FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert Hider

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

Occupations

Drug Design

Genes & Molecular Sequences

Molecular Structure

Procedures

Disorders

Iron Overload

Co-author Network

Publications

TOP 3
Robert C Hider; Xiaole Kong
Iron speciation in the cytosol: an overview.
Yongmin Ma; Yuanyuan Xie; Robert C Hider
A novel fluorescence method for determination of pFe3+.
Yu-Lin Chen; Xiao-Le Kong; Yong-Min Ma; Dave J Barlow; Robert C Hider
Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III).

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert Hider (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Robert C Hider; Xiaole Kong
Iron speciation in the cytosol: an overview.
Dalton transactions (Cambridge, England : 2003) 2013;42(9):3220-9.
2013: Yongmin Ma; Yuanyuan Xie; Robert C Hider
A novel fluorescence method for determination of pFe3+.
The Analyst 2013;138(1):96-9.
2012: Yu-Lin Chen; Xiao-Le Kong; Yong-Min Ma; Dave J Barlow; Robert C Hider
Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III).
Dalton transactions (Cambridge, England : 2003) 2012;41(35):10784-91.
2012: Yu-Lin Chen; Xiao-Le Kong; Yong-Min Ma; Dave J Barlow; Robert C Hider
Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6549-57.
2012: Tao Zhou; Xiaole Kong; Yongmin Ma; Robert C Hider
Design of iron chelators with therapeutic application.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6371-89.
2012: Miranda C E Lomer; William B Cook; Robert C Hider; Carol Hutchinson; Hamid Jan B Jan-Mohamed; Ding Yong Liu; Jonathan J Powell
Iron requirements based upon iron absorption tests are poorly predicted by haematological indices in patients with inactive inflammatory bowel disease.
The British journal of nutrition 2012;107(12):1806-11.
2012: Yongmin Ma; Sourav Roy; Yulin Chen; Xiaole Kong; Dingyong Liu; Robert C Hider
Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake.
Journal of medicinal chemistry 2012;55(5):2185-95.
2011: Robert C Hider; Xiao L Kong
Glutathione: a key component of the cytoplasmic labile iron pool.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2011;24(6):1179-87.
2011: Bo Xu; Rong-Hua Yang; Tao Zhou; Yu-Lin Chen; Xiao-Le Kong; Mu-Song Liu; Di-Hong Qiu; Robert C Hider
Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents.
Bioorganic & medicinal chemistry letters 2011;21(21):6376-80.
2011: Tao Zhou; Günther Winkelmann; Zhi-Yuan Dai; Robert C Hider
Design of clinically useful macromolecular iron chelators.
The Journal of pharmacy and pharmacology 2011;63(7):893-903.
2011: Kirsten Staff; Marc B Brown; Robert P Chilcott; Robert C Hider; Stuart A Jones; Xiao L Kong
Ga(III) complexes--the effect of metal coordination on potential systemic absorption after topical exposure.
Toxicology letters 2011;202(3):155-60.
2011: Alessandra Gaeta; Francisco Molina-Holgado; Xiao L Kong; Sarah Salvage; Sarah Fakih; Paul T Francis; Robert J Williams; Robert C Hider
Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease.
Bioorganic & medicinal chemistry 2011;19(3):1285-97.
2010: Iain C Macdougall; Jolanta Malyszko; Robert C Hider; Sukhvinder S Bansal
Current status of the measurement of blood hepcidin levels in chronic kidney disease.
Clinical journal of the American Society of Nephrology : CJASN 2010;5(9):1681-9.
2010: K Staff; Marc B Brown; Robert C Hider; X L Kong; P Friden; Stuart A Jones
Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography.
Biomedical chromatography : BMC 2010;24(9):1015-22.
2010: Tao Zhou; Robert C Hider; Peter Jenner; Bruce Campbell; Christopher J Hobbs; Sarah Rose; Mark Jairaj; Kayhan A Tayarani-Binazir; Alexander Syme
Design, synthesis and biological evaluation of L-dopa amide derivatives as potential prodrugs for the treatment of Parkinson's disease.
European journal of medicinal chemistry 2010;45(9):4035-42.
2010: Sourav Roy; Jane E Preston; Robert C Hider; Yong Min Ma
Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier.
Journal of medicinal chemistry 2010;53(15):5886-9.
2010: Robert C Hider; A M N Silva; M Podinovskaia; Yongmin Ma
Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron.
Annals of the New York Academy of Sciences 2010;1202():94-9.
2010: Patricia Evans; Reem Kayyali; Robert C Hider; John Eccleston; John B Porter
Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.
Translational research : the journal of laboratory and clinical medicine 2010;156(2):55-67.
2010: Yun Lan; Bérangère Langlet-Bertin; Vincenzo Abbate; Louic S Vermeer; Xiaole Kong; Kelly E Sullivan; Christian Leborgne; Daniel Scherman; Robert C Hider; Alex F Drake; Sukhvinder S Bansal; Antoine Kichler; A James Mason
Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors.
Chembiochem : a European journal of chemical biology 2010;11(9):1266-72.
2010: Sukhvinder S Bansal; Vincenzo Abbate; Adrian Bomford; John M Halket; Iain C Macdougall; Swee Lay Thein; Robert C Hider
Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer.
Rapid communications in mass spectrometry : RCM 2010;24(9):1251-9.
2010: Robert C Hider; Xiaole Kong
Chemistry and biology of siderophores.
Natural product reports 2010;27(5):637-57.
2010: Robert C Hider
Charge states of deferasirox-ferric iron complexes.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2010;55(3):614-5.
2009: Yong Min Ma; Robert C Hider
The selective quantification of iron by hexadentate fluorescent probes.
Bioorganic & medicinal chemistry 2009;17(23):8093-101.
2009: Andre M N Silva; XiaoLe Kong; Mark C Parkin; Richard Cammack; Robert C Hider
Iron(III) citrate speciation in aqueous solution.
Dalton transactions (Cambridge, England : 2003) 2009;(40):8616-25.
2009: Andre M N Silva; Robert C Hider
Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation.
Biochimica et biophysica acta 2009;1794(10):1449-58.
2009: Andre M N Silva; XiaoLe Kong; Robert C Hider
Determination of the pKa value of the hydroxyl group in the alpha-hydroxycarboxylates citrate, malate and lactate by 13C NMR: implications for metal coordination in biological systems.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2009;22(5):771-8.
2009: Sukhvinder S Bansal; John M Halket; Jane Fusova; Adrian Bomford; Robert J Simpson; Nisha Vasavda; Swee Lay Thein; Robert C Hider
Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(11):1531-42.
2009: Abas H Laftah; Gladys O Latunde-Dada; Sarah Fakih; Robert C Hider; Robert J Simpson; Andrew T McKie
Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1).
The British journal of nutrition 2009;101(8):1150-6.
2009: Sukhvinder S Bansal; John M Halket; Adrian Bomford; Robert J Simpson; Nisha Vasavda; Swee Lay Thein; Robert C Hider
Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry.
Analytical biochemistry 2009;384(2):245-53.
2008: Robert C Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy
Iron chelation as a potential therapy for neurodegenerative disease.
Biochemical Society transactions 2008;36(Pt 6):1304-8.
2008: Sarah Fakih; Maria Podinovskaia; Xiaole Kong; Helen L Collins; Ulrich E Schaible; Robert C Hider
Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools.
Journal of medicinal chemistry 2008;51(15):4539-52.
2008: Francisco Molina-Holgado; Alessandra Gaeta; Paul T Francis; Robert J Williams; Robert C Hider
Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells.
Journal of neurochemistry 2008;105(6):2466-76.
2008: Tao Zhou; Xiao Le Kong; Zu Dong Liu; Ding Yong Liu; Robert C Hider
Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers.
Biomacromolecules 2008;9(5):1372-80.
2008: Xiaole Kong; Hendrik Neubert; Tao Zhou; Zu Dong Liu; Robert C Hider
MALDI mass spectrometric determination of dendritic iron chelation stoichiometries and conditional affinity constants.
Journal of mass spectrometry : JMS 2008;43(5):617-22.
2008: L Faas; Radhakrishnan Venkatasamy; Robert C Hider; Antony R Young; Amala Soumyanath
In vivo evaluation of piperine and synthetic analogues as potential treatments for vitiligo using a sparsely pigmented mouse model.
The British journal of dermatology 2008;158(5):941-50.
2008: Lotfollah S Dehkordi; Zu D Liu; Robert C Hider
Basic 3-hydroxypyridin-4-ones: potential antimalarial agents.
European journal of medicinal chemistry 2008;43(5):1035-47.
2008: Carol Hutchinson; Rana E Conway; Adrian Bomford; Robert C Hider; Jonathan J Powell; Catherine A Geissler
Post-prandial iron absorption in humans: comparison between HFE genotypes and iron deficiency anaemia.
Clinical nutrition (Edinburgh, Scotland) 2008;27(2):258-63.
2008: Lakshmi D Devanur; Hendrik Neubert; Robert C Hider
The fenton activity of iron(III) in the presence of deferiprone.
Journal of pharmaceutical sciences 2008;97(4):1454-67.
2008: Lakshmi D Devanur; Robert W Evans; Patricia J Evans; Robert C Hider
Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy.
The Biochemical journal 2008;409(2):439-47.
2008: Robert W Evans; R Rafique; Adel Zarea; Chiara Rapisarda; Richard Cammack; Patricia J Evans; John B Porter; Robert C Hider
Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(1):57-74.
2007: Xiaole Kong; Tao Zhou; zudong liu; Robert C Hider
pH indicator titration: a novel fast pKa determination method.
Journal of pharmaceutical sciences 2007;96(10):2777-83.
2007: Zhixiu Lin; Yonghong Liao; Radhakrishnan Venkatasamy; Robert C Hider; Amala Soumyanath
Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro.
The Journal of pharmacy and pharmacology 2007;59(4):529-36.
2007: Yongmin Ma; Zudong Liu; Robert C Hider; Frank Petrat
Determination of the labile iron pool of human lymphocytes using the fluorescent probe, CP655.
Analytical chemistry insights 2007;2():61-7.
2006: Amala Soumyanath; Radhakrishnan Venkatasamy; Meghna Joshi; Laura Faas; Bimpe Adejuyigbe; Alex F Drake; Robert C Hider; Antony R Young
UV irradiation affects melanocyte stimulatory activity and protein binding of piperine.
Photochemistry and photobiology 2006;82(6):1541-8.
2006: Tao Zhou; Hendrik Neubert; Ding Yong Liu; Zu D Liu; Yong Min Ma; Xiao Le Kong; Wei Luo; Sykes Mark; Robert C Hider
Iron binding dendrimers: a novel approach for the treatment of haemochromatosis.
Journal of medicinal chemistry 2006;49(14):4171-82.
2006: Yuhao Ren; Peter Houghton; Robert C Hider
Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease.
The Journal of pharmacy and pharmacology 2006;58(7):989-96.
2006: Xiaole Kong; Tao Zhou; Hendrik Neubert; zudong liu; Robert C Hider
3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand?
Journal of medicinal chemistry 2006;49(10):3028-31.
2006: Yongmin Ma; Herbert de Groot; zudong liu; Robert C Hider; Frank Petrat
Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes.
The Biochemical journal 2006;395(1):49-55.
2006: Karine Barral; Jan Balzarini; Johan Neyts; Erik De Clercq; Robert C Hider; Michel Camplo
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.
Journal of medicinal chemistry 2006;49(1):43-50.
2005: Tao Zhou; Zu D Liu; Hendrik Neubert; Xiao Le Kong; Yong Min Ma; Robert C Hider
High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: synthesis and characterization.
Bioorganic & medicinal chemistry letters 2005;15(22):5007-11.
2005: Ursula E C Berndt; Tao Zhou; Robert C Hider; Zu D Liu; Hendrik Neubert
Structural characterization of chelator-terminated dendrimers and their synthetic intermediates by mass spectrometry.
Journal of mass spectrometry : JMS 2005;40(9):1203-14.
2005: Yongmin Ma; Wei Luo; Michel Camplo; zudong liu; Robert C Hider
Novel iron-specific fluorescent probes.
Bioorganic & medicinal chemistry letters 2005;15(14):3450-2.
2005: Robert C Hider; Tao Zhou
The design of orally active iron chelators.
Annals of the New York Academy of Sciences 2005;1054():141-54.
2004: Yongmin Ma; Wei Luo; Peter J Quinn; zudong liu; Robert C Hider
Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.
Journal of medicinal chemistry 2004;47(25):6349-62.
2004: Radhakrishnan Venkatasamy; Laura Faas; Antony R Young; Amala Raman; Robert C Hider
Effects of piperine analogues on stimulation of melanocyte proliferation and melanocyte differentiation.
Bioorganic & medicinal chemistry 2004;12(8):1905-20.
2004: Wei Luo; Yong Min Ma; Peter J Quinn; Robert C Hider; Zu D Liu
Design, synthesis and properties of novel iron(III)-specific fluorescent probes.
The Journal of pharmacy and pharmacology 2004;56(4):529-36.
2004: Yuhao Ren; Peter J Houghton; Robert C Hider; Melanie-Jayne R Howes
Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza.
Planta medica 2004;70(3):201-4.
2004: Elizabeth A Lewis; Hicham H Khodr; Robert C Hider; John R Lindsay Smith; Paul H Walton
A manganese superoxide dismutase mimic based on cis,cis-1,3,5-triaminocyclohexane.
Dalton transactions (Cambridge, England : 2003) 2004;(2):187-8.
2003: Karine Barral; Robert C Hider; Jan Balzarini; Johan Neyts; Erik De Clercq; Michel Camplo
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.
Bioorganic & medicinal chemistry letters 2003;13(24):4371-4.
2003: Robert C Hider; Zu D Liu
Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overload.
Current medicinal chemistry 2003;10(12):1051-64.
2002: Hicham H Khodr; Robert C Hider; A-K Duhme-Klair
The iron-binding properties of aminochelin, the mono(catecholamide) siderophore of Azotobacter vinelandii.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(7-8):891-6.
2002: Robert C Hider
Design of therapeutic chelating agents.
Biochemical Society transactions 2002;30(4):751-4.
2002: Ding Yong Liu; Zu D Liu; S Piyamongkol; SL Lu; Robert C Hider
Characterization of two isomeric beta-d-glucosiduronic acids derived from 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rat liver homogenate incubates.
The Journal of pharmacy and pharmacology 2002;54(7):951-7.
2002: Ding Yong Liu; Zu D Liu; Robert C Hider
Oral iron chelators--development and application.
Best practice & research. Clinical haematology 2002;15(2):369-84.
2002: Majid Y Moridani; Gary S Tilbrook; Hicham H Khodr; Robert C Hider
Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxypyridin-4-ones, novel iron chelators.
The Journal of pharmacy and pharmacology 2002;54(3):349-64.
2002: Niki A Georgiou; Tjomme van der Bruggen; Maroeska Oudshoorn; Robert C Hider; Joannes Marx; B Sweder van Asbeck
Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis.
European journal of clinical investigation 2002;32 Suppl 1():91-6.
2002: Robert C Hider
Nature of nontransferrin-bound iron.
European journal of clinical investigation 2002;32 Suppl 1():50-4.
2002: Menno P Kooistra; S Kersting; I Gosriwatana; S Lu; J Nijhoff-Schutte; Robert C Hider; Joannes Marx
Nontransferrin-bound iron in the plasma of haemodialysis patients after intravenous iron saccharate infusion.
European journal of clinical investigation 2002;32 Suppl 1():36-41.
2002: T M Rooyakkers; Erik S G Stroes; Menno P Kooistra; Ernst E van Faassen; Robert C Hider; ton rabelink; Joannes Marx
Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo.
European journal of clinical investigation 2002;32 Suppl 1():9-16.
2002: Zu D Liu; Reem Kayyali; Robert C Hider; John B Porter; Anthony E Theobald
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators.
Journal of medicinal chemistry 2002;45(3):631-9.
2002: Zu D Liu; Ding Yong Liu; Robert C Hider
Iron chelator chemistry.
Advances in experimental medicine and biology 2002;509():141-66.
2002: Zu D Liu; Robert C Hider
Design of clinically useful iron(III)-selective chelators.
Medicinal research reviews 2002;22(1):26-64.
2001: Reem Kayyali; John B Porter; Zu D Liu; Nathan A Davies; Jonathan H A Nugent; Chris E Cooper; Robert C Hider
Structure-function investigation of the interaction of 1- and 2-substituted 3-hydroxypyridin-4-ones with 5-lipoxygenase and ribonucleotide reductase.
The Journal of biological chemistry 2001;276(52):48814-22.
2001: Zu D Liu; S Piyamongkol; Ding Yong Liu; Hicham H Khodr; SL Lu; Robert C Hider
Synthesis of 2-amido-3-hydroxypyridin-4(1H)-ones: novel iron chelators with enhanced pFe3+ values.
Bioorganic & medicinal chemistry 2001;9(3):563-73.
2001: Zu D Liu; M Lockwood; S Rose; Anthony E Theobald; Robert C Hider
Structure-activity investigation of the inhibition of 3-hydroxypyridin-4-ones on mammalian tyrosine hydroxylase.
Biochemical pharmacology 2001;61(3):285-90.
2001: Robert C Hider; Zu D Liu; Hicham H Khodr
Metal chelation of polyphenols.
Methods in enzymology 2001;335():190-203.
2000: Zu D Liu; S Piyamongkol; Robert C Hider
The design and properties of 3-hydroxypyridin-4-one iron chelators with high pFe(3+) values.
Transfusion science 2000;23(3):269-70.
2000: Robert C Hider; Zu D Liu; S Piyamongkol
The design and properties of 3-hydroxypyridin-4-one iron chelators with high pFe(3+) values.
Transfusion science 2000;23(3):201-9.
2000: N von Wirén; Hicham H Khodr; Robert C Hider
Hydroxylated phytosiderophore species possess an enhanced chelate stability and affinity for iron(III).
Plant physiology 2000;124(3):1149-58.
2000: SL Lu; I Gosriwatana; Ding Yong Liu; Zu D Liu; A I Mallet; Robert C Hider
Biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):873-9.
2000: Ding Yong Liu; Zu D Liu; SL Lu; Robert C Hider
Hydrolytic and metabolic characteristics of the esters of 1-(3'-hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41), potentially useful iron chelators.
Pharmacology & toxicology 2000;86(5):228-33.
2000: Zu D Liu; Ding Yong Liu; SL Lu; Robert C Hider
Design, synthesis, and biological evaluation of aromatic ester prodrugs of 1-(3'-hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) as orally active iron chelators.
Arzneimittel-Forschung 2000;50(5):461-70.
2000: Olivier Loréal; I Gosriwatana; Dominique Guyader; J Porter; P Brissot; Robert C Hider
Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method.
Journal of hepatology 2000;32(5):727-33.
2000: Zu D Liu; Hicham H Khodr; SL Lu; Robert C Hider
Design, synthesis and evaluation of N-basic substituted 3-hydroxypyridin-4-ones: orally active iron chelators with lysosomotrophic potential.
The Journal of pharmacy and pharmacology 2000;52(3):263-72.
2000: B de Valk; M A Addicks; I Gosriwatana; S Lu; Robert C Hider; Joannes Marx
Non-transferrin-bound iron is present in serum of hereditary haemochromatosis heterozygotes.
European journal of clinical investigation 2000;30(3):248-51.
2000: AN Dodoo; Sukhvinder S Bansal; David J Barlow; F Bennet; Robert C Hider; Alison B Lansley; M Jayne Lawrence; Christopher Marriott
Use of alveolar cell monolayers of varying electrical resistance to measure pulmonary peptide transport.
Journal of pharmaceutical sciences 2000;89(2):223-31.
2000: AN Dodoo; S Bansal; David J Barlow; F C Bennet; Robert C Hider; Alison B Lansley; M Jayne Lawrence; Christopher Marriott
Systematic investigations of the influence of molecular structure on the transport of peptides across cultured alveolar cell monolayers.
Pharmaceutical research 2000;17(1):7-14.
1999: Ding Yong Liu; Zu D Liu; SL Lu; Robert C Hider
Liquid extraction and ion-pair HPLC for determination of hydrophilic 3-hydroxypyridin-4-one iron chelators.
Journal of pharmaceutical and biomedical analysis 1999;21(4):759-65.
1999: Zu D Liu; Hicham H Khodr; Ding Yong Liu; SL Lu; Robert C Hider
Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones: novel iron chelators with enhanced pFe(3+) values.
Journal of medicinal chemistry 1999;42(23):4814-23.
1999: B L Ellis; C B Sampson; R D Abeysinghe; John B Porter; Robert C Hider
6-Alkoxymethyl-3-hydroxy-4H-pyranones: potential ligands for cell-labelling with indium.
European journal of nuclear medicine 1999;26(11):1400-6.
1999: I Gosriwatana; O Loreal; S Lu; P Brissot; J Porter; Robert C Hider
Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin.
Analytical biochemistry 1999;273(2):212-20.
1999: Ding Yong Liu; Zu D Liu; SL Lu; Robert C Hider
Gradient ion-pair high-performance liquid chromatographic method for analysis of 3-hydroxypyridin-4-one iron chelators.
Journal of chromatography. B, Biomedical sciences and applications 1999;730(1):135-9.
1999: M D Habgood; Zu D Liu; L S Dehkordi; Hicham H Khodr; J Abbott; Robert C Hider
Investigation into the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability.
Biochemical pharmacology 1999;57(11):1305-10.
1999: F A Bennett; David J Barlow; AN Dodoo; Robert C Hider; Alison B Lansley; M Jayne Lawrence; Christopher Marriott; Sukhvinder S Bansal
Synthesis and properties of (6,7-dimethoxy-4-coumaryl)alanine: a fluorescent peptide label.
Analytical biochemistry 1999;270(1):15-23.
1999: Robert C Hider; Doug Bittel; Glen K Andrews
Competition between iron(III)-selective chelators and zinc-finger domains for zinc(II).
Biochemical pharmacology 1999;57(9):1031-5.
1999: Zu D Liu; Ding Yong Liu; SL Lu; Robert C Hider
Synthesis, physicochemical properties and biological evaluation of aromatic ester prodrugs of 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102): orally active iron chelators with clinical potential.
The Journal of pharmacy and pharmacology 1999;51(5):555-64.
1999: Zu D Liu; SL Lu; Robert C Hider
In vivo iron mobilisation evaluation of hydroxypyridinones in 59Fe-ferritin-loaded rat model.
Biochemical pharmacology 1999;57(5):559-66.
1998: B L Rai; L S Dekhordi; Hicham H Khodr; Y Jin; zudong liu; Robert C Hider
Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
Journal of medicinal chemistry 1998;41(18):3347-59.
1998: Reem Kayyali; Ananth S Pannala; Hicham H Khodr; Robert C Hider
Comparative radical scavenging ability of bidentate iron (III) chelators.
Biochemical pharmacology 1998;55(8):1327-32.
1998: J E Brown; Hicham H Khodr; Robert C Hider; Catherine A Rice-Evans
Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties.
The Biochemical journal 1998;330 ( Pt 3)():1173-8.
1998: G S Tilbrook; Robert C Hider
Iron chelators for clinical use.
Metal ions in biological systems 1998;35():691-730.
1997: R Choudhury; R O Epemolu; B L Rai; Robert C Hider; S Singh
Metabolism and pharmacokinetics of 1-(2'-trimethylacetoxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP117) in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(3):332-9.
1996: B L Ellis; A K Duhme; Robert C Hider; M B Hossain; S Rizvi; Dick van der Helm
Synthesis, physicochemical properties, and biological evaluation of hydroxypyranones and hydroxypyridinones: novel bidentate ligands for cell-labeling.
Journal of medicinal chemistry 1996;39(19):3659-70.
1996: Chris E Cooper; G R Lynagh; K P Hoyes; Robert C Hider; Richard Cammack; John B Porter
The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase.
The Journal of biological chemistry 1996;271(34):20291-9.
1996: J B Porter; R D Abeysinghe; L Marshall; Robert C Hider; S Singh
Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy.
Blood 1996;88(2):705-13.
1996: R D Abeysinghe; P J Roberts; Chris E Cooper; K H MacLean; Robert C Hider; John B Porter
The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone iron chelators.
The Journal of biological chemistry 1996;271(14):7965-72.
1996: S Singh; R Choudhury; R O Epemolu; Robert C Hider
Metabolism and pharmacokinetics of 1-(2'-hydroxy-ethyl)- and 1-(3'-hydroxypropyl)-2-ethyl-3-hydroxypyridin-4-ones in the rat.
European journal of drug metabolism and pharmacokinetics 1996;21(1):33-41.
1996: Robert C Hider; R Choudhury; B L Rai; L S Dehkordi; S Singh
Design of orally active iron chelators.
Acta haematologica 1996;95(1):6-12.
1995: Robert C Hider
Potential protection from toxicity by oral iron chelators.
Toxicology letters 1995;82-83():961-7.
1995: S Singh; Khodr Hicham; M I Taylor; Robert C Hider
Therapeutic iron chelators and their potential side-effects.
Biochemical Society symposium 1995;61():127-37.
1994: R O Epemolu; R Ackerman; John B Porter; Robert C Hider; Lyaquat A Damani; S Singh
HPLC determination of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide conjugate [CP94-GLUC] in serum and urine of thalassaemic patients.
Journal of pharmaceutical and biomedical analysis 1994;12(7):923-30.
1994: John B Porter; S Singh; K P Hoyes; O Epemolu; R D Abeysinghe; Robert C Hider
Lessons from preclinical and clinical studies with 1,2-diethyl-3-hydroxypyridin-4-one, CP94 and related compounds.
Advances in experimental medicine and biology 1994;356():361-70.
1994: Robert C Hider; O Epemolu; S Singh; John B Porter
Iron chelator design.
Advances in experimental medicine and biology 1994;356():343-9.
1993: G Xiao; Dick van der Helm; F H Goerlitz; Robert C Hider; P S Dobbin
Structures of 3-hydroxy-1-(2-methoxyethyl)-2-methyl-4-pyridinone, its hydrochloride and 1-ethyl-3-hydroxy-2-methyl-4-pyridinone hydrochloride hydrate.
Acta crystallographica. Section C, Crystal structure communications 1993;49 ( Pt 9)():1646-9.
1993: P S Dobbin; Robert C Hider; A D Hall; P D Taylor; P Sarpong; John B Porter; G Xiao; Dick van der Helm
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential.
Journal of medicinal chemistry 1993;36(17):2448-58.
1993: P Lee; N Mohammed; L Marshall; R D Abeysinghe; Robert C Hider; John B Porter; S Singh
Intravenous infusion pharmacokinetics of desferrioxamine in thalassaemic patients.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):640-4.
1993: G Xiao; Dick van der Helm; Robert C Hider; P S Dobbin
3-[1-(Ethylamino)ethylidene]-6-methyl-3H-pyran-2,4-dione.
Acta crystallographica. Section C, Crystal structure communications 1993;49 ( Pt 5)():980-2.
1993: K P Hoyes; Hilary Jones; R D Abeysinghe; Robert C Hider; John B Porter
In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
Experimental hematology 1993;21(1):86-92.
1992: K P Hoyes; Robert C Hider; John B Porter
Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines.
Cancer research 1992;52(17):4591-9.
1992: O R Epemolu; S Singh; Robert C Hider; Lyaquat A Damani
The pharmacokinetics of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rats.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):736-41.
1992: S Singh; N Mohammed; R Ackerman; John B Porter; Robert C Hider
Quantification of desferrioxamine and its iron chelating metabolites by high-performance liquid chromatography and simultaneous ultraviolet-visible/radioactive detection.
Analytical biochemistry 1992;203(1):116-20.
1992: S Singh; R O Epemolu; P S Dobbin; G S Tilbrook; B L Ellis; Lyaquat A Damani; Robert C Hider
Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):256-61.
1992: R O Epemolu; S Singh; Robert C Hider; Lyaquat A Damani
High-performance liquid chromatographic determination of 1,2-diethyl-3-hydroxypyridin-4-one and its 2-(1-hydroxyethyl) metabolite in rat blood.
Journal of chromatography 1992;573(1):178-82.
1991: John B Porter; K P Hoyes; R D Abeysinghe; P N Brooks; E R Huehns; Robert C Hider
Comparison of the subacute toxicity and efficacy of 3-hydroxypyridin-4-one iron chelators in overloaded and nonoverloaded mice.
Blood 1991;78(10):2727-34.
1990: John B Porter; J Morgan; K P Hoyes; L C Burke; E R Huehns; Robert C Hider
Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice.
Blood 1990;76(11):2389-96.
1990: M Streater; P D Taylor; Robert C Hider; J Porter
Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties, and biological activity.
Journal of medicinal chemistry 1990;33(6):1749-55.
1990: S Singh; Robert C Hider; John B Porter
Separation and identification of desferrioxamine and its iron chelating metabolites by high-performance liquid chromatography and fast atom bombardment mass spectrometry: choice of complexing agent and application to biological fluids.
Analytical biochemistry 1990;187(2):212-9.
1990: S Singh; Robert C Hider; John B Porter
A direct method for quantification of non-transferrin-bound iron.
Analytical biochemistry 1990;186(2):320-3.
1990: Robert C Hider; L Ejim; P D Taylor; R Gale; E Huehns; John B Porter
Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia.
Biochemical pharmacology 1990;39(6):1005-12.
1989: John B Porter; K P Hoyes; R Abeysinghe; E R Huehns; Robert C Hider
Animal toxicology of iron chelator L1.
Lancet 1989;2(8655):156.
1989: Robert C Hider; K Lerch
The inhibition of tyrosinase by pyridinones.
The Biochemical journal 1989;257(1):289-90.
1988: John B Porter; M Gyparaki; L C Burke; E R Huehns; P Sarpong; V Saez; Robert C Hider
Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant.
Blood 1988;72(5):1497-503.
1988: S Singh; Robert C Hider
Colorimetric detection of the hydroxyl radical: comparison of the hydroxyl-radical-generating ability of various iron complexes.
Analytical biochemistry 1988;171(1):47-54.
1988: J A Levey; Margery A Barrand; B A Callingham; Robert C Hider
Characteristics of iron(III) uptake by isolated fragments of rat small intestine in the presence of the hydroxypyrones, maltol and ethyl maltol.
Biochemical pharmacology 1988;37(10):2051-7.
1987: M Gyparaki; John B Porter; S Hirani; M Streater; Robert C Hider; E R Huehns
In vivo evaluation of hydroxypyridone iron chelators in a mouse model.
Acta haematologica 1987;78(2-3):217-21.