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Rüdiger Hilker

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Simon Baudrexel; Torsten Witte; Carola Seifried; Frederic von Wegner; Florian Beissner; Johannes C Klein; Helmuth Steinmetz; Ralf Deichmann; Jochen Roeper; Rüdiger Hilker
Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease.
C Eggers; A Schmidt; Johann Hagenah; N Brüggemann; J C Klein; V Tadic; L Kertelge; M Kasten; Ferdinand Binkofski; Hartwig R Siebner; B Neumaier; G R Fink; Rüdiger Hilker; Christine Klein
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit.
Simon Baudrexel; Lucas Nürnberger; Udo Rüb; Carola Seifried; Johannes C Klein; Thomas Deller; Helmuth Steinmetz; Ralf Deichmann; Rüdiger Hilker
Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease.

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All Publications

2011: Simon Baudrexel; Torsten Witte; Carola Seifried; Frederic von Wegner; Florian Beissner; Johannes C Klein; Helmuth Steinmetz; Ralf Deichmann; Jochen Roeper; Rüdiger Hilker
Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease.
NeuroImage 2011;55(4):1728-38.
2010: C Eggers; A Schmidt; Johann Hagenah; N Brüggemann; J C Klein; V Tadic; L Kertelge; M Kasten; Ferdinand Binkofski; Hartwig R Siebner; B Neumaier; G R Fink; Rüdiger Hilker; Christine Klein
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit.
Neurology 2010;74(22):1798-805.
2010: Simon Baudrexel; Lucas Nürnberger; Udo Rüb; Carola Seifried; Johannes C Klein; Thomas Deller; Helmuth Steinmetz; Ralf Deichmann; Rüdiger Hilker
Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease.
NeuroImage 2010;51(2):512-20.
2009: Simon Baudrexel; Steffen Volz; Christine Preibisch; Johannes C Klein; Helmuth Steinmetz; Rüdiger Hilker; Ralf Deichmann
Rapid single-scan T2*-mapping using exponential excitation pulses and image-based correction for linear background gradients.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2009;62(1):263-8.
2009: Lars Timmermann; Günther Deuschl; W Fogel; Rüdiger Hilker; Andreas Kupsch; M Lange; C Schrader; F Sixel-Döring; Jens Volkmann; R Benecke
[Deep brain stimulation for tremor in multiple sclerosis : consensus recommendations of the German Deep Brain Stimulation Association].
Der Nervenarzt 2009;80(6):673-7.
2009: Jun-Suk Kang; Karsten Krakow; Julia Roggendorf; Helmuth Steinmetz; Rüdiger Hilker
Botulinum toxin treatment of epilepsia partialis continua.
Movement disorders : official journal of the Movement Disorder Society 2009;24(1):141-3.
2009: C Eggers; Rüdiger Hilker; Lothar Burghaus; B Schumacher; Wolf-Dieter Heiss
High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease.
Journal of the neurological sciences 2009;276(1-2):27-30.
2009: Elke Kalbe; Jürgen Voges; T Weber; M Haarer; S Baudrexel; Johannes Christian Klein; J Kessler; Volker Sturm; Wolf-Dieter Heiss; Rüdiger Hilker
Frontal FDG-PET activity correlates with cognitive outcome after STN-DBS in Parkinson disease.
Neurology 2009;72(1):42-9.
2008: Norbert Galldiks; Alexander Thiel; Cathleen Haense; Gereon R Fink; Rüdiger Hilker
11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome.
Journal of neurology 2008;255(9):1361-4.
2008: Elke Kalbe; Pasquale Calabrese; Nils Kohn; Rüdiger Hilker; Oliver Riedel; Hans-Ulrich Wittchen; Richard Dodel; Jörg Otto; Georg Ebersbach; Josef Kessler
Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrument.
Parkinsonism & related disorders 2008;14(2):93-101.
2007: Johann Hagenah; Inke R König; B Becker; Rüdiger Hilker; Meike Kasten; Katja Hedrich; Peter P Pramstaller; Christine Klein; Günter Seidel
Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.
Journal of neurology 2007;254(10):1407-13.
2007: Ferdinand Binkofski; Kathrin Reetz; Christian Gaser; Rüdiger Hilker; Johann Hagenah; Katja Hedrich; Thilo van Eimeren; A Thiel; Christian Büchel; Peter P Pramstaller; Hartwig R Siebner; Christine Klein
Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia.
Neurology 2007;69(9):842-50.
2007: Jürgen Voges; Rüdiger Hilker; Kai Bötzel; Karl L Kiening; Manja Kloss; Andreas Kupsch; Alfons Schnitzler; Gerd-Helge Schneider; Ulrich Steude; Günther Deuschl; Marcus O Pinsker
Thirty days complication rate following surgery performed for deep-brain-stimulation.
Movement disorders : official journal of the Movement Disorder Society 2007;22(10):1486-9.
2007: Maria Adele Rueger; Lutz W Kracht; Rüdiger Hilker; Alexander Thiel; Jan Sobesky; Alexandra Winkeler; Anne V Thomas; Michael T Heneka; Rudolf Graf; Karl Herholz; Wolf-Dieter Heiss; Andreas H Jacobs
Role of in vivo imaging of the central nervous system for developing novel drugs.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2007;51(2):164-81.
2007: Julia Roggendorf; Lothar Burghaus; Wei-Chi Liu; Simon Weisenbach; Carsten Eggers; Gereon R Fink; Rüdiger Hilker
Belly dancer's syndrome following central pontine and extrapontine myelinolysis.
Movement disorders : official journal of the Movement Disorder Society 2007;22(6):892-4.
2007: Elke Kalbe; F Grabenhorst; M Brand; Josef Kessler; Rüdiger Hilker; Hans J Markowitsch
Elevated emotional reactivity in affective but not cognitive components of theory of mind: a psychophysiological study.
Journal of neuropsychology 2007;1(Pt 1):27-38.
2007: Lothar Burghaus; Rüdiger Hilker; Christian Dohmen; Bert Bosche; Lutz Winhuisen; Norbert Galldiks; Brigitte Szelies; Wolf-Dieter Heiss
Early electroencephalography in acute ischemic stroke: prediction of a malignant course?
Clinical neurology and neurosurgery 2007;109(1):45-9.
2006: Rüdiger Hilker; Lothar Burghaus; Noushin Razai; Andreas H Jacobs; Brigitte Szelies; Wolf-Dieter Heiss
Functional brain imaging in combined motor and sleep disorders.
Journal of the neurological sciences 2006;248(1-2):223-6.
2006: Katja Hedrich; Johann Hagenah; Ana Djarmati; Anja Hiller; Thora Lohnau; Kathrin Lasek; Anne Grünewald; Rüdiger Hilker; Susanne Steinlechner; Heather Boston; Norman Kock; Christiane Schneider-Gold; Wolfram Kress; Hartwig R Siebner; Ferdinand Binkofski; Rebekka Lencer; Alexander Münchau; Christine Klein
Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?
Archives of neurology 2006;63(6):833-8.
2006: Lothar Burghaus; Rüdiger Hilker; Alexander Thiel; Norbert Galldiks; Fritz-Georg Lehnhardt; Olivier Zaro Weber; Volker Sturm; Wolf-Dieter Heiss
Deep brain stimulation of the subthalamic nucleus reversibly deteriorates stuttering in advanced Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(5):625-31.
2006: A Thomas; Johannes Christian Klein; Norbert Galldiks; Rüdiger Hilker; M Grond; Andreas H Jacobs
Multitracer PET imaging in Heidenhain variant of Creutzfeldt-Jakob disease.
Journal of neurology 2006;253(2):258-60.
2006: Katherine J Schweitzer; Rüdiger Hilker; Uwe Walter; Lothar Burghaus; Daniela Berg
Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(1):94-8.
2005: Rüdiger Hilker; Anne V Thomas; Johannes Christian Klein; Simon Weisenbach; Elke Kalbe; Lothar Burghaus; Andreas H Jacobs; Karl Herholz; Wolf-Dieter Heiss
Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways.
Neurology 2005;65(11):1716-22.
2005: Andreas H Jacobs; Anne Thomas; Lutz W Kracht; Huongfeng Li; Claus Dittmar; Guido Garlip; Norbert Galldiks; Johannes Christian Klein; Jan Sobesky; Rüdiger Hilker; Stefan Vollmar; Karl Herholz; Klaus Wienhard; Wolf-Dieter Heiss
18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):1948-58.
2005: Jan Sobesky; Alexander Thiel; Mehran Ghaemi; Rüdiger Hilker; Jobst Rudolf; Andreas H Jacobs; Karl Herholz; Wolf-Dieter Heiss
Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(12):1685-91.
2005: Peter P Pramstaller; Michael G Schlossmacher; Thomas S Jacques; Francesco Scaravilli; Cordula Eskelson; Imelda Pepivani; Katja Hedrich; Susanna Adel; Melissa Gonzales-McNeal; Rüdiger Hilker; Patricia L Kramer; Christine Klein
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers.
Annals of neurology 2005;58(3):411-22.
2005: Rüdiger Hilker; Axel T Portman; Jürgen Voges; Michiel J Staal; Lothar Burghaus; Teus van Laar; Athanasios Koulousakis; R P Maguire; Jan Pruim; Bauke M de Jong; Karl Herholz; Volker Sturm; Wolf-Dieter Heiss; Klaus L Leenders
Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation.
Journal of neurology, neurosurgery, and psychiatry 2005;76(9):1217-21.
2005: Maria Adele Rueger; Alexandra Winkeler; Hrvoje Miletic; C Kaestle; R Richter; G Schneider; Rüdiger Hilker; Michael T Heneka; Ralf-Ingo Ernestus; J A Hampl; Cornel Fraefel; Andreas H Jacobs
Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors.
Gene therapy 2005;12(7):588-96.
2005: Rüdiger Hilker; Katherine J Schweitzer; Silke Coburger; Mehran Ghaemi; Simon Weisenbach; Andreas H Jacobs; Jobst Rudolf; Karl Herholz; Wolf-Dieter Heiss
Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity.
Archives of neurology 2005;62(3):378-82.
2004: Uwe Walter; Christine Klein; Rüdiger Hilker; Reiner Benecke; Peter P Pramstaller; Dirk Dressler
Brain parenchyma sonography detects preclinical parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2004;19(12):1445-9.
2004: Katja Hedrich; Ana Djarmati; Nora Schäfer; Robert Hering; Claudia Wellenbrock; Peter H Weiss; Rüdiger Hilker; Peter Vieregge; Laurie J Ozelius; Peter Heutink; Vincenzo Bonifati; Eberhard Schwinger; Anthony E Lang; J Noth; Susan Bressman; Peter P Pramstaller; Olaf Riess; Christine Klein
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease.
Neurology 2004;62(3):389-94.
2004: Matthias Brand; Kirsten Labudda; Elke Kalbe; Rüdiger Hilker; David Emmans; Gerd Fuchs; Josef Kessler; Hans J Markowitsch
Decision-making impairments in patients with Parkinson's disease.
Behavioural neurology 2004;15(3-4):77-85.
2004: W-D Heiss; Rüdiger Hilker
The sensitivity of 18-fluorodopa positron emission tomography and magnetic resonance imaging in Parkinson's disease.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2004;11(1):5-12.
2004: Rüdiger Hilker; Jürgen Voges; Simon Weisenbach; Elke Kalbe; Lothar Burghaus; Mehran Ghaemi; Ralph Lehrke; Athanasios Koulousakis; Karl Herholz; Volker Sturm; Wolf-Dieter Heiss
Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(1):7-16.
2003: Mohammad Maarouf; Johannes Kuchta; Hrvoje Miletic; Heinrich Ebel; Volker Hesselmann; Rüdiger Hilker; Volker Sturm
Acute demyelination: diagnostic difficulties and the need for brain biopsy.
Acta neurochirurgica 2003;145(11):961-9; discussion 969.
2003: Rüdiger Hilker; Noushin Razai; Mehran Ghaemi; Simon Weisenbach; Jobst Rudolf; Brigitte Szelies; Wolf-Dieter Heiss
[18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's disease.
Clinical neurology and neurosurgery 2003;105(4):262-9.
2003: Dirk Zolldann; Carsten Poetter; Rüdiger Hilker; Michael Neveling; Birgit Waitschies; W Klein; Martina Nolden-Koch; Frank Block; Hans-Martin Wenchel; Sebastian W Lemmen
[Periodic surveillance of nosocomial infections in two neurology intensive care units. A valuable tool for quality management in intensive care].
Der Anaesthesist 2003;52(8):690-6.
2003: Andreas H Jacobs; Huongfeng Li; Alexandra Winkeler; Rüdiger Hilker; C Knoess; A Rüger; Norbert Galldiks; B Schaller; Jan Sobesky; Lutz W Kracht; P Monfared; Markus Klein; Stefan Vollmar; Bernd Bauer; R Wagner; Rudolf Graf; Klaus Wienhard; Karl Herholz; Wolf-Dieter Heiss
PET-based molecular imaging in neuroscience.
European journal of nuclear medicine and molecular imaging 2003;30(7):1051-65.
2003: Rüdiger Hilker; Carsten Poetter; Nahide Findeisen; Jan Sobesky; Andreas Jacobs; Michael Neveling; Wolf-Dieter Heiss
Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine.
Stroke; a journal of cerebral circulation 2003;34(4):975-81.
2003: Rüdiger Hilker; Jürgen Voges; Mehran Ghaemi; Ralph Lehrke; Jobst Rudolf; Athanasios Koulousakis; Karl Herholz; Klaus Wienhard; Volker Sturm; Wolf-Dieter Heiss
Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans.
Movement disorders : official journal of the Movement Disorder Society 2003;18(1):41-8.
2002: Mehran Ghaemi; Rüdiger Hilker; Jobst Rudolf; Jan Sobesky; W-D Heiss
Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging.
Journal of neurology, neurosurgery, and psychiatry 2002;73(5):517-23.
2002: Rüdiger Hilker; Jürgen Voges; Alexander Thiel; Mehran Ghaemi; Karl Herholz; Volker Sturm; Wolf-Dieter Heiss
Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(10):1257-64.
2002: Mehran Ghaemi; Jan Raethjen; Rüdiger Hilker; Jobst Rudolf; Jan Sobesky; Günther Deuschl; Wolf-Dieter Heiss
Monosymptomatic resting tremor and Parkinson's disease: a multitracer positron emission tomographic study.
Movement disorders : official journal of the Movement Disorder Society 2002;17(4):782-8.
2002: Andreas H Jacobs; A Winkler; Claus Dittmar; A Gossman; M Deckert; Lutz W Kracht; Alexander Thiel; Guido Garlip; Rüdiger Hilker; Jan Sobesky; Stefan Vollmar; Christiane Kummer; Rudolf Graf; Jürgen Voges; Klaus Wienhard; Karl Herholz; Wolf-Dieter Heiss
Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas.
Technology in cancer research & treatment 2002;1(3):187-204.
2002: Rüdiger Hilker; Christine Klein; Katja Hedrich; Laurie J Ozelius; Peter Vieregge; Karl Herholz; Peter P Pramstaller; Wolf-Dieter Heiss
The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans.
Neuroscience letters 2002;323(1):50-4.
2002: Andreas H Jacobs; Alexandra Winkeler; Claus Dittmar; Rüdiger Hilker; Wolf-Dieter Heiss
Prospects of molecular imaging in neurology.
Journal of cellular biochemistry. Supplement 2002;39():98-109.
2001: Rüdiger Hilker; M Schischniaschvili; Mehran Ghaemi; A Jacobs; Jobst Rudolf
Health related quality of life is improved by botulinum neurotoxin type A in long term treated patients with focal dystonia.
Journal of neurology, neurosurgery, and psychiatry 2001;71(2):193-9.
2001: Mehran Ghaemi; Jobst Rudolf; Rüdiger Hilker; Karl Herholz; Wolf-Dieter Heiss
Increased pineal Fdopa uptake is related to severity of Parkinson's disease--a PET study.
Journal of pineal research 2001;30(4):213-9.
2001: Rüdiger Hilker; Christine Klein; Mehran Ghaemi; Bernhard Kis; T Strotmann; Laurie J Ozelius; O Lenz; Peter Vieregge; Karl Herholz; Wolf-Dieter Heiss; Peter P Pramstaller
Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene.
Annals of neurology 2001;49(3):367-76.
2000: Jobst Rudolf; Martin Grond; Rüdiger Hilker; Mehran Ghaemi; A Jacobs; Wolf-Dieter Heiss
Relative sparing of the parietal cortex in cerebellar ataxia documented by positron emission tomography.
Clinical neurology and neurosurgery 2000;102(4):210-214.
2000: Rüdiger Hilker; A Thiel; Christoph Geisen; Jobst Rudolf
Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndrome.
Lupus 2000;9(4):311-6.
1999: Jobst Rudolf; Rüdiger Hilker; Klaus Terstegge; Ralf-Ingo Ernestus
Extended hemorrhagic infarction following isolated cortical venous thrombosis.
European neurology 1999;41(2):115-6.
1998: Rüdiger Mielke; Rüdiger Hilker; G Weber-Luxenburger; Josef Kessler; Wolf-Dieter Heiss
Early-onset cerebellar ataxia (EOCA) with retained reflexes: reduced cerebellar benzodiazepine-receptor binding, progressive metabolic and cognitive impairment.
Movement disorders : official journal of the Movement Disorder Society 1998;13(4):739-45.
1998: Rüdiger Hilker; Rüdiger Mielke; Frank Berthold; Rolf Schröder; Wolf-Dieter Heiss
[Mixed tumors of the pineal area. Diagnosis and therapy consisting of secreting germ cell tumor].
Der Nervenarzt 1998;69(6):519-24.