FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Erik Hewlett

Research Profile

Chemicals & Drugs

Living Beings

Disorders

Anatomy

Concepts & Ideas

Kinetics

Co-author Network

Publications

TOP 3
Joshua C Eby; Mary C Gray; James Bowden; Shandra R Day; Gina M Donato; Tara F Jones; Tod J Merkel; Christopher D Paddock; Melinda D Poulter; Jason M Warfel; Erik L Hewlett
Quantification of the Adenylate Cyclase Toxin of Bordetella pertussis In Vitro and during Respiratory Infection.
Arvind K Chavali; Kevin M D'Auria; Erik L Hewlett; Richard D Pearson; Jason A Papin
A metabolic network approach for the identification and prioritization of antimicrobial drug targets.
Gina M Donato; Joshua C Eby; Cynthia S Goldsmith; Mary C Gray; Christopher D Paddock; Erik L Hewlett
Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Erik Hewlett (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Joshua C Eby; Mary C Gray; James Bowden; Shandra R Day; Gina M Donato; Tara F Jones; Tod J Merkel; Christopher D Paddock; Melinda D Poulter; Jason M Warfel; Erik L Hewlett
Quantification of the Adenylate Cyclase Toxin of Bordetella pertussis In Vitro and during Respiratory Infection.
Infection and immunity 2013;81(5):1390-8.
2012: Arvind K Chavali; Kevin M D'Auria; Erik L Hewlett; Richard D Pearson; Jason A Papin
A metabolic network approach for the identification and prioritization of antimicrobial drug targets.
Trends in microbiology 2012;20(3):113-23.
2012: Gina M Donato; Joshua C Eby; Cynthia S Goldsmith; Mary C Gray; Christopher D Paddock; Erik L Hewlett
Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.
FEBS letters 2012;586(4):459-65.
2012: Joshua C Eby; Mary C Gray; Gina M Donato; Annabelle R Mangan; Erik L Hewlett
Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.
Infection and immunity 2012;80(2):850-9.
2012: Kevin M D'Auria; Gina M Donato; Mary C Gray; Glynis L Kolling; Joanne A Lannigan; Jason A Papin; Michael D Solga; Cirle A Warren; Lauren M Cave; Erik L Hewlett
Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.
BMC systems biology 2012;6():2.
2011: Mary C Gray; Erik L Hewlett
Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis.
Cellular microbiology 2011;13(1):123-34.
2010: Joshua C Eby; William P Ciesla; Wendy Hamman; Gina M Donato; Raymond J Pickles; Erik L Hewlett; Wayne I Lencer
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
The Journal of biological chemistry 2010;285(14):10662-70.
2007: Darren Perkins; Mary C Gray; Erik L Hewlett; Stefanie N Vogel
Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).
Molecular microbiology 2007;66(4):1003-15.
2007: Jeffrey Tessier; Candace Green; Diana Padgett; Wei Zhao; Lawrence Schwartz; Molly Hughes; Erik L Hewlett
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Infection and immunity 2007;75(4):1895-903.
2006: Christopher J Easley; James M Karlinsey; Joan M Bienvenue; Lindsay A Legendre; Michael G Roper; Sanford H Feldman; Molly A Hughes; Erik L Hewlett; Tod J Merkel; Jerome P Ferrance; James P Landers
A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19272-7.
2006: Erik L Hewlett; Gina M Donato; Mary C Gray
Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
Molecular microbiology 2006;59(2):447-59.
2005: Gina M Donato; Hung-Lun J Hsia; Candace S Green; Erik L Hewlett
Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.
Journal of bacteriology 2005;187(22):7579-88.
2005: Sang-Jin Lee; Mary C Gray; Kai Zu; Erik L Hewlett
Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution.
Archives of biochemistry and biophysics 2005;438(1):80-7.
2005: Erik L Hewlett; Kathryn M Edwards
Clinical practice. Pertussis--not just for kids.
The New England journal of medicine 2005;352(12):1215-22.
2004: Mary C Gray; Gina M Donato; F R Jones; T Kim; Erik L Hewlett
Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.
Molecular microbiology 2004;53(6):1709-19.
2002: Franca R Zaretzky; Mary C Gray; Erik L Hewlett
Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction.
Molecular microbiology 2002;45(6):1589-98.
2001: C R Rhodes; Mary C Gray; J M Watson; T L Muratore; S B Kim; Erik L Hewlett; C M Grisham
Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis.
Archives of biochemistry and biophysics 2001;395(2):169-76.
2001: Mary C Gray; Sang-Jin Lee; Lloyd S Gray; F R Zaretzky; AS Otero; Gabor Szabo; Erik L Hewlett
Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis.
Journal of bacteriology 2001;183(20):5904-10.
2000: CL Weingart; Paula S Mobberley-Schuman; Erik L Hewlett; Mary C Gray; Alison A Weiss
Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.
Infection and immunity 2000;68(12):7152-5.
2000: Erik L Hewlett; K J Kim; Sang-Jin Lee; Mary C Gray
Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions.
International journal of medical microbiology : IJMM 2000;290(4-5):333-5.
1999: Mary C Gray; W Ross; K Kim; Erik L Hewlett
Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry.
Infection and immunity 1999;67(9):4393-9.
1999: Erik L Hewlett
A commentary on the pathogenesis of pertussis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999;28 Suppl 2():S94-8.
1999: Sang-Jin Lee; Mary C Gray; L Guo; Peter Sebo; Erik L Hewlett
Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.
Infection and immunity 1999;67(5):2090-5.
1998: M Gray; Gabor Szabo; AS Otero; L Gray; Erik L Hewlett
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin.
The Journal of biological chemistry 1998;273(29):18260-7.
1997: Erik L Hewlett
Pertussis: current concepts of pathogenesis and prevention.
The Pediatric infectious disease journal 1997;16(4 Suppl):S78-84.
1995: M Hackett; C B Walker; L Guo; Mary C Gray; S Van Cuyk; Agnes Ullmann; Jeffrey Shabanowitz; Donald F Hunt; Erik L Hewlett; Peter Sebo
Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli.
The Journal of biological chemistry 1995;270(35):20250-3.
1995: AS Otero; X B Yi; Mary C Gray; Gabor Szabo; Erik L Hewlett
Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin.
The Journal of biological chemistry 1995;270(17):9695-7.
1994: M Hackett; L Guo; Jeffrey Shabanowitz; Donald F Hunt; Erik L Hewlett
Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.
Science (New York, N.Y.) 1994;266(5184):433-5.
1994: Gabor Szabo; Mary C Gray; Erik L Hewlett
Adenylate cyclase toxin from Bordetella pertussis produces ion conductance across artificial lipid bilayers in a calcium- and polarity-dependent manner.
The Journal of biological chemistry 1994;269(36):22496-9.
1994: K A Sindt; Erik L Hewlett; G T Redpath; R Rappuoli; Lloyd S Gray; Scott R Vandenberg
Pertussis toxin activates platelets through an interaction with platelet glycoprotein Ib.
Infection and immunity 1994;62(8):3108-14.
1993: Erik L Hewlett; Mary C Gray; I E Ehrmann; N J Maloney; AS Otero; L Gray; M Allietta; Gabor Szabo; A A Weiss; Eileen M Barry
Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.
The Journal of biological chemistry 1993;268(11):7842-8.
1992: I E Ehrmann; A A Weiss; M S Goodwin; Mary C Gray; Eileen M Barry; Erik L Hewlett
Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis.
FEBS letters 1992;304(1):51-6.
1991: Erik L Hewlett; L Gray; M Allietta; I Ehrmann; V M Gordon; Mary C Gray
Adenylate cyclase toxin from Bordetella pertussis. Conformational change associated with toxin activity.
The Journal of biological chemistry 1991;266(26):17503-8.
1991: I E Ehrmann; Mary C Gray; V M Gordon; Lloyd S Gray; Erik L Hewlett
Hemolytic activity of adenylate cyclase toxin from Bordetella pertussis.
FEBS letters 1991;278(1):79-83.
1991: Eileen M Barry; A A Weiss; I E Ehrmann; Mary C Gray; Erik L Hewlett; M S Goodwin
Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation.
Journal of bacteriology 1991;173(2):720-6.
1990: G W Sullivan; Joel Linden; Erik L Hewlett; H T Carper; John B Hylton; Gerald L Mandell
Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1537-44.
1990: C S Weikel; C L Spann; C P Chambers; J K Crane; Joel Linden; Erik L Hewlett
Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa).
Infection and immunity 1990;58(5):1402-7.
1989: Erik L Hewlett; V M Gordon; J D McCaffery; William M Sutherland; Mary C Gray
Adenylate cyclase toxin from Bordetella pertussis. Identification and purification of the holotoxin molecule.
The Journal of biological chemistry 1989;264(32):19379-84.
1989: V M Gordon; William W Young; S M Lechler; Mary C Gray; Stephen H Leppla; Erik L Hewlett
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
The Journal of biological chemistry 1989;264(25):14792-6.
1989: J K Crane; Erik L Hewlett; C S Weikel
Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line.
Infection and immunity 1989;57(4):1186-91.
1989: Erik L Hewlett; J L Cowell
Evaluation of the mouse model for study of encephalopathy in pertussis vaccine recipients.
Infection and immunity 1989;57(3):661-3.
1989: Lloyd S Gray; K S Huber; Mary C Gray; Erik L Hewlett; Victor H Engelhard
Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1631-8.
1988: M A McLafferty; D R Harcus; Erik L Hewlett
Nucleotide sequence and characterization of a repetitive DNA element from the genome of Bordetella pertussis with characteristics of an insertion sequence.
Journal of general microbiology 1988;134(8):2297-306.
1988: Johannes D Veldhuis; Raymond Rodgers; Erik L Hewlett
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):499-506.
1988: Lloyd S Gray; J Gnarra; Erik L Hewlett; Victor H Engelhard
Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms.
The Journal of experimental medicine 1988;167(6):1963-8.
1988: Louis M Luttrell; Erik L Hewlett; G Romero; A D Rogol
Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.
The Journal of biological chemistry 1988;263(13):6134-41.
1988: Y X He; Erik L Hewlett; D Temeles; Peter J Quesenberry
Inhibition of interleukin 3 and colony-stimulating factor 1-stimulated marrow cell proliferation by pertussis toxin.
Blood 1988;71(5):1187-95.
1988: V M Gordon; Stephen H Leppla; Erik L Hewlett
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
Infection and immunity 1988;56(5):1066-9.
1988: G Romero; Louis M Luttrell; A Rogol; K Zeller; Erik L Hewlett; James M Larner
Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.
Science (New York, N.Y.) 1988;240(4851):509-11.
1988: John N Galgiani; Erik L Hewlett; R L Friedman
Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus.
Infection and immunity 1988;56(4):751-5.
1988: Erik L Hewlett
Pertussis in adults: possible use of booster doses for control.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():125-8.
1987: Richard D Pearson; P Symes; M Conboy; A A Weiss; Erik L Hewlett
Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2749-54.