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Mutsuko Hirata-Koizumi

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Physiology

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Japan

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Abnormalities, Drug-Induced

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TOP 3
Mariko Matsumoto; Atsushi Ono; Mika Senuma; Mika Takahashi; Hiromasa Takashima; Makiko Yamaguchi; Kazuhito Yokoyama; Yuka Yoshida; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Akihiko Hirose
An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test.
Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Atsushi Ono; Ann Parker; Michael L Dourson; Akihiko Hirose
Safety assessment of boron by application of new uncertainty factors and their subdivision.
Mika Takahashi; Kaoru Yabe; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Akihiko Hirose
Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats.

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All Publications

2013: Mariko Matsumoto; Atsushi Ono; Mika Senuma; Mika Takahashi; Hiromasa Takashima; Makiko Yamaguchi; Kazuhito Yokoyama; Yuka Yoshida; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Akihiko Hirose
An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;56():290-6.
2013: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Atsushi Ono; Ann Parker; Michael L Dourson; Akihiko Hirose
Safety assessment of boron by application of new uncertainty factors and their subdivision.
Regulatory toxicology and pharmacology : RTP 2013;65(1):108-14.
2013: Mika Takahashi; Kaoru Yabe; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Akihiko Hirose
Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats.
Reproductive toxicology (Elmsford, N.Y.) 2013;35():7-16.
2012: Mutsuko Hirata-Koizumi; Sakiko Fujii; Masatoshi Furukawa; Atsushi Ono; Akihiko Hirose
Repeated dose and reproductive/developmental toxicity of perfluorooctadecanoic acid in rats.
The Journal of toxicological sciences 2012;37(1):63-79.
2012: Mutsuko Hirata-Koizumi; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Mika Takahashi; Akihiko Hirose
[Toxicity effects of phthalate substitute plasticizers used in toys].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2012;(130):31-42.
2012: Mariko Matsumoto; Atsushi Ono; Hideki Serizawa; Masao Sunaga; Mika Takahashi; Mutsuko Hirata-Koizumi; Eiichi Kamata; Hina Kato; Akihiko Hirose
No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats.
The Journal of toxicological sciences 2012;37(3):463-74.
2012: Mika Takahashi; Yuko Doi; Akihiro Hagiwara; Mutsuko Hirata-Koizumi; Hina Kato; Reiji Kubota; Tetsuji Nishimura; Atsushi Ono; Akihiko Hirose
Sub-acute oral toxicity study with fullerene C60 in rats.
The Journal of toxicological sciences 2012;37(2):353-61.
2011: Mutsuko Hirata-Koizumi; Sakiko Fujii; Atsushi Ono; Akihiko Hirose; Toshio Imai; Kumiko Ogawa; Makoto Ema; Akiyoshi Nishikawa
Two-generation reproductive toxicity study of aluminium sulfate in rats.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(2):219-30.
2010: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Michael L Dourson; Ann Parker; Lisa M Sweeney; Akiyoshi Nishikawa; Midori Yoshida; Atsushi Ono; Akihiko Hirose
Proposal of new uncertainty factor application to derive tolerable daily intake.
Regulatory toxicology and pharmacology : RTP 2010;58(2):237-42.
2010: Makoto Ema; Ryota Ise; Hirohito Kato; Satoru Oneda; Akihiko Hirose; Mutsuko Hirata-Koizumi; Amar V Singh; Amar Singh; Toshio Ihara
Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide.
Reproductive toxicology (Elmsford, N.Y.) 2010;29(1):49-56.
2009: Mutsuko Hirata-Koizumi; Takashi Matsuyama; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats.
Congenital anomalies 2009;49(4):247-52.
2009: Mika Takahashi; Masao Sunaga; Mutsuko Hirata-Koizumi; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats.
Environmental toxicology 2009;24(1):74-81.
2009: Mutsuko Hirata-Koizumi; Kiyomi Matsuno; Mitsuhiko Kawabata; Kanako Yajima; Takashi Matsuyama; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity.
Drug and chemical toxicology 2009;32(3):204-14.
2009: Makoto Ema; Akihiro Arima; Katsuhiro Fukunishi; Mariko Matsumoto; Mutsuko Hirata-Koizumi; Akihiko Hirose; Toshio Ihara
Developmental toxicity of dibutyltin dichloride given on three consecutive days during organogenesis in cynomolgus monkeys.
Drug and chemical toxicology 2009;32(2):150-7.
2008: Makoto Ema; Sakiko Fujii; Mutsuko Hirata-Koizumi; Mariko Matsumoto
Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats.
Reproductive toxicology (Elmsford, N.Y.) 2008;25(3):335-51.
2008: Mutsuko Hirata-Koizumi; Atsushi Noda; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Reproductive and developmental toxicity screening test of tetrahydrofurfuryl alcohol in rats.
Reproductive toxicology (Elmsford, N.Y.) 2008;25(2):231-8.
2008: Mariko Matsumoto; Mutsuko Hirata-Koizumi; Makoto Ema
Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction.
Regulatory toxicology and pharmacology : RTP 2008;50(1):37-49.
2008: Tomoaki Harada; Eisuke Kimura; Mutsuko Hirata-Koizumi; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Reproductive and developmental toxicity screening study of 4-aminophenol in rats.
Drug and chemical toxicology 2008;31(4):473-86.
2008: Makoto Ema; Katsuhiro Fukunishi; Akihiko Hirose; Mutsuko Hirata-Koizumi; Mariko Matsumoto; Eiichi Kamata
Repeated-dose and reproductive toxicity of the ultraviolet absorber 2-(3',5'-di- tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats.
Drug and chemical toxicology 2008;31(3):399-412.
2008: Mutsuko Hirata-Koizumi; Takashi Matsuyama; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Gender-related difference in the toxicity of ultraviolet absorber 2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats.
Drug and chemical toxicology 2008;31(3):383-98.
2008: Mutsuko Hirata-Koizumi; Takashi Matsuyama; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Lack of gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in preweaning rats.
Drug and chemical toxicology 2008;31(2):275-87.
2008: Mutsuko Hirata-Koizumi; Takashi Matsuyama; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Gonadal influence on the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl) benzotriazole in rats.
Drug and chemical toxicology 2008;31(1):115-26.
2008: Mutsuko Hirata-Koizumi; Hidehiro Ogata; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
A 52-week repeated dose toxicity study of ultraviolet absorber 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats.
Drug and chemical toxicology 2008;31(1):81-96.
2008: Makoto Ema; Sakiko Fujii; Mariko Matsumoto; Mutsuko Hirata-Koizumi; Akihiko Hirose; Eiichi Kamata
Two-generation reproductive toxicity study of the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide in rats.
Reproductive toxicology (Elmsford, N.Y.) 2008;25(1):21-38.
2008: Makoto Ema; Hiroaki Hara; Mariko Matsumoto; Mutsuko Hirata-Koizumi; Akihiko Hirose; Eiichi Kamata
Evaluation of developmental neurotoxicity of polysorbate 80 in rats.
Reproductive toxicology (Elmsford, N.Y.) 2008;25(1):89-99.
2007: Makoto Ema; Sakiko Fujii; Kaoru Yabe; Mariko Matsumoto; Mutsuko Hirata-Koizumi
Evaluation of reproductive and developmental toxicity of the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide in rats.
Congenital anomalies 2007;47(4):149-55.
2007: Mutsuko Hirata-Koizumi; Mitsuo Saito; Shinji Miyake; Ryuichi Hasegawa
Adverse events caused by drug interactions involving glucuronoconjugates of zidovudine, valproic acid and lamotrigine, and analysis of how such potential events are discussed in package inserts of Japan, UK and USA.
Journal of clinical pharmacy and therapeutics 2007;32(2):177-85.
2007: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Michael Dourson; A Parker; Akihiko Hirose; S Nakai; Eiichi Kamata; Makoto Ema
Pediatric susceptibility to 18 industrial chemicals: a comparative analysis of newborn with young animals.
Regulatory toxicology and pharmacology : RTP 2007;47(3):296-307.
2007: Mutsuko Hirata-Koizumi; Nobuaki Watari; Daisuke Mukai; Toshio Imai; Akihiko Hirose; Eiichi Kamata; Makoto Ema
A 28-day repeated dose toxicity study of ultraviolet absorber 2-(2'-hydroxy-3',5'-di-tert-butylphenyl) benzotriazole in rats.
Drug and chemical toxicology 2007;30(4):327-41.
2006: Mika Takahashi; Mutsuko Hirata-Koizumi; Nobuo Nishimura; Yoshihiko Ito; Masao Sunaga; Sakiko Fujii; Eiichi Kamata; Ryuichi Hasegawa; Makoto Ema
Susceptibility of newborn rats to 3-ethylphenol and 4-ethylphenol compared with that of young rats.
Congenital anomalies 2006;46(1):26-33.
2006: Mutsuko Hirata-Koizumi; Mitsuo Saito; Shinji Miyake; Ryuichi Hasegawa
[Study on environmental risk assessment of drugs: excretion forms to environment].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2006;(124):83-6.
2006: Mitsuo Saito; Mutsuko Hirata-Koizumi; Shinji Miyake; Ryuichi Hasegawa
[Investigation on new molecular entities of drugs approved in three regions, Japan, U.S. and EU--common and preceding approvals in current 4 years].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2006;(124):80-2.
2005: Mutsuko Hirata-Koizumi; Masao Hamamura; Hiromi Furukawa; Naemi Fukuda; Yoshihiko Ito; Yumi Wako; Kotaro Yamashita; Mika Takahashi; Eiichi Kamata; Makoto Ema; Ryuichi Hasegawa
Elevated susceptibility of newborn as compared with young rats to 2-tert-butylphenol and 2,4-di-tert-butylphenol toxicity.
Congenital anomalies 2005;45(4):146-53.
2005: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Mika Takahashi; Eiichi Kamata; Makoto Ema
Comparative susceptibility of newborn and young rats to six industrial chemicals.
Congenital anomalies 2005;45(4):137-45.
2005: Mitsuo Saito; Mutsuko Hirata-Koizumi; Shinji Miyake; Ryuichi Hasegawa
Comparison of information on the pharmacokinetic interactions of Ca antagonists in the package inserts from three countries (Japan, USA and UK).
European journal of clinical pharmacology 2005;61(7):531-6.
2005: Mutsuko Hirata-Koizumi; Osamu Kusuoka; Nobuo Nishimura; Hajime Wada; Hidehiro Ogata; Naemi Fukuda; Yoshihiko Ito; Eiichi Kamata; Makoto Ema; Ryuichi Hasegawa
Susceptibility of newborn rats to hepatotoxicity of 1,3-dibromopropane and 1,1,2,2-tetrabromoethane, compared with young rats.
The Journal of toxicological sciences 2005;30(1):29-42.
2005: Mitsuo Saito; Mutsuko Hirata-Koizumi; T Urano; Shinji Miyake; Ryuichi Hasegawa
A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.
Journal of clinical pharmacy and therapeutics 2005;30(1):21-37.
2005: Mika Takahashi; Mutsuko Hirata-Koizumi; Mariko Matsumoto; Akihiko Hirose; Eiichi Kamata; Ryuichi Hasegawa; Makoto Ema
[Progress on OECD chemicals programme (7)--SIAM 15 in Boston, 2002].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2005;(123):46-52.
2005: Mitsuo Saito; Mutsuko Hirata-Koizumi; Shinji Miyake; Ryuichi Hasegawa
[Withdrawal of cerivastatin revealed a flaw of post-marketing surveillance system in the United States].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2005;(123):41-5.
2005: Mutsuko Hirata-Koizumi; Mitsuo Saito; Shinji Miyake; Ryuichi Hasegawa
[Incremental effect and mechanism of cyclosporine on blood concentration of statins and statin package insert information in Japan].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2005;(123):37-40.
2005: Mutsuko Hirata-Koizumi; Mitsuo Saito; Tsutomu Urano; Shinji Miyake; Ryuichi Hasegawa
[Improvement of package insert CYP information for prescription drugs marketed in Japan].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2005;(123):12-8.
2005: Mitsuo Saito; Mutsuko Hirata-Koizumi; Mariko Matsumoto; Tsutomu Urano; Ryuichi Hasegawa
Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies.
Drug safety : an international journal of medical toxicology and drug experience 2005;28(8):677-94.
2004: Mika Takahashi; Hidehiro Ogata; Hiroyuki Izumi; Kotaro Yamashita; Masato Takechi; Mutsuko Hirata-Koizumi; Eiichi Kamata; Ryuichi Hasegawa; Makoto Ema
Comparative toxicity study of 2,4,6-trinitrophenol (picric acid) in newborn and young rats.
Congenital anomalies 2004;44(4):204-14.