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Kewal Asosingh

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Kewal Asosingh; Georgiana Cheng; Xiaoxia Li; Benjamin M Savasky; Weiling Xu; Mark A Aronica; Serpil C Erzurum
Nascent endothelium initiates Th2 polarization of asthma.
Anja Schirbel; Gail West; Kewal Asosingh; Sean Kessler; Christine McDonald; Nancy Rebert; F Rieder; Claudio Fiocchi
Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.
Erika L Lundgrin; Donald R Neumann; Margaret M Park; Jacqueline Sharp; W H Wilson Tang; James D Thomas; Rubin M Tuder; Kewal Asosingh; Suzy A A Comhair; Laura Davis; Frank P DiFilippo; Iva Dostanic; Brian B Graham; Serpil C Erzurum
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.

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2013: Kewal Asosingh; Georgiana Cheng; Xiaoxia Li; Benjamin M Savasky; Weiling Xu; Mark A Aronica; Serpil C Erzurum
Nascent endothelium initiates Th2 polarization of asthma.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3458-65.
2013: Anja Schirbel; Gail West; Kewal Asosingh; Sean Kessler; Christine McDonald; Nancy Rebert; F Rieder; Claudio Fiocchi
Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.
Gastroenterology 2013;144(3):613-623.e9.
2013: Erika L Lundgrin; Donald R Neumann; Margaret M Park; Jacqueline Sharp; W H Wilson Tang; James D Thomas; Rubin M Tuder; Kewal Asosingh; Suzy A A Comhair; Laura Davis; Frank P DiFilippo; Iva Dostanic; Brian B Graham; Serpil C Erzurum
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.
Annals of the American Thoracic Society 2013;10(1):1-9.
2012: Kewal Asosingh; Micheala Aldred; Samar Farha; Deepa George; Brian Graham; Stanley L Hazen; Alan E Lichtin; James Loyd; Rubin M Tuder; Serpil C Erzurum
Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension.
Blood 2012;120(6):1218-27.
2012: Frank P DiFilippo; Kewal Asosingh; Sagar Patel; Serpil C Erzurum
Small-animal imaging using clinical positron emission tomography/computed tomography and super-resolution.
Molecular imaging 2012;11(3):210-9.
2012: Suzy A A Comhair; Micheala A Aldred; Kewal Asosingh; Lori Mavrakis; Weiling Xu; Serpil C Erzurum
Human primary lung endothelial cells in culture.
American journal of respiratory cell and molecular biology 2012;46(6):723-30.
2012: Samar Farha; Carol Farver; Fred Hsieh; James E Loyd; Margaret Park; Jacqueline Sharp; W H Wilson Tang; Jim Thomas; Kewal Asosingh; Suzy A A Comhair; Serpil C Erzurum
Mast cell number, phenotype, and function in human pulmonary arterial hypertension.
Pulmonary circulation 2012;2(2):220-8.
2012: Ilknur Basyigit; Serpil Erzurum; Gulfer Okumus; Kewal Asosingh; Despina Papakosta
Pulmonary hypertension.
Pulmonary medicine 2012;2012():893157.
2011: Heng T Duong; Serpil C Erzurum; Kewal Asosingh
Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation.
Angiogenesis 2011;14(4):411-22.
2011: Heng T Duong; Serpil C Erzurum; Lori Mavrakis; Benjamin M Savasky; Micheala A Aldred; Suzy A A Comhair; Kewal Asosingh
Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension.
Pulmonary circulation 2011;1(4):475-86.
2011: Samar Farha; Kewal Asosingh; Weiling Xu; Jacqueline Sharp; Deepa George; Suzy Comhair; Margaret Park; W H Wilson Tang; James E Loyd; Karl Theil; Raymond Tubbs; Eric Hsi; Alan Lichtin; Serpil C Erzurum
Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.
Blood 2011;117(13):3485-93.
2010: Micheala A Aldred; Suzy A Comhair; Marileila Varella-Garcia; Kewal Asosingh; Weiling Xu; George P Noon; Patricia A Thistlethwaite; Rubin M Tuder; Serpil C Erzurum; Mark W Geraci; Christopher Coldren
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2010;182(9):1153-60.
2010: Kevin Tan; Emma Lessieur; Alecia Cutler; Patrice Nerone; Amit Vasanji; Kewal Asosingh; Serpil Erzurum; Bela Anand-Apte
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.
Experimental eye research 2010;91(2):229-37.
2010: Flavia L Barbosa; Shyam S Chaurasia; Alicia Cutler; Kewal Asosingh; Harmet Kaur; Fabricio W de Medeiros; Vandana Agrawal; Steven E Wilson
Corneal myofibroblast generation from bone marrow-derived cells.
Experimental eye research 2010;91(1):92-6.
2010: Kewal Asosingh; Jodi D Hanson; Georgiana Cheng; Mark A Aronica; Serpil C Erzurum
Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia.
The Journal of allergy and clinical immunology 2010;125(4):918-25.
2010: Quteba Ebrahem; Shyam S Chaurasia; Amit Vasanji; Jian Hua Qi; Phillip A Klenotic; Alecia Cutler; Kewal Asosingh; Serpil C Erzurum; Bela Anand-Apte
Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.
The American journal of pathology 2010;176(1):496-503.
2009: Samar Farha; Kewal Asosingh; Daniel Laskowski; Jeffrey P Hammel; Raed A Dweik; Herbert P Wiedemann; Serpil C Erzurum
Effects of the menstrual cycle on lung function variables in women with asthma.
American journal of respiratory and critical care medicine 2009;180(4):304-10.
2009: Kewal Asosingh; Serpil C Erzurum
Angioplasticity in asthma.
Biochemical Society transactions 2009;37(Pt 4):805-10.
2009: Kewal Asosingh; Serpil C Erzurum; Mervin C Yoder; Rubin M Tuder
Letter by asosingh et Al regarding article, "circulating endothelial progenitor cells in patients with eisenmenger syndrome and idiopathic pulmonary arterial hypertension".
Circulation 2009;119(9):e230; author reply e231.
2008: Elke De Bruyne; Tomas Bos; Kewal Asosingh; Isabelle Vande Broek; Eline Menu; Els Van Valckenborgh; Peter Atadja; Valérie Coiteux; Xavier Leleu; Kris Thielemans; Ben Van Camp; Karin Vanderkerken; Ivan Van Riet
Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(10):2918-26.
2008: Kewal Asosingh; Micheala A Aldred; Amit Vasanji; Judith A Drazba; Jacqueline Sharp; Carol Farver; Suzy A A Comhair; Weiling Xu; Lauren Licina; Lan Huang; Bela Anand-Apte; Mervin C Yoder; Rubin M Tuder; Serpil C Erzurum
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension.
The American journal of pathology 2008;172(3):615-27.
2007: Samar Farha; Kewal Asosingh; Daniel Laskowski; Lauren Licina; Haruki Sekiguchi; Haruki Sekigushi; Douglas Losordo; raed dweik; Herbert P Wiedemann; Serpil C Erzurum
Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(5):1789-95.
2007: Fares A Masri; Weiling Xu; Suzy A A Comhair; Kewal Asosingh; Michelle Koo; Amit Vasanji; Judith A Drazba; Bela Anand-Apte; Serpil C Erzurum
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology 2007;293(3):L548-54.
2007: Kewal Asosingh; Shadi Swaidani; Mark A Aronica; Serpil C Erzurum
Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6482-94.
2006: Eline Menu; Kewal Asosingh; Stefano Indraccolo; Hendrik De Raeve; Ivan Van Riet; Els Van Valckenborgh; Isabelle Vande Broek; Isabelle Van de Broek; Nobutaka Fujii; Hirokazu Tamamura; Ben Van Camp; Karin Vanderkerken
The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model.
Haematologica 2006;91(5):605-12.
2006: Eline Menu; Helena Jernberg-Wiklund; Thomas Stromberg; Hendrik De Raeve; Leonard Girnita; Olle Larsson; Magnus Axelson; Kewal Asosingh; Kenneth Nilsson; Ben Van Camp; Karin Vanderkerken
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Blood 2006;107(2):655-60.
2005: Kewal Asosingh; Hendrik De Raeve; Mark de Ridder; Guy Storme; Angelo Willems; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
Haematologica 2005;90(6):810-7.
2005: Karin Vanderkerken; Kewal Asosingh; Angelo Willems; Hendrik De Raeve; Pedro Couck; Frans K Gorus; Peter I Croucher; Ben Van Camp
The 5T2MM murine model of multiple myeloma: maintenance and analysis.
Methods in molecular medicine 2005;113():191-205.
2004: Maarten Timmers; Katrien Vekemans; David Vermijlen; Kewal Asosingh; Peter Kuppen; Luc Bouwens; Eddie Wisse; Filip Braet
Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis.
International journal of cancer. Journal international du cancer 2004;112(5):793-802.
2004: Hendrik De Raeve; Kewal Asosingh; Eddie Wisse; Ben Van Camp; Eric Van Marck; Karin Vanderkerken
Part of the multiple myeloma-associated microvessels is functionally connected to the systemic circulation: a study in the murine 5T33MM model.
Virchows Archiv : an international journal of pathology 2004;445(4):389-95.
2004: Els Van Valckenborgh; Peter I Croucher; Hendrik De Raeve; Chris Carron; Evy De Leenheer; Silvia Blacher; Laetitia Devy; Agnès Noël; Elke De Bruyne; Kewal Asosingh; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.
The American journal of pathology 2004;165(3):869-78.
2004: Eline Menu; Kewal Asosingh; Ivan Van Riet; Peter I Croucher; Ben Van Camp; Karin Vanderkerken
Myeloma cells (5TMM) and their interactions with the marrow microenvironment.
Blood cells, molecules & diseases 2004;33(2):111-9.
2004: Isabelle Vande Broek; Kewal Asosingh; V Allegaert; X Leleu; Thierry Facon; Karin Vanderkerken; Ben Van Camp; Ivan Van Riet
Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor.
Leukemia 2004;18(5):976-82.
2004: Kewal Asosingh; Hendrik De Raeve; Eline Menu; Ivan Van Riet; Eric Van Marck; Ben Van Camp; Karin Vanderkerken
Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity.
Blood 2004;103(8):3131-7.
2004: Eline Menu; Ron Kooijman; Els Van Valckenborgh; Kewal Asosingh; Marleen Bakkus; Ben Van Camp; Karin Vanderkerken
Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.
British journal of cancer 2004;90(5):1076-83.
2004: Marc De Waele; W Renmans; Kewal Asosingh; K Vander Gucht; Ivan Van Riet
Growth factor receptor profile of CD34 cells in normal bone marrow, cord blood and mobilized peripheral blood.
European journal of haematology 2004;72(3):193-202.
2003: Karin Vanderkerken; Kewal Asosingh; Peter I Croucher; Ben Van Camp
Multiple myeloma biology: lessons from the 5TMM models.
Immunological reviews 2003;194():196-206.
2003: Kewal Asosingh; Angelo Willems; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Delayed in vivo disease progression is associated with high proportions of CD45+ myeloma cells in the 5T2MM murine model.
Cancer research 2003;63(12):3019-20.
2003: Kewal Asosingh; Hendrik De Raeve; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Multiple myeloma tumor progression in the 5T2MM murine model is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis.
Blood 2003;101(8):3136-41.
2003: Isabelle Vande Broek; Kewal Asosingh; Karin Vanderkerken; N Straetmans; Ben Van Camp; Ivan Van Riet
Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3.
British journal of cancer 2003;88(6):855-62.
2003: Karin Vanderkerken; Evy De Leenheer; Claire M Shipman; Kewal Asosingh; Angelo Willems; Ben Van Camp; Peter I Croucher
Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma.
Cancer research 2003;63(2):287-9.
2003: Kewal Asosingh; Virginie Vankerkhove; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Selective in vivo growth of lymphocyte function- associated antigen-1-positive murine myeloma cells. Involvement of function-associated antigen-1-mediated homotypic cell-cell adhesion.
Experimental hematology 2003;31(1):48-55.
2002: Els Van Valckenborgh; Marleen Bakkus; Carine Munaut; Agnès Noël; Yves St Pierre; Kewal Asosingh; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells.
International journal of cancer. Journal international du cancer 2002;101(6):512-8.
2002: Kewal Asosingh; Eline Menu; Els Van Valckenborgh; Isabelle Vande Broek; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma.
Clinical & experimental metastasis 2002;19(7):583-91.
2002: Isabelle Vande Broek; Kewal Asosingh; Karin Vanderkerken; Ivan Van Riet; Ben Van Camp
Multiple myeloma, a model for fundamental and clinical research.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2002;64(4):261-84; discussion 284-6.
2002: Karin Vanderkerken; Isabelle Vande Broek; Decio L Eizirik; Els Van Valckenborgh; Kewal Asosingh; Ivan Van Riet; Ben Van Camp
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.
Clinical & experimental metastasis 2002;19(1):87-90.
2001: Peter I Croucher; Claire M Shipman; Jennifer M Lippitt; M Perry; Kewal Asosingh; A Hijzen; Alex C Brabbs; Edwin J.R. van Beek; Ingunn Holen; Timothy M Skerry; C R Dunstan; G R Russell; Ben Van Camp; Karin Vanderkerken
Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma.
Blood 2001;98(13):3534-40.
2001: Isabelle Vande Broek; Karin Vanderkerken; Catherine De Greef; Kewal Asosingh; N Straetmans; Ben Van Camp; Ivan Van Riet
Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor.
British journal of cancer 2001;85(9):1387-95.
2001: Marleen Bakkus; Kewal Asosingh; Karin Vanderkerken; Kris Thielemans; A Hagemeijer; Hendrik De Raeve; Ben Van Camp
Myeloma isotype-switch variants in the murine 5T myeloma model: evidence that myeloma IgM and IgA expressing subclones can originate from the IgG expressing tumour.
Leukemia 2001;15(7):1127-32.
2001: Dianzhong Luo; Karin Vanderkerken; M C Chen; David Vermijlen; Kewal Asosingh; E Willems; V Triantis; D L Eizirik; Peter Kuppen; Eddie Wisse
Rat hepatic natural killer cells (pit cells) express mRNA and protein similar to in vitro interleukin-2 activated spleen natural killer cells.
Cellular immunology 2001;210(1):41-8.
2001: Kewal Asosingh; Ursula Günthert; Hendrik De Raeve; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
A unique pathway in the homing of murine multiple myeloma cells: CD44v10 mediates binding to bone marrow endothelium.
Cancer research 2001;61(7):2862-5.
2001: Kewal Asosingh; Hendrik De Raeve; Peter I Croucher; E Goes; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
In vivo homing and differentiation characteristics of mature (CD45-) and immature (CD45+) 5T multiple myeloma cells.
Experimental hematology 2001;29(1):77-84.
2000: Claire M Shipman; Karin Vanderkerken; Michael J Rogers; Jennifer M Lippitt; Kewal Asosingh; David Hughes; Ben Van Camp; R Graham G Russell; Peter I Croucher
The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.
British journal of haematology 2000;111(1):283-6.
2000: Kewal Asosingh; Ursula Günthert; Marleen Bakkus; Hendrik De Raeve; E Goes; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.
Cancer research 2000;60(11):3096-104.
2000: Karin Vanderkerken; Catherine De Greef; Kewal Asosingh; B Arteta; M De Veerman; Isabelle Vande Broek; Ivan Van Riet; M Kobayashi; B Smedsrod; Ben Van Camp
Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse.
British journal of cancer 2000;82(4):953-9.
2000: Kewal Asosingh; J Radl; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
The 5TMM series: a useful in vivo mouse model of human multiple myeloma.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(5):351-6.
2000: Karin Vanderkerken; Ben Van Camp; Catherine De Greef; Isabelle Vande Broek; Kewal Asosingh; Ivan Van Riet
Homing of the myeloma cell clone.
Acta oncologica (Stockholm, Sweden) 2000;39(7):771-6.
1999: Karin Vanderkerken; Kewal Asosingh; Filip Braet; Ivan Van Riet; Ben Van Camp
Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells.
Blood 1999;93(1):235-41.
1998: Kewal Asosingh; W Renmans; K Van der Gucht; W Foulon; Rik Schots; Ivan Van Riet; Marc De Waele
Circulating CD34+ cells in cord blood and mobilized blood have a different profile of adhesion molecules than bone marrow CD34+ cells.
European journal of haematology 1998;60(3):153-60.