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Alan Hinnebusch

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Saccharomyces cerevisiae

Chemicals & Drugs

Physiology

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Genes & Molecular Sequences

Anatomy

Ribosomes

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Co-Publications
Name
20
Qiu, Hongfang
16
Phan, Lon
15
Valásek, Leos
14
Asano, Katsura
13
Dever, Thomas
13
Zhang, Fan
12
Jackson, BM
11
Nielsen, Klaus
10
Dong, Jinsheng
9
Swanson, Mark
8
Hu, Cuihua
7
Hannig, Ernest
7
Garcia-Barrio, Minerva
7
Anderson, J
7
Pavitt, Graham

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Publications

TOP 3
Nanda Jagpreet S; Cheung Yuen-Nei; Takacs Julie E; Martin-Marcos Pilar; Saini Adesh K; Hinnebusch Alan G; Lorsch Jon R
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.
Dev Kamal; Santangelo Thomas J; Rothenburg Stefan; Neculai Dante; Dey Madhusudan; Sicheri Frank; Dever Thomas E; Reeve John N; Hinnebusch Alan G
Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.
Hinnebusch Alan G
Active destruction of defective ribosomes by a ubiquitin ligase involved in DNA repair.

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All Publications

2009: Nanda Jagpreet S; Cheung Yuen-Nei; Takacs Julie E; Martin-Marcos Pilar; Saini Adesh K; Hinnebusch Alan G; Lorsch Jon R
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.
Journal of molecular biology 2009;394(2):268-85.
2009: Dev Kamal; Santangelo Thomas J; Rothenburg Stefan; Neculai Dante; Dey Madhusudan; Sicheri Frank; Dever Thomas E; Reeve John N; Hinnebusch Alan G
Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.
Journal of molecular biology 2009;392(3):701-22.
2009: Hinnebusch Alan G
Active destruction of defective ribosomes by a ubiquitin ligase involved in DNA repair.
Genes & development 2009;23(8):891-5.
2009: Moxley Joel F; Jewett Michael C; Antoniewicz Maciek R; Villas-Boas Silas G; Alper Hal; Wheeler Robert T; Tong Lily; Hinnebusch Alan G; Ideker Trey; Nielsen Jens; Stephanopoulos Gregory
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6477-82.
2009: Qiu Hongfang; Hu Cuihua; Hinnebusch Alan G
Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters.
Molecular cell 2009;33(6):752-62.
2009: Yoon Sungpil; Hinnebusch Alan G
Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment.
Biochemical and biophysical research communications 2009;381(1):123-8.
2009: Gárriz Andrés; Qiu Hongfang; Dey Madhusudan; Seo Eun-Joo; Dever Thomas E; Hinnebusch Alan G
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
Molecular and cellular biology 2009;29(6):1592-607.
2009: Sonenberg Nahum; Hinnebusch Alan G
Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
Cell 2009;136(4):731-45.
2008: Zhang Fan; Gaur Naseem A; Hasek Jiri; Kim Soon-ja; Qiu Hongfang; Swanson Mark J; Hinnebusch Alan G
Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.
Molecular and cellular biology 2008;28(22):6796-818.
2008: Pascual-García Pau; Govind Chhabi K; Queralt Ethel; Cuenca-Bono Bernardo; Llopis Ana; Chavez Sebastián; Hinnebusch Alan G; Rodríguez-Navarro Susana
Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.
Genes & development 2008;22(20):2811-22.
2008: Szamecz Béla; Rutkai Edit; Cuchalová Lucie; Munzarová Vanda; Herrmannová Anna; Nielsen Klaus H; Burela Laxminarayana; Hinnebusch Alan G; Valásek Leos
eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.
Genes & development 2008;22(17):2414-25.
2008: Dong Jinsheng; Nanda Jagpreet S; Rahman Hafsa; Pruitt Margaret R; Shin Byung-Sik; Wong Chi-Ming; Lorsch Jon R; Hinnebusch Alan G
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection.
Genes & development 2008;22(16):2242-55.
2007: Wong Chi-Ming; Qiu Hongfang; Hu Cuihua; Dong Jinsheng; Hinnebusch Alan G
Yeast cap binding complex impedes recruitment of cleavage factor IA to weak termination sites.
Molecular and cellular biology 2007;27(18):6520-31.
2007: Martín-Marcos Pilar; Hinnebusch Alan G; Tamame Mercedes
Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.
Molecular and cellular biology 2007;27(17):5968-85.
2007: Cheung Yuen-Nei; Maag David; Mitchell Sarah F; Fekete Christie A; Algire Mikkel A; Takacs Julie E; Shirokikh Nikolay; Pestova Tatyana; Lorsch Jon R; Hinnebusch Alan G
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.
Genes & development 2007;21(10):1217-30.
2007: Fekete Christie A; Mitchell Sarah F; Cherkasova Vera A; Applefield Drew; Algire Mikkel A; Maag David; Saini Adesh K; Lorsch Jon R; Hinnebusch Alan G
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection.
The EMBO journal 2007;26(6):1602-14.
2007: Govind Chhabi K; Zhang Fan; Qiu Hongfang; Hofmeyer Kimberly; Hinnebusch Alan G
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.
Molecular cell 2007;25(1):31-42.
2007: Valásek Leos; Szamecz Bela; Hinnebusch Alan G; Nielsen Klaus H
In vivo stabilization of preinitiation complexes by formaldehyde cross-linking.
Methods in enzymology 2007;429():163-83.
2006: Hinnebusch Alan G
eIF3: a versatile scaffold for translation initiation complexes.
Trends in biochemical sciences 2006;31(10):553-62.
2006: Qiu Hongfang; Hu Cuihua; Wong Chi-Ming; Hinnebusch Alan G
The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.
Molecular and cellular biology 2006;26(8):3135-48.
2006: Nielsen Klaus H; Valásek Leos; Sykes Caroah; Jivotovskaya Antonina; Hinnebusch Alan G
Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.
Molecular and cellular biology 2006;26(8):2984-98.
2006: Jivotovskaya Antonina V; Valásek Leos; Hinnebusch Alan G; Nielsen Klaus H
Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast.
Molecular and cellular biology 2006;26(4):1355-72.
2005: Kim Soon-Ja; Swanson Mark J; Qiu Hongfang; Govind Chhabi K; Hinnebusch Alan G
Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo.
Molecular and cellular biology 2005;25(24):11171-83.
2005: Dong Jinsheng; Lai Ruby; Jennings Jennifer L; Link Andrew J; Hinnebusch Alan G
The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis.
Molecular and cellular biology 2005;25(22):9859-73.
2005: Fekete Christie A; Applefield Drew J; Blakely Stephen A; Shirokikh Nikolay; Pestova Tatyana; Lorsch Jon R; Hinnebusch Alan G
The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.
The EMBO journal 2005;24(20):3588-601.
2005: Padyana Anil K; Qiu Hongfang; Roll-Mecak Antonina; Hinnebusch Alan G; Burley Stephen K
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
The Journal of biological chemistry 2005;280(32):29289-99.
2005: Pereira Cátia M; Sattlegger Evelyn; Jiang Hao-Yuan; Longo Beatriz M; Jaqueta Carolina B; Hinnebusch Alan G; Wek Ronald C; Mello Luiz E A M; Castilho Beatriz A
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
The Journal of biological chemistry 2005;280(31):28316-23.
2005: Govind Chhabi K; Yoon Sungpil; Qiu Hongfang; Govind Sudha; Hinnebusch Alan G
Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.
Molecular and cellular biology 2005;25(13):5626-38.
2005: Qiu Hongfang; Hu Cuihua; Zhang Fan; Hwang Gwo Jiunn; Swanson Mark J; Boonchird Cheunchit; Hinnebusch Alan G
Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p.
Molecular and cellular biology 2005;25(9):3461-74.
2005: Dever Thomas E; Hinnebusch Alan G
GCN2 whets the appetite for amino acids.
Molecular cell 2005;18(2):141-2.
2005: Sattlegger Evelyn; Hinnebusch Alan G
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.
The Journal of biological chemistry 2005;280(16):16514-21.
2005: Hinnebusch Alan G
Translational regulation of GCN4 and the general amino acid control of yeast.
Annual review of microbiology 2005;59():407-50.
2005: Magazinnik Tanya; Anand Monika; Sattlegger Evelyn; Hinnebusch Alan G; Kinzy Terri Goss
Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.
Nucleic acids research 2005;33(14):4584-92.
2004: Hinnebusch Alan G; Asano Katsura; Olsen Deanne S; Phan Lon; Nielsen Klaus H; Valásek Leos
Study of translational control of eukaryotic gene expression using yeast.
Annals of the New York Academy of Sciences 2004;1038():60-74.
2004: Valásek Leos; Nielsen Klaus H; Zhang Fan; Fekete Christie A; Hinnebusch Alan G
Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.
Molecular and cellular biology 2004;24(21):9437-55.
2004: Dong Jinsheng; Lai Ruby; Nielsen Klaus; Fekete Christie A; Qiu Hongfang; Hinnebusch Alan G
The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly.
The Journal of biological chemistry 2004;279(40):42157-68.
2004: Yoon Sungpil; Govind Chhabi K; Qiu Hongfang; Kim Soon-ja; Dong Jinsheng; Hinnebusch Alan G
Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11713-8.
2004: Zhang Fan; Sumibcay Laarni; Hinnebusch Alan G; Swanson Mark J
A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p.
Molecular and cellular biology 2004;24(15):6871-86.
2004: Sattlegger Evelyn; Swanson Mark J; Ashcraft Emily A; Jennings Jennifer L; Fekete Richard A; Link Andrew J; Hinnebusch Alan G
YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.
The Journal of biological chemistry 2004;279(29):29952-62.
2004: Qiu Hongfang; Hu Cuihua; Yoon Sungpil; Natarajan Krishnamurthy; Swanson Mark J; Hinnebusch Alan G
An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.
Molecular and cellular biology 2004;24(10):4104-17.
2004: Nielsen Klaus H; Szamecz Béla; Valásek Leos; Jivotovskaya Antonina; Shin Byung-Sik; Hinnebusch Alan G
Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control.
The EMBO journal 2004;23(5):1166-77.
2003: Yoon Sungpil; Qiu Hongfang; Swanson Mark J; Hinnebusch Alan G
Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA.
Molecular and cellular biology 2003;23(23):8829-45.
2003: He Hui; von der Haar Tobias; Singh C Ranjit; Ii Miki; Li Bin; Hinnebusch Alan G; McCarthy John E G; Asano Katsura
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.
Molecular and cellular biology 2003;23(15):5431-45.
2003: Swanson Mark J; Qiu Hongfang; Sumibcay Laarni; Krueger Anna; Kim Soon-ja; Natarajan Krishnamurthy; Yoon Sungpil; Hinnebusch Alan G
A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.
Molecular and cellular biology 2003;23(8):2800-20.
2003: Cherkasova Vera A; Hinnebusch Alan G
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.
Genes & development 2003;17(7):859-72.
2003: Valásek Leos; Mathew Amy A; Shin Byung-Sik; Nielsen Klaus H; Szamecz Béla; Hinnebusch Alan G
The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.
Genes & development 2003;17(6):786-99.
2003: Anand Monika; Chakraburtty Kalpana; Marton Matthew J; Hinnebusch Alan G; Kinzy Terri Goss
Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3.
The Journal of biological chemistry 2003;278(9):6985-91.
2003: Olsen DeAnne S; Savner Erin M; Mathew Amy; Zhang Fan; Krishnamoorthy Thanuja; Phan Lon; Hinnebusch Alan G
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.
The EMBO journal 2003;22(2):193-204.
2002: Valásek Leos; Nielsen Klaus H; Hinnebusch Alan G
Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo.
The EMBO journal 2002;21(21):5886-98.
2002: Garcia-Barrio Minerva; Dong Jinsheng; Cherkasova Vera A; Zhang Xiaolong; Zhang Fan; Ufano Sandra; Lai Ruby; Qin Jun; Hinnebusch Alan G
Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.
The Journal of biological chemistry 2002;277(34):30675-83.
2002: Qiu Hongfang; Hu Cuihua; Dong Jinsheng; Hinnebusch Alan G
Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.
Genes & development 2002;16(10):1271-80.
2002: Algire Mikkel A; Maag David; Savio Peter; Acker Michael G; Tarun Salvador Z; Sachs Alan B; Asano Katsura; Nielsen Klaus H; Olsen Deanne S; Phan Lon; Hinnebusch Alan G; Lorsch Jon R
Development and characterization of a reconstituted yeast translation initiation system.
RNA (New York, N.Y.) 2002;8(3):382-97.
2002: Hinnebusch Alan G; Natarajan Krishnamurthy
Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.
Eukaryotic cell 2002;1(1):22-32.
2002: Asano Katsura; Phan Lon; Krishnamoorthy Thanuja; Pavitt Graham D; Gomez Edith; Hannig Ernest M; Nika Joseph; Donahue Thomas F; Huang Han-kuei; Hinnebusch Alan G
Analysis and reconstitution of translation initiation in vitro.
Methods in enzymology 2002;351():221-47.
2001: Hinnebusch A G
Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12866-8.
2001: Valásek L; Hasek J; Nielsen K H; Hinnebusch A G
Dual function of eIF3j/Hcr1p in processing 20 S pre-rRNA and translation initiation.
The Journal of biological chemistry 2001;276(46):43351-60.
2001: Shalev A; Valásek L; Pise-Masison C A; Radonovich M; Phan L; Clayton J; He H; Brady J N; Hinnebusch A G; Asano K
Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.
The Journal of biological chemistry 2001;276(37):34948-57.
2001: Krishnamoorthy T; Pavitt G D; Zhang F; Dever T E; Hinnebusch A G
Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.
Molecular and cellular biology 2001;21(15):5018-30.
2001: Natarajan K; Meyer M R; Jackson B M; Slade D; Roberts C; Hinnebusch A G; Marton M J
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast.
Molecular and cellular biology 2001;21(13):4347-68.
2001: Zhang F; Romano P R; Nagamura-Inoue T; Tian B; Dever T E; Mathews M B; Ozato K; Hinnebusch A G
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.
The Journal of biological chemistry 2001;276(27):24946-58.
2001: Phan L; Schoenfeld L W; Valásek L; Nielsen K H; Hinnebusch A G
A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.
The EMBO journal 2001;20(11):2954-65.
2001: Asano K; Shalev A; Phan L; Nielsen K; Clayton J; Valásek L; Donahue T F; Hinnebusch A G
Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.
The EMBO journal 2001;20(9):2326-37.
2001: Qiu H; Dong J; Hu C; Francklyn C S; Hinnebusch A G
The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.
The EMBO journal 2001;20(6):1425-38.
2001: Akiyoshi Y; Clayton J; Phan L; Yamamoto M; Hinnebusch A G; Watanabe Y; Asano K
Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
The Journal of biological chemistry 2001;276(13):10056-62.
2001: Valásek L; Phan L; Schoenfeld L W; Valásková V; Hinnebusch A G
Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.
The EMBO journal 2001;20(4):891-904.
2001: Taylor D R; Tian B; Romano P R; Hinnebusch A G; Lai M M; Mathews M B
Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.
Journal of virology 2001;75(3):1265-73.
2001: Asano K; Phan L; Valásek L; Schoenfeld L W; Shalev A; Clayton J; Nielsen K; Donahue T F; Hinnebusch A G
A multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition.
Cold Spring Harbor symposia on quantitative biology 2001;66():403-15.
2001: Asano K; Hinnebusch A G
Protein interactions important in eukaryotic translation initiation.
Methods in molecular biology (Clifton, N.J.) 2001;177():179-98.
2000: Sattlegger E; Hinnebusch A G
Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.
The EMBO journal 2000;19(23):6622-33.
2000: Asano K; Clayton J; Shalev A; Hinnebusch A G
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
Genes & development 2000;14(19):2534-46.
2000: Choi S K; Olsen D S; Roll-Mecak A; Martung A; Remo K L; Burley S K; Hinnebusch A G; Dever T E
Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.
Molecular and cellular biology 2000;20(19):7183-91.
2000: Dong J; Qiu H; Garcia-Barrio M; Anderson J; Hinnebusch A G
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.
Molecular cell 2000;6(2):269-79.
2000: Nika J; Yang W; Pavitt G D; Hinnebusch A G; Hannig E M
Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiae.
The Journal of biological chemistry 2000;275(34):26011-7.
2000: Anderson J; Phan L; Hinnebusch A G
The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5173-8.
2000: Garcia-Barrio M; Dong J; Ufano S; Hinnebusch A G
Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation.
The EMBO journal 2000;19(8):1887-99.
2000: Qiu H; Hu C; Anderson J; Björk G R; Sarkar S; Hopper A K; Hinnebusch A G
Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
Molecular and cellular biology 2000;20(7):2505-16.
1999: Natarajan K; Jackson B M; Zhou H; Winston F; Hinnebusch A G
Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator.
Molecular cell 1999;4(4):657-64.
1999: Calvo O; Cuesta R; Anderson J; Gutiérrez N; García-Barrio M T; Hinnebusch A G; Tamame M
GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(6):4167-81.
1999: Asano K; Krishnamoorthy T; Phan L; Pavitt G D; Hinnebusch A G
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.
The EMBO journal 1999;18(6):1673-88.
1999: Hoffmann B; Mösch H U; Sattlegger E; Barthelmess I B; Hinnebusch A; Braus G H
The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino-acid starvation.
Molecular microbiology 1999;31(3):807-22.
1998: Anderson J; Phan L; Cuesta R; Carlson B A; Pak M; Asano K; Björk G R; Tamame M; Hinnebusch A G
The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.
Genes & development 1998;12(23):3650-62.
1998: Romano P R; Zhang F; Tan S L; Garcia-Barrio M T; Katze M G; Dever T E; Hinnebusch A G
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain.
Molecular and cellular biology 1998;18(12):7304-16.
1998: Natarajan K; Jackson B M; Rhee E; Hinnebusch A G
yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex.
Molecular cell 1998;2(5):683-92.
1998: Greenberg J R; Phan L; Gu Z; deSilva A; Apolito C; Sherman F; Hinnebusch A G; Goldfarb D S
Nip1p associates with 40 S ribosomes and the Prt1p subunit of eukaryotic initiation factor 3 and is required for efficient translation initiation.
The Journal of biological chemistry 1998;273(36):23485-94.
1998: Sattlegger E; Hinnebusch A G; Barthelmess I B
cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control.
The Journal of biological chemistry 1998;273(32):20404-16.
1998: Phan L; Zhang X; Asano K; Anderson J; Vornlocher H P; Greenberg J R; Qin J; Hinnebusch A G
Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5.
Molecular and cellular biology 1998;18(8):4935-46.
1998: Asano K; Phan L; Anderson J; Hinnebusch A G
Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(29):18573-85.
1998: Zhang X; Herring C J; Romano P R; Szczepanowska J; Brzeska H; Hinnebusch A G; Qin J
Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis.
Analytical chemistry 1998;70(10):2050-9.
1998: Kimball S R; Fabian J R; Pavitt G D; Hinnebusch A G; Jefferson L S
Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b.
The Journal of biological chemistry 1998;273(21):12841-5.
1998: Qiu H; Garcia-Barrio M T; Hinnebusch A G
Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.
Molecular and cellular biology 1998;18(5):2697-711.
1998: Romano P R; Garcia-Barrio M T; Zhang X; Wang Q; Taylor D R; Zhang F; Herring C; Mathews M B; Qin J; Hinnebusch A G
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.
Molecular and cellular biology 1998;18(4):2282-97.
1998: Cuesta R; Hinnebusch A G; Tamame M
Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae.
Genetics 1998;148(3):1007-20.
1998: Drysdale C M; Jackson B M; McVeigh R; Klebanow E R; Bai Y; Kokubo T; Swanson M; Nakatani Y; Weil P A; Hinnebusch A G
The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex.
Molecular and cellular biology 1998;18(3):1711-24.
1998: Pavitt G D; Ramaiah K V; Kimball S R; Hinnebusch A G
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
Genes & development 1998;12(4):514-26.
1998: Kokubo T; Swanson M J; Nishikawa J I; Hinnebusch A G; Nakatani Y
The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein.
Molecular and cellular biology 1998;18(2):1003-12.
1997: Hinnebusch A G
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome.
The Journal of biological chemistry 1997;272(35):21661-4.
1997: Marton M J; Vazquez de Aldana C R; Qiu H; Chakraburtty K; Hinnebusch A G
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
Molecular and cellular biology 1997;17(8):4474-89.
1997: Zhang F; Kirouac M; Zhu N; Hinnebusch A G; Rolfes R J
Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription.
Molecular and cellular biology 1997;17(6):3272-83.
1997: Rolfes R J; Zhang F; Hinnebusch A G
The transcriptional activators BAS1, BAS2, and ABF1 bind positive regulatory sites as the critical elements for adenine regulation of ADE5,7.
The Journal of biological chemistry 1997;272(20):13343-54.
1997: Pavitt G D; Yang W; Hinnebusch A G
Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.
Molecular and cellular biology 1997;17(3):1298-313.
1996: Yang W; Hinnebusch A G
Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2.
Molecular and cellular biology 1996;16(11):6603-16.
1996: Taylor D R; Lee S B; Romano P R; Marshak D R; Hinnebusch A G; Esteban M; Mathews M B
Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.
Molecular and cellular biology 1996;16(11):6295-302.
1996: Jackson B M; Drysdale C M; Natarajan K; Hinnebusch A G
Identification of seven hydrophobic clusters in GCN4 making redundant contributions to transcriptional activation.
Molecular and cellular biology 1996;16(10):5557-71.
1995: Dever T E; Yang W; Aström S; Byström A S; Hinnebusch A G
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.
Molecular and cellular biology 1995;15(11):6351-63.
1995: Grant C M; Miller P F; Hinnebusch A G
Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.
Nucleic acids research 1995;23(19):3980-8.
1995: Vazquez de Aldana C R; Marton M J; Hinnebusch A G
GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.
The EMBO journal 1995;14(13):3184-99.
1995: Garcia-Barrio M T; Naranda T; Vazquez de Aldana C R; Cuesta R; Hinnebusch A G; Hershey J W; Tamame M
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.
Genes & development 1995;9(14):1781-96.
1995: Flowers K M; Kimball S R; Feldhoff R C; Hinnebusch A G; Jefferson L S
Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4274-8.
1995: Drysdale C M; Dueñas E; Jackson B M; Reusser U; Braus G H; Hinnebusch A G
The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids.
Molecular and cellular biology 1995;15(3):1220-33.
1995: Romano P R; Green S R; Barber G N; Mathews M B; Hinnebusch A G
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.
Molecular and cellular biology 1995;15(1):365-78.
1994: Vazquez de Aldana C R; Wek R C; Segundo P S; Truesdell A G; Hinnebusch A G
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.
Molecular and cellular biology 1994;14(12):7920-32.
1994: Hinnebusch A G
The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress.
Seminars in cell biology 1994;5(6):417-26.
1994: Hinnebusch A G
Translational control of GCN4: an in vivo barometer of initiation-factor activity.
Trends in biochemical sciences 1994;19(10):409-14.
1994: Vazquez de Aldana C R; Hinnebusch A G
Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.
Molecular and cellular biology 1994;14(5):3208-22.
1994: Grant C M; Miller P F; Hinnebusch A G
Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron.
Molecular and cellular biology 1994;14(4):2616-28.
1994: Grant C M; Hinnebusch A G
Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control.
Molecular and cellular biology 1994;14(1):606-18.
1993: Hinnebusch A G
Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.
Molecular microbiology 1993;10(2):215-23.
1993: Rolfes R J; Hinnebusch A G
Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
Molecular and cellular biology 1993;13(8):5099-111.
1993: Bushman J L; Foiani M; Cigan A M; Paddon C J; Hinnebusch A G
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.
Molecular and cellular biology 1993;13(8):4618-31.
1993: Vazquez de Aldana C R; Dever T E; Hinnebusch A G
Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7215-9.
1993: Cigan A M; Bushman J L; Boal T R; Hinnebusch A G
A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5350-4.
1993: Marton M J; Crouch D; Hinnebusch A G
GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
Molecular and cellular biology 1993;13(6):3541-56.
1993: Barber G N; Wambach M; Wong M L; Dever T E; Hinnebusch A G; Katze M G
Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4621-5.
1993: Dever T E; Chen J J; Barber G N; Cigan A M; Feng L; Donahue T F; London I M; Katze M G; Hinnebusch A G
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4616-20.
1993: Bushman J L; Asuru A I; Matts R L; Hinnebusch A G
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.
Molecular and cellular biology 1993;13(3):1920-32.
1992: Ramirez M; Wek R C; Vazquez de Aldana C R; Jackson B M; Freeman B; Hinnebusch A G
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
Molecular and cellular biology 1992;12(12):5801-15.
1992: Wek R C; Cannon J F; Dever T E; Hinnebusch A G
Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.
Molecular and cellular biology 1992;12(12):5700-10.
1992: Lindahl L; Hinnebusch A
Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes.
Current opinion in genetics & development 1992;2(5):720-6.
1992: Lanker S; Bushman J L; Hinnebusch A G; Trachsel H; Mueller P P
Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms.
Cell 1992;70(4):647-57.
1992: Dancis A; Roman D G; Anderson G J; Hinnebusch A G; Klausner R D
Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3869-73.
1992: Dever T E; Feng L; Wek R C; Cigan A M; Donahue T F; Hinnebusch A G
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.
Cell 1992;68(3):585-96.
1991: Cigan A M; Foiani M; Hannig E M; Hinnebusch A G
Complex formation by positive and negative translational regulators of GCN4.
Molecular and cellular biology 1991;11(6):3217-28.
1991: Foiani M; Cigan A M; Paddon C J; Harashima S; Hinnebusch A G
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.
Molecular and cellular biology 1991;11(6):3203-16.
1991: Ramirez M; Wek R C; Hinnebusch A G
Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae.
Molecular and cellular biology 1991;11(6):3027-36.
1991: Moehle C M; Hinnebusch A G
Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae.
Molecular and cellular biology 1991;11(5):2723-35.
1991: Abastado J P; Miller P F; Hinnebusch A G
A quantitative model for translational control of the GCN4 gene of Saccharomyces cerevisiae.
The New biologist 1991;3(5):511-24.
1991: Abastado J P; Miller P F; Jackson B M; Hinnebusch A G
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.
Molecular and cellular biology 1991;11(1):486-96.
1990: Hannig E M; Williams N P; Wek R C; Hinnebusch A G
The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.
Genetics 1990;126(3):549-62.
1990: Miller P F; Hinnebusch A G
cis-acting sequences involved in the translational control of GCN4 expression.
Biochimica et biophysica acta 1990;1050(1-3):151-4.
1990: Wek R C; Ramirez M; Jackson B M; Hinnebusch A G
Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.
Molecular and cellular biology 1990;10(6):2820-31.
1990: Dancis A; Klausner R D; Hinnebusch A G; Barriocanal J G
Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(5):2294-301.
1990: Hinnebusch A G
Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA.
Trends in biochemical sciences 1990;15(4):148-52.
1989: Williams N P; Hinnebusch A G; Donahue T F
Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7515-9.
1989: Miller P F; Hinnebusch A G
Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control.
Genes & development 1989;3(8):1217-25.
1989: Paddon C J; Hannig E M; Hinnebusch A G
Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition.
Genetics 1989;122(3):551-9.
1989: Paddon C J; Hinnebusch A G
gcd12 mutations are gcn3-dependent alleles of GCD2, a negative regulator of GCN4 in the general amino acid control of Saccharomyces cerevisiae.
Genetics 1989;122(3):543-50.
1989: Wek R C; Jackson B M; Hinnebusch A G
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4579-83.
1988: Mueller P P; Jackson B M; Miller P F; Hinnebusch A G
The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence.
Molecular and cellular biology 1988;8(12):5439-47.
1988: Hannig E M; Hinnebusch A G
Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function.
Molecular and cellular biology 1988;8(11):4808-20.
1988: Hinnebusch A G; Jackson B M; Mueller P P
Evidence for regulation of reinitiation in translational control of GCN4 mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7279-83.
1988: Williams N P; Mueller P P; Hinnebusch A G
The positive regulatory function of the 5'-proximal open reading frames in GCN4 mRNA can be mimicked by heterologous, short coding sequences.
Molecular and cellular biology 1988;8(9):3827-36.
1987: Harashima S; Hannig E M; Hinnebusch A G
Interactions between positive and negative regulators of GCN4 controlling gene expression and entry into the yeast cell cycle.
Genetics 1987;117(3):409-19.
1987: Mueller P P; Harashima S; Hinnebusch A G
A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2863-7.
1986: Mueller P P; Hinnebusch A G
Multiple upstream AUG codons mediate translational control of GCN4.
Cell 1986;45(2):201-7.

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