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Vincent Hilser

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Occupations

Thermodynamics

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Chemicals & Drugs

Physiology

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Publications

TOP 3
W Austin Elam; Andrew J Campagnolo; Travis P Schrank; Vincent J Hilser
Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites.
W Austin Elam; Andrew J Campagnolo; Travis P Schrank; Vincent J Hilser
Temperature and urea have opposing impacts on polyproline II conformational bias.
Hesam N Motlagh; E Brad Thompson; Jing Li; Vincent J Hilser
Interplay between allostery and intrinsic disorder in an ensemble.

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All Publications

2013: W Austin Elam; Andrew J Campagnolo; Travis P Schrank; Vincent J Hilser
Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites.
Protein science : a publication of the Protein Society 2013;22(4):405-17.
2013: W Austin Elam; Andrew J Campagnolo; Travis P Schrank; Vincent J Hilser
Temperature and urea have opposing impacts on polyproline II conformational bias.
Biochemistry 2013;52(5):949-58.
2012: Hesam N Motlagh; E Brad Thompson; Jing Li; Vincent J Hilser
Interplay between allostery and intrinsic disorder in an ensemble.
Biochemical Society transactions 2012;40(5):975-80.
2012: Jing Li; Hesam N Motlagh; E Brad Thompson; Carolyn Chakuroff; Vincent J Hilser
Thermodynamic dissection of the intrinsically disordered N-terminal domain of human glucocorticoid receptor.
The Journal of biological chemistry 2012;287(32):26777-87.
2012: Yinan Fu; Vincent J Hilser; Vignesh Kasinath; Veronica R Moorman; Nathaniel V Nucci; A Joshua Wand
Coupled motion in proteins revealed by pressure perturbation.
Journal of the American Chemical Society 2012;134(20):8543-50.
2012: Hesam N Motlagh; Vincent J Hilser
Agonism/antagonism switching in allosteric ensembles.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(11):4134-9.
2012: Vincent J Hilser; James O Wrabl; Hesam N Motlagh
Structural and energetic basis of allostery.
Annual review of biophysics 2012;41():585-609.
2011: Vincent J Hilser; E Brad Thompson
Structural dynamics, intrinsic disorder, and allostery in nuclear receptors as transcription factors.
The Journal of biological chemistry 2011;286(46):39675-82.
2011: James O Wrabl; Jenny Gu; Tong Liu; Travis P Schrank; Steven T Whitten; Vincent J Hilser
The role of protein conformational fluctuations in allostery, function, and evolution.
Biophysical chemistry 2011;159(1):129-41.
2011: Vincent J Hilser
Structural biology: Finding the wet spots.
Nature 2011;469(7329):166-7.
2011: Travis P Schrank; W Austin Elam; Jing Li; Vincent J Hilser
Strategies for the thermodynamic characterization of linked binding/local folding reactions within the native state application to the LID domain of adenylate kinase from Escherichia coli.
Methods in enzymology 2011;492():253-82.
2010: James O Wrabl; Vincent J Hilser
Investigating homology between proteins using energetic profiles.
PLoS computational biology 2010;6(3):e1000722.
2010: Vincent J Hilser
Biochemistry. An ensemble view of allostery.
Science (New York, N.Y.) 2010;327(5966):653-4.
2009: Travis P Schrank; David Bolen; Vincent J Hilser
Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):16984-9.
2009: Jenny Gu; Vincent J Hilser
Sequence-based analysis of protein energy landscapes reveals nonuniform thermal adaptation within the proteome.
Molecular biology and evolution 2009;26(10):2217-27.
2009: Jason Vertrees; James O Wrabl; Vincent J Hilser
An energetic representation of protein architecture that is independent of primary and secondary structure.
Biophysical journal 2009;97(5):1461-70.
2009: Anthony Manson; Steven T Whitten; Josephine C Ferreon; Robert Fox; Vincent J Hilser
Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity.
Journal of the American Chemical Society 2009;131(19):6785-93.
2009: Jason Vertrees; James O Wrabl; Vincent J Hilser
Energetic profiling of protein folds.
Methods in enzymology 2009;455():299-327.
2008: Jenny Gu; Vincent J Hilser
Predicting the energetics of conformational fluctuations in proteins from sequence: a strategy for profiling the proteome.
Structure (London, England : 1993) 2008;16(11):1627-37.
2008: Suwei Wang; Jenny Gu; Scott A Larson; Steven T Whitten; Vincent J Hilser
Denatured-state energy landscapes of a protein structural database reveal the energetic determinants of a framework model for folding.
Journal of molecular biology 2008;381(5):1184-201.
2008: Steven T Whitten; Huan-Wang Yang; Robert Fox; Vincent J Hilser
Exploring the impact of polyproline II (PII) conformational bias on the binding of peptides to the SEM-5 SH3 domain.
Protein science : a publication of the Protein Society 2008;17(7):1200-11.
2008: Kemal Sayar; Ozlem Uğur; Tong Liu; Vincent J Hilser; Ongun Onaran
Exploring allosteric coupling in the alpha-subunit of heterotrimeric G proteins using evolutionary and ensemble-based approaches.
BMC structural biology 2008;8():23.
2008: Steven T Whitten; Bertrand E García-Moreno; Vincent J Hilser
Ligand effects on the protein ensemble: unifying the descriptions of ligand binding, local conformational fluctuations, and protein stability.
Methods in cell biology 2008;84():871-91.
2007: Vincent J Hilser; E Brad Thompson
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8311-5.
2007: Tong Liu; Steven T Whitten; Vincent J Hilser
Functional residues serve a dominant role in mediating the cooperativity of the protein ensemble.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4347-52.
2006: Steven T Whitten; Andrew J Kurtz; Maxim S Pometun; A Joshua Wand; Vincent J Hilser
Revealing the nature of the native state ensemble through cold denaturation.
Biochemistry 2006;45(34):10163-74.
2006: Vincent J Hilser; Bertrand García-Moreno E; Terrence G Oas; Greg Kapp; Steven T Whitten
A statistical thermodynamic model of the protein ensemble.
Chemical reviews 2006;106(5):1545-58.
2006: Carolyn Fitch; Steven T Whitten; Vincent J Hilser; Bertrand García-Moreno E
Molecular mechanisms of pH-driven conformational transitions of proteins: insights from continuum electrostatics calculations of acid unfolding.
Proteins 2006;63(1):113-26.
2006: Tong Liu; Steven T Whitten; Vincent J Hilser
Ensemble-based signatures of energy propagation in proteins: a new view of an old phenomenon.
Proteins 2006;62(3):728-38.
2005: Jason Vertrees; Phillip Barritt; Steven T Whitten; Vincent J Hilser
COREX/BEST server: a web browser-based program that calculates regional stability variations within protein structures.
Bioinformatics (Oxford, England) 2005;21(15):3318-9.
2005: Steven T Whitten; Bertrand García-Moreno E; Vincent J Hilser
Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4282-7.
2004: Josephine C Ferreon; James Hamburger; Vincent J Hilser
An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange.
Journal of the American Chemical Society 2004;126(40):12774-5.
2004: James Hamburger; Josephine C Ferreon; Steven T Whitten; Vincent J Hilser
Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins.
Biochemistry 2004;43(30):9790-9.
2004: Scott A Larson; Vincent J Hilser
Analysis of the "thermodynamic information content" of a Homo sapiens structural database reveals hierarchical thermodynamic organization.
Protein science : a publication of the Protein Society 2004;13(7):1787-801.
2004: Josephine C Ferreon; Vincent J Hilser
Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation.
Biochemistry 2004;43(24):7787-97.
2004: Charles R Babu; Vincent J Hilser; A Joshua Wand
Direct access to the cooperative substructure of proteins and the protein ensemble via cold denaturation.
Nature structural & molecular biology 2004;11(4):352-7.
2004: Monique R Ferguson; Xiuzhen Fan; Munia Mukherjee; Jinquan Luo; Raza Khan; Josephine C Ferreon; Vincent J Hilser; Robert E Shope; Robert Fox
Directed discovery of bivalent peptide ligands to an SH3 domain.
Protein science : a publication of the Protein Society 2004;13(3):626-32.
2003: Josephine C Ferreon; David Volk; Bruce A Luxon; David Gorenstein; Vincent J Hilser
Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain.
Biochemistry 2003;42(19):5582-91.
2003: Josephine C Ferreon; Vincent J Hilser
Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling.
Protein science : a publication of the Protein Society 2003;12(5):982-96.
2003: Josephine C Ferreon; Vincent J Hilser
The effect of the polyproline II (PPII) conformation on the denatured state entropy.
Protein science : a publication of the Protein Society 2003;12(3):447-57.
2002: James O Wrabl; Scott A Larson; Vincent J Hilser
Thermodynamic environments in proteins: fundamental determinants of fold specificity.
Protein science : a publication of the Protein Society 2002;11(8):1945-57.
2001: Steven T Whitten; JO Wooll; R Razeghifard; Bertrand García-Moreno E; Vincent J Hilser
The origin of pH-dependent changes in m-values for the denaturant-induced unfolding of proteins.
Journal of molecular biology 2001;309(5):1165-75.
2001: James O Wrabl; Scott A Larson; Vincent J Hilser
Thermodynamic propensities of amino acids in the native state ensemble: implications for fold recognition.
Protein science : a publication of the Protein Society 2001;10(5):1032-45.
2001: Vincent J Hilser
Modeling the native state ensemble.
Methods in molecular biology (Clifton, N.J.) 2001;168():93-116.
2000: H Pan; J C Lee; Vincent J Hilser
Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12020-5.
2000: JO Wooll; James O Wrabl; Vincent J Hilser
Ensemble modulation as an origin of denaturant-independent hydrogen exchange in proteins.
Journal of molecular biology 2000;301(2):247-56.
1998: Vincent J Hilser; David Wesley Dowdy; Terrence G Oas; Ernesto Freire
The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9903-8.
1997: Vincent J Hilser; B D Townsend; Ernesto Freire
Structure-based statistical thermodynamic analysis of T4 lysozyme mutants: structural mapping of cooperative interactions.
Biophysical chemistry 1997;64(1-3):69-79.
1997: Vincent J Hilser; Ernesto Freire
Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease.
Proteins 1997;27(2):171-83.
1996: Vincent J Hilser; Ernesto Freire
Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.
Journal of molecular biology 1996;262(5):756-72.
1996: Vincent J Hilser; J Gómez; Ernesto Freire
The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations.
Proteins 1996;26(2):123-33.
1996: J A D'Aquino; J Gómez; Vincent J Hilser; K H Lee; Mario Amzel; Ernesto Freire
The magnitude of the backbone conformational entropy change in protein folding.
Proteins 1996;25(2):143-56.
1995: J Gómez; Vincent J Hilser; D Xie; Ernesto Freire
The heat capacity of proteins.
Proteins 1995;22(4):404-12.
1995: Vincent J Hilser; Ernesto Freire
Quantitative analysis of conformational equilibrium using capillary electrophoresis: applications to protein folding.
Analytical biochemistry 1995;224(2):465-85.
1994: S E Rudnick; Vincent J Hilser; G D Worosila
Comparison of the utility of capillary zone electrophoresis and high-performance liquid chromatography in peptide mapping and separation.
Journal of chromatography. A 1994;672(1-2):219-29.
1993: Vincent J Hilser; G D Worosila; S E Rudnick
Protein and peptide mobility in capillary zone electrophoresis. A comparison of existing models and further analysis.
Journal of chromatography 1993;630(1-2):329-36.
1993: Vincent J Hilser; G D Worosila; Ernesto Freire
Analysis of thermally induced protein folding/unfolding transitions using free solution capillary electrophoresis.
Analytical biochemistry 1993;208(1):125-31.