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Derren Heyes

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Marta Amaral; Flaviano Giorgini; Derren J Heyes; Pierre Lafite; Colin Levy; David Leys; Tiago Outeiro; Nigel S Scrutton
Structural basis of kynurenine 3-monooxygenase inhibition.
Nigel S Scrutton; Marie Louise Groot; Derren J Heyes
Excited state dynamics and catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase.
Christopher R Pudney; Stephen E J Rigby; sam hay; Derren J Heyes; Basile Khara; Nigel S Scrutton
Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.

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All Publications

2013: Marta Amaral; Flaviano Giorgini; Derren J Heyes; Pierre Lafite; Colin Levy; David Leys; Tiago Outeiro; Nigel S Scrutton
Structural basis of kynurenine 3-monooxygenase inhibition.
Nature 2013;496(7445):382-5.
2012: Nigel S Scrutton; Marie Louise Groot; Derren J Heyes
Excited state dynamics and catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase.
Physical chemistry chemical physics : PCCP 2012;14(25):8818-24.
2012: Christopher R Pudney; Stephen E J Rigby; sam hay; Derren J Heyes; Basile Khara; Nigel S Scrutton
Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.
The FEBS journal 2012;279(9):1534-44.
2012: Chandan Maitrani; Selvanathan Arumugam; Sam Hay; Derren J Heyes; Vladimir V Popik; Robert S Phillips
Preparation and photophysical properties of a caged kynurenine.
Bioorganic & medicinal chemistry letters 2012;22(8):2734-7.
2012: Nicole G H Leferink; Christopher R Pudney; Stephen E J Rigby; S Samar Hasnain; Sibylle Brenner; Robert R Eady; Sam Hay; Derren J Heyes; Nigel S Scrutton
Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.
FEBS letters 2012;586(5):578-84.
2012: Derren J Heyes; Basile Khara; Ronan O'Cualain; Stephen E J Rigby; Michiyo Sakuma; Samantha J O Hardman; Nigel S Scrutton
Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state.
PloS one 2012;7(12):e52418.
2012: Derren J Heyes; David Mansell; John M Gardiner; Samantha J O Hardman; Nigel S Scrutton
Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase.
PloS one 2012;7(9):e45642.
2012: Jacqueline Vieira; Taishi Yoshii; Jean-Yves Coppee; Antoine Danon; Charlotte Helfrich-Förster; Derren J Heyes; Nathalie Hoang; Alex R Jones; André Klarsfeld; Marie Picot; David Robles; François Rouyer; Michiyo Sakuma; Nigel S Scrutton; Guillaume Soubigou; Shirley Tait; Margaret Ahmad
Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability.
PloS one 2012;7(3):e31867.
2011: Svetlana Antonyuk; Jamie L Arnst; Neil G Berry; Robert R Eady; Derren J Heyes; Christine A Petersen; Neil Rustage; Nigel S Scrutton; Raman Sharma; Colin R Andrew; S Samar Hasnain
Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15780-5.
2011: Nicole G H Leferink; Cong Han; Svetlana V Antonyuk; Derren J Heyes; Stephen E J Rigby; Michael A Hough; Robert R Eady; Nigel S Scrutton; S Samar Hasnain
Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase.
Biochemistry 2011;50(19):4121-31.
2011: Derren J Heyes; Colin Levy; Michiyo Sakuma; David L Robertson; Nigel S Scrutton
A twin-track approach has optimized proton and hydride transfer by dynamically coupled tunneling during the evolution of protochlorophyllide oxidoreductase.
The Journal of biological chemistry 2011;286(13):11849-54.
2011: Olga A Sytina; Maxime T Alexandre; Derren J Heyes; C Neil Hunter; Bruno Robert; Rienk van Grondelle; Marie Louise Groot
Enzyme activation and catalysis: characterisation of the vibrational modes of substrate and product in protochlorophyllide oxidoreductase.
Physical chemistry chemical physics : PCCP 2011;13(6):2307-13.
2010: Olga A Sytina; Ivo H M van Stokkum; Derren J Heyes; C Neil Hunter; Rienk van Grondelle; Marie Louise Groot
Protochlorophyllide excited-state dynamics in organic solvents studied by time-resolved visible and mid-infrared spectroscopy.
The journal of physical chemistry. B 2010;114(12):4335-44.
2010: Binuraj R K Menon; Paul A Davison; C Neil Hunter; Nigel S Scrutton; Derren J Heyes
Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase.
The Journal of biological chemistry 2010;285(3):2113-9.
2009: Derren J Heyes; Colin Levy; Pierre Lafite; Ian S Roberts; Marie Goldrick; Andrew V Stachulski; Steven B Rossington; Deborah Stanford; Stephen E J Rigby; Nigel S Scrutton; David Leys
Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases.
The Journal of biological chemistry 2009;284(51):35514-23.
2009: Sibylle Brenner; Derren J Heyes; Sam Hay; Michael A Hough; Robert R Eady; S Samar Hasnain; Nigel S Scrutton
Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases.
The Journal of biological chemistry 2009;284(38):25973-83.
2009: Binuraj R K Menon; Jonathan P Waltho; Nigel S Scrutton; Derren J Heyes
Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase.
The Journal of biological chemistry 2009;284(27):18160-6.
2009: Olga A Sytina; Derren J Heyes; C Neil Hunter; Marie Louise Groot
Ultrafast catalytic processes and conformational changes in the light-driven enzyme protochlorophyllide oxidoreductase (POR).
Biochemical Society transactions 2009;37(Pt 2):387-91.
2009: Derren J Heyes; Nigel S Scrutton
Conformational changes in the catalytic cycle of protochlorophyllide oxidoreductase: what lessons can be learnt from dihydrofolate reductase?
Biochemical Society transactions 2009;37(Pt 2):354-7.
2009: Derren J Heyes; Anne-Marie Quinn; Paul M Cullis; Michael Lee; Andrew W Munro; Nigel S Scrutton
Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).
Chemical communications (Cambridge, England) 2009;(9):1124-6.
2009: Guillaume Durin; Aude Delaunay; Claudine Darnault; Derren J Heyes; Antoine Royant; Xavier Vernede; C Neil Hunter; Martin Weik; Dominique Bourgeois
Simultaneous measurements of solvent dynamics and functional kinetics in a light-activated enzyme.
Biophysical journal 2009;96(5):1902-10.
2009: Derren J Heyes; Michiyo Sakuma; Sam P de Visser; Nigel S Scrutton
Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase.
The Journal of biological chemistry 2009;284(6):3762-7.
2009: Derren J Heyes; Michiyo Sakuma; Nigel S Scrutton
Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase.
Angewandte Chemie (International ed. in English) 2009;48(21):3850-3.
2008: Derren J Heyes; Binuraj R K Menon; Michiyo Sakuma; Nigel S Scrutton
Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase.
Biochemistry 2008;47(41):10991-8.
2008: Colin Levy; Katharine Pike; Derren J Heyes; M Gordon Joyce; Krisztina Gabor; Hauke Smidt; John van der Oost; David Leys
Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator.
Molecular microbiology 2008;70(1):151-67.
2007: Derren J Heyes; Michiyo Sakuma; Nigel S Scrutton
Laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase.
The Journal of biological chemistry 2007;282(44):32015-20.
2007: Adrian J Dunford; Kirsty J McLean; Muna Sabri; Harriet E Seward; Derren J Heyes; Nigel S Scrutton; Andrew W Munro
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
The Journal of biological chemistry 2007;282(34):24816-24.
2007: Hazel M Girvan; Derren J Heyes; Nigel S Scrutton; Andrew W Munro
Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale.
Journal of the American Chemical Society 2007;129(20):6647-53.
2006: Derren J Heyes; Peter Heathcote; Stephen E J Rigby; Miguel A Palacios; Rienk van Grondelle; C Neil Hunter
The first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex.
The Journal of biological chemistry 2006;281(37):26847-53.
2006: Derren J Heyes; Jerzy Kruk; C Neil Hunter
Spectroscopic and kinetic characterization of the light-dependent enzyme protochlorophyllide oxidoreductase (POR) using monovinyl and divinyl substrates.
The Biochemical journal 2006;394(Pt 1):243-8.
2005: Michael J McFarlane; C Neil Hunter; Derren J Heyes
Kinetic characterisation of the light-driven protochlorophyllide oxidoreductase (POR) from Thermosynechococcus elongatus.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2005;4(12):1055-9.
2005: Derren J Heyes; C Neil Hunter
Making light work of enzyme catalysis: protochlorophyllide oxidoreductase.
Trends in biochemical sciences 2005;30(11):642-9.
2004: Derren J Heyes; C Neil Hunter
Identification and characterization of the product release steps within the catalytic cycle of protochlorophyllide oxidoreductase.
Biochemistry 2004;43(25):8265-71.
2003: Derren J Heyes; C Neil Hunter; Ivo H M van Stokkum; Rienk van Grondelle; Marie Louise Groot
Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase.
Nature structural biology 2003;10(6):491-2.
2003: Derren J Heyes; Alexander V Ruban; C Neil Hunter
Protochlorophyllide oxidoreductase: "dark" reactions of a light-driven enzyme.
Biochemistry 2003;42(2):523-8.
2002: Derren J Heyes; Alexander V Ruban; Helen M Wilks; C Neil Hunter
Enzymology below 200 K: the kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11145-50.
2002: Derren J Heyes; C Neil Hunter
Site-directed mutagenesis of Tyr-189 and Lys-193 in NADPH: protochlorophyllide oxidoreductase from Synechocystis.
Biochemical Society transactions 2002;30(4):601-4.
2000: Derren J Heyes; G E Martin; R J Reid; C Neil Hunter; Helen M Wilks
NADPH:protochlorophyllide oxidoreductase from Synechocystis: overexpression, purification and preliminary characterisation.
FEBS letters 2000;483(1):47-51.