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Christoph Hiemke

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Elnaz Ostad Haji; Marie-Luise Rao; Gerd Laux; Klaus Mann; Matthias J Müller; Katja Boland; Aleksandra Dragicevic; Miriam Fric; Christoph Hiemke
Potential Cost-effectiveness of Therapeutic Drug Monitoring for Depressed Patients Treated With Citalopram.
Christian Geber; Christoph Hiemke; Elnaz Ostad Haji; Konrad Schlicht; André Tadić
Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder.
Maximilian Gahr; Christoph Hiemke; Makus A Kölle; Roland W Freudenmann; Carlos Schönfeldt-Lecuona
Pregabalin abuse and dependence in Germany: results from a database query.

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2013: Elnaz Ostad Haji; Marie-Luise Rao; Gerd Laux; Klaus Mann; Matthias J Müller; Katja Boland; Aleksandra Dragicevic; Miriam Fric; Christoph Hiemke
Potential Cost-effectiveness of Therapeutic Drug Monitoring for Depressed Patients Treated With Citalopram.
Therapeutic drug monitoring 2013;35(3):396-401.
2013: Christian Geber; Christoph Hiemke; Elnaz Ostad Haji; Konrad Schlicht; André Tadić
Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder.
Therapeutic drug monitoring 2013;35(3):279-82.
2013: Maximilian Gahr; Christoph Hiemke; Makus A Kölle; Roland W Freudenmann; Carlos Schönfeldt-Lecuona
Pregabalin abuse and dependence in Germany: results from a database query.
European journal of clinical pharmacology 2013;69(6):1335-42.
2013: Martina Hahn; Christoph Hiemke; Julia Reiff; Dieter F Braus
[Drug-drug-interactions in psychiatry].
Psychiatrische Praxis 2013;40(3):154-8.
2013: Tanja Veselinovic; Gerald Zernig; Ruben Gur; Christoph Hiemke; Holger Schorn; Ingo B Vernaleken; Gerhard Gründer
Effects of antipsychotic treatment on cognition in healthy subjects.
Journal of psychopharmacology (Oxford, England) 2013;27(4):374-85.
2013: M M Schmid; Bernhard Connemann; Roland W Freudenmann; M Fuchs; M Gahr; Christoph Hiemke; F Keller; W Kratzer; Carlos Schönfeldt-Lecuona
Non-fatal and fatal liver failure associated with valproic acid.
Pharmacopsychiatry 2013;46(2):63-8.
2013: Christoph Hiemke; Mohamed Shams
Phenotyping and genotyping of drug metabolism to guide pharmacotherapy in psychiatry.
Current drug delivery 2013;10(1):46-53.
2013: Cosima Rhein; Peter Zill; Mazda Adli; Ulrich Hegerl; Christoph Hiemke; Roland Mergl; Hans-Jürgen Möller; Christiane Mühle; Julia Naumann; Martin Reichel; Johannes Kornhuber
The Acid Sphingomyelinase Sequence Variant p.A487V Is Not Associated With Decreased Levels of Enzymatic Activity.
JIMD reports 2013;8():1-6.
2012: Carolina Araya-Callís; Nashat Abumaria; Christoph Hiemke; Gabriele Flugge
Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus.
Psychopharmacology 2012;224(1):209-22.
2012: Ulrich Schmitt; Jürgen Drewe; Christoph Hiemke; Katrin M Kirschbaum; Manisha Kusch-Poddar; Birk Poller; Heike Gutmann
In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes.
Pharmacology, biochemistry, and behavior 2012;102(2):312-20.
2012: Pierre Baumann; Patricia Berney; Hartmut Kirchherr; Christoph Hiemke
Flupentixol: relevance of stereoselective therapeutic drug monitoring.
Psychopharmacology 2012;221(4):719-20.
2012: Maximilian Gahr; Ingo M Gunst; Christoph Hiemke; Bernhard Connemann; Roland W Freudenmann; Carlos Schönfeldt-Lecuona
"Krokodil":revival of an old drug with new problems.
Substance use & misuse 2012;47(7):861-3.
2012: Y Schoenfelder; Christoph Hiemke; Ulrich Schmitt
Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms.
Journal of neuroendocrinology 2012;24(5):809-17.
2012: N Dreimüller; K Boland; B Bondy; Aleksandra Dragicevic; Gerd Laux; Klaus Lieb; Wolfgang Maier; Matthias J Müller; Marie Luise Rao; Marcella Rietschel; Joachim Röschke; A Tadić; P Zill; Christoph Hiemke
The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression.
Pharmacopsychiatry 2012;45(3):108-13.
2012: Marcel Gerbaulet; Christoph Hiemke; Alice Engel; Norbert Dahmen
High venlafaxine serum levels after prior fluoxetine medication.
Journal of clinical psychopharmacology 2012;32(2):295-7.
2012: Maximilian Gahr; Ingo M Gunst; Christoph Hiemke; Bernhard Connemann; Roland W Freudenmann; Carlos Schönfeldt-Lecuona
Desomorphine goes "crocodile".
Journal of addictive diseases 2012;31(4):407-12.
2012: Christoph Hiemke; Bruno Pfuhlmann
Interactions and monitoring of antipsychotic drugs.
Handbook of experimental pharmacology 2012;(212):241-65.
2012: Elnaz Ostad Haji; Christoph Hiemke; Bruno Pfuhlmann
Therapeutic drug monitoring for antidepressant drug treatment.
Current pharmaceutical design 2012;18(36):5818-27.
2012: David Holthoewer; Ulrich Schmitt; Florian Schuck; Kristina Endres; Christoph Hiemke; Falk Fahrenholz
Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein.
Neuro-degenerative diseases 2012;10(1-4):224-8.
2012: Christian Schmahl; Mathias Berger; Sonja Brünen; Peter Deibler; Sabine Herpertz; Christoph Hiemke; Nikolaus Kleindienst; Klaus Lieb; Matthias Limberger; Petra Ludäscher; Jana Mauchnik; Markus Reicherzer; Martin Bohus
Evaluation of naltrexone for dissociative symptoms in borderline personality disorder.
International clinical psychopharmacology 2012;27(1):61-8.
2012: Nadine Dreimüller; Christoph Hiemke; Klaus Lieb; Dirk Peetz; Konrad Friedrich Schlicht; Liudmyla Borysenko; Stefanie Wagner; André Tadić
Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression.
Neuropharmacology 2012;62(1):264-9.
2011: Tanja Veselinović; Gerald Zernig; Ruben Gur; Christoph Hiemke; Katharina Schiffl; Holger Schorn; Ingo Vernaleken; Gerhard Gründer
Effects of antipsychotic treatment on psychopathology and motor symptoms. A placebo-controlled study in healthy volunteers.
Psychopharmacology 2011;218(4):733-48.
2011: Sonja Brünen; Christoph Hiemke; Philippe D Vincent; Pierre Baumann; Ursula Havemann-Reinecke
Therapeutic drug monitoring for drugs used in the treatment of substance-related disorders: literature review using a therapeutic drug monitoring appropriateness rating scale.
Therapeutic drug monitoring 2011;33(5):561-72.
2011: Christoph Hiemke; E Jaquenoud Sirot; H Kirchherr; Gerd Laux; U C Lutz; T Messer; M J Müller; Bruno Pfuhlmann; B Rambeck; Peter Riederer; B Schoppek; J Stingl; M Uhr; S Ulrich; Roland Waschgler; P Baumann; N Bergemann; Andreas Conca; O Dietmaier; K Egberts; M Fric; Manfred Gerlach; C Greiner; G Gründer; Ekkehard Haen; Ursula Havemann-Reinecke; Gerald Zernig
AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011.
Pharmacopsychiatry 2011;44(6):195-235.
2011: Christoph Hiemke; E Jaquenoud Sirot; H Kirchherr; G Laux; U C Lutz; T Messer; M J Müller; Bruno Pfuhlmann; B Rambeck; Peter Riederer; B Schoppek; J Stingl; M Uhr; S Ulrich; Roland Waschgler; P Baumann; N Bergemann; Andreas Conca; O Dietmaier; K Egberts; M Fric; M Gerlach; C Greiner; G Gründer; Ekkehard Haen; Ursula Havemann-Reinecke; G Zernig
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011.
Pharmacopsychiatry 2011;44(6):195-235.
2011: Vincent Eggart; Christoph Hiemke; Gerald Zernig
"There is no dose-response relationship in psychopharmacotherapy" vs "pharmacotherapy in psychiatry is based on ligand-receptor interaction": a unifying hypothesis and the need for plasma concentration based clinical trials.
Psychopharmacology 2011;217(2):297-300.
2011: Britta Haenisch; Christoph Hiemke; Heinz Bönisch
Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters.
Psychopharmacology 2011;217(2):289-95.
2011: Elnaz Ostad Haji; André Tadić; Stefanie Wagner; Aleksandra Dragicevic; Matthias J Müller; Katja Boland; Marie Luise Rao; Miriam Fric; Gerd Laux; Christoph Hiemke
Association between citalopram serum levels and clinical improvement of patients with major depression.
Journal of clinical psychopharmacology 2011;31(3):281-6.
2011: Mirjam Hemmelmann; Christiane Knoth; Ulrich Schmitt; Mareli Allmeroth; Dorothea Moderegger; Matthias Barz; Kaloian Koynov; Christoph Hiemke; Frank Rösch; Rudolf Zentel
HPMA based amphiphilic copolymers mediate central nervous effects of domperidone.
Macromolecular rapid communications 2011;32(9-10):712-7.
2011: Louise Karlsson; Christoph Hiemke; Björn Carlsson; Martin Josefsson; Johan Ahlner; Finn Bengtsson; Ulrich Schmitt; Fredrik C Kugelberg
Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model.
Psychopharmacology 2011;215(2):367-77.
2011: André Tadić; Stefanie Wagner; Konrad Friedrich Schlicht; Dirk Peetz; Liudmyla Borysenko; Nadine Dreimüller; Christoph Hiemke; Klaus Lieb
The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study.
Progress in neuro-psychopharmacology & biological psychiatry 2011;35(2):415-20.
2011: V Stieffenhofer; H Saglam; I Schmidtmann; H Silver; Christoph Hiemke; A Konrad
Clozapine plasma level monitoring for prediction of rehospitalization schizophrenic outpatients.
Pharmacopsychiatry 2011;44(2):55-9.
2011: Ulrich Schmitt; Dianne E Lee; Matthias M Herth; Markus Piel; Hans-Georg Buchholz; Frank Roesch; Christoph Hiemke; Hartmut Lueddens; Fabian Debus
P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ.
Neuropsychobiology 2011;63(3):183-90.
2011: André Tadić; Stefanie Wagner; Stanislav Gorbulev; Norbert Dahmen; Christoph Hiemke; Dieter F Braus; Klaus Lieb
Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder.
BMC psychiatry 2011;11():16.
2010: Katrin M Kirschbaum; Manfred Uhr; David Holthoewer; Christian Namendorf; Claus Pietrzik; Christoph Hiemke; Ulrich Schmitt
Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice.
Neuropharmacology 2010;59(6):474-9.
2010: Louise Karlsson; Ulrich Schmitt; Martin Josefsson; Björn Carlsson; Johan Ahlner; Finn Bengtsson; Fredrik C Kugelberg; Christoph Hiemke
Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010;20(9):632-40.
2010: Barbara Drueke; Maren Boecker; Sonja Schlaegel; Olaf Moeller; Christoph Hiemke; Gerhard Gründer; Siegfried Gauggel
Serotonergic modulation of response inhibition and re-engagement? Results of a study in healthy human volunteers.
Human psychopharmacology 2010;25(6):472-80.
2010: Ingo Vernaleken; Hildegard Janouschek; Mardjan Raptis; Sandra Hellmann; Tanja Veselinovic; Anno Bröcheler; Christian Boy; Paul Cumming; Christoph Hiemke; Frank Rösch; Wolfgang M Schäfer; Gerhard Gründer
Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(7):951-60.
2010: Yasmin Nazirizadeh; Friederike Vogel; Wolfgang Bader; Ekkehard Haen; Bruno Pfuhlmann; Gerhard Gründer; Michael Paulzen; Markus Schwarz; Gerald Zernig; Christoph Hiemke
Serum concentrations of paliperidone versus risperidone and clinical effects.
European journal of clinical pharmacology 2010;66(8):797-803.
2010: Viktoria Stieffenhofer; Christoph Hiemke
[Pharmacogenetics, therapeutic drug monitoring and non compliance].
Therapeutische Umschau. Revue thérapeutique 2010;67(6):309-15.
2010: Michael Rougemont; Sven Ulrich; Christoph Hiemke; Emmanuelle Corruble; Pierre Baumann
French summaries of product characteristics: content in relation to therapeutic monitoring of psychotropic drugs.
Fundamental & clinical pharmacology 2010;24(3):377-84.
2010: Ulrike Böer; Christine Noll; Irmgard Cierny; Doris Krause; Christoph Hiemke; Willhart Knepel
A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.
European journal of pharmacology 2010;633(1-3):33-8.
2010: Ulrich Lutz; Christoph Hiemke; Gerlinde Wiatr; Gisbert Farger; Jörg Arand; Dirk Wildgruber
Aripiprazole in pregnancy and lactation: a case report.
Journal of clinical psychopharmacology 2010;30(2):204-5.
2010: Ion Anghelescu; Christoph Klawe; Peter Singer; Christoph Fehr; Christoph Hiemke; Arnim Quante; Francesca Regen; Norbert Dahmen; Armin Szegedi
Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2010;11(2 Pt 2):382-9.
2010: Sonja Brünen; Ralf Krüger; Susann Finger; Felix Korf; Falk Kiefer; Klaus Wiedemann; Karl J Lackner; Christoph Hiemke
Determination of naltrexone and 6beta-naltrexol in human blood: comparison of high-performance liquid chromatography with spectrophotometric and tandem-mass-spectrometric detection.
Analytical and bioanalytical chemistry 2010;396(3):1249-57.
2010: Igor Yakushev; Peter Bartenstein; Thomas Siessmeier; Christoph Hiemke; Armin Scheurich; Johannes Lotz; Andreas Fellgiebel; Matthias J Müller
Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease.
Dementia and geriatric cognitive disorders 2010;30(3):245-53.
2010: André Tadić; Stanislav Gorbulev; Norbert Dahmen; Christoph Hiemke; Dieter F Braus; Joachim Röschke; Dietrich van Calker; Daniel Wachtlin; Kai Kronfeld; Thorsten Gorbauch; Monika Seibert-Grafe; Klaus Lieb
Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial.
Trials 2010;11():21.
2009: Barbara Drueke; Julia Baetz; Maren Boecker; Olaf Moeller; Christoph Hiemke; Gerhard Gründer; Siegfried Gauggel
Differential effects of escitalopram on attention: a placebo-controlled, double-blind cross-over study.
Psychopharmacology 2009;207(2):213-23.
2009: Michael Paulzen; Christoph Hiemke; Gerhard Gründer
Plasma levels and cerebrospinal fluid penetration by duloxetine in a patient with a non-fatal overdose during a suicide attempt.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(10):1431-2.
2009: C Waldschmitt; F Vogel; Bruno Pfuhlmann; Christoph Hiemke
Duloxetine serum concentrations and clinical effects. Data from a therapeutic drug monitoring (TDM) survey.
Pharmacopsychiatry 2009;42(5):189-93.
2009: Olaf Schulte-Herbrüggen; Eberhard Fuchs; Nashat Abumaria; Annerose Ziegler; Heidi Danker-Hopfe; Christoph Hiemke; Rainer Hellweg
Effects of escitalopram on the regulation of brain-derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress.
Journal of neuroscience research 2009;87(11):2551-60.
2009: Bruno Pfuhlmann; Christoph Hiemke; Stephan Unterecker; Rainer Burger; Armin Schmidtke; Peter Riederer; Jürgen Deckert; Burkhard Jabs
Toxic clozapine serum levels during inflammatory reactions.
Journal of clinical psychopharmacology 2009;29(4):392-4.
2009: Borros Arneth; Mohamed EL Houseiny El Sebeay Shams; Christoph Hiemke; Sebastian Härtter
Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene.
Clinical biochemistry 2009;42(12):1282-90.
2009: Matthias J Müller; F X Eich; B Regenbogen; Julia Sachse; Sebastian Härtter; Christoph Hiemke
Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder.
Journal of psychopharmacology (Oxford, England) 2009;23(3):278-86.
2009: Peter Tonn; Silja C Reuter; Christoph Hiemke; Norbert Dahmen
High mirtazapine plasma levels in infant after breast feeding: case report and review of the literature.
Journal of clinical psychopharmacology 2009;29(2):191-2.
2009: Peter Schlotterbeck; Ralf Saur; Christoph Hiemke; Gerd Gründer; Thomas Vehren; Tilo Kircher; Dirk Leube
Low concentration of ziprasidone in human milk: a case report.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(3):437-8.
2009: Friederike Vogel; Reinhard Gansmüller; Thomas Leiblein; Otto Dietmaier; Hans Wassmuth; Gerhard Gründer; Christoph Hiemke
The use of ziprasidone in clinical practice: analysis of pharmacokinetic and pharmacodynamic aspects from data of a drug monitoring survey.
European psychiatry : the journal of the Association of European Psychiatrists 2009;24(3):143-8.
2009: Axel Becker; Gisela Grecksch; Gerald Zernig; Elisabeth Ladstaetter; Christoph Hiemke; Ulrich Schmitt
Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia.
Psychopharmacology 2009;202(4):579-87.
2009: Katrin M Kirschbaum; Christoph Hiemke; Ulrich Schmitt
Rotarod impairment: catalepsy-like screening test for antipsychotic side effects.
The International journal of neuroscience 2009;119(10):1509-22.
2008: Michael Kellner; Cüneyt Demiralay; Christoph Muhtz; Jana Husemann; Wiebke Kölsch; Christoph Hiemke; Alexander Yassouridis; Klaus Wiedemann
No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter.
Psychiatry research 2008;161(3):339-43.
2008: Ingo Vernaleken; Christine Fellows; Hildegard Janouschek; Anno Bröcheler; Tanja Veselinovic; Christian Landvogt; Christian Boy; Hans-Georg Buchholz; Katja Spreckelmeyer; Peter Bartenstein; Paul Cumming; Christoph Hiemke; Frank Rösch; Wolfgang Schäfer; Dean F Wong; Gerhard Gründer
Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone).
Journal of clinical psychopharmacology 2008;28(6):608-17.
2008: P M Schlotterbeck; T Vehren; S Milenovic; Christoph Hiemke; T Kircher; Dirk T Leube
No influence of dialysis on mirtazapine - a case report.
Pharmacopsychiatry 2008;41(6):259-60.
2008: Ulrike Böer; Irmgard Cierny; Doris Krause; Annette Heinrich; Hongyin Lin; Georg Mayr; Christoph Hiemke; Willhart Knepel
Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(10):2407-15.
2008: Christian J Bachmann; Anette Rieger-Gies; Monika Heinzel-Gutenbrunner; Christoph Hiemke; Helmut Remschmidt; Frank M Theisen
Large variability of aripiprazole and dehydroaripiprazole serum concentrations in adolescent patients with schizophrenia.
Therapeutic drug monitoring 2008;30(4):462-6.
2008: Gerhard Gründer; Christine Fellows; Hildegard Janouschek; Tanja Veselinovic; Christian Boy; Anno Bröcheler; Katrin M Kirschbaum; Sandra Hellmann; Katja M Spreckelmeyer; Christoph Hiemke; Frank Rösch; Wolfgang M Schaefer; Ingo Vernaleken
Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study.
The American journal of psychiatry 2008;165(8):988-95.
2008: Rafal Rygula; Nashat Abumaria; Ursula Havemann-Reinecke; Eckart Rüther; Christoph Hiemke; Gerald Zernig; Eberhard Fuchs; Gabriele Flügge
Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam.
Behavioural pharmacology 2008;19(3):183-96.
2008: Katrin M Kirschbaum; Stefanie Henken; Christoph Hiemke; Ulrich Schmitt
Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice.
Behavioural brain research 2008;188(2):298-303.
2008: Iryna Moldovanova; Christoph Schroeder; Giris Jacob; Christoph Hiemke; Andre Diedrich; Friedrich C Luft; Jens Jordan
Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women.
Hypertension 2008;51(4):1203-9.
2008: Christoph Hiemke
Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?
European archives of psychiatry and clinical neuroscience 2008;258 Suppl 1():21-7.
2008: Christoph Hiemke
Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry.
European journal of clinical pharmacology 2008;64(2):159-66.
2008: Christoph Hiemke
[Individualized treatment with tricyclic antidepressives. The pharmacogenetics of depression].
Pharmazie in unserer Zeit 2008;37(3):234-40.
2007: Christine Waldschmitt; Friederike Vogel; Christian Maurer; Christoph Hiemke
Measurement of duloxetine in blood using high-performance liquid chromatography with spectrophotometric detection and column switching.
Therapeutic drug monitoring 2007;29(6):767-72.
2007: Matthias J Müller; Boris Regenbogen; Sebastian Härtter; Franz-Xaver Eich; Christoph Hiemke
Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia.
Journal of psychiatric research 2007;41(8):673-9.
2007: Boldizsár Czéh; Jeanine I H Müller-Keuker; Rafal Rygula; Nashat Abumaria; Christoph Hiemke; Enrico Domenici; Eberhard Fuchs
Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(7):1490-503.
2007: Nashat Abumaria; Rafal Rygula; Christoph Hiemke; Eberhard Fuchs; Ursula Havemann-Reinecke; Eckart Rüther; Gabriele Flügge
Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(6-7):417-29.
2007: Christine Greiner; Christoph Hiemke; Wolfgang Bader; Ekkehard Haen
Determination of citalopram and escitalopram together with their active main metabolites desmethyl(es-)citalopram in human serum by column-switching high performance liquid chromatography (HPLC) and spectrophotometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;848(2):391-4.
2007: Gerald Zernig; Karen Ng; Christoph Hiemke; Alois Saria
Therapeutic drug monitoring-based clozapine dosing recommendations.
Therapeutic drug monitoring 2007;29(1):130-1.
2007: Andreas Fellgiebel; Matthias J Müller; Christoph Hiemke; Peter Bartenstein; Matthias Schreckenberger
Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolism.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2007;8(2):123-6.
2006: Ulrich Schmitt; Christoph Hiemke; Falk Fahrenholz; Anja Schroeder
Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice.
Behavioural brain research 2006;175(2):278-84.
2006: Klaus Mann; Christoph Hiemke; Johannes Lotz; Lutz G Schmidt; Karl J Lackner; David Bates
Appropriateness of plasma level determinations for lithium and valproate in routine care of psychiatric inpatients with affective disorders.
Journal of clinical psychopharmacology 2006;26(6):671-3.
2006: Rafal Rygula; Nashat Abumaria; Enrico Domenici; Christoph Hiemke; Eberhard Fuchs
Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats.
Behavioural brain research 2006;174(1):188-92.
2006: Markus Schwarz; Christoph Hiemke; Pierre Baumann
Clinical relevance of TDM of SSRIs.
Therapeutic drug monitoring 2006;28(5):716-7; author reply 717.
2006: Mohamed EL Houseiny El Sebeay Shams; B Arneth; Christoph Hiemke; Aleksandra Dragicevic; Matthias J Müller; R Kaiser; K Lackner; Sebastian Härtter
CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.
Journal of clinical pharmacy and therapeutics 2006;31(5):493-502.
2006: Boldizsár Czéh; Mária Simon; Barthel Schmelting; Christoph Hiemke; Eberhard Fuchs
Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(8):1616-26.
2006: Ulrich Schmitt; A Abou El-Ela; L J Guo; Hristos Glavinas; Peter Krajcsi; J M Baron; C Tillmann; Christoph Hiemke; Peter Langguth; Sebastian Härtter
Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp).
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(7):787-801.
2006: Pierre Baumann; Christoph Hiemke; Sven Ulrich; Gabriel Eckermann; H L Kuss; Gerd Laux; B Müller-Oerlingenhausen; Marie Luise Rao; Peter Riederer; Gerald Zernig
[Therapeutic drug monitoring (TDM) of psychotropic drugs: a consensus guideline of the AGNP-TDM group].
Revue médicale suisse 2006;2(67):1413-8, 1420-2, 1424-6.
2006: Gerhard Gründer; Christian Landvogt; Ingo Vernaleken; Hans-Georg Buchholz; Jasmin Ondracek; Thomas Siessmeier; Sebastian Härtter; Mathias Schreckenberger; Peter Stoeter; Christoph Hiemke; Frank Rösch; Dean F Wong; Peter Bartenstein
The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(5):1027-35.
2006: Matthias J Müller; B Regenbogen; Julia Sachse; Franz-Xaver Eich; Sebastian Härtter; Christoph Hiemke
Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring study.
Pharmacopsychiatry 2006;39(2):41-6.
2006: Johannes Kornhuber; Harald Weigmann; J Röhrich; Jens Wiltfang; Stefan Bleich; Ingolf Meineke; Robert Zöchling; Sebastian Härtter; Peter Riederer; Christoph Hiemke
Region specific distribution of levomepromazine in the human brain.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(3):387-97.
2006: Klaus Mann; Christoph Hiemke; Lutz G Schmidt; David Bates
Appropriateness of therapeutic drug monitoring for antidepressants in routine psychiatric inpatient care.
Therapeutic drug monitoring 2006;28(1):83-8.
2006: Rafal Rygula; Nashat Abumaria; Gabriele Flügge; Christoph Hiemke; Eberhard Fuchs; Eckart Rüther; Ursula Havemann-Reinecke
Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats.
Behavioural pharmacology 2006;17(1):19-29.
2006: Klaus Mann; Wolfgang Rossbach; Matthias J Müller; Florian Müller-Siecheneder; Tobias Pott; Iris Linde; Ralf W Dittmann; Christoph Hiemke
Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine.
Psychoneuroendocrinology 2006;31(2):256-64.
2006: Julia Sachse; Johannes Köller; Sebastian Härtter; Christoph Hiemke
Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;830(2):342-8.
2005: Katrin M Kirschbaum; Matthias J Müller; Gerald Zernig; Alois Saria; Arian Mobascher; Jaroslav Malevani; Christoph Hiemke
Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection.
Clinical chemistry 2005;51(9):1718-21.
2005: Ion Anghelescu; Christoph Klawe; Christoph Fehr; Peter Singer; Alexandra Schleicher; Hubertus Himmerich; Christoph Hiemke; Norbert Dahmen; Armin Szegedi
The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology.
Addictive behaviors 2005;30(6):1135-43.
2005: Maria Gilles; Michael Deuschle; S Kellner; Mohamed EL Houseiny El Sebeay Shams; Bertram Krumm; Sebastian Härtter; Isabella Heuser; Christoph Hiemke
Paroxetine serum concentrations in depressed patients and response to treatment.
Pharmacopsychiatry 2005;38(3):118-21.
2005: Katja Grasmäder; Petra Louise Verwohlt; Kai-Uwe Kühn; Christine Frahnert; Christoph Hiemke; Aleksandra Dragicevic; Olrik von Widdern; Astrid Zobel; Wolfgang Maier; Marie Luise Rao
Relationship between mirtazapine dose, plasma concentration, response, and side effects in clinical practice.
Pharmacopsychiatry 2005;38(3):113-7.
2005: Julia Sachse; Sebastian Härtter; Christoph Hiemke
Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection.
Therapeutic drug monitoring 2005;27(2):158-62.
2005: Norbert Dahmen; Markus Völp; Peter Singer; Christoph Hiemke; Armin Szegedi
Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism.
Psychiatric genetics 2005;15(1):13-6.
2005: Pierre Baumann; Sven Ulrich; Gabriel Eckermann; Manfred Gerlach; Hans-Joachim Kuss; Gerd Laux; Bruno Müller-Oerlinghausen; Marie Luise Rao; Peter Riederer; Gerald Zernig; Christoph Hiemke
The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants.
Dialogues in clinical neuroscience 2005;7(3):231-47.
2004: Ingo Vernaleken; Thomas Siessmeier; Hans-Georg Buchholz; Sebastian Härtter; Christoph Hiemke; Peter Stoeter; Frank Rösch; Peter Bartenstein; Gerhard Gründer
High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2004;7(4):421-30.
2004: Pierre Baumann; Christoph Hiemke; Sven Ulrich; Gabriel Eckermann; I Gaertner; Manfred Gerlach; Hans-Joachim Kuss; Gerd Laux; Bruno Müller-Oerlinghausen; Marie Luise Rao; Peter Riederer; Gerald Zernig
The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry.
Pharmacopsychiatry 2004;37(6):243-65.
2004: Gerald Zernig; Theresa Lechner; Karin Kramer-Reinstadler; Hartmann Hinterhuber; Christoph Hiemke; Alois Saria
What the clinician still has to be reminded of.
Therapeutic drug monitoring 2004;26(5):582.
2004: Sebastian Härtter; Bernhard Connemann; Carlos Schönfeldt-Lecuona; Julia Sachse; Christoph Hiemke
Elevated quetiapine serum concentrations in a patient treated concomitantly with doxepin, lorazepam, and pantoprazole.
Journal of clinical psychopharmacology 2004;24(5):568-71.
2004: Katja Grasmäder; Petra Louise Verwohlt; Kai-Uwe Kühn; Aleksandra Dragicevic; Olrik von Widdern; Astrid Zobel; Christoph Hiemke; Marcella Rietschel; Wolfgang Maier; Ulrich Jaehde; Marie Luise Rao
Population pharmacokinetic analysis of mirtazapine.
European journal of clinical pharmacology 2004;60(7):473-80.
2004: Amal Abou El Ela; Sebastian Härtter; Ulrich Schmitt; Christoph Hiemke; Hilde Spahn-Langguth; Peter Langguth
Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates.
The Journal of pharmacy and pharmacology 2004;56(8):967-75.
2004: Sandra Heller; Christoph Hiemke; Gabriele Stroba; Anette Rieger-Gies; Elisabeth Daum-Kreysch; Julia Sachse; Sebastian Härtter
Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service.
Therapeutic drug monitoring 2004;26(4):459-61.
2004: Katja Grasmäder; Petra Louise Verwohlt; Marcella Rietschel; Aleksandra Dragicevic; Matthias Müller; Christoph Hiemke; Nikolaus Freymann; Astrid Zobel; Wolfgang Maier; Marie Luise Rao
Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting.
European journal of clinical pharmacology 2004;60(5):329-36.
2004: Rolf Postina; Anja Schroeder; Ilse Dewachter; Jürgen Bohl; Ulrich Schmitt; Elzbieta Kojro; Claudia Prinzen; Kristina Endres; Christoph Hiemke; Manfred Blessing; Pascaline Flamez; Antoine Dequenne; Emile Godaux; Fred Van Leuven; Falk Fahrenholz
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.
The Journal of clinical investigation 2004;113(10):1456-64.
2004: Pierre Baumann; Christoph Hiemke; Sven Ulrich; I Gaertner; Marie Luise Rao; Gabriel Eckermann; Manfred Gerlach; Hans-Joachim Kuss; Gerd Laux; Bruno Müller-Oerlinghausen; Peter Riederer; Gerald Zernig
Therapeutic monitoring of psychotropic drugs: an outline of the AGNP-TDM expert group consensus guideline.
Therapeutic drug monitoring 2004;26(2):167-70.
2004: Christoph Hiemke; Aleksandra Dragicevic; Gerhard Gründer; Sebastian Hätter; Julia Sachse; Ingo Vernaleken; Matthias J Müller
Therapeutic monitoring of new antipsychotic drugs.
Therapeutic drug monitoring 2004;26(2):156-60.
2004: Mohamed EL Houseiny El Sebeay Shams; Christoph Hiemke; Sebastian Härtter
Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum.
Therapeutic drug monitoring 2004;26(1):78-84.
2003: Sebastian Härtter; Sabine Hüwel; Tina Lohmann; Amal Abou El Ela; Peter Langguth; Christoph Hiemke; Hans-Joachim Galla
How does the benzamide antipsychotic amisulpride get into the brain?--An in vitro approach comparing amisulpride with clozapine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1916-22.
2003: Matthias J Müller; Aleksandra Dragicevic; Mirijam Fric; I Gaertner; Katja Grasmäder; Sebastian Härtter; E Hermann; Hans-Joachim Kuss; Gerd Laux; W Oehl; Marie Luise Rao; N Rollmann; Harald Weigmann; M Weber-Labonte; Christoph Hiemke
Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?
Pharmacopsychiatry 2003;36(3):98-104.
2003: Katja Grasmäder; Petra Louise Lohmann; Hans-Joachim Kuss; G Laux; Christoph Hiemke; Marie Luise Rao
[Therapeutic drug monitoring of antidepressives--therapeutic and health economics advantages].
Medizinische Monatsschrift für Pharmazeuten 2003;26(5):162-4.
2003: Sebastian Härtter; Christoph Hiemke
[Therapeutic drug monitoring of new antidepressives and antipsychotics].
Medizinische Monatsschrift für Pharmazeuten 2003;26(5):160-2.
2003: Julia Sachse; Sebastian Härtter; Harald Weigmann; Christoph Hiemke
Automated determination of amisulpride by liquid chromatography with column switching and spectrophotometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;784(2):405-10.
2003: Michael Grözinger; Aleksandra Dragicevic; Christoph Hiemke; Mohamed EL Houseiny El Sebeay Shams; Matthias J Müller; Sebastian Härtter
Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.
Pharmacopsychiatry 2003;36(1):3-6.
2003: Gerhard Gründer; Thomas Siessmeier; Markus Piel; Ingo Vernaleken; Hans-Georg Buchholz; Yun Zhou; Christoph Hiemke; Dean F Wong; Frank Rösch; Peter Bartenstein
Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(1):109-16.
2002: Christoph Hiemke; Avi Peled ; Mahmoud Jabarin; Jack Hadjez; Harald Weigmann; Sebastian Härtter; Ilan Modai; Michael Ritsner; Henry Silver
Fluvoxamine augmentation of olanzapine in chronic schizophrenia: pharmacokinetic interactions and clinical effects.
Journal of clinical psychopharmacology 2002;22(5):502-6.
2002: Christian Plewnia; Julia Hoppe; Christoph Hiemke; Mathias Bartels; Leonardo Cohen; Christian Gerloff
Enhancement of human cortico-motoneuronal excitability by the selective norepinephrine reuptake inhibitor reboxetine.
Neuroscience letters 2002;330(3):231-4.
2002: Christian Lange-Asschenfeldt; Harald Weigmann; Christoph Hiemke; Klaus Mann
Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology.
Journal of clinical psychopharmacology 2002;22(4):440-1.
2002: Ulrich Schmitt; Christoph Hiemke
Tiagabine, a gamma-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze.
Behavioural brain research 2002;133(2):391-4.
2002: Sebastian Härtter; Gunnel Tybring; Thomas Friedberg; Harald Weigmann; Christoph Hiemke
The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.
Pharmaceutical research 2002;19(7):1034-7.
2002: Norbert Dahmen; Peter Jungblut; Viola Fischer; Martina Schrank; Stefan Reuss; Dan Rujescu; Christoph Hiemke
Detection of TOAD-64 in adult rat brain as revealed by two-dimensional protein gel electrophoresis followed by MALDI mass spectrometry possible modulatory effect of chronic haloperidol treatment.
Progress in neuro-psychopharmacology & biological psychiatry 2002;26(4):693-8.
2002: Ulrich Schmitt; Hartmut Lüddens; Christoph Hiemke
Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(5-6):871-80.
2002: Ulrich Schmitt; Susanna Waldhofer; Tamara Weigelt; Christoph Hiemke
Free-choice ethanol consumption under the influence of GABAergic drugs in rats.
Alcoholism, clinical and experimental research 2002;26(4):457-62.
2002: Henry Silver; Nili Shlomo; Christoph Hiemke; Marie-Luise Rao; Michael Ritsner; Ilan Modai
Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2002;12(2):141-4.
2002: Marja van Kampen; Marian Kramer; Christoph Hiemke; Gabriele Flügge; Eberhard Fuchs
The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disorders.
Stress (Amsterdam, Netherlands) 2002;5(1):37-46.
2002: Sabine Germeyer; Andrea Birke; Ulrich Schmitt; Norbert Dahmen; Christoph Hiemke; Ursula Havemann-Reinecke
New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypies.
Brain research 2002;926(1-2):1-9.
2002: Sebastian Härtter; Christoph Hiemke
[Important to atypical antipsychotics: pharmacokinetics, interaction potential and therapeutic drug monitoring].
Pharmazie in unserer Zeit 2002;31(6):546-57.
2002: Ralf Schlösser; Gerhard Gründer; Ion Anghelescu; A Hillert; S Ewald-Gründer; Christoph Hiemke; Otto Benkert
Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels.
Neuropsychobiology 2002;46(1):33-40.
2001: T A Rao; Christoph Hiemke; Katja Grasmäder; P Baumann
[Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring].
Fortschritte der Neurologie-Psychiatrie 2001;69(12):580-2.
2001: Marie Luise Rao; Christoph Hiemke; Katja Grasmäder; P Baumann
[Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring].
Fortschritte der Neurologie-Psychiatrie 2001;69(11):510-7.
2001: Harald Weigmann; Sebastian Härtter; S Maehrlein; Werner Kiefer; G Krämer; Gerd Dannhardt; Christoph Hiemke
Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):63-71.
2001: Harald Weigmann; S Gerek; A Zeisig; M Müller; Sebastian Härtter; Christoph Hiemke
Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring service.
Therapeutic drug monitoring 2001;23(4):410-3.
2001: Christoph Fehr; A Schleicher; Armin Szegedi; Ion Anghelescu; Christoph Klawe; Christoph Hiemke; Norbert Dahmen
Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy.
Progress in neuro-psychopharmacology & biological psychiatry 2001;25(5):965-82.
2001: Ulrich Schmitt; Hartmut Lüddens; Christoph Hiemke
Behavioral analysis indicates benzodiazepine-tolerance mediated by the benzodiazepine binding-site at the GABA(A)-receptor.
Progress in neuro-psychopharmacology & biological psychiatry 2001;25(5):1145-60.
2001: Norbert Dahmen; Matthias J Müller; Sabine Germeyer; Dan Rujescu; I Anghelescu; Christoph Hiemke; Hermann Wetzel
Genetic polymorphisms of the dopamine D2 and D3 receptor and neuroleptic drug effects in schizophrenic patients.
Schizophrenia research 2001;49(1-2):223-5.
2001: Sebastian Härtter; X Wang; Harald Weigmann; Thomas Friedberg; Michael Arand; Franz Oesch; Christoph Hiemke
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.
Journal of clinical psychopharmacology 2001;21(2):167-74.
2001: Matthias J Müller; Sebastian Härtter; D Köhler; Christoph Hiemke
Serum levels of sulpiride enantiomers after oral treatment with racemic sulpiride in psychiatric patients: a pilot study.
Pharmacopsychiatry 2001;34(1):27-32.
2000: Christoph Fehr; N Grintschuk; Armin Szegedi; Ion Anghelescu; Christoph Klawe; Peter Singer; Christoph Hiemke; Norbert Dahmen
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.
Psychiatry research 2000;97(1):1-10.
2000: Harald Weigmann; Sebastian Härtter; M Bagli; Christoph Hiemke
Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2000;10(5):401-5.
2000: Michael Grözinger; Sebastian Härtter; X Wang; Joachim Röschke; Christoph Hiemke; D M Rose
Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile.
Archives of general psychiatry 2000;57(8):812-3.
2000: Christoph Fehr; Gerhard Gründer; Christoph Hiemke; Norbert Dahmen
Increase in serum clomipramine concentrations caused by valproate.
Journal of clinical psychopharmacology 2000;20(4):493-4.
2000: Christoph Fehr; Armin Szegedi; Ion Anghelescu; Christoph Klawe; Christoph Hiemke; Norbert Dahmen
Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.
Psychiatric genetics 2000;10(2):59-65.
2000: Norbert Dahmen; T Pauly; Armin Szegedi; Hermann Wetzel; Ion Anghelescu; K Ferdinand; Christoph Hiemke
Adenylyl cyclase activity is increased in younger, but decreased in older, alcoholic patients after detoxification.
Alcohol and alcoholism (Oxford, Oxfordshire) 2000;35(3):249-54.
2000: Ralf Schlösser; Hermann Wetzel; H Dörr; Wolfgang Rossbach; Christoph Hiemke; Otto Benkert
Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers.
Psychoneuroendocrinology 2000;25(4):377-88.
2000: Sebastian Härtter; Harald Weigmann; Christoph Hiemke
Automated determination of reboxetine by high-performance liquid chromatography with column-switching and ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications 2000;740(1):135-40.
2000: Marja van Kampen; U Schmitt; Christoph Hiemke; Eberhard Fuchs
Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews.
Pharmacology, biochemistry, and behavior 2000;65(3):539-46.
2000: Ulrich Schmitt; Hartmut Lüddens; Christoph Hiemke
Behavioral effects of GABA(A) receptor stimulation and GABA-transporter inhibition.
Pharmacology, biochemistry, and behavior 2000;65(2):351-6.
2000: Christoph Hiemke; Sebastian Härtter
Pharmacokinetics of selective serotonin reuptake inhibitors.
Pharmacology & therapeutics 2000;85(1):11-28.
2000: Sebastian Härtter; Michael Grözinger; Harald Weigmann; Joachim Röschke; Christoph Hiemke
Increased bioavailability of oral melatonin after fluvoxamine coadministration.
Clinical pharmacology and therapeutics 2000;67(1):1-6.
1999: M Ficková; Norbert Dahmen; Christoph Fehr; Christoph Hiemke
Quantitation of GABA transporter 3 (GAT3) mRNA in rat brain by competitive RT-PCR.
Brain research. Brain research protocols 1999;4(3):341-50.
1999: Marian Kramer; Christoph Hiemke; Eberhard Fuchs
Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects.
Neuroscience and biobehavioral reviews 1999;23(7):937-47.
1999: Armin Szegedi; Ion Anghelescu; J Wiesner; S Schlegel; Harald Weigmann; Sebastian Härtter; Christoph Hiemke; Hermann Wetzel
Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial.
Pharmacopsychiatry 1999;32(4):148-53.
1999: Michael Grözinger; Sebastian Härtter; Christoph Hiemke; Joachim Röschke
Oxybutynin enhances the metabolism of clomipramine and dextrorphan possibly by induction of a cytochrome P450 isoenzyme.
Journal of clinical psychopharmacology 1999;19(3):287-9.
1999: Stefan Reuss; B Hermes; E Fuchs; Christoph Hiemke
Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamus.
Neuroscience letters 1999;266(1):29-32.
1999: Ulrich Schmitt; Christoph Hiemke
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
Behavioural pharmacology 1999;10(2):131-7.
1999: Claas-Hinrich Lammers; Michael Deuschle; Harald Weigmann; Sebastian Härtter; Christoph Hiemke; C Heese; Isabella Heuser
Coadministration of clozapine and fluvoxamine in psychotic patients--clinical experience.
Pharmacopsychiatry 1999;32(2):76-7.
1999: Harald Weigmann; Sebastian Härtter; Viola Fischer; Norbert Dahmen; Christoph Hiemke
Distribution of clozapine and desmethylclozapine between blood and brain in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1999;9(3):253-6.
1999: T Pauly; Norbert Dahmen; Armin Szegedi; Hermann Wetzel; G F Böl; K Ferdinand; Christoph Hiemke
Blood ethanol levels and adenylyl cyclase activity in lymphocytes of alcoholic patients.
Biological psychiatry 1999;45(4):489-93.
1999: Ulrich Schmitt; Norbert Dahmen; Viola Fischer; Harald Weigmann; Marie Luise Rao; Stefan Reuss; Christoph Hiemke
Chronic oral haloperidol and clozapine in rats: A behavioral evaluation.
Neuropsychobiology 1999;39(2):86-91.
1999: Christoph Fehr; M Ficková; Christoph Hiemke; Norbert Dahmen
Rapid cloning of cDNA ends polymerase chain reaction of G-protein-coupled receptor kinase 6: an improved method to determine 5'- and 3'-cDNA ends.
Brain research. Brain research protocols 1999;3(3):242-51.
1999: Gerhard Gründer; Hermann Wetzel; Ralf Schlösser; Ion Anghelescu; A Hillert; K Lange; Christoph Hiemke; Otto Benkert
Neuroendocrine response to antipsychotics: effects of drug type and gender.
Biological psychiatry 1999;45(1):89-97.
1998: Ion Anghelescu; Armin Szegedi; S Schlegel; Harald Weigmann; Christoph Hiemke; Hermann Wetzel
Combination treatment with clozapine and paroxetine in schizophrenia: safety and tolerability data from a prospective open clinical trial.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1998;8(4):315-20.
1998: Armin Szegedi; Ion Anghelescu; T Pauly; Norbert Dahmen; Matthias J Müller; Hermann Wetzel; Christoph Hiemke
Activity of the adenylyl cyclase in lymphocytes of male alcoholic patients is state dependent.
Alcoholism, clinical and experimental research 1998;22(9):2073-9.
1998: Ulrich Schmitt; Christoph Hiemke
Combination of open field and elevated plus-maze: a suitable test battery to assess strain as well as treatment differences in rat behavior.
Progress in neuro-psychopharmacology & biological psychiatry 1998;22(7):1197-215.
1998: Viola Fischer; Ulrich Schmitt; Harald Weigmann; B Von Keller; Stefan Reuss; Christoph Hiemke; Norbert Dahmen
Chronical haloperidol and clozapine treatment in rats: differential RNA display analysis, behavioral studies and serum level determination.
Progress in neuro-psychopharmacology & biological psychiatry 1998;22(7):1129-39.
1998: Sebastian Härtter; Hermann Wetzel; E Hammes; M Torkzadeh; Christoph Hiemke
Serum concentrations of fluvoxamine and clinical effects. A prospective open clinical trial.
Pharmacopsychiatry 1998;31(5):199-200.
1998: Sebastian Härtter; B Jensen; Christoph Hiemke; M Leal; Harald Weigmann; K Unger
Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of carbamazepine and its main metabolites.
Journal of chromatography. B, Biomedical sciences and applications 1998;712(1-2):253-8.
1998: Sebastian Härtter; Hermann Wetzel; E Hammes; M Torkzadeh; Christoph Hiemke
Nonlinear pharmacokinetics of fluvoxamine and gender differences.
Therapeutic drug monitoring 1998;20(4):446-9.
1998: J Sandmann; Bernd Lörch; B Bandelow; Sebastian Härtter; P Winter; Christoph Hiemke; Otto Benkert
Fluvoxamine or placebo in the treatment of panic disorder and relationship to blood concentrations of fluvoxamine.
Pharmacopsychiatry 1998;31(4):117-21.
1998: Harald Weigmann; Sebastian Härtter; Christoph Hiemke
Automated determination of clomipramine and its major metabolites in human and rat serum by high-performance liquid chromatography with on-line column-switching.
Journal of chromatography. B, Biomedical sciences and applications 1998;710(1-2):227-33.
1998: Ulrich Schmitt; Christoph Hiemke
Strain differences in open-field and elevated plus-maze behavior of rats without and with pretest handling.
Pharmacology, biochemistry, and behavior 1998;59(4):807-11.
1998: Michael Grözinger; Sebastian Härtter; Christoph Hiemke; E U Griese; Joachim Röschke
Interaction of modafinil and clomipramine as comedication in a narcoleptic patient.
Clinical neuropharmacology 1998;21(2):127-9.
1998: Hermann Wetzel; Ion Anghelescu; Armin Szegedi; J Wiesner; Harald Weigmann; S Härter; Christoph Hiemke
Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study.
Journal of clinical psychopharmacology 1998;18(1):2-9.
1998: Sebastian Härtter; J Dingemanse; D Baier; G Ziegler; Christoph Hiemke
Inhibition of dextromethorphan metabolism by moclobemide.
Psychopharmacology 1998;135(1):22-6.
1997: D Köhler; Sebastian Härtter; K Fuchs; W Sieghart; Christoph Hiemke
CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication.
Pharmacogenetics 1997;7(6):453-61.
1997: Christoph Fehr; M Fickova; Christoph Hiemke; Stefan Reuss; Norbert Dahmen
Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues.
Brain research. Molecular brain research 1997;49(1-2):278-82.
1997: Ralf Schlösser; S Schlegel; Christoph Hiemke; Otmar Nickel; Andreas Bockisch; Marie Luise Rao; K Hahn
[123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects.
Psychiatry research 1997;75(2):103-14.
1997: Norbert Dahmen; Christoph Fehr; Stefan Reuss; Christoph Hiemke
Stimulation of immediate early gene expression by desipramine in rat brain.
Biological psychiatry 1997;42(5):317-23.
1997: Harald Weigmann; J Bierbrauer; Sebastian Härtter; Christoph Hiemke
Automated determination of clozapine and major metabolites in serum and urine.
Therapeutic drug monitoring 1997;19(4):480-8.
1997: M Banger; B Hermes; Sebastian Härtter; Christoph Hiemke
Monitoring serum concentrations of clomipramine and metabolites: fluorescence polarization immunoassay versus high performance liquid chromatography.
Pharmacopsychiatry 1997;30(4):128-32.
1997: Michael Deuschle; Sebastian Härtter; Christoph Hiemke; H Standhardt; Isabella Heuser
Doxepin and its metabolites in plasma and cerebrospinal fluid in depressed patients.
Psychopharmacology 1997;131(1):19-22.
1996: Christoph Hiemke; M Stolp; Stefan Reuss; Andrea Wevers; S Reinhardt; Alfred Maelicke; S Schlegel; H Schröder
Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes.
Neuroscience letters 1996;214(2-3):171-4.
1996: Norbert Dahmen; Viola Fischer; P Hödl; D Rujescu; Stefan Reuss; G D Bartoszyk; Christoph Hiemke
Induction of c-fos gene expression by the selective sigma receptor ligand EMD 57445 in rat brain.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1996;6(3):237-43.
1996: Sebastian Härtter; J Dingemanse; D Baier; G Ziegler; Christoph Hiemke
The role of cytochrome P450 2D6 in the metabolism of moclobemide.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1996;6(3):225-30.
1996: Klaus Mann; H Bauer; Christoph Hiemke; Joachim Röschke; Hermann Wetzel; Otto Benkert
Acute, subchronic and discontinuation effects of zopiclone on sleep EEG and nocturnal melatonin secretion.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1996;6(3):163-8.
1996: M Banger; Christoph Hiemke; M Haupt; R Knuppen
Excretion of 2- and 3-monomethyl ethers of 2-hydroxyestrogens in healthy male volunteers.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(2):193-7.
1996: Sebastian Härtter; D Baier; J Dingemanse; G Ziegler; Christoph Hiemke
Automated determination of dextromethorphan and its main metabolites in human plasma by high-performance liquid chromatography and column switching.
Therapeutic drug monitoring 1996;18(3):297-303.
1996: Armin Szegedi; Hermann Wetzel; M Leal; Sebastian Härtter; Christoph Hiemke
Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data.
The Journal of clinical psychiatry 1996;57(6):257-64.
1996: Eberhard Fuchs; M Kramer; B Hermes; P Netter; Christoph Hiemke
Psychosocial stress in tree shrews: clomipramine counteracts behavioral and endocrine changes.
Pharmacology, biochemistry, and behavior 1996;54(1):219-28.
1996: S Schlegel; Ralf Schlösser; Christoph Hiemke; Otmar Nickel; Andreas Bockisch; Klaus Hahn
Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT.
Psychopharmacology 1996;124(3):285-7.
1995: Armin Szegedi; J Wiesner; Christoph Hiemke
Improved efficacy and fewer side effects under clozapine treatment after addition of fluvoxamine.
Journal of clinical psychopharmacology 1995;15(2):141-3.
1995: Gerhard Gründer; Hermann Wetzel; A Hillert; E Jochum; Christoph Hiemke; Otto Benkert
The neuroendocrinological profile of roxindole, a dopamine autoreceptor agonist, in schizophrenic patients.
Psychopharmacology 1995;117(4):472-8.
1995: Christoph Hiemke; R Brunner; E Hammes; H Müller; K H Meyer zum Büschenfelde; Ansgar W Lohse
Circadian variations in antigen-specific proliferation of human T lymphocytes and correlation to cortisol production.
Psychoneuroendocrinology 1995;20(3):335-42.
1995: Sebastian Härtter; Michael Arand; Franz Oesch; Christoph Hiemke
Non-competitive inhibition of clomipramine N-demethylation by fluvoxamine.
Psychopharmacology 1995;117(2):149-53.
1995: A Jussofie; I Körner; C Schell; Christoph Hiemke
Time course of the effects of steroid hormone deprivation elicited by ovariectomy or ovariectomy plus adrenalectomy on the affinity and density of GABA binding sites in distinct rat brain areas.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1995;103(3):196-204.
1994: A Jussofie; A Schmiz; Christoph Hiemke
Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain.
Psychopharmacology 1994;116(4):469-74.
1994: W Seiler; Hermann Wetzel; A Hillert; G Schöllnhammer; M Langer; U Barlage; Christoph Hiemke
Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application.
Psychopharmacology 1994;116(4):457-63.
1994: B Hermes; Christoph Hiemke; Stefan Reuss
Day- and nighttime content of monoamines and their metabolites in the pineal gland of rat and hamster.
Neuroscience letters 1994;179(1-2):119-22.
1994: Christoph Hiemke
[Paroxetine: pharmacokinetics and pharmacodynamics].
Fortschritte der Neurologie-Psychiatrie 1994;62 Suppl 1():2-8.
1994: Hermann Wetzel; J Wiesner; Christoph Hiemke; Otto Benkert
Acute antagonism of dopamine D2-like receptors by amisulpride: effects on hormone secretion in healthy volunteers.
Journal of psychiatric research 1994;28(5):461-73.
1994: Sebastian Härtter; B Hermes; Armin Szegedi; Christoph Hiemke
Automated determination of paroxetine and its main metabolite by column switching and on-line high-performance liquid chromatography.
Therapeutic drug monitoring 1994;16(4):400-6.
1994: Christoph Hiemke; Harald Weigmann; Sebastian Härtter; Norbert Dahmen; Hermann Wetzel; H Müller
Elevated levels of clozapine in serum after addition of fluvoxamine.
Journal of clinical psychopharmacology 1994;14(4):279-81.
1994: Marie Luise Rao; U Staberock; P Baumann; Christoph Hiemke; A Deister; C Cuendet; M Amey; Sebastian Härtter; M Kraemer
Monitoring tricyclic antidepressant concentrations in serum by fluorescence polarization immunoassay compared with gas chromatography and HPLC.
Clinical chemistry 1994;40(6):929-33.
1994: W Seiler; Hermann Wetzel; A Hillert; G Schöllnhammer; Otto Benkert; Christoph Hiemke
Plasma levels of benperidol, prolactin, and homovanillic acid after intravenous versus two different kinds of oral application of the neuroleptic in schizophrenic patients.
Experimental and clinical endocrinology 1994;102(4):326-33.
1993: Sebastian Härtter; Hermann Wetzel; E Hammes; Christoph Hiemke
Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients.
Psychopharmacology 1993;110(3):302-8.
1992: Harald Weigmann; Christoph Hiemke
Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography 1992;583(2):209-16.
1992: Sebastian Härtter; Hermann Wetzel; Christoph Hiemke
Automated determination of fluvoxamine in plasma by column-switching high-performance liquid chromatography.
Clinical chemistry 1992;38(10):2082-6.
1992: H Müller; Christoph Hiemke; E Hammes; G Hess
Sub-acute effects of interferon-alpha 2 on adrenocorticotrophic hormone, cortisol, growth hormone and prolactin in humans.
Psychoneuroendocrinology 1992;17(5):459-65.
1992: Sebastian Härtter; Christoph Hiemke
Column switching and high-performance liquid chromatography in the analysis of amitriptyline, nortriptyline and hydroxylated metabolites in human plasma or serum.
Journal of chromatography 1992;578(2):273-82.
1992: Christoph Hiemke; M Banger; R Kohsik; M Hundt; R Ghraf
Actions of sex hormones on the brain.
Progress in neuro-psychopharmacology & biological psychiatry 1992;16(3):377-88.
1991: H Müller; E Hammes; Christoph Hiemke; G Hess
Interferon-alpha-2-induced stimulation of ACTH and cortisol secretion in man.
Neuroendocrinology 1991;54(5):499-503.
1991: S Süss; W Seiler; Christoph Hiemke; G Schöllnhammer; Hermann Wetzel; A Hillert
Determination of benperidol and its reduced metabolite in human plasma by high-performance liquid chromatography and electrochemical detection.
Journal of chromatography 1991;565(1-2):363-73.
1991: M Jüptner; A Jussofie; Christoph Hiemke
Effects of ovariectomy and steroid replacement on GABAA receptor binding in female rat brain.
The Journal of steroid biochemistry and molecular biology 1991;38(2):141-7.
1991: Christoph Hiemke; A Jussofie; M Jüptner
Evidence that 3 alpha-hydroxy-5 alpha-pregnan-20-one is a physiologically relevant modulator of GABA-ergic neurotransmission.
Psychoneuroendocrinology 1991;16(6):517-23.
1990: M Banger; Christoph Hiemke; R Knuppen; P Ball; M Haupt; Klaus Wiedemann
Formation and metabolism of catecholestrogens in depressed patients.
Biological psychiatry 1990;28(8):685-96.
1990: M Jüptner; Christoph Hiemke
Sex differences in GABAA receptor binding in rat brain measured by an improved in vitro binding assay.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;81(2):297-302.
1987: Martin C Michel; A Rother; Christoph Hiemke; R Ghraf
Inhibition of synaptosomal high-affinity uptake of dopamine and serotonin by estrogen agonists and antagonists.
Biochemical pharmacology 1987;36(19):3175-80.
1987: Christoph Hiemke; A Schmid; D Büttner; R Ghraf
Improved model for the induction of proestrus-like gonadotropin surges in long-term ovariectomized rats.
Journal of steroid biochemistry 1987;28(3):357-9.
1985: Christoph Hiemke; D Bruder; M C Michel; R Ghraf
Time-dependent effects of oestradiol and progesterone on hypothalamic catecholamine turnover in ovariectomized rats.
The Journal of endocrinology 1985;106(3):303-9.
1985: Christoph Hiemke; B Poetz; R Ghraf
Antioestrogen inhibition of oestradiol-induced alterations in hypothalamic noradrenaline turnover.
The Journal of endocrinology 1985;106(1):37-42.
1985: Christoph Hiemke; D Bruder; B Poetz; R Ghraf
Sex-specific effects of estradiol on hypothalamic noradrenaline turnover in gonadectomized rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1985;59(1):68-72.
1984: Christoph Hiemke; R Ghraf
Interaction of non-steroidal antiestrogens with dopamine receptor binding.
Journal of steroid biochemistry 1984;21(6):663-7.
1984: M Michel; Christoph Hiemke; R Ghraf
Preferential uptake of norepinephrine into dopaminergic terminals of a synaptosomal preparation from rat cerebral cortex.
Brain research 1984;301(1):149-52.
1984: Christoph Hiemke; R Ghraf
Re-establishment of stimulatory estradiol effects on luteinizing hormone secretion in long term ovariectomized rats.
Brain research 1984;294(1):182-5.
1983: R Ghraf; M Michel; Christoph Hiemke; R Knuppen
Competition by monophenolic estrogens and catecholestrogens for high-affinity uptake of [3H](-)-norepinephrine into synaptosomes from rat cerebral cortex and hypothalamus.
Brain research 1983;277(1):163-8.
1983: Christoph Hiemke; M Banger; R Ghraf; R Knuppen
Do catecholestrogens interact with the in vitro binding of radioligands to catecholamine receptors?
Journal of steroid biochemistry 1983;19(4):1469-74.
1983: Christoph Hiemke; D Frohne; D Bruder; R Ghraf
Effects of oestradiol benzoate and progesterone on luteinizing hormone release and catecholamine turnover in the preoptic-hypothalamic brain area of ovariectomized rats.
The Journal of endocrinology 1983;97(3):437-45.
1983: Christoph Hiemke; R Ghraf
Distribution and properties of thiol S-methyltransferase in rat brain.
Journal of neurochemistry 1983;40(2):592-4.
1982: Christoph Hiemke; R Ghraf
Effects of short-term exposure to catecholestrogens on catecholamine turnover in the preoptic-hypothalamic brain of ovariectomized rats.
Brain research 1982;240(2):295-301.
1982: R Ghraf; K Schneider; J Kirchhoff; Christoph Hiemke
Subcellular distribution of 3 alpha-hydroxysteroid dehydrogenase and antiestrogen action on androgen-metabolizing enzymes in rat pituitary gland.
Journal of neurochemistry 1982;38(4):876-83.
1982: R Ghraf; K Schneider; J Kirchhoff; Christoph Hiemke
The action of 5 alpha-dihydrotestosterone and antiandrogens on the activities of 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase in the pituitary gland of gonadectomized rats.
Journal of steroid biochemistry 1982;16(4):545-52.
1981: Christoph Hiemke; R Ghraf
Regional distribution of methionine adenosyltransferase in rat brain as measured by a rapid radiochemical method.
Journal of neurochemistry 1981;37(3):613-8.