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Frank Hirche

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Robert Ringseis; Julia Spielmann; Gabriele I Stangl; Gaiping Wen; Frank Hirche; Janine Keller; Bettina König; Isabel Lukas; Erika Most; Aline Couturier; Klaus Eder
Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.
Romina di Giuseppe; Jutta Dierkes; Frank Hirche; Jukka Montonen; Gabriele I Stangl; Heiner Boeing; Brian Buijsse; Cornelia Weikert
Reliability of plasma fibroblast growth factor 23 as risk biomarker in epidemiological studies measured over a four-month period.
Tobias Gräber; Frank Hirche; Holger Kluge; Jirí Broz; Gabriele I Stangl
Effects of dietary benzoic acid and sodium-benzoate on performance, nitrogen and mineral balance and hippuric acid excretion of piglets.

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All Publications

2013: Robert Ringseis; Julia Spielmann; Gabriele I Stangl; Gaiping Wen; Frank Hirche; Janine Keller; Bettina König; Isabel Lukas; Erika Most; Aline Couturier; Klaus Eder
Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.
Biochimica et biophysica acta 2013;1830(1):2105-17.
2012: Romina di Giuseppe; Jutta Dierkes; Frank Hirche; Jukka Montonen; Gabriele I Stangl; Heiner Boeing; Brian Buijsse; Cornelia Weikert
Reliability of plasma fibroblast growth factor 23 as risk biomarker in epidemiological studies measured over a four-month period.
Annals of clinical biochemistry 2012;49(Pt 6):542-5.
2012: Tobias Gräber; Frank Hirche; Holger Kluge; Jirí Broz; Gabriele I Stangl
Effects of dietary benzoic acid and sodium-benzoate on performance, nitrogen and mineral balance and hippuric acid excretion of piglets.
Archives of animal nutrition 2012;66(3):227-36.
2012: Julika Lietzow; Nicole Seeburg; Corinna Brandsch; Markus Glomb; Frank Hirche; Holger Kluge; Gabriele I Stangl
Effect of short-term UVB exposure on vitamin D concentration of eggs and vitamin D status of laying hens.
Journal of agricultural and food chemistry 2012;60(3):799-804.
2012: M Shibani; Gabriele I Stangl; Frank Hirche; J Keller; H Kluge; B König; Robert Ringseis; K Eder
Effects of fish oil and conjugated linoleic acids on carnitine homeostasis in laying hens.
British poultry science 2012;53(4):431-8.
2012: Nadine Schmidt; Corinna Brandsch; Frank Hirche; Hagen Kühne; Alexandra Thiele; Gabriele I Stangl
Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice.
PloS one 2012;7(4):e35316.
2012: Gloria Schlegel; Frieder J Schwarz; Gabriele I Stangl; Stefanie Geißler; Frank Hirche; Janine Keller; Robert Ringseis; Klaus Eder
Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation.
BMC veterinary research 2012;8():28.
2011: Nicole M Blum; Frank Hirche; Thomas Linn; Doris Lippmann; Erika Most; Kristin Mueller; Josef Pallauf; Andreas S Mueller
Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes.
Food & function 2011;2(11):654-64.
2011: Robert Ringseis; Gabriele I Stangl; Gaiping Wen; Frank-Christoph Mooren; Aline Couturier; Klaus Eder; Frank Hirche; Janine Keller; Karsten Krüger
Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.
Molecular nutrition & food research 2011;55 Suppl 2():S193-202.
2010: Nicole M Wolf; Kristin Mueller; Frank Hirche; Erika Most; Josef Pallauf; Andreas S Mueller
Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations.
The British journal of nutrition 2010;104(4):520-32.
2010: Kristin Weisse; Corinna Brandsch; Frank Hirche; Klaus Eder; Gabriele I Stangl
Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice.
The British journal of nutrition 2010;103(2):180-8.
2009: Robert Ringseis; Nicole Wege; Gaiping Wen; Christine Rauer; Frank Hirche; Holger Kluge; Klaus Eder
Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species.
The Journal of nutritional biochemistry 2009;20(11):840-7.
2009: Frank Hirche; Maren Fischer; Janine Keller; Klaus Eder
Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(22):2158-62.
2009: Maren Fischer; Janine Keller; Frank Hirche; Holger Kluge; Robert Ringseis; Klaus Eder
Activities of gamma-butyrobetaine dioxygenase and concentrations of carnitine in tissues of pigs.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2009;153(3):324-31.
2009: Bettina König; Alexander Koch; Julia Spielmann; Christian Hilgenfeld; Frank Hirche; Gabriele I Stangl; Klaus Eder
Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
European journal of pharmacology 2009;605(1-3):23-30.
2009: Maren Fischer; Juliane Varady; Frank Hirche; Holger Kluge; Klaus Eder
Supplementation of L-carnitine in pigs: absorption of carnitine and effect on plasma and tissue carnitine concentrations.
Archives of animal nutrition 2009;63(1):1-15.
2009: Anke Gutgesell; Robert Ringseis; Corinna Brandsch; Gabriele I Stangl; Frank Hirche; Klaus Eder
Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats.
Metabolism: clinical and experimental 2009;58(2):226-32.
2008: Robert Ringseis; Silvia Lüdi; Frank Hirche; Klaus Eder
Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;58(1):58-64.
2008: Anja Bettzieche; Corinna Brandsch; Kristin Weisse; Frank Hirche; Klaus Eder; Gabriele I Stangl
Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats.
The British journal of nutrition 2008;99(5):952-62.
2008: Robert Ringseis; Sebastian Luci; Julia Spielmann; Holger Kluge; Maren Fischer; Stefanie Geissler; Gaiping Wen; Frank Hirche; Klaus Eder
Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species.
European journal of pharmacology 2008;583(1):11-7.
2008: Anja Bettzieche; Corinna Brandsch; Frank Hirche; Klaus Eder; Gabriele I Stangl
L-cysteine down-regulates SREBP-1c-regulated lipogenic enzymes expression via glutathione in HepG2 cells.
Annals of nutrition & metabolism 2008;52(3):196-203.
2008: Sebastian Luci; Frank Hirche; Klaus Eder
Fasting and caloric restriction increases mRNA concentrations of novel organic cation transporter-2 and carnitine concentrations in rat tissues.
Annals of nutrition & metabolism 2008;52(1):58-67.
2007: Jane Doberenz; Frank Hirche; Uta Keller; Klaus Eder
Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status.
Reproductive toxicology (Elmsford, N.Y.) 2007;24(1):83-8.
2007: Anjali Shukla; Corinna Brandsch; Anja Bettzieche; Frank Hirche; Gabriele I Stangl; Klaus Eder
Isoflavone-poor soy protein alters the lipid metabolism of rats by SREBP-mediated down-regulation of hepatic genes.
The Journal of nutritional biochemistry 2007;18(5):313-21.
2007: Julia Spielmann; Anjali Shukla; Corinna Brandsch; Frank Hirche; Gabriele I Stangl; Klaus Eder
Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c.
Annals of nutrition & metabolism 2007;51(4):387-92.
2007: Gabriele I Stangl; Kristin Weisse; Cornelia Dinger; Frank Hirche; Corinna Brandsch; Klaus Eder
Homocysteine thiolactone-induced hyperhomocysteinemia does not alter concentrations of cholesterol and SREBP-2 target gene mRNAS in rats.
Experimental biology and medicine (Maywood, N.J.) 2007;232(1):81-7.
2006: Sebastian Luci; Stefanie Geissler; Bettina König; Alexander Koch; Gabriele I Stangl; Frank Hirche; Klaus Eder
PPARalpha agonists up-regulate organic cation transporters in rat liver cells.
Biochemical and biophysical research communications 2006;350(3):704-8.
2006: Corinna Brandsch; Anjali Shukla; Frank Hirche; Gabriele I Stangl; Klaus Eder
Effect of proteins from beef, pork, and turkey meat on plasma and liver lipids of rats compared with casein and soy protein.
Nutrition (Burbank, Los Angeles County, Calif.) 2006;22(11-12):1162-70.
2006: Sebastian Luci; Holger Kluge; Frank Hirche; Klaus Eder
Clofibrate increases hepatic triiodothyronine (T3)- and thyroxine (T4)-glucuronosyltransferase activities and lowers plasma T3 and T4 concentrations in pigs.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(11):1887-92.
2006: Anjali Shukla; Anja Bettzieche; Frank Hirche; Corinna Brandsch; Gabriele I Stangl; Klaus Eder
Dietary fish protein alters blood lipid concentrations and hepatic genes involved in cholesterol homeostasis in the rat model.
The British journal of nutrition 2006;96(4):674-82.
2006: Anett Klopotek; Frank Hirche; Klaus Eder
PPAR gamma ligand troglitazone lowers cholesterol synthesis in HepG2 and Caco-2 cells via a reduced concentration of nuclear SREBP-2.
Experimental biology and medicine (Maywood, N.J.) 2006;231(8):1365-72.
2006: Frank Hirche; A Schröder; B Knoth; Gabriele I Stangl; Klaus Eder
Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism.
The British journal of nutrition 2006;95(5):879-88.
2006: Frank Hirche; Arlette Schroder; Berit Knoth; Gabriele I Stangl; Klaus Eder
Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats.
Annals of nutrition & metabolism 2006;50(2):139-46.
2005: Andrew A Fatufe; Frank Hirche; Markus Rodehutscord
Estimates of individual factors of the tryptophan requirement based on protein and tryptophan accretion responses to increasing tryptophan supply in broiler chickens 8-21 days of age.
Archives of animal nutrition 2005;59(3):181-90.
2005: K Eder; Frank Hirche; H Kluge; G Müller; Corinna Brandsch
Concentrations of oxysterols in meat and meat products from pigs fed diets differing in the type of fat (palm oil or soybean oil) and vitamin E concentrations.
Meat science 2005;70(1):15-23.
2005: Klaus Eder; Gerit Grünthal; Holger Kluge; Frank Hirche; Joachim Spilke; Corinna Brandsch
Concentrations of cholesterol oxidation products in raw, heat-processed and frozen-stored meat of broiler chickens fed diets differing in the type of fat and vitamin E concentrations.
The British journal of nutrition 2005;93(5):633-43.
2004: Andrea Sülzle; Frank Hirche; Klaus Eder
Thermally oxidized dietary fat upregulates the expression of target genes of PPAR alpha in rat liver.
The Journal of nutrition 2004;134(6):1375-83.
2003: Klaus Eder; Uta Keller; Frank Hirche; Corinna Brandsch
Thermally oxidized dietary fats increase the susceptibility of rat LDL to lipid peroxidation but not their uptake by macrophages.
The Journal of nutrition 2003;133(9):2830-7.
2003: Diana Flader; Corinna Brandsch; Frank Hirche; Klaus Eder
Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2003;73(4):275-83.
2003: S Peganova; Frank Hirche; Klaus Eder
Requirement of tryptophan in relation to the supply of large neutral amino acids in laying hens.
Poultry science 2003;82(5):815-22.
2003: Peter Skufca; Corinna Brandsch; Frank Hirche; Klaus Eder
Effects of a dietary thermally oxidized fat on thyroid morphology and mRNA concentrations of thyroidal iodide transporter and thyroid peroxidase in rats.
Annals of nutrition & metabolism 2003;47(5):207-13.
2003: Klaus Eder; Andrea Suelzle; Peter Skufca; Corinna Brandsch; Frank Hirche
Effects of dietary thermoxidized fats on expression and activities of hepatic lipogenic enzymes in rats.
Lipids 2003;38(1):31-8.
2002: Klaus Eder; Diana Flader; Frank Hirche; Corinna Brandsch
Excess dietary vitamin E lowers the activities of antioxidative enzymes in erythrocytes of rats fed salmon oil.
The Journal of nutrition 2002;132(11):3400-4.