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Clare Heyworth

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Yvonne J Summers; Clare Heyworth; Erika A de Wynter; Claire A Hart; James Chang; Nydia G Testa
AC133+ G0 cells from cord blood show a high incidence of long-term culture-initiating cells and a capacity for more than 100 million-fold amplification of colony-forming cells in vitro.
Ludovica Bruno; Reinhard Hoffmann; Fraser McBlane; John Brown; Rajeev Gupta; Chirag Joshi; Stella Pearson; Thomas Seidl; Clare Heyworth; Tariq Enver
Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro.
Clare Heyworth; Stella Pearson; Gillian May; Tariq Enver
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.

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2004: Yvonne J Summers; Clare Heyworth; Erika A de Wynter; Claire A Hart; James Chang; Nydia G Testa
AC133+ G0 cells from cord blood show a high incidence of long-term culture-initiating cells and a capacity for more than 100 million-fold amplification of colony-forming cells in vitro.
Stem cells (Dayton, Ohio) 2004;22(5):704-15.
2004: Ludovica Bruno; Reinhard Hoffmann; Fraser McBlane; John Brown; Rajeev Gupta; Chirag Joshi; Stella Pearson; Thomas Seidl; Clare Heyworth; Tariq Enver
Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro.
Molecular and cellular biology 2004;24(2):741-56.
2002: Clare Heyworth; Stella Pearson; Gillian May; Tariq Enver
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.
The EMBO journal 2002;21(14):3770-81.
2002: Clare Heyworth; D Gagen; K G Edington; Leslie J Fairbairn
Retroviral transfer and expression of human MDR-1 in a murine haemopoietic stem cell line does not alter factor dependence, growth or differentiation characteristics.
Leukemia 2002;16(1):106-11.
2001: Jun Zhu; Clare Heyworth; A Glasow; QH Huang; Kevin Petrie; Michel Lanotte; G Benoit; Robert E Gallagher; Samuel Waxman; Tariq Enver; Arthur Zelent
Lineage restriction of the RARalpha gene expression in myeloid differentiation.
Blood 2001;98(8):2563-7.
2001: Erika A de Wynter; Clare Heyworth; N Mukaida; E Jaworska; A Weffort-Santos; K Matushima; Nydia G Testa
CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors.
Journal of leukocyte biology 2001;70(3):455-60.
2001: Erika A de Wynter; Clare Heyworth; N Mukaida; K Matsushima; Nydia G Testa
NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor.
Leukemia 2001;15(7):1092-101.
2001: Janet W Baird; KM Ryan; I Hayes; Lynne Hampson; Clare Heyworth; A Clark; M Wootton; John D Ansell; U Menzel; Nicholas Hole; Gerard J Graham
Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells.
The Journal of biological chemistry 2001;276(12):9189-98.
2001: Reinhard Henschler; K E Appel; Clare Heyworth; H Glatt
Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(1):31-7.
2001: Y J Summers; Clare Heyworth; Erika A de Wynter; J Chang; Nydia G Testa
Cord blood G(0) CD34+ cells have a thousand-fold higher capacity for generating progenitors in vitro than G(1) CD34+ cells.
Stem cells (Dayton, Ohio) 2001;19(6):505-13.
2000: JM Francis; Clare Heyworth; Elaine Spooncer; Andrew Pierce; TM Dexter; Anthony D Whetton
Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.
The Journal of biological chemistry 2000;275(50):39137-45.
2000: Zoe McIvor; Clare Heyworth; B A Johnson; S Pearson; Heike Fiegler; Lynne Hampson; TM Dexter; Michael Cross
A transient assay for regulatory gene function in haemopoietic progenitor cells.
British journal of haematology 2000;110(3):674-81.
2000: Jan Dürig; C Rosenthal; Ahmet H Elmaagacli; Clare Heyworth; Katja Halfmeyer; Christoph Kasper; J Novotny; Ulrich Dührsen
Biological effects of stroma-derived factor-1 alpha on normal and CML CD34+ haemopoietic cells.
Leukemia 2000;14(9):1652-60.
2000: M Clemons; A Watson; A Howell; James Chang; Clare Heyworth; BI Lord; Nydia G Testa; TM Dexter; Geoffrey P Margison
Macrophage inflammatory protein 1alpha attenuates the toxic effects of temozolomide in human bone marrow granulocyte-macrophage colony-forming cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):966-70.
1999: Jan Dürig; Nydia G Testa; BI Lord; Christoph Kasper; James Chang; N Telford; TM Dexter; Clare Heyworth
Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1alpha.
Leukemia 1999;13(12):2012-22.
1999: Marina Scheller; John Foerster; Clare Heyworth; JF Waring; Jürgen Löhler; GL Gilmore; Richard K Shadduck; TM Dexter; Ivan Horak
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
Blood 1999;94(11):3764-71.
1999: Caroline A Evans; Andrew Pierce; S A Winter; Elaine Spooncer; Clare Heyworth; Anthony D Whetton
Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.
Blood 1999;94(5):1504-14.
1999: Clare Heyworth; Karin Gale; M Dexter; Gillian May; Tariq Enver
A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal.
Genes & development 1999;13(14):1847-60.
1999: B A Johnson; V A John; Reinhard Henschler; Ian N Hampson; Clare Heyworth; CK Babichuk; R Chris Bleackley; TM Dexter; Michael Cross
Upstream elements bestow T-cell and haemopoietic progenitor-specific activity on the granzyme B promoter.
Gene 1999;234(1):101-7.
1999: Lloyd Czaplewski; J McKeating; C J Craven; Lee D Higgins; V Appay; A Brown; Tim Dudgeon; L A Howard; T Meyers; J Owen; Shilpa Palan; P Tan; G Wilson; N R Woods; Clare Heyworth; BI Lord; D Brotherton; R Christison; S Craig; S Cribbes; R M Edwards; S J Evans; R Gilbert; P Morgan; E Randle; Nichola Schofield; Paul Varley; Julie Fisher; Jonathan P Waltho; MG Hunter
Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
The Journal of biological chemistry 1999;274(23):16077-84.
1999: Jan Dürig; Nydia G Testa; Clare Heyworth
Distinct biological effects of macrophage inflammatory protein-1alpha and stroma-derived factor-1alpha on CD34+ hemopoietic cells.
Stem cells (Dayton, Ohio) 1999;17(2):62-71.
1998: Jan Dürig; Erika A de Wynter; Christoph Kasper; Michael Cross; James Chang; Nydia G Testa; Clare Heyworth
Expression of macrophage inflammatory protein-1 receptors in human CD34(+) hematopoietic cells and their modulation by tumor necrosis factor-alpha and interferon-gamma.
Blood 1998;92(9):3073-81.
1998: Tariq Enver; Clare Heyworth; TM Dexter
Do stem cells play dice?
Blood 1998;92(2):348-51; discussion 352.
1998: Andrew Pierce; Clare Heyworth; SE Nicholls; Elaine Spooncer; TM Dexter; J M Lord; P Jane Owen-Lynch; G Wark; Anthony D Whetton
An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.
The Journal of cell biology 1998;140(6):1511-8.
1998: G Wark; Clare Heyworth; Elaine Spooncer; Lloyd Czaplewski; JM Francis; TM Dexter; Anthony D Whetton
Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha.
Oncogene 1998;16(10):1319-24.
1998: Andrew Pierce; Anthony D Whetton; P Jane Owen-Lynch; J Tavernier; Elaine Spooncer; TM Dexter; Clare Heyworth
Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.
Journal of cell science 1998;111 ( Pt 6)():815-23.
1998: Erika A de Wynter; J Durig; Michael Cross; Clare Heyworth; Nydia G Testa
Differential response of CD34+ cells isolated from cord blood and bone marrow to MIP-1 alpha and the expression of MIP-1 alpha receptors on these immature cells.
Stem cells (Dayton, Ohio) 1998;16(5):349-56.
1998: M A Pearson; A M O'Farrell; TM Dexter; Anthony D Whetton; P Jane Owen-Lynch; Clare Heyworth
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
Growth factors (Chur, Switzerland) 1998;15(4):293-306.
1997: M Hu; D Krause; M Greaves; Saul J Sharkis; M Dexter; Clare Heyworth; Tariq Enver
Multilineage gene expression precedes commitment in the hemopoietic system.
Genes & development 1997;11(6):774-85.
1997: Michael Cross; Clare Heyworth; TM Dexter
How do stem cells decide what to do?
Ciba Foundation symposium 1997;204():3-14; discussion 14-8.
1997: Ian N Hampson; Lynne Hampson; Michael J Pinkoski; Michael Cross; Clare Heyworth; R Chris Bleackley; E Atkinson; TM Dexter
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.
Blood 1997;89(1):108-18.
1996: Reinhard Henschler; H R Glatt; Clare Heyworth
Hydroquinone stimulates granulocyte-macrophage progenitor cells in vitro and in vivo.
Environmental health perspectives 1996;104 Suppl 6():1271-4.
1995: Clare Heyworth; M Alauldin; Michael Cross; Leslie J Fairbairn; TM Dexter; Anthony D Whetton
Erythroid development of the FDCP-Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3.
British journal of haematology 1995;91(1):15-22.
1995: S E Nicholls; Clare Heyworth; T M Dexter; J M Lord; G D Johnson; Anthony D Whetton
IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte-macrophage colony-forming cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):845-53.
1995: A M Murrell; EO Bockamp; Berthold Göttgens; Y S Chan; Michael Cross; Clare Heyworth; Anthony R Green
Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation.
Oncogene 1995;11(1):131-9.
1995: Clare Heyworth; M A Pearson; TM Dexter; G Wark; P Jane Owen-Lynch; Anthony D Whetton
Macrophage inflammatory protein-1 alpha mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 triphosphate generation.
Growth factors (Chur, Switzerland) 1995;12(3):165-72.
1994: Michael Cross; Clare Heyworth; A M Murrell; EO Bockamp; TM Dexter; Anthony R Green
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.
Oncogene 1994;9(10):3013-6.
1994: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Combinations of colony-stimulating factors promote enhanced proliferative potential in enriched granulocyte-macrophage colony-forming cells.
Experimental hematology 1994;22(11):1089-94.
1994: Anthony D Whetton; Clare Heyworth; SE Nicholls; C A Evans; J M Lord; TM Dexter; P Jane Owen-Lynch
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.
The Journal of cell biology 1994;125(3):651-9.
1994: TM Dexter; Clare Heyworth
Growth factors and the molecular control of haematopoiesis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13 Suppl 2():S3-8.
1993: BI Lord; Clare Heyworth; Lorna B Woolford
Macrophage inflammatory protein: its characteristics, biological properties and role in the regulation of haemopoiesis.
International journal of hematology 1993;57(3):197-206.
1993: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells.
Blood 1993;81(4):894-900.
1992: Ian N Hampson; Michael Cross; Clare Heyworth; Leslie J Fairbairn; Elaine Spooncer; G J Cowling; TM Dexter
Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines.
Blood 1992;80(12):3097-105.
1992: Clare Heyworth; Anthony D Whetton; S Nicholls; Krisztina Maria Zsebo; TM Dexter
Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors.
Blood 1992;80(9):2230-6.
1991: O Kan; Clare Heyworth; TM Dexter; P J Maudsley; N Cook; S J Vallance; Anthony D Whetton
Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells.
Blood 1991;78(10):2588-94.
1991: J Hampson; S Redmond; BI Lord; P Slocombe; A M O'Farrell; Clare Heyworth; TM Dexter
Selective inhibition of primitive hemopoietic colony-forming cells by an extract from normal marrow: comparison with transforming growth factor-beta.
Experimental hematology 1991;19(4):245-9.
1991: Clare Heyworth; J Hampson; TM Dexter; F Walker; A W Burgess; O Kan; N Cook; S J Vallance; Anthony D Whetton
Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocyte macrophage colony-stimulating factor: altered biological responses to GM-CSF during development.
Growth factors (Chur, Switzerland) 1991;5(2):87-98.
1991: I L Ponting; Clare Heyworth; F Cormier; TM Dexter
Serum-free culture of enriched murine haemopoietic stem cells. II: Effects of growth factors and haemin on development.
Growth factors (Chur, Switzerland) 1991;4(3):165-73.
1991: F Cormier; I L Ponting; Clare Heyworth; TM Dexter
Serum-free culture of enriched murine haemopoietic stem cells. I: Effect of haemopoietic growth factors on proliferation.
Growth factors (Chur, Switzerland) 1991;4(3):157-64.
1990: TM Dexter; Clare Heyworth; Elaine Spooncer; I L Ponting
The role of growth factors in self-renewal and differentiation of haemopoietic stem cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):85-98.
1990: TM Dexter; L H Coutinho; E Spooncer; Clare Heyworth; C P Daniel; R Schiro; J Chang; Terence Allen
Stromal cells in haemopoiesis.
Ciba Foundation symposium 1990;148():76-86; discussion 86-95.
1990: Clare Heyworth; S J Vallance; Anthony D Whetton; TM Dexter
The biochemistry and biology of the myeloid haemopoietic cell growth factors.
Journal of cell science. Supplement 1990;13():57-74.
1990: Clare Heyworth; TM Dexter; O Kan; Anthony D Whetton
The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells.
Growth factors (Chur, Switzerland) 1990;2(2-3):197-211.
1988: Anthony D Whetton; S J Vallance; Peter N Monk; E J Cragoe; TM Dexter; Clare Heyworth
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.
The Biochemical journal 1988;256(2):585-92.
1988: Clare Heyworth; I L Ponting; TM Dexter
The response of haemopoietic cells to growth factors: developmental implications of synergistic interactions.
Journal of cell science 1988;91 ( Pt 2)():239-47.
1988: Clare Heyworth; TM Dexter
The development of hemopoietic cells in response to stromal cells or growth factors is modified by agents that influence ADP-ribosylation.
Leukemia 1988;2(1):6-11.
1988: TM Dexter; I L Ponting; R A Roberts; Elaine Spooncer; Clare Heyworth; J T Gallagher
Growth and differentiation of hematopoietic stem cells.
Society of General Physiologists series 1988;43():25-38.