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Donald Hilvert

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TOP 3
Hajo Kries; Rebecca Blomberg; Donald Hilvert
De novo enzymes by computational design.
Manuel M Müller; Wilfred F van Gunsteren; Jane R Allison; Laurent Gaillon; Narupat Hongdilokkul; Peter Kast; Philippe Marlière; Donald Hilvert
Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.
Pierre Stallforth; Alexander Adibekian; Dennis G Gillingham; Donald Hilvert; Stefan Matthies; Peter H Seeberger
De novo chemoenzymatic synthesis of sialic acid.

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All Publications

2013: Hajo Kries; Rebecca Blomberg; Donald Hilvert
De novo enzymes by computational design.
Current opinion in chemical biology 2013;17(2):221-8.
2013: Manuel M Müller; Wilfred F van Gunsteren; Jane R Allison; Laurent Gaillon; Narupat Hongdilokkul; Peter Kast; Philippe Marlière; Donald Hilvert
Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.
PLoS genetics 2013;9(1):e1003187.
2012: Pierre Stallforth; Alexander Adibekian; Dennis G Gillingham; Donald Hilvert; Stefan Matthies; Peter H Seeberger
De novo chemoenzymatic synthesis of sialic acid.
Chemical communications (Cambridge, England) 2012;48(98):11987-9.
2012: Florian Richter; Jayaraman Seetharaman; Adam J T Smith; Min Su; Liang Tong; Sergey Vorobiev; Rong Xiao; Rebecca Blomberg; Farhad Forouhar; Jasmine Gallaher; Alexej Grjasnow; Roger C Helgeson; Donald Hilvert; K N Houk; John F Hunt; Sagar D Khare; Gert Kiss; Gregory J Kornhaber; Alexandre P Kuzin; Scott Lew; Gaetano T Montelione; Zbigniew Pianowski; David Baker
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.
Journal of the American Chemical Society 2012;134(39):16197-206.
2012: Norman Metanis; Donald Hilvert
Strategic use of non-native diselenide bridges to steer oxidative protein folding.
Angewandte Chemie (International ed. in English) 2012;51(23):5585-8.
2012: Eric A Althoff; Lars Giger; Sanjay Hari; Daniel Herschlag; Donald Hilvert; Lin Jiang; Peter Kast; Jonathan K Lassila; Matthew Smith; Ling Wang; Zhizhi Wang; David Baker
Robust design and optimization of retroaldol enzymes.
Protein science : a publication of the Protein Society 2012;21(5):717-26.
2012: Heidi K Privett; Leonard M Thomas; Rebecca Blomberg; Roberto A Chica; Donald Hilvert; Kendall N Houk; Gert Kiss; Toni M Lee; Stephen L Mayo
Iterative approach to computational enzyme design.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(10):3790-5.
2012: Ling Wang; Eric A Althoff; Jill Bolduc; Lars Giger; Donald Hilvert; Lin Jiang; Jonathan K Lassila; James Moody; Barry Stoddard; David Baker
Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design.
Journal of molecular biology 2012;415(3):615-25.
2012: Bigna Wörsdörfer; Zbigniew Pianowski; Donald Hilvert
Efficient in vitro encapsulation of protein cargo by an engineered protein container.
Journal of the American Chemical Society 2012;134(2):909-11.
2011: Clemens Mayer; Thomas R Ward; Dennis G Gillingham; Donald Hilvert
An artificial metalloenzyme for olefin metathesis.
Chemical communications (Cambridge, England) 2011;47(44):12068-70.
2011: Hajo Kries; Donald Hilvert
Tailor-made peptide synthetases.
Chemistry & biology 2011;18(10):1206-7.
2011: Maren Butz; Peter Kast; Martin Neuenschwander; Donald Hilvert
An N-terminal protein degradation tag enables robust selection of highly active enzymes.
Biochemistry 2011;50(40):8594-602.
2011: Thorsten Stafforst; Donald Hilvert
Photolyase-like repair of psoralen-crosslinked nucleic acids.
Angewandte Chemie (International ed. in English) 2011;50(40):9483-6.
2011: Bigna Wörsdörfer; Kenneth J Woycechowsky; Donald Hilvert
Directed evolution of a protein container.
Science (New York, N.Y.) 2011;331(6017):589-92.
2010: Thorsten Stafforst; Donald Hilvert
Modulating PNA/DNA hybridization by light.
Angewandte Chemie (International ed. in English) 2010;49(51):9998-10001.
2010: Joris Beld; Kenneth J Woycechowsky; Donald Hilvert
Diselenides as universal oxidative folding catalysts of diverse proteins.
Journal of biotechnology 2010;150(4):481-9.
2010: Christian Jäckel; Donald Hilvert
Biocatalysts by evolution.
Current opinion in biotechnology 2010;21(6):753-9.
2010: Justin B Siegel; Alexandre Zanghellini; Helena M Lovick; Gert Kiss; Abigail R Lambert; Jennifer L St Clair; Jasmine L Gallaher; Donald Hilvert; Michael H Gelb; Barry L Stoddard; Kendall N Houk; Forrest E Michael; David Baker
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction.
Science (New York, N.Y.) 2010;329(5989):309-13.
2010: Christian Jäckel; Jesse D Bloom; Peter Kast; Frances H Arnold; Donald Hilvert
Consensus protein design without phylogenetic bias.
Journal of molecular biology 2010;399(4):541-6.
2010: Manuel M Müller; Hajo Kries; Eva Csuhai; Peter Kast; Donald Hilvert
Design, selection, and characterization of a split chorismate mutase.
Protein science : a publication of the Protein Society 2010;19(5):1000-10.
2010: Jeremy Van Vleet; Andreas Kleeb; Peter Kast; Donald Hilvert; W W Cleland
13C isotope effect on the reaction catalyzed by prephenate dehydratase.
Biochimica et biophysica acta 2010;1804(4):752-4.
2010: Joris Beld; Kenneth J Woycechowsky; Donald Hilvert
Small-molecule diselenides catalyze oxidative protein folding in vivo.
ACS chemical biology 2010;5(2):177-82.
2010: Dennis G Gillingham; Pierre Stallforth; Alexander Adibekian; Peter H Seeberger; Donald Hilvert
Chemoenzymatic synthesis of differentially protected 3-deoxysugars.
Nature chemistry 2010;2(2):102-5.
2009: Erik W Debler; Roger Müller; Donald Hilvert; Ian A Wilson
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18539-44.
2009: Caroline Aldag; Igor A Gromov; Inés García-Rubio; Konstanze von Koenig; Ilme Schlichting; Bernhard Jaun; Donald Hilvert
Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5481-6.
2009: Thorsten Stafforst; Donald Hilvert
Kinetic characterization of spiropyrans in aqueous media.
Chemical communications (Cambridge, England) 2009;(3):287-8.
2009: Manuel M Müller; Matthew A Windsor; William C Pomerantz; Samuel H Gellman; Donald Hilvert
A rationally designed aldolase foldamer.
Angewandte Chemie (International ed. in English) 2009;48(5):922-5.
2008: Adam J T Smith; Roger Müller; Miguel D Toscano; Peter Kast; Homme W Hellinga; Donald Hilvert; K N Houk
Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.
Journal of the American Chemical Society 2008;130(46):15361-73.
2008: Kateryna Fesko; Lars Giger; Donald Hilvert
Synthesis of beta-hydroxy-alpha-amino acids with a reengineered alanine racemase.
Bioorganic & medicinal chemistry letters 2008;18(22):5987-90.
2008: Katherina Vamvaca; Ilian Jelesarov; Donald Hilvert
Kinetics and thermodynamics of ligand binding to a molten globular enzyme and its native counterpart.
Journal of molecular biology 2008;382(4):971-7.
2008: Maite Roca; Benjamin Messer; Donald Hilvert; Arieh Warshel
On the relationship between folding and chemical landscapes in enzyme catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13877-82.
2008: Petra Verdino; Caroline Aldag; Donald Hilvert; Ian A Wilson
Closely related antibody receptors exploit fundamentally different strategies for steroid recognition.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11725-30.
2008: Joris Beld; Kenneth J Woycechowsky; Donald Hilvert
Catalysis of oxidative protein folding by small-molecule diselenides.
Biochemistry 2008;47(27):6985-7.
2008: Giulio Casi; Gerard Roelfes; Donald Hilvert
Selenoglutaredoxin as a glutathione peroxidase mimic.
Chembiochem : a European journal of chemical biology 2008;9(10):1623-31.
2008: Jörg M Serafimov; Dennis Gillingham; Simon Kuster; Donald Hilvert
The putative Diels-Alderase macrophomate synthase is an efficient aldolase.
Journal of the American Chemical Society 2008;130(25):7798-9.
2008: Erik W Debler; Roger Müller; Donald Hilvert; Ian A Wilson
Conformational isomerism can limit antibody catalysis.
The Journal of biological chemistry 2008;283(24):16554-60.
2008: Andrea Piatesi; Caroline Aldag; Donald Hilvert
Switching antibody specificity through minimal mutation.
Journal of molecular biology 2008;377(4):993-1001.
2008: Lin Jiang; Eric A Althoff; Fernando R Clemente; Lindsey Doyle; Daniela Röthlisberger; Alexandre Zanghellini; Jasmine L Gallaher; Jamie L Betker; Fujie Tanaka; Carlos F Barbas; Donald Hilvert; Kendall N Houk; Barry L Stoddard; David Baker
De novo computational design of retro-aldol enzymes.
Science (New York, N.Y.) 2008;319(5868):1387-91.
2008: Christian Jäckel; Peter Kast; Donald Hilvert
Protein design by directed evolution.
Annual review of biophysics 2008;37():153-73.
2007: Konstantin Pervushin; Katherina Vamvaca; Beat Vögeli; Donald Hilvert
Structure and dynamics of a molten globular enzyme.
Nature structural & molecular biology 2007;14(12):1202-6.
2007: Giulio Casi; Donald Hilvert
Reinvestigation of a selenopeptide with purportedly high glutathione peroxidase activity.
The Journal of biological chemistry 2007;282(42):30518-22.
2007: Martin Neuenschwander; Maren Butz; Caroline Heintz; Peter Kast; Donald Hilvert
A simple selection strategy for evolving highly efficient enzymes.
Nature biotechnology 2007;25(10):1145-7.
2007: Andreas C Kleeb; Maryam Hansson Edalat; Marianne Gamper; Johannes Haugstetter; Lars Giger; Martin Neuenschwander; Peter Kast; Donald Hilvert
Metabolic engineering of a genetic selection system with tunable stringency.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13907-12.
2007: Jörg M Serafimov; Thomas Westfeld; Beat H Meier; Donald Hilvert
Trapping and structural elucidation of an intermediate in the macrophomate synthase reaction pathway.
Journal of the American Chemical Society 2007;129(31):9580-1.
2007: Joris Beld; Kenneth J Woycechowsky; Donald Hilvert
Selenoglutathione: efficient oxidative protein folding by a diselenide.
Biochemistry 2007;46(18):5382-90.
2007: Jörg M Serafimov; Hans Christian Lehmann; Hideaki Oikawa; Donald Hilvert
Active site mutagenesis of the putative Diels-Alderase macrophomate synthase.
Chemical communications (Cambridge, England) 2007;(17):1701-3.
2007: Werner Besenmatter; Peter Kast; Donald Hilvert
Relative tolerance of mesostable and thermostable protein homologs to extensive mutation.
Proteins 2007;66(2):500-6.
2007: Roger Müller; Erik W Debler; Michael Steinmann; Florian P Seebeck; Ian A Wilson; Donald Hilvert
Bifunctional catalysis of proton transfer at an antibody active site.
Journal of the American Chemical Society 2007;129(3):460-1.
2007: Miguel D Toscano; Manuel M Müller; Donald Hilvert
Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase.
Angewandte Chemie (International ed. in English) 2007;46(24):4468-70.
2007: Miguel D Toscano; Kenneth J Woycechowsky; Donald Hilvert
Minimalist active-site redesign: teaching old enzymes new tricks.
Angewandte Chemie (International ed. in English) 2007;46(18):3212-36.
2007: Andreas Aemissegger; Donald Hilvert
Synthesis and application of an azobenzene amino acid as a light-switchable turn element in polypeptides.
Nature protocols 2007;2(1):161-7.
2007: Kenneth J Woycechowsky; Katherina Vamvaca; Donald Hilvert
Novel enzymes through design and evolution.
Advances in enzymology and related areas of molecular biology 2007;75():241-94, xiii.
2006: Andreas C Kleeb; Peter Kast; Donald Hilvert
A monofunctional and thermostable prephenate dehydratase from the archaeon Methanocaldococcus jannaschii.
Biochemistry 2006;45(47):14101-10.
2006: Florian P Seebeck; Angelo Guainazzi; Celine Amoreira; Kim K Baldridge; Donald Hilvert
Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase.
Angewandte Chemie (International ed. in English) 2006;45(41):6824-6.
2006: Simon Jurt; Andreas Aemissegger; Peter Güntert; Oliver Zerbe; Donald Hilvert
A photoswitchable miniprotein based on the sequence of avian pancreatic polypeptide.
Angewandte Chemie (International ed. in English) 2006;45(38):6297-300.
2006: Kazuya Kikuchi; Renate B Hannak; Mao-Jun Guo; Anthony J Kirby; Donald Hilvert
Toward bifunctional antibody catalysis.
Bioorganic & medicinal chemistry 2006;14(18):6189-96.
2006: Kenneth J Woycechowsky; Florian P Seebeck; Donald Hilvert
Tunnel plasticity and quaternary structural integrity of a pentameric protein ring.
Protein science : a publication of the Protein Society 2006;15(5):1106-14.
2006: Florian P Seebeck; Kenneth J Woycechowsky; Wei Zhuang; Jürgen P. Rabe; Donald Hilvert
A simple tagging system for protein encapsulation.
Journal of the American Chemical Society 2006;128(14):4516-7.
2006: Michael S DeClue; Kim K Baldridge; Peter Kast; Donald Hilvert
Experimental and computational investigation of the uncatalyzed rearrangement and elimination reactions of isochorismate.
Journal of the American Chemical Society 2006;128(6):2043-51.
2005: Kai U Walter; Katherina Vamvaca; Donald Hilvert
An active enzyme constructed from a 9-amino acid alphabet.
The Journal of biological chemistry 2005;280(45):37742-6.
2005: Michael S DeClue; Kim K Baldridge; Dominik E Künzler; Peter Kast; Donald Hilvert
Isochorismate pyruvate lyase: a pericyclic reaction mechanism?
Journal of the American Chemical Society 2005;127(43):15002-3.
2005: Dominik E Künzler; Severin Sasso; Marianne Gamper; Donald Hilvert; Peter Kast
Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection.
The Journal of biological chemistry 2005;280(38):32827-34.
2005: S Kirk Wright; Michael S DeClue; Ajay Mandal; Lac Lee; Olaf Wiest; W Wallace Cleland; Donald Hilvert
Isotope effects on the enzymatic and nonenzymatic reactions of chorismate.
Journal of the American Chemical Society 2005;127(37):12957-64.
2005: Katherina Vamvaca; Maren Butz; Kai U Walter; Sean V Taylor; Donald Hilvert
Simultaneous optimization of enzyme activity and quaternary structure by directed evolution.
Protein science : a publication of the Protein Society 2005;14(8):2103-14.
2005: Alexander Eletsky; Alexander Kienhöfer; Donald Hilvert; Konstantin Pervushin
Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance.
Biochemistry 2005;44(18):6788-99.
2005: Vincent Kräutler; Andreas Aemissegger; Philippe H Hünenberger; Donald Hilvert; Tomas Hansson; Wilfred F van Gunsteren
Use of molecular dynamics in the design and structure determination of a photoinducible beta-hairpin.
Journal of the American Chemical Society 2005;127(13):4935-42.
2005: Erik W Debler; Shuichiro Ito; Florian P Seebeck; Andreas Heine; Donald Hilvert; Ian A Wilson
Structural origins of efficient proton abstraction from carbon by a catalytic antibody.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):4984-9.
2005: Andreas Aemissegger; Vincent Kräutler; Wilfred F van Gunsteren; Donald Hilvert
A photoinducible beta-hairpin.
Journal of the American Chemical Society 2005;127(9):2929-36.
2005: Florian P Seebeck; Donald Hilvert
Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site.
Journal of the American Chemical Society 2005;127(4):1307-12.
2005: Severin Sasso; Chandra Ramakrishnan; Marianne Gamper; Donald Hilvert; Peter Kast
Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis.
The FEBS journal 2005;272(2):375-89.
2004: Katherina Vamvaca; Beat Vögeli; Peter Kast; Konstantin Pervushin; Donald Hilvert
An enzymatic molten globule: efficient coupling of folding and catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12860-4.
2004: Yunfeng Hu; Kendall N Houk; Kazuya Kikuchi; Kinya Hotta; Donald Hilvert
Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles.
Journal of the American Chemical Society 2004;126(26):8197-205.
2004: Kenneth J Woycechowsky; Donald Hilvert
Deciphering enzymes. Genetic selection as a probe of structure and mechanism.
European journal of biochemistry / FEBS 2004;271(9):1630-7.
2004: Andrea Piatesi; Donald Hilvert
Immunological optimization of a generic hydrophobic pocket for high affinity hapten binding and Diels-Alder activity.
Chembiochem : a European journal of chemical biology 2004;5(4):460-6.
2004: Werner Besenmatter; Peter Kast; Donald Hilvert
New enzymes from combinatorial library modules.
Methods in enzymology 2004;388():91-102.
2003: Silke Wendt; Gregor McCombie; Jürg Daniel; Alexander Kienhöfer; Donald Hilvert; Renato Zenobi
Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS.
Journal of the American Society for Mass Spectrometry 2003;14(12):1470-6.
2003: Giulio Casi; Donald Hilvert
Convergent protein synthesis.
Current opinion in structural biology 2003;13(5):589-94.
2003: Florian P Seebeck; Donald Hilvert
Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation.
Journal of the American Chemical Society 2003;125(34):10158-9.
2003: Gerard Roelfes; Donald Hilvert
Incorporation of selenomethionine into proteins through selenohomocysteine-mediated ligation.
Angewandte Chemie (International ed. in English) 2003;42(20):2275-7.
2003: Ajay Mandal; Donald Hilvert
Charge optimization increases the potency and selectivity of a chorismate mutase inhibitor.
Journal of the American Chemical Society 2003;125(19):5598-9.
2003: Alexander Kienhöfer; Peter Kast; Donald Hilvert
Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor.
Journal of the American Chemical Society 2003;125(11):3206-7.
2003: Gregori Ujaque; Dean J Tantillo; Yunfeng Hu; Kendall N Houk; Kinya Hotta; Donald Hilvert
Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole.
Journal of computational chemistry 2003;24(1):98-110.
2002: Richard Quaderer; Donald Hilvert
Selenocysteine-mediated backbone cyclization of unprotected peptides followed by alkylation, oxidative elimination or reduction of the selenol.
Chemical communications (Cambridge, England) 2002;(22):2620-1.
2002: Renate B Hannak; Robert Konrat; Wolfgang Schüler; Bernhard Kräutler; Maria-Teresa M Auditor; Donald Hilvert
An antibody that reconstitutes the "base-on" form of B(12) coenzymes.
Angewandte Chemie (International ed. in English) 2002;41(19):3613-6, 3515.
2002: Andreas Aemissegger; Bernhard Jaun; Donald Hilvert
Investigation of the enzymatic and nonenzymatic cope rearrangement of carbaprephenate to carbachorismate.
The Journal of organic chemistry 2002;67(19):6725-30.
2002: Alexander Eletsky; Tim Heinz; Osvaldo Moreira; Alexander Kienhöfer; Donald Hilvert; Konstantin Pervushi
Direct NMR observation and DFT calculations of a hydrogen bond at the active site of a 44 kDa enzyme.
Journal of biomolecular NMR 2002;24(1):31-9.
2002: Kinya Hotta; Ian A Wilson; Donald Hilvert
Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism.
Biochemistry 2002;41(3):772-9.
2001: Richard Quaderer; Donald Hilvert
Improved synthesis of C-terminal peptide thioesters on "safety-catch" resins using LiBr/THF.
Organic letters 2001;3(20):3181-4.
2001: S V Taylor; Kai U Walter; Peter Kast; Donald Hilvert
Searching sequence space for protein catalysts.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10596-601.
2000: Peter Kast; C Grisostomi; Irene Ann Chen; Sheng Li; Ute Krengel; Y Xue; Donald Hilvert
A strategically positioned cation is crucial for efficient catalysis by chorismate mutase.
The Journal of biological chemistry 2000;275(47):36832-8.
2000: Marianne Gamper; Donald Hilvert; Peter Kast
Probing the role of the C-terminus of Bacillus subtilis chorismate mutase by a novel random protein-termination strategy.
Biochemistry 2000;39(46):14087-94.
2000: Kinya Hotta; H Lange; Dean J Tantillo; Kendall N Houk; Donald Hilvert; Ian A Wilson
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.
Journal of molecular biology 2000;302(5):1213-25.
2000: D Swinnen; Donald Hilvert
Facile, fmoc-compatible solid-phase synthesis of peptide C-terminal thioesters.
Organic letters 2000;2(16):2439-42.
2000: S Voordijk; T Hansson; Donald Hilvert; Wilfred F van Gunsteren
Molecular dynamics simulations highlight mobile regions in proteins: A novel suggestion for converting a murine V(H) domain into a more tractable species.
Journal of molecular biology 2000;300(4):963-73.
2000: Donald Hilvert
Genetic selection as a tool in mechanistic enzymology and protein design.
Ernst Schering Research Foundation workshop 2000;(32):253-68.
2000: Donald Hilvert
Critical analysis of antibody catalysis.
Annual review of biochemistry 2000;69():751-93.
1999: J Xu; Q Deng; J Chen; Kendall N Houk; J Bartek; Donald Hilvert; Ian A Wilson
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.
Science (New York, N.Y.) 1999;286(5448):2345-8.
1999: A Flohr; Andreas Aemissegger; Donald Hilvert
alpha-Functionalized phosphonylphosphinates: synthesis and evaluation as transcarbamoylase inhibitors.
Journal of medicinal chemistry 1999;42(14):2633-40.
1999: P Mattei; Peter Kast; Donald Hilvert
Bacillus subtilis chorismate mutase is partially diffusion-controlled.
European journal of biochemistry / FEBS 1999;261(1):25-32.
1998: G MacBeath; Peter Kast; Donald Hilvert
Probing enzyme quaternary structure by combinatorial mutagenesis and selection.
Protein science : a publication of the Protein Society 1998;7(8):1757-67.
1998: G MacBeath; Peter Kast; Donald Hilvert
A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii.
Biochemistry 1998;37(28):10062-73.
1998: G MacBeath; Peter Kast; Donald Hilvert
Redesigning enzyme topology by directed evolution.
Science (New York, N.Y.) 1998;279(5358):1958-61.
1998: G MacBeath; Peter Kast; Donald Hilvert
Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity.
Protein science : a publication of the Protein Society 1998;7(2):325-35.
1997: Peter Kast; Donald Hilvert
3D structural information as a guide to protein engineering using genetic selection.
Current opinion in structural biology 1997;7(4):470-9.
1996: Y Tang; N Jiang; C Parakh; Donald Hilvert
Selection of linkers for a catalytic single-chain antibody using phage display technology.
The Journal of biological chemistry 1996;271(26):15682-6.
1996: G MacBeath; Donald Hilvert
Hydrolytic antibodies: variations on a theme.
Chemistry & biology 1996;3(6):433-45.
1996: Peter Kast; M Asif-Ullah; N Jiang; Donald Hilvert
Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5043-8.
1996: K Kikuchi; Donald Hilvert
Antibody catalysis via strategic use of haptenic charge.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1996;50(4):333-6.
1995: E B Peterson; Donald Hilvert
Nonessential active site residues modulate selenosubtilisin's kinetic mechanism.
Biochemistry 1995;34(20):6616-20.
1995: S N Thorn; R G Daniels; M T Auditor; Donald Hilvert
Large rate accelerations in antibody catalysis by strategic use of haptenic charge.
Nature 1995;373(6511):228-30.
1994: K N Morris; T M Tarasow; C M Julin; S L Simons; Donald Hilvert; L Gold
Enrichment for RNA molecules that bind a Diels-Alder transition state analog.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):13028-32.
1994: Donald Hilvert
Chemical synthesis of proteins.
Chemistry & biology 1994;1(4):201-3.
1994: M R Haynes; Enrico STURA; Donald Hilvert; Ian A Wilson
Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart.
Science (New York, N.Y.) 1994;263(5147):646-52.
1994: M R Haynes; Enrico STURA; Donald Hilvert; Ian A Wilson
Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog.
Proteins 1994;18(2):198-200.
1993: I M Bell; Donald Hilvert
Peroxide dependence of the semisynthetic enzyme selenosubtilisin.
Biochemistry 1993;32(50):13969-73.
1993: A P Campbell; T M Tarasow; W Massefski; Peter Wright; Donald Hilvert
Binding of a high-energy substrate conformer in antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8663-7.
1993: R Syed; Z P Wu; James M Hogle; Donald Hilvert
Crystal structure of selenosubtilisin at 2.0-A resolution.
Biochemistry 1993;32(24):6157-64.
1993: I M Bell; M L Fisher; Z P Wu; Donald Hilvert
Kinetic studies on the peroxidase activity of selenosubtilisin.
Biochemistry 1993;32(14):3754-62.
1991: Y Tang; J B Hicks; Donald Hilvert
In vivo catalysis of a metabolically essential reaction by an antibody.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8784-6.
1991: C Lewis; T Krämer; S Robinson; Donald Hilvert
Medium effects in antibody-catalyzed reactions.
Science (New York, N.Y.) 1991;253(5023):1019-22.
1991: K Bowdish; Y Tang; J B Hicks; Donald Hilvert
Yeast expression of a catalytic antibody with chorismate mutase activity.
The Journal of biological chemistry 1991;266(18):11901-8.
1991: Donald Hilvert
Antibody catalysis of carbon-carbon bond formation.
Ciba Foundation symposium 1991;159():174-83; discussion 183-7.
1991: Donald Hilvert
Extending the chemistry of enzymes and abzymes.
Trends in biotechnology 1991;9(1):11-7.
1988: Donald Hilvert; S H Carpenter; K D Nared; M T Auditor
Catalysis of concerted reactions by antibodies: the Claisen rearrangement.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):4953-5.
1987: Donald Hilvert; E T Kaiser
Semisynthetic enzymes: design of flavin-dependent oxidoreductases.
Biotechnology & genetic engineering reviews 1987;5():297-318.