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Douglas Higgs

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Jim R Hughes; Karen M Lower; Simon McGowan; Jiannis Ragoussis; Jacqueline A Sloane-Stanley; Stephen Taylor; Douglas Vernimmen; Marco De Gobbi; Ian Dunham; Richard J Gibbons; Douglas R Higgs
High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
Douglas R Higgs
The molecular basis of α-thalassemia.
Monika S Kowalczyk; Gillian M Morriss-Kay; Chris P Ponting; Amy E Roberts; Luis Sanchez-Pulido; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Leslie B Smoot; Dorota Szumska; Hugh Watkins; William G Wood; Christian Babbs; Shoumo Bhattacharya; Richard J Gibbons; Jim R Hughes; Douglas R Higgs
Nprl3 is required for normal development of the cardiovascular system.

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2013: Jim R Hughes; Karen M Lower; Simon McGowan; Jiannis Ragoussis; Jacqueline A Sloane-Stanley; Stephen Taylor; Douglas Vernimmen; Marco De Gobbi; Ian Dunham; Richard J Gibbons; Douglas R Higgs
High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1620):20120361.
2013: Douglas R Higgs
The molecular basis of α-thalassemia.
Cold Spring Harbor perspectives in medicine 2013;3(1):a011718.
2012: Monika S Kowalczyk; Gillian M Morriss-Kay; Chris P Ponting; Amy E Roberts; Luis Sanchez-Pulido; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Leslie B Smoot; Dorota Szumska; Hugh Watkins; William G Wood; Christian Babbs; Shoumo Bhattacharya; Richard J Gibbons; Jim R Hughes; Douglas R Higgs
Nprl3 is required for normal development of the cardiovascular system.
Mammalian genome : official journal of the International Mammalian Genome Society 2012;23(7-8):404-15.
2012: Monika S Kowalczyk; Magnus D Lynch; Simon J McGowan; Thomas A Milne; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Stephen Taylor; Douglas Vernimmen; William G Wood; Jill M Brown; Veronica Buckle; Licio Collavin; Marco De Gobbi; Jonathan Flint; David Garrick; Richard J Gibbons; Nicola E Gray; Mona Hosseini; Jim R Hughes; Douglas R Higgs
Intragenic enhancers act as alternative promoters.
Molecular cell 2012;45(4):447-58.
2012: Douglas R Higgs; James Douglas Engel; George Stamatoyannopoulos
Thalassaemia.
Lancet 2012;379(9813):373-83.
2012: Magnus D Lynch; Stephen Meek; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Andrew J H Smith; Linda Sutherland; Douglas Vernimmen; Helena Ayyub; Tom Burdon; Marco De Gobbi; Maria Flenley; David Garrick; Richard J Gibbons; Jim R Hughes; Douglas R Higgs
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.
The EMBO journal 2012;31(2):317-29.
2011: Douglas Vernimmen; Marco De Gobbi; David Garrick; Magnus D Lynch; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Andrew J H Smith; Douglas R Higgs
Polycomb eviction as a new distant enhancer function.
Genes & development 2011;25(15):1583-8.
2011: Raffaele Renella; Nigel A Roberts; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Louise Bird; Jill M Brown; Veronica Buckle; Jacqueline Cordell; Marco De Gobbi; David J P Ferguson; Tasneem Hassanali; Douglas R Higgs; William G Wood
Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.
Blood 2011;117(25):6928-38.
2011: Alison T Merryweather-Clarke; Ann Atzberger; Shamit Soneji; Nicki Gray; Kevin Clark; Craig Waugh; Simon J McGowan; Stephen Taylor; Asoke K Nandi; William G Wood; David J Roberts; Douglas R Higgs; Veronica Buckle; Kathryn J H Robson
Global gene expression analysis of human erythroid progenitors.
Blood 2011;117(13):e96-108.
2011: Marco De Gobbi; Tariq Enver; David Garrick; Richard J Gibbons; Nicolas Goardon; Jim R Hughes; Sten Eirik W Jacobsen; Karen M Lower; Sidinh Luc; Magnus Lynch; Cristina Pina; Raffaele Renella; Jacqueline A Sloane-Stanley; Shamit Soneji; Stephen Taylor; Douglas Vernimmen; Paresh Vyas; Douglas R Higgs
Generation of bivalent chromatin domains during cell fate decisions.
Epigenetics & chromatin 2011;4(1):9.
2010: Martin J Law; Karen M Lower; Hsiao P J Voon; Jim R Hughes; David Garrick; Vip Viprakasit; Matthew Mitson; Marco De Gobbi; Marco Marra; Andrew Morris; Aaron Abbott; Steven P Wilder; Stephen Taylor; Guilherme M Santos; Joe Cross; Helena Ayyub; Steven Jones; Jiannis Ragoussis; Daniela Rhodes; Ian Dunham; Douglas R Higgs; Richard J Gibbons
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Cell 2010;143(3):367-78.
2010: Cornelis L Harteveld; Douglas R Higgs
Alpha-thalassaemia.
Orphanet journal of rare diseases 2010;5():13.
2009: Karen M Lower; Jim R Hughes; Marco De Gobbi; Shirley Henderson; Vip Viprakasit; Chris Fisher; Anne Goriely; Helena Ayyub; Jacqueline A Sloane-Stanley; Douglas Vernimmen; Cordelia Langford; David Garrick; Richard J Gibbons; Douglas R Higgs
Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21771-6.
2009: Douglas Vernimmen; Fatima Marques-Kranc; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; William G Wood; Helen A C Wallace; Andrew J H Smith; Douglas R Higgs
Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).
Blood 2009;114(19):4253-60.
2009: Douglas R Higgs; David J Weatherall
The alpha thalassaemias.
Cellular and molecular life sciences : CMLS 2009;66(7):1154-62.
2008: Claudia Seah; Michael A Levy; Yan Jiang; Sulayman Mokhtarzada; Douglas R Higgs; Richard J Gibbons; Nathalie G Bérubé
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12570-80.
2008: David Garrick; Marco De Gobbi; Vasiliki Samara; Michelle Rugless; Michelle Holland; Helena Ayyub; Karen Lower; Jacqueline A Sloane-Stanley; Nicki Gray; Christoph Koch; Carl Bruder; Douglas R Higgs
The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
Blood 2008;112(9):3889-99.
2008: Michelle J Rugless; Chris A Fisher; John M Old; Jacqueline A Sloane-Stanley; Helena Ayyub; Douglas R Higgs; David Garrick
A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.
Human molecular genetics 2008;17(19):3084-93.
2008: Jill M Brown; Joanne Green; Ricardo Neves; Helen A C Wallace; Andrew J H Smith; Jim Hughes; Nicki Gray; Steve Taylor; William G Wood; Douglas R Higgs; Francisco J Iborra; Veronica Buckle
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
The Journal of cell biology 2008;182(6):1083-97.
2008: Douglas R Higgs; William G Wood
Genetic complexity in sickle cell disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11595-6.
2008: David Garrick; Marco De Gobbi; Magnus Lynch; Douglas R Higgs
Switching genes on and off in haemopoiesis.
Biochemical Society transactions 2008;36(Pt 4):613-8.
2008: Douglas R Higgs; William G Wood
Long-range regulation of alpha globin gene expression during erythropoiesis.
Current opinion in hematology 2008;15(3):176-83.
2008: Douglas R Higgs
A new dawn for stem-cell therapy.
The New England journal of medicine 2008;358(9):964-6.
2008: Douglas R Higgs; Douglas Vernimmen; Bill Wood
Long-range regulation of alpha-globin gene expression.
Advances in genetics 2008;61():143-73.
2007: Marco De Gobbi; Eduardo Anguita; Jim Hughes; Jacqueline A Sloane-Stanley; Jacqueline A Sharpe; Christoph M Koch; Carl Bruder; Richard J Gibbons; William G Wood; Douglas R Higgs
Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.
Blood 2007;110(13):4503-10.
2007: Anthony Argentaro; Ji-Chun Yang; Lynda Chapman; Monika S Kowalczyk; Richard J Gibbons; Douglas R Higgs; David Neuhaus; Daniela Rhodes
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):11939-44.
2007: Mary R Muers; Jacqueline A Sharpe; David Garrick; Jacqueline A Sloane-Stanley; Patrick M Nolan; Terry Hacker; William G Wood; Douglas R Higgs; Richard J Gibbons
Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.
American journal of human genetics 2007;80(6):1138-49.
2007: Douglas Vernimmen; Marco De Gobbi; Jacqueline A Sloane-Stanley; William G Wood; Douglas R Higgs
Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.
The EMBO journal 2007;26(8):2041-51.
2007: Helen A C Wallace; Fatima Marques-Kranc; Melville Richardson; Francisco Luna-Crespo; Jacqueline A Sharpe; Jim Hughes; William G Wood; Douglas R Higgs; Andrew J H Smith
Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.
Cell 2007;128(1):197-209.
2007: Douglas R Higgs; Douglas Vernimmen; Jim Hughes; Richard Gibbons
Using genomics to study how chromatin influences gene expression.
Annual review of genomics and human genetics 2007;8():299-325.
2006: Marco De Gobbi; Vip Viprakasit; Jim R Hughes; Chris Fisher; Veronica Buckle; Helena Ayyub; Richard J Gibbons; Douglas Vernimmen; Yuko Yoshinaga; Pieter de Jong; Jan-Fang Cheng; Edward M Rubin; William G Wood; Don Bowden; Douglas R Higgs
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.
Science (New York, N.Y.) 2006;312(5777):1215-7.
2006: Vip Viprakasit; Cornelis L Harteveld; Helena Ayyub; Jackie S Stanley; Piero C Giordano; William G Wood; Douglas R Higgs
A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.
Blood 2006;107(9):3811-2.
2006: Daniel B Costa; Christopher A Fisher; Kenneth B Miller; German Pihan; David P Steensma; Richard J Gibbons; Douglas R Higgs
A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome.
European journal of haematology 2006;76(5):432-5, 453.
2006: David Garrick; Jacqueline A Sharpe; Ruth Arkell; Lorraine Dobbie; Andrew J H Smith; William G Wood; Douglas R Higgs; Richard J Gibbons
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
PLoS genetics 2006;2(4):e58.
2006: Jill M Brown; Joanne Leach; Joyce E Reittie; Ann Atzberger; Jane Lee-Prudhoe; William G Wood; Douglas R Higgs; Francisco J Iborra; Veronica Buckle
Coregulated human globin genes are frequently in spatial proximity when active.
The Journal of cell biology 2006;172(2):177-87.
2006: Douglas R Higgs; Douglas Vernimmen; Marco De Gobbi; Eduardo Anguita; Jim Hughes; Veronica Buckle; Francisco J Iborra; David Garrick; William G Wood
How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation.
Biochemical Society symposium 2006;(73):11-22.
2005: Jim R Hughes; Jan-Fang Cheng; Nicki Ventress; Shyam Prabhakar; Kevin Clark; Eduardo Anguita; Marco De Gobbi; Pieter de Jong; Eddy Rubin; Douglas R Higgs
Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9830-5.
2005: Nathalie G Bérubé; Marie Mangelsdorf; Magdalena Jagla; Jacqueline L Vanderluit; David Garrick; Richard J Gibbons; Douglas R Higgs; ruth slack; David J Picketts
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
The Journal of clinical investigation 2005;115(2):258-67.
2005: David P Steensma; Richard J Gibbons; Douglas R Higgs
Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies.
Blood 2005;105(2):443-52.
2005: Douglas R Higgs; David Garrick; Eduardo Anguita; Marco De Gobbi; Jim Hughes; M Muers; Douglas Vernimmen; K Lower; M Law; Anthony Argentaro; Marie-Alice Deville; Richard Gibbons
Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.
Annals of the New York Academy of Sciences 2005;1054():92-102.
2005: Thomas S Price; Regina Regan; Richard Mott; Asa Hedman; Ben Honey; Rachael J Daniels; Lee Smith; Andy Greenfield; Ana Tiganescu; Veronica Buckle; Nicki Ventress; Helena Ayyub; Anita Salhan; Susana Pedraza-Diaz; John Broxholme; Jiannis Ragoussis; Douglas R Higgs; Jonathan Flint; Samantha J L Knight
SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data.
Nucleic acids research 2005;33(11):3455-64.
2004: Eduardo Anguita; Jim Hughes; Clare Heyworth; Gerd A Blobel; William G Wood; Douglas R Higgs
Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2.
The EMBO journal 2004;23(14):2841-52.
2004: Vip Viprakasit; Voravarn S Tanphaichitr; Worrawut Chinchang; Pakarat Sangkla; Mitchell J Weiss; Douglas R Higgs
Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.
Blood 2004;103(9):3296-9.
2004: Cristina Tufarelli; Ross Hardison; Webb Miller; Jim Hughes; Kevin Clark; Nicki Ventress; Anna-Maria Frischauf; Douglas R Higgs
Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.
Genome research 2004;14(4):623-30.
2004: David P Steensma; Douglas R Higgs; Christopher A Fisher; Richard J Gibbons
Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations.
Blood 2004;103(6):2019-26.
2004: Vip Viprakasit; Voravarn S Tanphaichitr; Gavivann Veerakul; Worrawut Chinchang; Siripan Petrarat; Parichat Pung-Amritt; Douglas R Higgs
Co-inheritance of Hb Pak Num Po, a novel alpha1 gene mutation, and alpha0 thalassemia associated with transfusion-dependent Hb H disease.
American journal of hematology 2004;75(3):157-63.
2004: David P Steensma; Vip Viprakasit; Alex Hendrick; David K Goff; Joanne Leach; Richard J Gibbons; Douglas R Higgs
Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
Blood 2004;103(4):1518-20.
2004: David Garrick; Vassiliki Samara; Tarra McDowell; Andrew J H Smith; Lorraine Dobbie; Douglas R Higgs; Richard J Gibbons
A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domain.
Gene 2004;326():23-34.
2004: Douglas R Higgs
Gene regulation in hematopoiesis: new lessons from thalassemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2004;():1-13.
2003: Richard J Gibbons; Andrea Pellagatti; David Garrick; William G Wood; Nicola Malik; Helena Ayyub; Cordelia Langford; Jacqueline Boultwood; james wainscoat; Douglas R Higgs
Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).
Nature genetics 2003;34(4):446-9.
2003: Cristina Tufarelli; Jackie A Sloane Stanley; David Garrick; Jacqueline A Sharpe; Helena Ayyub; William G Wood; Douglas R Higgs
Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease.
Nature genetics 2003;34(2):157-65.
2003: Vip Viprakasit; Alexa M J Kidd; Helena Ayyub; Sharon W Horsley; Jim Hughes; Douglas R Higgs
De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia.
British journal of haematology 2003;120(5):867-75.
2002: Eduardo Anguita; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Cristina Tufarelli; Douglas R Higgs; William G Wood
Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.
Blood 2002;100(10):3450-6.
2002: Vip Viprakasit; Sarah Green; Susan E Height; Helena Ayyub; Douglas R Higgs
Hb H hydrops fetalis syndrome associated with the interaction of two common determinants of alpha thalassaemia (--MED/(alpha)TSaudi(alpha)).
British journal of haematology 2002;117(3):759-62.
2002: Vip Viprakasit; Voravarn S Tanphaichitr; Parichat Pung-Amritt; Siripan Petrarat; Lerlugsn Suwantol; Chris Fisher; Douglas R Higgs
Clinical phenotypes and molecular characterization of Hb H-Paksé disease.
Haematologica 2002;87(2):117-25.
2001: Vip Viprakasit; Richard J Gibbons; Bernard C Broughton; J L Tolmie; D Brown; P Lunt; Robin M Winter; S Marinoni; Miria Stefanini; Louise A Brueton; Alan Lehmann; Douglas R Higgs
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Human molecular genetics 2001;10(24):2797-802.
2001: Eduardo Anguita; C A Johnson; William G Wood; B M Turner; Douglas R Higgs
Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12114-9.
2001: Andreas Tiede; Rachael J Daniels; Douglas R Higgs; Y Mehrein; Reinhold E Schmidt; Jörg Schubert
The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis.
Gene 2001;271(2):247-54.
2001: Karen E Brown; S Amoils; J M Horn; Veronica Buckle; Douglas R Higgs; Matthias Merkenschlager; Amanda G Fisher
Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells.
Nature cell biology 2001;3(6):602-6.
2001: Sharon W Horsley; Rachael J Daniels; Eduardo Anguita; H A Raynham; JF Peden; Ana Villegas; M A Vickers; S Green; J S Waye; D H Chui; Helena Ayyub; A B MacCarthy; Veronica Buckle; Richard J Gibbons; Lyndal Kearney; Douglas R Higgs
Monosomy for the most telomeric, gene-rich region of the short arm of human chromosome 16 causes minimal phenotypic effects.
European journal of human genetics : EJHG 2001;9(3):217-25.
2001: Jonathan Flint; Cristina Tufarelli; JF Peden; Kevin Clark; Rachael J Daniels; Ross Hardison; Webb Miller; Sjaak Philipsen; Kian-Cheng Tan-Un; Tara McMorrow; Jon Frampton; BLANCHE ALTER; Anna-Maria Frischauf; Douglas R Higgs
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.
Human molecular genetics 2001;10(4):371-82.
2001: Rachael J Daniels; JF Peden; C Lloyd; Sharon W Horsley; Kevin Clark; Cristina Tufarelli; Lyndal Kearney; Veronica Buckle; N A Doggett; Jonathan Flint; Douglas R Higgs
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Human molecular genetics 2001;10(4):339-52.
2001: Cristina Tufarelli; Anna-Maria Frischauf; Ross Hardison; Jonathan Flint; Douglas R Higgs
Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.
Genomics 2001;71(3):307-14.
2000: Samuel S Chong; Corinne D Boehm; Garry R Cutting; Douglas R Higgs
Simplified multiplex-PCR diagnosis of common southeast asian deletional determinants of alpha-thalassemia.
Clinical chemistry 2000;46(10):1692-5.
2000: V M Barbour; Cristina Tufarelli; Jacqueline A Sharpe; Z E Smith; Helena Ayyub; C A Heinlein; Jacqueline A Sloane-Stanley; K Indrak; William G Wood; Douglas R Higgs
alpha-thalassemia resulting from a negative chromosomal position effect.
Blood 2000;96(3):800-7.
2000: Richard J Gibbons; Tarra McDowell; S Raman; D M O'Rourke; David Garrick; Helena Ayyub; Douglas R Higgs
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.
Nature genetics 2000;24(4):368-71.
2000: Samuel S Chong; Corinne D Boehm; Douglas R Higgs; Garry R Cutting
Single-tube multiplex-PCR screen for common deletional determinants of alpha-thalassemia.
Blood 2000;95(1):360-2.
1999: Tarra McDowell; Richard J Gibbons; H Sutherland; D M O'Rourke; Wendy A Bickmore; A Pombo; Helen Turley; Kevin Gatter; David J Picketts; Veronica Buckle; L Chapman; D Rhodes; Douglas R Higgs
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13983-8.
1999: Z E Smith; Douglas R Higgs
The pattern of replication at a human telomeric region (16p13.3): its relationship to chromosome structure and gene expression.
Human molecular genetics 1999;8(8):1373-86.
1999: Douglas R Higgs; Helena Ayyub; Samuel S Chong
The--THAI and--FIL determinants of alpha thalassemia in Taiwan.
American journal of hematology 1999;60(1):80-1.
1998: Douglas R Higgs
Do LCRs open chromatin domains?
Cell 1998;95(3):299-302.
1998: David J Picketts; A O Tastan; Douglas R Higgs; Richard J Gibbons
Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(5):400-3.
1998: Douglas R Higgs; Jacqueline A Sharpe; William G Wood
Understanding alpha globin gene expression: a step towards effective gene therapy.
Seminars in hematology 1998;35(2):93-104.
1997: Richard J Gibbons; S Bachoo; David J Picketts; Salim Aftimos; B Asenbauer; J Bergoffen; S A Berry; N Dahl; A Fryer; K Keppler; K Kurosawa; M L Levin; M Masuno; G Neri; Mary Ella Pierpont; S F Slaney; Douglas R Higgs
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
Nature genetics 1997;17(2):146-8.
1997: Jonathan Flint; Gillian P Bates; Kevin Clark; A Dorman; D Willingham; B A Roe; G Micklem; Douglas R Higgs; Edward J Louis
Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains.
Human molecular genetics 1997;6(8):1305-13.
1997: Jonathan Flint; K Thomas; G Micklem; H Raynham; Kevin Clark; N A Doggett; A King; Douglas R Higgs
The relationship between chromosome structure and function at a human telomeric region.
Nature genetics 1997;15(3):252-7.
1996: David J Picketts; Douglas R Higgs; S Bachoo; Derek J Blake; O W Quarrell; Richard J Gibbons
ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.
Human molecular genetics 1996;5(12):1899-907.
1996: Jonathan Flint; Jacques Rochette; Charles Craddock; Catherine Dodé; B Vignes; Sharon W Horsley; Lyndal Kearney; V J Buckle; H Ayyub; Douglas R Higgs
Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements.
Human molecular genetics 1996;5(8):1163-9.
1996: Richard J Gibbons; Douglas R Higgs
The alpha-thalassemia/mental retardation syndromes.
Medicine 1996;75(2):45-52.
1995: P Vyas; M A Vickers; David J Picketts; Douglas R Higgs
Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
Genomics 1995;29(3):679-89.
1995: G Gourdon; Jacqueline A Sharpe; Douglas R Higgs; William G Wood
The mouse alpha-globin locus regulatory element.
Blood 1995;86(2):766-75.
1995: Charles Craddock; P Vyas; Jacqueline A Sharpe; H Ayyub; William G Wood; Douglas R Higgs
Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
The EMBO journal 1995;14(8):1718-26.
1995: Richard J Gibbons; David J Picketts; L Villard; Douglas R Higgs
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome).
Cell 1995;80(6):837-45.
1995: Richard J Gibbons; David J Picketts; Douglas R Higgs
Syndromal mental retardation due to mutations in a regulator of gene expression.
Human molecular genetics 1995;4 Spec No():1705-9.
1994: G Gourdon; Jacqueline A Sharpe; D Wells; William G Wood; Douglas R Higgs
Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice.
Nucleic acids research 1994;22(20):4139-47.
1994: Jonathan Flint; Charles Craddock; A Villegas; D P Bentley; H J Williams; R Galanello; A Cao; William G Wood; H Ayyub; Douglas R Higgs
Healing of broken human chromosomes by the addition of telomeric repeats.
American journal of human genetics 1994;55(3):505-12.
1993: Jacqueline A Sharpe; D J Wells; E Whitelaw; P Vyas; Douglas R Higgs; William G Wood
Analysis of the human alpha-globin gene cluster in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11262-6.
1993: Georgina W Hall; Swee Lay Thein; A C Newland; M Chisholm; Joanne Traeger-Synodinos; Emmanuel Kanavakis; Christos Kattamis; Douglas R Higgs
A base substitution (T-->C) in codon 29 of the alpha 2-globin gene causes alpha thalassaemia.
British journal of haematology 1993;85(3):546-52.
1993: Douglas R Higgs
The thalassaemia syndromes.
The Quarterly journal of medicine 1993;86(9):559-64.
1993: Jacqueline A Sharpe; R J Summerhill; P Vyas; G Gourdon; Douglas R Higgs; William G Wood
Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression.
Blood 1993;82(5):1666-71.
1993: M A Vickers; P Vyas; Peter C Harris; D L Simmons; Douglas R Higgs
Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3437-41.
1993: J Lamb; Peter C Harris; Andrew O M Wilkie; William G Wood; J G Dauwerse; Douglas R Higgs
De novo truncation of chromosome 16p and healing with (TTAGGG)n in the alpha-thalassemia/mental retardation syndrome (ATR-16).
American journal of human genetics 1993;52(4):668-76.
1993: Douglas R Higgs
alpha-Thalassaemia.
Baillière's clinical haematology 1993;6(1):117-50.
1992: Jacqueline A Sharpe; P S Chan-Thomas; J Lida; H Ayyub; William G Wood; Douglas R Higgs
Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.
The EMBO journal 1992;11(12):4565-72.
1992: Richard J Gibbons; G K Suthers; Andrew O M Wilkie; V J Buckle; Douglas R Higgs
X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome: localization to Xq12-q21.31 by X inactivation and linkage analysis.
American journal of human genetics 1992;51(5):1136-49.
1992: P Vyas; Jacqueline A Sharpe; P Watt; Douglas R Higgs; William G Wood
Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells.
Blood 1992;80(7):1832-7.
1992: P Vyas; M A Vickers; D L Simmons; H Ayyub; Charles Craddock; Douglas R Higgs
Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.
Cell 1992;69(5):781-93.
1992: Andrew O M Wilkie; Douglas R Higgs
An unusually large (CA)n repeat in the region of divergence between subtelomeric alleles of human chromosome 16p.
Genomics 1992;13(1):81-8.
1991: Richard J Gibbons; A O Wilkie; David J Weatherall; Douglas R Higgs
A newly defined X linked mental retardation syndrome associated with alpha thalassaemia.
Journal of medical genetics 1991;28(11):729-33.
1991: A P Jarman; William G Wood; Jacqueline A Sharpe; G Gourdon; H Ayyub; Douglas R Higgs
Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.
Molecular and cellular biology 1991;11(9):4679-89.
1991: Andrew O M Wilkie; Douglas R Higgs; KA Rack; V J Buckle; N K Spurr; N Fischel-Ghodsian; Isabella Ceccherini; W R Brown; Peter C Harris
Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16.
Cell 1991;64(3):595-606.
1990: Douglas R Higgs; William G Wood; A P Jarman; J Sharpe; J Lida; I M Pretorius; H Ayyub
A major positive regulatory region located far upstream of the human alpha-globin gene locus.
Genes & development 1990;4(9):1588-601.
1990: Andrew O M Wilkie; J Lamb; Peter C Harris; R D Finney; Douglas R Higgs
A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n.
Nature 1990;346(6287):868-71.
1990: Douglas R Higgs
1990 Mack Forster Prize lecture. The molecular genetics of the alpha globin gene family.
European journal of clinical investigation 1990;20(4):340-7.
1990: C S Hatton; Andrew O M Wilkie; H C Drysdale; William G Wood; M A Vickers; J Sharpe; H Ayyub; I M Pretorius; V J Buckle; Douglas R Higgs
Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.
Blood 1990;76(1):221-7.
1990: Peter C Harris; N J Barton; Douglas R Higgs; S T Reeders; Andrew O M Wilkie
A long-range restriction map between the alpha-globin complex and a marker closely linked to the polycystic kidney disease 1 (PKD1) locus.
Genomics 1990;7(2):195-206.
1990: Andrew O M Wilkie; H C Zeitlin; R H Lindenbaum; V J Buckle; N Fischel-Ghodsian; D H Chui; D Gardner-Medwin; M H MacGillivray; David J Weatherall; Douglas R Higgs
Clinical features and molecular analysis of the alpha thalassemia/mental retardation syndromes. II. Cases without detectable abnormality of the alpha globin complex.
American journal of human genetics 1990;46(6):1127-40.
1990: Gregory G Germino; N J Barton; J Lamb; Douglas R Higgs; P Harris; G H Xiao; G Scherer; Y Nakamura; S T Reeders
Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16.
American journal of human genetics 1990;46(5):925-33.
1990: A Villegas; F Calero; M A Vickers; H Ayyub; Douglas R Higgs
Alpha thalassaemia in two Spanish families.
European journal of haematology 1990;44(2):109-15.
1990: Douglas R Higgs; William G Wood; A P Jarman; M A Vickers; Andrew O M Wilkie; J Lamb; P Vyas; J P Bennett
The alpha-thalassemias.
Annals of the New York Academy of Sciences 1990;612():15-22.
1989: J Lamb; Andrew O M Wilkie; Peter C Harris; V J Buckle; R H Lindenbaum; N J Barton; S T Reeders; David J Weatherall; Douglas R Higgs
Detection of breakpoints in submicroscopic chromosomal translocation, illustrating an important mechanism for genetic disease.
Lancet 1989;2(8667):819-24.
1989: Douglas R Higgs; M A Vickers; Andrew O M Wilkie; I M Pretorius; A P Jarman; David J Weatherall
A review of the molecular genetics of the human alpha-globin gene cluster.
Blood 1989;73(5):1081-104.
1988: V J Buckle; Douglas R Higgs; Andrew O M Wilkie; M Super; David J Weatherall
Localisation of human alpha globin to 16p13.3----pter.
Journal of medical genetics 1988;25(12):847-9.
1988: A P Jarman; Douglas R Higgs
Nuclear scaffold attachment sites in the human globin gene complexes.
The EMBO journal 1988;7(11):3337-44.
1988: N Fischel-Ghodsian; M A Vickers; M Seip; P Winichagoon; Douglas R Higgs
Characterization of two deletions that remove the entire human zeta-alpha globin gene complex (- -THAI and - -FIL).
British journal of haematology 1988;70(2):233-8.
1987: N Fischel-Ghodsian; R D Nicholls; Douglas R Higgs
Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene.
Nucleic acids research 1987;15(22):9215-25.
1987: AG Falusi; G J Esan; H Ayyub; Douglas R Higgs
Alpha-thalassaemia in Nigeria: its interaction with sickle-cell disease.
European journal of haematology 1987;38(4):370-5.
1986: Douglas R Higgs; james wainscoat; Jonathan Flint; A V Hill; S L Thein; R D Nicholls; H Teal; H Ayyub; T E Peto; AG Falusi
Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(14):5165-9.
1985: Douglas R Higgs; H Ayyub; J B Clegg; A V Hill; R D Nicholls; H Teal; james wainscoat; D J Weatherall
Alpha thalassaemia in British people.
British medical journal (Clinical research ed.) 1985;290(6478):1303-6.
1985: Douglas R Higgs; A V Hill; R Nicholls; S E Goodbourn; H Ayyub; H Teal; J B Clegg; D J Weatherall
Molecular rearrangements of the human alpha-globin gene cluster.
Annals of the New York Academy of Sciences 1985;445():45-56.