T Liu; Rene Chun; Venu Lagishetty; Adrian F Gombart; Niels Borregaard; Robert L Modlin; Martin Hewison
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4289-95.
2009: N Liu; Amber Kaplan; J Low; Laurent Nguyen; G Y Liu; Ozlem Equils; Martin Hewison
Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway.
Biology of reproduction 2009;80(3):398-406.
2009: Alexander Misharin; Martin Hewison; Chun-Rong Chen; Venu Lagishetty; Holly Aliesky; Yumiko Mizutori; Basil Rapoport; Sandra M McLachlan
Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization.
Endocrinology 2009;150(2):1051-60.
2009: Ava Masoumi; Ben Goldenson; Senait Ghirmai; Hripsime Avagyan; Justin Zaghi; Ken Abel; Xueying Zheng; Araceli Espinosa-Jeffrey; Michelle Mahanian; Phillip T Liu; Martin Hewison; Matthew Mizwickie; John Cashman; Milan Fiala
1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD 2009;17(3):703-17.
2008: Stephan R Krutzik; Martin Hewison; Philip T Liu; Juan Antonio Robles; Steffen Stenger; John S Adams; Robert L Modlin
IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7115-20.
2008: Daniel Zehnder; Marcus Quinkler; Kevin S Eardley; Rosemary Bland; Julia Lepenies; Susan V Hughes; Neil T Raymond; Alexander J Howie; Paul Cockwell; Paul M Stewart; Martin Hewison
Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation.
Kidney international 2008;74(10):1343-53.
2008: Nancy Liu; Lisa Nguyen; Rene F Chun; Venu Lagishetty; Songyang Ren; Shaoxing Wu; Bruce W Hollis; Hector F Deluca; John S Adams; Martin Hewison
Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation.
Endocrinology 2008;149(10):4799-808.
2008: R Hardy; Elizabeth H Rabbitt; A Filer; P Emery; Martin Hewison; Paul M Stewart; N J L Gittoes; Christopher D Buckley; K Raza; Mark S Cooper
Local and systemic glucocorticoid metabolism in inflammatory arthritis.
Annals of the rheumatic diseases 2008;67(9):1204-10.
2008: Rene F Chun; John S Adams; Martin Hewison
Back to the future: a new look at 'old' vitamin D.
The Journal of endocrinology 2008;198(2):261-9.
2008: Martin Hewison
Vitamin D and innate immunity.
Current opinion in investigational drugs (London, England : 2000) 2008;9(5):485-90.
2008: John S Adams; Martin Hewison
Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity.
Nature clinical practice. Endocrinology & metabolism 2008;4(2):80-90.
2007: John S Adams; Hong Chen; Rene Chun; Songyang Ren; Shaoxing Wu; Mercedes A Gacad; Lisa Nguyen; Jonathan Ride; Philip Liu; Robert Modlin; Martin Hewison
Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22 Suppl 2():V20-4.
2007: John S Adams; Philip T Liu; Rene Chun; Robert L Modlin; Martin Hewison
Vitamin D in defense of the human immune response.
Annals of the New York Academy of Sciences 2007;1117():94-105.
2007: Junny Chan; Elizabeth H Rabbitt; Barbara A Innes; Judith N Bulmer; Paul M Stewart; Mark D Kilby; Martin Hewison
Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation.
The Journal of endocrinology 2007;195(1):7-15.
2007: Rene Chun; Mercedes A Gacad; Lisa Nguyen; Martin Hewison; John S Adams
Co-chaperone potentiation of vitamin D receptor-mediated transactivation: a role for Bcl2-associated athanogene-1 as an intracellular-binding protein for 1,25-dihydroxyvitamin D3.
Journal of molecular endocrinology 2007;39(2):81-9.
2007: Shaoxing Wu; Songyang Ren; Lisa Nguyen; John S Adams; Martin Hewison
Splice variants of the CYP27b1 gene and the regulation of 1,25-dihydroxyvitamin D3 production.
Endocrinology 2007;148(7):3410-8.
2007: Martin Hewison; Fiona Burke; Katie N Evans; David A Lammas; David M Sansom; Philip Liu; Robert L Modlin; John S Adams
Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):316-21.
2007: Daniel Zehnder; Martin J Landray; David C Wheeler; William Fraser; Lisa Blackwell; Sarah Nuttall; Sue V Hughes; Jonathan N Townend; Charles Ferro; Colin Baigent; Martin Hewison
Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study.
Nephron. Clinical practice 2007;107(3):c109-16.
2006: Hong Chen; Martin Hewison; John S Adams
Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein.
The Journal of biological chemistry 2006;281(51):39114-20.
2006: Katie N Evans; Lisa Nguyen; Junny Chan; Barbara A Innes; Judith N Bulmer; Mark D Kilby; Martin Hewison
Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells.
Biology of reproduction 2006;75(6):816-22.
2006: Philip T Liu; Steffen Stenger; Huiying Li; Linda Wenzel; Belinda H Tan; Stephan R Krutzik; Maria Teresa Ochoa; Jürgen Schauber; Kent Wu; Christoph Meinken; Diane L Kamen; Manfred Wagner; Robert Bals; Andreas Steinmeyer; Ulrich Zügel; Richard L Gallo; David Eisenberg; Martin Hewison; Bruce W Hollis; John S Adams; Barry R Bloom; Robert L Modlin
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science (New York, N.Y.) 2006;311(5768):1770-3.
2006: Kelly Towsend; Victor Trevino; Francesco Falciani; Paul M Stewart; Martin Hewison; Moray J Campbell
Identification of VDR-responsive gene signatures in breast cancer cells.
Oncology 2006;71(1-2):111-23.
2006: Rowan S Hardy; Andrew Filer; Mark S Cooper; Greg Parsonage; Karim Raza; Debbie L Hardie; Elizabeth H Rabbitt; Paul M Stewart; Christopher D Buckley; Martin Hewison
Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation.
Arthritis research & therapy 2006;8(4):R108.
2005: Rene Chun; Mercedes A Gacad; Martin Hewison; John S Adams
Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones.
Endocrinology 2005;146(12):5540-4.
2005: Marcus Quinkler; Iwona J Bujalska; Kirren Kaur; Claire U Onyimba; Sabine Buhner; Bruno Allolio; Susan V Hughes; Martin Hewison; Paul M Stewart
Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney.
Hypertension 2005;46(4):787-98.
2005: Kelly Townsend; Katie N Evans; Moray J Campbell; Kay W Colston; John S Adams; Martin Hewison
Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):103-9.
2005: Lisa Freeman; Martin Hewison; Susan V Hughes; Katie N Evans; Deborah Hardie; Terry K Means; Ronjon Chakraverty
Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells.
Blood 2005;106(6):2042-9.
2005: Marcus Quinkler; Daniel Zehnder; Kevin S Eardley; Julia Lepenies; Alexander J Howie; Susan V Hughes; Paul Cockwell; Martin Hewison; Paul M Stewart
Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria.
Circulation 2005;112(10):1435-43.
2005: Marcus Quinkler; Daniel Zehnder; Julia Lepenies; Massimiliano D Petrelli; Jasbir S Moore; Susan V Hughes; Paul Cockwell; Martin Hewison; Paul M Stewart
Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):291-9.
2005: Songyang Ren; Lisa Nguyen; Shaoxing Wu; Carlos Encinas; John S Adams; Martin Hewison
Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis.
The Journal of biological chemistry 2005;280(21):20604-11.
2005: Kelly Townsend; Claire M Banwell; Michelle Guy; Kay W Colston; Janine L Mansi; Paul M Stewart; Moray J Campbell; Martin Hewison
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3579-86.
2005: Takashi Kumagai; Lee-Yung Shih; Susan V Hughes; Julian C Desmond; James O'Kelly; Martin Hewison; H Phillip Koeffler
19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.
Cancer research 2005;65(6):2488-97.
2004: Jeremy W Tomlinson; Elizabeth A Walker; Iwona J Bujalska; Nicole Draper; Gareth G Lavery; Mark S Cooper; Martin Hewison; Paul M Stewart
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Endocrine reviews 2004;25(5):831-66.
2004: Katie N Evans; Harris Taylor; Daniel Zehnder; Mark D Kilby; Judith N Bulmer; Farah Shah; John S Adams; Martin Hewison
Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy.
The American journal of pathology 2004;165(3):807-13.
2004: Wiebke Arlt; Martin Hewison
Hormones and immune function: implications of aging.
Aging cell 2004;3(4):209-16.
2004: Maria Abreu; Vitaly Kantorovich; Eric A Vasiliauskas; U Gruntmanis; Robin Matuk; K Daigle; S Chen; Daniel Zehnder; Y-C Lin; H Yang; Martin Hewison; John S Adams
Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
Gut 2004;53(8):1129-36.
2004: Katie N Evans; Judith N Bulmer; Mark D Kilby; Martin Hewison
Vitamin D and placental-decidual function.
Journal of the Society for Gynecologic Investigation 2004;11(5):263-71.
2004: John S Adams; Hong Chen; Rene Chun; Mercedes A Gacad; Carlos Encinas; Songyang Ren; Lisa Nguyen; Shaoxing Wu; Martin Hewison; Julia Barsony
Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):461-5.
2004: Rosemary Bland; danijela markovic; Claire E Hills; Susan V Hughes; Susan L F Chan; Paul E Squires; Martin Hewison
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):121-5.
2004: Martin Hewison; Daniel Zehnder; Ronjon Chakraverty; John S Adams
Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase.
Molecular and cellular endocrinology 2004;215(1-2):31-8.
2003: PM Driver; Saaeha Rauz; Elizabeth A Walker; Martin Hewison; Mark D Kilby; Paul M Stewart
Characterization of human trophoblast as a mineralocorticoid target tissue.
Molecular human reproduction 2003;9(12):793-8.
2003: Mark S Cooper; Aubrey Blumsohn; Philippa E Goddard; William A Bartlett; Cedric H L Shackleton; Ana Munoz; Martin Hewison; Paul M Stewart
11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone.
The Journal of clinical endocrinology and metabolism 2003;88(8):3874-7.
2003: Gareth G Lavery; Vanessa Ronconi; Nicole Draper; Elizabeth H Rabbitt; Val Lyons; Karen E Chapman; Elizabeth A Walker; Claire L McTernan; Gilberta Giacchetti; Franco Mantero; Jonathan R Seckl; Christopher R W Edwards; John M C Connell; Martin Hewison; Paul M Stewart
Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene.
Hypertension 2003;42(2):123-9.
2003: Nicole Draper; Elizabeth A Walker; Iwona J Bujalska; Jeremy W Tomlinson; Susan M Chalder; Wiebke Arlt; Gareth G Lavery; Oliver Bedendo; David W Ray; Ian Laing; Ewa M Malunowicz; Perrin C White; Martin Hewison; Philip Mason; John M C Connell; Cedric H L Shackleton; Paul M Stewart
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Nature genetics 2003;34(4):434-9.
2003: Elizabeth H Rabbitt; N J L Gittoes; Paul M Stewart; Martin Hewison
11beta-hydroxysteroid dehydrogenases, cell proliferation and malignancy.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):415-21.
2003: Martin Hewison; Lisa Freeman; Susan V Hughes; Katie N Evans; Rosemary Bland; Aristides G Eliopoulos; Mark D Kilby; Paul A H Moss; Ronjon Chakraverty
Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5382-90.
2003: Saaeha Rauz; Elizabeth A Walker; Susan V Hughes; Miguel Coca-Prados; Martin Hewison; Philip I Murray; Paul M Stewart
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.
Investigative ophthalmology & visual science 2003;44(4):1643-51.
2003: Elizabeth H Rabbitt; John Ayuk; Kristien Boelaert; Michael C Sheppard; Martin Hewison; Paul M Stewart; N J L Gittoes
Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation.
Oncogene 2003;22(11):1663-7.
2003: Martin Hewison; Vitaly Kantorovich; Harley R Liker; Andre J Van Herle; Pejman Cohan; Daniel Zehnder; John S Adams
Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(3):579-82.
2003: Julian C Desmond; joanne mountford; Mark T Drayson; Elizabeth A Walker; Martin Hewison; Jonathan P Ride; Quang T Luong; Rachel E Hayden; Elio F Vanin; Christopher M Bunce
The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.
Cancer research 2003;63(2):505-12.
2002: Jeremy W Tomlinson; B Sinha; Iwona J Bujalska; Martin Hewison; Paul M Stewart
Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
The Journal of clinical endocrinology and metabolism 2002;87(12):5630-5.
2002: Iwona J Bujalska; Elizabeth A Walker; Jeremy W Tomlinson; Martin Hewison; Paul M Stewart
11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
Endocrine research 2002;28(4):449-61.
2002: Nicole Draper; S M Echwald; Gareth G Lavery; Elizabeth A Walker; R Fraser; E Davies; Thorkild I A Sørensen; A Astrup; J Adamski; Martin Hewison; John M C Connell; O Pedersen; Paul M Stewart
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.
The Journal of clinical endocrinology and metabolism 2002;87(11):4984-90.
2002: Daniel Zehnder; Katie N Evans; Mark D Kilby; Judith N Bulmer; Barbara A Innes; Paul M Stewart; Martin Hewison
The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua.
The American journal of pathology 2002;161(1):105-14.
2002: Mark S Cooper; Elizabeth H Rabbitt; Philippa E Goddard; William A Bartlett; Martin Hewison; Paul M Stewart
Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(6):979-86.
2002: Gareth G Lavery; Claire L McTernan; Stephen C Bain; Tahseen A Chowdhury; Martin Hewison; Paul M Stewart
Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):553-8.
2002: Iwona J Bujalska; Elizabeth A Walker; Martin Hewison; Paul M Stewart
A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells.
The Journal of clinical endocrinology and metabolism 2002;87(3):1205-10.
2002: Daniel Zehnder; Rosemary Bland; Ravinder S Chana; David C Wheeler; Alexander J Howie; Mary C Williams; Paul M Stewart; Martin Hewison
Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion.
Journal of the American Society of Nephrology : JASN 2002;13(3):621-9.
2002: Elizabeth H Rabbitt; Gareth G Lavery; Elizabeth A Walker; Mark S Cooper; Paul M Stewart; Martin Hewison
Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):36-44.
2001: Claire L McTernan; Nicole Draper; H Nicholson; Susan M Chalder; PM Driver; Martin Hewison; Mark D Kilby; Paul M Stewart
Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms.
The Journal of clinical endocrinology and metabolism 2001;86(10):4979-83.
2001: Rosemary Bland; Daniel Zehnder; Susan V Hughes; Pierre M Ronco; Paul M Stewart; Martin Hewison
Regulation of vitamin D-1alpha-hydroxylase in a human cortical collecting duct cell line.
Kidney international 2001;60(4):1277-86.
2001: Saaeha Rauz; Elizabeth A Walker; Cedric H L Shackleton; Martin Hewison; Philip I Murray; Paul M Stewart
Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.
Investigative ophthalmology & visual science 2001;42(9):2037-42.
2001: Elizabeth A Walker; A M Clark; Martin Hewison; Jonathan P Ride; Paul M Stewart
Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.
The Journal of biological chemistry 2001;276(24):21343-50.
2001: Mark S Cooper; Iwona J Bujalska; Elizabeth H Rabbitt; Elizabeth A Walker; Rosemary Bland; Michael C Sheppard; Martin Hewison; Paul M Stewart
Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(6):1037-44.
2001: Jeremy W Tomlinson; J Moore; Mark S Cooper; Iwona J Bujalska; Mohsen Shahmanesh; C Burt; Alastair J Strain; Martin Hewison; Paul M Stewart
Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
Endocrinology 2001;142(5):1982-9.
2001: Martin Hewison; Mercedes A Gacad; J Lemire; John S Adams
Vitamin D as a cytokine and hematopoetic factor.
Reviews in endocrine & metabolic disorders 2001;2(2):217-27.
2001: PM Driver; Mark D Kilby; Iwona J Bujalska; Elizabeth A Walker; Martin Hewison; Paul M Stewart
Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies.
Molecular human reproduction 2001;7(4):357-63.
2001: Daniel Zehnder; Rosemary Bland; M C Williams; R W McNinch; Alexander J Howie; Paul M Stewart; Martin Hewison
Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase.
The Journal of clinical endocrinology and metabolism 2001;86(2):888-94.
2001: MA English; Paul M Stewart; Martin Hewison
Estrogen metabolism and malignancy: analysis of the expression and function of 17beta-hydroxysteroid dehydrogenases in colonic cancer.
Molecular and cellular endocrinology 2001;171(1-2):53-60.
2001: Rosemary Bland; Martin Hewison
Steroid hormone metabolites and hormone binding assays.
Methods in molecular biology (Clifton, N.J.) 2001;176():145-62.
2001: LJ Eyre; Elizabeth H Rabbitt; Rosemary Bland; Susan V Hughes; Mark S Cooper; Michael C Sheppard; Paul M Stewart; Martin Hewison
Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone.
Journal of cellular biochemistry 2001;81(3):453-62.
2000: Martin Hewison; Daniel Zehnder; Rosemary Bland; Paul M Stewart
1alpha-Hydroxylase and the action of vitamin D.
Journal of molecular endocrinology 2000;25(2):141-8.
2000: Mark S Cooper; Elizabeth A Walker; Rosemary Bland; W D Fraser; Martin Hewison; Paul M Stewart
Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone.
Bone 2000;27(3):375-81.
2000: MA English; Susan V Hughes; K F Kane; M J S Langman; Paul M Stewart; Martin Hewison
Oestrogen inactivation in the colon: analysis of the expression and regulation of 17beta-hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer.
British journal of cancer 2000;83(4):550-8.
2000: Rosemary Bland; Daniel Zehnder; Martin Hewison
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase along the nephron: new insights into renal vitamin D metabolism.
Current opinion in nephrology and hypertension 2000;9(1):17-22.
1999: Daniel Zehnder; Rosemary Bland; Elizabeth A Walker; Arthur R Bradwell; Alexander J Howie; Martin Hewison; Paul M Stewart
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney.
Journal of the American Society of Nephrology : JASN 1999;10(12):2465-73.
1999: Mark S Cooper; Martin Hewison; Paul M Stewart
Glucocorticoid activity, inactivity and the osteoblast.
The Journal of endocrinology 1999;163(2):159-64.
1999: Iwona J Bujalska; Sudhesh Kumar; Martin Hewison; Paul M Stewart
Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase.
Endocrinology 1999;140(7):3188-96.
1999: MA English; K F Kane; NR Cruickshank; M J S Langman; Paul M Stewart; Martin Hewison
Loss of estrogen inactivation in colonic cancer.
The Journal of clinical endocrinology and metabolism 1999;84(6):2080-5.
1999: Rosemary Bland; C A Worker; B S Noble; LJ Eyre; Iwona J Bujalska; Michael C Sheppard; Paul M Stewart; Martin Hewison
Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines.
The Journal of endocrinology 1999;161(3):455-64.
1999: Daniel Zehnder; Martin Hewison
The renal function of 25-hydroxyvitamin D3-1alpha-hydroxylase.
Molecular and cellular endocrinology 1999;151(1-2):213-20.
1999: Rosemary Bland; Elizabeth A Walker; Susan V Hughes; Paul M Stewart; Martin Hewison
Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium.
Endocrinology 1999;140(5):2027-34.
1999: joanne mountford; Christopher M Bunce; Susan V Hughes; Mark T Drayson; D Webb; Geoffrey Brown; Martin Hewison
Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.
Experimental hematology 1999;27(3):451-60.
1998: J Condon; Christine Gosden; Derek Gardener; P Nickson; Martin Hewison; Alexander J Howie; Paul M Stewart
Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life.
The Journal of clinical endocrinology and metabolism 1998;83(12):4490-7.
1998: M Dabrowski; E Robinson; Susan V Hughes; Rosemary Bland; Martin Hewison
Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression.
Molecular and cellular endocrinology 1998;142(1-2):131-9.
1998: LJ Eyre; Rosemary Bland; Iwona J Bujalska; Michael C Sheppard; Paul M Stewart; Martin Hewison
Characterization of aromatase and 17 beta-hydroxysteroid dehydrogenase expression in rat osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(6):996-1004.
1998: ML Ricketts; K J Shoesmith; Martin Hewison; Alastair J Strain; Sundaram Ramasamy; Paul M Stewart
Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes.
The Journal of endocrinology 1998;156(1):159-68.
1997: Susan V Hughes; E Robinson; Rosemary Bland; HM Lewis; Paul M Stewart; Martin Hewison
1,25-dihydroxyvitamin D3 regulates estrogen metabolism in cultured keratinocytes.
Endocrinology 1997;138(9):3711-8.
1997: Christopher M Bunce; Geoffrey Brown; Martin Hewison
Vitamin D and hematopoiesis.
Trends in endocrinology and metabolism: TEM 1997;8(6):245-51.
1997: Massimiliano D Petrelli; S S Lim-Tio; J Condon; Martin Hewison; Paul M Stewart
Differential expression of nuclear 11beta-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues.
Endocrinology 1997;138(7):3077-80.
1997: M Shimojo; ML Ricketts; Massimiliano D Petrelli; P Moradi; GD Johnson; Arthur R Bradwell; Martin Hewison; Alexander J Howie; Paul M Stewart
Immunodetection of 11 beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization.
Endocrinology 1997;138(3):1305-11.
1995: Martin Hewison
New trends in bone research.
Journal of the Royal College of Physicians of London 1995;29(5):383-7.