Shigeki Higashiyama

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Akino Yuichi; Teshima Teruki; Kihara Ayaka; Kodera-Suzumoto Yuko; Inaoka Miho; Higashiyama Shigeki; Furusawa Yoshiya; Matsuura Nariaki
Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells.
Uetani Teruyoshi; Nakayama Hironao; Okayama Hideki; Okura Takafumi; Higaki Jitsuo; Inoue Hirofumi; Higashiyama Shigeki
Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.
Hirata Y; Ogasawara N; Sasaki M; Mizushima T; Shimura T; Mizoshita T; Mori Y; Kubota E; Wada T; Tanida S; Kataoka H; Kamiya T; Higashiyama S; Joh T
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.

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2009: Akino Yuichi; Teshima Teruki; Kihara Ayaka; Kodera-Suzumoto Yuko; Inaoka Miho; Higashiyama Shigeki; Furusawa Yoshiya; Matsuura Nariaki
Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells.
International journal of radiation oncology, biology, physics 2009;75(2):475-81.
2009: Uetani Teruyoshi; Nakayama Hironao; Okayama Hideki; Okura Takafumi; Higaki Jitsuo; Inoue Hirofumi; Higashiyama Shigeki
Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.
The Journal of biological chemistry 2009;284(18):12399-409.
2009: Hirata Y; Ogasawara N; Sasaki M; Mizushima T; Shimura T; Mizoshita T; Mori Y; Kubota E; Wada T; Tanida S; Kataoka H; Kamiya T; Higashiyama S; Joh T
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.
British journal of cancer 2009;100(8):1320-9.
2008: Isokane Mayumi; Hieda Miki; Hirakawa Satoshi; Shudou Masachika; Nakashiro Koichi; Hashimoto Koji; Hamakawa Hiroyuki; Higashiyama Shigeki
Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.
Journal of cell science 2008;121(Pt 21):3608-18.
2008: Murayama Yoko; Shinomura Yasuhisa; Oritani Kenji; Miyagawa Jun-Ichiro; Yoshida Hitoshi; Nishida Makoto; Katsube Fumie; Shiraga Masamichi; Miyazaki Tamana; Nakamoto Taisei; Tsutsui Shusaku; Tamura Shinji; Higashiyama Shigeki; Shimomura Iichirou; Hayashi Norio
The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells.
Journal of cellular physiology 2008;216(1):135-43.
2008: Hieda Miki; Isokane Mayumi; Koizumi Michiko; Higashi Chiduru; Tachibana Taro; Shudou Masachika; Taguchi Tomohiko; Hieda Yohki; Higashiyama Shigeki
Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.
The Journal of cell biology 2008;180(4):763-9.
2008: Higashiyama Shigeki; Iwabuki Hidehiko; Morimoto Chie; Hieda Miki; Inoue Hirofumi; Matsushita Natsuki
Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.
Cancer science 2008;99(2):214-20.
2008: Nanba Daisuke; Inoue Hirofumi; Shigemi Yuka; Shirakata Yuji; Hashimoto Koji; Higashiyama Shigeki
An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.
Journal of cellular physiology 2008;214(2):465-73.
2007: Shiraishi Atsushi; Joko Takeshi; Higashiyama Shigeki; Ohashi Yuichi
Role of promyelocytic leukemia zinc finger protein in proliferation of cultured human corneal endothelial cells.
Cornea 2007;26(9 Suppl 1):S55-8.
2007: Kinugasa Yumi; Hieda Miki; Hori Masatsugu; Higashiyama Shigeki
The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.
The Journal of biological chemistry 2007;282(20):14797-806.
2007: Shiraishi K; Yamasaki K; Nanba D; Inoue H; Hanakawa Y; Shirakata Y; Hashimoto K; Higashiyama S
Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.
Oncogene 2007;26(3):339-48.
2007: Morita Shin-ichi; Shirakata Yuji; Shiraishi Atsushi; Kadota Yuko; Hashimoto Koji; Higashiyama Shigeki; Ohashi Yuichi
Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members.
Molecular vision 2007;13():2119-28.
2007: Joko Takeshi; Nanba Daisuke; Shiba Fumio; Miyata Kazunori; Shiraishi Atsushi; Ohashi Yuichi; Higashiyama Shigeki
Effects of promyelocytic leukemia zinc finger protein on the proliferation of cultured human corneal endothelial cells.
Molecular vision 2007;13():649-58.
2006: Nanba Daisuke; Kinugasa Yumi; Morimoto Chie; Koizumi Michiko; Yamamura Hisako; Takahashi Katsuhito; Takakura Nobuyuki; Mekada Eisuke; Hashimoto Koji; Higashiyama Shigeki
Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.
Biochemical and biophysical research communications 2006;350(2):315-21.
2006: Watari A; Takaki K; Higashiyama S; Li Y; Satomi Y; Takao T; Tanemura A; Yamaguchi Y; Katayama I; Shimakage M; Miyashiro I; Takami K; Kodama K; Yutsudo M
Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.
Oncogene 2006;25(56):7373-80.
2006: Shimakage Misuzu; Inoue Nobumasa; Ohshima Kohichi; Kawahara Kunimitsu; Oka Takashi; Yasui Kazuta; Matsumoto Kayoko; Inoue Hirokazu; Watari Akihiro; Higashiyama Shinji; Yutsudo Masuo
Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma.
International journal of cancer. Journal international du cancer 2006;119(7):1648-53.
2006: Kikugawa Tadahiko; Kinugasa Yumi; Shiraishi Ken; Nanba Daisuke; Nakashiro Koh-ichi; Tanji Nozomu; Yokoyama Masayoshi; Higashiyama Shigeki
PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.
The Prostate 2006;66(10):1092-9.
2006: Hirao Takafumi; Nanba Daisuke; Tanaka Motonari; Ishiguro Hiroshi; Kinugasa Yumi; Doki Yuichiro; Yano Masahiko; Matsuura Nariaki; Monden Morito; Higashiyama Shigeki
Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells.
Experimental cell research 2006;312(3):331-9.
2005: Fukui Kenji; Yang Qin; Cao Yang; Takahashi Noriko; Hatakeyama Hiroyasu; Wang Haiyan; Wada Jun; Zhang Yanling; Marselli Lorella; Nammo Takao; Yoneda Kazue; Onishi Mineki; Higashiyama Shigeki; Matsuzawa Yuji; Gonzalez Frank J; Weir Gordon C; Kasai Haruo; Shimomura Iichiro; Miyagawa Jun-ichiro; Wollheim Claes B; Yamagata Kazuya
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
Cell metabolism 2005;2(6):373-84.
2005: Joh Takashi; Kataoka Hiromi; Tanida Satoshi; Watanabe Katsushi; Ohshima Tadayuki; Sasaki Makoto; Nakao Haruhisa; Ohhara Hirotaka; Higashiyama Shigeki; Itoh Makoto
Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.
Digestive diseases and sciences 2005;50(11):2081-9.
2005: Tokumaru Sho; Sayama Koji; Shirakata Yuji; Komatsuzawa Hitoshi; Ouhara Kazuhisa; Hanakawa Yasushi; Yahata Yoko; Dai Xiuju; Tohyama Mikiko; Nagai Hiroshi; Yang Lujun; Higashiyama Shigeki; Yoshimura Akihiko; Sugai Motoyuki; Hashimoto Koji
Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4662-8.
2005: Morimoto Chie; Higashiyama Shigeki
[Heparin-binding EGF-like growth factor (HB-EGF)]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():110-2.
2005: Morimoto Chie; Higashiyama Shigeki
[Epidermal growth factor (EGF)]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():107-9.
2005: Higashiyama Shigeki; Nanba Daisuke
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Biochimica et biophysica acta 2005;1751(1):110-7.
2005: Takeda Masashi; Yamamoto Marii; Isoda Katsuhiro; Higashiyama Shinji; Hirose Motohiro; Ohgushi Hajime; Kawase Masaya; Yagi Kiyohito
Availability of bone marrow stromal cells in three-dimensional coculture with hepatocytes and transplantation into liver-damaged mice.
Journal of bioscience and bioengineering 2005;100(1):77-81.
2005: Kozawa Junji; Tokui Yae; Moriwaki Makoto; Li Ming; Ohmoto Hiroshi; Yuan Ming; Zhang Jun; Iwahashi Hiromi; Imagawa Akihisa; Yamagata Kazuya; Tochino Yoshihiro; Shimomura Iichiro; Higashiyama Shigeki; Miyagawa Jun-ichiro
Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.
Pancreas 2005;31(1):32-42.
2005: Shirakata Yuji; Kimura Rina; Nanba Daisuke; Iwamoto Ryo; Tokumaru Sho; Morimoto Chie; Yokota Koichi; Nakamura Masanori; Sayama Koji; Mekada Eisuke; Higashiyama Shigeki; Hashimoto Koji
Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.
Journal of cell science 2005;118(Pt 11):2363-70.
2005: Isoda Katsuhiro; Koide Hiroko; Kojima Midori; Arita Eri; Ikkaku Masahiro; Higashiyama Shinji; Tashiro Fumi; Yamato Eiji; Miyazaki Jun-Ichi; Kawase Masaya; Yagi Kiyohito
Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene.
Biochemical and biophysical research communications 2005;329(1):182-7.
2005: Itoh Yusuke; Joh Takashi; Tanida Satoshi; Sasaki Makoto; Kataoka Hiromi; Itoh Keisuke; Oshima Tadayuki; Ogasawara Naotaka; Togawa Shouzo; Wada Tsuneya; Kubota Hidetsugu; Mori Yoshinori; Ohara Hirotaka; Nomura Tomoyuki; Higashiyama Shigeki; Itoh Makoto
IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells.
Cytokine 2005;29(6):275-82.
2005: Toki Fujio; Nanba Daisuke; Matsuura Nariaki; Higashiyama Shigeki
Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in the cell cycle.
Journal of cellular physiology 2005;202(3):839-48.
2004: Higashiyama Shigeki
Metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor and its pathophysiological roles.
Protein and peptide letters 2004;11(5):443-50.
2004: Tanaka Motonari; Nanba Daisuke; Mori Seiji; Shiba Fumio; Ishiguro Hiroshi; Yoshino Koichiro; Matsuura Nariaki; Higashiyama Shigeki
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands.
The Journal of biological chemistry 2004;279(40):41950-9.
2004: Kinugasa Yumi; Ishiguro Hiroshi; Tokita Yoshihito; Oohira Atsuhiko; Ohmoto Hiroshi; Higashiyama Shigeki
Neuroglycan C, a novel member of the neuregulin family.
Biochemical and biophysical research communications 2004;321(4):1045-9.
2004: Tanida Satoshi; Joh Takashi; Itoh Keisuke; Kataoka Hiromi; Sasaki Makoto; Ohara Hirotaka; Nakazawa Takahiro; Nomura Tomoyuki; Kinugasa Yumi; Ohmoto Hiroshi; Ishiguro Hiroshi; Yoshino Kohichiro; Higashiyama Shigeki; Itoh Makoto
The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells.
Gastroenterology 2004;127(2):559-69.
2004: Murayama Yoko; Miyagawa Jun-ichiro; Oritani Kenji; Yoshida Hitoshi; Yamamoto Katsumi; Kishida Osamu; Miyazaki Tamana; Tsutsui Shusaku; Kiyohara Tatsuya; Miyazaki Yoshiji; Higashiyama Shigeki; Matsuzawa Yuji; Shinomura Yasuhisa
CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.
Journal of cell science 2004;117(Pt 15):3379-88.
2004: Nanba Daisuke; Toki Fujio; Higashiyama Shigeki
Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF.
Biochemical and biophysical research communications 2004;320(2):376-82.
2004: Shintani Yasushi; Higashiyama Shigeki; Ohta Mitsunori; Hirabayashi Hirohisa; Yamamoto Sakae; Yoshimasu Tatsuya; Matsuda Hikaru; Matsuura Nariaki
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis.
Cancer research 2004;64(12):4190-6.
2004: Nanba Daisuke; Higashiyama Shigeki
Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor.
Cytokine & growth factor reviews 2004;15(1):13-9.
2004: Isoda Katsuhiro; Kojima Midori; Takeda Masashi; Higashiyama Shinji; Kawase Masaya; Yagi Kiyohito
Maintenance of hepatocyte functions by coculture with bone marrow stromal cells.
Journal of bioscience and bioengineering 2004;97(5):343-6.
2003: Yamazaki Satoru; Iwamoto Ryo; Saeki Kazuko; Asakura Masanori; Takashima Seiji; Yamazaki Ayano; Kimura Rina; Mizushima Hiroto; Moribe Hiroki; Higashiyama Shigeki; Endoh Masayuki; Kaneda Yasufumi; Takagi Satoshi; Itami Satoshi; Takeda Naoki; Yamada Gen; Mekada Eisuke
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.
The Journal of cell biology 2003;163(3):469-75.
2003: Nanba Daisuke; Mammoto Akiko; Hashimoto Koji; Higashiyama Shigeki
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF.
The Journal of cell biology 2003;163(3):489-502.
2003: Madarame Jun; Higashiyama Shigeki; Kiyota Hiroshi; Madachi Ayako; Toki Fujio; Shimomura Tatsuya; Tani Naoyuki; Oishi Yukihiko; Matsuura Nariaki
Transactivation of epidermal growth factor receptor after heparin-binding epidermal growth factor-like growth factor shedding in the migration of prostate cancer cells promoted by bombesin.
The Prostate 2003;57(3):187-95.
2003: Mori Seiji; Tanaka Motonari; Nanba Daisuke; Nishiwaki Eiji; Ishiguro Hiroshi; Higashiyama Shigeki; Matsuura Nariaki
PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.
The Journal of biological chemistry 2003;278(46):46029-34.
2003: Tsutsui Toshio; Koide Hiroko; Fukahori Hiroko; Isoda Katsuhiro; Higashiyama Shinji; Maeda Isamu; Tashiro Fumi; Yamato Eiji; Miyazaki Jun-Ichi; Yodoi Junji; Kawase Masaya; Yagi Kiyohito
Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis.
Biochemical and biophysical research communications 2003;307(4):765-70.
2003: Higashiyama Shigeki
[Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy]
Nippon rinsho. Japanese journal of clinical medicine 2003;61(5):767-75.
2003: Iwamoto Ryo; Yamazaki Satoru; Asakura Masanori; Takashima Seiji; Hasuwa Hidetoshi; Miyado Kenji; Adachi Satoshi; Kitakaze Masafumi; Hashimoto Koji; Raab Gerhard; Nanba Daisuke; Higashiyama Shigeki; Hori Masatsugu; Klagsbrun Michael; Mekada Eisuke
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3221-6.
2003: Kiso Shinichi; Kawata Sumio; Tamura Shinji; Inui Yoshiaki; Yoshida Yuichi; Sawai Yoshiyuki; Umeki Shinobu; Ito Nobuyuki; Yamada Akira; Miyagawa Jun-Ichiro; Higashiyama Shigeki; Iwawaki Takao; Saito Michiko; Taniguchi Naoyuki; Matsuzawa Yuji; Kohno Kenji
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy.
Gastroenterology 2003;124(3):701-7.
2003: Higashiyama S; Noda M; Kawase M; Yagi K
Mixed-ligand modification of polyamidoamine dendrimers to develop an effective scaffold for maintenance of hepatocyte spheroids.
Journal of biomedical materials research. Part A 2003;64(3):475-82.
2003: Higashiyama Shinji; Noda Megumi; Muraoka Satoko; Hirose Motohiro; Ohgushi Hajime; Kawase Masaya; Yagi Kiyohito
Transplantation of hepatocytes cultured on hydroxyapatite into Nagase analbuminemia rats.
Journal of bioscience and bioengineering 2003;96(1):83-5.
2002: Komori Masato; Tsuji Shingo; Sun Wei-Hao; Tsujii Masahiko; Kawai Naoki; Yasumaru Masakazu; Kakiuchi Yoshimi; Kimura Arata; Sasaki Yutaka; Higashiyama Shigeki; Kawano Sunao; Hori Masatsugu
Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(6):G1368-78.
2002: Sakuda Shigeru; Tamura Shinji; Yamada Akira; Miyagawa Jun-Ichiro; Yamamoto Koji; Kiso Shinichi; Ito Nobuyuki; Higashiyama Shigeki; Taniguchi Naoyuki; Kawata Sumio; Matsuzawa Yuji
NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor.
Journal of hepatology 2002;36(4):527-33.
2002: Murayama Yoko; Miyagawa Jun-ichiro; Shinomura Yasuhisa; Kanayama Shuji; Isozaki Koji; Yamamori Katsumi; Mizuno Hitoshi; Ishiguro Shingo; Kiyohara Tatsuya; Miyazaki Yoshiji; Taniguchi Naoyuki; Higashiyama Shigeki; Matsuzawa Yuji
Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.
International journal of cancer. Journal international du cancer 2002;98(4):505-13.
2002: Asakura Masanori; Kitakaze Masafumi; Takashima Seiji; Liao Yulin; Ishikura Fuminobu; Yoshinaka Tsuyoshi; Ohmoto Hiroshi; Node Koichi; Yoshino Kohichiro; Ishiguro Hiroshi; Asanuma Hiroshi; Sanada Shoji; Matsumura Yasushi; Takeda Hiroshi; Beppu Shintaro; Tada Michihiko; Hori Masatsugu; Higashiyama Shigeki
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy.
Nature medicine 2002;8(1):35-40.
2001: Koh Y H; Che W; Higashiyama S; Takahashi M; Miyamoto Y; Suzuki K; Taniguchi N
Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells.
Journal of biochemistry 2001;130(3):351-8.
2001: Umeda Y; Miyazaki Y; Shiinoki H; Higashiyama S; Nakanishi Y; Hieda Y
Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland.
Developmental biology 2001;237(1):202-11.
2001: Koh Y H; Suzuki K; Che W; Park Y S; Miyamoto Y; Higashiyama S; Taniguchi N
Inactivation of glutathione peroxidase by NO leads to the accumulation of H2O2 and the induction of HB-EGF via c-Jun NH2-terminal kinase in rat aortic smooth muscle cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1472-4.
2001: Kawase M; Shiomi T; Matsui H; Ouji Y; Higashiyama S; Tsutsui T; Yagi K
Suppression of apoptosis in hepatocytes by fructose-modified dendrimers.
Journal of biomedical materials research 2001;54(4):519-24.
2001: Kitada T; Miyoshi E; Noda K; Higashiyama S; Ihara H; Matsuura N; Hayashi N; Kawata S; Matsuzawa Y; Taniguchi N
The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin.
The Journal of biological chemistry 2001;276(1):475-80.
2000: Tokumaru S; Higashiyama S; Endo T; Nakagawa T; Miyagawa J I; Yamamori K; Hanakawa Y; Ohmoto H; Yoshino K; Shirakata Y; Matsuzawa Y; Hashimoto K; Taniguchi N
Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing.
The Journal of cell biology 2000;151(2):209-20.
2000: Nishida M; Miyagawa J; Yamashita S; Higashiyama S; Nakata A; Ouchi N; Tamura R; Yamamori K; Kihara S; Taniguchi N; Matsuzawa Y
Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(5):1236-43.
2000: Nakano N; Higashiyama S; Kajihara K; Endo T; Ishiguro H; Yamada K; Nagatsu T; Taniguchi N
NTAKalpha and beta isoforms stimulate breast tumor cell growth by means of different receptor combinations.
Journal of biochemistry 2000;127(5):925-30.
1999: Kiso S; Kawata S; Tamura S; Miyagawa J; Ito N; Tsushima H; Yamada A; Umeki S; Higashiyama S; Taniguchi N; Matsuzawa Y
Expression of heparin-binding epidermal growth factor-like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis.
Journal of gastroenterology and hepatology 1999;14(12):1203-9.
1999: Kiso S; Kawata S; Tamura S; Umeki S; Ito N; Tsushima H; Yamada A; Miyagawa J; Higashiyama S; Taniguchi N; Matsuzawa Y
Effects of exogenous human heparin-binding epidermal growth factor-like growth factor on DNA synthesis of hepatocytes in normal mouse liver.
Biochemical and biophysical research communications 1999;259(3):683-7.
1999: Kayanoki Y; Higashiyama S; Suzuki K; Asahi M; Kawata S; Matsuzawa Y; Taniguchi N
The requirement of both intracellular reactive oxygen species and intracellular calcium elevation for the induction of heparin-binding EGF-like growth factor in vascular endothelial cells and smooth muscle cells.
Biochemical and biophysical research communications 1999;259(1):50-5.
1999: Yoshiuchi I; Yamagata K; Yang Q; Iwahashi H; Okita K; Yamamoto K; Oue T; Imagawa A; Hamaguchi T; Yamasaki T; Horikawa Y; Satoh T; Nakajima H; Miyazaki J; Higashiyama S; Miyagawa J; Namba M; Hanafusa T; Matsuzawa Y
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.
Diabetologia 1999;42(5):621-6.
1999: Nakano N; Higashiyama S; Takashima S; Tsuruoka N; Klagsbrun M; Taniguchi N
Purification and characterization of a novel vascular endothelial cell growth inhibitor secreted by macrophage-like U-937 cells.
Journal of biochemistry 1999;125(2):368-74.
1999: Miyazaki Y; Shinomura Y; Tsutsui S; Zushi S; Higashimoto Y; Kanayama S; Higashiyama S; Taniguchi N; Matsuzawa Y
Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor.
Gastroenterology 1999;116(1):78-89.
1998: Yamada A; Kawata S; Tamura S; Kiso S; Higashiyama S; Umeshita K; Sakon M; Taniguchi N; Monden M; Matsuzawa Y
Plasma heparin-binding EGF-like growth factor levels in patients after partial hepatectomy as determined with an enzyme-linked immunosorbent assay.
Biochemical and biophysical research communications 1998;246(3):783-7.
1997: Yagi K; Michibayashi N; Kurikawa N; Nakashima Y; Mizoguchi T; Harada A; Higashiyama S; Muranaka H; Kawase M
Effectiveness of fructose-modified chitosan as a scaffold for hepatocyte attachment.
Biological & pharmaceutical bulletin 1997;20(12):1290-4.
1997: Kaneto H; Miyagawa J; Kajimoto Y; Yamamoto K; Watada H; Umayahara Y; Hanafusa T; Matsuzawa Y; Yamasaki Y; Higashiyama S; Taniguchi N
Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation.
The Journal of biological chemistry 1997;272(46):29137-43.
1997: Fukuda K; Kawata S; Inui Y; Higashiyama S; Matsuda Y; Igura T; Tamura S; Taniguchi N; Matsuzawa Y
High concentration of glucose increases mitogenic responsiveness to heparin-binding epidermal growth factor-like growth factor in rat vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):1962-8.
1997: Higashiyama S; Horikawa M; Yamada K; Ichino N; Nakano N; Nakagawa T; Miyagawa J; Matsushita N; Nagatsu T; Taniguchi N; Ishiguro H
A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.
Journal of biochemistry 1997;122(3):675-80.
1997: Kayanoki Y; Che W; Kawata S; Matsuzawa Y; Higashiyama S; Taniguchi N
The effect of cilostazol, a cyclic nucleotide phosphodiesterase III inhibitor, on heparin-binding EGF-like growth factor expression in macrophages and vascular smooth muscle cells.
Biochemical and biophysical research communications 1997;238(2):478-81.
1997: Sakuma T; Higashiyama S; Hosoe S; Hayashi S; Taniguchi N
CD9 antigen interacts with heparin-binding EGF-like growth factor through its heparin-binding domain.
Journal of biochemistry 1997;122(2):474-80.
1997: Che W; Asahi M; Takahashi M; Kaneto H; Okado A; Higashiyama S; Taniguchi N
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes.
The Journal of biological chemistry 1997;272(29):18453-9.
1997: Tsutsui S; Shinomura Y; Higashiyama S; Higashimoto Y; Miyazaki Y; Kanayama S; Hiraoka S; Minami T; Kitamura S; Murayama Y; Miyagawa J; Taniguchi N; Matsuzawa Y
Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach.
Biochemical and biophysical research communications 1997;235(3):520-3.
1997: Inui S; Higashiyama S; Hashimoto K; Higashiyama M; Yoshikawa K; Taniguchi N
Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth.
Journal of cellular physiology 1997;171(3):291-8.
1997: Miyoshi E; Higashiyama S; Nakagawa T; Hayashi N; Taniguchi N
Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line.
The Journal of biological chemistry 1997;272(22):14349-55.
1996: Igura T; Kawata S; Miyagawa J; Inui Y; Tamura S; Fukuda K; Isozaki K; Yamamori K; Taniguchi N; Higashiyama S; Matsuzawa Y
Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(12):1524-31.
1996: Nakata A; Miyagawa J; Yamashita S; Nishida M; Tamura R; Yamamori K; Nakamura T; Nozaki S; Kameda-Takemura K; Kawata S; Taniguchi N; Higashiyama S; Matsuzawa Y
Localization of heparin-binding epidermal growth factor-like growth factor in human coronary arteries. Possible roles of HB-EGF in the formation of coronary atherosclerosis.
Circulation 1996;94(11):2778-86.
1996: Nakagawa T; Higashiyama S; Mitamura T; Mekada E; Taniguchi N
Amino-terminal processing of cell surface heparin-binding epidermal growth factor-like growth factor up-regulates its juxtacrine but not its paracrine growth factor activity.
The Journal of biological chemistry 1996;271(48):30858-63.
1996: Asakawa H; Miyagawa J; Higashiyama S; Goishi K; Hanafusa T; Kuwajima M; Taniguchi N; Matsuzawa Y
High glucose and hyperosmolarity increase heparin-binding epidermal growth factor-like growth factor (HB-EGF) production in cultured human aortic endothelial cells.
Cell biochemistry and function 1996;14(3):181-6.
1996: Miyazaki Y; Shinomura Y; Tsutsui S; Yasunaga Y; Zushi S; Higashiyama S; Taniguchi N; Matsuzawa Y
Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells.
Biochemical and biophysical research communications 1996;226(2):542-6.
1996: Taniguchi N; Kaneto H; Asahi M; Takahashi M; Wenyi C; Higashiyama S; Fujii J; Suzuki K; Kayanoki Y
Involvement of glycation and oxidative stress in diabetic macroangiopathy.
Diabetes 1996;45 Suppl 3():S81-3.
1996: Miyazaki Y; Shinomura Y; Higashiyama S; Kanayama S; Higashimoto Y; Tsutsui S; Zushi S; Taniguchi N; Matsuzawa Y
Heparin-binding EGF-like growth factor is an autocrine growth factor for rat gastric epithelial cells.
Biochemical and biophysical research communications 1996;223(1):36-41.
1996: Kiso S; Kawata S; Tamura S; Ito N; Tsushima H; Yamada A; Higashiyama S; Taniguchi N; Matsuzawa Y
Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine.
Biochemical and biophysical research communications 1996;220(2):285-8.
1996: Ito N; Higashiyama S; Kawata S; Tamura S; Kiso S; Tsushima H; Nakagawa T; Matsuzawa Y; Taniguchi N
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Biochimica et biophysica acta 1996;1310(1):163-7.
1995: Shishido Y; Sharma K D; Higashiyama S; Klagsbrun M; Mekada E
Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding epidermal growth factor-like growth factor.
The Journal of biological chemistry 1995;270(49):29578-85.
1995: Islam K N; Takahashi M; Higashiyama S; Myint T; Uozumi N
Fragmentation of ceruloplasmin following non-enzymatic glycation reaction.
Journal of biochemistry 1995;118(5):1054-60.
1995: Kiso S; Kawata S; Tamura S; Higashiyama S; Ito N; Tsushima H; Taniguchi N; Matsuzawa Y
Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy.
Hepatology (Baltimore, Md.) 1995;22(5):1584-90.
1995: Fukuda K; Inui Y; Kawata S; Higashiyama S; Matsuda Y; Maeda Y; Igura T; Yoshida S; Taniguchi N; Matsuzawa Y
Increased mitogenic response to heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells of diabetic rats.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1680-7.
1995: Murayama Y; Miyagawa J; Higashiyama S; Kondo S; Yabu M; Isozaki K; Kayanoki Y; Kanayama S; Shinomura Y; Taniguchi N
Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa.
Gastroenterology 1995;109(4):1051-9.
1995: Goishi K; Higashiyama S; Klagsbrun M; Nakano N; Umata T; Ishikawa M; Mekada E; Taniguchi N
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Molecular biology of the cell 1995;6(8):967-80.
1995: Higashiyama S; Iwamoto R; Goishi K; Raab G; Taniguchi N; Klagsbrun M; Mekada E
The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.
The Journal of cell biology 1995;128(5):929-38.
1995: Mitamura T; Higashiyama S; Taniguchi N; Klagsbrun M; Mekada E
Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.
The Journal of biological chemistry 1995;270(3):1015-9.
1994: Inui Y; Higashiyama S; Kawata S; Tamura S; Miyagawa J; Taniguchi N; Matsuzawa Y
Expression of heparin-binding epidermal growth factor in human hepatocellular carcinoma.
Gastroenterology 1994;107(6):1799-804.
1994: Hashimoto K; Higashiyama S; Asada H; Hashimura E; Kobayashi T; Sudo K; Nakagawa T; Damm D; Yoshikawa K; Taniguchi N
Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.
The Journal of biological chemistry 1994;269(31):20060-6.
1994: Iwamoto R; Higashiyama S; Mitamura T; Taniguchi N; Klagsbrun M; Mekada E
Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.
The EMBO journal 1994;13(10):2322-30.
1994: Ito N; Kawata S; Tamura S; Kiso S; Tsushima H; Damm D; Abraham J A; Higashiyama S; Taniguchi N; Matsuzawa Y
Heparin-binding EGF-like growth factor is a potent mitogen for rat hepatocytes.
Biochemical and biophysical research communications 1994;198(1):25-31.
1993: Higashiyama S; Abraham J A; Klagsbrun M
Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate.
The Journal of cell biology 1993;122(4):933-40.

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