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Toshio Hirano

Research Profile

Chemicals & Drugs

Physiology

Signal Transduction

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TOP 3
Jihye Lee; Shinichiro Miyoshi; Eiichi Morii; Masaaki Murakami; Tomoyuki Nakagiri; Masaya Harada; Toshio Hirano; Masayoshi Inoue; Daisuke Kamimura; Takahiro Oto; Yasushi Shintani; Yoshiyuki Susaki; Meinoshin Okumura
IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation.
Masaaki Murakami; Yuji Nakatsuji; Makoto Nishida; Hideki Ogura; Azusa Okuyama; Yuko Okuyama; Saburo Sakoda; Sayaka Shiraya; Rajeev Singh; Keiko Yamaguchi-Takihara; Jing-Jing Jiang; Daisuke Kamimura; Makoto Kinoshita; Hitoshi Kohsaka; Noriko Kumai; Nobuyuki Miyasaka; Toru Atsumi; Masaya Harada; Toshio Hirano
Disease-association analysis of an inflammation-related feedback loop.
Masaaki Murakami; Yasunobu Arima; Toshio Hirano
[IL-6 signal transduction and its physiological roles].

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All Publications

2013: Jihye Lee; Shinichiro Miyoshi; Eiichi Morii; Masaaki Murakami; Tomoyuki Nakagiri; Masaya Harada; Toshio Hirano; Masayoshi Inoue; Daisuke Kamimura; Takahiro Oto; Yasushi Shintani; Yoshiyuki Susaki; Meinoshin Okumura
IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation.
International immunology 2013;25(5):319-32.
2013: Masaaki Murakami; Yuji Nakatsuji; Makoto Nishida; Hideki Ogura; Azusa Okuyama; Yuko Okuyama; Saburo Sakoda; Sayaka Shiraya; Rajeev Singh; Keiko Yamaguchi-Takihara; Jing-Jing Jiang; Daisuke Kamimura; Makoto Kinoshita; Hitoshi Kohsaka; Noriko Kumai; Nobuyuki Miyasaka; Toru Atsumi; Masaya Harada; Toshio Hirano
Disease-association analysis of an inflammation-related feedback loop.
Cell reports 2013;3(3):946-59.
2012: Masaaki Murakami; Yasunobu Arima; Toshio Hirano
[IL-6 signal transduction and its physiological roles].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():192-206.
2012: Jihye Lee; Shinichiro Miyoshi; Eiichi Morii; Masaya Harada; Toshio Hirano; Masayoshi Inoue; Yoichiro Iwakura; Tomoyuki Nakagiri; Meinoshin Okumura; Takahiro Oto; Yasushi Shintani; Masaaki Murakami
IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1928-36.
2012: Yasunobu Arima; Ulrich A K Betz; Timothy S Blackwell; Masaya Harada; Toshio Hirano; Yoichiro Iwakura; Daisuke Kamimura; Tadafumi Kawamoto; Fuminori Kawano; Gabriel Márquez; Yoshinobu Ohira; Jin-Haeng Park; Fiona E Yull; Masaaki Murakami
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
Cell 2012;148(3):447-57.
2012: Masaaki Murakami; Toshio Hirano
The molecular mechanisms of chronic inflammation development.
Frontiers in immunology 2012;3():323.
2012: Masaaki Murakami; Toshio Hirano
The pathological and physiological roles of IL-6 amplifier activation.
International journal of biological sciences 2012;8(9):1267-80.
2012: Satoru Yamasaki; Toshiyuki Fukada; Aiko Hasegawa; Shintaro Hojyo; Keigo Nishida; Wakana Ohashi; Toshio Hirano
A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave.
PloS one 2012;7(6):e39654.
2011: Bum-Ho Bin; Toshiyuki Fukada; Shintaro Hojyo; Toshiaki Hosaka; Tomohiro Miyai; Keigo Nishida; Wakana Ohashi; Satoru Yamasaki; Shigeyuki Yokoyama; Toshio Hirano
Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome.
The Journal of biological chemistry 2011;286(46):40255-65.
2011: Toshiyuki Fukada; Masaaki Murakami; Keigo Nishida; Satoru Yamasaki; Toshio Hirano
Zinc homeostasis and signaling in health and diseases: Zinc signaling.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(7):1123-34.
2011: Keigo Nishida; Satoru Yamasaki; Aiko Hasegawa; Akihiro Iwamatsu; Haruhiko Koseki; Toshio Hirano
Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):932-41.
2011: Wataru Shioyama; Yoshikazu Nakaoka; Kaori Higuchi; Takashi Minami; Yoshiaki Taniyama; Keigo Nishida; Hiroyasu Kidoya; Takashi Sonobe; Hisamichi Naito; Yoh Arita; Takahiro Hashimoto; Tadashi Kuroda; Yasushi Fujio; Mikiyasu Shirai; Nobuyuki Takakura; Ryuichi Morishita; Keiko Yamauchi-Takihara; Tatsuhiko Kodama; Toshio Hirano; Naoki Mochizuki; Issei Komuro
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.
Circulation research 2011;108(6):664-75.
2011: Masaaki Murakami; Yuko Okuyama; Hideki Ogura; Shogo Asano; Yasunobu Arima; Mineko Tsuruoka; Masaya Harada; Minoru Kanamoto; Yukihisa Sawa; Yoichiro Iwakura; Kiyoshi Takatsu; Daisuke Kamimura; Toshio Hirano
Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells.
The Journal of experimental medicine 2011;208(1):103-14.
2011: Masaaki Murakami; Toshio Hirano
A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases.
Frontiers in immunology 2011;2():22.
2011: Shintaro Hojyo; Toshiyuki Fukada; Shinji Shimoda; Wakana Ohashi; Bum-Ho Bin; Haruhiko Koseki; Toshio Hirano
The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth.
PloS one 2011;6(3):e18059.
2010: Keigo Nishida; Toshio Hirano
[Role of zinc/zinc transporter in allergic response].
Seikagaku. The Journal of Japanese Biochemical Society 2010;82(9):814-24.
2010: Yoshikazu Nakaoka; Wataru Shioyama; Satoshi Kunimoto; Yoh Arita; Kaori Higuchi; Kaori Yamamoto; Yasushi Fujio; Keigo Nishida; Tadashi Kuroda; Hisao Hirota; Keiko Yamauchi-Takihara; Toshio Hirano; Issei Komuro; Naoki Mochizuki
SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
Journal of molecular and cellular cardiology 2010;49(2):157-64.
2010: Chika Kitabayashi; Toshiyuki Fukada; Minoru Kanamoto; Wakana Ohashi; Shintaro Hojyo; Toru Atsumi; Naoko Ueda; Ichiro Azuma; Hiroshi Hirota; Masaaki Murakami; Toshio Hirano
Zinc suppresses Th17 development via inhibition of STAT3 activation.
International immunology 2010;22(5):375-86.
2010: Takayuki Nakagawa; Mineko Tsuruoka; Hideki Ogura; Yuko Okuyama; Yasunobu Arima; Toshio Hirano; Masaaki Murakami
IL-6 positively regulates Foxp3+CD8+ T cells in vivo.
International immunology 2010;22(2):129-39.
2010: Toshio Hirano
Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2010;86(7):717-30.
2009: Keigo Nishida; Aiko Hasegawa; Susumu Nakae; Keisuke Oboki; Hirohisa Saito; Satoru Yamasaki; Toshio Hirano
Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.
The Journal of experimental medicine 2009;206(6):1351-64.
2009: Yukihisa Sawa; Yasunobu Arima; Hideki Ogura; Chika Kitabayashi; Jing-Jing Jiang; Toru Fukushima; Daisuke Kamimura; Toshio Hirano; Masaaki Murakami
Hepatic interleukin-7 expression regulates T cell responses.
Immunity 2009;30(3):447-57.
2009: Toru Atsumi; Masae Sato; Daisuke Kamimura; Arisa Moroi; Yoichiro Iwakura; Ulrich A K Betz; Akihiko Yoshimura; Mika Nishihara; Toshio Hirano; Masaaki Murakami
IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death.
International immunology 2009;21(1):73-80.
2008: Hideki Ogura; Masaaki Murakami; Yuko Okuyama; Mineko Tsuruoka; Chika Kitabayashi; Minoru Kanamoto; Mika Nishihara; Yoichiro Iwakura; Toshio Hirano
Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.
Immunity 2008;29(4):628-36.
2008: Masaaki Murakami; Toshio Hirano
Intracellular zinc homeostasis and zinc signaling.
Cancer science 2008;99(8):1515-22.
2008: Gui-Hua Jin; Toshio Hirano; Masaaki Murakami
Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.
International immunology 2008;20(6):783-9.
2008: Toshiyuki Fukada; Natacha Civic; Tatsuya Furuichi; Shinji Shimoda; Kenji Mishima; Hiroyuki Higashiyama; Yayoi Idaira; Yoshinobu Asada; Hiroshi Kitamura; Satoru Yamasaki; Shintaro Hojyo; Manabu Nakayama; Osamu Ohara; Haruhiko Koseki; Heloisa G Dos Santos; Luisa Bonafe; Russia Ha-Vinh; Andreas Zankl; Sheila Unger; Marius E Kraenzlin; Jacques Beckmann; Ichiro Saito; C Rivolta; Shiro Ikegawa; andrea superti-furga; Toshio Hirano
The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways.
PloS one 2008;3(11):e3642.
2008: Toshio Hirano; Masaaki Murakami; Toshiyuki Fukada; Keigo Nishida; Satoru Yamasaki; Tomoyuki Suzuki
Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule.
Advances in immunology 2008;97():149-76.
2007: Mika Nishihara; Hideki Ogura; Naoko Ueda; Mineko Tsuruoka; Chika Kitabayashi; Fumio Tsuji; Hiroyuki Aono; Katsuhiko Ishihara; Eric Huseby; Ulrich A K Betz; Masaaki Murakami; Toshio Hirano
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.
International immunology 2007;19(6):695-702.
2007: Satoru Yamasaki; Kumiko Sakata-Sogawa; Aiko Hasegawa; Tomoyuki Suzuki; Koki Kabu; Emi Sato; Tomohiro Kurosaki; Susumu Yamashita; Makio Tokunaga; Keigo Nishida; Toshio Hirano
Zinc is a novel intracellular second messenger.
The Journal of cell biology 2007;177(4):637-45.
2007: Khie Khiong; Masaaki Murakami; Chika Kitabayashi; Naoko Ueda; Shin-ichiro Sawa; Akemi Sakamoto; Brian L Kotzin; Stephen Rozzo; Katsuhiko Ishihara; Marileila Verella-Garcia; John Kappler; Philippa Marrack; Toshio Hirano
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model.
The Journal of clinical investigation 2007;117(5):1270-81.
2007: Naofumi Kagara; Natsumi Tanaka; Shinzaburo Noguchi; Toshio Hirano
Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.
Cancer science 2007;98(5):692-7.
2006: Hokuto Kamon; Takaya Kawabe; Hidemitsu Kitamura; Jihye Lee; Daisuke Kamimura; Tsuneyasu Kaisho; Shizuo Akira; Akihiro Iwamatsu; Hisashi Koga; Masaaki Murakami; Toshio Hirano
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.
The EMBO journal 2006;25(17):4108-19.
2006: Naoko Ueda; Hiroko Kuki; Daisuke Kamimura; Shin-ichiro Sawa; Kenichiro Seino; Takuya Tashiro; Ken-ichi Fushuku; Masaru Taniguchi; Toshio Hirano; Masaaki Murakami
CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4.
International immunology 2006;18(9):1397-404.
2006: Hidemitsu Kitamura; Hideyuki Morikawa; Hokuto Kamon; Megumi Iguchi; Shintaro Hojyo; Toshiyuki Fukada; Susumu Yamashita; Tsuneyasu Kaisho; Shizuo Akira; Masaaki Murakami; Toshio Hirano
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
Nature immunology 2006;7(9):971-7.
2006: Koki Kabu; Satoru Yamasaki; Daisuke Kamimura; Yukitaka Ito; Aiko Hasegawa; Emi Sato; Hidemitsu Kitamura; Keigo Nishida; Toshio Hirano
Zinc is required for Fc epsilon RI-mediated mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1296-305.
2006: Daisuke Kamimura; Yukihisa Sawa; Masae Sato; Eviryanti Agung; Toshio Hirano; Masaaki Murakami
IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):306-14.
2006: Shin-ichiro Sawa; Daisuke Kamimura; Gui-Hua Jin; Hideyuki Morikawa; Hokuto Kamon; Mika Nishihara; Katsuhiko Ishihara; Masaaki Murakami; Toshio Hirano
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
The Journal of experimental medicine 2006;203(6):1459-70.
2006: Toshio Hirano; Masaaki Murakami
Grasp a pTyr-peptide by its SOCS.
Developmental cell 2006;10(5):542-4.
2005: Hidemitsu Kitamura; Hokuto Kamon; Shin-ichiro Sawa; Sung-Joo Park; Nobuhiko Katunuma; Katsuhiko Ishihara; Masaaki Murakami; Toshio Hirano
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.
Immunity 2005;23(5):491-502.
2005: Keigo Nishida; Satoru Yamasaki; Yukitaka Ito; Koki Kabu; Kotaro Hattori; Tohru Tezuka; Hirofumi Nishizumi; Daisuke Kitamura; Ryo Goitsuka; Raif S Geha; Tadashi Yamamoto; Takeshi Yagi; Toshio Hirano
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.
The Journal of cell biology 2005;170(1):115-26.
2005: Katsuhiko Ishihara; Toshio Hirano
[gp130F759 mouse].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 1():68-72.
2004: Daisuke Kamimura; Naoko Ueda; Yukihisa Sawa; Shinji Hachida; Toru Atsumi; Takayuki Nakagawa; Shin-ichiro Sawa; Gui-Hua Jin; Haruhiko Suzuki; Katsuhiko Ishihara; Masaaki Murakami; Toshio Hirano
Evidence of a novel IL-2/15R beta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6041-9.
2004: Chiemi Miyagi; Susumu Yamashita; Yusuke Ohba; Hisayoshi Yoshizaki; Michiyuki Matsuda; Toshio Hirano
STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension.
The Journal of cell biology 2004;166(7):975-81.
2004: Sung-Joo Park; Takayuki Nakagawa; Hidemitsu Kitamura; Toru Atsumi; Hokuto Kamon; Shin-ichiro Sawa; Daisuke Kamimura; Naoko Ueda; Yoichiro Iwakura; Katsuhiko Ishihara; Masaaki Murakami; Toshio Hirano
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3844-54.
2004: Tustomu Hirata; Yoko Suda; Kazuki Nakao; Masahiro Narimatsu; Toshio Hirano; Masahiko Hibi
Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;230(3):546-56.
2004: Young-Ki Bae; Takashi Shimizu; Osamu Muraoka; Taijiro Yabe; Tsutomu Hirata; Hideaki Nojima; Toshio Hirano; Masahiko Hibi
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.
Gene expression patterns : GEP 2004;4(4):481-6.
2004: Masaaki Murakami; Daisuke Kamimura; Toshio Hirano
New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27.
Growth factors (Chur, Switzerland) 2004;22(2):75-7.
2004: Susumu Yamashita; Chiemi Miyagi; Toshiyuki Fukada; Naofumi Kagara; Yong-Suk Che; Toshio Hirano
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer.
Nature 2004;429(6989):298-302.
2004: Hideaki Nojima; Takashi Shimizu; Cheol-Hee Kim; Taijiro Yabe; Young-Ki Bae; Osamu Muraoka; Tsutomu Hirata; Ajay B Chitnis; Toshio Hirano; Masahiko Hibi
Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish.
Mechanisms of development 2004;121(4):371-86.
2004: Katsuhiko Ishihara; Shin-ichiro Sawa; Hideto Ikushima; Seiichi Hirota; Toru Atsumi; Daisuke Kamimura; Sung-Joo Park; Masaaki Murakami; Yukihiko Kitamura; Yoichiro Iwakura; Toshio Hirano
The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis.
International immunology 2004;16(3):455-65.
2003: Keigo Nishida; Toshio Hirano
The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors.
Cancer science 2003;94(12):1029-33.
2003: Yoshikazu Nakaoka; Keigo Nishida; Yasushi Fujio; Masahiro Izumi; Kazuo Terai; Yuichi Oshima; Shoko Sugiyama; Satoshi Matsuda; Shigeo Koyasu; Keiko Yamauchi-Takihara; Toshio Hirano; Ichiro Kawase; Hisao Hirota
Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
Circulation research 2003;93(3):221-9.
2003: Taijiro Yabe; Takashi Shimizu; Osamu Muraoka; Young-Ki Bae; Tsutomu Hirata; Hideaki Nojima; Atsushi Kawakami; Toshio Hirano; Masahiko Hibi
Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling.
Development (Cambridge, England) 2003;130(12):2705-16.
2003: Young-Ki Bae; Takashi Shimizu; Taijiro Yabe; Cheol-Hee Kim; Tsutomu Hirata; Hideaki Nojima; Osamu Muraoka; Toshio Hirano; Masahiko Hibi
A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish.
Development (Cambridge, England) 2003;130(9):1853-65.
2003: Satoru Yamasaki; Keigo Nishida; Yuichi Yoshida; Motoyuki Itoh; Masahiko Hibi; Toshio Hirano
Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.
Oncogene 2003;22(10):1546-56.
2003: Daisuke Kamimura; Katsuhiko Ishihara; Toshio Hirano
IL-6 signal transduction and its physiological roles: the signal orchestration model.
Reviews of physiology, biochemistry and pharmacology 2003;149():1-38.
2002: Katsuhiko Ishihara; Toshio Hirano
Molecular basis of the cell specificity of cytokine action.
Biochimica et biophysica acta 2002;1592(3):281-96.
2002: Toru Atsumi; Katsuhiko Ishihara; Daisuke Kamimura; Hideto Ikushima; Takuya Ohtani; Seiichi Hirota; Hideyuki Kobayashi; Sung-Joo Park; Yukihiko Saeki; Yukihiko Kitamura; Toshio Hirano
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.
The Journal of experimental medicine 2002;196(7):979-90.
2002: Takashi Shimizu; Yojiro Yamanaka; Hideaki Nojima; Taijiro Yabe; Masahiko Hibi; Toshio Hirano
A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish.
Mechanisms of development 2002;118(1-2):125-38.
2002: Katsuhiko Ishihara; Toshio Hirano
IL-6 in autoimmune disease and chronic inflammatory proliferative disease.
Cytokine & growth factor reviews 2002;13(4-5):357-68.
2002: Shousaku Itoh; Motoyuki Itoh; Keigo Nishida; Satoru Yamasaki; Yuichi Yoshida; Masahiro Narimatsu; Sung Joo Park; Masahiko Hibi; Katsuhiko Ishihara; Toshio Hirano
Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5110-6.
2002: Daisuke Kamimura; D Fu; Y Matsuda; Toru Atsumi; Takuya Ohtani; Sung Joo Park; Katsuhiko Ishihara; Toshio Hirano
Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility.
Genes and immunity 2002;3(3):136-43.
2002: Susumu Yamashita; Chiemi Miyagi; Amanda Carmany-Rampey; Takashi Shimizu; Ritsuko Fujii; Alexander F Schier; Toshio Hirano
Stat3 Controls Cell Movements during Zebrafish Gastrulation.
Developmental cell 2002;2(3):363-75.
2002: Keigo Nishida; Lin Wang; Eiichi Morii; Sung Joo Park; Masahiro Narimatsu; Shousaku Itoh; Satoru Yamasaki; Masahiro Fujishima; Katsuhiko Ishihara; Masahiko Hibi; Yukihiko Kitamura; Toshio Hirano
Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.
Blood 2002;99(5):1866-9.
2002: Masahiko Hibi; Toshio Hirano; Igor B Dawid
Organizer formation and function.
Results and problems in cell differentiation 2002;40():48-71.
2001: Masahiro Narimatsu; H Maeda; Shinobu Itoh; Toru Atsumi; Takuya Ohtani; Kazuhiko Nishida; Motoyuki Itoh; Daisuke Kamimura; Sung Joo Park; K Mizuno; J i Miyazaki; Masahiko Hibi; Katsuhiko Ishihara; Koichi Nakajima; Toshio Hirano
Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells.
Molecular and cellular biology 2001;21(19):6615-25.
2001: SL Ryu; Ritsuko Fujii; Yojiro Yamanaka; Takashi Shimizu; Taijiro Yabe; Tsutomu Hirata; Masahiko Hibi; Toshio Hirano
Regulation of dharma/bozozok by the Wnt pathway.
Developmental biology 2001;231(2):397-409.
2001: K Mizuno; Takahiro Shirogane; A Shinohara; A Iwamatsu; Masahiko Hibi; Toshio Hirano
Regulation of Pim-1 by Hsp90.
Biochemical and biophysical research communications 2001;281(3):663-9.
2001: Shin-ichi Tsunoda; T Ishikawa; M Watanabe; Haruhiko Kamada; Yoko Yamamoto; Yasuo Tsutsumi; Toshio Hirano; Tadanori Mayumi
Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent.
British journal of haematology 2001;112(1):181-8.
2000: Masahiko Hibi; Takashi Shimizu; Hisashi Hashimoto; SL Ryu; Yojiro Yamanaka; Toshio Hirano
[Axis formation in zebrafish].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(17 Suppl):2720-31.
2000: Osamu Muraoka; H Ichikawa; H Shi; S Okumura; Eiichi Taira; H Higuchi; Toshio Hirano; Masahiko Hibi; Naomasa Miki
Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio).
Developmental biology 2000;228(1):29-40.
2000: Hae-Chul Park; Cheorl-Ho Kim; Young-Ki Bae; Sang-Yeob Yeo; Seok-Hyung Kim; Sung-Kook Hong; Jimann Shin; Kyeong-Won Yoo; Masahiko Hibi; Toshio Hirano; N Miki; Ajay B Chitnis; Tae-Lin Huh
Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
Developmental biology 2000;227(2):279-93.
2000: Hisashi Hashimoto; Taijiro Yabe; Tsutomu Hirata; Takashi Shimizu; Y Bae; Yojiro Yamanaka; Toshio Hirano; Masahiko Hibi
Expression of the zinc finger gene fez-like in zebrafish forebrain.
Mechanisms of development 2000;97(1-2):191-5.
2000: R Fujii; Susumu Yamashita; Masahiko Hibi; Toshio Hirano
Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage.
The Journal of cell biology 2000;150(6):1335-48.
2000: Junko Odajima; Itaru Matsumura; Junko Sonoyama; Hanako Daino; Akira Kawasaki; Hiromitsu Tanaka; Naohiro Inohara; Toshio Kitamura; J Downward; Koichi Nakajima; Toshio Hirano; Yuzuru Kanakura
Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival.
The Journal of biological chemistry 2000;275(31):24096-105.
2000: Tsutomu Hirata; Yojiro Yamanaka; SL Ryu; Takashi Shimizu; Taijiro Yabe; Masahiko Hibi; Toshio Hirano
Novel mix-family homeobox genes in zebrafish and their differential regulation.
Biochemical and biophysical research communications 2000;271(3):603-9.
2000: Toshio Hirano; Katsuhiko Ishihara; Masahiko Hibi
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 2000;19(21):2548-56.
2000: Motoyuki Itoh; Yuichi Yoshida; Kazuhiko Nishida; Masahiro Narimatsu; Masahiko Hibi; Toshio Hirano
Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation.
Molecular and cellular biology 2000;20(10):3695-704.
2000: Hanako Daino; Itaru Matsumura; K Takada; Junko Odajima; Hiromitsu Tanaka; Shuji Ueda; Hirohiko Shibayama; Hirokazu Ikeda; Masahiko Hibi; Takashi Machii; Toshio Hirano; Yuzuru Kanakura
Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells.
Blood 2000;95(8):2577-85.
2000: Masahiko Hibi; Toshio Hirano
Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors.
Leukemia & lymphoma 2000;37(3-4):299-307.
2000: Takashi Shimizu; Yojiro Yamanaka; SL Ryu; Hisashi Hashimoto; Taijiro Yabe; Tsutomu Hirata; Young-Ki Bae; Masahiko Hibi; Toshio Hirano
Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish.
Mechanisms of development 2000;91(1-2):293-303.
2000: Hiromitsu Tanaka; Itaru Matsumura; Koichi Nakajima; Hanako Daino; Junko Sonoyama; Hitoshi Yoshida; Kenji Oritani; Takashi Machii; Masahiro Yamamoto; Toshio Hirano; Yuzuru Kanakura
GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1.
Blood 2000;95(4):1264-73.
2000: Katsuhiko Ishihara; Toshio Hirano
BST-1/CD157 regulates the humoral immune responses in vivo.
Chemical immunology 2000;75():235-55.
2000: Takuya Ohtani; Katsuhiko Ishihara; Toru Atsumi; Kazuhiko Nishida; Y Kaneko; T Miyata; Shinobu Itoh; Masahiro Narimatsu; H Maeda; Toshiyuki Fukada; Motoyuki Itoh; Hideyuki Okano; Masahiko Hibi; Toshio Hirano
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Immunity 2000;12(1):95-105.
2000: Hisashi Hashimoto; M Itoh; Yojiro Yamanaka; Susumu Yamashita; Takashi Shimizu; L Solnica-Krezel; Masahiko Hibi; Toshio Hirano
Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation.
Developmental biology 2000;217(1):138-52.
1999: Takahiro Shirogane; Toshiyuki Fukada; J M Muller; David T Shima; Masahiko Hibi; Toshio Hirano
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.
Immunity 1999;11(6):709-19.
1999: Toshio Hirano
Molecular basis underlying functional pleiotropy of cytokines and growth factors.
Biochemical and biophysical research communications 1999;260(2):303-8.
1999: Shin-ichi Tsunoda; T Ishikawa; Yoko Yamamoto; Haruhiko Kamada; Keiichi Koizumi; J Matsui; Yasuo Tsutsumi; Toshio Hirano; Tadanori Mayumi
Enhanced antitumor potency of polyethylene glycolylated tumor necrosis factor-alpha: a novel polymer-conjugation technique with a reversible amino-protective reagent.
The Journal of pharmacology and experimental therapeutics 1999;290(1):368-72.
1999: Kazuhiko Nishida; Yuichi Yoshida; Motoyuki Itoh; Toshiyuki Fukada; Takuya Ohtani; Takahiro Shirogane; Toru Atsumi; M Takahashi-Tezuka; Katsuhiko Ishihara; Masahiko Hibi; Toshio Hirano
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
Blood 1999;93(6):1809-16.
1999: Kenji Oritani; Yoshiaki Tomiyama; Paul W Kincade; K Aoyama; Takashi Yokota; Itaru Matsumura; Yuzuru Kanakura; Koichi Nakajima; Toshio Hirano; Yuji Matsuzawa
Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells.
Blood 1999;93(4):1346-54.
1999: N Kiuchi; Koichi Nakajima; Makoto Ichiba; Toshiyuki Fukada; Masahiro Narimatsu; K Mizuno; Masahiko Hibi; Toshio Hirano
STAT3 is required for the gp130-mediated full activation of the c-myc gene.
The Journal of experimental medicine 1999;189(1):63-73.
1999: Toshiyuki Fukada; Yuichi Yoshida; Kazuhiko Nishida; Takuya Ohtani; Takahiro Shirogane; Masahiko Hibi; Toshio Hirano
Signaling through Gp130: toward a general scenario of cytokine action.
Growth factors (Chur, Switzerland) 1999;17(2):81-91.
1998: Toshiyuki Fukada; Takuya Ohtani; Yuichi Yoshida; Takahiro Shirogane; Kazuhiko Nishida; Koichi Nakajima; Masahiko Hibi; Toshio Hirano
STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition.
The EMBO journal 1998;17(22):6670-7.
1998: Motoyuki Itoh; Katsuhiko Ishihara; Takachika Hiroi; B O Lee; H Maeda; Hideki Iijima; Masahiko Yanagita; Hiroshi Kiyono; Toshio Hirano
Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3974-83.
1998: K Itoh; K Okubo; H Utiyama; Toshio Hirano; J Yoshii; K Matsubara
Expression profile of active genes in granulocytes.
Blood 1998;92(4):1432-41.
1998: Yojiro Yamanaka; T Mizuno; Y Sasai; M Kishi; Hiroyuki Takeda; Cheorl-Ho Kim; Masahiko Hibi; Toshio Hirano
A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.
Genes & development 1998;12(15):2345-53.
1998: Yuki Shimaoka; JF Attrep; Toshio Hirano; Katsuhiko Ishihara; R Suzuki; T Toyosaki; Takahiro Ochi; Peter E Lipsky
Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells.
The Journal of clinical investigation 1998;102(3):606-18.
1998: M Takahashi-Tezuka; Yuichi Yoshida; Toshiyuki Fukada; Takuya Ohtani; Yojiro Yamanaka; Kazuhiko Nishida; Koichi Nakajima; Masahiko Hibi; Toshio Hirano
Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase.
Molecular and cellular biology 1998;18(7):4109-17.
1998: Makoto Ichiba; Koichi Nakajima; Yojiro Yamanaka; N Kiuchi; Toshio Hirano
Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein.
The Journal of biological chemistry 1998;273(11):6132-8.
1998: Yasufumi Kaneda; Yoko Yamamoto; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi; Toshio Hirano; Tadanori Mayumi
Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice.
Cancer research 1998;58(2):290-5.
1998: Masahiko Hibi; Toshio Hirano
Signal transduction through cytokine receptors.
International reviews of immunology 1998;17(1-4):75-102.
1998: Toshio Hirano
Interleukin 6 and its receptor: ten years later.
International reviews of immunology 1998;16(3-4):249-84.
1997: Cheorl-Ho Kim; Young-Ki Bae; Yojiro Yamanaka; Susumu Yamashita; Takashi Shimizu; Ritsuko Fujii; Hae-Chul Park; Sang-Yeob Yeo; Tae-Lin Huh; Masahiko Hibi; Toshio Hirano
Overexpression of neurogenin induces ectopic expression of HuC in zebrafish.
Neuroscience letters 1997;239(2-3):113-6.
1997: Toshio Hirano; Koichi Nakajima; Masahiko Hibi
Signaling mechanisms through gp130: a model of the cytokine system.
Cytokine & growth factor reviews 1997;8(4):241-52.
1997: Toshihiro Sekimoto; Naoko Imamoto; Koichi Nakajima; Toshio Hirano; Yoshihiro Yoneda
Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1.
The EMBO journal 1997;16(23):7067-77.
1997: Yasufumi Kaneda; Yoko Yamamoto; Shin-ichi Tsunoda; Haruhiko Kamada; Yasuo Tsutsumi; Toshio Hirano; Tadanori Mayumi
Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency.
Biochemical and biophysical research communications 1997;239(1):160-5.
1997: K Shimozaki; Koichi Nakajima; Toshio Hirano; Shigekazu Nagata
Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells.
The Journal of biological chemistry 1997;272(40):25184-9.
1997: Masahiro Narimatsu; Koichi Nakajima; Makoto Ichiba; Toshio Hirano
Association of Stat3-dependent transcriptional activation of p19INK4D with IL-6-induced growth arrest.
Biochemical and biophysical research communications 1997;238(3):764-8.
1997: M Takahashi-Tezuka; Masahiko Hibi; Yoshio Fujitani; Toshiyuki Fukada; T Yamaguchi; Toshio Hirano
Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.
Oncogene 1997;14(19):2273-82.
1997: Yoshio Fujitani; Masahiko Hibi; Toshiyuki Fukada; M Takahashi-Tezuka; Hitoshi Yoshida; T Yamaguchi; K Sugiyama; Yojiro Yamanaka; Koichi Nakajima; Toshio Hirano
An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.
Oncogene 1997;14(7):751-61.
1996: Toshihiro Sekimoto; K Nakajima; T Tachibana; Toshio Hirano; Yoshihiro Yoneda
Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4.
The Journal of biological chemistry 1996;271(49):31017-20.
1996: O Muraoka; H Tanaka; M Itoh; K Ishihara; Toshio Hirano
Genomic structure of human BST-1.
Immunology letters 1996;54(1):1-4.
1996: Y Okuyama; K Ishihara; N Kimura; Y Hirata; K Sato; M Itoh; L B Ok; Toshio Hirano
Human BST-1 expressed on myeloid cells functions as a receptor molecule.
Biochemical and biophysical research communications 1996;228(3):838-45.
1996: Toshiyuki Fukada; Masahiko Hibi; Yojiro Yamanaka; M Takahashi-Tezuka; Yoshio Fujitani; T Yamaguchi; K Nakajima; Toshio Hirano
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.
Immunity 1996;5(5):449-60.
1996: K Ishihara; Y Kobune; Y Okuyama; M Itoh; B O Lee; O Muraoka; Toshio Hirano
Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor.
International immunology 1996;8(9):1395-404.
1996: K Nakajima; Yojiro Yamanaka; K Nakae; H Kojima; Makoto Ichiba; N Kiuchi; T Kitaoka; Toshiyuki Fukada; Masahiko Hibi; Toshio Hirano
A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
The EMBO journal 1996;15(14):3651-8.
1996: B O Lee; K Ishihara; K Denno; Y Kobune; M Itoh; O Muraoka; Tsuneyasu Kaisho; T Sasaki; Takahiro Ochi; Toshio Hirano
Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis.
Arthritis and rheumatism 1996;39(4):629-37.
1996: Yojiro Yamanaka; K Nakajima; Toshiyuki Fukada; Masahiko Hibi; Toshio Hirano
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.
The EMBO journal 1996;15(7):1557-65.
1996: Yoshitaka Kajimoto; Jun-ichiro Miyagawa; K Ishihara; Y Okuyama; Yoshio Fujitani; M Itoh; H Yoshida; Tsuneyasu Kaisho; T Matsuoka; Hirotaka Watada; Toshiaki Hanafusa; Yoshimitsu Yamasaki; T Kamada; Yuji Matsuzawa; Toshio Hirano
Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity.
Biochemical and biophysical research communications 1996;219(3):941-6.
1996: H Kojima; K Nakajima; Toshio Hirano
IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).
Oncogene 1996;12(3):547-54.
1996: Masahiko Hibi; K Nakajima; Toshio Hirano
IL-6 cytokine family and signal transduction: a model of the cytokine system.
Journal of molecular medicine (Berlin, Germany) 1996;74(1):1-12.
1995: K Nakae; K Nakajima; J Inazawa; T Kitaoka; Toshio Hirano
ERM, a PEA3 subfamily of Ets transcription factors, can cooperate with c-Jun.
The Journal of biological chemistry 1995;270(40):23795-800.
1995: K Nakajima; Toshio Matsuda; Yoshio Fujitani; H Kojima; Yojiro Yamanaka; K Nakae; Tsutomu Takeda; Toshio Hirano
Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway.
Annals of the New York Academy of Sciences 1995;762():55-70.
1995: Toshio Matsuda; Toshiyuki Fukada; M Takahashi-Tezuka; Y Okuyama; Yoshio Fujitani; Y Hanazono; H Hirai; Toshio Hirano
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association.
The Journal of biological chemistry 1995;270(19):11037-9.
1995: Toshio Matsuda; M Takahashi-Tezuka; Toshiyuki Fukada; Y Okuyama; Yoshio Fujitani; Satoshi Tsukada; H Mano; H Hirai; O N Witte; Toshio Hirano
Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines.
Blood 1995;85(3):627-33.
1994: Tsutomu Takeda; K Nakajima; H Kojima; Toshio Hirano
E1A repression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4573-82.
1994: M Itoh; K Ishihara; H Tomizawa; H Tanaka; Y Kobune; Jun Ishikawa; Tsuneyasu Kaisho; Toshio Hirano
Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase.
Biochemical and biophysical research communications 1994;203(2):1309-17.
1994: Yoshio Fujitani; K Nakajima; H Kojima; K Nakae; Tsutomu Takeda; Toshio Hirano
Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins.
Biochemical and biophysical research communications 1994;202(2):1181-7.
1994: Toshio Matsuda; Toshio Hirano
Establishment of the ELISA for murine soluble gp130, a signal transducer for the IL-6 family cytokine, and its detection in the ascitic fluids of tumor-bearing mice.
Biochemical and biophysical research communications 1994;202(1):637-42.
1994: Toshio Matsuda; Toshio Hirano
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor.
Blood 1994;83(12):3457-61.
1994: Tsuneyasu Kaisho; Jun Ishikawa; Kenji Oritani; Johji Inazawa; H Tomizawa; O Muraoka; Takahiro Ochi; Toshio Hirano
BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5325-9.
1994: Toshio Hirano; Toshio Matsuda; K Nakajima
Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily.
Stem cells (Dayton, Ohio) 1994;12(3):262-77.
1994: Toshio Matsuda; Yojiro Yamanaka; Toshio Hirano
Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells.
Biochemical and biophysical research communications 1994;200(2):821-8.
1993: O Muraoka; Tsuneyasu Kaisho; M Tanabe; Toshio Hirano
Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site.
Immunology letters 1993;37(2-3):159-65.
1993: K Nakajima; Takeshi Kusafuka; Tsutomu Takeda; Yoshio Fujitani; K Nakae; Toshio Hirano
Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter.
Molecular and cellular biology 1993;13(5):3027-41.
1993: Sachiko Suematsu; T Matsusaka; Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 in myeloma/plasmacytoma.
International review of experimental pathology 1993;34 Pt A():91-8.
1992: Tsuneyasu Kaisho; Kenji Oritani; Jun Ishikawa; M Tanabe; O Muraoka; Takahiro Ochi; Toshio Hirano
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4088-95.
1992: I Kobayashi; Toshio Matsuda; T Saito; K Yasukawa; Hitoshi Kikutani; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.
International immunology 1992;4(12):1407-12.
1992: Kenji Oritani; Tsuneyasu Kaisho; K Nakajima; Toshio Hirano
Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6.
Blood 1992;80(9):2298-305.
1992: Toshio Hirano
Interleukin 6 and autoimmunity and plasma cell neoplasias.
Research in immunology 1992;143(7):759-63.
1992: Toshio Hirano; Tadamitsu Kishimoto
Molecular biology and immunology of interleukin-6.
Research in immunology 1992;143(7):723-4.
1992: Tadatsugu Taniguchi; Nobue Matsuzaki; T Jo; Fumitaka Saji; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto; O Tanizawa
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway.
The Journal of clinical endocrinology and metabolism 1992;74(6):1389-95.
1992: Sachiko Suematsu; T Matsusaka; Toshio Matsuda; S Ohno; J Miyazaki; K Yamamura; Toshio Hirano; Tadamitsu Kishimoto
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):232-5.
1992: Toshio Hirano
Interleukin-6 and its relation to inflammation and disease.
Clinical immunology and immunopathology 1992;62(1 Pt 2):S60-5.
1992: Toshio Hirano
The biology of interleukin-6.
Chemical immunology 1992;51():153-80.
1992: Tetsuya Taga; Masahiko Hibi; M Murakami; M Saito; H Yawata; Michiko Narazaki; Y Hirata; T Sugita; K Yasukawa; Toshio Hirano
Interleukin-6 receptor and signals.
Chemical immunology 1992;51():181-204.
1992: Toshio Hirano; Sachiko Suematsu; T Matsusaka; Toshio Matsuda; Tadamitsu Kishimoto
The role of interleukin 6 in plasmacytomagenesis.
Ciba Foundation symposium 1992;167():188-96; discussion 196-200.
1991: Toshio Hirano
[Cytokines and diseases. Abnormal expression of interleukin 6 and diseases].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1991;80(9):1401-8.
1991: M Fukunaga; Y Fujiwara; M Fujibayashi; S Ochi; K Yokoyama; A Ando; Toshio Hirano; N Ueda; T Kamada
Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells.
FEBS letters 1991;285(2):265-7.
1991: N Sidell; T Taga; Toshio Hirano; Tadamitsu Kishimoto; Andrew Saxon
Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3809-14.
1991: Toshio Hirano
Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias.
International journal of cell cloning 1991;9(3):166-84.
1991: Toshio Matsuda; Toshio Hirano
[Interleukin-6 and its receptor].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(7):1184-94.
1991: K Nakajima; Toshio Hirano
[Basic and clinical aspects of IL-6].
Gan to kagaku ryoho. Cancer & chemotherapy 1991;18(4):505-14.
1991: K Nakajima; Toshio Hirano
[IL-6 receptor and signal transduction pathway].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(4):687-95.
1991: B Tang; Toshio Matsuda; S Akira; N Nagata; S Ikehara; Toshio Hirano; Tadamitsu Kishimoto
Age-associated increase in interleukin 6 in MRL/lpr mice.
International immunology 1991;3(3):273-8.
1990: Masahiko Hibi; M Murakami; M Saito; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Cell 1990;63(6):1149-57.
1990: Toshio Hirano; S Akira; Tetsuya Taga; Tadamitsu Kishimoto
Biological and clinical aspects of interleukin 6.
Immunology today 1990;11(12):443-9.
1990: K Yasukawa; T Saito; T Fukunaga; Y Sekimori; Y Koishihara; H Fukui; Y Ohsugi; Toshio Matsuda; H Yawata; Toshio Hirano
Purification and characterization of soluble human IL-6 receptor expressed in CHO cells.
Journal of biochemistry 1990;108(4):673-6.
1990: Kazuyuki Yoshizaki; Norihiro Nishimoto; K Matsumoto; H Tagoh; Tetsuya Taga; Y Deguchi; T Kuritani; Toshio Hirano; K Hashimoto; N Okada
Interleukin 6 and expression of its receptor on epidermal keratinocytes.
Cytokine 1990;2(5):381-7.
1990: T Sugita; T Totsuka; M Saito; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.
The Journal of experimental medicine 1990;171(6):2001-9.
1990: S Akira; H Isshiki; T Sugita; O Tanabe; Shigeru Kinoshita; Y Nishio; T Nakajima; Toshio Hirano; Tadamitsu Kishimoto
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
The EMBO journal 1990;9(6):1897-906.
1990: H Isshiki; S Akira; O Tanabe; T Nakajima; T Shimamoto; Toshio Hirano; Tadamitsu Kishimoto
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.
Molecular and cellular biology 1990;10(6):2757-64.
1990: Elizabeth Crabb Breen; Ali R Rezai; K Nakajima; G N Beall; Ronald T Mitsuyasu; Toshio Hirano; Tadamitsu Kishimoto; Otoniel Martinez-Maza
Infection with HIV is associated with elevated IL-6 levels and production.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):480-4.
1990: Toshio Hirano; Tetsuya Taga; Toshio Matsuda; Masahiko Hibi; Sachiko Suematsu; B Tang; M Murakami; Tadamitsu Kishimoto
Interleukin 6 and its receptor in the immune response and hematopoiesis.
International journal of cell cloning 1990;8 Suppl 1():155-66; discussion 166-7.
1990: Toshio Matsuda; Toshio Hirano
Interleukin 6 (IL-6).
Biotherapy (Dordrecht, Netherlands) 1990;2(4):363-73.
1990: M Murakami; Toshio Hirano
[IL-6 and IL-6 receptor].
Seikagaku. The Journal of Japanese Biochemical Society 1990;62(1):32-5.
1990: Sachiko Suematsu; Masahiko Hibi; T Sugita; M Saito; M Murakami; T Matsusaka; Toshio Matsuda; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
Current topics in microbiology and immunology 1990;166():13-22.
1989: Y Hirata; Tetsuya Taga; Masahiko Hibi; N Nakano; Toshio Hirano; Tadamitsu Kishimoto
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2900-6.
1989: Sachiko Suematsu; Toshio Matsuda; Katsuyuki Aozasa; S Akira; N Nakano; S Ohno; J Miyazaki; K Yamamura; Toshio Hirano; Tadamitsu Kishimoto
IgG1 plasmacytosis in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7547-51.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; K Yamasaki; K Yasukawa; Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
Cell 1989;58(3):573-81.
1989: Norihiro Nishimoto; Kazuyuki Yoshizaki; H Tagoh; Morito Monden; S Kishimoto; Toshio Hirano; Tadamitsu Kishimoto
Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation.
Clinical immunology and immunopathology 1989;50(3):399-401.
1989: K Nakajima; Otoniel Martínez-Maza; Toshio Hirano; Elizabeth Crabb Breen; P Nishanian; JF Salazar-Gonzalez; John L Fahey; Tadamitsu Kishimoto
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):531-6.
1989: Toshio Matsuda; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Current concepts of B cell modulation.
International reviews of immunology 1989;5(2):97-109.
1989: Toshio Matsuda; Sachiko Suematsu; M Kawano; K Yoshizaki; B Tang; O Tanabe; T Nakajima; S Akira; Toshio Hirano; Tadamitsu Kishimoto
IL-6/BSF2 in normal and abnormal regulation of immune responses.
Annals of the New York Academy of Sciences 1989;557():466-76; discussion 476-7.
1989: Toshio Hirano; Tetsuya Taga; K Yamasaki; Toshio Matsuda; K Yasukawa; Y Hirata; H Yawata; O Tanabe; S Akira; Tadamitsu Kishimoto
Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor.
Annals of the New York Academy of Sciences 1989;557():167-78, discussion 178-80.
1989: Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6: possible implications in human diseases.
La Ricerca in clinica e in laboratorio 1989;19(1):1-10.
1989: Toshio Hirano; Tetsuya Taga; K Yamasaki; Toshio Matsuda; B Tang; Atsushi Muraguchi; Y Horii; Sachiko Suematsu; Y Hirata; H Yawata
A multifunctional cytokine (IL-6/BSF-2) and its receptor.
International archives of allergy and applied immunology 1989;88(1-2):29-33.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; H Yawata; Shunji Natsuka; K Yasukawa; T Totsuka; K Yamasaki; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 receptor and a unique mechanism of its signal transduction.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():713-22.
1989: Toshio Hirano; Tadamitsu Kishimoto
Interleukin 6 and plasma cell neoplasias.
Progress in growth factor research 1989;1(3):133-42.
1989: Toshio Matsuda; Toshio Hirano; S Nagasawa; Tadamitsu Kishimoto
Identification of alpha 2-macroglobulin as a carrier protein for IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):148-52.
1988: O Tanabe; S Akira; T Kamiya; G G Wong; Toshio Hirano; Tadamitsu Kishimoto
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3875-81.
1988: Toshio Hirano; Toshio Matsuda; M Turner; N Miyasaka; G Buchan; B Tang; K Sato; Masahiko Shimizu; Ravinder N Maini; Eugene Eyo Akujuru
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.
European journal of immunology 1988;18(11):1797-801.
1988: Y Horii; Atsushi Muraguchi; Sachiko Suematsu; Toshio Matsuda; K Yoshizaki; Toshio Hirano; Tadamitsu Kishimoto
Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1529-35.
1988: K Yamasaki; Tetsuya Taga; Y Hirata; H Yawata; Y Kawanishi; B Seed; Tadatsugu Taniguchi; Toshio Hirano; Tadamitsu Kishimoto
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
Science (New York, N.Y.) 1988;241(4867):825-8.
1988: Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies.
European journal of immunology 1988;18(6):951-6.
1988: Atsushi Muraguchi; Toshio Hirano; B Tang; Toshio Matsuda; Y Horii; K Nakajima; Tadamitsu Kishimoto
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.
The Journal of experimental medicine 1988;167(2):332-44.
1988: Toshio Hirano; Toshio Matsuda; K Hosoi; A Okano; H Matsui; Tadamitsu Kishimoto
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
Immunology letters 1988;17(1):41-5.
1987: K Yasukawa; Toshio Hirano; Y Watanabe; K Muratani; T Matsuda; S Nakai; Tadamitsu Kishimoto
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
The EMBO journal 1987;6(10):2939-45.
1987: Tetsuya Taga; Y Kawanishi; R R Hardy; Toshio Hirano; Tadamitsu Kishimoto
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.
The Journal of experimental medicine 1987;166(4):967-81.
1986: Hitoshi Kikutani; S Inui; R Sato; E L Barsumian; Hajime Owaki; K Yamasaki; Tsuneyasu Kaisho; N Uchibayashi; R R Hardy; Toshio Hirano
Molecular structure of human lymphocyte receptor for immunoglobulin E.
Cell 1986;47(5):657-65.