Kanji Higashio

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Tomoyasu Akihiro; Higashio Kanji; Kanomata Kazuhiro; Goto Masaaki; Kodaira Kunihiko; Serizawa Hiroko; Suda Tatsuo; Nakamura Atsushi; Nojima Junya; Fukuda Toru; Katagiri Takenobu
Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs.
Kodaira Kunihiko; Imada Mana; Goto Masaaki; Tomoyasu Akihiro; Fukuda Toru; Kamijo Ryutaro; Suda Tatsuo; Higashio Kanji; Katagiri Takenobu
Purification and identification of a BMP-like factor from bovine serum.
Tomoyasu Akihiro; Higashio Kanji
[Osteoclastogenesis inhibitory factor/osteoprotegerin(OCIF/OPG)]

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2007: Tomoyasu Akihiro; Higashio Kanji; Kanomata Kazuhiro; Goto Masaaki; Kodaira Kunihiko; Serizawa Hiroko; Suda Tatsuo; Nakamura Atsushi; Nojima Junya; Fukuda Toru; Katagiri Takenobu
Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs.
Biochemical and biophysical research communications 2007;361(1):62-7.
2006: Kodaira Kunihiko; Imada Mana; Goto Masaaki; Tomoyasu Akihiro; Fukuda Toru; Kamijo Ryutaro; Suda Tatsuo; Higashio Kanji; Katagiri Takenobu
Purification and identification of a BMP-like factor from bovine serum.
Biochemical and biophysical research communications 2006;345(3):1224-31.
2004: Tomoyasu Akihiro; Higashio Kanji
[Osteoclastogenesis inhibitory factor/osteoprotegerin(OCIF/OPG)]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 2():560-5.
2003: Enomoto Hirayuki; Shiojiri Satoko; Hoshi Kazuto; Furuichi Tatsuya; Fukuyama Ryo; Yoshida Carolina A; Kanatani Naoko; Nakamura Reiko; Mizuno Atsuko; Zanma Akira; Yano Kazuki; Yasuda Hisataka; Higashio Kanji; Takada Kenji; Komori Toshihisa
Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene.
The Journal of biological chemistry 2003;278(26):23971-7.
2002: Yamashita Teruhito; Okada Seiji; Higashio Kanji; Nabeshima Yo-Ichi; Noda Masaki
Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype.
Endocrinology 2002;143(12):4711-7.
2002: Suda Tatsuo; Shima Nobuyuki; Higashio Kanji
[Merger of bone biology and immunology]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(13):1837-43.
2002: Mizuno Atsuko; Kanno Takeshi; Hoshi Masaki; Shibata Osamu; Yano Kazuki; Fujise Nobuaki; Kinosaki Masahiko; Yamaguchi Kyoji; Tsuda Eisuke; Murakami Akihiko; Yasuda Hisataka; Higashio Kanji
Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis.
Journal of bone and mineral metabolism 2002;20(6):337-44.
2002: Mochizuki Shin-ichi; Fujise Nobuaki; Higashio Kanji; Tsuda Eisuke
Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats.
Journal of bone and mineral metabolism 2002;20(1):14-20.
2001: Yano K; Shibata O; Mizuno A; Kobayashi F; Higashio K; Morinaga T; Tsuda E
Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy.
Biochemical and biophysical research communications 2001;288(1):217-24.
2001: Quinn J M; Itoh K; Udagawa N; Hausler K; Yasuda H; Shima N; Mizuno A; Higashio K; Takahashi N; Suda T; Martin T J; Gillespie M T
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1787-94.
2001: Itoh K; Udagawa N; Katagiri T; Iemura S; Ueno N; Yasuda H; Higashio K; Quinn J M; Gillespie M T; Martin T J; Suda T; Takahashi N
Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.
Endocrinology 2001;142(8):3656-62.
2001: Ihara H; Denhardt D T; Furuya K; Yamashita T; Muguruma Y; Tsuji K; Hruska K A; Higashio K; Enomoto S; Nifuji A; Rittling S R; Noda M
Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.
The Journal of biological chemistry 2001;276(16):13065-71.
2001: Yano K; Nakagawa N; Yasuda H; Tsuda E; Higashio K
Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor.
Journal of bone and mineral metabolism 2001;19(6):365-72.
2000: Oh S H; Miyazaki M; Kouchi H; Inoue Y; Sakaguchi M; Tsuji T; Shima N; Higashio K; Namba M
Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro.
Biochemical and biophysical research communications 2000;279(2):500-4.
2000: Shiota A; Yamashita Y; Fujise N; Masunaga H; Yasuda H; Higashio K
A deleted form of human hepatocyte growth factor stimulates hepatic lipogenesis and lipoprotein synthesis in rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(5):443-52.
2000: Udagawa N; Takahashi N; Yasuda H; Mizuno A; Itoh K; Ueno Y; Shinki T; Gillespie M T; Martin T J; Higashio K; Suda T
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function.
Endocrinology 2000;141(9):3478-84.
2000: Kobayashi K; Takahashi N; Jimi E; Udagawa N; Takami M; Kotake S; Nakagawa N; Kinosaki M; Yamaguchi K; Shima N; Yasuda H; Morinaga T; Higashio K; Martin T J; Suda T
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.
The Journal of experimental medicine 2000;191(2):275-86.
1999: Udagawa N; Takahashi N; Jimi E; Matsuzaki K; Tsurukai T; Itoh K; Nakagawa N; Yasuda H; Goto M; Tsuda E; Higashio K; Gillespie M T; Martin T J; Suda T
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand.
Bone 1999;25(5):517-23.
1999: Arisawa H; Yamashita Y; Ogawa H; Masunaga H; Higashio K
Deleted form of hepatocyte growth factor ameliorates the mortality rate of severe thermal injury in rats.
Surgery 1999;126(5):925-32.
1999: Nakagawa N; Yasuda H; Yano K; Mochizuki S i; Kobayashi N; Fujimoto H; Shima N; Morinaga T; Chikazu D; Kawaguchi H; Higashio K
Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells.
Biochemical and biophysical research communications 1999;265(1):158-63.
1999: Nakagawa N; Yasuda H; Yano K; Mochizuki S i; Kobayashi N; Fujimoto H; Yamaguchi K; Shima N; Morinaga T; Higashio K
Basic fibroblast growth factor inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D(3) through suppressing the production of osteoclast differentiation factor.
Biochemical and biophysical research communications 1999;265(1):45-50.
1999: Yasuda H; Shima N; Nakagawa N; Yamaguchi K; Kinosaki M; Goto M; Mochizuki S I; Tsuda E; Morinaga T; Udagawa N; Takahashi N; Suda T; Higashio K
A novel molecular mechanism modulating osteoclast differentiation and function.
Bone 1999;25(1):109-13.
1999: Yano K; Tsuda E; Washida N; Kobayashi F; Goto M; Harada A; Ikeda K; Higashio K; Yamada Y
Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(4):518-27.
1999: Kodaira K; Kodaira K; Mizuno A; Yasuda H; Shima N; Murakami A; Ueda M; Higashio K
Cloning and characterization of the gene encoding mouse osteoclast differentiation factor.
Gene 1999;230(1):121-7.
1999: Kinosaki M; Yamaguchi K; Yamashita Y; Uematsu Y; Aihara H; Masunaga H; Morinaga T; Higashio K
A mutant of deleted variant of hepatocyte growth factor (dHGF) with alanine substitution in the N-terminal basic region has higher activity in vivo.
Biochemical and biophysical research communications 1999;254(2):363-7.
1999: Uematsu Y; Fujise N; Kohsaka K; Masunaga H; Higashio K
Effective administration route for the deleted form of hepatocyte growth factor To exert its pharmacological effects.
Journal of pharmaceutical sciences 1999;88(1):131-5.
1998: Nakagawa N; Kinosaki M; Yamaguchi K; Shima N; Yasuda H; Yano K; Morinaga T; Higashio K
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.
Biochemical and biophysical research communications 1998;253(2):395-400.
1998: Akatsu T; Murakami T; Ono K; Nishikawa M; Tsuda E; Mochizuki S I; Fujise N; Higashio K; Motoyoshi K; Yamamoto M; Nagata N
Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy.
Bone 1998;23(6):495-8.
1998: Yano K; Tsuda E; Ueda M; Higashio K
Natural hepatocyte growth factor (HGF) from human serum and a bound form of recombinant HGF with heparan sulfate are indistinguishable in their physicochemical properties.
International journal of biological macromolecules 1998;23(3):227-35.
1998: Shima N; Stolz D B; Miyazaki M; Gohda E; Higashio K; Michalopoulos G K
Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor.
Journal of cellular physiology 1998;177(1):130-6.
1998: Akatsu T; Murakami T; Nishikawa M; Ono K; Shinomiya N; Tsuda E; Mochizuki S; Yamaguchi K; Kinosaki M; Higashio K; Yamamoto M; Motoyoshi K; Nagata N
Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the interaction of stromal cells with osteoclast.
Biochemical and biophysical research communications 1998;250(2):229-34.
1998: Yamamoto M; Murakami T; Nishikawa M; Tsuda E; Mochizuki S; Higashio K; Akatsu T; Motoyoshi K; Nagata N
Hypocalcemic effect of osteoclastogenesis inhibitory factor/osteoprotegerin in the thyroparathyroidectomized rat.
Endocrinology 1998;139(9):4012-5.
1998: Kinosaki M; Yamaguchi K; Murakami A; Morinaga T; Ueda M; Higashio K
Analysis of deleted variant of hepatocyte growth factor by alanine scanning mutagenesis: identification of residues essential for its biological function and generation of mutants with enhanced mitogenic activity on rat hepatocytes.
FEBS letters 1998;434(1-2):165-70.
1998: Nagoshi S; Yasuda H; Suda J; Yamanobe F; Ohno A; Higashio K; Fujiwara K
Hepatocyte apoptosis and hepatic expression of transforming growth factor-beta1 mRNA during involution of hyperplastic rat liver induced by hepatocyte growth factor.
Journal of gastroenterology and hepatology 1998;13(8):786-93.
1998: Mizuno A; Murakami A; Nakagawa N; Yasuda H; Tsuda E; Morinaga T; Higashio K
Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis.
Gene 1998;215(2):339-43.
1998: Morinaga T; Nakagawa N; Yasuda H; Tsuda E; Higashio K
Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor.
European journal of biochemistry / FEBS 1998;254(3):685-91.
1998: Tsuda E; Higashio K
[Osteoclastogenesis inhibitory factor (OCIF)/OPG]
Nippon rinsho. Japanese journal of clinical medicine 1998;56(6):1435-9.
1998: Mizuno A; Amizuka N; Irie K; Murakami A; Fujise N; Kanno T; Sato Y; Nakagawa N; Yasuda H; Mochizuki S; Gomibuchi T; Yano K; Shima N; Washida N; Tsuda E; Morinaga T; Higashio K; Ozawa H
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Biochemical and biophysical research communications 1998;247(3):610-5.
1998: Tsukii K; Shima N; Mochizuki S; Yamaguchi K; Kinosaki M; Yano K; Shibata O; Udagawa N; Yasuda H; Suda T; Higashio K
Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone.
Biochemical and biophysical research communications 1998;246(2):337-41.
1998: Matsuzaki K; Udagawa N; Takahashi N; Yamaguchi K; Yasuda H; Shima N; Morinaga T; Toyama Y; Yabe Y; Higashio K; Suda T
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
Biochemical and biophysical research communications 1998;246(1):199-204.
1998: Kinosaki M; Yamaguchi K; Murakami A; Ueda M; Morinaga T; Higashio K
Identification of heparin-binding stretches of a naturally occurring deleted variant of hepatocyte growth factor (dHGF).
Biochimica et biophysica acta 1998;1384(1):93-102.
1998: Tomoyasu A; Goto M; Fujise N; Mochizuki S; Yasuda H; Morinaga T; Tsuda E; Higashio K
Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.
Biochemical and biophysical research communications 1998;245(2):382-7.
1998: Yamashita Y; Shiota A; Fujise N; Ogawa H; Masunaga H; Yasuda H; Higashio K
Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(3):359-60.
1998: Yasuda H; Shima N; Nakagawa N; Yamaguchi K; Kinosaki M; Mochizuki S; Tomoyasu A; Yano K; Goto M; Murakami A; Tsuda E; Morinaga T; Higashio K; Udagawa N; Takahashi N; Suda T
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3597-602.
1998: Yasuda H; Shima N; Nakagawa N; Mochizuki S I; Yano K; Fujise N; Sato Y; Goto M; Yamaguchi K; Kuriyama M; Kanno T; Murakami A; Tsuda E; Morinaga T; Higashio K
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Endocrinology 1998;139(3):1329-37.
1998: Yamaguchi K; Kinosaki M; Goto M; Kobayashi F; Tsuda E; Morinaga T; Higashio K
Characterization of structural domains of human osteoclastogenesis inhibitory factor.
The Journal of biological chemistry 1998;273(9):5117-23.
1998: Masunaga H; Fujise N; Shiota A; Ogawa H; Sato Y; Imai E; Yasuda H; Higashio K
Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries.
European journal of pharmacology 1998;342(2-3):267-79.
1997: Masunaga H; Fujise N; Yamashita Y; Shiota A; Yasuda H; Higashio K
Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis.
Liver 1997;17(4):192-7.
1997: Tsuda E; Goto M; Mochizuki S; Yano K; Kobayashi F; Morinaga T; Higashio K
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.
Biochemical and biophysical research communications 1997;234(1):137-42.
1996: Yasuda H; Imai E; Shiota A; Fujise N; Morinaga T; Higashio K
Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats.
Hepatology (Baltimore, Md.) 1996;24(3):636-42.
1996: Masunaga H; Fujise N; Shiota A; Yamashita Y; Yasuda H; Higashio K
Amelioration of disordered hepatic protein synthesis by the deleted form of hepatocyte growth factor in models of liver failure in rats.
The Journal of pharmacy and pharmacology 1996;48(8):876-9.
1994: Shima N; Tsuda E; Goto M; Yano K; Hayasaka H; Ueda M; Higashio K
Hepatocyte growth factor and its variant with a deletion of five amino acids are distinguishable in their biological activity and tertiary structure.
Biochemical and biophysical research communications 1994;200(2):808-15.
1993: Higashio K; Shima N
Tumor cytotoxic activity of HGF-SF.
EXS 1993;65():351-68.
1992: Shima N; Higashio K
[Structure and biological property of fibroblast-derived tumor cytotoxic factor (F-TCF)]
Nippon rinsho. Japanese journal of clinical medicine 1992;50(8):1962-6.
1992: Suzuki A; Mitsuda S; Higashio K; Kumasaka T
Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone.
Biochimica et biophysica acta 1992;1133(2):167-71.
1991: Shima N; Nagao M; Ogaki F; Tsuda E; Murakami A; Higashio K
Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein.
Biochemical and biophysical research communications 1991;180(2):1151-8.
1991: Suzuki A; Mitsuda S; Higashio K; Kumasaka T
Participation of phospholipase A2 in induction of tissue plasminogen activator (t-PA) production by human fibroblast, IMR-90 cells, stimulated by proteose peptone.
Thrombosis research 1991;64(2):191-202.
1991: Morimoto A; Okamura K; Hamanaka R; Sato Y; Shima N; Higashio K; Kuwano M
Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture.
Biochemical and biophysical research communications 1991;179(2):1042-9.
1991: Shima N; Higashio K; Ogaki H; Okabe K
ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases.
Gastroenterologia Japonica 1991;26(4):477-82.
1991: Mitsuda S; Kobayashi N; Matsuda Y; Itagaki Y; Suzuki A; Kumazawa E; Higashio K; Kawanishi G
Enhancement of tissue plasminogen activator production from human normal fibroblast IMR-90 cells by limitation of cell growth.
Applied microbiology and biotechnology 1991;35(4):504-9.
1991: Shima N; Itagaki Y; Nagao M; Yasuda H; Morinaga T; Higashio K
A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro.
Cell biology international reports 1991;15(5):397-408.
1991: Itagaki Y; Yasuda H; Morinaga T; Mitsuda S; Higashio K
Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells.
Agricultural and biological chemistry 1991;55(5):1225-32.
1991: Mitsuda S; Matsuda Y; Kobayashi N; Suzuki A; Itagaki Y; Kumazawa E; Higashio K; Kawanishi G
Continuous production of tissue plasminogen activator (t-PA) by human embryonic lung diploid fibroblast, IMR-90 cells, using a ceramic bed reactor.
Cytotechnology 1991;6(1):23-31.
1991: Mawatari M; Okamura K; Matsuda T; Hamanaka R; Mizoguchi H; Higashio K; Kohno K; Kuwano M
Tumor necrosis factor and epidermal growth factor modulate migration of human microvascular endothelial cells and production of tissue-type plasminogen activator and its inhibitor.
Experimental cell research 1991;192(2):574-80.
1991: Suzuki A; Itagaki Y; Shima N; Mitsuda S; Higashio K; Kawanishi G
Role of Ca2+ in t-PA production by human embryonic lung diploid fibroblast, IMR-90 cells, stimulated by proteose peptone.
Cellular signalling 1991;3(2):99-105.
1990: Higashio K; Shima N; Goto M; Itagaki Y; Nagao M; Yasuda H; Morinaga T
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor.
Biochemical and biophysical research communications 1990;170(1):397-404.

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Kanji Higashio

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