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Douglas Hilton

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Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
Huei San Leong; Ian J Majewski; James M Murphy; Miha Pakusch; Gordon K Smyth; Kelan Chen; Jason Corbin; Douglas J Hilton; Yifang Hu; Stanley Lee; Warren S Alexander; Marnie E Blewitt
Epigenetic regulator Smchd1 functions as a tumor suppressor.
Seth L Masters; Kate McArthur; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Marc Pellegrini; Simon Preston; Warren S Alexander; Tracey M Baldwin; Louise H Cengia; Stephane Chevrier; Janelle E Collinge; Lionel Feigenbaum; Motti Gerlic; Katya J Henley; Douglas J Hilton; Daniel L Kastner; Benjamin T Kile; Ben A Croker
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

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2013: Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
The Biochemical journal 2013;451(2):165-75.
2013: Huei San Leong; Ian J Majewski; James M Murphy; Miha Pakusch; Gordon K Smyth; Kelan Chen; Jason Corbin; Douglas J Hilton; Yifang Hu; Stanley Lee; Warren S Alexander; Marnie E Blewitt
Epigenetic regulator Smchd1 functions as a tumor suppressor.
Cancer research 2013;73(5):1591-9.
2012: Seth L Masters; Kate McArthur; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Marc Pellegrini; Simon Preston; Warren S Alexander; Tracey M Baldwin; Louise H Cengia; Stephane Chevrier; Janelle E Collinge; Lionel Feigenbaum; Motti Gerlic; Katya J Henley; Douglas J Hilton; Daniel L Kastner; Benjamin T Kile; Ben A Croker
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Immunity 2012;37(6):1009-23.
2011: Ashley Ng; Gordon K Smyth; Carolyn A de Graaf; Douglas J Hilton; Yifang Hu; Craig D Hyland; Benjamin T Kile; Stephen J Loughran; Donald Metcalf; Warren S Alexander
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.
Blood 2011;118(9):2454-61.
2011: Matthew D Young; Marnie E Blewitt; Douglas J Hilton; Alicia Oshlack; Evelyn Trounson; Matthew J Wakefield; Tracy A Willson; Ian J Majewski
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity.
Nucleic acids research 2011;39(17):7415-27.
2011: Nhu-Y N Nguyen; Mhairi J Maxwell; Lisa M Ooms; Elizabeth M Davies; Adrienne A Hilton; Janelle E Collinge; Douglas J Hilton; Benjamin T Kile; Christina A Mitchell; Margaret L Hibbs; Stephen M Jane; David J Curtis
An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.
Blood 2011;117(20):5362-71.
2011: Samir Taoudi; Thomas Bee; Adrienne Hilton; Kathy Knezevic; Julie Scott; Tracy A Willson; Caitlin Collin; Tim Thomas; Anne K Voss; Benjamin T Kile; Warren S Alexander; John E Pimanda; Douglas J Hilton
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.
Genes & development 2011;25(3):251-62.
2010: Kylie T Greig; Carolyn A de Graaf; James M Murphy; Marina R Carpinelli; Swee Heng Milon Pang; Jon Frampton; Benjamin T Kile; Douglas J Hilton; Stephen L Nutt
Critical roles for c-Myb in lymphoid priming and early B-cell development.
Blood 2010;115(14):2796-805.
2010: Wei Shi; Carolyn A de Graaf; Sarah A Kinkel; Ariel H Achtman; Tracey Baldwin; Louis Schofield; Hamish S Scott; Douglas J Hilton; Gordon K Smyth
Estimating the proportion of microarray probes expressed in an RNA sample.
Nucleic acids research 2010;38(7):2168-76.
2010: James M Murphy; Donald Metcalf; Ian G Young; Douglas J Hilton
A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.
Growth factors (Chur, Switzerland) 2010;28(2):104-10.
2009: Hiu Kiu; Christopher J Greenhalgh; Anne Thaus; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.
Growth factors (Chur, Switzerland) 2009;27(6):384-93.
2009: Elizabeth A Kruse; Stephen J Loughran; Tracey M Baldwin; Emma C Josefsson; Sarah Ellis; Dennis Watson; Paquita Nurden; Donald Metcalf; Douglas J Hilton; Warren S Alexander; Benjamin T Kile
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13814-9.
2008: Stephen J Loughran; Elizabeth A Kruse; Douglas F Hacking; Carolyn A de Graaf; Craig D Hyland; Tracy A Willson; Katya J Henley; Sarah Ellis; Anne K Voss; Donald Metcalf; Douglas J Hilton; Warren S Alexander; Benjamin T Kile
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
Nature immunology 2008;9(7):810-9.
2008: Ben A Croker; Lisa A Mielke; Samuel Wormald; Donald Metcalf; Hiu Kiu; Warren S Alexander; Douglas J Hilton; Andrew W Roberts
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
Experimental hematology 2008;36(7):786-98.
2008: Marnie E Blewitt; Anne-Valerie Gendrel; Zhenyi Pang; Duncan B Sparrow; Nadia Whitelaw; Jeffrey M Craig; Anwyn Apedaile; Douglas J Hilton; Sally L Dunwoodie; Neil Brockdorff; Graham F Kay; Emma Whitelaw
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.
Nature genetics 2008;40(5):663-9.
2008: Hayley A Croom; David J Izon; Mark M Chong; David J Curtis; Andrew W Roberts; Thomas W H Kay; Douglas J Hilton; Warren S Alexander; Robyn Starr
Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.
Molecular immunology 2008;45(10):2888-96.
2008: Ian J Majewski; Marnie E Blewitt; Carolyn A de Graaf; Edward J McManus; Melanie Bahlo; Adrienne A Hilton; Craig D Hyland; Gordon K Smyth; Jason E Corbin; Donald Metcalf; Warren S Alexander; Douglas J Hilton
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
PLoS biology 2008;6(4):e93.
2008: Ian Smyth; Douglas F Hacking; Adrienne A Hilton; Nigora Mukhamedova; Peter J Meikle; Sarah Ellis; Keith Satterley; Keith Slattery; Janelle E Collinge; Carolyn A de Graaf; Melanie Bahlo; Dmitri Sviridov; Benjamin T Kile; Douglas J Hilton
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.
PLoS genetics 2008;4(9):e1000192.
2007: Elena Tucker; Kristy O'Donnell; Martina Fuchsberger; Adrienne A Hilton; Donald Metcalf; Kylie Greig; Natalie Sims; Julian M W Quinn; Warren S Alexander; Douglas J Hilton; Benjamin T Kile; David M Tarlinton; Robyn Starr
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7514-22.
2007: Hiu Kiu; Douglas J Hilton; Nicos A Nicola; Matthias Ernst; Rodolfo Marquez; Warren S Alexander; Andrew W Roberts; Edward J McManus
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha.
Growth factors (Chur, Switzerland) 2007;25(5):319-28.
2007: Christine Brender; Gillian M Tannahill; Brendan J Jenkins; Joel Fletcher; Ruth Columbus; Christiaan J M Saris; Matthias Ernst; Nicos A Nicola; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Blood 2007;110(7):2528-36.
2007: Kristy Boyle; Paul J Egan; Steven Rakar; Tracy A Willson; Ian P Wicks; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts; Lorraine Robb
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
Blood 2007;110(5):1466-74.
2007: Kylie T Greig; Jennifer Antonchuk; Donald Metcalf; Phillip O Morgan; Danielle L Krebs; Jian-Guo Zhang; Douglas F Hacking; Lars Bode; Lorraine Robb; Christian Kranz; Carolyn de Graaf; Melanie Bahlo; Nicos A Nicola; Stephen L Nutt; Hudson H Freeze; Warren S Alexander; Douglas J Hilton; Benjamin T Kile
Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development.
Molecular and cellular biology 2007;27(16):5849-59.
2007: Trevor Huyton; Jian-Guo Zhang; Cindy S Luo; Mei-Zhen Lou; Douglas J Hilton; Nicos A Nicola; Thomas P J Garrett
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12737-42.
2007: Marlyse A Debrincat; Jian-Guo Zhang; Tracy A Willson; John Silke; Lisa M Connolly; Richard J Simpson; Warren S Alexander; Nicos A Nicola; Benjamin T Kile; Douglas J Hilton
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.
The Journal of biological chemistry 2007;282(7):4728-37.
2007: Jeremy D Silver; Douglas J Hilton; Melanie Bahlo; Benjamin T Kile
Probabilistic analysis of recessive mutagenesis screen strategies.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(1):5-22.
2007: Samuel Wormald; Douglas J Hilton
The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways.
Current opinion in hematology 2007;14(1):9-15.
2006: Karim C El Kasmi; Jeff Holst; Maryaline Coffre; Lisa A Mielke; Antoine de Pauw; Nouara Lhocine; Amber M Smith; Robert Rutschman; Deepak Kaushal; Yuhong Shen; Takashi Suda; Raymond P Donnelly; Martin G Myers Jr; Warren Alexander; Dario A A Vignali; Stephanie S Watowich; Matthias Ernst; Douglas J Hilton; Peter J Murray
General nature of the STAT3-activated anti-inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7880-8.
2006: Warren S Alexander; Elizabeth M Viney; Jian-Guo Zhang; Donald Metcalf; Maria Kauppi; Craig D Hyland; Marina R Carpinelli; William Stevenson; Ben A Croker; Adrienne A Hilton; Sarah Ellis; Carly Selan; Harshal H Nandurkar; Christopher C Goodnow; Benjamin T Kile; Nicos A Nicola; Andrew W Roberts; Douglas J Hilton
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16442-7.
2006: Ian J Majewski; Donald Metcalf; Lisa A Mielke; Danielle L Krebs; Sarah Ellis; Marina R Carpinelli; Sandra Mifsud; Ladina Di Rago; Jason Corbin; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14146-51.
2006: jeffrey babon; Edward J McManus; Shenggen Yao; David P DeSouza; Lisa A Mielke; Naomi S Sprigg; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Manuel Baca; Sandra E Nicholson; Raymond S Norton
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Molecular cell 2006;22(2):205-16.
2006: Samuel Wormald; Jian-Guo Zhang; Danielle L Krebs; Lisa A Mielke; Jeremy Silver; Warren S Alexander; Terence P Speed; Nicos A Nicola; Douglas J Hilton
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling.
The Journal of biological chemistry 2006;281(16):11135-43.
2006: Ashley Mansell; Rosealee Smith; Sarah L Doyle; Pearl Gray; Jennifer E Fenner; Peter J Crack; Sandra E Nicholson; Douglas J Hilton; Luke A J O'Neill; Paul J Hertzog
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Nature immunology 2006;7(2):148-55.
2006: Samuel Wormald; Douglas J Hilton; Gordon K Smyth; Terence P Speed
Proximal genomic localization of STAT1 binding and regulated transcriptional activity.
BMC genomics 2006;7():254.
2006: Jennifer E Fenner; Robyn Starr; Ann L Cornish; Jian-Guo Zhang; Donald Metcalf; Robert D Schreiber; Kathleen Sheehan; Douglas J Hilton; Warren S Alexander; Paul J Hertzog
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
Nature immunology 2006;7(1):33-9.
2005: Benjamin T Kile; Douglas J Hilton
The art and design of genetic screens: mouse.
Nature reviews. Genetics 2005;6(7):557-67.
2005: Donald Metcalf; Marina R Carpinelli; Craig D Hyland; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.
Blood 2005;105(9):3480-7.
2005: Elizabeth Rico-Bautista; Christopher J Greenhalgh; Petra Tollet-Egnell; Douglas J Hilton; Warren S Alexander; Gunnar Norstedt; Amilcar Flores-Morales
Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.
Molecular endocrinology (Baltimore, Md.) 2005;19(3):781-93.
2005: Sandra E Nicholson; Donald Metcalf; Naomi S Sprigg; Ruth Columbus; Francesca Walker; Anabel Silva; Dale Cary; Tracy A Willson; Jian-Guo Zhang; Douglas J Hilton; Warren S Alexander; Nicos A Nicola
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2328-33.
2005: Christopher J Greenhalgh; Elizabeth Rico-Bautista; Mattias Lorentzon; Anne L Thaus; Phillip O Morgan; Tracy A Willson; Panagiota Zervoudakis; Donald Metcalf; Ian Street; Nicos A Nicola; Andrew D Nash; Louis J Fabri; Gunnar Norstedt; Claes Ohlsson; Amilcar Flores-Morales; Warren S Alexander; Douglas J Hilton
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
The Journal of clinical investigation 2005;115(2):397-406.
2004: Danielle L Krebs; Donald Metcalf; Tobias Merson; Anne K Voss; Tim Thomas; Jian-Guo Zhang; Steven Rakar; Moira K O'Bryan; Tracy A Willson; Elizabeth M Viney; Lisa A Mielke; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Development of hydrocephalus in mice lacking SOCS7.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15446-51.
2004: Jennifer Antonchuk; Craig D Hyland; Douglas J Hilton; Warren S Alexander
Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors.
Blood 2004;104(5):1306-13.
2004: Christine Brender; Ruth Columbus; Donald Metcalf; Emanuela Handman; Robyn Starr; Nick Huntington; David M Tarlinton; Niels Ødum; Sandra E Nicholson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
Molecular and cellular biology 2004;24(13):6094-103.
2004: Marina R Carpinelli; Douglas J Hilton; Donald Metcalf; Jennifer Antonchuk; Craig D Hyland; Sandra Mifsud; Ladina Di Rago; Adrienne A Hilton; Tracy A Willson; Andrew W Roberts; Robert G Ramsay; Nicos A Nicola; Warren S Alexander
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6553-8.
2004: Ben A Croker; Donald Metcalf; Lorraine Robb; Wei Wei; Sandra Mifsud; Ladina DiRago; Leonie A Cluse; Kate D Sutherland; Lynne Hartley; Emily Williams; Jian-Guo Zhang; Douglas J Hilton; Nicos A Nicola; Warren S Alexander; Andrew W Roberts
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Immunity 2004;20(2):153-65.
2004: Samuel Wormald; Douglas J Hilton
Inhibitors of cytokine signal transduction.
The Journal of biological chemistry 2004;279(2):821-4.
2004: Warren S Alexander; Douglas J Hilton
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.
Annual review of immunology 2004;22():503-29.
2003: Robyn Starr; Douglas J Hilton
Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1.
Immunity 2003;19(3):308-9.
2003: Ann L Cornish; Mark M W Chong; Gayle M Davey; Rima Darwiche; Nicos A Nicola; Douglas J Hilton; Thomas W H Kay; Robyn Starr; Warren S Alexander
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.
The Journal of biological chemistry 2003;278(25):22755-61.
2003: Ben A Croker; Danielle L Krebs; Jian-Guo Zhang; Samuel Wormald; Tracy A Willson; Edouard G Stanley; Lorraine Robb; Christopher J Greenhalgh; Irmgard Förster; Björn E Clausen; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Andrew W Roberts; Warren S Alexander
SOCS3 negatively regulates IL-6 signaling in vivo.
Nature immunology 2003;4(6):540-5.
2003: Minda Sarna; Evan Ingley; Samantha J Busfield; Vanessa S Cull; Winald Lepere; David J McCarthy; Michael J Wright; Gene A Palmer; David Chappell; Milly S Sayer; Warren S Alexander; Douglas J Hilton; Robyn Starr; Stephanie S Watowich; Thomas Bittorf; S Peter Klinken; Peta A Tilbrook
Differential regulation of SOCS genes in normal and transformed erythroid cells.
Oncogene 2003;22(21):3221-30.
2003: Mark M W Chong; Ann L Cornish; Rima Darwiche; Edouard G Stanley; Jared F Purton; Dale I Godfrey; Douglas J Hilton; Robyn Starr; Warren S Alexander; Thomas W H Kay
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.
Immunity 2003;18(4):475-87.
2003: Danielle L Krebs; Douglas J Hilton
A new role for SOCS in insulin action. Suppressor of cytokine signaling.
Science's STKE : signal transduction knowledge environment 2003;2003(169):PE6.
2003: Ann L Cornish; Gayle M Davey; Donald Metcalf; Jared F Purton; Jason E Corbin; Christopher J Greenhalgh; Rima Darwiche; Li Wu; Nicos A Nicola; Dale I Godfrey; William R Heath; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):878-86.
2002: Christopher J Greenhalgh; Megan E Miller; Douglas J Hilton; P Kay Lund
Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease.
Gastroenterology 2002;123(6):2064-81.
2002: Joanne L Eyles; Donald Metcalf; Michael J Grusby; Douglas J Hilton; Robyn Starr
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.
The Journal of biological chemistry 2002;277(46):43735-40.
2002: Marina R Carpinelli; Ian P Wicks; Natalie Sims; Kristy O'Donnell; Katherine Hanzinikolas; Rachel Burt; Simon J Foote; Melanie Bahlo; Warren S Alexander; Douglas J Hilton
An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets.
The American journal of pathology 2002;161(5):1925-33.
2002: Christopher J Greenhalgh; Donald Metcalf; Anne L Thaus; Jason E Corbin; Rachel Uren; Phillip O Morgan; Louis J Fabri; Jian-Guo Zhang; Helene M Martin; Tracy A Willson; Nils Billestrup; Nicos A Nicola; Manuel Baca; Warren S Alexander; Douglas J Hilton
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
The Journal of biological chemistry 2002;277(43):40181-4.
2002: David P De Souza; Louis J Fabri; Andrew D Nash; Douglas J Hilton; Nicos A Nicola; Manuel Baca
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.
Biochemistry 2002;41(29):9229-36.
2002: Rachael Richardson; Robyn Starr; Leecia J L Angus; Douglas J Hilton
A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction.
The Journal of biological chemistry 2002;277(28):25624-30.
2002: Danielle L Krebs; Rachel Uren; Donald Metcalf; Steven Rakar; Jian-Guo Zhang; Robyn Starr; David P De Souza; Kathy Hanzinikolas; Jo Eyles; Lisa M Connolly; Richard J Simpson; Nicos A Nicola; Sandra E Nicholson; Manuel Baca; Douglas J Hilton; Warren S Alexander
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Molecular and cellular biology 2002;22(13):4567-78.
2002: Christopher J Greenhalgh; Patrick Bertolino; Sylvia Asa; Donald Metcalf; Jason E Corbin; Timothy E Adams; Helen W Davey; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b).
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1394-406.
2002: Benjamin T Kile; Brenda A Schulman; Warren S Alexander; Nicos A Nicola; Helene M Martin; Douglas J Hilton
The SOCS box: a tale of destruction and degradation.
Trends in biochemical sciences 2002;27(5):235-41.
2002: Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):943-8.
2001: Jian-Guo Zhang; Donald Metcalf; Steven Rakar; M Asimakis; Christopher J Greenhalgh; Tracy A Willson; Robyn Starr; Sandra E Nicholson; W Carter; Warren S Alexander; Douglas J Hilton; Nicos A Nicola
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13261-5.
2001: Christopher J Greenhalgh; Douglas J Hilton
Negative regulation of cytokine signaling.
Journal of leukocyte biology 2001;70(3):348-56.
2001: Benjamin T Kile; Donald Metcalf; Sandra Mifsud; Ladina DiRago; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Functional analysis of Asb-1 using genetic modification in mice.
Molecular and cellular biology 2001;21(18):6189-97.
2001: Andrew W Roberts; Lorraine Robb; Steven Rakar; Lynne Hartley; Leonie A Cluse; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Warren S Alexander
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9324-9.
2001: Geoffrey J Lindeman; Sergio Wittlin; H Lada; Matthew J Naylor; M Santamaria; Jian-Guo Zhang; Robyn Starr; Douglas J Hilton; Warren S Alexander; Christopher J Ormandy; Jane E Visvader
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Genes & development 2001;15(13):1631-6.
2001: M Brysha; Jian-Guo Zhang; P Bertolino; Jason E Corbin; Warren S Alexander; Nicos A Nicola; Douglas J Hilton; Robyn Starr
Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo.
The Journal of biological chemistry 2001;276(25):22086-9.
2001: Danielle L Krebs; Douglas J Hilton
SOCS proteins: negative regulators of cytokine signaling.
Stem cells (Dayton, Ohio) 2001;19(5):378-87.
2000: Benjamin T Kile; Elizabeth M Viney; Tracy A Willson; T C Brodnicki; Michael Cancilla; A S Herlihy; Ben A Croker; Manuel Baca; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.
Gene 2000;258(1-2):31-41.
2000: David J Curtis; Stephen M Jane; Douglas J Hilton; L Dougherty; David M Bodine; C Glenn Begley
Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest.
Experimental hematology 2000;28(11):1250-9.
2000: Danielle L Krebs; Douglas J Hilton
SOCS: physiological suppressors of cytokine signaling.
Journal of cell science 2000;113 ( Pt 16)():2813-9.
2000: Donald Metcalf; Christopher J Greenhalgh; Elizabeth M Viney; Tracy A Willson; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Gigantism in mice lacking suppressor of cytokine signalling-2.
Nature 2000;405(6790):1069-73.
2000: Sandra E Nicholson; David P De Souza; Louis J Fabri; Jason Corbin; Tracy A Willson; Jian-Guo Zhang; A Silva; M Asimakis; A Farley; Andrew D Nash; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6493-8.
2000: A Hammacher; J Wijdenes; Douglas J Hilton; Nicos A Nicola; Richard J Simpson; Judith E Layton
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.
The Biochemical journal 2000;345 Pt 1():25-32.
1999: Helen W Davey; Michael J McLachlan; Richard J Wilkins; Douglas J Hilton; T E Adams
STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver.
Molecular and cellular endocrinology 1999;158(1-2):111-6.
1999: Warren S Alexander; Robyn Starr; Donald Metcalf; Sandra E Nicholson; A Farley; Andrew G Elefanty; M Brysha; Benjamin T Kile; R Richardson; Manuel Baca; Jian-Guo Zhang; Tracy A Willson; Elizabeth M Viney; Naomi S Sprigg; Steven Rakar; Jason Corbin; Sandra Mifsud; Ladina DiRago; Dale Cary; Nicos A Nicola; Douglas J Hilton
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Journal of leukocyte biology 1999;66(4):588-92.
1999: Warren S Alexander; Robyn Starr; Jennifer E Fenner; Clare L Scott; Emanuela Handman; Naomi S Sprigg; Jason E Corbin; Ann L Cornish; Rima Darwiche; Catherine M Owczarek; Thomas W H Kay; Nicos A Nicola; Paul J Hertzog; Donald Metcalf; Douglas J Hilton
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Cell 1999;98(5):597-608.
1999: Warren S Alexander; Steven Rakar; Lorraine Robb; A Farley; Tracy A Willson; Jian-Guo Zhang; Lynne Hartley; Y Kikuchi; T Kojima; H Nomura; M Hasegawa; M Maeda; Louis J Fabri; K Jachno; Andrew D Nash; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
Current biology : CB 1999;9(11):605-8.
1999: Donald Metcalf; Warren S Alexander; Andrew G Elefanty; Nicos A Nicola; Douglas J Hilton; Robyn Starr; Sandra Mifsud; Ladina Di Rago
Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1.
Leukemia 1999;13(6):926-34.
1999: Jian-Guo Zhang; A Farley; Sandra E Nicholson; Tracy A Willson; L M Zugaro; Richard J Simpson; Robert L Moritz; Dale Cary; R Richardson; George Hausmann; B J Kile; S B Kent; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2071-6.
1999: Sandra E Nicholson; Tracy A Willson; A Farley; Robyn Starr; Jian-Guo Zhang; Manuel Baca; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The EMBO journal 1999;18(2):375-85.
1999: Nicos A Nicola; Sandra E Nicholson; Donald Metcalf; Jian-Guo Zhang; Manuel Baca; A Farley; Tracy A Willson; Robyn Starr; W Alexander; Douglas J Hilton
Negative regulation of cytokine signaling by the SOCS proteins.
Cold Spring Harbor symposia on quantitative biology 1999;64():397-404.
1999: R Starr; Douglas J Hilton
Negative regulation of the JAK/STAT pathway.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(1):47-52.
1998: Y Zhang; Tracy A Willson; Donald Metcalf; Dale Cary; Douglas J Hilton; R Clark; Nicos A Nicola
The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.
The Journal of biological chemistry 1998;273(51):34370-83.
1998: Robyn Starr; Donald Metcalf; Andrew G Elefanty; M Brysha; Tracy A Willson; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14395-9.
1998: Robyn Starr; Douglas J Hilton
SOCS: suppressors of cytokine signalling.
The international journal of biochemistry & cell biology 1998;30(10):1081-5.
1998: A Hammacher; Rachael Richardson; Judith E Layton; DK Smith; L J Angus; Douglas J Hilton; Nicos A Nicola; J Wijdenes; Richard J Simpson
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.
The Journal of biological chemistry 1998;273(35):22701-7.
1998: Sandra E Nicholson; Douglas J Hilton
The SOCS proteins: a new family of negative regulators of signal transduction.
Journal of leukocyte biology 1998;63(6):665-8.
1998: T E Adams; J A Hansen; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Nils Billestrup
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling.
The Journal of biological chemistry 1998;273(3):1285-7.
1998: Douglas J Hilton; Rachael Richardson; Warren S Alexander; Elizabeth M Viney; Tracy A Willson; Naomi S Sprigg; Robyn Starr; Sandra E Nicholson; Donald Metcalf; Nicos A Nicola
Twenty proteins containing a C-terminal SOCS box form five structural classes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):114-9.
1997: D J Curtis; Douglas J Hilton; B Roberts; L Murray; Nicos A Nicola; C Glenn Begley
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.
Blood 1997;90(11):4403-12.
1997: Robyn Starr; Ulrike Novak; T A Willson; Melissa Inglese; V Murphy; W S Alexander; D Metcalf; Nicos A Nicola; Douglas J Hilton; Matthias Ernst
Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction.
The Journal of biological chemistry 1997;272(32):19982-6.
1997: Robyn Starr; Tracy A Willson; Elizabeth M Viney; L J Murray; J R Rayner; Brendan J Jenkins; Thomas J Gonda; Warren S Alexander; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
A family of cytokine-inducible inhibitors of signalling.
Nature 1997;387(6636):917-21.
1997: Harshal H Nandurkar; Lorraine Robb; J K Nicholl; Douglas J Hilton; G R Sutherland; C Glenn Begley
The gene for the human interleukin-11 receptor alpha chain locus is highly homologous to the murine gene and contains alternatively spliced first exons.
The international journal of biochemistry & cell biology 1997;29(5):753-66.
1997: Jian-Guo Zhang; Douglas J Hilton; Tracy A Willson; C McFarlane; B A Roberts; Robert L Moritz; Richard J Simpson; Warren S Alexander; Donald Metcalf; Nicos A Nicola
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.
The Journal of biological chemistry 1997;272(14):9474-80.
1997: Lorraine Robb; Douglas J Hilton; P T Brook-Carter; C Glenn Begley
Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression.
Genomics 1997;40(3):387-94.
1996: T Gainsford; Tracy A Willson; Donald Metcalf; E Handman; C McFarlane; Ashley Ng; Nicos A Nicola; Warren S Alexander; Douglas J Hilton
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14564-8.
1996: S E Nicholson; Robyn Starr; Ulrike Novak; Douglas J Hilton; Judith E Layton
Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells.
The Journal of biological chemistry 1996;271(43):26947-53.
1996: Lorraine Robb; Douglas J Hilton; Tracy A Willson; C Glenn Begley
Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus.
The Journal of biological chemistry 1996;271(23):13754-61.
1996: Evange Romas; Nobuyuki Udagawa; H Zhou; T Tamura; M Saito; T Taga; Douglas J Hilton; T Suda; K W Ng; T John Martin
The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.
The Journal of experimental medicine 1996;183(6):2581-91.
1996: Harshal H Nandurkar; Douglas J Hilton; P Nathan; Tracy A Willson; Nicos A Nicola; C Glenn Begley
The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.
Oncogene 1996;12(3):585-93.
1996: Douglas J Hilton; Jian-Guo Zhang; Donald Metcalf; Warren S Alexander; Nicos A Nicola; Tracy A Willson
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):497-501.
1996: Nicos A Nicola; Elizabeth M Viney; Douglas J Hilton; B Roberts; Tracy A Willson
Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2.
Growth factors (Chur, Switzerland) 1996;13(1-2):141-9.
1995: Donald Metcalf; Tracy A Willson; Douglas J Hilton; Ladina Di Rago; Sandra Mifsud
Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays.
Leukemia 1995;9(9):1556-64.
1995: A A Hilton; AJ Slavin; Douglas J Hilton; Claude C A Bernard
Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein.
Journal of neurochemistry 1995;65(1):309-18.
1994: Douglas J Hilton; A A Hilton; A Raicevic; Steven Rakar; M Harrison-Smith; N M Gough; C Glenn Begley; Donald Metcalf; Nicos A Nicola; Tracy A Willson
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
The EMBO journal 1994;13(20):4765-75.
1994: M J Layton; Catherine M Owczarek; Donald Metcalf; P A Lock; T A Wilson; N M Gough; Douglas J Hilton; Nicos A Nicola
Complex binding of leukemia inhibitory factor to its membrane-expressed and soluble receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):295-8.
1992: Douglas J Hilton; Nicos A Nicola
Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution.
The Journal of biological chemistry 1992;267(15):10238-47.
1992: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and binding properties of receptors for leukaemia inhibitory factor.
Ciba Foundation symposium 1992;167():227-39; discussion 239-44.
1991: Douglas J Hilton; Nicos A Nicola; P M Waring; Donald Metcalf
Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice.
Journal of cellular physiology 1991;148(3):430-9.
1991: Douglas J Hilton; N M Gough
Leukemia inhibitory factor: a biological perspective.
Journal of cellular biochemistry 1991;46(1):21-6.
1991: Mark Murphy; K Reid; Douglas J Hilton; Perry F Bartlett
Generation of sensory neurons is stimulated by leukemia inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3498-501.
1991: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells.
Journal of cellular physiology 1991;146(2):207-15.
1990: E H Allan; Douglas J Hilton; M A Brown; R S Evely; S Yumita; D Metcalf; N M Gough; K W Ng; N A Nicola; T John Martin
Osteoblasts display receptors for and responses to leukemia-inhibitory factor.
Journal of cellular physiology 1990;145(1):110-9.
1990: L R Reid; C Lowe; Jillian Cornish; SJ Skinner; Douglas J Hilton; T A Willson; D P Gearing; T J Martin
Leukemia inhibitory factor: a novel bone-active cytokine.
Endocrinology 1990;126(3):1416-20.
1989: N M Gough; R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; J Stahl; D P Gearing; Nicos A Nicola; Donald Metcalf
LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells.
Reproduction, fertility, and development 1989;1(4):281-8.
1988: R L Williams; Douglas J Hilton; S Pease; Tracy A Willson; C L Stewart; D P Gearing; E F Wagner; Donald Metcalf; Nicos A Nicola; N M Gough
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells.
Nature 1988;336(6200):684-7.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Purification of a murine leukemia inhibitory factor from Krebs ascites cells.
Analytical biochemistry 1988;173(2):359-67.
1988: Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5971-5.
1988: Douglas J Hilton; Nicos A Nicola; N M Gough; Donald Metcalf
Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines.
The Journal of biological chemistry 1988;263(19):9238-43.
1988: N M Gough; D P Gearing; J A King; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Donald Metcalf
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2623-7.
1988: N M Gough; Douglas J Hilton; D P Gearing; Tracy A Willson; J A King; Nicos A Nicola; Donald Metcalf
Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells.
Blood cells 1988;14(2-3):431-42.
1988: Nicos A Nicola; L Peterson; Douglas J Hilton; Donald Metcalf
Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines.
Growth factors (Chur, Switzerland) 1988;1(1):41-9.
1987: D P Gearing; N M Gough; J A King; Douglas J Hilton; Nicos A Nicola; Richard J Simpson; Edouard Nice; A Kelso; Donald Metcalf
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
The EMBO journal 1987;6(13):3995-4002.