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Tunda Hidvegi

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Physiology

Disorders

alpha 1-Antitrypsin Deficiency

Co-author Network

Publications

TOP 3
Jianqiang Ding; Govardhana R Yannam; Namita Roy-Chowdhury; Tunda Hidvegi; Hesham Basma; Stephen I Rennard; Ronald J Wong; Yesim Avsar; Chandan Guha; David H Perlmutter; Ira J Fox; Jayanta Roy-Chowdhury
Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.
Tunda Hidvegi; Carolyn Kemp; Amitava Mukherjee; Michael Ewing; David H Perlmutter
The role of autophagy in alpha-1-antitrypsin deficiency.
Tunda Hidvegi; Michael Ewing; Pamela Hale; CS Dippold; Caroline Beckett; Carolyn Kemp; Nicholas Maurice; Amitava Mukherjee; Christina Goldbach; simon simon watkins; George Michalopoulos; David H Perlmutter
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

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All Publications

2011: Jianqiang Ding; Govardhana R Yannam; Namita Roy-Chowdhury; Tunda Hidvegi; Hesham Basma; Stephen I Rennard; Ronald J Wong; Yesim Avsar; Chandan Guha; David H Perlmutter; Ira J Fox; Jayanta Roy-Chowdhury
Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.
The Journal of clinical investigation 2011;121(5):1930-4.
2011: Tunda Hidvegi; Carolyn Kemp; Amitava Mukherjee; Michael Ewing; David H Perlmutter
The role of autophagy in alpha-1-antitrypsin deficiency.
Methods in enzymology 2011;499():33-54.
2010: Tunda Hidvegi; Michael Ewing; Pamela Hale; CS Dippold; Caroline Beckett; Carolyn Kemp; Nicholas Maurice; Amitava Mukherjee; Christina Goldbach; simon simon watkins; George Michalopoulos; David H Perlmutter
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.
Science (New York, N.Y.) 2010;329(5988):229-32.
2007: Tunda Hidvegi; Károly Mirnics; Pamela Hale; Michael Ewing; Caroline Beckett; David H Perlmutter
Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency.
The Journal of biological chemistry 2007;282(38):27769-80.
2006: Takahiro Kamimoto; Shisako Shoji; Tunda Hidvegi; Noboru Mizushima; Kyohei Umebayashi; David H Perlmutter; Tamotsu Yoshimori
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity.
The Journal of biological chemistry 2006;281(7):4467-76.
2005: Tunda Hidvegi; Bela Z Schmidt; Pamela Hale; David H Perlmutter
Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.
The Journal of biological chemistry 2005;280(47):39002-15.
2001: Jeffrey H Teckman; Jon Burrows; Tunda Hidvegi; B Schmidt; Pamela Hale; David H Perlmutter
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
The Journal of biological chemistry 2001;276(48):44865-72.
1999: Antonella Circolo; Gérard Garnier; W Fukuda; X Wang; Tunda Hidvegi; Alexander Szalai; D E Briles; John E Volanakis; Rick A Wetsel; HR Colten
Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.
Immunopharmacology 1999;42(1-3):135-49.
1999: Bela Z Schmidt; N L Fowler; Tunda Hidvegi; David H Perlmutter; HR Colten
Disruption of disulfide bonds is responsible for impaired secretion in human complement factor H deficiency.
The Journal of biological chemistry 1999;274(17):11782-8.
1997: M Matsumoto; W Fukuda; Antonella Circolo; J Goellner; J Strauss-Schoenberger; X Wang; S Fujita; Tunda Hidvegi; D D Chaplin; HR Colten
Abrogation of the alternative complement pathway by targeted deletion of murine factor B.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8720-5.