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Yehuda Assaraf

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Sue Ellen Verbrugge; Sonja Zweegman; Marjon Al; Janet L Anderl; Yehuda G Assaraf; Elena T Chan; Jacqueline Cloos; Tanja D de Gruijl; Ben Ac Dijkmans; Christopher J Kirk; Willem F Lems; Denise Niewerth; Godefridus J Peters; George L Scheffer; Rik J Scheper; Michael van der Veer; Johan van Meerloo; Gerrit Jansen
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
Inbal Lasry; Jacob Levy; Ben Pode-Shakked; Young Ah Seo; Nechama Shalva; Igor N Berezovsky; Bluma Berman; Fabian Glaser; Alexander Goncearenco; Hadas Ityel; Shannon L Kelleher; Aharon Klar; Yair Anikster; Yehuda G Assaraf
A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.
Nitzan Gonen; Yehuda G Assaraf
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance.

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2013: Sue Ellen Verbrugge; Sonja Zweegman; Marjon Al; Janet L Anderl; Yehuda G Assaraf; Elena T Chan; Jacqueline Cloos; Tanja D de Gruijl; Ben Ac Dijkmans; Christopher J Kirk; Willem F Lems; Denise Niewerth; Godefridus J Peters; George L Scheffer; Rik J Scheper; Michael van der Veer; Johan van Meerloo; Gerrit Jansen
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
Experimental hematology & oncology 2013;2(1):2.
2012: Inbal Lasry; Jacob Levy; Ben Pode-Shakked; Young Ah Seo; Nechama Shalva; Igor N Berezovsky; Bluma Berman; Fabian Glaser; Alexander Goncearenco; Hadas Ityel; Shannon L Kelleher; Aharon Klar; Yair Anikster; Yehuda G Assaraf
A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.
The Journal of biological chemistry 2012;287(35):29348-61.
2012: Nitzan Gonen; Yehuda G Assaraf
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2012;15(4):183-210.
2012: Vicky Goler-Baron; Irina Sladkevich; Yehuda G Assaraf
Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells.
Biochemical pharmacology 2012;83(10):1340-8.
2012: Sue Ellen Verbrugge; Marjon Al; Yehuda G Assaraf; Elena T Chan; Tanja D de Gruijl; Debby den Uyl; Ben A C Dijkmans; Christopher J Kirk; Ruud Oerlemans; Godefridus J Peters; George L Scheffer; Rik J Scheper; Joost van der Heijden; Gerrit Jansen
Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2012;341(1):174-82.
2012: Alina Shapira; Yehuda G Assaraf; Noa Avni; Irit Davidson; Yoav D Livney
β-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: stability, target-activated release and cytotoxicity.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;80(2):298-305.
2012: Vicky Goler-Baron; Yehuda G Assaraf
Overcoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeutics.
PloS one 2012;7(4):e35487.
2012: Y Adar; Eran Bram; A W Griffioen; P Nowak-Sliwinska; T Sarna; Andrzej Skladanowski; Michal Stark; G Szewczyk; H van den Bergh; Yehuda G Assaraf
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers.
Cell death & disease 2012;3():e293.
2011: Alina Shapira; Henk J Broxterman; Yoav D Livney; Yehuda G Assaraf
Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2011;14(3):150-63.
2011: Michal Stark; Eran E Bram; Martin Akerman; Yael Mandel-Gutfreund; Yehuda G Assaraf
Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.
The Journal of biological chemistry 2011;286(5):3741-54.
2011: Clara Lemos; Elisa Giovannetti; Paolo A Zucali; Yehuda G Assaraf; George L Scheffer; Tahar van der Straaten; Armida D'Incecco; Alfredo Falcone; Henk-Jan Guchelaar; Romano Danesi; Armando Santoro; Giuseppe Giaccone; Carmelo Tibaldi; Godefridus J Peters
Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.
Pharmacogenomics 2011;12(2):159-70.
2011: Vicky Goler-Baron; Yehuda G Assaraf
Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance.
PloS one 2011;6(1):e16007.
2010: Nitzan Gonen; Yehuda G Assaraf
The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.
The Journal of biological chemistry 2010;285(44):33602-13.
2010: Costa Bachas; Gerrit Jan Schuurhuis; Iris H I M Hollink; Zinia J Kwidama; Bianca F Goemans; Christian M Zwaan; Marry M van den Heuvel-Eibrink; Eveline S J M de Bont; Dirk Reinhardt; Ursula Creutzig; Valerie de Haas; Yehuda G Assaraf; Gertjan J L Kaspers; Jacqueline Cloos
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine.
Blood 2010;116(15):2752-8.
2010: Alina Shapira; Yehuda G Assaraf; Dikla Epstein; Yoav D Livney
Beta-casein nanoparticles as an oral delivery system for chemotherapeutic drugs: impact of drug structure and properties on co-assembly.
Pharmaceutical research 2010;27(10):2175-86.
2010: Alina Shapira; Gilad Markman; Yehuda G Assaraf; Yoav D Livney
Beta-casein-based nanovehicles for oral delivery of chemotherapeutic drugs: drug-protein interactions and mitoxantrone loading capacity.
Nanomedicine : nanotechnology, biology, and medicine 2010;6(4):547-55.
2010: Alina Shapira; Yehuda G Assaraf; Yoav D Livney
Beta-casein nanovehicles for oral delivery of chemotherapeutic drugs.
Nanomedicine : nanotechnology, biology, and medicine 2010;6(1):119-26.
2010: Roy I Pinhassi; Yehuda G Assaraf; Shimon Farber; Michal Stark; Diana Ickowicz; Stavit Drori; Abraham J Domb; Yoav D Livney
Arabinogalactan-folic acid-drug conjugate for targeted delivery and target-activated release of anticancer drugs to folate receptor-overexpressing cells.
Biomacromolecules 2010;11(1):294-303.
2009: Eran Bram; Michal Stark; Shachar Raz; Yehuda G Assaraf
Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Neoplasia (New York, N.Y.) 2009;11(12):1359-70.
2009: Viktoria Held-Kuznetsov; Shahar Rotem; Yehuda G Assaraf; Amram Mor
Host-defense peptide mimicry for novel antitumor agents.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4299-307.
2009: Michal Stark; Nitzan Gonen; Yehuda G Assaraf
Functional elements in the minimal promoter of the human proton-coupled folate transporter.
Biochemical and biophysical research communications 2009;388(1):79-85.
2009: Lioz Etgar; Gregory Leitus; Leonid Fradkin; Yehuda G Assaraf; Rina Tannenbaum; Efrat Lifshitz
Optical and magnetic properties of conjugate structures of PbSe quantum dots and gamma-Fe(2)O(3) nanoparticles.
Chemphyschem : a European journal of chemical physics and physical chemistry 2009;10(13):2235-41.
2009: Inbal Lasry; Bluma Berman; Fabian Glaser; Gerrit Jansen; Yehuda G Assaraf
Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.
Biochemical and biophysical research communications 2009;386(3):426-31.
2009: Eran Bram; Yamit Adar; Nufar Mesika; Michal Sabisz; Andrzej Skladanowski; Yehuda G Assaraf
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Molecular pharmacology 2009;75(5):1149-59.
2009: Michal Stark; Chen Wichman; Irit Avivi; Yehuda G Assaraf
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Blood 2009;113(18):4362-9.
2009: Alan Kambiz Fotoohi; Yehuda G Assaraf; Ali Moshfegh; Jamileh Hashemi; Gerrit Jansen; Godefridus J Peters; Catharina Larsson; Freidoun Albertioni
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Biochemical pharmacology 2009;77(8):1410-7.
2009: Joost van der Heijden; Ruud Oerlemans; Paul P Tak; Yehuda G Assaraf; Maarten C Kraan; George L Scheffer; Conny J van der Laken; Willem F Lems; Rik J Scheper; Ben A C Dijkmans; Gerrit Jansen
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.
Arthritis and rheumatism 2009;60(3):669-77.
2009: Ilan Ifergan; Vicky Goler-Baron; Yehuda G Assaraf
Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells.
Biochemical and biophysical research communications 2009;380(1):5-10.
2008: Nitzan Gonen; Eran Bram; Yehuda G Assaraf
PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells.
Biochemical and biophysical research communications 2008;376(4):787-92.
2008: Ruud Oerlemans; Niels E Franke; Yehuda G Assaraf; Jacqueline Cloos; Ina van Zantwijk; Celia R Berkers; George L Scheffer; Kabir Debipersad; Katharina Vojtekova; Clara Lemos; Joost W van der Heijden; Bauke Ylstra; Godefridus J Peters; Gertjan L Kaspers; Ben A C Dijkmans; Rik J Scheper; Gerrit Jansen
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.
Blood 2008;112(6):2489-99.
2008: Inbal Lasry; Bluma Berman; Rachel Straussberg; Yael Sofer; Hanna Bessler; Mohamad Sharkia; Fabian Glaser; Gerrit Jansen; Stavit Drori; Yehuda G Assaraf
A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.
Blood 2008;112(5):2055-61.
2008: Ilan Ifergan; Gerrit Jansen; Yehuda G Assaraf
The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis.
The Journal of biological chemistry 2008;283(30):20687-95.
2008: Ilan Ifergan; Yehuda G Assaraf
Molecular mechanisms of adaptation to folate deficiency.
Vitamins and hormones 2008;79():99-143.
2007: Ruud Oerlemans; Jacqueline M Vink; B A C Dijkmans; Yehuda G Assaraf; Marjolein van Miltenburg; Joost van der Heijden; Ilan Ifergan; Willem F Lems; Rik J Scheper; G J L Kaspers; Jacqueline Cloos; Gerrit Jansen
Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis.
Annals of the rheumatic diseases 2007;66(10):1289-95.
2007: Eran Bram; Ilan Ifergan; Michal Grimberg; Krzysztof Lemke; Andrzej Skladanowski; Yehuda G Assaraf
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Biochemical pharmacology 2007;74(1):41-53.
2007: Yehuda G Assaraf
Molecular basis of antifolate resistance.
Cancer metastasis reviews 2007;26(1):153-81.
2006: Eran Bram; Ilan Ifergan; Assaf Shafran; Bluma Berman; Gerrit Jansen; Yehuda G Assaraf
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Cancer chemotherapy and pharmacology 2006;58(6):826-34.
2006: Yehuda G Assaraf
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(4-5):227-46.
2006: Yehuda G Assaraf; Ilan Ifergan; Wisam N Kadry; Ron Y Pinter
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Journal of theoretical biology 2006;240(4):637-47.
2006: Yotam Kaufman; Ilan Ifergan; Lilah Rothem; Gerrit Jansen; Yehuda G Assaraf
Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.
Blood 2006;107(8):3288-94.
2006: Ruud Oerlemans; Joost van der Heijden; Jacqueline M Vink; B A C Dijkmans; G J L Kaspers; Willem F Lems; George L Scheffer; Ilan Ifergan; Rik J Scheper; Jacqueline Cloos; Yehuda G Assaraf; Gerrit Jansen
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
Arthritis and rheumatism 2006;54(2):557-68.
2006: Michal Stark; Yehuda G Assaraf
Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier.
Blood 2006;107(2):708-15.
2005: Ilan Ifergan; George L Scheffer; Yehuda G Assaraf
Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.
Cancer research 2005;65(23):10952-8.
2005: Liat Binyamin; Yehuda G Assaraf; Yoram Reiter
Probing ATP-dependent conformational changes in the multidrug resistance protein 1 (MRP1/ABCC1) in live tumor cells with a novel recombinant single-chain Fv antibody targeted to the extracellular N-terminus.
International journal of cancer. Journal international du cancer 2005;116(5):703-9.
2005: Assaf Shafran; Ilan Ifergan; Eran Bram; Gerrit Jansen; Ietje Kathmann; Godefridus J Peters; Robert W Robey; Susan E Bates; Yehuda G Assaraf
ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.
Cancer research 2005;65(18):8414-22.
2005: Lilah Rothem; Bluma Berman; Michal Stark; Gerrit Jansen; Yehuda G Assaraf
The reduced folate carrier gene is a novel selectable marker for recombinant protein overexpression.
Molecular pharmacology 2005;68(3):616-24.
2005: Ilan Ifergan; Gerrit Jansen; Yehuda G Assaraf
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.
Molecular pharmacology 2005;67(4):1349-59.
2004: Kambiz Fotoohi; Gerrit Jansen; Yehuda G Assaraf; Lilah Rothem; Michal Stark; Ietje Kathmann; Jacek Gregorczyk; Godefridus J Peters; Freidoun Albertioni
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Blood 2004;104(13):4194-201.
2004: Lilah Rothem; Michal Stark; Yehuda G Assaraf
Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.
Molecular pharmacology 2004;66(6):1536-43.
2004: Michiel de Bruin; Godefridus J Peters; Ruud Oerlemans; Yehuda G Assaraf; Allan J Masterson; Auke D Adema; B A C Dijkmans; HERBERT PINEDO; Gerrit Jansen
Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.
Molecular pharmacology 2004;66(4):1054-60.
2004: Liat Binyamin; Yehuda G Assaraf; Maya Haus-Cohen; Michal Stark; Yoram Reiter
Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.
International journal of cancer. Journal international du cancer 2004;110(6):882-90.
2004: Gerrit Jansen; Joost van der Heijden; Ruud Oerlemans; Willem F Lems; Ilan Ifergan; Rik J Scheper; Yehuda G Assaraf; B A C Dijkmans
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(7):2130-9.
2004: Ilan Ifergan; Assaf Shafran; Gerrit Jansen; Jan Hendrik Hooijberg; George L Scheffer; Yehuda G Assaraf
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.
The Journal of biological chemistry 2004;279(24):25527-34.
2004: Maya Haus-Cohen; Yehuda G Assaraf; Liat Binyamin; Itai Benhar; Yoram Reiter
Disruption of P-glycoprotein anticancer drug efflux activity by a small recombinant single-chain Fv antibody fragment targeted to an extracellular epitope.
International journal of cancer. Journal international du cancer 2004;109(5):750-8.
2004: Jan Hendrik Hooijberg; Gerrit Jansen; Yehuda G Assaraf; Ietje Kathmann; Rob Pieters; Adrie C Laan; Anjo J P Veerman; G J L Kaspers; Godefridus J Peters
Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).
Biochemical pharmacology 2004;67(8):1541-8.
2004: Yotam Kaufman; Stavit Drori; Peter Cole; Barton A. Kamen; Jenny Sirota; Ilan Ifergan; Myriam Weyl Ben Arush; Ronit Elhasid; Dvora Sahar; G J L Kaspers; Gerrit Jansen; Larry H Matherly; Gideon Rechavi; Amos Toren; Yehuda G Assaraf
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Cancer 2004;100(4):773-82.
2004: Joost van der Heijden; Mariska C de Jong; B A C Dijkmans; Willem F Lems; Ruud Oerlemans; Ietje Kathmann; George L Scheffer; Rik J Scheper; Yehuda G Assaraf; Gerrit Jansen
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.
Annals of the rheumatic diseases 2004;63(2):131-7.
2004: Lilah Rothem; Michal Stark; Yotam Kaufman; lior mayo; Yehuda G Assaraf
Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.
The Journal of biological chemistry 2004;279(1):374-84.
2003: Dana Baron; Yehuda G Assaraf; Stavit Drori; Ami Aronheim
Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family.
European journal of biochemistry / FEBS 2003;270(22):4469-77.
2003: Ilan Ifergan; Issac Meller; Josephine Issakov; Yehuda G Assaraf
Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity.
Cancer 2003;98(9):1958-66.
2003: Michal Stark; Lilah Rothem; Gerrit Jansen; George L Scheffer; I David Goldman; Yehuda G Assaraf
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
Molecular pharmacology 2003;64(2):220-7.
2003: Lilah Rothem; Ami Aronheim; Yehuda G Assaraf
Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.
The Journal of biological chemistry 2003;278(11):8935-41.
2003: Jan Hendrik Hooijberg; Godefridus J Peters; Yehuda G Assaraf; Ietje Kathmann; David G Priest; Marlene A Bunni; Anjo J P Veerman; George L Scheffer; G J L Kaspers; Gerrit Jansen
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Biochemical pharmacology 2003;65(5):765-71.
2003: Yehuda G Assaraf; Lilah Rothem; Jan Hendrik Hooijberg; Michal Stark; Ilan Ifergan; Ietje Kathmann; B A C Dijkmans; Godefridus J Peters; Gerrit Jansen
Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.
The Journal of biological chemistry 2003;278(9):6680-6.
2003: Esti Liani; Lilah Rothem; Marlene A Bunni; Clyde Smith; Gerrit Jansen; Yehuda G Assaraf
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
International journal of cancer. Journal international du cancer 2003;103(5):587-99.
2002: Lilah Rothem; Ilan Ifergan; Yotam Kaufman; David G Priest; Gerrit Jansen; Yehuda G Assaraf
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines.
The Biochemical journal 2002;367(Pt 3):741-50.
2002: Dana Baron; Yehuda G Assaraf; Nadine Cohen; Ami Aronheim
Lack of plasma membrane targeting of a G172D mutant thiamine transporter derived from Rogers syndrome family.
Molecular medicine (Cambridge, Mass.) 2002;8(8):462-74.
2002: Robert Mauritz; Godefridus J Peters; David G Priest; Yehuda G Assaraf; Stavit Drori; Ietje Kathmann; Paul Noordhuis; Marlene A Bunni; Andre Rosowsky; Jan H Schornagel; HERBERT PINEDO; Gerrit Jansen
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Biochemical pharmacology 2002;63(2):105-15.
2001: Revital Niv; Yehuda G Assaraf; Dina Segal; E Pirak; Yoram Reiter
Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein.
International journal of cancer. Journal international du cancer 2001;94(6):864-72.
2000: Stavit Drori; Gerrit Jansen; Robert Mauritz; Godefridus J Peters; Yehuda G Assaraf
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
The Journal of biological chemistry 2000;275(40):30855-63.
2000: Stavit Drori; Hannah Sprecher; G Shemer; Gerrit Jansen; I David Goldman; Yehuda G Assaraf
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
European journal of biochemistry / FEBS 2000;267(3):690-702.
1999: Gerrit Jansen; Godefridus J Peters; HERBERT PINEDO; David G Priest; Yehuda G Assaraf
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Journal of the National Cancer Institute 1999;91(23):2047-50.
1999: Yehuda G Assaraf; EE Sierra; Solomon Babani; I David Goldman
Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters.
Biochemical pharmacology 1999;58(8):1321-7.
1999: Jan Hendrik Hooijberg; Henk J Broxterman; Marcel Kool; Yehuda G Assaraf; Godefridus J Peters; Paul Noordhuis; Rik J Scheper; Piet Borst; HERBERT PINEDO; Gerrit Jansen
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Cancer research 1999;59(11):2532-5.
1999: Gerrit Jansen; H Barr; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Godefridus J Peters; Yehuda G Assaraf
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
Molecular pharmacology 1999;55(4):761-9.
1999: Ronit Regev; Yehuda G Assaraf; Gera D Eytan
Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells.
European journal of biochemistry / FEBS 1999;259(1-2):18-24.
1998: Eli Sprecher; Reuven Bergman; Hannah Sprecher; Gila Maor; Irena Reiter; Norberto Krivoy; Stavit Drori; Yehuda G Assaraf; Rachel Friedman-Birnbaum
Reduced folate carrier (RFC-1) gene expression in normal and psoriatic skin.
Archives of dermatological research 1998;290(12):656-60.
1998: Gerrit Jansen; Robert Mauritz; Stavit Drori; Hannah Sprecher; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Jan H Schornagel; HERBERT PINEDO; Godefridus J Peters; Yehuda G Assaraf
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
The Journal of biological chemistry 1998;273(46):30189-98.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
The Journal of biological chemistry 1998;273(30):19065-71.
1998: Eli Sprecher; Reuven Bergman; Hannah Sprecher; Gila Maor; Irena Reiter; Norberto Krivoy; Stavit Drori; Yehuda G Assaraf; Rachel Friedman-Birnbaum
The reduced folate carrier (RFC-1) gene is expressed in the murine epidermis.
Archives of dermatological research 1998;290(7):394-6.
1998: Yehuda G Assaraf; Solomon Babani; I David Goldman
Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells.
The Journal of biological chemistry 1998;273(14):8106-11.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.
The Journal of biological chemistry 1998;273(14):7873-9.
1997: Gera D Eytan; Ronit Regev; G Oren; C D Hurwitz; Yehuda G Assaraf
Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate.
European journal of biochemistry / FEBS 1997;248(1):104-12.
1997: Yehuda G Assaraf; I David Goldman
Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells.
The Journal of biological chemistry 1997;272(28):17460-6.
1997: Gerrit Jansen; Robert Mauritz; Yehuda G Assaraf; Hannah Sprecher; Stavit Drori; Ietje Kathmann; G R Westerhof; David G Priest; Marlene A Bunni; HERBERT PINEDO; Jan H Schornagel; Godefridus J Peters
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Advances in enzyme regulation 1997;37():59-76.
1996: Gera D Eytan; Ronit Regev; G Oren; Yehuda G Assaraf
The role of passive transbilayer drug movement in multidrug resistance and its modulation.
The Journal of biological chemistry 1996;271(22):12897-902.
1996: Gera D Eytan; Ronit Regev; Yehuda G Assaraf
Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis.
The Journal of biological chemistry 1996;271(6):3172-8.
1996: M J Borgnia; Gera D Eytan; Yehuda G Assaraf
Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
The Journal of biological chemistry 1996;271(6):3163-71.
1995: H Sprecher; H M Barr; J I Slotky; M Tzukerman; Gera D Eytan; Yehuda G Assaraf
Alteration of mitochondrial gene expression and disruption of respiratory function by the lipophilic antifolate pyrimethamine in mammalian cells.
The Journal of biological chemistry 1995;270(35):20668-76.
1995: Stavit Drori; Gera D Eytan; Yehuda G Assaraf
Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability.
European journal of biochemistry / FEBS 1995;228(3):1020-9.
1994: Gera D Eytan; M J Borgnia; Ronit Regev; Yehuda G Assaraf
Transport of polypeptide ionophores into proteoliposomes reconstituted with rat liver P-glycoprotein.
The Journal of biological chemistry 1994;269(42):26058-65.
1994: Yehuda G Assaraf; M J Borgnia
Probing the interaction of the multidrug-resistance phenotype with the polypeptide ionophore gramicidin D via functional channel formation.
European journal of biochemistry / FEBS 1994;222(3):813-24.
1994: Yehuda G Assaraf; Stavit Drori; Uriel Bachrach; V Shaugan-Labay
Determination of multidrug resistance levels in cultured mammalian cells using ornithine decarboxylase activity.
Analytical biochemistry 1994;216(1):97-109.
1993: Yehuda G Assaraf
Characterization by flow cytometry and fluorescein-methotrexate labeling of hydrophilic and lipophilic antifolate resistance in cultured mammalian cells.
Anti-cancer drugs 1993;4(5):535-44.
1993: Yehuda G Assaraf; M J Borgnia
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Anti-cancer drugs 1993;4(3):395-406.
1993: Yehuda G Assaraf; J I Slotky
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
The Journal of biological chemistry 1993;268(6):4556-66.
1988: Yehuda G Assaraf; C Kahana; D T Spira; Uriel Bachrach
Plasmodium falciparum: purification, properties, and immunochemical study of ornithine decarboxylase, the key enzyme in polyamine biosynthesis.
Experimental parasitology 1988;67(1):20-30.
1988: Uriel Bachrach; L Abu-Elheiga; Yehuda G Assaraf; Jacob Golenser; D T Spira
Polyamines in the cell cycle of the malarial parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1988;250():643-50.
1987: Yehuda G Assaraf; L Abu-Elheiga; D T Spira; H Desser; Uriel Bachrach
Effect of polyamine depletion on macromolecular synthesis of the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes.
The Biochemical journal 1987;242(1):221-6.
1987: Yehuda G Assaraf; Jacob Golenser; D T Spira; G Messer; Uriel Bachrach
Cytostatic effect of DL-alpha-difluoromethylornithine against Plasmodium falciparum and its reversal by diamines and spermidine.
Parasitology research 1987;73(4):313-8.
1986: D M Morgan; Uriel Bachrach; Yehuda G Assaraf; E Harari; Jacob Golenser
The effect of purified aminoaldehydes produced by polyamine oxidation on the development in vitro of Plasmodium falciparum in normal and glucose-6-phosphate-dehydrogenase-deficient erythrocytes.
The Biochemical journal 1986;236(1):97-101.
1986: Yehuda G Assaraf; Jacob Golenser; D T Spira; Uriel Bachrach
Plasmodium falciparum: synchronization of cultures with DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Experimental parasitology 1986;61(2):229-35.
1984: Yehuda G Assaraf; Jacob Golenser; D T Spira; Uriel Bachrach
Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparum.
The Biochemical journal 1984;222(3):815-9.