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Linda Higgins

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Anatomy

Disorders

Multiple Myeloma

Physiology

Procedures

Xenograft Model Antitumor Assays

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Publications

TOP 3
Satyanarayana Medicherla; Fabiola Movius; Mamtha Reddy; Irina Esikova; Linda S Higgins; Irene Kerr; Jing Ying Ma; Protter Andrew
Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig.
Alison Williams; Razao Issa; Andrew Durham; Sum-Yee Leung; Ann Kapoun; Satyanarayana Medicherla; Linda S Higgins; Ian M Adcock; Kian Fan Chung
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.
Li Zhou; Aaron N Nguyen; Davendra Sohal; Jing Ying Ma; Perry Pahanish; Krishna Gundabolu; Josh Hayman; Adam Chubak; Yongkai Mo; Tushar D Bhagat; Bhaskar Das; Ann M Kapoun; Tony A Navas; Simrit Parmar; Suman Kambhampati; Andrea Pellagatti; Ira Braunchweig; Ying Zhang; Amittha Wickrema; Satyanarayana Medicherla; Jacqueline Boultwood; Leonidas C Platanias; Linda S Higgins; Alan F List; Markus Bitzer; Amit Verma
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.

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All Publications

2010: Satyanarayana Medicherla; Fabiola Movius; Mamtha Reddy; Irina Esikova; Linda S Higgins; Irene Kerr; Jing Ying Ma; Protter Andrew
Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig.
Journal of inflammation research 2010;3():9-16.
2008: Alison Williams; Razao Issa; Andrew Durham; Sum-Yee Leung; Ann Kapoun; Satyanarayana Medicherla; Linda S Higgins; Ian M Adcock; Kian Fan Chung
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.
European journal of pharmacology 2008;600(1-3):117-22.
2008: Li Zhou; Aaron N Nguyen; Davendra Sohal; Jing Ying Ma; Perry Pahanish; Krishna Gundabolu; Josh Hayman; Adam Chubak; Yongkai Mo; Tushar D Bhagat; Bhaskar Das; Ann M Kapoun; Tony A Navas; Simrit Parmar; Suman Kambhampati; Andrea Pellagatti; Ira Braunchweig; Ying Zhang; Amittha Wickrema; Satyanarayana Medicherla; Jacqueline Boultwood; Leonidas C Platanias; Linda S Higgins; Alan F List; Markus Bitzer; Amit Verma
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
Blood 2008;112(8):3434-43.
2008: Satyanarayana Medicherla; Mary F Fitzgerald; Dianne Spicer; Paul Woodman; Jing Ying Ma; Ann M Kapoun; Sarvajit Chakravarty; Sundeep Dugar; Protter Andrew; Linda S Higgins
p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.
The Journal of pharmacology and experimental therapeutics 2008;324(3):921-9.
2007: Satyanarayana Medicherla; Lingyun Li; Jing Ying Ma; Ann M Kapoun; Nicholas J Gaspar; Yu-Wang Liu; Ruban Mangadu; Gilbert O'Young; Protter Andrew; George F Schreiner; Darren H Wong; Linda S Higgins
Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.
Anticancer research 2007;27(6B):4149-57.
2007: Jill E Rogers; Fei Li; Derek D Coatney; Jodie Otremba; Jaclynn M Kriegl; T Andrew A Protter; Linda S Higgins; Satyanarayana Medicherla; Keith Lough Kirkwood
A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.
Journal of periodontology 2007;78(10):1992-8.
2007: Thomas-Toan Tran; Martin Uhl; Jing Ying Ma; Lisa Janssen; Venkataraman Sriram; Steffen Aulwurm; Irene Kerr; Andrew Lam; Heather K Webb; Ann M Kapoun; Darin E Kizer; Glenn McEnroe; Barry Hart; Jonathan Axon; Alison Murphy; Sarvajit Chakravarty; Sundeep Dugar; Protter Andrew; Linda S Higgins; Wolfgang Wick; Michael Weller; Darren H Wong
Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model.
Neuro-oncology 2007;9(3):259-70.
2007: Nicholas J Gaspar; Lingyun Li; Ann M Kapoun; Satyanarayana Medicherla; Mamatha Reddy; Georgia Li; Gilbert O'Young; Diana Quon; Margaret Henson; Debby Damm; Gladys T Muiru; Alison Murphy; Linda S Higgins; Sarvajit Chakravarty; Darren H Wong
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
Molecular pharmacology 2007;72(1):152-61.
2007: Karin Vanderkerken; Satyanarayana Medicherla; Les Coulton; Hendrik De Raeve; Angelo Willems; Michelle Lawson; Ben Van Camp; Protter Andrew; Linda S Higgins; Eline Menu; Peter I Croucher
Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma.
Cancer research 2007;67(10):4572-7.
2007: Keith Lough Kirkwood; Fei Li; Jill E Rogers; Jodie Otremba; Derek D Coatney; Jaclynn M Kreider; Nisha J D'Silva; Sarvajit Chakravarty; Sundeep Dugar; Linda S Higgins; Protter Andrew; Satyanarayana Medicherla
A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss.
The Journal of pharmacology and experimental therapeutics 2007;320(1):56-63.
2006: Tony A Navas; Mani Mohindru; Myka Estes; Jing Ying Ma; Lubomir Sokol; Perry Pahanish; Simrit Parmar; Edwin Haghnazari; Li Zhou; Robert Collins; Irene Kerr; Aaron N Nguyen; Yin Xu; Leonidas C Platanias; Alan A List; Linda S Higgins; Amit Verma
Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors.
Blood 2006;108(13):4170-7.
2006: Theresa A Guise; Khalid S Mohammad; Gregory A Clines; Elizabeth G Stebbins; Darren H Wong; Linda S Higgins; Robert L Vessella; Eva Corey; Susan Padalecki; Larry J Suva; John M Chirgwin
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 2):6213s-6216s.
2006: Susan J Smith; Peter S Fenwick; Andrew G Nicholson; F Kirschenbaum; T K Finney-Hayward; Linda S Higgins; Mark A Giembycz; Peter J Barnes; Louise E Donnelly
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages.
British journal of pharmacology 2006;149(4):393-404.
2006: Puneeta Nath; Sum-Yee Leung; Alison Williams; Alistair Noble; Sarvajit Chakravarty; Gregory R Luedtke; Satyanarayana Medicherla; Linda S Higgins; Protter Andrew; K Fan Chung
Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness.
European journal of pharmacology 2006;544(1-3):160-7.
2006: Ann M Kapoun; Nicholas J Gaspar; Ying Wang; Debby Damm; Yu-Wang Liu; Gilbert O'Young; Diana Quon; Andrew Lam; Kimberly Munson; Thomas-Toan Tran; Jing Ying Ma; Alison Murphy; Sundeep Dugar; Sarvajit Chakravarty; Protter Andrew; Fu-Qiang Wen; Xiangde Liu; Stephen I Rennard; Linda S Higgins
Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.
Molecular pharmacology 2006;70(2):518-31.
2006: Aaron N Nguyen; Elizabeth G Stebbins; Margaret Henson; Gilbert O'Young; Sun J Choi; Diana Quon; Debby Damm; Mamatha Reddy; Jing Y Ma; Edwin Haghnazari; Ann M Kapoun; Satyanarayana Medicherla; Protter Andrew; George F Schreiner; Noriyoshi Kurihara; Judy Anderson; David G Roodman; Tony A Navas; Linda S Higgins
Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Experimental cell research 2006;312(10):1909-23.
2006: Tony A Navas; Aaron N Nguyen; Teru Hideshima; Mamatha Reddy; Jing Ying Ma; Edwin Haghnazari; Margaret Henson; Elizabeth G Stebbins; Irene Kerr; Gilbert O'Young; Ann M Kapoun; Sarvajit Chakravarty; Babu J Mavunkel; John J Perumattam; Gregory R Luedtke; Sundeep Dugar; Satyanarayana Medicherla; Protter Andrew; George F Schreiner; Kenneth C Anderson; Linda S Higgins
Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.
Leukemia 2006;20(6):1017-27.
2004: Moon Y Lim; Hui Wang; Ann M Kapoun; Maile O'connell; Gilbert O'Young; Heather Ann Brauer; Gregory R Luedtke; Sarvajit Chakravarty; Sundeep Dugar; George S Schreiner; Protter Andrew; Linda S Higgins
p38 Inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells.
Journal of molecular and cellular cardiology 2004;37(6):1111-4.
2004: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenji Ishitsuka; Constantine S Mitsiades; Yu-Tzu Tai; Makoto Hamasaki; Noopur Raje; Hiromasa Hideshima; George F Schreiner; Aaron N Nguyen; Tony A Navas; Nikhil C Munshi; Paul G Richardson; Linda S Higgins; Kenneth C Anderson
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
2004: Toshiaki Hayashi; Teru Hideshima; Aaron N Nguyen; Olivier Munoz; klaus podar; Makoto Hamasaki; Kenji Ishitsuka; Hiroshi Yasui; Paul Richardson; Sarvajit Chakravarty; Alison Murphy; Dharminder Chauhan; Linda S Higgins; Kenneth C Anderson
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7540-6.
2004: Martin Uhl; Steffen Aulwurm; Jörg Wischhusen; Markus Weiler; Jing Ying Ma; Ramona Almirez; Ruban Mangadu; Yu-Wang Liu; Michael Platten; Ulrich Herrlinger; Alison Murphy; Darren H Wong; Wolfgang Wick; Linda S Higgins; Michael Weller
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
Cancer research 2004;64(21):7954-61.