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Kanji Higashio

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Akihiro Tomoyasu; Kanji Higashio; Kazuhiro Kanomata; Masaaki Goto; Kunihiko Kodaira; Hiroko Serizawa; Tatsuo Suda; Atsushi Nakamura; Junya Nojima; Toru Fukuda; Takenobu Katagiri
Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs.
Kunihiko Kodaira; Mana Imada; Masaaki Goto; Akihiro Tomoyasu; Toru Fukuda; Ryutaro Kamijo; Tatsuo Suda; Kanji Higashio; Takenobu Katagiri
Purification and identification of a BMP-like factor from bovine serum.
Akihiro Tomoyasu; Kanji Higashio
[Osteoclastogenesis inhibitory factor/osteoprotegerin(OCIF/OPG)].

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All Publications

2007: Akihiro Tomoyasu; Kanji Higashio; Kazuhiro Kanomata; Masaaki Goto; Kunihiko Kodaira; Hiroko Serizawa; Tatsuo Suda; Atsushi Nakamura; Junya Nojima; Toru Fukuda; Takenobu Katagiri
Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs.
Biochemical and biophysical research communications 2007;361(1):62-7.
2006: Kunihiko Kodaira; Mana Imada; Masaaki Goto; Akihiro Tomoyasu; Toru Fukuda; Ryutaro Kamijo; Tatsuo Suda; Kanji Higashio; Takenobu Katagiri
Purification and identification of a BMP-like factor from bovine serum.
Biochemical and biophysical research communications 2006;345(3):1224-31.
2004: Akihiro Tomoyasu; Kanji Higashio
[Osteoclastogenesis inhibitory factor/osteoprotegerin(OCIF/OPG)].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 2():560-5.
2003: Hirayuki Enomoto; Satoko Shiojiri; Kazuto Hoshi; Tatsuya Furuichi; Ryo Fukuyama; Carolina A Yoshida; Naoko Kanatani; Reiko Nakamura; Atsuko Mizuno; Akira Zanma; Kazuki Yano; Hisataka Yasuda; Kanji Higashio; Kenji Takada; Toshihisa Komori
Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene.
The Journal of biological chemistry 2003;278(26):23971-7.
2002: Teruhito Yamashita; Seiji Okada; Kanji Higashio; Yo-ichi Nabeshima; Masaki Noda
Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype.
Endocrinology 2002;143(12):4711-7.
2002: Tatsuo Suda; Nobuyuki Shima; Kanji Higashio
[Merger of bone biology and immunology].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(13):1837-43.
2002: Atsuko Mizuno; Takeshi Kanno; Masaki Hoshi; Osamu Shibata; Kazuki Yano; Nobuaki Fujise; Masahiko Kinosaki; Kyoji Yamaguchi; Eisuke Tsuda; Akihiko Murakami; Hisataka Yasuda; Kanji Higashio
Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis.
Journal of bone and mineral metabolism 2002;20(6):337-44.
2002: Shin-ichi Mochizuki; Nobuaki Fujise; Kanji Higashio; Eisuke Tsuda
Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats.
Journal of bone and mineral metabolism 2002;20(1):14-20.
2001: Kazuki Yano; Osamu Shibata; Atsuko Mizuno; F Kobayashi; Kanji Higashio; T Morinaga; Eisuke Tsuda
Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy.
Biochemical and biophysical research communications 2001;288(1):217-24.
2001: J M Quinn; Kanami Itoh; Nobuyuki Udagawa; K Hausler; Hisataka Yasuda; Nobuyuki Shima; Atsuko Mizuno; Kanji Higashio; Naoyuki Takahashi; Toshio Suda; TJ Martin; MT Gillespie
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1787-94.
2001: Kanami Itoh; Nobuyuki Udagawa; Takenobu Katagiri; S Iemura; N Ueno; Hisataka Yasuda; Kanji Higashio; J M Quinn; MT Gillespie; TJ Martin; Toshio Suda; Naoyuki Takahashi
Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.
Endocrinology 2001;142(8):3656-62.
2001: H Ihara; David T Denhardt; K Furuya; Tokuyuki Yamashita; Y Muguruma; Kunikazu Tsuji; Keith A Hruska; Kanji Higashio; S Enomoto; Akira Nifuji; Susan R Rittling; Mitsuhiko Noda
Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.
The Journal of biological chemistry 2001;276(16):13065-71.
2001: Kazuki Yano; N Nakagawa; Hisataka Yasuda; Eisuke Tsuda; Kanji Higashio
Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor.
Journal of bone and mineral metabolism 2001;19(6):365-72.
2000: S H Oh; Masahiro Miyazaki; H Kouchi; Y Inoue; M Sakaguchi; T Tsuji; Nobuyuki Shima; Kanji Higashio; Masayoshi Namba
Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro.
Biochemical and biophysical research communications 2000;279(2):500-4.
2000: A Shiota; Yasushi Yamashita; Nobuaki Fujise; Hiroaki Masunaga; H Yasuda; Kanji Higashio
A deleted form of human hepatocyte growth factor stimulates hepatic lipogenesis and lipoprotein synthesis in rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(5):443-52.
2000: Nobuyuki Udagawa; Naoyuki Takahashi; Hisataka Yasuda; Atsuko Mizuno; Kanami Itoh; Yutaka Ueno; Toshimasa Shinki; MT Gillespie; TJ Martin; Kanji Higashio; Toshio Suda
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function.
Endocrinology 2000;141(9):3478-84.
2000: Kazuo Kobayashi; Naoyuki Takahashi; E Jimi; Nobuyuki Udagawa; Masamichi Takami; S Kotake; N Nakagawa; Masahiko Kinosaki; Kyoji Yamaguchi; Nobuyuki Shima; Hisataka Yasuda; T Morinaga; Kanji Higashio; TJ Martin; Toshio Suda
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.
The Journal of experimental medicine 2000;191(2):275-86.
1999: Nobuyuki Udagawa; Naoyuki Takahashi; E Jimi; K Matsuzaki; T Tsurukai; Kanami Itoh; N Nakagawa; Hisataka Yasuda; M Goto; E Tsuda; Kanji Higashio; MT Gillespie; TJ Martin; Toshio Suda
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand.
Bone 1999;25(5):517-23.
1999: Hirohiko Arisawa; Yasushi Yamashita; H Ogawa; Hiroaki Masunaga; Kanji Higashio
Deleted form of hepatocyte growth factor ameliorates the mortality rate of severe thermal injury in rats.
Surgery 1999;126(5):925-32.
1999: N Nakagawa; Hisataka Yasuda; Kazuki Yano; S i Mochizuki; N Kobayashi; H Fujimoto; Nobuyuki Shima; T Morinaga; D Chikazu; H Kawaguchi; Kanji Higashio
Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells.
Biochemical and biophysical research communications 1999;265(1):158-63.
1999: N Nakagawa; Hisataka Yasuda; Kazuki Yano; S i Mochizuki; N Kobayashi; H Fujimoto; Kyoji Yamaguchi; Nobuyuki Shima; T Morinaga; Kanji Higashio
Basic fibroblast growth factor inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D(3) through suppressing the production of osteoclast differentiation factor.
Biochemical and biophysical research communications 1999;265(1):45-50.
1999: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; Masaaki Goto; S i Mochizuki; Eisuke Tsuda; T Morinaga; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda; Kanji Higashio
A novel molecular mechanism modulating osteoclast differentiation and function.
Bone 1999;25(1):109-13.
1999: Kazuki Yano; Eisuke Tsuda; Naohiro Washida; F Kobayashi; Masaaki Goto; A Harada; K Ikeda; Kanji Higashio; Y Yamada
Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(4):518-27.
1999: Kunihiko Kodaira; K Kodaira; Atsuko Mizuno; Hisataka Yasuda; Nobuyuki Shima; Akihiko Murakami; M Ueda; Kanji Higashio
Cloning and characterization of the gene encoding mouse osteoclast differentiation factor.
Gene 1999;230(1):121-7.
1999: Masahiko Kinosaki; Kyoji Yamaguchi; Yasushi Yamashita; Y Uematsu; H Aihara; Hiroaki Masunaga; T Morinaga; Kanji Higashio
A mutant of deleted variant of hepatocyte growth factor (dHGF) with alanine substitution in the N-terminal basic region has higher activity in vivo.
Biochemical and biophysical research communications 1999;254(2):363-7.
1999: Y Uematsu; Nobuaki Fujise; Kazuhiro Kohsaka; Hiroaki Masunaga; Kanji Higashio
Effective administration route for the deleted form of hepatocyte growth factor To exert its pharmacological effects.
Journal of pharmaceutical sciences 1999;88(1):131-5.
1998: N Nakagawa; Masahiko Kinosaki; Kyoji Yamaguchi; Nobuyuki Shima; Hisataka Yasuda; Kazuki Yano; T Morinaga; Kanji Higashio
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.
Biochemical and biophysical research communications 1998;253(2):395-400.
1998: Takuhiko Akatsu; Takehiko Murakami; Katsuhiro Ono; M Nishikawa; Eisuke Tsuda; S i Mochizuki; Nobuaki Fujise; Kanji Higashio; Kazuo Motoyoshi; Michiko Yamamoto; Naokazu Nagata
Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy.
Bone 1998;23(6):495-8.
1998: K Yano; E Tsuda; M Ueda; Kanji Higashio
Natural hepatocyte growth factor (HGF) from human serum and a bound form of recombinant HGF with heparan sulfate are indistinguishable in their physicochemical properties.
International journal of biological macromolecules 1998;23(3):227-35.
1998: Nobuyuki Shima; D B Stolz; Masahiro Miyazaki; EIICHI GOHDA; Kanji Higashio; G K Michalopoulos
Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor.
Journal of cellular physiology 1998;177(1):130-6.
1998: Takuhiko Akatsu; Takehiko Murakami; M Nishikawa; Katsuhiro Ono; N Shinomiya; Eisuke Tsuda; S i Mochizuki; Kyoji Yamaguchi; Masahiko Kinosaki; Kanji Higashio; Michiko Yamamoto; Kazuo Motoyoshi; Naokazu Nagata
Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the interaction of stromal cells with osteoclast.
Biochemical and biophysical research communications 1998;250(2):229-34.
1998: Michiko Yamamoto; Takehiko Murakami; M Nishikawa; Eisuke Tsuda; S i Mochizuki; Kanji Higashio; Takuhiko Akatsu; Kazuo Motoyoshi; Naokazu Nagata
Hypocalcemic effect of osteoclastogenesis inhibitory factor/osteoprotegerin in the thyroparathyroidectomized rat.
Endocrinology 1998;139(9):4012-5.
1998: Masahiko Kinosaki; Kyoji Yamaguchi; Akihiko Murakami; T Morinaga; M Ueda; Kanji Higashio
Analysis of deleted variant of hepatocyte growth factor by alanine scanning mutagenesis: identification of residues essential for its biological function and generation of mutants with enhanced mitogenic activity on rat hepatocytes.
FEBS letters 1998;434(1-2):165-70.
1998: Sumiko Nagoshi; H Yasuda; J Suda; F Yamanobe; Akihiko Ohno; Kanji Higashio; Kenji Fujiwara
Hepatocyte apoptosis and hepatic expression of transforming growth factor-beta1 mRNA during involution of hyperplastic rat liver induced by hepatocyte growth factor.
Journal of gastroenterology and hepatology 1998;13(8):786-93.
1998: Atsuko Mizuno; Akihiko Murakami; N Nakagawa; Hisataka Yasuda; Eisuke Tsuda; T Morinaga; Kanji Higashio
Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis.
Gene 1998;215(2):339-43.
1998: Atsuko Mizuno; N Amizuka; K Irie; Akihiko Murakami; Nobuaki Fujise; T Kanno; Y Sato; N Nakagawa; Hisataka Yasuda; S i Mochizuki; T Gomibuchi; Kazuki Yano; Nobuyuki Shima; Naohiro Washida; Eisuke Tsuda; T Morinaga; Kanji Higashio; H Ozawa
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Biochemical and biophysical research communications 1998;247(3):610-5.
1998: T Morinaga; N Nakagawa; H Yasuda; Eisuke Tsuda; Kanji Higashio
Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor.
European journal of biochemistry / FEBS 1998;254(3):685-91.
1998: Eisuke Tsuda; Kanji Higashio
[Osteoclastogenesis inhibitory factor (OCIF)/OPG].
Nihon rinsho. Japanese journal of clinical medicine 1998;56(6):1435-9.
1998: K Tsukii; Nobuyuki Shima; S i Mochizuki; Kyoji Yamaguchi; Masahiko Kinosaki; Kazuki Yano; Osamu Shibata; Nobuyuki Udagawa; Hisataka Yasuda; Toshio Suda; Kanji Higashio
Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone.
Biochemical and biophysical research communications 1998;246(2):337-41.
1998: K Matsuzaki; Nobuyuki Udagawa; Naoyuki Takahashi; Kyoji Yamaguchi; Hisataka Yasuda; Nobuyuki Shima; T Morinaga; Yoshiaki Toyama; Y Yabe; Kanji Higashio; Toshio Suda
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
Biochemical and biophysical research communications 1998;246(1):199-204.
1998: Masahiko Kinosaki; Kyoji Yamaguchi; Akihiko Murakami; M Ueda; T Morinaga; Kanji Higashio
Identification of heparin-binding stretches of a naturally occurring deleted variant of hepatocyte growth factor (dHGF).
Biochimica et biophysica acta 1998;1384(1):93-102.
1998: Akihiro Tomoyasu; Masaaki Goto; Nobuaki Fujise; S i Mochizuki; Hisataka Yasuda; T Morinaga; Eisuke Tsuda; Kanji Higashio
Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.
Biochemical and biophysical research communications 1998;245(2):382-7.
1998: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; S i Mochizuki; Akihiro Tomoyasu; Kazuki Yano; Masaaki Goto; Akihiko Murakami; Eisuke Tsuda; T Morinaga; Kanji Higashio; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3597-602.
1998: Yasushi Yamashita; A Shiota; Nobuaki Fujise; H Ogawa; Hiroaki Masunaga; H Yasuda; Kanji Higashio
Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(3):359-60.
1998: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; S i Mochizuki; Kazuki Yano; Nobuaki Fujise; Y Sato; Masaaki Goto; Kyoji Yamaguchi; M Kuriyama; T Kanno; Akihiko Murakami; Eisuke Tsuda; T Morinaga; Kanji Higashio
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Endocrinology 1998;139(3):1329-37.
1998: Kyoji Yamaguchi; Masahiko Kinosaki; Masaaki Goto; F Kobayashi; Eisuke Tsuda; T Morinaga; Kanji Higashio
Characterization of structural domains of human osteoclastogenesis inhibitory factor.
The Journal of biological chemistry 1998;273(9):5117-23.
1998: Hiroaki Masunaga; Nobuaki Fujise; A Shiota; H Ogawa; Y Sato; Eiichi Imai; H Yasuda; Kanji Higashio
Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries.
European journal of pharmacology 1998;342(2-3):267-79.
1997: Hiroaki Masunaga; Nobuaki Fujise; Yasushi Yamashita; A Shiota; H Yasuda; Kanji Higashio
Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis.
Liver 1997;17(4):192-7.
1997: Eisuke Tsuda; Masaaki Goto; S i Mochizuki; Kazuki Yano; F Kobayashi; T Morinaga; Kanji Higashio
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.
Biochemical and biophysical research communications 1997;234(1):137-42.
1996: H Yasuda; E Imai; A Shiota; Nobuaki Fujise; T Morinaga; Kanji Higashio
Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats.
Hepatology (Baltimore, Md.) 1996;24(3):636-42.
1996: Hiroaki Masunaga; Nobuaki Fujise; A Shiota; Yasushi Yamashita; H Yasuda; Kanji Higashio
Amelioration of disordered hepatic protein synthesis by the deleted form of hepatocyte growth factor in models of liver failure in rats.
The Journal of pharmacy and pharmacology 1996;48(8):876-9.
1994: Nobuyuki Shima; Eisuke Tsuda; Masaaki Goto; Kazuki Yano; H Hayasaka; M Ueda; Kanji Higashio
Hepatocyte growth factor and its variant with a deletion of five amino acids are distinguishable in their biological activity and tertiary structure.
Biochemical and biophysical research communications 1994;200(2):808-15.
1993: Kanji Higashio; Nobuyuki Shima
Tumor cytotoxic activity of HGF-SF.
EXS 1993;65():351-68.
1992: Nobuyuki Shima; Kanji Higashio
[Structure and biological property of fibroblast-derived tumor cytotoxic factor (F-TCF)].
Nihon rinsho. Japanese journal of clinical medicine 1992;50(8):1962-6.
1992: A Suzuki; S Mitsuda; Kanji Higashio; T Kumasaka
Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone.
Biochimica et biophysica acta 1992;1133(2):167-71.
1991: Nobuyuki Shima; M Nagao; F Ogaki; Eisuke Tsuda; A Murakami; Kanji Higashio
Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein.
Biochemical and biophysical research communications 1991;180(2):1151-8.
1991: A Suzuki; S Mitsuda; Kanji Higashio; T Kumasaka
Participation of phospholipase A2 in induction of tissue plasminogen activator (t-PA) production by human fibroblast, IMR-90 cells, stimulated by proteose peptone.
Thrombosis research 1991;64(2):191-202.
1991: A Morimoto; K Okamura; R Hamanaka; Y Sato; Nobuyuki Shima; Kanji Higashio; Michihiko Kuwano
Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture.
Biochemical and biophysical research communications 1991;179(2):1042-9.
1991: Nobuyuki Shima; Kanji Higashio; H Ogaki; K Okabe
ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases.
Gastroenterologia Japonica 1991;26(4):477-82.
1991: S Mitsuda; N Kobayashi; Y Matsuda; Y Itagaki; A Suzuki; E Kumazawa; Kanji Higashio; G Kawanishi
Enhancement of tissue plasminogen activator production from human normal fibroblast IMR-90 cells by limitation of cell growth.
Applied microbiology and biotechnology 1991;35(4):504-9.
1991: Nobuyuki Shima; Y Itagaki; M Nagao; H Yasuda; T Morinaga; Kanji Higashio
A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro.
Cell biology international reports 1991;15(5):397-408.
1991: Y Itagaki; H Yasuda; T Morinaga; S Mitsuda; Kanji Higashio
Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells.
Agricultural and biological chemistry 1991;55(5):1225-32.
1991: S Mitsuda; Y Matsuda; N Kobayashi; A Suzuki; Y Itagaki; E Kumazawa; Kanji Higashio; G Kawanishi
Continuous production of tissue plasminogen activator (t-PA) by human embryonic lung diploid fibroblast, IMR-90 cells, using a ceramic bed reactor.
Cytotechnology 1991;6(1):23-31.
1991: M Mawatari; K Okamura; T Matsuda; R Hamanaka; H Mizoguchi; Kanji Higashio; Kimitoshi Kohno; Michihiko Kuwano
Tumor necrosis factor and epidermal growth factor modulate migration of human microvascular endothelial cells and production of tissue-type plasminogen activator and its inhibitor.
Experimental cell research 1991;192(2):574-80.
1991: A Suzuki; Y Itagaki; Nobuyuki Shima; S Mitsuda; Kanji Higashio; G Kawanishi
Role of Ca2+ in t-PA production by human embryonic lung diploid fibroblast, IMR-90 cells, stimulated by proteose peptone.
Cellular signalling 1991;3(2):99-105.
1990: Kanji Higashio; Nobuyuki Shima; Masaaki Goto; Y Itagaki; M Nagao; H Yasuda; T Morinaga
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor.
Biochemical and biophysical research communications 1990;170(1):397-404.