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Renee Aspiotis

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Patrick Lacombe; Suzanna Liu; Christophe Mellon; Yeeman Ramtohul; Daniel Simard; René St-Jacques; Mélissa Arbour; Renee Aspiotis; Elizabeth Cauchon; Austin Chen; Daniel Dubé; Jean-Pierre Falgueyret; Pierre-André Fournier; Maxime A Gallant; Erich Grimm; Yongxin Han; Hélène Juteau; Gavin Chit Tsui
3,4-Diarylpiperidines as potent renin inhibitors.
Austin Chen; Yves Ducharme; Jean-Pierre Falgueyret; Sébastien Gagné; Yongxin Han; Robert Houle; Sébastien Laliberté; Guillaume Larouche; Jean-François Lévesque; Dan McKay; Renee Aspiotis; Louis-Charles Campeau; Elizabeth Cauchon; Amandine Chefson; David Percival
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.
Renee Aspiotis; Austin Chen; Elizabeth Cauchon; Daniel Dubé; Jean-Pierre Falgueyret; Sébastien Gagné; Maxime A Gallant; Erich L Grimm; Robert Houle; Hélène Juteau; Patrick Lacombe; Sébastien Laliberté; Jean-François Lévesque; Dwight MacDonald; Dan McKay; Michael Percival; Patrick Roy; Stephen M Soisson; Tom Wu
The discovery and synthesis of potent zwitterionic inhibitors of renin.

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All Publications

2012: Patrick Lacombe; Suzanna Liu; Christophe Mellon; Yeeman Ramtohul; Daniel Simard; René St-Jacques; Mélissa Arbour; Renee Aspiotis; Elizabeth Cauchon; Austin Chen; Daniel Dubé; Jean-Pierre Falgueyret; Pierre-André Fournier; Maxime A Gallant; Erich Grimm; Yongxin Han; Hélène Juteau; Gavin Chit Tsui
3,4-Diarylpiperidines as potent renin inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(5):1953-7.
2011: Austin Chen; Yves Ducharme; Jean-Pierre Falgueyret; Sébastien Gagné; Yongxin Han; Robert Houle; Sébastien Laliberté; Guillaume Larouche; Jean-François Lévesque; Dan McKay; Renee Aspiotis; Louis-Charles Campeau; Elizabeth Cauchon; Amandine Chefson; David Percival
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.
Bioorganic & medicinal chemistry letters 2011;21(24):7399-404.
2011: Renee Aspiotis; Austin Chen; Elizabeth Cauchon; Daniel Dubé; Jean-Pierre Falgueyret; Sébastien Gagné; Maxime A Gallant; Erich L Grimm; Robert Houle; Hélène Juteau; Patrick Lacombe; Sébastien Laliberté; Jean-François Lévesque; Dwight MacDonald; Dan McKay; Michael Percival; Patrick Roy; Stephen M Soisson; Tom Wu
The discovery and synthesis of potent zwitterionic inhibitors of renin.
Bioorganic & medicinal chemistry letters 2011;21(8):2430-6.
2010: Maxime A Gallant; Renee Aspiotis; Stephen Day; Rebecca Dias; Daniel Dubé; Laurence Dubé; Richard W Friesen; Mario Girard; Daniel Guay; Pierre Hamel; Zheng Huang; Patrick Lacombe; Sebastien Laliberté; Jean-François Lévesque; Susana Liu; Dwight MacDonald; Joseph Mancini; Donald W Nicholson; Angela Styhler; Karen Townson; Kerry Waters; Robert N Young; Yves Girard
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Bioorganic & medicinal chemistry letters 2010;20(22):6387-93.
2010: Renee Aspiotis; Denis Deschênes; Daniel Dubé; Yves Girard; Zheng Huang; France Laliberté; Susana Liu; Robert Papp; Donald W Nicholson; Robert N Young
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(18):5502-5.
2007: Elise Isabel; Renee Aspiotis; W Cameron Black; John Colucci; Réjean Fortin; André Giroux; Erich L Grimm; Yongxin Han; Christophe Mellon; Donald W Nicholson; Dita M Rasper; Johanne Renaud; Sophie Roy; John Tam; Paul Tawa; John P Vaillancourt; Steven Xanthoudakis; Robert Zamboni
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Bioorganic & medicinal chemistry letters 2007;17(6):1671-4.
2005: Christophe Mellon; Renee Aspiotis; Cameron W Black; Christopher I Bayly; Erich L Grimm; André Giroux; Yongxin Han; Elise Isabel; Daniel J McKay; Donald W Nicholson; Dita M Rasper; Sophie Roy; John Tam; Nancy A Thornberry; John P Vaillancourt; Steven Xanthoudakis; Robert Zamboni
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(17):3886-90.
2005: Denis Riendeau; Renee Aspiotis; Diane Ethier; Yves Gareau; Erich L Grimm; Jocelyne Guay; Sébastien Guiral; Hélène Juteau; Joseph A Mancini; Nathalie Méthot; Joel Rubin; Richard W Friesen
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Bioorganic & medicinal chemistry letters 2005;15(14):3352-5.
2004: Joseph W Becker; Jennifer Rotonda; Stephen M Soisson; Renee Aspiotis; Christopher I Bayly; Sébastien Francoeur; Michel Gallant; Marga Garcia-Calvo; André Giroux; Erich L Grimm; Yongxin Han; Dan McKay; Donald W Nicholson; Erin Peterson; Johanne Renaud; Sophie Roy; Nancy A Thornberry; Robert Zamboni
Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Journal of medicinal chemistry 2004;47(10):2466-74.
2004: Erich L Grimm; Bruno Roy; Renee Aspiotis; Christopher I Bayly; Donald W Nicholson; Dita M Rasper; Johanne Renaud; Sophie Roy; John Tam; Paul Tawa; John P Vaillancourt; Steven Xanthoudakis; Robert Zamboni
Solid phase synthesis of selective caspase-3 peptide inhibitors.
Bioorganic & medicinal chemistry 2004;12(5):845-51.
2004: Yongxin Han; André Giroux; Erich L Grimm; Renee Aspiotis; Sébastien Francoeur; Christopher I Bayly; Daniel J McKay; Sophie Roy; Steven Xanthoudakis; John P Vaillancourt; Dita M Rasper; John Tam; Paul Tawa; Nancy A Thornberry; Erin P Paterson; Margarita Garcia-Calvo; Joseph W Becker; Jennifer Rotonda; Donald W Nicholson; Robert Zamboni
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(3):805-8.
2000: Richard S Hotchkiss; Katherine C Chang; Paul E Swanson; Kevin W Tinsley; JJ Hui; P Klender; Steven Xanthoudakis; S Roy; C Black; E Grimm; Renee Aspiotis; Y Han; D W Nicholson; Irene E Karl
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.
Nature immunology 2000;1(6):496-501.