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Akihiro Hirata

Research Profile

Procedures

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Chemicals & Drugs

Anatomy

Livers

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Physiology

Cell Proliferation

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Walied Abdo; Ahmed El-Sawak; Akihiro Hirata; Hideki Nikami; Hiroki Sakai; Tokuma Yanai
Combined effects of organochlorine pesticides heptachlor and hexachlorobenzene on the promotion stage of hepatocarcinogenesis in rats.
Toshiya Kuno; Sonoko Masuda; Hideki Mori; Akira Hara; Yuichiro Hatano; Akihiro Hirata; Yoshinobu Hirose; Masaru Terasaki; Hiroyuki Tomita; Takuji Tanaka
Organomagnesium suppresses inflammation-associated colon carcinogenesis in male Crj: CD-1 mice.
Y Kato; K Maruo; T Mori; Mami Murakami; T L D R Nakagawa; Akihiro Hirata; Y Hoshino; Tokuma Yanai; Hiroki Sakai
The Class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma.

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All Publications

2013: Walied Abdo; Ahmed El-Sawak; Akihiro Hirata; Hideki Nikami; Hiroki Sakai; Tokuma Yanai
Combined effects of organochlorine pesticides heptachlor and hexachlorobenzene on the promotion stage of hepatocarcinogenesis in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;55():578-85.
2013: Toshiya Kuno; Sonoko Masuda; Hideki Mori; Akira Hara; Yuichiro Hatano; Akihiro Hirata; Yoshinobu Hirose; Masaru Terasaki; Hiroyuki Tomita; Takuji Tanaka
Organomagnesium suppresses inflammation-associated colon carcinogenesis in male Crj: CD-1 mice.
Carcinogenesis 2013;34(2):361-9.
2013: Y Kato; K Maruo; T Mori; Mami Murakami; T L D R Nakagawa; Akihiro Hirata; Y Hoshino; Tokuma Yanai; Hiroki Sakai
The Class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma.
Journal of comparative pathology 2013;148(2-3):188-96.
2013: Akihiro Hirata; Konrad Hochedlinger; Rudolf Jaenisch; Takahiro Kunisada; Hideyuki Okano; Toshikazu Ushijima; Jochen Utikal; Akira Watanabe; Hitomi Aoki; Nabeel Bardeesy; Akira Hara; Takuya Yamamoto; Satoshi Yamashita; Yasuhiro Yamada
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.
Development (Cambridge, England) 2013;140(1):66-75.
2013: Nguyen Huy Binh; Yuichiro Hatano; Akihiro Hirata; Kazuhiro Kobayashi; Toshiya Kuno; Kunio Satoh; Manabu Takamatsu; Hiroyuki Tomita; Akira Hara
Galectin-3 in preneoplastic lesions of glioma.
Journal of neuro-oncology 2013;111(2):123-32.
2013: Akihiro Hirata; A Kaneko; H Nikami; Hiroki Sakai; K Shigematsu; J Suzuki; Y Tachikawa; K Eguchi; K Hashimoto; Tokuma Yanai
Spontaneous T/NK-cell lymphoma associated with simian lymphocryptovirus in a Japanese macaque (Macaca fuscata).
Journal of comparative pathology 2013;148(1):43-6.
2012: A Murai; Hiroki Sakai; S Abou Asa; Akihiro Hirata; A Kodama; Tokuma Yanai
Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas.
Journal of comparative pathology 2012;147(4):430-40.
2012: A Murai; T Murakami; Hiroki Sakai; S Shiihara; H Ueda; Akihiro Hirata; M Inoue; J Kimura; Tokuma Yanai
Pathological features of Mycobacterium kansasii infection in black bearded sakis (Chiropotes satanas).
Journal of comparative pathology 2012;147(4):566-9.
2012: Y Kato; J Kimura; Mami Murakami; H Notake; Hiroki Sakai; Akihiro Hirata; Tokuma Yanai
Orbital embryonal rhabdomyosarcoma with metastasis in a young dog.
Journal of comparative pathology 2012;147(2-3):191-4.
2012: Atsuko Murai; Samah Abou Asa; Akihiro Hirata; Atsushi Kodama; Tokuma Yanai; Hiroki Sakai
Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.
BMC veterinary research 2012;8():128.
2011: Hiroki Sakai; Masaaki Takeda; Akihiro Hirata; Mami Murakami; Kenta Niimi; Kayoko Yonemaru; Tokuma Yanai
Ganglioneuroma in the urinary bladder of a dog.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2011;73(6):801-3.
2010: Akihiro Hirata; Kayoko Yonemaru; Masahito Kubo; Mami Murakami; Hiroki Sakai; Tokuma Yanai; Toshiaki Masegi
Frequent development of inflammatory lesions and lymphoid foci in the kidneys of Japanese wild crows (Corvus macrorhynchos and Corvus corone) as a result of the entry of causal agents via the renal portal blood.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2010;72(3):327-32.
2010: Suphot Phutthaphadoong; Yasuhiro Yamada; Akihiro Hirata; Hiroyuki Tomita; Akira Hara; Pornngarm Limtrakul; Teruaki Iwasaki; Hiroshi Kobayashi; Hideki Mori
Chemopreventive effect of fermented brown rice and rice bran (FBRA) on the inflammation-related colorectal carcinogenesis in ApcMin/+ mice.
Oncology reports 2010;23(1):53-9.
2010: Yoshiji Asaoka; Hiroki Sakai; Akihiro Hirata; Jun Sasaki; Masanobu Goryo; Yohei Miyamoto; Tokuma Yanai; Toshiaki Masegi; Kosuke Okada
Detection of initiation activity of 1,2-dimethylhydrazine in in vivo medium-term liver initiation assay system using 4-week-old rats without hepatocellular proliferative stimuli during the test chemical treatment period.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2010;72(1):43-53.
2008: Akihiro Hirata; Tetsuya Tsukamoto; Hiroki Sakai; Shinji Takasu; Hisayo Ban; Toshio Imai; Yukari Totsuka; Rena Nishigaki; Keiji Wakabayashi; Tokuma Yanai; Toshiaki Masegi; Masae Tatematsu
Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(6):2003-9.
2008: Takeru Oyama; Yasuhiro Yamada; Kazuya Hata; Hiroyuki Tomita; Akihiro Hirata; Hongqiang Sheng; Akira Hara; Hitomi Aoki; Takahiro Kunisada; Satoshi Yamashita; Hideki Mori
Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.
Carcinogenesis 2008;29(3):666-72.
2007: Akihiro Hirata; Tetsuya Tsukamoto; Masami Yamamoto; Shinji Takasu; Hiroki Sakai; Hisayo Ban; Tokuma Yanai; Toshiaki Masegi; Lawrence A Donehower; Masae Tatematsu
Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine.
Oncology reports 2007;18(4):755-61.
2007: Akihiro Hirata; Tetsuya Tsukamoto; Masami Yamamoto; Shinji Takasu; Hiroki Sakai; Hisayo Ban; Tokuma Yanai; Toshiaki Masegi; Lawrence A Donehower; Masae Tatematsu
Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Cancer science 2007;98(8):1164-73.
2007: Shinji Takasu; Tetsuya Tsukamoto; Akihiro Hirata; Kazuaki Kawai; Takeshi Toyoda; Hisayo Ban; Hiroki Sakai; Tokuma Yanai; Toshiaki Masegi; Hiroshi Kasai; Masae Tatematsu
Lack of initiation activity of 4-oxo-2-hexenal, a peroxidation product generated from omega-3 polyunsaturated fatty acids, in an in vivo five-week liver assay.
Asian Pacific journal of cancer prevention : APJCP 2007;8(3):372-4.
2006: Tetsuya Tsukamoto; Masami Yamamoto; Hiroko Fukami; Akemi Yoshikawa; Hiroki Sakai; Akihiro Hirata; Moriaki Kusakabe; Masae Tatematsu
Susceptibility to colon carcinogenesis in C3H<-->C57BL/6 chimeric mice reflects both tissue microenvironment and genotype.
Cancer letters 2006;239(2):205-11.
2006: Akihiro Hirata; Tetsuya Tsukamoto; Masami Yamamoto; Hiroki Sakai; Tokuma Yanai; Toshiaki Masegi; Lawrence A Donehower; Masae Tatematsu
Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis.
Cancer letters 2006;238(2):271-83.
2006: K Masuno; Tokuma Yanai; Akihiro Hirata; Kayoko Yonemaru; Hiroki Sakai; M Satoh; Toshiaki Masegi; Y Nakai
Morphological and immunohistochemical features of Cryptosporidium andersoni in cattle.
Veterinary pathology 2006;43(2):202-7.
2006: Tetsuya Tsukamoto; Hiroki Sakai; Akihiro Hirata; Hiroko Fukami; Masae Tatematsu
Three-dimensional analysis of isolated hexosaminidase-altered aberrant crypts from colons of 1,2-dimethylhydrazine-treated rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2006;57(4):283-9.
2005: Yoshiji Asaoka; Hiroki Sakai; Naofumi Takahashi; Akihiro Hirata; Tetsuya Tsukamoto; Masami Yamamoto; Tokuma Yanai; Toshiaki Masegi; Masae Tatematsu
Intraperitoneal injection of D-galactosamine provides a potent cell proliferation stimulus for the detection of initiation activities of chemicals in rat liver.
Journal of applied toxicology : JAT 2005;25(6):554-61.
2005: Takeshi Iidaka; Tetsuya Tsukamoto; Yukari Totsuka; Akihiro Hirata; Hiroki Sakai; Norimitsu Shirai; Masami Yamamoto; Keiji Wakabayashi; Tokuma Yanai; Toshiaki Masegi; Lawrence A Donehower; Masae Tatematsu
Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice.
Cancer letters 2005;217(2):149-59.
2004: Kakuya Matsumoto; Tsutomu Mizoshita; Tetsuya Tsukamoto; Naotaka Ogasawara; Akihiro Hirata; Yasuhiro Shimizu; Masakazu Haneda; Kenji Yamao; Masae Tatematsu
Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas.
Oncology reports 2004;12(6):1239-43.
2004: Akihiro Hirata; Ken-ichi Inada; Tetsuya Tsukamoto; Hiroki Sakai; Tsutomu Mizoshita; Tokuma Yanai; Toshiaki Masegi; Hidemasa Goto; Masaki Inagaki; Masae Tatematsu
Characterization of a monoclonal antibody, HTA28, recognizing a histone H3 phosphorylation site as a useful marker of M-phase cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(11):1503-9.
2004: G Ohta; Hiroki Sakai; S Kachi; Akihiro Hirata; Kayoko Yonemaru; A Kitajima; Tokuma Yanai; Toshiaki Masegi
Assessment of proliferative potentials of canine osteosarcomas and chondrosarcomas by MIB-1 immunohistochemistry and bromodeoxyuridine incorporation.
Journal of comparative pathology 2004;131(1):18-27.
2004: Tsutomu Mizoshita; Tetsuya Tsukamoto; Ken-ichi Inada; Naotaka Ogasawara; Akihiro Hirata; Sosuke Kato; Takashi Joh; Makoto Itoh; Yoshitaka Yamamura; Masae Tatematsu
Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa.
Pathology international 2004;54(6):392-400.
2004: M Kobayashi; Hiroki Sakai; Akihiro Hirata; Kayoko Yonemaru; Tokuma Yanai; Kazuhiro Watanabe; Kazuaki Yamazoe; Tadaaki Kudo; Toshiaki Masegi
Expression of myogenic regulating factors, Myogenin and MyoD, in two canine botryoid rhabdomyosarcomas.
Veterinary pathology 2004;41(3):275-7.
2004: Hiroki Sakai; Mika Maruyama; Akihiro Hirata; Kayoko Yonemaru; Tokuma Yanai; Toshiaki Masegi
Rhabdomyosarcoma in a ferret (Mustela putorius furo).
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2004;66(1):95-6.
2003: Hiroki Sakai; Tokuma Yanai; Kayoko Yonemaru; Akihiro Hirata; Toshiaki Masegi
Gallbladder adenocarcinomas in two captive African lions (Panthera leo).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 2003;34(3):302-6.
2003: Hiroki Sakai; Tetsuya Tsukamoto; Masami Yamamoto; Norimitsu Shirai; Takeshi Iidaka; Akihiro Hirata; Tokuma Yanai; Toshiaki Masegi; Lawrence A Donehower; Masae Tatematsu
High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Journal of cancer research and clinical oncology 2003;129(6):335-40.
2003: Tokuma Yanai; N Fujishima; Hideto Fukushi; Akihiro Hirata; Hiroki Sakai; Toshiaki Masegi
Experimental infection of equine herpesvirus 9 in dogs.
Veterinary pathology 2003;40(3):263-7.
2002: Hiroki Sakai; Tetsuya Tsukamoto; Masami Yamamoto; Akihiro Hirata; Atsushi Inagami; Norimitsu Shirai; Takeshi Iidaka; Tokuma Yanai; Toshiaki Masegi; Masae Tatematsu
Summation of initiation activities in the liver after partial hepatectomy.
Cancer letters 2002;176(1):1-5.