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Osamu Higuchi

Research Profile

Chemicals & Drugs

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Congenital Myasthenic Syndromes

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Publications

TOP 3
Osamu Higuchi; Yuji Yamanashi
[Molecular mechanisms underlying the formation of neuromuscular junction].
Johko Hamuro; Yukihiro Hishida; Osamu Higuchi; Yuji Yamanashi
The transcription factor Sp1 plays a crucial role in dok-7 gene expression.
Akane Inoue; Kiyoko Setoguchi; Yosuke Matsubara; Kumiko Okada; Nozomi Sato; Yoichiro Iwakura; Osamu Higuchi; Yuji Yamanashi
Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.

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All Publications

2011: Osamu Higuchi; Yuji Yamanashi
[Molecular mechanisms underlying the formation of neuromuscular junction].
Brain and nerve = Shinkei kenkyū no shinpo 2011;63(7):649-55.
2011: Johko Hamuro; Yukihiro Hishida; Osamu Higuchi; Yuji Yamanashi
The transcription factor Sp1 plays a crucial role in dok-7 gene expression.
Biochemical and biophysical research communications 2011;408(2):293-9.
2009: Akane Inoue; Kiyoko Setoguchi; Yosuke Matsubara; Kumiko Okada; Nozomi Sato; Yoichiro Iwakura; Osamu Higuchi; Yuji Yamanashi
Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.
Science signaling 2009;2(59):ra7.
2008: Johko Hamuro; Osamu Higuchi; Kumiko Okada; Makiko Ueno; Shun-ichiro Iemura; Tohru Natsume; Hayley Spearman; David Beeson; Yuji Yamanashi
Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.
The Journal of biological chemistry 2008;283(9):5518-24.
2006: David Beeson; Osamu Higuchi; Jacqueline Palace; Judy Cossins; Hayley Spearman; Susan Maxwell; John Newsom-Davis; Georgina Burke; Peter R W Fawcett; Masakatsu Motomura; Juliane S Müller; Hanns Lochmüller; Clarke Slater; Angela Vincent; Yuji Yamanashi
Dok-7 mutations underlie a neuromuscular junction synaptopathy.
Science (New York, N.Y.) 2006;313(5795):1975-8.
2006: Kumiko Okada; Akane Inoue; Momoko Okada; Yoji Murata; Shigeru Kakuta; Takafumi Jigami; Sachiko Kubo; Hirokazu Shiraishi; Katsumi Eguchi; Masakatsu Motomura; Tetsu Akiyama; Yoichiro Iwakura; Osamu Higuchi; Yuji Yamanashi
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Science (New York, N.Y.) 2006;312(5781):1802-5.
2006: Miyuki Honma; Osamu Higuchi; Masaki Shirakata; Tomoharu Yasuda; Hiroshi Shibuya; Shun-ichiro Iemura; Tohru Natsume; Yuji Yamanashi
Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(2):143-51.
2004: Takashi Sekiya; Shungo Adachi; Kazuyoshi Kohu; Tatsuya Yamada; Osamu Higuchi; Yoichi Furukawa; Yusuke Nakamura; Tsutomu Nakamura; Kousuke Tashiro; Satoru Kuhara; Susumu Ohwada; Tetsu Akiyama
Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.
The Journal of biological chemistry 2004;279(8):6840-6.
2000: Yoshihiro Kawasaki; Takao Senda; T Ishidate; Ryuta Koyama; T Morishita; Y Iwayama; Osamu Higuchi; Tetsu Akiyama
Asef, a link between the tumor suppressor APC and G-protein signaling.
Science (New York, N.Y.) 2000;289(5482):1194-7.