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Okio Hino

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Living Beings

Genes & Molecular Sequences

Tumor Suppressor Genes

Physiology

Concepts & Ideas

Molecular Sequence Data

Procedures

Polymerase Chain Reaction

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Publications

TOP 3
Piao Xianghua; Kobayashi Toshiyuki; Wang Lu; Shiono Masatoshi; Takagi Yumiko; Sun Guodong; Abe Masaaki; Hagiwara Yoshiaki; Zhang Danqing; Okimoto Kazuo; Kouchi Mami; Matsumoto Izumi; Hino Okio
Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.
Takahashi Fumiyuki; Kumasaka Toshio; Nagaoka Tetsutaro; Wakiya Midori; Fujii Hiroaki; Shimizu Kazue; Uchida Koji; Morio Yoshiteru; Seyama Kuniaki; Hino Okio; Takahashi Kazuhisa; Fukuchi Yoshinosuke
Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma.
Tsuji Atsushi B; Sogawa Chizuru; Sugyo Aya; Sudo Hitomi; Toyohara Jun; Koizumi Mitsuru; Abe Masaaki; Hino Okio; Harada Yoshi-nobu; Furukawa Takako; Suzuki Kazutoshi; Saga Tsuneo
Comparison of conventional and novel PET tracers for imaging mesothelioma in nude mice with subcutaneous and intrapleural xenografts.

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All Publications

2009: Piao Xianghua; Kobayashi Toshiyuki; Wang Lu; Shiono Masatoshi; Takagi Yumiko; Sun Guodong; Abe Masaaki; Hagiwara Yoshiaki; Zhang Danqing; Okimoto Kazuo; Kouchi Mami; Matsumoto Izumi; Hino Okio
Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.
Biochemical and biophysical research communications 2009;389(1):16-21.
2009: Takahashi Fumiyuki; Kumasaka Toshio; Nagaoka Tetsutaro; Wakiya Midori; Fujii Hiroaki; Shimizu Kazue; Uchida Koji; Morio Yoshiteru; Seyama Kuniaki; Hino Okio; Takahashi Kazuhisa; Fukuchi Yoshinosuke
Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma.
Pathology international 2009;59(10):752-6.
2009: Tsuji Atsushi B; Sogawa Chizuru; Sugyo Aya; Sudo Hitomi; Toyohara Jun; Koizumi Mitsuru; Abe Masaaki; Hino Okio; Harada Yoshi-nobu; Furukawa Takako; Suzuki Kazutoshi; Saga Tsuneo
Comparison of conventional and novel PET tracers for imaging mesothelioma in nude mice with subcutaneous and intrapleural xenografts.
Nuclear medicine and biology 2009;36(4):379-88.
2009: Ishikawa Kiyoshi; Segawa Tatsuya; Hagiwara Yoshiaki; Maeda Masahiro; Abe Masaaki; Hino Okio
Establishment of novel mAb to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers.
Pathology international 2009;59(3):161-6.
2008: Inami Koichi; Kajino Kazunori; Abe Masaaki; Hagiwara Yoshiaki; Maeda Masahiro; Suyama Masafumi; Watanabe Sumio; Hino Okio
Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma.
Oncology reports 2008;20(6):1375-80.
2008: Tajima Ken; Hirama Michihiro; Shiomi Kazu; Ishiwata Toshiji; Yoshioka Masataka; Iwase Akihiko; Iwakami Shinichiro; Yamazaki Mariko; Toba Michie; Tobino Kazunori; Sugano Koji; Ichikawa Masako; Hagiwara Yoshiaki; Takahashi Kazuhisa; Hino Okio
ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma.
Anticancer research 2008;28(6B):3933-6.
2008: Shiono M; Kobayashi T; Takahashi R; Sun G; Abe M; Zhang D; Wang L; Piao X; Takagi Y; Mineki R; Taka H; Tada N; Sonobe S; Momose S; Ueda M; Hino O
The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition.
Oncogene 2008;27(52):6690-7.
2008: Takagi Y; Kobayashi T; Shiono M; Wang L; Piao X; Sun G; Zhang D; Abe M; Hagiwara Y; Takahashi K; Hino O
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.
Oncogene 2008;27(40):5339-47.
2008: Imamura Osamu; Okada Hiroaki; Takashima Yuuki; Zhang Danqing; Kobayashi Toshiyuki; Hino Okio
siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model.
Cancer letters 2008;268(2):278-85.
2008: Segawa Tatsuya; Hagiwara Yoshiaki; Ishikawa Kiyoshi; Aoki Naoko; Maeda Masahiro; Shiomi Kazu; Hino Okio
MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus.
Biochemical and biophysical research communications 2008;369(3):915-8.
2008: Shigeyama Yutaka; Kobayashi Toshiyuki; Kido Yoshiaki; Hashimoto Naoko; Asahara Shun-Ichiro; Matsuda Tomokazu; Takeda Akihiko; Inoue Tae; Shibutani Yuki; Koyanagi Maki; Uchida Tohru; Inoue Maki; Hino Okio; Kasuga Masato; Noda Tetsuo
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice.
Molecular and cellular biology 2008;28(9):2971-9.
2008: Hagiwara Yoshiaki; Hamada Yukiko; Kuwahara Maki; Maeda Masahiro; Segawa Tatsuya; Ishikawa Kiyoshi; Hino Okio
Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma.
Cancer science 2008;99(4):666-70.
2008: Hino Okio; Maeda Masahiro
Diagnostic tumor marker of asbestos-related mesothelioma.
Environmental health and preventive medicine 2008;13(2):71-4.
2008: Shiomi Kazu; Hagiwara Yoshiaki; Sonoue Kouji; Segawa Tatsuya; Miyashita Kazuya; Maeda Masahiro; Izumi Hiroshi; Masuda Kimihiko; Hirabayashi Masataka; Moroboshi Takao; Yoshiyama Takashi; Ishida Atsuko; Natori Yuji; Inoue Akira; Kobayashi Masashi; Sakao Yukinori; Miyamoto Hideaki; Takahashi Kazuhisa; Hino Okio
Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1431-7.
2008: Suzuki Tsukasa; Das Swadesh K; Inoue Hirohumi; Kazami Machiko; Hino Okio; Kobayashi Toshiyuki; Yeung Raymond S; Kobayashi Ken-Ichi; Tadokoro Tadahiro; Yamamoto Yuji
Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation.
Biochemical and biophysical research communications 2008;368(1):132-7.
2008: Kouchi Mami; Okimoto Kazuo; Matsumoto Izumi; Michimae Yoshiko; Yamada Toru; Inoue Tadashi; Kimura Toru; Seki Takaki; Yasuba Masashi; Hino Okio
Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2008;59(5):273-9.
2008: Kim Soo Ryang; Kudo Masatoshi; Hino Okio; Han Kwang Hyub; Chung Young Hwa; Lee Hyo Suk;
Epidemiology of hepatocellular carcinoma in Japan and Korea. A review.
Oncology 2008;75 Suppl 1():13-6.
2007: Minami Kahori; Tambe Yukihiro; Watanabe Ryosuke; Isono Takahiro; Haneda Masataka; Isobe Ken-Ichi; Kobayashi Toshiyuki; Hino Okio; Okabe Hidetoshi; Chano Tokuhiro; Inoue Hirokazu
Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.
Journal of virology 2007;81(20):11106-15.
2007: Sun Guo Dong; Kobayashi Toshiyuki; Abe Masaaki; Tada Norihiro; Adachi Hiroyuki; Shiota Akira; Totsuka Yoshikazu; Hino Okio
The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation.
Biochemical and biophysical research communications 2007;360(1):181-7.
2007: Nakaishi Masayuki; Kajino Kazunori; Ikesue Masahiro; Hagiwara Yoshiaki; Kuwahara Maki; Mitani Hiroaki; Horikoshi-Sakuraba Yuko; Segawa Tatsuya; Kon Shigeyuki; Maeda Masahiro; Wang Tegexibaiyin; Abe Masaaki; Yokoyama Masayoshi; Hino Okio
Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin.
Cancer science 2007;98(5):659-64.
2007: Momose Shuji; Kobayashi Toshiyuki; Tada Norihiro; Itoyama Shinji; Hino Okio
N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo.
Biochemical and biophysical research communications 2007;356(3):693-8.
2007: Hino Okio; Wakabayashi Keiji; Tatematsu Masae; Tajima Kazuo
'On environmental carcinogens: from an era of risk evaluation to an era of risk management' Tokyo, Japan, 29 july 2006.
Cancer science 2007;98(4):617-9.
2007: Jiang Wenquan; Fujii Hiroaki; Matsumoto Toshiharu; Ohtsuji Naomi; Tsurumaru Masahiko; Hino Okio
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability.
Cancer letters 2007;248(1):103-11.
2007: Watanabe Ryosuke; Tambe Yukihiro; Inoue Hirokazu; Isono Takahiro; Haneda Masataka; Isobe Ken-Ichi; Kobayashi Toshiyuki; Hino Okio; Okabe Hidetoshi; Chano Tokuhiro
GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress.
International journal of molecular medicine 2007;19(3):475-83.
2007: Hino Okio
Revisit: Yamagiwa's Carcinogenesis.
Oncology 2007;72 Suppl 1():1.
2006: Cao Yongheng; Kamioka Yuji; Yokoi Norihide; Kobayashi Toshiyuki; Hino Okio; Onodera Masafumi; Mochizuki Naoki; Nakae Jun
Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
The Journal of biological chemistry 2006;281(52):40242-51.
2006: Matsumoto Fumihiko; Fujii Hiroaki; Abe Masaaki; Kajino Kazunori; Kobayashi Toshiyuki; Matsumoto Toshiharu; Ikeda Katsuhisa; Hino Okio
A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.
Human pathology 2006;37(12):1592-600.
2006: Maeda Masahiro; Hino Okio
Molecular tumor markers for asbestos-related mesothelioma: serum diagnostic markers.
Pathology international 2006;56(11):649-54.
2006: Tobita Hiroshi; Kajino Kazunori; Inami Kouichi; Kano Sayaka; Yasen Mahmut; Imamura Osamu; Kinoshita Yoshikazu; Hino Okio
Gene expression profile of DNA binding protein A transgenic mice.
International journal of oncology 2006;29(3):673-9.
2006: Chano Tokuhiro; Saji Masashi; Inoue Hirokazu; Minami Kahori; Kobayashi Toshiyuki; Hino Okio; Okabe Hidetoshi
Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation.
International journal of molecular medicine 2006;18(3):425-32.
2006: Shiomi Kazu; Miyamoto Hideaki; Segawa Tatsuya; Hagiwara Yoshiaki; Ota Akinobu; Maeda Masahiro; Takahashi Kazuhisa; Masuda Kimihiko; Sakao Yukinori; Hino Okio
Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients.
Cancer science 2006;97(9):928-32.
2006: Fujii H; Jiang W; Matsumoto T; Miyai K; Sashara K; Ohtsuji N; Hino O
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability.
The Journal of pathology 2006;209(3):328-35.
2006: Togashi Y; Kobayashi T; Momose S; Ueda M; Okimoto K; Hino O
Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
Oncogene 2006;25(20):2885-9.
2006: Kouchi Mami; Okimoto Kazuo; Matsumoto Izumi; Tanaka Kohji; Yasuba Masashi; Hino Okio
Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome.
Virchows Archiv : an international journal of pathology 2006;448(4):463-71.
2006: Watanabe Terubumi; Goto Keigo; Takanashi Masashi; Mori Hideo; Fujii Hiroaki; Hino Okio; Mochizuki Hideki; Mizuno Yoshikuni
[An 80-year-old woman with progressive stroke, who had rheumatoid arthritis and antiphospholipid syndrome]
No to shinkei = Brain and nerve 2006;58(2):173-81.
2006: Yamamoto Hidetaka; Oda Yoshinao; Yao Takashi; Oiwa Toshio; Kobayashi Chikashi; Tamiya Sadafumi; Kawaguchi Ken-ichi; Hino Okio; Tsuneyoshi Masazumi
Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysis.
Pathology international 2006;56(1):46-50.
2006: Orita H; Sakamoto N; Ajioka Y; Terai T; Hino O; Sato N; Shimoda T; Kamano T; Tsurumaru M; Fujii H
Allelic loss analysis of early-stage flat-type colorectal tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):43-9.
2006: Maeda Masahiro; Hino Okio
Blood tests for asbestos-related mesothelioma.
Oncology 2006;71(1-2):26-31.
2006: Hino Okio; Kobayashi Toshiyuki; Okimoto Kazuo
Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview.
EXS 2006;(96):269-92.
2005: Yasen Mahmut; Kajino Kazunori; Kano Sayaka; Tobita Hiroshi; Yamamoto Junji; Uchiumi Takeshi; Kon Shigeyuki; Maeda Masahiro; Obulhasim Gulanbar; Arii Shigeki; Hino Okio
The up-regulation of Y-box binding proteins (DNA binding protein A and Y-box binding protein-1) as prognostic markers of hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7354-61.
2005: Ma Li; Teruya-Feldstein Julie; Behrendt Nille; Chen Zhenbang; Noda Tetsuo; Hino Okio; Cordon-Cardo Carlos; Pandolfi Pier Paolo
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.
Genes & development 2005;19(15):1779-86.
2005: Fujii Hiroaki; Gabrielson Edward; Takagaki Tetsuya; Ohtsuji Mareki; Ohtsuji Naomi; Hino Okio
Frequent down-regulation of HIVEP2 in human breast cancer.
Breast cancer research and treatment 2005;91(2):103-12.
2005: Hino Okio
[Federal headship of carcinogenesis--genotype, phenotype, and dramatype]
Fukuoka igaku zasshi = Hukuoka acta medica 2005;96(1):1-4.
2005: Hino Okio
Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis.
Intervirology 2005;48(1):6-9.
2005: Ishii Takamasa; Yasuda Kayo; Akatsuka Akira; Hino Okio; Hartman Philip S; Ishii Naoaki
A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.
Cancer research 2005;65(1):203-9.
2004: Okimoto Kazuo; Kouchi Mami; Matsumoto Izumi; Sakurai Junko; Kobayashi Toshiyuki; Hino Okio
Natural history of the Nihon rat model of BHD.
Current molecular medicine 2004;4(8):887-93.
2004: Hino Okio
Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.
Current molecular medicine 2004;4(8):807-11.
2004: Nakadai Taeko; Nojima Kumie; Kobayashi Ikuo; Sato Kayoko; Yasuda Nakahiro; Mitani Hiroaki; Hino Okio
HZE radiation effects for hereditary renal carcinomas.
Uchu Seibutsu Kagaku 2004;18(3):177-8.
2004: Sakamoto Naoto; Terai Takeshi; Ajioka Yoichi; Abe Satoshi; Kobayasi Osamu; Hirai Shu; Hino Okio; Watanabe Hidenobu; Sato Nobuhiro; Shimoda Tadakazu; Fujii Hiroaki
Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
Oncogene 2004;23(55):8900-7.
2004: Kanenishi Kenji; Ueno Masaki; Momose Shuji; Kuwabara Hiroko; Tanaka Hirokazu; Sato Chubun; Kobayashi Toshiyuki; Hino Okio; Sakamoto Haruhiko; Hata Toshiyuki
Prepro-orexin mRNA expression in the rat brain is increased during pregnancy.
Neuroscience letters 2004;368(1):73-7.
2004: Arakawa Yasuo; Kajino Kazunori; Kano Sayaka; Tobita Hiroshi; Hayashi Junpei; Yasen Mahamute; Moriyama Mitsuhiko; Arakawa Yasuyuki; Hino Okio
Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis.
Biochemical and biophysical research communications 2004;322(1):297-302.
2004: Tobita Hiroshi; Hino Okio
[Molecular mechanism of HBV-related hepatocarcinogenesis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():367-71.
2004: Hino Okio
[Philosophy of cancer--guiding principle of transition and formative force of new era]
Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 2004;101(8):855-9.
2004: Hino Okio
Studies of familial tumors using models: genotype, phenotype, and dramatype in carcinogenesis.
International journal of clinical oncology / Japan Society of Clinical Oncology 2004;9(4):257-61.
2004: Sato T; Seyama K; Kumasaka T; Fujii H; Setoguchi Y; Shirai T; Tomino Y; Hino O; Fukuchi Y
A patient with TSC1 germline mutation whose clinical phenotype was limited to lymphangioleiomyomatosis.
Journal of internal medicine 2004;256(2):166-73.
2004: Okamoto Toshihiro; Kobayashi Toshiyuki; Hino Okio
Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liver.
International journal of molecular medicine 2004;13(4):573-6.
2004: Adachi Hiroyuki; Majima Shuichi; Kon Shigeyuki; Kobayashi Toshiyuki; Kajino Kazunori; Mitani Hiroaki; Hirayama Youko; Shiina Hiroaki; Igawa Mikio; Hino Okio
Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis.
Oncogene 2004;23(19):3495-500.
2004: Okimoto Kazuo; Sakurai Junko; Kobayashi Toshiyuki; Mitani Hiroaki; Hirayama Youko; Nickerson Michael L; Warren Michelle B; Zbar Berton; Schmidt Laura S; Hino Okio
A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2023-7.
2004: Kikuchi Yasushi; Sudo Akemi; Mitani Hiroaki; Hino Okio
Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model.
International journal of oncology 2004;24(1):75-80.
2004: Mizuguchi Masashi; Mori Masato; Nozaki Yasuyuki; Momoi Mariko Y; Itoh Masayuki; Takashima Sachio; Hino Okio
Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis.
Acta neuropathologica 2004;107(1):47-52.
2003: Hino Okio
Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype.
Genes, chromosomes & cancer 2003;38(4):357-67.
2003: Testa Joseph R; Hino Okio
Tumor suppressor genes and the two-hit model of recessive oncogenesis: celebrating Alfred Knudson's 80th birthday.
Genes, chromosomes & cancer 2003;38(4):286-7.
2003: Adachi Hiroyuki; Igawa Mikio; Shiina Hiroaki; Urakami Shinji; Shigeno Kazushi; Hino Okio
Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.
The Journal of urology 2003;170(2 Pt 1):601-4.
2003: Honda Satoshi; Kobayashi Toshiyuki; Kajino Kazunori; Urakami Shinji; Igawa Mikio; Hino Okio
Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene.
Molecular carcinogenesis 2003;37(3):122-9.
2003: Ichimiya Harumi; Hino Okio; Kohara Yuji; Ishii Naoaki
VBP-1 is necessary for morphogenesis in Caenorhabditis elegans.
Oncology reports 2003;10(2):293-5.
2003: Hino Okio; Kobayashi Toshiyuki; Momose Shuji; Kikuchi Yasushi; Adachi Hiroyuki; Okimoto Kazuo
Renal carcinogenesis: genotype, phenotype and dramatype.
Cancer science 2003;94(2):142-7.
2003: Okamoto Toshihiro; Kawasaki Toru; Hino Okio
Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.
Biochemical pharmacology 2003;65(4):677-81.
2003: Okamoto Toshihiro; Hara Atsuko; Hino Okio
Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model.
Cancer science 2003;94(1):22-5.
2002: Momose Shuji; Kobayashi Toshiyuki; Mitani Hiroaki; Hirabayashi Masumi; Ito Kazumi; Ueda Masatsugu; Nabeshima Yo-ichi; Hino Okio
Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system.
Human molecular genetics 2002;11(24):2997-3006.
2002: Hayashi Junpei; Kajino Kazunori; Umeda Tomoyuki; Takano Seigo; Arakawa Yasuyuki; Kudo Masatoshi; Hino Okio
Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.
International journal of oncology 2002;21(4):847-50.
2002: Satake Nobuo; Miyagawa Makoto; Sakurai Junko; Mitani Hiroaki; Kobayashi Toshiyuki; Tamura Hiroshi; Hino Okio
N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat.
Cancer letters 2002;184(2):157-63.
2002: Gao Xinsheng; Zhang Yong; Arrazola Peter; Hino Okio; Kobayashi Toshiyuki; Yeung Raymond S; Ru Binggeng; Pan Duojia
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
Nature cell biology 2002;4(9):699-704.
2002: Abe Masanori; Kajino Kazunori; Akbar Sk Md Fazle; Yamamura Ken-Ichi; Onji Morikazu; Hino Okio
Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis.
International journal of molecular medicine 2002;9(1):71-6.
2002: Hino Okio; Kajino Kazunori; Umeda Tomoyuki; Arakawa Yasuo
Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma.
Journal of gastroenterology 2002;37(11):883-7.
2002: Umeda Tomoyuki; Hino Okio
Molecular aspects of human hepatocarcinogenesis mediated by inflammation: from hypercarcinogenic state to normo- or hypocarcinogenic state.
Oncology 2002;62 Suppl 1():38-42.
2002: Sato Teruhiko; Seyama Kuniaki; Fujii Hiroaki; Maruyama Hiroshi; Setoguchi Yasuhiro; Iwakami Shin-ichiro; Fukuchi Yoshinosuke; Hino Okio
Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis.
Journal of human genetics 2002;47(1):20-8.
2001: Hino O; Okimoto K; Kouchi M; Sakurai J
A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10.
Japanese journal of cancer research : Gann 2001;92(11):1147-9.
2001: Hino O
[Hypercarcinogenic state]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 6():45-9.
2001: Wataya-Kaneda M; Kaneda Y; Hino O; Adachi H; Hirayama Y; Seyama K; Satou T; Yoshikawa K
Cells derived from tuberous sclerosis show a prolonged S phase of the cell cycle and increased apoptosis.
Archives of dermatological research 2001;293(9):460-9.
2001: Kobayashi T; Minowa O; Sugitani Y; Takai S; Mitani H; Kobayashi E; Noda T; Hino O
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8762-7.
2001: Hino O; Majima S; Kobayashi T; Honda S; Momose S; Kikuchi Y; Mitani H
Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment.
Mutation research 2001;477(1-2):155-64.
2001: Okamoto T; Momose S; Hino O
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
International journal of oncology 2001;18(1):147-9.
2001: Kajino K; Yamamoto T; Hayashi J; Umeda T; Takahara T; Hino O
Recombination hot spot of hepatitis B virus genome binds to members of the HMG domain protein family and the Y box binding protein family; implication of these proteins in genomic instability.
Intervirology 2001;44(5):311-6.
2001: Akbar S M; Horiike N; Onji M; Hino O
Dendritic cells and chronic hepatitis virus carriers.
Intervirology 2001;44(4):199-208.
2000: Okamoto T; Hino O
Drug development with hints from traditional Indian Ayurveda medicine: hepatitis and rheumatoid as an example.
International journal of molecular medicine 2000;6(6):613-5.
2000: Okimoto K; Kouchi M; Kikawa E; Toyosawa K; Koujitani T; Tanaka K; Matsuoka N; Sakurai J; Hino O
A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.
Japanese journal of cancer research : Gann 2000;91(11):1096-9.
2000: Hayashi J; Aoki H; Kajino K; Moriyama M; Arakawa Y; Hino O
Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.
Hepatology (Baltimore, Md.) 2000;32(5):958-61.
2000: Fukuda T; Tani Y; Kobayashi T; Hirayama Y; Hino O
A new Western blotting method using polymer immunocomplexes: detection of Tsc1 and Tsc2 expression in various cultured cell lines.
Analytical biochemistry 2000;285(2):274-6.
2000: Okamoto T; Hino O
Expression of cyclooxygenase-1 and -2 mRNA in rat tissues: tissue-specific difference in the expression of the basal level of mRNA.
International journal of molecular medicine 2000;6(4):455-7.
2000: Majima S; Kajino K; Fukuda T; Otsuka F; Hino O
A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.
Japanese journal of cancer research : Gann 2000;91(9):869-74.
2000: Fukuda T; Kobayashi T; Momose S; Yasui H; Hino O
Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo.
Laboratory investigation; a journal of technical methods and pathology 2000;80(9):1347-59.
2000: Okamoto T; Yamamura K; Hino O
Expression of the inducible form of the nitric oxide synthase gene in the livers of mice with chronic hepatitis.
International journal of molecular medicine 2000;6(3):315-7.
2000: Okamoto T; Yamamura K; Hino O
Expression of cyclooxygenase mRNA in the livers of mice with interferon-gamma chronic hepatitis.
Japanese journal of pharmacology 2000;83(4):359-61.
2000: Yamashita Y; Yokoyama M; Kobayashi E; Takai S; Hino O
Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model.
Biochemical and biophysical research communications 2000;275(1):134-40.
2000: Umeda T; Yamamoto T; Kajino K; Hino O
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
International journal of oncology 2000;16(6):1133-6.
2000: Mizuguchi M; Takashima S; Yamanouchi H; Nakazato Y; Mitani H; Hino O
Novel cerebral lesions in the Eker rat model of tuberous sclerosis: cortical tuber and anaplastic ganglioglioma.
Journal of neuropathology and experimental neurology 2000;59(3):188-96.
2000: Aoki H; Hayashi J; Moriyama M; Arakawa Y; Hino O
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
Journal of virology 2000;74(4):1736-41.
2000: Yamashita Y; Ono J; Okada S; Wataya-Kaneda M; Yoshikawa K; Nishizawa M; Hirayama Y; Kobayashi E; Seyama K; Hino O
Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations.
American journal of medical genetics 2000;90(2):123-6.
1999: Okamoto T; Kanda T; Yamamura K; Hino O
Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.
International journal of molecular medicine 1999;4(3):261-6.
1999: Fukuda T; Kido A; Kajino K; Tsutsumi M; Miyauchi Y; Tsujiuchi T; Konishi Y; Hino O
Cloning of differentially expressed genes in highly and low metastatic rat osteosarcomas by a modified cDNA-AFLP method.
Biochemical and biophysical research communications 1999;261(1):35-40.
1999: Akbar S M; Kajino K; Tanimoto K; Yamamura K i; Onji M; Hino O
Unique features of dendritic cells in IFN-gamma transgenic mice: relevance to cancer development and therapeutic implications.
Biochemical and biophysical research communications 1999;259(2):294-9.
1999: Yamamoto T; Kajino K; Kudo M; Sasaki Y; Arakawa Y; Hino O
Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA.
Hepatology (Baltimore, Md.) 1999;29(5):1446-52.
1999: Okamoto T; Yamamura K; Hino O
The mouse interferon-gamma transgene chronic hepatitis model (Review).
International journal of molecular medicine 1999;3(5):517-20.
1999: Fukuda T; Kobayashi T; Yasui H; Tsutsumi M; Konishi Y; Hino O
Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry.
Virchows Archiv : an international journal of pathology 1999;434(4):341-50.
1999: Okamoto T; Nakano Y; Yamakawa T; Hara K; Yamamura K I; Hino O
Chronic hepatitis in interferon-gamma transgenic mice is associated with elevated CPP32-like activity and interleukin-1beta-converting enzyme activity suppression.
Japanese journal of pharmacology 1999;79(3):289-94.
1999: Kobayashi T; Minowa O; Kuno J; Mitani H; Hino O; Noda T
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.
Cancer research 1999;59(6):1206-11.
1999: Satake N; Kobayashi T; Kobayashi E; Izumi K; Hino O
Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.
Cancer research 1999;59(4):849-55.
1999: Kajino K; Hino O
TSC1 and TSC2 gene mutations in human kidney tumors.
Contributions to nephrology 1999;128():45-50.
1999: Hayashi J; Aoki H; Arakawa Y; Hino O
Hepatitis C virus and hepatocarcinogenesis.
Intervirology 1999;42(2-3):205-10.
1999: Hino O; Fukuda T; Satake N; Kobayashi T; Honda S; Orimoto K; Yamashita Y; Kikuchi Y
TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1999;35():95-108.
1998: Fukuda T; Hirayama Y; Mitani H; Maeda H; Tsutsumi M; Konishi Y; Hino O
Generation of metastatic variants of Eker renal carcinoma cell lines for experimental investigation of renal cancer metastasis.
Japanese journal of cancer research : Gann 1998;89(11):1104-8.
1998: Fukuda T; Mitani H; Tsutsumi M; Konishi Y; Hino O
Specific induction of hepatocellular adenomas by transplacental administration of ENU in the tsc2 gene mutant (Eker) rat.
International journal of oncology 1998;13(5):957-61.
1998: Okamoto T; Yamakawa T; Yamamura K; Hino O
Induction of Fas ligand and Fas antigen mRNA expressions in interferon-gamma transgenic mouse liver.
Japanese journal of pharmacology 1998;78(2):233-5.
1998: Yamamoto T; Kajino K; Ogawa M; Gotoh I; Matsuoka S; Suzuki K; Moriyama M; Okubo H; Kudo M; Arakawa Y; Hino O
Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration.
Biochemical and biophysical research communications 1998;251(1):339-43.
1998: Satake N; Urakami S; Hirayama Y; Izumi K; Hino O
Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.
International journal of cancer. Journal international du cancer 1998;77(6):895-900.
1998: Orimoto K; Tsuchiya H; Sakurai J; Nishizawa M; Hino O
Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells.
Biochemical and biophysical research communications 1998;247(3):728-33.
1998: Okamoto T; Furuya M; Yamakawa T; Yamamura K; Hino O
Induction of tumor necrosis factor-alpha mRNA in the kidney of the mouse chronic hepatitis model.
Japanese journal of pharmacology 1998;76(1):97-9.
1997: Kajino K; Kamiya N; Yuasa S; Takahara T; Sakurai J; Yamamura K i; Hino O
Evaluation of anti-hepatitis B virus (HBV) drugs using the HBV transgenic mouse: application of the semiquantitative polymerase chain reaction (PCR) for serum HBV DNA to monitor the drug efficacy.
Biochemical and biophysical research communications 1997;241(1):43-8.
1997: Urakami S; Tsuchiya H; Orimoto K; Kobayashi T; Igawa M; Hino O
Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model.
Biochemical and biophysical research communications 1997;241(1):24-30.
1997: Kobayashi T; Urakami S; Cheadle J P; Aspinwall R; Harris P; Sampson J R; Hino O
Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):554-8.
1997: Urakami S; Tokuzen R; Tsuda H; Igawa M; Hino O
Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell.
The Journal of urology 1997;158(1):275-8.
1997: Kobayashi T; Mitani H; Takahashi R; Hirabayashi M; Ueda M; Tamura H; Hino O
Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3990-3.
1997: Kobayashi T; Urakami S; Hirayama Y; Yamamoto T; Nishizawa M; Takahara T; Kubo Y; Hino O
Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model.
Japanese journal of cancer research : Gann 1997;88(3):254-61.
1996: Aoki H; Kajino K; Arakawa Y; Hino O
Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7300-4.
1996: Tsuchiya H; Iseda T; Hino O
Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.
Cancer research 1996;56(13):2881-5.
1996: Orimoto K; Tsuchiya H; Kobayashi T; Matsuda T; Hino O
Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.
Biochemical and biophysical research communications 1996;219(1):70-5.
1996: Tsuchiya H; Orimoto K; Kobayashi K; Hino O
Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model.
Cancer research 1996;56(3):429-33.
1996: Aoki H; Yamamoto T; Kajino K; Arakawa Y; Hino O
Molecular diagnosis of hepatitis C viral infection.
Intervirology 1996;39(3):140-4.
1995: Kajino K; Hino O
[Cellular proteins binding to the hot spot of DNA recombination on the HBV-DNA sequence]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl(Pt 2):94-6.
1995: Kikuchi Y; Kobayashi E; Nishizawa M; Hamazaki S; Okada S; Hino O
Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas.
Japanese journal of cancer research : Gann 1995;86(10):905-9.
1995: Kubo Y; Kikuchi Y; Mitani H; Kobayashi E; Kobayashi T; Hino O
Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.
Japanese journal of cancer research : Gann 1995;86(9):828-32.
1995: Hino O; Kobayashi E; Hirayama Y; Kobayashi T; Kubo Y; Tsuchiya H; Kikuchi Y; Mitani H
Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).
Molecular carcinogenesis 1995;14(1):23-7.
1995: Kobayashi T; Nishizawa M; Hirayama Y; Kobayashi E; Hino O
cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.
Nucleic acids research 1995;23(14):2608-13.
1995: Hino O; Kobayashi T; Mitani H; Kobayashi E; Kubo Y; Tsuchiya H; Kikuchi Y; Nishizawa M; Hirayama Y
The EKER rat, a model of dominantly inherited cancer syndrome.
Transplantation proceedings 1995;27(2):1529-31.
1995: Kubo Y; Klimek F; Kikuchi Y; Bannasch P; Hino O
Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.
Cancer research 1995;55(5):989-90.
1995: Kobayashi T; Kawaguchi T; Kishino T; Matsumoto N; Niikawa N; Mori M; Levan G; Klinga-Levan K; Hino O
Isolation of microdissection clones from rat chromosome 10.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(3):216-8.
1995: Kobayashi T; Hirayama Y; Kobayashi E; Kubo Y; Hino O
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nature genetics 1995;9(1):70-4.
1995: Kajino K; Aoki H; Hino O
Genomic instability involved in virus-related hepatocarcinogenesis.
Intervirology 1995;38(3-4):170-2.
1995: Hino O; Kobayashi E; Nishizawa M; Kubo Y; Kobayashi T; Hirayama Y; Takai S; Kikuchi Y; Tsuchiya H; Orimoto K
Renal carcinogenesis in the Eker rat.
Journal of cancer research and clinical oncology 1995;121(9-10):602-5.
1994: Tsuchiya H; Tsuchiya Y; Kobayashi T; Kikuchi Y; Hino O
Isolation of genes differentially expressed between the Yoshida sarcoma and long-survival Yoshida sarcoma variants: origin of Yoshida sarcoma revisited.
Japanese journal of cancer research : Gann 1994;85(11):1099-104.
1994: Hino O; Kobayashi T; Tsuchiya H; Kikuchi Y; Kobayashi E; Mitani H; Hirayama Y
The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.
Biochemical and biophysical research communications 1994;203(2):1302-8.
1994: Kajino K; Hotta Y; Hino O
Determination of a putative recombinogenic human hepatitis B virus sequence and its binding cellular protein.
Cancer research 1994;54(15):3971-3.
1994: Hino O; Mitani H; Katsuyama H; Kubo Y
A novel cancer predisposition syndrome in the Eker rat model.
Cancer letters 1994;83(1-2):117-21.
1994: Kubo Y; Mitani H; Hino O
Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.
Cancer research 1994;54(10):2633-5.
1994: Hino O; Kajino K
Hepatitis virus-related hepatocarcinogenesis.
Intervirology 1994;37(2):133-5.
1993: Hino O; Mitani H; Knudson A G
Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat.
Cancer research 1993;53(24):5856-8.
1993: Hino O; Mitani H; Nishizawa M; Katsuyama H; Kobayashi E; Hirayama Y
A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat.
Japanese journal of cancer research : Gann 1993;84(11):1106-9.

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