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Adrian Hill

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Pauline M van Diemen; Adrian V S Hill; Gavin K Paterson; Christine Rollier; Yuko Yamaguchi; David H Wyllie
Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge.
Julius Hafalla; Adrian V S Hill; Karolis Bauza; Johannes Friesen; Gloria Gonzalez-Aseguinolaza; Kai Matuschewski
Identification of Targets of CD8(+) T Cell Responses to Malaria Liver Stages by Genome-wide Epitope Profiling.
Anna L Goodman; Adrian V S Hill; Chris J Janse; David Llewellyn; Anne Moore; Richard J Pleass; Andrew R Williams; Karolis Bauza; Sumi Biswas; Simone C de Cassan; Matthew D J Dicks; Alexander D Douglas; Emily K Forbes; Blandine M Franke-Fayard; Sarah Gilbert; Simon J Draper
The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.

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2013: Pauline M van Diemen; Adrian V S Hill; Gavin K Paterson; Christine Rollier; Yuko Yamaguchi; David H Wyllie
Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge.
Pathogens and disease 2013;68(1):20-6.
2013: Julius Hafalla; Adrian V S Hill; Karolis Bauza; Johannes Friesen; Gloria Gonzalez-Aseguinolaza; Kai Matuschewski
Identification of Targets of CD8(+) T Cell Responses to Malaria Liver Stages by Genome-wide Epitope Profiling.
PLoS pathogens 2013;9(5):e1003303.
2013: Anna L Goodman; Adrian V S Hill; Chris J Janse; David Llewellyn; Anne Moore; Richard J Pleass; Andrew R Williams; Karolis Bauza; Sumi Biswas; Simone C de Cassan; Matthew D J Dicks; Alexander D Douglas; Emily K Forbes; Blandine M Franke-Fayard; Sarah Gilbert; Simon J Draper
The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.
Scientific reports 2013;3():1706.
2013: Sharon R Grossman; Adrian V S Hill; Elinor K. Karlsson; Eric S Lander; Daniel J Park; John L Rinn; Richard A Adegbola; Kristian G Andersen; Rameshwar N K Bamezai; Moran Cabili; Dustin Griesemer; Stephen F Schaffner; Ilya Shlyakhter; Shervin Tabrizi; Fredrik O Vannberg; Sarah Winnicki; Sunny H Wong; Angela Yen; Pardis C Sabeti
Identifying recent adaptations in large-scale genomic data.
Cell 2013;152(4):703-13.
2013: Sean C Elias; Katie Ewer; Fenella D Halstead; Adrian V S Hill; Susanne H Sheehy; Sumi Biswas; Carly M Bliss; Prateek Choudhary; Katharine A Collins; Christopher J A Duncan; Simon J Draper
Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1135-47.
2013: Amy C Boyd; Devanand Balkissoon; Connor Carson; Sarah C Gilbert; Adrian V S Hill; Marylene Y Peroval; Raul Ruiz-Hernandez; Karen Staines; Alison V Turner; Colin Butter
Towards a universal vaccine for avian influenza: protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus.
Vaccine 2013;31(4):670-5.
2013: Timothy J Powell; Sarah L Rowland-Jones; Tamara K Berthoud; Marie-Eve Blais; Sarah C Gilbert; Adrian V S Hill; Patrick J Lillie; Andrew J McMichael; Yanchun Peng; Tao Dong
Examination of Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with MVA-NP+M1 Vaccine.
PloS one 2013;8(5):e62778.
2013: George M Warimwe; Philip Bejon; Helen A Fletcher; Adrian V S Hill; Gathoni Kamuyu; Linda M Murungi; Vivek Naranbhai; George M Nyangweso; F H A Osier; Juliana Wambua; Kevin Marsh
The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children.
PloS one 2013;8(2):e57320.
2013: Rosalind Rowland; Iman Satti; Janet T Scott; Megan Whittaker; Nicola Williams; Joel Meyer; Angela M Minassian; Geraldine A O'Hara; Ansar A Pathan; Ian D Poulton; Hazel C Poyntz; Cynthia Bateman; Sarah C Gilbert; Matthew Hamill; Stephanie A Harris; Adrian V S Hill; Alison M Lawrie; Magali M L Matsumiya; Helen McShane
Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial.
Human vaccines & immunotherapeutics 2013;9(1):50-62.
2012: Ansar A Pathan; David W Porter; Ian D Poulton; Rosalind Rowland; Clare R Sander; Helen A Fletcher; Adrian V S Hill; Angela M Minassian; Helen McShane
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.
Vaccine 2012;30(38):5616-24.
2012: Christopher J A Duncan; Sarah C Gilbert; Matthew Hamill; Patrick J Lillie; Helen McShane; Joel Meyer; Geraldine A O'Hara; Ian D Poulton; Rosalind Rowland; Susanne H Sheehy; Laura Dinsmore; Hannah Donaldson; Adrian V S Hill
Incidental diagnosis in healthy clinical trial subjects.
Clinical and translational science 2012;5(4):348-50.
2012: Patrick J Lillie; Joel Meyer; Geraldine A O'Hara; Susanne H Sheehy; Christopher J A Duncan; Sarah C Gilbert; Adrian V S Hill
Distinguishing malaria and influenza: early clinical features in controlled human experimental infection studies.
Travel medicine and infectious disease 2012;10(4):192-6.
2012: Patrick J Lillie; Caitlin Mullarkey; John Oxford; Yanchun Peng; Timothy J Powell; Susanne H Sheehy; Alexandra J Spencer; Rob Lambkin Williams; Tamara K Berthoud; Marie-Eve Blais; Tao Dong; Christopher J A Duncan; Saul N Faust; Anthony Gilbert; Matthew Hamill; Tom Havelock; Adrian V S Hill; Teresa Lambe; Sarah C Gilbert
Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;55(1):19-25.
2012: Christopher J A Duncan; Adrian V S Hill; Ruth D Ellis
Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?
Human vaccines & immunotherapeutics 2012;8(6):706-14.
2012: Teresa Lambe; Caitlin E Mullarkey; Andrew J Pollard; Matthew D Snape; Alexandra J Spencer; Ben A V Thompson; Ly-Mee Yu; Richard D Antrobus; Jem Chalk; Philip de Whalley; Adrian V S Hill; Claire Jones; Simon Kerridge; Sarah C Gilbert
T-cell responses in children to internal influenza antigens, 1 year after immunization with pandemic H1N1 influenza vaccine, and response to revaccination with seasonal trivalent-inactivated influenza vaccine.
The Pediatric infectious disease journal 2012;31(6):e86-91.
2012: Sumi Biswas; Emily K Forbes; Sarah C Gilbert; Adrian V S Hill; Anthony A Holder; Alexandra J Spencer; Simon J Draper
Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):5041-53.
2012: Anto Vrdoljak; Conor O'Mahony; John B Carey; Abina M Crean; Simon J Draper; Adrian V S Hill; Marie G McGrath; Anne Moore
Coated microneedle arrays for transcutaneous delivery of live virus vaccines.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(1):34-42.
2012: Angela M Minassian; Ian D Poulton; Iman Satti; Adrian V S Hill; Joel Meyer; Helen McShane
A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin.
The Journal of infectious diseases 2012;205(7):1035-42.
2012: Thomas J Scriba; Erica Smit; Michele Tameris; Linda van der Merwe; Ashley Veldsman; Lebohang Makhethe; Katya Mauff; Helen McShane; Sizulu Moyo; Humphrey Mulenga; Nathaniel Brittain; Marwou de Kock; Hendrik Geldenhuys; Sebastian Gelderbloem; Willem A Hanekom; Mark Hatherill; Anthony Hawkridge; Adrian V S Hill; Elizabeth J Hughes; Gregory D Hussey; Esme Janse van Rensburg; Blessing Kadira; Alison Lawrie; Hassan Mahomed
A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults.
American journal of respiratory and critical care medicine 2012;185(7):769-78.
2012: Adrian V S Hill
Evolution, revolution and heresy in the genetics of infectious disease susceptibility.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1590):840-9.
2012: Stephen J Chapman; Adrian V S Hill
Human genetic susceptibility to infectious disease.
Nature reviews. Genetics 2012;13(3):175-88.
2012: Thorsten Thye; Reinout van Crevel; Esther van de Vosse; Fredrik O Vannberg; Alisjahbana Bachti; Yanina Balabanova; James Curtis; Francis Drobniewski; Christa Ehmen; John Gyapong; Adrian V S Hill; Philip C Hill; Rolf D Horstmann; Birgit Muntau; Sergey Nejentsev; Melanie Newport; Vladyslav Nikolayevskyy; Tom H M Ottenhoff; Ellis Owusu-Dabo; Gerd Ruge; Edhyana Sahiratmadja; Jürgen Sievertsen; Giorgio Sirugo; Christian G Meyer
Common variants at 11p13 are associated with susceptibility to tuberculosis.
Nature genetics 2012;44(3):257-9.
2012: Geraldine A O'Hara; Ian D Poulton; Arturo Reyes-Sandoval; Rosalind Rowland; Susanne H Sheehy; Loredana Siani; Stephen Todryk; Claire L Hutchings; Alison M Lawrie; Sarah Moyle; Alfredo Nicosia; Laura Andrews; Eleanor Berrie; Prudence Bird; Katharine A Collins; Stefano Colloca; Riccardo Cortese; Christopher J A Duncan; Nick J Edwards; Sean C Elias; Katie Ewer; Antonella Folgori; Sarah Gilbert; Anna L Goodman; Fenella D Halstead; Adrian V S Hill
Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector.
The Journal of infectious diseases 2012;205(5):772-81.
2012: Matthew G Cottingham; Sarah C Gilbert; Fionnadh Carroll; Stefano Colloca; Melissa Kapulu; Susan J Morris; Loredana Siani; Alison V Turner; Aisling M Vaughan; Adrian V S Hill
Preventing spontaneous genetic rearrangements in the transgene cassettes of adenovirus vectors.
Biotechnology and bioengineering 2012;109(3):719-28.
2012: Catrin E Moore; Daniel O'Connor; Kirsten P Perrett; Denise Brocklebank; Helen Fletcher; Andrew J Hall; Branwen J Hennig; Adrian V S Hill; J Claire Hoe; Sue J Lee; Shelley Segal; Matthew D Snape; Andrew J Pollard
Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine.
Clinical and vaccine immunology : CVI 2012;19(3):295-303.
2012: Adrian V S Hill
RTS,S/AS01 malaria vaccine in African children.
The New England journal of medicine 2012;366(8):764; author reply 765-6.
2012: Robin Antrobus; Tamara K Berthoud; Adrian V S Hill; Kristin Ladell; Teresa Lambe; Patrick J Lillie; James E McLaren; Anita Milicic; David A Price; Alexandra J Spencer; Sarah Gilbert
A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.
PloS one 2012;7(10):e48322.
2012: Emily K Forbes; Anna L Goodman; Adrian V S Hill; Fergal Hill; David Llewellyn; Carole A Long; Richard J Pleass; Sumi Biswas; Matthew G Cottingham; Simone C de Cassan; Simon J Draper
T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.
PloS one 2012;7(9):e44943.
2012: David H Wyllie; Xu Yaobo; Karen C Søgaard; Migena Bregu; Adrian V S Hill; Karen Holland; Endre Kiss-Toth
Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.
PloS one 2012;7(7):e42388.
2012: Matthew D J Dicks; Nick J Edwards; Sarah Gilbert; Adrian V S Hill; Alexandra J Spencer; Göran Wadell; Kalifa Bojang; Matthew G Cottingham
A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity.
PloS one 2012;7(7):e40385.
2012: Meta Roestenberg; Anja Scholzen; Andre J A M van der Ven; Christopher J A Duncan; Nick J Edwards; Judith E Epstein; Cornelus C Hermsen; Adrian V S Hill; Geraldine A O'Hara; Robert W Sauerwein
Comparison of clinical and parasitological data from controlled human malaria infection trials.
PloS one 2012;7(6):e38434.
2012: Anita Milicic; Yvonne Perrie; Arturo Reyes-Sandoval; Choon-Kit Tang; Jared Honeycutt; Randip Kaur; Adrian V S Hill
Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses.
PloS one 2012;7(3):e34255.
2012: Alexandra J Spencer; David H Wyllie; Migena Bregu; Matthew G Cottingham; Simon J Draper; Julie Furze; Sarah Gilbert; Fergal Hill; Jared D Honeycutt; Christine Rollier; Karen C Søgaard; Adrian V S Hill
Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates.
PloS one 2012;7(3):e33555.
2012: Susanne H Sheehy; Alexandra J Spencer; Eleanor Berrie; Sumi Biswas; Katharine A Collins; Stefano Colloca; Riccardo Cortese; Matthew D J Dicks; Tom Doherty; Christopher J A Duncan; Nick J Edwards; Sean C Elias; Katie Ewer; Katherine Gantlett; Sarah Gilbert; Fenella D Halstead; Adrian V S Hill; Alison M Lawrie; Carole A Long; Tabitha Mahungu; Kazutoyo Miura; Sarah Moyle; Alfredo Nicosia; Geraldine A O'Hara; Ian D Poulton; Simon J Draper
Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors.
PloS one 2012;7(2):e31208.
2011: Migena Bregu; Simon J Draper; Adrian V S Hill; Brian M Greenwood
Accelerating vaccine development and deployment: report of a Royal Society satellite meeting.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2841-9.
2011: Adrian V S Hill
Vaccines against malaria.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2806-14.
2011: Brian Greenwood; David Salisbury; Adrian V S Hill
Vaccines and global health.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2733-42.
2011: David W Porter; Ian Poulton; Eric Prieur; Rosalind Rowland; Robert E Sinden; Fiona M Thompson; Stephen Todryk; Jackie Williams; Laura Andrews; Tamara K Berthoud; Sumi Biswas; Simon Correa; Sarah Gilbert; Claire L Hutchings; Trudie Lang; Adrian V S Hill
A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine.
Vaccine 2011;29(43):7514-22.
2011: Emily K Forbes; Sarah Gilbert; Adrian V S Hill; Sumi Biswas; Katharine A Collins; Simon J Draper
Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3738-50.
2011: Simone C de Cassan; Alexander D Douglas; Virander S Chauhan; Chetan E Chitnis; Emily K Forbes; Sarah Gilbert; Puneet Gupta; Adrian V S Hill; Anita Milicic; Bijender Singh; Simon J Draper
The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2602-16.
2011: Arturo Reyes-Sandoval; Christine Rollier; David H Wyllie; Karolis Bauza; Emily K Forbes; Anita Milicic; Adrian V S Hill
CD8+ T effector memory cells protect against liver-stage malaria.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1347-57.
2011: Andrew J Pollard; Adrian V S Hill
Antibody repertoire: embracing diversity.
Science translational medicine 2011;3(93):93ps32.
2011: Martin O C Ota; Patrick K Owiafe; Olumuyiwa A Owolabi; Sarah Rowland-Jones; Nicola Williams; Richard A Adegbola; Nathaniel J Brittain; Simon A Donkor; Adrian V S Hill; Aderonke A Odutola; Helen McShane
Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants.
Science translational medicine 2011;3(88):88ra56.
2011: Thomas J Scriba; Michele Tameris; Nazma Mansoor; Erica Smit; Linda van der Merwe; Katya Mauff; Elizabeth J Hughes; Sizulu Moyo; Nathaniel Brittain; Alison Lawrie; Humphrey Mulenga; Marwou de Kock; Sebastian Gelderbloem; Ashley Veldsman; Mark Hatherill; Hendrik Geldenhuys; Adrian V S Hill; Gregory D Hussey; Hassan Mahomed; Willem A Hanekom; Helen McShane
Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants.
The Journal of infectious diseases 2011;203(12):1832-43.
2011: Fredrik O Vannberg; Stephen J Chapman; Adrian V S Hill
Human genetic susceptibility to intracellular pathogens.
Immunological reviews 2011;240(1):105-16.
2011: Fairfax Benjamin; Emma E Davenport; Seiko Makino; Adrian V S Hill; Fredrik O Vannberg; Julian C Knight
A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):3058-65.
2011: Julie George; Precious G Motshwene; Hui Wang; Andrew Kubarenko; Anna Rautanen; Tara C Mills; Adrian V S Hill; Nicholas J Gay; Alexander N R Weber
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
The Journal of biological chemistry 2011;286(2):1341-53.
2011: Anna M Checkley; Tanya Golubchik; Willem A Hanekom; Adrian V S Hill; Thomas J Scriba; David H Wyllie; Helen McShane
Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.
PloS one 2011;6(10):e26434.
2011: Kristin L Griffiths; Adrian V S Hill; Natalie E R Beveridge; Helen A Fletcher; Angela M Minassian; Ansar A Pathan; Clare R Sander; Helen McShane
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
PloS one 2011;6(8):e23463.
2011: John B Carey; Abina M Crean; Timothy Doody; Adrian V S Hill; Marie G McGrath; Conor O'Mahony; Frances E Pearson; Anto Vrdoljak; patrick walsh; Anne Moore
Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice.
PloS one 2011;6(7):e22442.
2011: Christopher J A Duncan; Nick J Edwards; Sean C Elias; Joan A Aebig; Charles F Anderson; Katharine A Collins; Alexander D Douglas; Simon J Draper; Katie Ewer; Michael P Fay; Sarah Gilbert; Fenella D Halstead; Adrian V S Hill; Angela Hunt-Cooke; Alison M Lawrie; Patrick J Lillie; Carole A Long; Laura B Martin; Kazutoyo Miura; David W Porter; Ian D Poulton; Kelly Rausch; Ros Rowland; Susanne H Sheehy; Fiona M Thompson; Yimin Wu; Daming Zhu; Ruth D Ellis
Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.
PloS one 2011;6(7):e22271.
2011: Sumi Biswas; Stefano Colloca; Matthew G Cottingham; Matthew D J Dicks; Sarah C Gilbert; Adrian V S Hill; Anthony A Holder; Carole A Long; Edmond J Remarque; Loredana Siani; Simon J Draper
Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.
PloS one 2011;6(6):e20977.
2011: Angela M Minassian; Edward O Ronan; Hazel Poyntz; Adrian V S Hill; Helen McShane
Preclinical development of an in vivo BCG challenge model for testing candidate TB vaccine efficacy.
PloS one 2011;6(5):e19840.
2011: James S Cavenaugh; Dorka Awi; Maimuna mendy; Adrian V S Hill; Hilton Whittle; Samuel J McConkey
Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection.
PloS one 2011;6(2):e14626.
2011: Tamara K Berthoud; Matthew Hamill; Patrick J Lillie; Lenias Hwenda; Katharine A Collins; Katie Ewer; Anita Milicic; Hazel C Poyntz; Teresa Lambe; Helen A Fletcher; Adrian V S Hill; Sarah Gilbert
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011;52(1):1-7.
2010: Stefania Capone; Arturo Reyes-Sandoval; Mariarosaria Naddeo; Loredana Siani; Virginia Ammendola; Christine S Rollier; Alfredo Nicosia; Stefano Colloca; Riccardo Cortese; Antonella Folgori; Adrian V S Hill
Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates.
Vaccine 2010;29(2):256-65.
2010: Simon J Draper; Sumi Biswas; Alexandra J Spencer; Edmond J Remarque; Stefania Capone; Mariarosaria Naddeo; Matthew D J Dicks; Bart W Faber; Simone C de Cassan; Antonella Folgori; Alfredo Nicosia; Sarah Gilbert; Adrian V S Hill
Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7583-95.
2010: Andrew Kubarenko; Satish Ranjan; Anna Rautanen; Tara C Mills; Sunny Wong; Fredrik Vannberg; Michael Neumaier; Isabelle Bekeredjian-Ding; Adrian V S Hill; Parviz Ahmad-Nejad; Alexander N R Weber
A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.
The Journal of biological chemistry 2010;285(47):36486-94.
2010: Alexander D Douglas; Simone C de Cassan; Matthew D J Dicks; Sarah Gilbert; Adrian V S Hill; Simon J Draper
Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1.
Vaccine 2010;28(44):7167-78.
2010: Jason Tye-Din; Jessica A Stewart; James A Dromey; Tim Beissbarth; David A van Heel; Arthur Tatham; Kate Henderson; Stuart I Mannering; Carmen Gianfrani; Derek P Jewell; Adrian V S Hill; James McCluskey; Jamie Rossjohn; Robert P Anderson
Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.
Science translational medicine 2010;2(41):41ra51.
2010: Simone C de Cassan; Ansar A Pathan; Clare R Sander; Angela Minassian; Rosalind Rowland; Adrian V S Hill; Helen McShane; Helen A Fletcher
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A.
Clinical and vaccine immunology : CVI 2010;17(7):1066-73.
2010: Sunny H Wong; Adrian V S Hill; Fredrik O Vannberg
Genomewide association study of leprosy.
The New England journal of medicine 2010;362(15):1446-7; author reply 1447-8.
2010: Sunny Hei Wong; Fredrik O Vannberg; Alexandra J Spencer; Louise van der Weyden; Adrian V S Hill; David H Wyllie
Comment on "CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node".
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4052-3.
2010: Julie George; Andriy V Kubarenko; Anna Rautanen; Tara C Mills; Elif Colak; Tore Kempf; Adrian V S Hill; Alexandra Nieters; Alexander N R Weber
MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):3025-32.
2010: Robert Alcock; Matthew G Cottingham; Christine Rollier; Julie Furze; Samodh D De Costa; Marian Hanlon; Alexandra J Spencer; Jared D Honeycutt; David H Wyllie; Sarah C Gilbert; Migena Bregu; Adrian V S Hill
Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass.
Science translational medicine 2010;2(19):19ra12.
2010: Fairfax Benjamin; Fredrik O Vannberg; Jayachandran Radhakrishnan; Hakon Hakonarson; Brendan J Keating; Adrian V S Hill; Julian C Knight
An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
Human molecular genetics 2010;19(4):720-30.
2010: Susanna Dunachie; Tamara Berthoud; Sheila Keating; Adrian V S Hill; Helen A Fletcher
MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy.
PloS one 2010;5(9):e12557.
2010: Stephen J Chapman; Fredrik O Vannberg; Chiea C Khor; Anna Rautanen; nick maskell; Christopher W H Davies; Catrin E Moore; Nicholas P Day; Derrick W Crook; Robert J O Davies; Adrian V S Hill
Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema.
BMC medical genetics 2010;11():5.
2010: Adrian V S Hill; Arturo Reyes-Sandoval; Geraldine O'Hara; Katie Ewer; Alison Lawrie; Anna Goodman; Alfredo Nicosia; Antonella Folgori; Stefano Colloca; Riccardo Cortese; Sarah Gilbert; Simon J Draper
Prime-boost vectored malaria vaccines: progress and prospects.
Human vaccines 2010;6(1):78-83.
2010: Thomas J Scriba; Michele Tameris; Nazma Mansoor; Erica Smit; Linda van der Merwe; Fatima Isaacs; Alana Keyser; Sizulu Moyo; Nathaniel Brittain; Alison Lawrie; Sebastian Gelderbloem; Ashley Veldsman; Mark Hatherill; Anthony Hawkridge; Adrian V S Hill; Gregory D Hussey; Hassan Mahomed; Helen McShane; Willem A Hanekom
Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.
European journal of immunology 2010;40(1):279-90.
2010: Arturo Reyes-Sandoval; Tamara Berthoud; Nicola Alder; Loredana Siani; Sarah Gilbert; Alfredo Nicosia; Stefano Colloca; Riccardo Cortese; Adrian V S Hill
Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses.
Infection and immunity 2010;78(1):145-53.
2009: Tamara K Berthoud; Helen Fletcher; David Porter; Fiona Thompson; Adrian V S Hill; Stephen Todryk
Comparing human T cell and NK cell responses in viral-based malaria vaccine trials.
Vaccine 2009;28(1):21-7.
2009: Stephen Todryk; Michael Walther; Philip Bejon; Claire L Hutchings; Fiona M Thompson; Britta C Urban; David W Porter; Adrian V S Hill
Multiple functions of human T cells generated by experimental malaria challenge.
European journal of immunology 2009;39(11):3042-51.
2009: Vasee S Moorthy; C Diggs; S Ferro; M F Good; S Herrera; Adrian V S Hill; E B Imoukhuede; S Kumar; C Loucq; Kevin Marsh; C F Ockenhouse; T L Richie; R W Sauerwein
Report of a consultation on the optimization of clinical challenge trials for evaluation of candidate blood stage malaria vaccines, 18-19 March 2009, Bethesda, MD, USA.
Vaccine 2009;27(42):5719-25.
2009: Karen Colbjørn Larsen; Alexandra J Spencer; Anna L Goodman; Ashley Gilchrist; Julie Furze; Christine Rollier; Endre Kiss-Toth; Sarah Gilbert; Migena Bregu; Elizabeth J Soilleux; Adrian V S Hill; David H Wyllie
Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines.
Vaccine 2009;27(41):5589-98.
2009: Stephen Todryk; Ansar A Pathan; Sheila Keating; David W Porter; Tamara Berthoud; Fiona Thompson; Paul Klenerman; Adrian V S Hill
The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming.
Immunology 2009;128(1):83-91.
2009: Emily J Lyons; Angela J Frodsham; Lyna Zhang; Adrian V S Hill; William Amos
Consanguinity and susceptibility to infectious diseases in humans.
Biology letters 2009;5(4):574-6.
2009: Martin Vordermeier; Bernardo Villarreal-Ramos; Paul J Cockle; Martin McAulay; Shelley G Rhodes; Tyler Thacker; Sarah Gilbert; Helen McShane; Adrian V S Hill; Zhou Xing; R Glyn Hewinson
Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis.
Infection and immunity 2009;77(8):3364-73.
2009: Clare R Sander; Ansar A Pathan; Natalie E R Beveridge; Ian Poulton; Angela Minassian; Nicola Alder; Johan Van Wijgerden; Adrian V S Hill; Fergus V Gleeson; Robert J O Davies; Geoffrey Pasvol; Helen McShane
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals.
American journal of respiratory and critical care medicine 2009;179(8):724-33.
2009: Adrian V S Hill; Martin Shirley; Brian M Greenwood
Jenner reborn: a new vaccine institute.
Lancet 2009;373(9662):445-6.
2009: Elma Z Tchilian; Christiane Desel; Emily K Forbes; Silke Bandermann; Clare R Sander; Adrian V S Hill; Helen McShane; Stefan H E Kaufmann
Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis.
Infection and immunity 2009;77(2):622-31.
2009: Simon J Draper; Anna L Goodman; Sumi Biswas; Emily K Forbes; Anne Moore; Sarah Gilbert; Adrian V S Hill
Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria.
Cell host & microbe 2009;5(1):95-105.
2009: Jedidah Mwacharo; Susanna Dunachie; Oscar Kai; Adrian V S Hill; Philip Bejon; Helen A Fletcher
Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine.
PloS one 2009;4(12):e8434.
2009: Kathryn T Whelan; Ansar A Pathan; Clare R Sander; Helen A Fletcher; Ian Poulton; Nicola C Alder; Adrian V S Hill; Helen McShane
Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.
PloS one 2009;4(6):e5934.
2009: Emily J Lyons; William Amos; James A Berkley; Isaiah Mwangi; Mohammed Shafi; Thomas N Williams; Charles Newton; Norbert Peshu; Kevin Marsh; J Anthony G Scott; Adrian V S Hill
Homozygosity and risk of childhood death due to invasive bacterial disease.
BMC medical genetics 2009;10():55.
2009: Frank A W Verreck; Richard A W Vervenne; Ivanela Kondova; Klaas W van Kralingen; Edmond J Remarque; Gerco Braskamp; Nicole M van der Werff; Ariena Kersbergen; Tom H M Ottenhoff; Peter J Heidt; Sarah C Gilbert; Brigitte Gicquel; Adrian V S Hill; Carlos Martin; Helen McShane; Alan W Thomas
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.
PloS one 2009;4(4):e5264.
2008: Natalie E R Beveridge; Helen A Fletcher; Jane Hughes; Ansar A Pathan; Thomas J Scriba; Angela Minassian; Clare R Sander; Kathryn T Whelan; Hazel M Dockrell; Adrian V S Hill; Willem A Hanekom; Helen McShane
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.
Tuberculosis (Edinburgh, Scotland) 2008;88(6):631-40.
2008: Emily K Forbes; Clare Sander; Edward O Ronan; Helen McShane; Adrian V S Hill; Peter C L Beverley; Elma Z Tchilian
Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4955-64.
2008: Helen A Fletcher; Ansar A Pathan; Tamara K Berthoud; Susanna Dunachie; Kathryn T Whelan; Nicola C Alder; Clare R Sander; Adrian V S Hill; Helen McShane
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.
Vaccine 2008;26(41):5269-75.
2008: Tony Hawkridge; Thomas J Scriba; Sebastian Gelderbloem; Erica Smit; Michele Tameris; Sizulu Moyo; Trudie Lang; Ashley Veldsman; Mark Hatherill; Helen A Fletcher; Hassan Mahomed; Adrian V S Hill; Willem A Hanekom; Gregory D Hussey; Linda van der Merwe; Helen McShane
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa.
The Journal of infectious diseases 2008;198(4):544-52.
2008: Simon J Draper; Anne Moore; Anna L Goodman; Carole A Long; Anthony A Holder; Sarah Gilbert; Fergal Hill; Adrian V S Hill
Effective induction of high-titer antibodies by viral vector vaccines.
Nature medicine 2008;14(8):819-21.
2008: Jagadeesh Bayry; Elma Z Tchilian; Matthew N Davies; Emily K Forbes; Simon J Draper; Srini V Kaveri; Adrian V S Hill; Michel D Kazatchkine; Peter C L Beverley; Darren R Flower; David F Tough
In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10221-6.
2008: Graham S Cooke; Sarah J Campbell; Steve Bennett; Christian Lienhardt; Keith P W J McAdam; Giorgio Sirugo; Oumou Y Sow; Per Gustafson; Frank Mwangulu; Paul van Helden; Paul Fine; Eileen G Hoal; Adrian V S Hill
Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.
American journal of respiratory and critical care medicine 2008;178(2):203-7.
2008: Frances Sanderson; Laura Andrews; Alexander D Douglas; Angela Hunt-Cooke; Philip Bejon; Adrian V S Hill
Blood-stage challenge for malaria vaccine efficacy trials: a pilot study with discussion of safety and potential value.
The American journal of tropical medicine and hygiene 2008;78(6):878-83.
2008: B J Hennig; A E Fry; K Hirai; H Tahara; A Tamori; M Moller; J Hopkin; Adrian V S Hill; W Bodmer; P Beverley; E Tchilian
PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.
Tissue antigens 2008;71(5):458-63.
2008: Arturo Reyes-Sandoval; Saranya Sridhar; Tamara Berthoud; Anne Moore; John T Harty; Sarah Gilbert; Guangping Gao; Hildegund C J Ertl; James C Wilson; Adrian V S Hill
Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.
European journal of immunology 2008;38(3):732-41.
2008: Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; David J Jeffries; Simon A Donkor; Helen A Fletcher; Abdulrahman Hammond; Christian Lienhardt; Richard A Adegbola; Helen McShane; Adrian V S Hill
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.
PloS one 2008;3(8):e2921.
2008: Stephen Todryk; Philip Bejon; Tabitha Mwangi; Magdalena Plebanski; Britta Urban; Kevin Marsh; Adrian V S Hill; Katie L Flanagan
Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans.
PloS one 2008;3(4):e2027.
2008: Matthew G Cottingham; Rikke F Andersen; Alexandra J Spencer; Saroj Saurya; Julie Furze; Adrian V S Hill; Sarah Gilbert
Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA).
PloS one 2008;3(2):e1638.
2008: Philip Bejon; Tabitha W Mwangi; Brett Lowe; Norbert Peshu; Adrian V S Hill; Kevin Marsh
Helminth infection and eosinophilia and the risk of Plasmodium falciparum malaria in 1- to 6-year-old children in a malaria endemic area.
PLoS neglected tropical diseases 2008;2(1):e164.
2008: Fiona M Thompson; David W Porter; Shinji L Okitsu; Nicole Westerfeld; Denise Vogel; Stephen Todryk; Ian Poulton; Simon Correa; Claire L Hutchings; Tamara Berthoud; Susanna Dunachie; Laura Andrews; Jack L Williams; Robert Sinden; Sarah Gilbert; Gerd Pluschke; Rinaldo Zurbriggen; Adrian V S Hill
Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial.
PloS one 2008;3(1):e1493.
2008: Fredrik O Vannberg; Stephen J Chapman; Chiea C Khor; Kerrie Tosh; Sian Floyd; Dolly Jackson-Sillah; Amelia C Crampin; Lifted Sichali; Boubacar Bah; Per Gustafson; Peter Aaby; Keith P W J McAdam; Oumou Bah-Sow; Christian Lienhardt; Giorgio Sirugo; Paul Fine; Adrian V S Hill
CD209 genetic polymorphism and tuberculosis disease.
PloS one 2008;3(1):e1388.
2007: Claire L Hutchings; Ashley J Birkett; Anne Moore; Adrian V S Hill
Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge.
Infection and immunity 2007;75(12):5819-26.
2007: Denise M O'Sullivan; C Sander; RJ Shorten; Stephen H Gillespie; Adrian V S Hill; Timothy D McHugh; H McShane; Elma Z Tchilian
Evaluation of liquid culture for quantitation of Mycobacterium tuberculosis in murine models.
Vaccine 2007;25(49):8203-5.
2007: Philip Bejon; Tabitha W Mwangi; Brett Lowe; Norbert Peshu; Adrian V S Hill; Kevin Marsh
Clearing asymptomatic parasitaemia increases the specificity of the definition of mild febrile malaria.
Vaccine 2007;25(48):8198-202.
2007: Natalie E R Beveridge; David A Price; Joseph P Casazza; Ansar A Pathan; Clare R Sander; Tedi E Asher; David R Ambrozak; Melissa L Precopio; Phillip Scheinberg; Nicola C Alder; Mario Roederer; Richard A Koup; Daniel C Douek; Adrian V S Hill; Helen McShane
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
European journal of immunology 2007;37(11):3089-100.
2007: Chiea C Khor; Fredrik O Vannberg; Stephen J Chapman; Andrew J Walley; Christophe Aucan; Hsin Loke; Nicholas J White; T Peto; L K Khor; Dominic Kwiatkowski; N Day; A Scott; James A Berkley; K Marsh; Norbert Peshu; Kathryn Maitland; Thomas N Williams; Adrian V S Hill
Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus.
Genes and immunity 2007;8(7):570-6.
2007: Philip Bejon; Jedidah Mwacharo; Oscar Kai; Stephen Todryk; Sheila Keating; Brett Lowe; Trudie Lang; Tabitha W Mwangi; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):4193-201.
2007: Stephen J Chapman; Chiea C Khor; Fredrik O Vannberg; Angela J Frodsham; Andrew J Walley; nick maskell; Christopher W H Davies; Shelley Segal; Catrin E Moore; Stephen H Gillespie; Paul Denny; Nicholas P J Day; Derrick W Crook; Robert J O Davies; Adrian V S Hill
IkappaB genetic polymorphisms and invasive pneumococcal disease.
American journal of respiratory and critical care medicine 2007;176(2):181-7.
2007: Stephen Todryk; Adrian V S Hill
Malaria vaccines: the stage we are at.
Nature reviews. Microbiology 2007;5(7):487-9.
2007: T Blake Ball; Hezhao Ji; Joshua Kimani; Paul J McLaren; Crystal Marlin; Adrian V S Hill; Francis A Plummer
Polymorphisms in IRF-1 associated with resistance to HIV-1 infection in highly exposed uninfected Kenyan sex workers.
AIDS (London, England) 2007;21(9):1091-101.
2007: Stephen J Chapman; Fredrik O Vannberg; Chiea C Khor; Shelley Segal; Catrin E Moore; Kyle Knox; Nicholas P J Day; Robert J O Davies; Derrick W Crook; Adrian V S Hill
Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease.
Molecular immunology 2007;44(12):3267-70.
2007: Shengqiang Li; Emily Locke; Joseph Bruder; David Clarke; Denise L Doolan; Menzo J E Havenga; Adrian V S Hill; Peter Liljestrom; Thomas P Monath; Hussein Y Naim; Christian Ockenhouse; De-chu C Tang; Kent R Van Kampen; Jean-Francois Viret; Fidel Zavala; Filip Dubovsky
Viral vectors for malaria vaccine development.
Vaccine 2007;25(14):2567-74.
2007: Egeruan B Imoukhuede; Laura Andrews; Paul Milligan; Tamara Berthoud; Kalifa Bojang; Davis Nwakanma; Jamila Ismaili; Caroline Buckee; Fanta Njie; Saikou Keita; Maimuna Sowe; Trudie Lang; Sarah Gilbert; Brian M Greenwood; Adrian V S Hill
Low-level malaria infections detected by a sensitive polymerase chain reaction assay and use of this technique in the evaluation of malaria vaccines in an endemic area.
The American journal of tropical medicine and hygiene 2007;76(3):486-93.
2007: Ansar A Pathan; Clare R Sander; Helen A Fletcher; Ian Poulton; Nicola C Alder; Natalie E R Beveridge; Kathryn T Whelan; Adrian V S Hill; Helen McShane
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials.
PloS one 2007;2(10):e1052.
2007: Philip Bejon; Edna Ogada; Tabitha W Mwangi; Paul Milligan; Trudie Lang; Greg Fegan; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.
PloS one 2007;2(8):e707.
2006: Philip Bejon; Sheila Keating; Jedidah Mwacharo; Oscar Kai; Susanna Dunachie; Michael Walther; Tamara Berthoud; Trudie Lang; Judy Epstein; Daniel J Carucci; Philippe Moris; Joe Cohen; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.
Infection and immunity 2006;74(11):6331-8.
2006: Egeruan B Imoukhuede; Tamara Berthoud; Paul Milligan; Kalifa Bojang; Jamila Ismaili; Sheila Keating; Davis Nwakanma; Saikou Keita; F Njie; Maimuna Sowe; Stephen Todryk; Stephen M Laidlaw; Michael A Skinner; Trudie Lang; Sarah Gilbert; Brian M Greenwood; Adrian V S Hill
Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.
Vaccine 2006;24(42-43):6526-33.
2006: Michael Walther; John Woodruff; Fanny Edele; David Jeffries; Jon Eric Tongren; Elizabeth King; Laura Andrews; Philip Bejon; Sarah Gilbert; J Brian de Souza; Robert Sinden; Adrian V S Hill; Eleanor M Riley
Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5736-45.
2006: Susanna Dunachie; Michael Walther; Judith E Epstein; Sheila Keating; Tamara Berthoud; Laura Andrews; Rikke F Andersen; Philip Bejon; Nilu Goonetilleke; Ian Poulton; Daniel P Webster; Geoffrey Butcher; Kate Watkins; Robert E Sinden; G L Levine; Thomas L Richie; Joerg Schneider; D Kaslow; Sarah Gilbert; Daniel J Carucci; Adrian V S Hill
A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.
Infection and immunity 2006;74(10):5933-42.
2006: Kerrie Tosh; Muthuswamy Ravikumar; Jordana Tzenova Bell; Sarah Meisner; Adrian V S Hill; Ramasamy Pitchappan
Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.
Human molecular genetics 2006;15(19):2880-7.
2006: Graham S Cooke; Kerrie Tosh; Patricia A Ramaley; Pontiano Kaleebu; Joanna Zhuang; Jessica Nakiyingi; Christine Watera; Charles F Gilks; French Neil; James A G Whitworth; Adrian V S Hill
A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.
The Journal of infectious diseases 2006;194(5):666-9.
2006: Hannah B Ibanga; Roger H Brookes; Philip C Hill; Patrick K Owiafe; Helen A Fletcher; Christian Lienhardt; Adrian V S Hill; Richard A Adegbola; Helen McShane
Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design.
The Lancet infectious diseases 2006;6(8):522-8.
2006: Philip Bejon; Oscar Kai; Jedidah Mwacharo; Sheila Keating; Trudie Lang; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area.
European journal of immunology 2006;36(8):2264-72.
2006: Graham S Cooke; Sarah J Campbell; Jackson Sillah; Per Gustafson; Boubacar Bah; Giorgio Sirugo; Steve Bennett; Keith P W J McAdam; Oumou Y Sow; Christian Lienhardt; Adrian V S Hill
Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.
American journal of respiratory and critical care medicine 2006;174(3):339-43.
2006: Kerrie Tosh; Sarah J Campbell; Katherine Fielding; Jackson Sillah; Boubacar Bah; Per Gustafson; Kebba Manneh; Ida Maria Lisse; Giorgio Sirugo; Steve Bennett; Peter Aaby; Keith P W J McAdam; Oumou Bah-Sow; Christian Lienhardt; Igor Kramnik; Adrian V S Hill
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10364-8.
2006: Angela J Frodsham; Lyna Zhang; Uga Dumpis; Nor Azizah Mohd Taib; Steve Best; Andrew Durham; B J W Hennig; Simon Hellier; Susanne Knapp; Mark Wright; Maria Chiaramonte; John I Bell; Mary Graves; Hilton C Whittle; Howard Thomas; Mark Thursz; Adrian V S Hill
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9148-53.
2006: Philip Bejon; Jedidah Mwacharo; Oscar Kai; Stephen Todryk; Sheila Keating; Trudie Lang; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area.
Vaccine 2006;24(22):4709-15.
2006: Sarah Gilbert; Vasee S Moorthy; Laura Andrews; Ansar A Pathan; Samuel J McConkey; Jenni M Vuola; Sheila Keating; Tamara Berthoud; Daniel Webster; Helen McShane; Adrian V S Hill
Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis.
Vaccine 2006;24(21):4554-61.
2006: Stephen J Chapman; Chiea C Khor; Fredrik O Vannberg; nick maskell; Christopher W H Davies; Emma Hedley; Shelley Segal; Catrin E Moore; Kyle Knox; Nicholas P J Day; Stephen H Gillespie; Derrick W Crook; Robert J O Davies; Adrian V S Hill
PTPN22 and invasive bacterial disease.
Nature genetics 2006;38(5):499-500.
2006: Michael Walther; Fiona M Thompson; Susanna Dunachie; Sheila Keating; Stephen Todryk; Tamara Berthoud; Laura Andrews; Rikke F Andersen; Anne Moore; Sarah Gilbert; Ian Poulton; Filip Dubovsky; Eveline Tierney; Simon Correa; Angela Huntcooke; Geoffrey Butcher; Jack Williams; Robert E Sinden; Adrian V S Hill
Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein.
Infection and immunity 2006;74(5):2706-16.
2006: Edwin A M Lee; Katie L Flanagan; Gabriela Minigo; William H H Reece; Robin Bailey; Margaret Pinder; Adrian V S Hill; Magdalena Plebanski
Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming.
European journal of immunology 2006;36(5):1168-78.
2006: Philip Bejon; Norbert Peshu; Sarah Gilbert; Brett S Lowe; Catherine S Molyneux; John Forsdyke; Trudie Lang; Adrian V S Hill; Kevin Marsh
Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(8):1102-10.
2006: Daniel P Webster; Susanna Dunachie; Samuel J McConkey; Ian Poulton; Anne Moore; Michael Walther; Stephen M Laidlaw; T E A Peto; Michael A Skinner; Sarah Gilbert; Adrian V S Hill
Safety of recombinant fowlpox strain FP9 and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
Vaccine 2006;24(15):3026-34.
2006: Susanna Dunachie; Michael Walther; Jenni M Vuola; Daniel P Webster; Sheila Keating; Tamara Berthoud; Laura Andrews; Philip Bejon; Ian Poulton; Geoffrey Butcher; Kate Watkins; Robert E Sinden; Amanda Leach; Philippe Moris; Nadia Tornieporth; Joerg Schneider; Filip Dubovsky; Eveline Tierney; Jack Williams; Donald Heppner; Sarah Gilbert; Joe Cohen; Adrian V S Hill
A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.
Vaccine 2006;24(15):2850-9.
2006: Robert P Anderson; David A van Heel; Jason Tye-Din; D P Jewell; Adrian V S Hill
Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease.
Gut 2006;55(4):485-91.
2006: Katie L Flanagan; Magdalena Plebanski; Kennedy Odhiambo; Eric G Sheu; Tabitha W Mwangi; Colin Gelder; Keith Hart; Moses Kortok; Brett Lowe; Kathryn J H Robson; Kevin Marsh; Adrian V S Hill
Cellular reactivity to the p. Falciparum protein trap in adult kenyans: novel epitopes, complex cytokine patterns, and the impact of natural antigenic variation.
The American journal of tropical medicine and hygiene 2006;74(3):367-75.
2006: Adrian V S Hill
Aspects of genetic susceptibility to human infectious diseases.
Annual review of genetics 2006;40():469-86.
2006: Philip Bejon; Laura Andrews; Angela Hunt-Cooke; Frances Sanderson; Sarah Gilbert; Adrian V S Hill
Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density.
Malaria journal 2006;5():104.
2006: Philip Bejon; Jedidah Mwacharo; Oscar Kai; Tabitha W Mwangi; Paul Milligan; Stephen Todryk; Sheila Keating; Trudie Lang; Brett Lowe; Caroline Gikonyo; Catherine S Molyneux; Greg Fegan; Sarah Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.
PLoS clinical trials 2006;1(6):e29.
2006: Adrian V S Hill
Pre-erythrocytic malaria vaccines: towards greater efficacy.
Nature reviews. Immunology 2006;6(1):21-32.
2005: T Lang; Adrian V S Hill; H McShane; R Shah; Adrian Towse; C Pritchard; M Garau
New TB vaccine granted orphan drug status.
BMJ (Clinical research ed.) 2005;331(7530):1476.
2005: Anne Moore; Awen Gallimore; Simon J Draper; Katherine R Watkins; Sarah Gilbert; Adrian V S Hill
Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7264-73.
2005: Sheila Keating; Philip Bejon; Tamara Berthoud; Jenni M Vuola; Stephen Todryk; Daniel P Webster; Susanna Dunachie; Vasee S Moorthy; Samuel J McConkey; Sarah Gilbert; Adrian V S Hill
Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5675-80.
2005: Michael Walther; Jon Eric Tongren; Laura Andrews; Daniel Korbel; Elizabeth King; Helen Fletcher; Rikke F Andersen; Philip Bejon; Fiona Thompson; Susanna Dunachie; Fanny Edele; J Brian de Souza; Robert E Sinden; Sarah Gilbert; Eleanor M Riley; Adrian V S Hill
Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection.
Immunity 2005;23(3):287-96.
2005: Robert P Anderson; David A van Heel; Jason Tye-Din; M C N M Barnardo; M Salio; D P Jewell; Adrian V S Hill
T cells in peripheral blood after gluten challenge in coeliac disease.
Gut 2005;54(9):1217-23.
2005: Laura Andrews; Rikke F Andersen; Daniel Webster; Susanna Dunachie; R Michael Walther; Philip Bejon; Angela Hunt-Cooke; Gillian Bergson; Frances Sanderson; Adrian V S Hill; Sarah Gilbert
Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials.
The American journal of tropical medicine and hygiene 2005;73(1):191-8.
2005: Claire L Hutchings; Sarah Gilbert; Adrian V S Hill; Anne Moore
Novel protein and poxvirus-based vaccine combinations for simultaneous induction of humoral and cell-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):599-606.
2005: Andrew Godkin; Miles Davenport; Adrian V S Hill
Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness.
Hepatology (Baltimore, Md.) 2005;41(6):1383-90.
2005: A Williams; Nilu Goonetilleke; Helen McShane; Simon O Clark; Graham Hatch; Sarah Gilbert; Adrian V S Hill
Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs.
Infection and immunity 2005;73(6):3814-6.
2005: Magdalena Plebanski; Carolyn M Hannan; Shahriar Behboudi; Katie L Flanagan; Vasso Apostolopoulos; Robert E Sinden; Adrian V S Hill
Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses.
Immunology and cell biology 2005;83(3):307-12.
2005: Daniel P Webster; Susanna Dunachie; Jenni M Vuola; Tamara Berthoud; Sheila Keating; Stephen M Laidlaw; Samuel J McConkey; Ian Poulton; Laura Andrews; Rikke F Andersen; Philip Bejon; Geoffrey Butcher; Robert Sinden; Michael A Skinner; Sarah Gilbert; Adrian V S Hill
Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4836-41.
2005: Philip Bejon; Laura Andrews; Rikke F Andersen; Susanna Dunachie; Daniel Webster; Michael Walther; Sarah Gilbert; T E A Peto; Adrian V S Hill
Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites.
The Journal of infectious diseases 2005;191(4):619-26.
2005: Karen Young; Angela J Frodsham; Ogobara K Doumbo; Sunetra Gupta; Amagana Dolo; Jiang Ting Hu; Kathryn J H Robson; Andrea Crisanti; Adrian V S Hill; Sarah Gilbert
Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations.
Infection and immunity 2005;73(2):953-5.
2005: Simone Korten; Richard J Anderson; Carolyn M Hannan; Eric G Sheu; Robert Sinden; Stephan D Gadola; Masaru Taniguchi; Adrian V S Hill
Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the liver after poxvirus vaccination of mice.
Infection and immunity 2005;73(2):849-58.
2005: Michael Walther; Susanna Dunachie; Sheila Keating; Jenni M Vuola; Tamara Berthoud; Annette Schmidt; Carolin Maier; Laura Andrews; Rikke F Andersen; Sarah Gilbert; Ian Poulton; Daniel Webster; Filip Dubovsky; Eveline Tierney; Pramod Sarpotdar; Simon Correa; Angela Huntcooke; Geoffrey Butcher; Jack Williams; Robert E Sinden; george thornton; Adrian V S Hill
Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.
Vaccine 2005;23(7):857-64.
2005: Helen McShane; Ansar A Pathan; Clare R Sander; Nilu Goonetilleke; Helen A Fletcher; Adrian V S Hill
Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):47-52.
2005: Jenni M Vuola; Sheila Keating; Daniel P Webster; Tamara Berthoud; Susanna Dunachie; Sarah Gilbert; Adrian V S Hill
Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):449-55.
2004: Amanda Wiart; Annette Jepson; Winston Banya; Steve Bennett; Hilton Whittle; Nicholas G Martin; Adrian V S Hill
Quantitative association tests of immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa.
Twin research : the official journal of the International Society for Twin Studies 2004;7(6):578-88.
2004: Catrin E Moore; Shelley Segal; Anthony R Berendt; Adrian V S Hill; Nicholas P J Day
Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.
Clinical and diagnostic laboratory immunology 2004;11(6):1194-7.
2004: Helen McShane; Ansar A Pathan; Clare R Sander; Sheila Keating; Sarah Gilbert; Kris Huygen; Helen A Fletcher; Adrian V S Hill
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
Nature medicine 2004;10(11):1240-4.
2004: Liza Bornman; Sarah J Campbell; Katherine Fielding; Boubacar Bah; Jackson Sillah; Per Gustafson; Kebba Manneh; Ida Maria Lisse; Angela Allen; Giorgio Sirugo; Aissatou Sylla; Peter Aaby; Keith P W J McAdam; Oumou Bah-Sow; Steve Bennett; Christian Lienhardt; Adrian V S Hill
Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
The Journal of infectious diseases 2004;190(9):1631-41.
2004: Shahriar Behboudi; Anne Moore; Sarah Gilbert; Claire L Nicoll; Adrian V S Hill
Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction.
Vaccine 2004;22(31-32):4326-31.
2004: Angela J Frodsham; Adrian V S Hill
Genetics of infectious diseases.
Human molecular genetics 2004;13 Spec No 2():R187-94.
2004: Jodene Fitness; Sian Floyd; David K Warndorff; Lifted Sichali; Simon Malema; Amelia C Crampin; Paul E M Fine; Adrian V S Hill
Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi.
The American journal of tropical medicine and hygiene 2004;71(3):341-9.
2004: Jodene Fitness; Sian Floyd; David K Warndorff; Lifted Sichali; Lorren Mwaungulu; Amelia C Crampin; Paul E M Fine; Adrian V S Hill
Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.
The American journal of tropical medicine and hygiene 2004;71(3):330-40.
2004: W Ripley Ballou; Myriam Arevalo-Herrera; Daniel J Carucci; Thomas L Richie; Giampietro Corradin; Carter L Diggs; Pierre Druilhe; Birgitte K Giersing; Allan Saul; Donald Heppner; Kent Kester; David Lanar; Jeff Lyon; Adrian V S Hill; Weiqing Pan; Joe D Cohen
Update on the clinical development of candidate malaria vaccines.
The American journal of tropical medicine and hygiene 2004;71(2 Suppl):239-47.
2004: Martin Vordermeier; Shelley G Rhodes; Gillian Dean; Nilu Goonetilleke; Kris Huygen; Adrian V S Hill; R Glyn Hewinson; Sarah Gilbert
Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin.
Immunology 2004;112(3):461-70.
2004: Vasee S Moorthy; Egeruan B Imoukhuede; Sheila Keating; Margaret Pinder; Daniel Webster; Michael A Skinner; Sarah Gilbert; Gijs Walraven; Adrian V S Hill
Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men.
The Journal of infectious diseases 2004;189(12):2213-9.
2004: Anne Moore; Adrian V S Hill
Progress in DNA-based heterologous prime-boost immunization strategies for malaria.
Immunological reviews 2004;199():126-43.
2004: Tara Stanton; Sally Boxall; Andrea Bennett; Pontiano Kaleebu; Christine Watera; Jimmy Whitworth; French Neil; Ritu Dawes; Adrian V S Hill; Walter Bodmer; Peter C L Beverley; Elma Z Tchilian
CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans.
Immunogenetics 2004;56(2):107-10.
2004: chris wallace; Jodene Fitness; B J W Hennig; Lifted Sichali; Lorren Mwaungulu; Jörg M Pönnighaus; David K Warndorff; David Clayton; Paul E M Fine; Adrian V S Hill
Linkage analysis of susceptibility to leprosy type using an IBD regression method.
Genes and immunity 2004;5(3):221-5.
2004: Leland J Yee; Susanne Knapp; D Burgner; B J W Hennig; Angela J Frodsham; Mark Wright; Howard Thomas; Adrian V S Hill; Mark Thursz
Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection.
Genes and immunity 2004;5(3):183-7.
2004: Graham S Cooke; Sarah J Campbell; Katherine Fielding; Jackson Sillah; Kebba Manneh; Giorgio Sirugo; Steve Bennett; Keith P W J McAdam; Christian Lienhardt; Adrian V S Hill
Interleukin-8 polymorphism is not associated with pulmonary tuberculosis in the gambia.
The Journal of infectious diseases 2004;189(8):1545-6; author reply 1546.
2004: William H H Reece; Margaret Pinder; Philip K Gothard; Paul Milligan; Kalifa Bojang; Tom Doherty; Magdalena Plebanski; Peter Akinwunmi; Simone Everaere; Katherine R Watkins; Gerald Voss; Nadia Tornieporth; Ali Alloueche; Brian M Greenwood; Kent Kester; Keith P W J McAdam; Joe Cohen; Adrian V S Hill
A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.
Nature medicine 2004;10(4):406-10.
2004: Shahriar Behboudi; Anne Moore; Adrian V S Hill
Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells.
Cellular immunology 2004;228(1):15-9.
2004: Richard J Anderson; Carolyn M Hannan; Sarah Gilbert; Stephen M Laidlaw; Eric G Sheu; Simone Korten; Robert Sinden; Geoffrey Butcher; Michael A Skinner; Adrian V S Hill
Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3094-100.
2004: Margaret Pinder; William H H Reece; Magdalena Plebanski; Peter Akinwunmi; Katie L Flanagan; Edwin A M Lee; Tom Doherty; Paul Milligan; Assan Jaye; Nadia Tornieporth; R Ballou; Keith P W J McAdam; Joe Cohen; Adrian V S Hill
Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia.
Clinical and experimental immunology 2004;135(2):286-93.
2004: Andrew J Walley; Christophe Aucan; Dominic Kwiatkowski; Adrian V S Hill
Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study.
European journal of human genetics : EJHG 2004;12(2):132-8.
2004: Vasee S Moorthy; Michael F Good; Adrian V S Hill
Malaria vaccine developments.
Lancet 2004;363(9403):150-6.
2004: Eric Prieur; Sarah Gilbert; Joerg Schneider; Anne Moore; Eric G Sheu; Nilu Goonetilleke; Kathryn J H Robson; Adrian V S Hill
A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):290-5.
2004: Christophe Aucan; Andrew J Walley; Adrian V S Hill
Common apolipoprotein E polymorphisms and risk of clinical malaria in the Gambia.
Journal of medical genetics 2004;41(1):21-4.
2003: Graham S Cooke; Christophe Aucan; Andrew J Walley; Shelley Segal; Brian M Greenwood; Dominic P Kwiatkowski; Adrian V S Hill
Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa.
The American journal of tropical medicine and hygiene 2003;69(6):565-8.
2003: Simon Hellier; Angela J Frodsham; B J W Hennig; Paul Klenerman; Suzanne Knapp; Patricia A Ramaley; Jack Satsangi; Mark Wright; Lyna Zhang; Howard Thomas; Mark Thursz; Adrian V S Hill
Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.
Hepatology (Baltimore, Md.) 2003;38(6):1468-76.
2003: Evans L N Taracha; Richard Bishop; Anthony J Musoke; Adrian V S Hill; Sarah C Gilbert
Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses.
Infection and immunity 2003;71(12):6906-14.
2003: Roger H Brookes; Ansar A Pathan; Helen McShane; Meike Hensmann; David A Price; Adrian V S Hill
CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages.
European journal of immunology 2003;33(12):3293-302.
2003: Susanna Dunachie; Adrian V S Hill
Prime-boost strategies for malaria vaccine development.
The Journal of experimental biology 2003;206(Pt 21):3771-9.
2003: Vasee S Moorthy; Margaret Pinder; William H H Reece; Kate Watkins; Sowsan Atabani; Carolyn M Hannan; Kalifa Bojang; Keith P W J McAdam; Joerg Schneider; Sarah Gilbert; Adrian V S Hill
Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults.
The Journal of infectious diseases 2003;188(8):1239-44.
2003: Sarah J Campbell; Pardis C Sabeti; Katherine Fielding; Jackson Sillah; Boubacar Bah; Per Gustafson; Kebba Manneh; Ida Maria Lisse; Giorgio Sirugo; Richard Bellamy; Steve Bennett; Peter Aaby; Keith P W J McAdam; Oumou Bah-Sow; Christian Lienhardt; Adrian V S Hill
Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa.
Immunogenetics 2003;55(7):502-7.
2003: Shelley Segal; Adrian V S Hill
Genetic susceptibility to infectious disease.
Trends in microbiology 2003;11(9):445-8.
2003: Susanne Knapp; Leland J Yee; Angela J Frodsham; B J W Hennig; Simon Hellier; Lyna Zhang; Mark Wright; Maria Chiaramonte; M Graves; Howard Thomas; Adrian V S Hill; Mark Thursz
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.
Genes and immunity 2003;4(6):411-9.
2003: Susanne Knapp; B J W Hennig; Angela J Frodsham; Lyna Zhang; Simon Hellier; Mark Wright; Robert Goldin; Adrian V S Hill; Howard Thomas; Mark Thursz
Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection.
Immunogenetics 2003;55(6):362-9.
2003: Nilu Goonetilleke; Helen McShane; Carolyn M Hannan; Richard J Anderson; Roger H Brookes; Adrian V S Hill
Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1602-9.
2003: Peter Zimmerman; J Fitness; Joann M Moulds; David T McNamara; Laurin J Kasehagen; J Alexandra Rowe; Adrian V S Hill
CR1 Knops blood group alleles are not associated with severe malaria in the Gambia.
Genes and immunity 2003;4(5):368-73.
2003: Samuel J McConkey; William H H Reece; Vasee S Moorthy; Daniel Webster; Susanna Dunachie; Geoffrey Butcher; Jenni M Vuola; Tom J Blanchard; Philip K Gothard; Kate Watkins; Carolyn M Hannan; Simone Everaere; Karen Brown; Kent Kester; James Cummings; Jackie Williams; Donald Heppner; Ansar A Pathan; Katie L Flanagan; Nirmalan Arulanantham; Mark T M Roberts; Michael Roy; Geoffrey L Smith; Joerg Schneider; T E A Peto; Robert E Sinden; Sarah Gilbert; Adrian V S Hill
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
Nature medicine 2003;9(6):729-35.
2003: Christophe Aucan; Andrew J Walley; B J W Hennig; Jodene Fitness; Angela J Frodsham; Lyna Zhang; Dominic Kwiatkowski; Adrian V S Hill
Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.
Genes and immunity 2003;4(4):275-82.
2003: Vasee S Moorthy; Samuel J McConkey; M Roberts; Philip K Gothard; Nirmalan Arulanantham; P Degano; Jörg Schneider; Carolyn M Hannan; M Roy; Sarah Gilbert; T E A Peto; Adrian V S Hill
Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
Vaccine 2003;21(17-18):1995-2002.
2003: Katie L Flanagan; Tabitha W Mwangi; Magdalena Plebanski; Kennedy Odhiambo; Amanda Ross; Eric G Sheu; Moses Kortok; Brett Lowe; Kevin Marsh; Adrian V S Hill
Ex vivo interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection.
The American journal of tropical medicine and hygiene 2003;68(4):421-30.
2003: Daniel Webster; Adrian V S Hill
Progress with new malaria vaccines.
Bulletin of the World Health Organization 2003;81(12):902-9.
2002: Graham S Cooke; Shelley Segal; Adrian V S Hill
Toll-like receptor 4 polymorphisms and atherogenesis.
The New England journal of medicine 2002;347(24):1978-80; author reply 1978-80.
2002: Jodene Fitness; Kerrie Tosh; Adrian V S Hill
Genetics of susceptibility to leprosy.
Genes and immunity 2002;3(8):441-53.
2002: Cheuk M Li; Sarah J Campbell; Dinakantha S Kumararatne; Richard Bellamy; Cyril Ruwende; Keith P W J McAdam; Adrian V S Hill; David A Lammas
Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.
The Journal of infectious diseases 2002;186(10):1458-62.
2002: C M Li; Sarah J Campbell; Dinakantha S Kumararatne; Adrian V S Hill; David A Lammas
Response heterogeneity of human macrophages to ATP is associated with P2X7 receptor expression but not to polymorphisms in the P2RX7 promoter.
FEBS letters 2002;531(2):127-31.
2002: Kerrie Tosh; Sarah Meisner; M Ruby Siddiqui; Karuppiah Balakrishnan; Satish Ghei; Marina Golding; Utpal Sengupta; Ramasamy Pitchappan; Adrian V S Hill
A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.
The Journal of infectious diseases 2002;186(8):1190-3.
2002: B J W Hennig; Simon Hellier; Angela J Frodsham; Lyna Zhang; Paul Klenerman; Susanne Knapp; Mark Wright; Howard Thomas; Mark Thursz; Adrian V S Hill
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection.
Genes and immunity 2002;3(6):359-67.
2002: Alessandra C L Cervino; Said Lakiss; Oumou Y Sow; Richard Bellamy; Nulda Beyers; Eileen Hoal-van Helden; Paul van Helden; Keith P W J McAdam; Adrian V S Hill
Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families.
Human molecular genetics 2002;11(14):1599-603.
2002: S Roy; Adrian V S Hill; K Knox; D Griffiths; Derrick W Crook
Research pointers: Association of common genetic variant with susceptibility to invasive pneumococcal disease.
BMJ (Clinical research ed.) 2002;324(7350):1369.
2002: Patricia A Ramaley; French Neil; Pontiano Kaleebu; Charles Gilks; Jimmy Whitworth; Adrian V S Hill
HIV in Africa (Communication arising): chemokine-receptor genes and AIDS risk.
Nature 2002;417(6885):140.
2002: Suchismita Roy; Kyle Knox; Shelley Segal; David Griffiths; Catrin E Moore; Kenneth I Welsh; Alex Smarason; Nicholas P J Day; William L McPheat; Derrick W Crook; Adrian V S Hill
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
Lancet 2002;359(9317):1569-73.
2002: Christophe Aucan; Andrew J Walley; Brian M Greenwood; Adrian V S Hill
Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(3):327-8.
2002: Helen McShane; Shahriar Behboudi; Nilu Goonetilleke; Roger H Brookes; Adrian V S Hill
Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.
Infection and immunity 2002;70(3):1623-6.
2002: William H H Reece; Magdalena Plebanski; Peter Akinwunmi; Philip K Gothard; Katie L Flanagan; Edwin A M Lee; Mario Cortina Borja; Adrian V S Hill; Margaret Pinder
Naturally exposed populations differ in their T1 and T2 responses to the circumsporozoite protein of Plasmodium falciparum.
Infection and immunity 2002;70(3):1468-74.
2002: Edwin A M Lee; Dupeh R Palmer; Katie L Flanagan; William H H Reece; Kennedy Odhiambo; Kevin Marsh; Margaret Pinder; Michael B Gravenor; Wendy A Keitel; Kent Kester; Carter L Diggs; David C Kaslow; Vasso Apostolopoulos; W Ripley Ballou; Adrian V S Hill; Urszula Krzych; Magdalena Plebanski
Induction of T helper type 1 and 2 responses to 19-kilodalton merozoite surface protein 1 in vaccinated healthy volunteers and adults naturally exposed to malaria.
Infection and immunity 2002;70(3):1417-21.
2002: Sarah Gilbert; Jörg Schneider; Carolyn M Hannan; Jiang Ting Hu; Magdalena Plebanski; Robert Sinden; Adrian V S Hill
Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes.
Vaccine 2002;20(7-8):1039-45.
2002: Vasee S Moorthy; Adrian V S Hill
Malaria vaccines.
British medical bulletin 2002;62():59-72.
2001: Sarah Meisner; S Mucklow; G Warner; SO Sow; Christian Lienhardt; Adrian V S Hill
Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.
The American journal of tropical medicine and hygiene 2001;65(6):733-5.
2001: Graham S Cooke; Adrian V S Hill
Genetics of susceptibility to human infectious disease.
Nature reviews. Genetics 2001;2(12):967-77.
2001: Hsin Loke; D B Bethell; Cao Xuan Thanh Phuong; M Dung; Joerg Schneider; Nicholas J White; N P Day; Jeremy Farrar; Adrian V S Hill
Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?
The Journal of infectious diseases 2001;184(11):1369-73.
2001: Ansar A Pathan; Katalin A Wilkinson; Paul Klenerman; Helen McShane; Robert N Davidson; Geoffrey Pasvol; Adrian V S Hill; Ajit Lalvani
Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5217-25.
2001: Katie L Flanagan; Edwin A M Lee; Michael B Gravenor; William H H Reece; Britta C Urban; Tom Doherty; Kalifa Bojang; Margaret Pinder; Adrian V S Hill; Magdalena Plebanski
Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4729-37.
2001: Jörg Schneider; J A Langermans; Sarah Gilbert; Tom J Blanchard; S Twigg; S Naitza; Carolyn M Hannan; M Aidoo; Andrea Crisanti; Kathryn J H Robson; Geoffrey L Smith; Adrian V S Hill; Alan Thomas
A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees.
Vaccine 2001;19(32):4595-602.
2001: Adrian V S Hill
Immunogenetics and genomics.
Lancet 2001;357(9273):2037-41.
2001: Ajit Lalvani; Ansar A Pathan; H Durkan; Katalin A Wilkinson; A Whelan; Jonathan J Deeks; William H H Reece; M Latif; Geoffrey Pasvol; Adrian V S Hill
Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.
Lancet 2001;357(9273):2017-21.
2001: Andrew Godkin; K J Smith; A Willis; M V Tejada-Simon; J Zhang; Tim Elliott; Adrian V S Hill
Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6720-7.
2001: Annette Jepson; A Fowler; Winston Banya; M Singh; Steve Bennett; Hilton Whittle; Adrian V S Hill
Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa.
Infection and immunity 2001;69(6):3989-94.
2001: M Ruby Siddiqui; Sarah Meisner; Kerrie Tosh; K Balakrishnan; Satish Ghei; Simon E Fisher; M Golding; N P Shanker Narayan; T Sitaraman; U Sengupta; Ramasamy Pitchappan; Adrian V S Hill
A major susceptibility locus for leprosy in India maps to chromosome 10p13.
Nature genetics 2001;27(4):439-41.
2001: Edwin A M Lee; Katie L Flanagan; Kennedy Odhiambo; William H H Reece; C Potter; R Bailey; Kevin Marsh; Margaret Pinder; Adrian V S Hill; Magdalena Plebanski
Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence.
The American journal of tropical medicine and hygiene 2001;64(3-4):194-203.
2001: Ajit Lalvani; Ansar A Pathan; Helen McShane; Robert J Wilkinson; M Latif; Christopher Conlon; Geoffrey Pasvol; Adrian V S Hill
Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.
American journal of respiratory and critical care medicine 2001;163(4):824-8.
2001: Helen McShane; Roger H Brookes; Sarah Gilbert; Adrian V S Hill
Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis.
Infection and immunity 2001;69(2):681-6.
2001: Ajit Lalvani; P Nagvenkar; Zarir F Udwadia; Ansar A Pathan; Katalin A Wilkinson; J S Shastri; Katie Ewer; Adrian V S Hill; A Mehta; C Rodrigues
Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians.
The Journal of infectious diseases 2001;183(3):469-77.
2000: Steve M Smith; Roger H Brookes; Michel Klein; AS Malin; Pauline T Lukey; Abigail S Bailey; Graham S Ogg; Adrian V S Hill; Hazel M Dockrell
Human CD8+ CTL specific for the mycobacterial major secreted antigen 85A.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7088-95.
2000: Alessandra C L Cervino; S Lakiss; Oumou Y Sow; Adrian V S Hill
Allelic association between the NRAMP1 gene and susceptibility to tuberculosis in Guinea-Conakry.
Annals of human genetics 2000;64(Pt 6):507-12.
2000: J Ansell; Jiang Ting Hu; Sarah Gilbert; KA Hamilton; Adrian V S Hill; Steven W Lindsay
Improved method for distinguishing the human source of mosquito blood meals between close family members.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):572-4.
2000: Ansar A Pathan; Katalin A Wilkinson; Robert J Wilkinson; M Latif; Helen McShane; G Pasvol; Adrian V S Hill; A Lalvani
High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.
European journal of immunology 2000;30(9):2713-21.
2000: Richard Bellamy; Nulda Beyers; Keith P W J McAdam; Cyril Ruwende; R Gie; P Samaai; D Bester; M Meyer; Tumani Corrah; M Collin; D R Camidge; D Wilkinson; Eileen Hoal-van Helden; Hilton C Whittle; W Amos; Paul van Helden; Adrian V S Hill
Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8005-9.
2000: Alessandra C L Cervino; Adrian V S Hill
Comparison of tests for association and linkage in incomplete families.
American journal of human genetics 2000;67(1):120-32.
2000: R P Anderson; P Degano; Andrew Godkin; DP Jewell; Adrian V S Hill
In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope.
Nature medicine 2000;6(3):337-42.
2000: S Ali; M A Niang; Ibraham N'Doye; Cathy W Critchlow; Stephen E Hawes; Adrian V S Hill; Nancy B Kiviat
Secretor polymorphism and human immunodeficiency virus infection in Senegalese women.
The Journal of infectious diseases 2000;181(2):737-9.
2000: Adrian V S Hill; William H H Reece; Philip K Gothard; Vasee S Moorthy; M Roberts; Katie L Flanagan; Magdalena Plebanski; Carolyn M Hannan; Jiang Ting Hu; R Anderson; P Degano; Jörg Schneider; Eric Prieur; Eric G Sheu; Sarah Gilbert
DNA-based vaccines for malaria: a heterologous prime-boost immunisation strategy.
Developments in biologicals 2000;104():171-9.
2000: M Aidoo; Ajit Lalvani; Sarah Gilbert; Jiang Ting Hu; P Daubersies; N Hurt; Hilton C Whittle; P Druihle; Adrian V S Hill
Cytotoxic T-lymphocyte epitopes for HLA-B53 and other HLA types in the malaria vaccine candidate liver-stage antigen 3.
Infection and immunity 2000;68(1):227-32.
1999: P Dégano; Joerg Schneider; Carolyn M Hannan; Sarah Gilbert; Adrian V S Hill
Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: enhanced CD8+ T cell immunogenicity and protective efficacy in the influenza and malaria models.
Vaccine 1999;18(7-8):623-32.
1999: Ajit Lalvani; P Moris; Gerald Voss; Ansar A Pathan; Kent Kester; Roger H Brookes; E Lee; Marguerite Koutsoukos; Magdalena Plebanski; Martine Delchambre; Katie L Flanagan; C Carton; Moncef Slaoui; C Van Hoecke; W Ripley Ballou; Adrian V S Hill; Joe Cohen
Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine.
The Journal of infectious diseases 1999;180(5):1656-64.
1999: Jörg Schneider; Sarah Gilbert; Carolyn M Hannan; P Dégano; Eric Prieur; Eric G Sheu; Magdalena Plebanski; Adrian V S Hill
Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.
Immunological reviews 1999;170():29-38.
1999: Adrian V S Hill
The immunogenetics of resistance to malaria.
Proceedings of the Association of American Physicians 1999;111(4):272-7.
1999: Magdalena Plebanski; Katie L Flanagan; Edwin A M Lee; William H H Reece; K Hart; C Gelder; G Gillespie; Margaret Pinder; Adrian V S Hill
Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.
Immunity 1999;10(6):651-60.
1999: Katie L Flanagan; Magdalena Plebanski; Peter Akinwunmi; Edwin A M Lee; William H H Reece; Kathryn J H Robson; Adrian V S Hill; Margaret Pinder
Broadly distributed T cell reactivity, with no immunodominant loci, to the pre-erythrocytic antigen thrombospondin-related adhesive protein of Plasmodium falciparum in West Africans.
European journal of immunology 1999;29(6):1943-54.
1999: Magdalena Plebanski; Edwin A M Lee; Carolyn M Hannan; Katie L Flanagan; Sarah Gilbert; Michael B Gravenor; Adrian V S Hill
Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming.
Nature medicine 1999;5(5):565-71.
1999: Sarah Gilbert; Jörg Schneider; Magdalena Plebanski; Carolyn M Hannan; Tom J Blanchard; Geoffrey L Smith; Adrian V S Hill
Ty virus-like particles, DNA vaccines and Modified Vaccinia Virus Ankara; comparisons and combinations.
Biological chemistry 1999;380(3):299-303.
1999: Richard Bellamy; Cyril Ruwende; Tumani Corrah; Keith P W J McAdam; Mark Thursz; Hilton C Whittle; Adrian V S Hill
Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene.
The Journal of infectious diseases 1999;179(3):721-4.
1999: Tomás Hanke; V C Neumann; Tom J Blanchard; P Sweeney; Adrian V S Hill; Geoffrey L Smith; Andrew McMichael
Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime.
Vaccine 1999;17(6):589-96.
1999: Adrian V S Hill
Genetics and genomics of infectious disease susceptibility.
British medical bulletin 1999;55(2):401-13.
1999: S Roy; A Frodsham; B Saha; S K Hazra; C G N Mascie-Taylor; Adrian V S Hill
Association of vitamin D receptor genotype with leprosy type.
The Journal of infectious diseases 1999;179(1):187-91.
1998: Sarah Gilbert; Adrian V S Hill
The SPf66 Malaria Vaccine: Where Do We Go From Here?
Parasitology today (Personal ed.) 1998;14(6):251.
1998: Magdalena Plebanski; Sarah Gilbert; Jörg Schneider; Carolyn M Hannan; Guy T Layton; Tom J Blanchard; M Becker; G Smith; Geoffrey Butcher; Robert E Sinden; Adrian V S Hill
Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use.
European journal of immunology 1998;28(12):4345-55.
1998: A Lalvani; Adrian V S Hill
Cytotoxic T-lymphocytes against malaria and tuberculosis: from natural immunity to vaccine design.
Clinical science (London, England : 1979) 1998;95(5):531-8.
1998: Kirk Rockett; Roger H Brookes; Irina A Udalova; vincent vidal; Adrian V S Hill; Dominic Kwiatkowski
1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line.
Infection and immunity 1998;66(11):5314-21.
1998: Richard Bellamy; Adrian V S Hill
Genetic susceptibility to mycobacteria and other infectious pathogens in humans.
Current opinion in immunology 1998;10(4):483-7.
1998: Andrew Godkin; M P Davenport; A Willis; DP Jewell; Adrian V S Hill
Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):850-8.
1998: Richard Bellamy; Dominic Kwiatkowski; Adrian V S Hill
Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(3):312-6.
1998: Jörg Schneider; Sarah Gilbert; Tom J Blanchard; T Hanke; Kathryn J H Robson; Carolyn M Hannan; M Becker; Robert Sinden; Geoffrey L Smith; Adrian V S Hill
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.
Nature medicine 1998;4(4):397-402.
1998: Richard Bellamy; Cyril Ruwende; Tumani Corrah; Keith P W J McAdam; Hilton C Whittle; Adrian V S Hill
Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.
The New England journal of medicine 1998;338(10):640-4.
1998: T Hanke; Tom J Blanchard; Joerg Schneider; Carolyn M Hannan; M Becker; Sarah Gilbert; Adrian V S Hill; Geoffrey L Smith; Andrew McMichael
Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime.
Vaccine 1998;16(5):439-45.
1998: Sarah Gilbert; Magdalena Plebanski; S Gupta; J Morris; M Cox; M Aidoo; D Kwiatkowski; B M Greenwood; Hilton C Whittle; Adrian V S Hill
Association of malaria parasite population structure, HLA, and immunological antagonism.
Science (New York, N.Y.) 1998;279(5354):1173-7.
1998: Tomás Hanke; Jörg Schneider; Sarah Gilbert; Adrian V S Hill; Andrew McMichael
DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice.
Vaccine 1998;16(4):426-35.
1998: Ajit Lalvani; Roger H Brookes; Robert J Wilkinson; AS Malin; Ansar A Pathan; P Andersen; H Dockrell; Geoffrey Pasvol; Adrian V S Hill
Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):270-5.
1998: Richard Bellamy; Cyril Ruwende; Tumani Corrah; Keith P W J McAdam; Hilton C Whittle; Adrian V S Hill
Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1998;79(2):83-9.
1998: Richard Bellamy; Adrian V S Hill
Host genetic susceptibility to human tuberculosis.
Novartis Foundation symposium 1998;217():3-13; discussion 13-23.
1998: Adrian V S Hill
The immunogenetics of human infectious diseases.
Annual review of immunology 1998;16():593-617.
1998: Richard Bellamy; Cyril Ruwende; Keith P W J McAdam; Mark Thursz; M Sumiya; John A Summerfield; Sarah Gilbert; Tumani Corrah; Dominic Kwiatkowski; Hilton C Whittle; Adrian V S Hill
Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans.
QJM : monthly journal of the Association of Physicians 1998;91(1):13-8.
1998: Tomás Hanke; Tom J Blanchard; Jörg Schneider; Graham S Ogg; R Tan; M Becker; Sarah Gilbert; Adrian V S Hill; Geoffrey L Smith; Andrew McMichael
Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice.
The Journal of general virology 1998;79 ( Pt 1)():83-90.
1997: Ajit Lalvani; Tao Dong; Graham S Ogg; A A Patham; H Newell; Adrian V S Hill; Andrew J McMichael; Sarah Rowland-Jones
Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors.
Journal of immunological methods 1997;210(1):65-77.
1997: Sarah Gilbert; Magdalena Plebanski; SJ Harris; C E Allsopp; R Thomas; Guy T Layton; Adrian V S Hill
A protein particle vaccine containing multiple malaria epitopes.
Nature biotechnology 1997;15(12):1280-4.
1997: Adrian V S Hill; Annette Jepson; M Plebanski; S C Gilbert
Genetic analysis of host-parasite coevolution in human malaria.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1997;352(1359):1317-25.
1997: Sarah Gilbert; Adrian V S Hill
Protein particle vaccines against malaria.
Parasitology today (Personal ed.) 1997;13(8):302-6.
1997: Annette Jepson; F Sisay-Joof; Winston Banya; M Hassan-King; A Frodsham; Steve Bennett; Adrian V S Hill; Hilton Whittle
Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs.
BMJ (Clinical research ed.) 1997;315(7100):96-7.
1997: Adrian V S Hill
Genetic susceptibility to multifactorial diseases.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(4):369-71.
1997: M Aidoo; Ajit Lalvani; Hilton C Whittle; Adrian V S Hill; Kathryn J H Robson
Recombinant vaccinia viruses for the characterization of Plasmodium falciparum-specific cytotoxic T lymphocytes: recognition of processed antigen despite limited re-stimulation efficacy.
International immunology 1997;9(5):731-7.
1997: Magdalena Plebanski; M Aidoo; Hilton C Whittle; Adrian V S Hill
Precursor frequency analysis of cytotoxic T lymphocytes to pre-erythrocytic antigens of Plasmodium falciparum in West Africa.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2849-55.
1997: M P Davenport; K J Smith; D Barouch; S W Reid; Wanda Bodnar; A C Willis; Donald F Hunt; Adrian V S Hill
HLA class I binding motifs derived from random peptide libraries differ at the COOH terminus from those of eluted peptides.
The Journal of experimental medicine 1997;185(2):367-71.
1997: Magdalena Plebanski; Edwin A M Lee; Adrian V S Hill
Immune evasion in malaria: altered peptide ligands of the circumsporozoite protein.
Parasitology 1997;115 Suppl():S55-66.
1997: M P Davenport; Andrew Godkin; T Friede; S Stevanović; A C Willis; Adrian V S Hill; H G Rammensee
A distinctive peptide binding motif for HLA-DRB1*0407, an HLA-DR4 subtype not associated with rheumatoid arthritis.
Immunogenetics 1997;45(3):229-32.
1996: M P Davenport; Cheryl Quinn; P Valsasnini; F Sinigaglia; Adrian V S Hill; John I Bell
Analysis of peptide-binding motifs for two disease associated HLA-DR13 alleles using an M13 phage display library.
Immunology 1996;88(4):482-6.
1996: C E Allsopp; Magdalena Plebanski; S Gilbert; R E Sinden; S Harris; G Frankel; G Dougan; C Hioe; D Nixon; E Paoletti; Guy T Layton; Adrian V S Hill
Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization.
European journal of immunology 1996;26(8):1951-9.
1996: W McGuire; Adrian V S Hill; Brian M Greenwood; Dominic Kwiatkowski
Circulating ICAM-1 levels in falciparum malaria are high but unrelated to disease severity.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(3):274-6.
1996: Ajit Lalvani; N Hurt; M Aidoo; P Kibatala; M Tanner; Adrian V S Hill
Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania.
European journal of immunology 1996;26(4):773-9.
1996: Adrian V S Hill
HIV and HLA: confusion or complexity?
Nature medicine 1996;2(4):395-6.
1996: M P Davenport; Adrian V S Hill
Reverse immunogenetics: from HLA-disease associations to vaccine candidates.
Molecular medicine today 1996;2(1):38-45.
1996: Adrian V S Hill
Genetic susceptibility to malaria and other infectious diseases: from the MHC to the whole genome.
Parasitology 1996;112 Suppl():S75-84.
1995: M P Davenport; C L Quinn; R M Chicz; B N Green; A C Willis; William Stratton Lane; John I Bell; Adrian V S Hill
Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DR beta chain.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6567-71.
1995: Magdalena Plebanski; C E Allsopp; M Aidoo; H Reyburn; Adrian V S Hill
Induction of peptide-specific primary cytotoxic T lymphocyte responses from human peripheral blood.
European journal of immunology 1995;25(6):1783-7.
1995: Mark Thursz; Dominic Kwiatkowski; C E Allsopp; B M Greenwood; Howard Thomas; Adrian V S Hill
Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia.
The New England journal of medicine 1995;332(16):1065-9.
1995: Mark Thursz; Dominic Kwiatkowski; Mili Estee Torok; C E Allsopp; B M Greenwood; Hilton C Whittle; Howard Thomas; Adrian V S Hill
Association of hepatitis B surface antigen carriage with severe malaria in Gambian children.
Nature medicine 1995;1(4):374-5.
1995: M P Davenport; I A Ho Shon; Adrian V S Hill
An empirical method for the prediction of T-cell epitopes.
Immunogenetics 1995;42(5):392-7.
1994: Adrian V S Hill; S N Yates; C E Allsopp; S Gupta; Sarah Gilbert; Ajit Lalvani; M Aidoo; M Davenport; Magdalena Plebanski
Human leukocyte antigens and natural selection by malaria.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;346(1317):379-85.
1994: W McGuire; Adrian V S Hill; C E Allsopp; Brian M Greenwood; Dominic Kwiatkowski
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
Nature 1994;371(6497):508-10.
1994: Ajit Lalvani; M Aidoo; C E Allsopp; Magdalena Plebanski; H C Whittle; Adrian V S Hill
An HLA-based approach to the design of a CTL-inducing vaccine against Plasmodium falciparum.
Research in immunology 1994;145(6):461-8.
1994: Adrian V S Hill; M Aidoo; C E Allsopp; M Davenport; S N Yates
Interactions between Plasmodium falciparum and HLA molecules.
Biochemical Society transactions 1994;22(2):282-5.
1994: Sunetra Gupta; Adrian V S Hill; Dominic Kwiatkowski; A M Greenwood; Brian M Greenwood; Karen P Day
Parasite virulence and disease patterns in Plasmodium falciparum malaria.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3715-9.
1993: Frances Gotch; S McAdam; C E Allsopp; A Gallimore; J Elvin; M P Kieny; Adrian V S Hill; Andrew J McMichael; Hilton C Whittle
Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3361-9.
1993: Malcolm W Turner; R J Lipscombe; Roland J Levinsky; Y L Lau; Adrian V S Hill; John A Summerfield; Michiko Sumiya
Mutations in the human mannose binding protein gene: their frequencies in three distinct populations and relationship to serum levels of the protein.
Immunodeficiency 1993;4(1-4):285-7.
1992: Adrian V S Hill; J Elvin; A C Willis; M Aidoo; C E Allsopp; F M Gotch; X M Gao; M Takiguchi; Brian M Greenwood; A R Townsend
Molecular analysis of the association of HLA-B53 and resistance to severe malaria.
Nature 1992;360(6403):434-9.
1992: R J Lipscombe; Michiko Sumiya; Adrian V S Hill; Y L Lau; Roland J Levinsky; John A Summerfield; Malcolm W Turner
High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.
Human molecular genetics 1992;1(9):709-15.
1992: Adrian V S Hill
Malaria resistance genes: a natural selection.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86(3):225-6, 232.
1992: Adrian V S Hill; C E Allsopp; Dominic Kwiatkowski; Terrie E Taylor; S N Yates; Nicholas Anstey; J J Wirima; D R Brewster; Andrew J McMichael; M E Molyneux
Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2277-81.
1992: Adrian V S Hill; S Bennett; C E Allsopp; D Kwiatkowski; Nicholas Anstey; P Twumasi; P A Rowe; D Brewster; A J McMichael; B M Greenwood
HLA, malaria and dominant protective associations.
Parasitology today (Personal ed.) 1992;8(2):57.
1992: C E Allsopp; R M Harding; C Taylor; M Bunce; Dominic Kwiatkowski; N Anstey; D Brewster; Andrew J McMichael; Brian M Greenwood; Adrian V S Hill
Interethnic genetic differentiation in Africa: HLA class I antigens in The Gambia.
American journal of human genetics 1992;50(2):411-21.
1991: Adrian V S Hill; C E Allsopp; Dominic Kwiatkowski; Nicholas Anstey; P Twumasi; P A Rowe; S Bennett; D Brewster; Andrew J McMichael; Brian M Greenwood
Common west African HLA antigens are associated with protection from severe malaria.
Nature 1991;352(6336):595-600.
1991: Adrian V S Hill; C E Allsopp; Dominic Kwiatkowski; Nicholas Anstey; Brian M Greenwood; Andrew J McMichael
HLA class I typing by PCR: HLA-B27 and an African B27 subtype.
Lancet 1991;337(8742):640-2.
1991: C E Allsopp; Adrian V S Hill; Dominic Kwiatkowski; A Hughes; M Bunce; C J Taylor; L Pazmany; D Brewster; Andrew J McMichael; Brian M Greenwood
Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35.
Human immunology 1991;30(2):105-9.
1990: Dominic Kwiatkowski; Adrian V S Hill; I Sambou; P Twumasi; J Castracane; K R Manogue; A Cerami; D R Brewster; Brian M Greenwood
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.
Lancet 1990;336(8725):1201-4.
1990: D F O'Shaughnessy; Adrian V S Hill; DK Bowden; David J Weatherall; John B Clegg
Globin genes in Micronesia: origins and affinities of Pacific Island peoples.
American journal of human genetics 1990;46(1):144-55.
1988: David J Weatherall; J I Bell; John B Clegg; J Flint; D R Higgs; Adrian V S Hill; G Pasvol; S L Thein
Genetic factors as determinants of infectious disease transmission in human communities.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;321(1207):327-48.
1988: Adrian V S Hill; DK Bowden; D F O'Shaughnessy; David J Weatherall; John B Clegg
Beta thalassemia in Melanesia: association with malaria and characterization of a common variant (IVS-1 nt 5 G----C).
Blood 1988;72(1):9-14.
1987: Adrian V S Hill; S L Thein; B Mavo; David J Weatherall; John B Clegg
Non-deletion haemoglobin H disease in Papua New Guinea.
Journal of medical genetics 1987;24(12):767-71.
1987: Adrian V S Hill
Haemoglobinopathies and malaria: new approaches to an old hypothesis.
Parasitology today (Personal ed.) 1987;3(3):83-5.
1987: DK Bowden; Adrian V S Hill; D R Higgs; S J Oppenheimer; David J Weatherall; John B Clegg
Different hematologic phenotypes are associated with the leftward (-alpha 4.2) and rightward (-alpha 3.7) alpha+-thalassemia deletions.
The Journal of clinical investigation 1987;79(1):39-43.
1987: Adrian V S Hill; David Whitehouse; DK Bowden; D A Hopkinson; C C Draper; T E A Peto; John B Clegg; David J Weatherall
Ahaptoglobinaemia in Melanesia: DNA and malarial antibody studies.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1987;81(4):573-7.
1987: Adrian V S Hill; J Flint; David J Weatherall; John B Clegg
Alpha-thalassaemia and the malaria hypothesis.
Acta haematologica 1987;78(2-3):173-9.
1986: Jonathan Flint; Adrian V S Hill; DK Bowden; S J Oppenheimer; P R Sill; S W Serjeantson; J Bana-Koiri; K Bhatia; M P Alpers; Anthony J Boyce
High frequencies of alpha-thalassaemia are the result of natural selection by malaria.
Nature 1986;321(6072):744-50.
1986: Adrian V S Hill; DK Bowden; Jonathan Flint; David Whitehouse; D A Hopkinson; S J Oppenheimer; S W Serjeantson; John B Clegg
A population genetic survey of the haptoglobin polymorphism in Melanesians by DNA analysis.
American journal of human genetics 1986;38(3):382-9.
1985: Adrian V S Hill; DK Bowden; R J Trent; D R Higgs; S J Oppenheimer; S L Thein; K N Mickleson; David J Weatherall; John B Clegg
Melanesians and Polynesians share a unique alpha-thalassemia mutation.
American journal of human genetics 1985;37(3):571-80.